LOCUS       NZ_CP104794            10216 bp    DNA     linear   CON 09-JUL-2024
DEFINITION  Streptomyces sp. FZ201 chromosome, complete genome.
ACCESSION   NZ_CP104794
VERSION     NZ_CP104794.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. FZ201
  ORGANISM  Streptomyces sp. FZ201
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8604396)
  AUTHORS   Zhang,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2022) College of Life Science and Technology,
            Jinan University, Guangzhou, Guangzhou, Guangdong 510632, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAY-2021
            Assembly Method                   :: unicycler v. 3.14.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.1x
            Sequencing Technology             :: Illumina NovaSeq6000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025402955.1-RS_2024_07_09
            Annotation Date                   :: 07/09/2024 06:54:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,471
            Genes (coding)                    :: 7,336
            CDSs (with protein)               :: 7,336
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 135
            CDSs (without protein)            :: 135
            Pseudo Genes (ambiguous residues) :: 0 of 135
            Pseudo Genes (frameshifted)       :: 55 of 135
            Pseudo Genes (incomplete)         :: 92 of 135
            Pseudo Genes (internal stop)      :: 7 of 135
            Pseudo Genes (multiple problems)  :: 18 of 135
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:45:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7989826
            Orig. end                         :: 8000042
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP104794.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zhang Fei, College of Life
            Science and Technology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="30"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1879..4101)
                     /locus_tag="N6J21_RS35145"
     CDS             complement(1879..4101)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="N6J21_RS35145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_261720250.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.9e-38, bitscore:
                     129.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVQETRHRRRAAPPKRPVPQGRSRTVRTPTVLQMEAVECGAAC
                     LAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDTAALAGVTA
                     PAVLFWEFNHYVVYDGMGRRFGRRGVYINDPAKGRRFVPMEDFDGSFTGVVLVMEPGEG
                     FRKGGRKPGVLGALPARMRGTAGTLPAAVLASLLLVAVGATVPALSRTYIDTFLIGGQT
                     SLLGVLFASMGASVLLTLVLTWLQQANLLRGRIISSTLSSARFLRHLLRLPVTFFSHRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAVVVVLYAVLLYTYDPQLTAVGIGVALLNIV
                     AMRVVVRLRATRTAKLRADSARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSALILWIGGMRAVEGHITVGLLVAFQALVTRFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFRTDPLYARPGGAESTRRLHGHVELENITFGYNP
