LOCUS       NZ_CP104098            25209 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces noursei strain IFO14147 chromosome, complete genome.
ACCESSION   NZ_CP104098
VERSION     NZ_CP104098.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9223378)
  AUTHORS   Zeng,X.
  TITLE     Transcriptome and Metabolome Analysis Revealing the Improved
            epsilon-Poly-l-Lysine Production Induced by a Microbial Call from
            Botrytis cinerea
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9223378)
  AUTHORS   Zeng,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2022) College of life science, Huaibei Normal
            University, Dongshan road 100#, Huaibei, Anhui 235000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: PGCGAP v. 1.0.34
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025163575.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 12:09:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,195
            CDSs (total)                      :: 8,101
            Genes (coding)                    :: 7,883
            CDSs (with protein)               :: 7,883
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 218
            CDSs (without protein)            :: 218
            Pseudo Genes (ambiguous residues) :: 0 of 218
            Pseudo Genes (frameshifted)       :: 93 of 218
            Pseudo Genes (incomplete)         :: 149 of 218
            Pseudo Genes (internal stop)      :: 11 of 218
            Pseudo Genes (multiple problems)  :: 33 of 218
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:04:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7002785
            Orig. end                         :: 7027994
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP104098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25209
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="22"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25209
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25209
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15209](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15209)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(68..259)
                     /locus_tag="N1H47_RS30790"
                     /old_locus_tag="N1H47_30790"
     CDS             complement(68..259)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003482.1"
                     /locus_tag="N1H47_RS30790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30790"
                     /product="hypothetical protein"
                     /protein_id="WP_016571603.1"
                     /transl_table=11
                     /translation="MKTCTQFATIRQEYEREIRFLSAHSERHAGRPAAKSSAKHSAWTK
                     TRMARALSGHFNRCLECG"
     gene            complement(256..1728)
                     /locus_tag="N1H47_RS30795"
                     /old_locus_tag="N1H47_30795"
     CDS             complement(256..1728)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571602.1"
                     /locus_tag="N1H47_RS30795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30795"
                     /product="hypothetical protein"
                     /protein_id="WP_016571602.1"
                     /transl_table=11
                     /translation="MTHLSLLVDSPPDLSALLAVGAPLTAIALALTSWAIRRKGTAVKK
                     RLGDPAVVVAALAAVGCTAYSADTSWRFAADYLDVAGTLERVMLFSAAELGLFATALMA
                     RKNLATQGAPGLPGTLVWVITSVQIIPAYAESGPVGGTVRAFVGPIMAALLWHQAMGIE
                     LRLRTPGAASTGLIATLGREARQRLLSRLGIAAQARDAAQITRDRATVRAAELATRLAN
                     RAPAKRTNRHGRRLTRRLEKVIGRAEVGTDPQQRGELLGQLAARRHAPALATIPLRPPW
                     GITPQSEGAASLPPQHEHSTVVPNNDPCDEAQPIAERGPCSRRGPVPSNCGIAVEADSG
                     TGDRGAGTEPEAGDQGPSASTTGTEPTGDRGPTTPTTGTEPTGDRGHAVPLRRKPTTKP
                     KSRSNRGSRSRGPQRQRPADAPEQSVEQLVQQVRPYVPALLERDGNVAVTRVQLREILR
                     REGLKGARNDRLALVLQQLRSEDSSAKARSTR"
     gene            complement(1725..2372)
                     /locus_tag="N1H47_RS30800"
                     /old_locus_tag="N1H47_30800"
     CDS             complement(1725..2372)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070650.1"
                     /locus_tag="N1H47_RS30800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30800"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_016571601.1"
                     /transl_table=11
                     /translation="MRHITSHIAPATGLRGIADTSWHPHGACHGMAPEDADATFFPLPR
                     DHDAIEEAKELCSMCPVRHDCLNYALENRLKDGIWGGLTEAERRPWHDGLPQRLDYRRV
                     IAFFNGRDVHLTEAERQIIVDHAYVRGWRPYRLAGALKISNKHARDLLKDAANKVFDRD
                     LKLGVPPRPKQKKPQEKKAVQAPTTSHTRAGAPAKRQPVQSTSARAPHGKAA"
     gene            complement(2500..3210)
                     /locus_tag="N1H47_RS30805"
                     /old_locus_tag="N1H47_30805"
     CDS             complement(2500..3210)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571600.1"
                     /locus_tag="N1H47_RS30805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30805"
                     /product="hypothetical protein"
                     /protein_id="WP_016571600.1"