                     LDKPLLTGFDLTVGPGRQVALVGGSGSGKSTVSRIISGLYTPWEGVIRIDGQRLEDIPR
                     GALAASVSFVDQEVFLFEGTVRDNVALWDPSVPDEAVIEALRDAALYDVVARRPGGIHS
                     RVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETELVVMDNLRRRGCACV
                     VIAHRLSTVRDSDEIVVLEHGTIVERGRHEELVACGGAYAALVRER"
     gene            complement(4098..4904)
                     /locus_tag="N6J21_RS35150"
     CDS             complement(4098..4904)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="N6J21_RS35150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_261720251.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLTLAVTVVVMAAAAVW
                     AVTGSVTSTVGAPAVLTHGQGSYILQSPVAGQVTAVLAKQGERLPANSPVLKVRTAEGE
                     TVVRTVAAGRVTALAATIGQIISTGANVAAVEKVADPEDPLYATVYVPAQNAASIPEGA
                     AVDLTVQSVPAQEYGVLRGHVKSVDRGAQSAQSITSFLGDSQLGEQFTEDGRPVAVLVT
                     LDKSAATKSGYAWSSADGPPFSLTSMTLAEASVRLADERPVDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="N6J21_RS35155"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="N6J21_RS35155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type A2 lantipeptide"
                     /protein_id="WP_093723990.1"
                     /sec_met_domain="strepbact (E-value: 1.1e-36, bitscore:
                     123.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETVEISDAELDNVSGGLSVNALGTVTGLVDGIAPVSGL
                     VDTAVGTVEGVTGLNTAPVTSLVAGL"
     misc_feature    complement(5391..5404)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    5460..5475
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.45"
                     /tool="antismash"
     misc_feature    5674..5692
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.38"
                     /tool="antismash"
     gene            complement(5685..6098)
                     /locus_tag="N6J21_RS35160"
     CDS             complement(5685..6098)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676669.1"
                     /locus_tag="N6J21_RS35160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PaaI family thioesterase"
                     /protein_id="WP_093723989.1"
                     /transl_table=11
                     /translation="MTMTTAEADKILADNFAPWVLELGLTVEGLDDHRAVLRLPWSQRL
                     AREGGALSGQALMAAADTATVLAVSAARGAYGPMTTVQQSTSFQRAVTGSDVLIEAVIT
                     KLGRRMAFADITMTDATTGQIAARASTVYALLG"
     misc_feature    complement(6141..6155)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    6178..6189
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            6287..7642
                     /locus_tag="N6J21_RS35165"
     CDS             6287..7642
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978109.1"
                     /locus_tag="N6J21_RS35165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S1 family peptidase"
                     /protein_id="WP_261720252.1"
                     /transl_table=11
                     /translation="MSHKRMPKRKAAIAAGGVAALGAAAILLPQANASQDGASDEAAAP