                     /transl_table=11
                     /translation="MTPHEIGALLAYIGRLDPRLSRADTGEARDQIAQWHELLGDVPPA
                     TAHGWDARVTARDHILDSPYPIMPVDIARKWRVYRRDRLQRHTDPLPSASPDDQAAWAA
                     ELRGTRLAVATGVAAPTRHRELTGSEFEPERQGRLREIGSCIPPHIREALSPYRPARAA
                     REAAIAQGQPDVLGVRCEHCHAEVNEPCRSRRLGLDGQPRANAPRSTPHPSRVDLAATQ
                     QVQQSVMACPALFP"
     gene            complement(3207..4136)
                     /locus_tag="N1H47_RS30810"
                     /old_locus_tag="N1H47_30810"
     CDS             complement(3207..4136)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571599.1"
                     /locus_tag="N1H47_RS30810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30810"
                     /product="hypothetical protein"
                     /protein_id="WP_016571599.1"
                     /transl_table=11
                     /translation="MSVDAREWGWEHSSSKGVARLVLLSIADRVPDEKCVAWASLASLV
                     TRTNASRTAVRTALAALAESGELELLDYLDGPQRASVYRLPHAAAWLAKVAKATKDDPD
                     AYVAPPTDSDPVPELDEEAETQLRRYGIWPKKGKDSDPSRRNLTGAESDPPRRNPPPRR
                     AGIRTAGRTDSAPQNRSEPKVNRNSSSSGGAAAIPVDQWQIDTATQAWAHQHGHLDRLG
                     EEGLLASDAKWRVHRANWQPRKVAAWAADWRSWIARERSPAPGRPNLYAVPGNGGTTGT
                     GRMTRAEAHTAALLAALGEPTENGAAAQ"
     misc_feature    4517..4530
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.43"
                     /tool="antismash"
     misc_feature    complement(4519..4532)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.45"
                     /tool="antismash"
     misc_feature    complement(5103..5116)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            5240..6574
                     /locus_tag="N1H47_RS30815"
                     /old_locus_tag="N1H47_30815"
     CDS             5240..6574
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.5"
                     /locus_tag="N1H47_RS30815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30815"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_158694330.1"
                     /transl_table=11
                     /translation="MKGKTISMAKRSPGNREDGAKDEPLPGRLMGLAGLLRAWRAAASH
                     RLGRAVTQRELGEACGRSERWYRMLESGAHTRLKRDQCDILSELLLLGRDEQQALVLYS
                     TGGAGSVTPAPGYDSPTRRALQALLDQQMPNPTWLLDAHWNVIGYNEAMASWCPWVMEP
                     GANLLRWALLSEEARTTFVDWSKHAVEYLAMLRFSLLQYPQNAELGALLADVTKDPELA
                     HLWETRSEVTEARGAFYYRVSLPAHNYEIVELESQTLFPAALPDCRLVILNWIQRDDSD
                     GDTGSATRPAVEEARSQPSASPLPGQVTAGTADEAAKYAGPGAVALPILSELIGTGCQL
                     TYSPTNRTVIWATPQHDGRWDVAEVNPYTVVVRMPQAIHVEGATAEYKLLTRAVLPAEP
                     ADAVQRIREMTAQLRRRIGILEEIHRDELEADRSLPYGWNPVDDD"
     gene            complement(6725..7471)
                     /locus_tag="N1H47_RS30820"
                     /old_locus_tag="N1H47_30820"
     CDS             complement(6725..7471)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS30820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_30820"
                     /product="hypothetical protein"
                     /protein_id="WP_016571597.1"
                     /transl_table=11
                     /translation="MTREVLDGAIKRIGPPTLCGGDATGPVVRWRDDQRTLLLDHGQQA
                     LRLCVRRTSELEAEERARFAPCQQSDPVGFYTGLPYVWQLYGGGVGSPPLGFPAVPPAP
                     DWSWLEGSLAQLLSGWWEQVPVQLGYGDAVGFNIDFRGEDQHSVERVSVMCEEPGGLVL
                     LVDDRAVPGGTPEDVMRARGWRQRIMGWWQRDFEDDGADGAARAAKMVVEELLLRGARS
                     PDALKVTDVRAERGGLLALPGLAIAR"
     misc_feature    complement(7607..7622)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.27"
                     /tool="antismash"
     gene            8066..9097
                     /gene="galE"
                     /locus_tag="N1H47_RS30825"
                     /old_locus_tag="N1H47_30825"
     CDS             8066..9097
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571596.1"
                     /locus_tag="N1H47_RS30825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30825"
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_236664372.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.9e-11, bitscore:
                     41.5, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.7e-05,
                     bitscore: 22.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLERSQGEGNVVVKVLIAGGAGYIGSTVASACLDAGITPVILDN
                     LVQGRREFTEGRTFYEGDIADGALVDRIFAEHPEISAVVHCAALIVVPESVADPIGYYE
                     ANVAKSLAFVRHLHRNGCDRIIFSSSASVYQAEDGTPVNEDSPLAPQSPYARTKAVCEE
                     MFADIAVAGPRVLSLRYFNPVGADPKLRTGLQLKRPSHALGVLIQAHQESRPFPITGTN
                     YPTRDGSGIRDYVHVWDLAAAHIAAIERFDSILTGAKRSIAINLGTGSGTTVRELCEAF
                     NNVVSTPLVTIDADPRPGDVAGGYTKSDRAAELLGWTPKLSLEDGIRSALDWIPVRDKL
                     LKD"
     gene            complement(9295..9873)
                     /locus_tag="N1H47_RS30830"
                     /old_locus_tag="N1H47_30830"
     CDS             complement(9295..9873)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571595.1"