                     RTLKAADASDLASQLAGLLGDAFAGSYYDADNQQLVVNVVPGDNNNVIVQAKKAGAKVR
                     EVDNSLAELDAGAKTLKAKATIPGTSWAVDPRTNKILVTADSTVTGDKWDQLESTVESL
                     GSGMATIKKSQGTFKTFLSGGDAIFAGGARCSAGFNVTAGDGSPAFLTAGHCGVAAAQW
                     SDSQGGAPVATVDAETATFPGTGDFALVKYDDPATQAPSEVNLGNQTVAISQAAEATVG
                     LQVFRMGSTTGLSDGQVLGLNATVNYPEGTVTGLIQTNVCAEPGDSGGSLFTQDGLAIG
                     LTSGGSGDCTVGGETFFQPVTTALEATGATLGAGGAAGDGGAGQDAGAGDEAGAGQDAG
                     AGQDAGAGQDAGAGQDAGAGQEAGAGDDAGAGEDAGLGEEVDMGEQAGRRSH"
     gene            complement(7783..9930)
                     /locus_tag="N6J21_RS35170"
     CDS             complement(7783..9930)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="N6J21_RS35170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_261720696.1"
                     /transl_table=11
                     /translation="MVGVSDGQDSAQAPATTRTRVGRPLLSLALASMMDEVHAHSGAVY
                     LRAADEPVLEMAVMAGLPRAFAAPWERVGLGAPVPVADAARERRLVWVSGEEEMARLYP
                     RISVVLPYPFALAALPVATDSTVYGAVFVTWPGSHPPDLSERERTHLAAACDRLATRLA
                     RALEDSVPLLPEPDLLAAPSLAGAAGTLGTVESARMVARLPYGLCSLDLHGRICFANAA
                     AAELIGIPVSQLLGTQLWASVPWLNDPVYEDRYRAALFSQQTTSFVALRPPADWLSFRL
                     YPSTTGLSVRVTRARAVAEMNRRHRPPADAPTRLVTISQLLSLASSLTEAVGVQDVVQL
                     VADEIAPAVGSQALVVLGSRAGRLHVLGHHGYPDASFVEQFDGLPMTERTPGTHALTTG
                     VPAFFEDRQQLERLYPVREATPDGFAAWAYLPLIASGRPVGTVVLAYTEPHTFPADERS
                     VLTSMGGLIAQALERAMLYDAKHHLAHGLQAALLPHSLPPLPGIEAAARYLPATQGMDI
                     GGDFYDLVPVQGQAAAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQPPEEVMRSTNRL
                     LIDLGAELFASCLYLRLDPERGRAVMARAGHPPPLLRRPDGKVRVLDLAGGPLLGIDGS
                     AGYQTTEVDLAPGSVLALYTDGLIESPGIDIEDALAELGNLLTTAGDAPLDALADHLVE
                     SAALPRGRADDVAVLLLRAED"
     misc_feature    complement(9959..9973)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.29"
                     /tool="antismash"
     misc_feature    complement(10186..10200)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
ORIGIN
        1 agggtgcaca acggcagata gaccgcaccc agcaccgcgc cgaggttctt gatccggccc
       61 accttctgct gcagctcccg gctgcgcgcg aactgcgcgg cccaggcggc gtacgcgtag
      121 ttctccgccg ccgccacgcg cagcttgggc agtccgcgca gggtctggaa ggcctggttg
      181 ttcagcttgt tgctcagcac cacgagccgc cgctgccagc gcacctgcca catcccgagc
      241 cccaggaaca ccgcggcgac cacgaccagc acaccgatcg ccacgagcgc catcggcacg
      301 ctgaaccaca gcagcaggcc caggttcatc gcgccgaccg tcaccgactg ggcgaccgtg
      361 gggccgaccc cggccagcag tctgcggatc gcgctgatgc ccatggccgc gctcgccagt
      421 tcgcccgtgg aacgctcggt gaagaacttc gtcggcagcc gcagcagccg gtcccagacg
      481 gcgggctgga gggtggcctc gatccggccc tccaggcgca ggacggtcag gttctgcaac
      541 agcaggaacg ccgccgccac caccccgccg accatcaccg ccagacacac ctgcgcgatc
      601 aggtccgtct gtgccgtcgg cacgaactcg ccgagcacct tgcccgtcgc gagcggcacc