                     /locus_tag="N1H47_RS30830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30830"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_016571595.1"
                     /transl_table=11
                     /translation="MEATISSGPDPILWLATDTCALGPYRADLVETYWRWEQDPALLVG
                     YGRQSPESLEARTEGMNHQLRGENIRFTIYDRTSGKPVPAGVATLLPDHAVRTAEYIVM
                     IDPQARGRGLGTQATRLTLDYAFHITNLRMVWLKVLAPNTPAIRAYERAGFRDAGLLRN
                     AGYWLGQVCDERIMDTLAEEFTGHSLVQP"
     gene            complement(10001..10984)
                     /locus_tag="N1H47_RS30835"
                     /old_locus_tag="N1H47_30835"
     CDS             complement(10001..10984)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571594.1"
                     /locus_tag="N1H47_RS30835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30835"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_016571594.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-39, bitscore:
                     135.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVDRLTPIDRAVLDVLAGHPLDEIARRAHMHPAHLADAVELFQQ
                     AGHDALAHQTSTLGWQQIFIEFPDWSAAESTAATLLEPVLSQAQEAGTLTGWWFIRKHP
                     CWRLRLHPRPDSTAVADVSAALDRLREHHHVKRWWPGIYEPETAAFGGALGIDTAHELF
                     VVDSREILRLPDRPDGALGRRELSVLLCSAMMRGAGLEWYEAGDVWDRVISDEGRSAAE
                     QIPEERRLQLVQQLRTLLQASTAPAGPNLAADGPLRPVATWVSAFRDTGAALGAAAHAA
                     RLERGLRHVLALHVIFHWNRIGLSHRTQSALAWSARQAVFTPLERS"
     gene            complement(10966..12195)
                     /locus_tag="N1H47_RS30840"
                     /old_locus_tag="N1H47_30840"
     CDS             complement(10966..12195)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571593.1"
                     /locus_tag="N1H47_RS30840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30840"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_016571593.1"
                     /sec_met_domain="LANC_like (E-value: 1.6e-43, bitscore:
                     147.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKAQAAHIASRCATVLSGPRPGQNFEGQSLADGAAGIALLHIE
                     RAQARTGPWKLAHRWINHAAAGELDATDTAGLFRGVPALAFVLLNTVPHGRFHELYRTA
                     WEKLHHHVTTLAHQRTERALARIHRGELTTFAEYDLFCGLTGIGAYLLRADPTSSALEQ
                     VLRYLVALTHPVAINGHRLPGWWVAHDPNRGTSAEFAQGHANLGVAHGITGPLLLLAQA
                     LRRGVSVDGQHEAIDAICSHLDAWRQDGERGPWWPLHLTLDEFSSGRTHQRGAGRPSWC
                     YGTPGIARAGQLAGIALGDRGLQHMYEVALYLSLTDPEQLALIRDTSLCHGWAGVYQTT
                     ARAAHDSPYPHLRQLLPRLGETLTTHLRTTADHNAGLLTGNAGCALALSSLTTGAPITQ
                     TGWDACLLID"
     gene            complement(12192..15209)
                     /locus_tag="N1H47_RS30845"
                     /old_locus_tag="N1H47_30845"
     CDS             complement(12192..15209)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141308.1"
                     /locus_tag="N1H47_RS30845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30845"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_045788553.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.7e-188,
                     bitscore: 625.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1e-12,
                     bitscore: 47.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-09, bitscore:
                     37.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRATTRPGVVSLPRGLGDSAVARAWLGSVWQDADVRGALQVATP
                     VLCRAVESIVGGVQKRPRQIQRTVLSVASYLLRWQHRATPFGLFAGIAPLTVGPAALVR
                     WHGSPRATARADAAWLAEVIRQLHCHIAVVERLSVVANETAVVRGDRVVAAGPPADGRA
                     VLMAPVEVSVPARRTVLAALTAAAVPLSYRELRDQMRAQFPNACAGQVDGLLGDLIAQH
                     LLVSSLWAPMTTVDALAHVCAELKRIGAHALPGVGPLVRELDGIHATVSIEAPSSGVLV
                     DVAERMHALCDQVIAPAPLLVDTTVDGHVQIPHSVVSEVQSAVAALYRATPHPYGHTAW
                     RDYHRRFRARYGVGASVPVLDLVGDHGLGLPATYVGAEREKSVQPWTNRDEKLLARLQQ
                     VLMDGREELVLTDADIDELARVTGSEEPEFAPRLEVAFEVHAASTRELARGRFEVWVTS
                     VPRPTNSMAGRFACLLPQEDREALARTYRPSSEETVTAQLSFTPRRHRNANISRTVQLL
                     PVLPLAEHRPDGDKEVITLADLAVTADARHLHLVQRSAGRRVELHIPHVLEAGIQTPPL
                     ARFLAEVSTVRCAVYCPFSFGAASRLPYLPRVRYRRTVLAPARWLLTATDLPARTAKMP
                     QWEEALTAWRRRMRVPARVALVELEQRLPLDLTHPVHRYLLRSRLDEAKRLELREAPEP
                     DRHGWIGRAHEILLPLRRTQPQQSLPLPAPQHPVDGANAQFPGAGVVLRAHLHSHPQRH
                     DEILDRHLPALLARFDQPPRWWFLRHREASRPEAGRHLVLVLHLPEGTYGSAADLVHAW
                     ATALHRAGLIADLTLSSYTPQTGRFGHGPALDAVHGVFAADSAAALAQIRYVAHDDALA
                     PEALTAASLLNLATHLAPTTDTGLHWLITHLPQEHGPLDRALREQTLTATQPGATFPFT
                     TTAHGTSVTVAWEARAAALAAYRSTLVGQRDPLTVLRSLLHAHHIRALGPDPKAEALTL
                     RLARTSALSHTARRTT"
     aSDomain        complement(14517..14795)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_N1H47_RS30845_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.50E-15"
                     /identifier="RREFam001.1"
                     /label="N1H47_RS30845"
                     /locus_tag="N1H47_RS30845"
                     /protein_end="231"
                     /protein_start="138"
                     /score="47.4"
                     /tool="antismash"