      661 agggccccga ccgccaccgt taccagaccg ctgagcagca ggttcagcag atcgcgtgag
      721 gtgccgcgca gggtgaaccg gagcaggccg agcgggctcg gtgcccggtc gggaagcggc
      781 cggtagaaca tcaccgcacg cggctcgaac tcctccgcgt tggccttctc caccggcgtc
      841 tcccggccgg tcgccggatg gacggcgaca tagccgccgc gccgccacag cagggcgacc
      901 ggtgcccccg atagggcacg ccggcccacc agcgggccga tgtcgtcgcg ccaccagcgg
      961 ccctccagcc gtaccgcgcg ggtgcgcacg cgggaggcga gggccacccg ctccaccggg
     1021 tcgagccggt cgctctcggt accggtgcgc gcggggtcgg ccagggtgat cccggcggcc
     1081 cgggcgacga gttcgcaggc ggcgtaggtg gcgtccgcgt cggcggccgt cgtgcgcggg
     1141 cccgaccgct tgccgatgga cgccagcagg gtccggtcgg cctgggcgcg caccgcctca
     1201 ccggccctga tgccctccgc ggtgcgggtc tcgtgggtgc gctccagctg ctcgatccag
     1261 cggtcgagcg tggtcagcag gcggtactgc tggtccacca tgctctgcca cagcgccggg
     1321 tcgatcagca ggtcggcggc ggcctcctgg ccgtacagcg agccgtactg gacactgccg
     1381 ggcggcacct gcatccagaa cacgtcgtcg tcggtgacct gcgcggcccg ctcaccggcc
     1441 atcggcgcct ggaacaggat cgacagactg cggcccacac cgagggcgag ggcgtactcc
     1501 agcggtccgg gctgcggcgg gacgtactgc gggttgccgt aggcgtcgta ggaccaggtc
     1561 tcggtgggtg cgggccggta cagctcgcgc agggcgacgc ggtgcaccac acagtccctg
     1621 agcgggcgcg cgaccagggt gtgccgcgct cccgcggccg ggccgagcag cagcgagccc
     1681 gcctccagac ggcccaggtg gtgccagtgg ccccgctgtt cggcgtccac cgcgaacagg
     1741 tccaccgcgc cggacgccac cagccacagc acctgcgggc cttcgaggtc caggcggttg
     1801 aacccggcgc agtcgatccg gccgcccagc gcgccgagcg cgttcaggac caggtcgccc
     1861 tcgtgcacgg acgtcatctc accgctccct gaccagcgcc gcgtacgcgc cgccgcacgc
     1921 gacgagttcc tcgtgccggc cgcgctccac gatcgtgccg tgctccagta cgacgatctc
     1981 gtcgctgtcg cgcaccgtgc tcagccggtg cgcgatgacc acacaggcac agccccgcct
     2041 gcgcaggttg tccatgacga ccagctcggt ctccgcgtcc agcgcgctgg tcacctcgtc
     2101 cagcaccagg atgctcggcc gccgcaccaa cgcccgggcg atctccagac gttggcgctg
     2161 gccgccggag aagttccggc cgtcctgctc cacccggctg tggatgccac cgggccgccg
     2221 cgcgaccacg tcgtacaggg ccgcgtcccg cagcgcctcg atcaccgcct cgtccgggac
     2281 ggacgggtcc cacagcgcca cgttgtcccg gaccgtgccc tcgaacagga acacctcctg
     2341 gtccacgaag gagacggacg ccgcgagcgc gccgcgcgga atgtcctcca gccgctgccc
     2401 gtcgatgcgg atcacgccct cccagggcgt gtacaggccc gagatgatcc gggacaccgt
     2461 ggacttgccg ctgcccgaac cgccgaccag ggcgacctgg cggcccggac ccacggtcag
     2521 gtcgaagccg gtcagcaggg gcttgtccag cgggttgtag ccgaaggtga tgttctccag
     2581 ctccacatgc ccgtgcagac ggcgggtgga ctcggcgccg cccgggcggg cgtacagcgg
     2641 gtccgtgcgg aagttctcca cgtccttcag ccgggccacg tccgccgcga agtcctggat
     2701 gcggcccgcc acgccgttga gccgggtcag cggggcggtg aaacgggtga ccagcgcctg
     2761 gaaggcgacc agcagaccga ccgtgatgtg cccctcgacc gcgcgcatcc cgccgatcca
     2821 caggatcagc gcgctgttca gggtggcgag cgtcggcgcg accacgccca gccaggcgct
     2881 cggcaccccg aggcgctgct gctcctccag ggtggtggcg tgctgtccgg cccacttgcg
     2941 gaagtagccg tcctcgccgc cggtcgcctt catcgtctcg atcaactgaa gcccggtgta
     3001 ggcggtgttg gtgagccggg cactgtccgc gcgcagcttg gcggtgcggg tggcgcgcag
     3061 ccgtacgacg acacgcatcg ccacgatgtt cagcagcgcg acgccgatgc ctacggcggt
     3121 cagctgcggg tcgtaggtgt agagcaggac cgcgtacagg accacgacca ccgcgtccac
     3181 gcccgccgcg gcaaggtcgc gggccagggt ctccgccacg gcgtcgttgg actgcaggcg
     3241 ctgcaccagg tcggccgggc tgcggtggga gaagaaggtg accggcagcc gcagcagatg
     3301 gcgcaggaag cgggcgctgg agagcgtgga ggagatgatc cgcccgcgca gcaggttcgc
     3361 ctgctggagc caggtcagta cgagggtgag cagcacggag gcgcccatgg acgcgaacag
     3421 cacgcccagc agggaggtct gaccgccgat caggaaggtg tcgatgtagg tgcggctcag
     3481 ggcgggcacg gtcgcgccga ccgcgaccag cagcaggctg gccagcacgg cggcgggcag
     3541 ggtgcccgcg gtgccgcgca tccgggcggg cagcgcgccg agcacccccg gcttgcggcc
     3601 gcccttgcgg aagccctcgc cgggctccat caccaggacg acaccggtga agctgccgtc
     3661 gaagtcctcc atcgggacga aacggcggcc cttggccggg tcgttgatgt agaccccgcg
     3721 gcggccgaag cggcgcccca tgccgtcgta gacgacgtag tggttgaact cccagaacag
     3781 caccgccggt gccgtcaccc cggcgagggc ggccgtgtcc atctgcatgc ccttggcggt
     3841 gaggccgtaa ctgcgggcgg ccttgaggag gttgctggcg cgcgagccgt cccgcgagac
     3901 accgcaggcg atgcgcagct cctccagcgg cacgtgcctg ccgtagtggc cgaggaccat
     3961 ggcgaggcag gcggcaccac actccacggc ctccatctgg agcacggtcg gcgtgcggac
     4021 ggtccgcgaa cggccctggg gcacggggcg cttgggcggg gcggcgcggc ggcggtgccg
     4081 cgtctcctgg acggcgctca cggcagcagc caatcgacgg gacgctcgtc ggccaggcgc
     4141 accgaggcct cggcgagggt catggaggtg agggagaagg gcgggccgtc ggcggacgac
     4201 cacgcgtaac cgctcttcgt ggcggcggac ttgtccaggg tcaccaggac cgcgaccggc
     4261 ctgccgtcct cggtgaactg ctcgccgagc tggctgtcgc cgaggaagga ggtgatggac
     4321 tgcgcggact gggcgccgcg gtccacggac ttcacatggc cgcgcagcac gccgtactcc
     4381 tgggcgggca ccgactgcac ggtgaggtcc acggcggcgc cctcggggat ggaggccgcg
     4441 ttctgcgcgg gcacgtagac cgtcgcgtac agggggtcct cggggtcggc gaccttctcg
     4501 accgcggcga cgttcgcgcc ggtggagatg atctggccga tggtggcggc gagcgcggtg
     4561 acacggcccg cggcgaccgt gcgcacgacc gtctcgccct cggccgtacg gaccttcagg
     4621 acgggggagt tcgcgggcag ccgctcgccc tgcttcgcca ggaccgcggt gacctgcccc
     4681 gcgacggggc tctggaggat gtaactgccc tgcccgtgcg tgagaacggc gggcgcgccg
     4741 acggtggacg tcaccgatcc ggtgaccgcc catacggcgg ccgcggccat gacgacgacc
     4801 gtcacggcca gcgtgagcca tccctgcggc cgggcgaaac gcaccggaag atcgagctcc
     4861 tccggcgact ggagcttggc gagggcctgt tggcggaact gcaagggact tccctcacct
     4921 cgtgcgggta cggctcgcac ggcatccgaa gagtcccgga gcctggccgg ctccgggact
     4981 cgacgacgca cgcggtgcga tcagagaccg gcgaccaggc tggtgaccgg ggcggtgttc
     5041 agaccggtga caccctcgac ggtgccgacg gccgtgtcga ccaggccgga aaccggggcg
     5101 atgccgtcca ccaggccggt gacggtgccg agggcgttca cggacaggcc gccggagacg
     5161 ttgtccagct cggcgtcgga gatctcgacg gtctcaacct ggggggtgga gttcatgatg
     5221 gaacttccct tcgtatggat atttcacaag gggggagcgg ccccctccgc gtgcccgtgg
     5281 gggacaggcg gacggccgcg accgcgggct gcccggcacc cgttcccgga tgccgcagcg
     5341 gtccgtgcgg tgcgatggat caaagcacgc ggcgggtccg cgcttccaat caaacagccg
     5401 tctcacctgg gcaattgatc ctcaggggcg gtcatccgtg agggtgcgcg caccgcttgt