                     /translation="VVANETAVVRGDRVVAAGPPADGRAVLMAPVEVSVPARRTVLAAL
                     TAAAVPLSYRELRDQMRAQFPNACAGQVDGLLGDLIAQHLLVSSLWAP"
     gene            complement(15339..15527)
                     /locus_tag="N1H47_RS30850"
                     /old_locus_tag="N1H47_30850"
     CDS             complement(15339..15527)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571591.1"
                     /locus_tag="N1H47_RS30850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30850"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_016571591.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 6.6e-15, bitscore:
                     53.6, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHTALLDPMEVDGEEDFAPLDVKVVVAAHPHGKLLCATNDGCGN
                     TCANGASACTSFTEDPA"
     gene            complement(15578..16792)
                     /gene="fxlM"
                     /locus_tag="N1H47_RS30855"
                     /old_locus_tag="N1H47_30855"
     CDS             complement(15578..16792)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571590.1"
                     /locus_tag="N1H47_RS30855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30855"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_016571590.1"
                     /sec_met_domain="PCMT (E-value: 2.6e-38, bitscore: 130.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVDTEQATTLRNTVMDQLRADGVLVTPEVEAAMRKVPRHAFAPE
                     APLEKVYEPYAAVVTKTDEYGVQISSVSAPQIQAMMLEQAKLQPGMRVLEVGSGGLNAA
                     YMAELVGDGGEVTTVDIDPEVTERGRRLLDEQGYKSVRVVTADAAEPIPGLGEVDVIMV
                     TAGAWDVPVAWLDQLAPEGRLVVPLRMRGLTRSVAFVRRGGHLESESAKICGFVPMQGA
                     TAHEVKLLLVASSPEIGLRFDDGIPIEPSQLDNAVTTPRVELWTGVTIGRGELLDTLQM
                     HLAIGLPGFCIMVLDKELDSGIVAPTNPGFSLAAVENDSFGYVIYRRTADGENSEFGVH
                     ALGAHAQQLAEEMAQQLRTWEASRRGGPSPVIRVYPANTSDDQVHGDRVIDKVHCRISL
                     SWPTH"
     misc_feature    complement(16781..16795)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(16829..16845)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    complement(16976..16990)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     gene            complement(17349..17792)
                     /locus_tag="N1H47_RS30860"
                     /old_locus_tag="N1H47_30860"
     CDS             complement(17349..17792)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039985.4"
                     /locus_tag="N1H47_RS30860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30860"
                     /product="DUF6082 family protein"
                     /protein_id="WP_016571589.1"
                     /transl_table=11
                     /translation="MKTSHALLVLAAVGAVHVAQRERHQNQRSQVAVAQLHHSRIAQLV
                     ANPDLAQDWAPKGMDSGQFAQLLSENQQMVVLSLRHRLGLLRGRRLRFVANKIMERESG
                     RRYWKHFGADRAQEAEGNPCAQRFTEAMQTAFLAHYAAKPAGV"
     gene            complement(17964..18719)
                     /locus_tag="N1H47_RS30865"
                     /old_locus_tag="N1H47_30865"
     CDS             complement(17964..18719)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS30865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_30865"
                     /product="hypothetical protein"
                     /protein_id="WP_016571588.1"
                     /transl_table=11
                     /translation="MTVAVKVASGENAARALVREAAALRTMPPGGIRVLHTADNVSCPA
                     PWAWLVTPWADGPTTWDACKKLRDTTEGGRAEARCAAVELCMAVGRLHTAGWVHGDLRP
                     HHAVHTTAGVRLLSCTGASRIGNAVSATYLGGLVHLLSPRLAAALEPTAASVMLDPDDE
                     IYTLAAGLWWAATTTWPLAYADAGLDSSTMSALALRRAIATAKIPLAKAAGHPWPEFLA
                     PLTAAMAQPPGSRPSALQLADQLKAVPLT"
     gene            complement(18909..19832)
                     /locus_tag="N1H47_RS30870"
                     /old_locus_tag="N1H47_30870"
     CDS             complement(18909..19832)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS30870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_30870"
                     /product="hypothetical protein"
                     /protein_id="WP_124428207.1"
                     /transl_table=11
                     /translation="MTSSIASGLKASLRTPFAATILANRLAGSPAIWRLCRSEPSTHLW
                     QVGGPQSSVAVKVAAGERAALTLVRETENLRAMPAGNLRSLGAGSDLRPTDPIAWQITP
                     WALGLTTWEAFRLLREGDQEGREQARAVAIETCRAVGRLHTAGWLHGTLDPHHVVHTRE
                     RSRVRLLSCAWATRAGRRTSPGYGGGLVHLLSPELANAIDRSRGNGLLLSRPAEVYTLA
                     AGLWWAVTGTWPLAYDDFRGVGFDPQTKSRPHLLRIIASGEVPRADPAVHDWPEFLEPL
                     AGAMSPSLSRRPTAHQLADWIESIPL"
     misc_feature    complement(19065..19067)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(19479..19481)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19829..19990)
                     /locus_tag="N1H47_RS30875"
                     /old_locus_tag="N1H47_30875"
     CDS             complement(19829..19990)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS30875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_30875"
                     /product="hypothetical protein"
                     /protein_id="WP_157846724.1"