     5461 cggcgacttc ttcacatgcg tcacggcatc ggctcgtacg cgctcttgcg gggcgggagc
     5521 cgaaagcgac actccgcccc aatggtgtga ccggcggtag ccggttgtga gggagtccgg
     5581 cccgccgtga cttcgttggg cattggatgt gcagattcgc tgaagccagg attccgctct
     5641 tcggccgcaa ccccgtgcga tcaggtgaac gcgttcggtg aggctcagcc cagcagtgcg
     5701 tataccgtgc tcgcgcgggc cgcgatctga cccgtcgtcg cgtcggtcat ggtgatgtcg
     5761 gcgaacgcca tccggcggcc cagcttggtg atcaccgctt cgatcaggac atccgatccg
     5821 gtcaccgcgc gctggaagga cgtggactgc tgcacggtcg tcatcggccc gtacgccccg
     5881 cgcgcggccg acacggcgag cacggtggcg gtgtccgccg cggccatcag ggcctgcccc
     5941 gacagcgccc cgccctcccg ggccaaccgc tgtgaccagg gcagacgcag gacggcgcgg
     6001 tggtcgtcca agccctcgac ggtcaggccc agttcaagga cccaaggggc gaagttgtcg
     6061 gcgaggatct tgtcggcttc agcggtggtc atcgtcatat gggggattgt tcccgccacc
     6121 gcccggcggg acgcggagct tggccgaaac ggtcgtccga ctggactgcg cggaaacgga
     6181 attgaacgca ccgcgtgacc cgtgcgtacc agtggccatc caggcgccca gaaaagccgc
     6241 cggacgatac ggcggcacgt cccccgtccc caggaggtcg agaaggttga gtcacaagcg
     6301 aatgccgaag cgcaaggccg cgatagccgc gggcggtgtg gcggcgctcg gcgcggccgc
     6361 gatcctgctg ccccaggcga acgcgtccca ggacggcgcc tcggacgaag ccgcggcccc
     6421 caggaccctc aaggcggcgg acgcctcgga tctcgcctcg caactcgccg gactgctcgg
     6481 cgacgccttc gccggctcgt actacgacgc cgacaaccag cagctcgtcg tcaatgtcgt
     6541 ccccggcgac aacaacaacg tcatcgtgca ggcgaagaag gcgggcgcga aggtccgcga
     6601 ggtggacaac agcctcgccg agctcgacgc cggcgcgaag accctgaagg cgaaggcgac
     6661 cattcccggc acgtcctggg ccgtcgaccc gcgcaccaac aagatcctgg tcaccgcgga
     6721 cagcacggtc accggtgaca agtgggatca gctggagtcg acggtcgaga gcctcggctc
     6781 cggcatggcc accatcaaga agtcccaggg caccttcaag accttcctgt ccggcggcga
     6841 cgccatcttc gcgggcggcg cgcgctgctc ggcgggcttc aacgtcaccg cgggcgacgg
     6901 cagcccggcc ttcctgacgg ccggtcactg cggtgtcgcc gccgcccagt ggtcggacag
     6961 ccagggcggt gccccggtcg ccacggtgga cgccgagacg gcgaccttcc ccggcacggg
     7021 cgacttcgcg ctcgtcaagt acgacgaccc ggcgacccag gcgccgagcg aggtcaacct
     7081 cggcaaccag accgtcgcga tcagccaggc cgccgaggcc acggtcgggc tccaggtgtt
     7141 ccggatgggc agcaccaccg gtctgagcga cggtcaggtc ctcggcctca acgccaccgt
     7201 caactacccc gagggcacgg tcaccgggct catccagacc aacgtctgcg ccgagcccgg
     7261 cgacagcggc ggctccctgt tcacccagga cggtctggcc atcggcctga cctcgggcgg
     7321 cagcggtgac tgcaccgtgg gcggcgagac cttcttccag ccggtcacga ccgcgcttga
     7381 ggcgacgggc gccaccctgg gcgccggtgg cgcggccggt gacggcggcg cgggccagga
     7441 cgcgggcgcc ggtgacgagg ccggtgcggg ccaggacgcc ggtgccgggc aggacgcggg
     7501 cgccgggcag gacgccggtg ccgggcagga cgcgggtgcg ggccaggagg ccggtgccgg
     7561 tgacgatgcg ggcgccggtg aggacgcggg cctcggcgag gaggtcgaca tgggcgagca
     7621 ggccggacgc cgctcgcact gaccccgtat cagcgtgaca gaccgggtgg ccggcccttc
     7681 ggcgggaggg ccggccaccc atgtcatgcg ggtggcgccc cggaagactt cctgagcggg
     7741 agagtcctcg acggccaccc acgtcagacg ggcggcgcgc cgtcagtcct ccgcccgcag
     7801 caacagcacc gccacatcgt ccgcccgccc ccggggcagc gcggccgact ccaccagatg