                     /transl_table=11
                     /translation="MRATLREADRRLPLPPPLALPQAVVRAQGLGRLIEALDRALCLLR
                     DEEAEVFT"
     misc_feature    complement(19971..19984)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.33"
                     /tool="antismash"
     gene            complement(20191..20658)
                     /locus_tag="N1H47_RS30880"
                     /old_locus_tag="N1H47_30880"
     CDS             complement(20191..20658)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571585.1"
                     /locus_tag="N1H47_RS30880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30880"
                     /product="hypothetical protein"
                     /protein_id="WP_016571585.1"
                     /transl_table=11
                     /translation="MRTTTPARVTLAPRERQALEGLADGSMLAAVALRLSIREGTASGY
                     LKGAKRKLYGVRESAAALAVGYTTKAISRPSLLDPETLLLPDNQQDIVPLLARGMTASC
                     MAAELKRPVDIIRRDNRDLLTNLRAKNRVHAVKRLWELQLLTAGQVTAWLY"
     gene            complement(20655..20780)
                     /locus_tag="N1H47_RS30885"
                     /old_locus_tag="N1H47_30885"
     CDS             complement(20655..20780)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS30885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_30885"
                     /product="hypothetical protein"
                     /protein_id="WP_260222713.1"
                     /transl_table=11
                     /translation="MRKVQRRGLLRNSVLPFDTGDLLPDGQDIAPVRHQAMAEAA"
     gene            complement(20777..21616)
                     /locus_tag="N1H47_RS30890"
                     /old_locus_tag="N1H47_30890"
     CDS             complement(20777..21616)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571584.1"
                     /locus_tag="N1H47_RS30890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30890"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_037633407.1"
                     /transl_table=11
                     /translation="MRAVIWNLYLGGVDGASEERLQKQAKILLRLNADIVCLPECNRWD
                     EDGERRLCWMADTLGLQPVAMIRSRLGTPPVQNHTALLYRPSTLRLLDRAVLGRDVFHH
                     ALIRARLRPVEESDDRRDFLVLATHLSWRNGKTRLDEASWMTDYGGKFPGMPPRGILLA
                     DLNVPDREPPNSDWSLIPRNMHSRYRKIREDGSFGDVDQDALQLLLNSGWQDPQTLTGV
                     QRAPTVGYAYPDEPVEWCLDYALVHGMTVTSYRTHDTPQARKASDHLPVVADVKVRP"
     gene            complement(21616..21768)
                     /locus_tag="N1H47_RS41505"
     CDS             complement(21616..21768)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039316.4"
                     /locus_tag="N1H47_RS41505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5999 family protein"
                     /protein_id="WP_157846725.1"
                     /transl_table=11
                     /translation="MCAHTPPCPTADAADRQAAQSKVHHPEQGRRANCTNPLRGTLIHR
                     RRDGA"
     gene            complement(21818..22282)
                     /locus_tag="N1H47_RS30900"
                     /old_locus_tag="N1H47_30900"
     CDS             complement(21818..22282)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571583.1"
                     /locus_tag="N1H47_RS30900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30900"
                     /product="DUF6302 family protein"
                     /protein_id="WP_016571583.1"
                     /transl_table=11
                     /translation="MLITTTSTASPFTVSLRPAAEAYDFDYFRERLAEPEILAHAVAVR
                     VFRAPLLAVPVGGSRRGGYLSFDLLSLAMAARSLLKDRPGFPRLRVRWSPYRDTCHTVE
                     WGDPAPDWWVADAVAGHFYGYREEAIAAFIQKHPQTPSSATFEPYSPTAS"
     gene            complement(22276..22815)
                     /locus_tag="N1H47_RS30905"
                     /old_locus_tag="N1H47_30905"
     CDS             complement(22276..22815)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039764.4"
                     /locus_tag="N1H47_RS30905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30905"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_124428208.1"
                     /transl_table=11
                     /translation="MVRAEFGGVLMASTTVHWDERPGSAPVRVKDPSVPTNPCISPPDV
                     QDVRRVLSRLRTWEPVDWDEVYDDLDTVLGDEVSHHAAGTSVGSPLPEYDALEGLAERF
                     RPALIQLVTRGLRNGAHRKHRDIAVLIEQAQGLIPEELPADAWQAVVLLRKLARVTLGL
                     AERLEDTGIAKGLVEC"
     gene            complement(22785..23198)
                     /locus_tag="N1H47_RS30910"
                     /old_locus_tag="N1H47_30910"
     CDS             complement(22785..23198)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571581.1"
                     /locus_tag="N1H47_RS30910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30910"
                     /product="ATP-binding protein"
                     /protein_id="WP_045788554.1"
                     /transl_table=11
                     /translation="MEERFSITKRSPGERPPPEDESRVSAMRLVTRERLTSRGLTCVVD
                     DTTLVVSELITNAIVHSGGRQIRLTLDVCDDVLCIRVHDGVPGPRLSAQCPGDDEHGRG
                     LLLVQEIARNRQGAWGVSDNGASTWCELSLAAC"
     misc_feature    23354..23370