     7861 gtccgccagc gcgtccaggg gcgcgtcacc cgccgtcgtc agaaggttgc ccagttcggc
     7921 gagggcgtcc tcgatgtcga tgcccgggga ctcgatcaga ccgtcggtgt agagggcgag
     7981 gacggagccg ggggccaggt cgacctccgt cgtctggtag cccgcggagc cgtcgatgcc
     8041 cagcagcggc cccccggcga gatcgaggac ccgtaccttt ccgtccggcc gtcgcagcag
     8101 cggcggcgga tgccccgctc gggccatcac ggcccggccg cgctccgggt ccagccgcag
     8161 gtacagacag ctcgcgaaca gctcggcgcc caggtcgatc agcagccggt tggtgctgcg
     8221 catgacctcc tcgggcggct gcccgacggt cgtgtaggcc cgtacggccg tacggatctg
     8281 ccccatcaga ccggccgccg tcacattgtg gccctgcacg tccccgatca ccgccgcggc
     8341 ctgcccctgc acgggcacca ggtcgtagaa gtcgccgccg atgtccatgc cctgagtcgc
     8401 cggcagatag cgcgccgccg cctcgatccc gggcagcggc ggcagtgagt gcggcagcag
     8461 cgccgcctgc aggccgtgcg cgagatggtg cttggcgtcg tagagcatcg cccgctccag
     8521 cgcctgcgcg atcagcccgc ccatgctcgt cagcaccgac cgttcgtcgg cggggaaggt
     8581 gtgcggctcg gtgtaggcga ggacgaccgt gcccaccggg cggcccgagg cgatcagcgg
     8641 caggtacgcc caggccgcga acccgtcggg cgtggcctcg cggaccggat acagccgctc
     8701 caactgctgc cggtcctcga agaaggccgg aacccccgtc gtcagggcgt gcgtgcccgg
     8761 agtccgctcg gtcatcggca gtccgtcgaa ctgctccacg aacgacgcgt ccggataccc
     8821 gtggtgcccg agcacatgca gccgccccgc ccgggagccc agcaccacca gcgcctggct
     8881 gccgaccgcc ggggcgatct cgtcggcgac cagctgcacc acgtcctgca caccgaccgc
     8941 ctcggtcagc gaactcgcca ggctcagcaa ctgcgagatc gtcaccagcc gcgtcggcgc
     9001 gtcggcaggt ggccggtgcc tgcggttcat ctcggcgacc gcccgcgccc gggtcacccg
     9061 gacactcagc cccgtcgtac tcgggtacag ccggaacgac agccagtcgg cgggcggacg
     9121 cagcgccacg aacgaggtgg tctgctggct gaacagcgcc gcccggtagc ggtcctcgta
     9181 caccggatcg ttcagccagg gcaccgacgc ccacagctgc gtgcccagca actggctcac
     9241 cggaatcccg atcagctcgg ccgccgccgc gttggcgaaa cagatccgcc cgtgcagatc
     9301 cagcgagcac agcccgtacg gcagccgggc caccatccgc gccgactcca ccgtgcccag
     9361 cgtgccggcc gcgcccgcga gggagggcgc ggcgagcaga tccggctcgg gcagcagcgg
     9421 cacgctgtcc tccagggcgc gcgccagccg ggtggcgagc cggtcgcagg ccgccgccag
     9481 atgggtgcgc tcgcgctccg acagatccgg cggatgcgaa ccgggccagg tcacgaagac
     9541 cgcgccgtag acggtggagt ccgtcgccac cggcagcgcg gccagcgcga acgggtacgg
     9601 cagcaccacc gagatccgcg gatacaggcg ggccatctcc tcctcgccgc tgacccacac
     9661 cagccgccgt tcgcgcgccg cgtccgccac cggcaccgga gcgcccagcc ccacccgctc
     9721 ccagggtgcc gcgaaggccc gggggagccc cgccatcacc gccatctcca gcaccggctc
     9781 gtcggcggcc cgcagataga ccgcgccgga gtgcgcgtgg acctcgtcca tcatcgaggc
     9841 cagcgccagc gacagcagcg gccgtccgac ccgcgtccgc gtggtggccg gcgcctgggc
     9901 ggagtcctgc ccgtcggaca cgccgaccac ctcctcgcac ggccgggcga cgggtccccg
     9961 gaacaaatct cccccctgac gggccggacc gcacggcgag cgctcccggg gcgggccggc
    10021 agagccatcg ttgtcaccgg acgactgtcc cgaacacttg cgtgaccact tgttcggcgg
    10081 gtttcgagca ccgccctccg cgaagattcc atcggacgcg cacaggggct gcgcgggtgt
    10141 ctcattagcg ctgtaatggc gacgtgggtg gcgacggcgc tgcgggacgc agatcgagaa
    10201 gacaccgtgc cgaaga
//