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.87"
                     /tool="antismash"
     gene            complement(23434..23682)
                     /locus_tag="N1H47_RS30915"
                     /old_locus_tag="N1H47_30915"
     CDS             complement(23434..23682)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS30915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_30915"
                     /product="hypothetical protein"
                     /protein_id="WP_020963602.1"
                     /transl_table=11
                     /translation="MTTSHAQTGAGAASLPPAKRHLRLACEAEVAHTEAGRFAVPLDLH
                     EGAAEPATIPLVLTADEAVALHSRLGALFPFAEGDDR"
     misc_feature    complement(23638..23640)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(23723..23732)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.26"
                     /tool="antismash"
     gene            complement(23844..24983)
                     /locus_tag="N1H47_RS30920"
                     /old_locus_tag="N1H47_30920"
     CDS             complement(23844..24983)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.5"
                     /locus_tag="N1H47_RS30920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_30920"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_260222714.1"
                     /transl_table=11
                     /translation="MVYDGELFSIGQRIKWWRERRGLSQRMLGDLIGRSENWVYKIEND
                     RMPLDRLPILIALSKQLRCSLEDLTGGYVSEIVTAGTEHEHVPLIRQALSLPASLLPQR
                     IGSVASDDFESSVTDAWKVYETQADDRYRDVGERLPTLLRQGHAALRDASPEQEGTVLR
                     QLISLYGLHQIWLRRVGEPTLARIAADRGLSLADNAGDPALLAAAAWNLACVLTSAGDV
                     EDSYELAQQTIAQCRPHDDSNPGHWSAYGALHLQGAVAAVRAAKGPRAWDLYHGAQQAV
                     ARVGADLNHWHTCFGPTNFAMHEVHLKAEEGDTGEALRAADHVLVNEEVPLERRTRYLI
                     EVMNLNRIQRDDYATVHILGKLLKQSPEEIVFSPWSGRR"
ORIGIN
        1 gggtggtccg gcttgggccg gaccaccgat tacgtgatga gggcgtctac ctgcggcttc
       61 gcgagggtta gccgcattcg aggcagcggt tgaagtggcc gctgagggct cgtgccatgc
      121 gtgttttcgt ccatgcggag tgcttcgcgg aggatttcgc cgccggtcgt ccggcatgcc
      181 gctcggagtg ggcgctcagg aagcggatct cccgctcgta ctcctggcgg atggttgcga
      241 actgggtgca ggtcttcacc tggtgctcct tgccttggca ctgctgtcct cgctccgcag
      301 ctgctgcagg acgagggcca gtcggtcgtt cctggcgccc ttgaggccct cgcgccggag
      361 gatctcccgc agctgaaccc tggtgacggc gacgttgccg tcccgttcga gcagggccgg
      421 gacgtacggg cggacttgct gcacgagctg ctccaccgac tgctctggtg cgtctgctgg
      481 ccgttgccgt tgcggaccgc gggaccggct gccgcgattg ctcctgctct tgggcttcgt
      541 agtcggcttc cgccgcagag ggaccgcgtg tccccggtcc ccggtgggtt cggtcccggt
      601 ggtgggggtg gttggtcccc ggtccccggt gggttcggtc ccggtggtgg aggcgctcgg
      661 tccctggtcc ccggcctccg gctcggtccc cgcgccacgg tcgccggtcc cgctatctgc
      721 ctccacggca atgccgcagt ttgaggggac cggtccccgc ctgctgcacg gtccccgctc
      781 cgcaatcggc tgcgcctcgt cacagggatc gttgttgggg accaccgtgc tgtgctcatg
      841 ctgtggcggg agcgacgcgg cgccttcact ttgcggggtg attccccacg ggggacgcaa
      901 ggggatcgtg gcgagcgcgg gcgcgtgccg ccgtgccgcg agttggccca gcagctcacc
      961 gcgctgttga ggatcggtgc ccacctctgc tcggccgatc accttctcca gccgtcgtgt
     1021 gagtcgacgt ccgtgccggt tggtccgctt ggcgggagca cggttggcga gacgggtggc
     1081 gagttccgcc gctcgcacgg tggctcggtc gcgcgtgatt tgcgccgcgt cgcgtgcttg
     1141 ggcggcgatg ccgaggcggg agagcagccg ctggcgcgcc tcgcgcccca gggtcgcgat
     1201 cagcccggtg gaggcggcgc cgggagtgcg cagacgcagc tcgatcccca tggcctggtg
     1261 ccacagcaac gccgccatga tcgggccgac gaaggcacgg actgtaccgc cgacggggcc
     1321 gctctcggca taggcgggga tgatctgcac actggtgatc acccagacca gcgtgcctgg
     1381 cagccccggt gctccttggg tggccaggtt cttgcgggcc atcaacgcgg tggcgaagag
     1441 cccgagttcc gcggcgctga acagcatgac gcgctcgaga gtgccggcga cgtcgaggta
     1501 gtcggcggcg aagcgccagc tggtgtccgc gctgtaggcg gtgcagccga cggcggcgag
     1561 cgcggccacc acgaccgcgg ggtcgccgag acgtttcttc acggctgttc ccttgcggcg
     1621 gatcgcccag ctcgtcaggg cgagggcgat ggccgtgagc ggggcaccga cggcgaggag
     1681 ggcggacagg tccgggggcg aatcgacgag cagggagagg tgggtcatgc ggcctttccg
     1741 tgaggggcgc gagcggaagt cgactgcact ggctgcctct tggcaggcgc gccggcccgg
     1801 gtgtggctcg tggtcggcgc ctgtaccgcc ttcttctcct gcggcttctt ctgcttgggc
     1861 cgcgggggca cgccgagctt gaggtcgcgg tcgaagacct tgttggcggc gtccttgagc
     1921 aggtcccggg cgtgcttgtt gctgatcttg agggcgccgg cgaggcggta ggggcgccag
     1981 cctcggacgt aggcgtggtc gacgatgatc tggcgctcgg cctcggtcag gtgcacatcg
     2041 cgtccgttga agaacgcgat cacccgccgg tagtcgaggc gttggggcag tccgtcgtgc
     2101 cacgggcggc gctcggcctc ggtcagccca ccccagatgc cgtccttgag ccggttctcc
     2161 agggcgtagt tgaggcagtc atggcggacc gggcacatcg agcacagctc cttggcctct
     2221 tcgatggcgt cgtggtcccg gggcaggggg aagaaggtgg cgtcggcgtc ctcgggggcc
     2281 atgccgtggc acgcaccgtg cgggtgccag ctggtgtcgg cgatgccgcg caggccggtg
     2341 gctggggcga tgtgggatgt gatgtggcgc aaggtatctc cgtggcagcc gcgttggcgc
     2401 accgggcggt cgatgcggga cgcggcgtcg gtgctggctt cggcgcgggg tgtgccgtaa
     2461 ccggggagtg gatggggcac accgggcggg gcgggtgcgc taggggaaga gagccggaca
     2521 ggccatcacg gactgctgca cctgctgggt ggcggcgagg tcgacacggc tggggtgtgg
     2581 ggtggagcgt ggggcgttgg cccggggctg tccgtcgagg ccgagacgcc tgctgcggca
     2641 cggttcgttg acctcggcgt ggcagtgctc gcaccggacc cctagcacgt cgggttggcc
     2701 ctgggcgatg gctgcttccc gtgccgcgcg ggcaggccga tacggcgaca gagcctctcg
     2761 gatatgtggc gggatgcagg agccgatctc ccgcagccgc ccctggcgtt cgggctcgaa
     2821 ctcactgccg gtgagttcac ggtgccgagt gggcgctgcg acacctgtgg ccacggcgag
     2881 ccgggttccg cgcagttcgg cggcccaggc agcctggtcg tccgggctgg cggacggcag
     2941 gggatcggtg tgccgctgaa ggcggtcgcg ccggtacacc cgccacttgc gagcgatgtc
     3001 cacgggcatg atcggatacg gcgagtcgag gatgtgatcg cgagcggtga cgcgggcgtc
     3061 ccacccgtgg gcggtggccg gcggcacgtc accgagcaac tcgtgccact gggcgatctg
     3121 gtcgcgggcc tcgcccgtgt cggcccggga gagtcggggg tcgaggcggc cgatgtaggc
     3181 cagcagggcg ccgatttcat gtggagtcac tgggctgctg ctccgttctc ggtcggctcg
     3241 ccgagggcgg cgaggagggc tgcggtgtgg gcctcggcgc gggtcattcg gcccgtgccc
     3301 gtggtgccgc cgttgcccgg cacggcgtag aggttcggac ggccaggagc ggggctgcgc
     3361 tcgcgggcga tccaggagcg ccagtcggca gcccaggcgg cgaccttccg cggttgccag
     3421 ttcgcgcgat ggacgcgcca cttcgcgtcg gaggccagca ggccctcctc gccgagccgg
     3481 tcgaggtgcc cgtgctgatg ggcccatgcc tgagtggcag tgtcgatctg ccactggtcg
     3541 accgggatgg cggcagcacc accactactg ctgctattcc ggttcacctt cggttcacta
     3601 cggttctggg gtgcggaatc cgtacggccg gcggtacgga ttccggcacg tcgagggggc
     3661 ggattccgtc gcgggggatc agattccgca ccggtcagat ttcgccgcga cgggtcggaa
     3721 tccttcccct tcttgggcca gatcccgtac cgccgcagct gggtctcggc ctcctcatcc
     3781 agctcgggta ccgggtccga gtccgtgggg ggcgcgacgt acgcgtcggg gtcgtctttt
     3841 gtggcctttg cgaccttggc cagccaggcg gcggcatgcg gcaggcggta gaccgaggcg
     3901 cgctgcggac cgtccagata gtcgagcagt tccaactcgc cgctctcggc gagcgctgcg
     3961 agtgcggtcc gcactgcggt gcgcgaggcg ttggtgcgcg tgaccaggct ggccagggaa
     4021 gcccaggcga cgcacttctc gtccggcacg cggtcggcga tcgacagcag gaccaggcgc
     4081 gctaccccct tgctggagct gtgttcccac ccccactcgc gggcatcgac actcatcggc
     4141 cactcccgtc cacgagggct accgagcgtg ccctcgcagg ctcacgacgg cggaggggcg
     4201 ctgccgcgta gagcgtgtct ccgagccttt cgggcagggg acaagacatg caagaatctc
     4261 cttggtgttg ccacgctgag gtgtcccgtg cgaagggttc agcgtggtga tgatgggcac
     4321 gatccgcttt taggcgggtt ggccgttcag tgatcggcgt ccgagagttg ccgctctcgg
     4381 gcgccgtcgc tgtattcgag ttacgtcact cggcagagtg ggctcctgcg catttgcgtc
     4441 cttcgcggca gcggtgactc gccggggttc cggcgaggga cgacgaacat acgcatgggc
     4501 ccccgtcaag atccagagtt tgctctaaaa ctctccacta ctcgtcagcc agaggtattg
     4561 gccagtgatg tgggcaaagc ggcgagtgcc ccacgggtgt cgttgagcgc cagtgcgcct
     4621 ttgtcttggg aggcgtgcgt cacagagcgg gaggtgacgg gcggatgcgc gctgtaatga
     4681 gcgccgtgtc gattctgtcg aacaagacga aggcacgatc cgctccttcc cgtgtgctgt
     4741 cgggagagcc ccccctgcaa agtgtcgaac gcggacgatt taagtcgcac ttaccgtggc
     4801 cagtcaatcg gccgaaacac cggtcgacgc gcgtagatcg aatgacgggt gcgagttgcc
     4861 ggggcgactc ctgaagggta agtcgtcggc tctggtgtgc agctgagtag tagtcacgcg
     4921 ttgcggaacg ccggttatca cttgacgatc accggcggcg agcgtcagaa aaacaaggac
     4981 cgtcaatttt tttgccggtc agaccggcaa aaaaattgac ggtcgtaatg cccgaatcgt
     5041 gcccgaacgg atggcgatgc cttttacgcg cgaggggtaa attccagccc ctcattcttc
     5101 ttgtgatctg ggtcatgtct tcgcgttcga gcgagcaagg cgccctgcca agatcaaaag
     5161 tgattgcgta aagtcgcctt tgatgtcggt gggcgccgat aggatgcccc tctgccgtct
     5221 cggggaacga caactgcgta tgaaaggcaa aacgatctcg atggctaagc gatccccggg
     5281 aaacagggaa gacggcgcga aggatgagcc gctgcctggc cggctcatgg ggctcgcggg
     5341 acttctgcgg gcatggcgcg ccgccgcgag ccaccgccta ggccgggcgg tcacccagcg
     5401 ggaactcggc gaggcttgtg gacgcagtga gcgctggtat cgcatgttgg aatccggcgc
     5461 gcacacgcgc ctgaagcgcg accagtgcga catcctgagc gaactgctac tcctggggcg
     5521 cgacgagcag caggccctcg tcctttacag cacgggcggt gccggctccg tgactccagc
     5581 gccggggtac gactcgccca cccgccgagc gctgcaggca ctgctcgacc agcagatgcc
     5641 caaccccacc tggctgctgg acgcccactg gaacgtcatc ggctacaacg aagcgatggc
     5701 gtcctggtgc ccgtgggtga tggagcccgg cgccaacctg ctgcgttggg cgctgctgag
     5761 tgaggaagcc cgaactacct tcgtcgactg gtccaagcat gcggtcgagt acctggcgat
     5821 gcttcgcttc tccctgctcc agtacccgca gaacgccgaa ctcggagccc tgctggcgga
     5881 cgtcaccaag gaccccgaac ttgcccacct gtgggagaca agatccgagg tcaccgaggc
     5941 acggggcgcc ttctactacc gggtgtccct gccggcgcac aactacgaga tcgtcgagct
     6001 ggagagccag acgctcttcc ctgccgccct tcccgactgc cgcctggtca tcctgaactg
     6061 gatccagcgc gacgactccg atggtgacac cggttccgca acgcggcccg cggtcgagga
     6121 agcgcgctcg cagccctcgg ccagcccgct gcccggccaa gtcacggccg gcacggcgga
     6181 cgaggccgcg aaatacgctg gcccgggcgc cgttgcgctg ccgatcctga gcgagctgat
     6241 cggcaccggc tgccagctga cctattcccc caccaaccgc accgtcatct gggccacccc
     6301 ccagcacgac ggccggtggg atgtcgccga ggtgaacccc tacacggtgg ttgtccgtat
     6361 gccgcaggcc atccacgtcg agggcgcgac ggcggagtac aaactgctca cccgcgccgt
     6421 gctgccagcc gagcccgccg acgccgtcca gcggatccgc gagatgacgg cccagctgcg
     6481 acgacgcatc gggatcctcg aagagattca ccgcgacgag ttggaagccg accgcagcct
     6541 gccgtacggg tggaaccccg tcgacgacga ctgacccaca ccgcacggat cgttaggacc
     6601 tccgaggcga tttgagccct cgtgctcgct gcgaagcgcc ggccagcacg agggaatcga
     6661 ggccgctgaa ctgcggaacc agatcaggtc atggtggcgg gctcaccagt cgcgggtggt
     6721 ctcgtcatcg ggcgatggcg agaccgggta gagcgagcag gccacccctc tcggcccgca
     6781 cgtccgtcac cttcaaggca tcgggtgacc gggctccccg tagaagcaac tcctcgacga
     6841 ccatcttggc ggccctggcc gctccgtccg cgccgtcgtc ctcgaagtcc cgctgccacc
     6901 agcccatgat gcgctggcgc catccccttg cccgcatcac gtcctcgggg gtaccacccg
     6961 gcacggcgcg gtcgtcaacc agcagcacca agcccccggg ctcctcgcac atcaccgaga
     7021 cccgctcgac ggagtgctga tcttcgccgc gaaaatcgat gttgaaaccg accgcatctc
     7081 cgtacccaag ctgcaccggg acctgctccc accagccact gagcaactgg gccagcgaac
     7141 cctccagcca cgaccaatcg ggagcaggcg gtacggccgg aaacccaaga ggcgggctcc
     7201 ccacgccacc gccatacagc tgccacacgt aaggcagtcc tgtgtaaaac cccaccgggt
     7261 ccgattgctg gcaaggggca aatctcgcgc gttcctcggc ctccaactcc gacgtacgcc
     7321 gcacgcagag ccgtagcgcc tgctgcccgt ggtcgagtag gagcgtccgt tgatcgtcgc
     7381 gccaccgcac tactggaccg gtggcatcgc ccccgcatag cgtcggcggg ccgatccgtt
     7441 tgatcgcgcc atcgaggact tcacgggtca tgctccttcg gcgcgtgacc ggaactccac
     7501 cgctgtactc gtagagagtt acgggtgctg cctgaaagtc accattcgta gggtgatcgt
     7561 gcaggtgcac ggccaggtcg cctatgccgc ctccaggacc catttcgtcc atatgtgtaa
     7621 ttttgagtgc gggaagcgat ccggcaacac gaacgaagga cgcgtagctg ggcaggcggg
     7681 cgaaggcttc cggaggggat tggccgcgga ctcctggggc agccgtcata gccggccaat
     7741 cacgactgcc gagtttgagg ccggtggtgg cgaggtccgc tgcctacctg gccgtcagcg
     7801 cacccctaat cccggccccg gaagcgcggc agggatggtg agtccgcagg acgactcgga
     7861 ggcgaccttc cggagtcagt ggcagcagcc ggtgagcact ccacccccgc agcggcgact
     7921 tgaggcaact accggcgagc atgtgatgct catctagccc tcctcgtttc cggtccctgt
     7981 tccaaggtct cagccagatg gtgccccgtc tcgcagcgtg gggtggggga gggggttctc
     8041 cgctagcctt gctggcgctt gcttggtgcg gctggagcga agccagggag agggaaacgt
     8101 cgtggtgaag gtcctaatcg ccgggggagc cggctacatc ggcagcactg ttgcctcggc
     8161 ctgcctggat gcgggcatca cccccgtgat cctcgacaat ctcgtccagg gccgccgcga
     8221 gttcaccgag ggccgcacct tctacgaggg cgatatcgcg gacggcgcac tggtcgaccg
     8281 gatcttcgcg gagcacccgg agatctccgc cgtggtgcac tgcgctgccc tgatcgtcgt
     8341 gcccgagtcc gtcgctgacc cgatcggcta ctacgaggca aacgtggcca agagcctggc
     8401 cttcgtccgc cacctgcatc gcaacggctg cgatcgcatc atcttcagca gctccgcctc
     8461 cgtctaccag gccgaggacg gcacgcccgt gaacgaggac tcgccgctgg cgccgcagag
     8521 tccctacgcg cgaaccaagg ctgtgtgcga ggagatgttc gccgacatcg ccgtggcggg
     8581 gccgcgcgtg ctgtcactgc gctacttcaa cccggtcggg gccgacccga agctgcgcac
     8641 cggtctccag ctcaagcggc ccagtcatgc cctgggtgtg ctcatccagg cacatcagga
     8701 aagccgtccg ttcccgatta cggggacgaa ctacccgacg cgcgacggca gcggtatccg
     8761 ggactacgtg cacgtctggg atctcgccgc ggcccacatc gcggcgatcg agcgcttcga
     8821 ctccatcctc acgggggcga agcgctcgat cgcgatcaat ctcggcaccg gctccggcac
     8881 cacggtccgg gagctgtgcg aggcgttcaa caacgtcgtc agcaccccct tggtcaccat
     8941 cgacgccgat ccgcggcccg gtgacgtggc cggtggctac accaagagcg atcgggcggc
     9001 cgagctgctg gggtggacgc ctaagctgtc cctggaggat ggcattcgct ccgccctgga
     9061 ctggattccg gtgcgcgaca agttgttgaa ggactgatcg gtccctggcc ttcgcttcca
     9121 gggtgctgat gccccgaacg cgatgcgagg ggctccgcgg agggcctgcg catggcggcg
     9181 cgggtttgac cgtacgtcct actcgtcgag cctcgcggtg ctgtcagcga cgtgcacgag
     9241 ttgcgggtcg ggcgggccgg tgcccgcacc gcagggtctt atgtcggcac agcttcaggg
     9301 ctgcacgaga gagtggcctg tgaactcttc ggcgagggtg tccatgatcc gctcatcgca
     9361 gacctgtccg agccagtagc cggcgttgcg gaggagccct gcatcacgga agcccgcccg
     9421 ttcgtaggcg cggatggctg gtgtgttggg ggcgagcact ttcaaccaga ccatgcgcag
     9481 gttggtgatg tggaaggcgt agtcgagggt gagtcgggtg gcctgggtac ccaggccgcg
     9541 cccgcgggcc tgggggtcga tcatgacgat gtattcggcg gtgcggacgg cgtggtcggg
     9601 caggagggtg gctacgccgg cgggcacggg tttgcccgag gtgcggtcgt agatggtgaa
     9661 gcggatgttc tcgccgcgga gctggtggtt catgccttcg gttcgtgctt ccagggactc
     9721 gggggattgg cgtccgtagc cgacgagcag ggcggggtct tgttcccagc gccagtacgt
     9781 ttcgacgagg tcggcgcggt aggggccgag cgcgcaggtg tcggtggcga gccacaagat
     9841 ggggtcaggg ccggagctga tggtggcctc caatggtgtg tgccggggtg taggcgtacg
     9901 tcgagggcgg ctcttcgacg ggggtgccgt ccgtagtcag gggcattgcg atggttcgag
     9961 gctgcccctg cttcgtaacg ccgcagaact gtcagcgtgc ctaactgcgt tctagcgggg
    10021 tgaacacggc ttgtcgggcg gaccatgcca aggcgctctg ggttcggtgg gatagaccga
    10081 ttcggttcca atggaagatg acgtggaggg cgaggacgtg tcggaggccg cgttcgagtc
    10141 gtgcggcatg ggctgcggcg ccgagcgctg cgcctgtgtc gcggaaggct gatacccagg
    10201 tggcgactgg gcggaggggt ccgtcggcgg ccaggtttgg gcccgccggg gcggtgctgg
    10261 cctggagcag ggtgcggagc tgctggacca gttgcaggcg gcgttcttcg gggatttgct
    10321 cggctgcgga acggccctcg tcgctgatga cgcggtccca gacatcgccg gcttcgtacc
    10381 attccaggcc agcgccccgc atcatggccg agcacaggag aacggagagc tcgcggcggc
    10441 cgagggcgcc gtctgggcga tcgggcaagc ggagaatttc gcggctgtcg acgacgaaca
    10501 gttcgtgggc ggtatcgata ccgagggcgc cgccgaaggc cgcggtctcc ggttcgtaga
    10561 tgccgggcca ccatcgcttc acgtgatggt gctcccgtag ccggtcgagt gccgcgctga
    10621 cgtcggctac ggcggtggag tcggggcgag ggtggaggcg caggcgccag caggggtgtt
    10681 tgcggatgaa ccaccagccg gtgagggtgc cggcttcttg agcctggctc agtacgggtt
    10741 ccagaagggt ggctgcggtg gattcggcgg cggaccagtc tgggaactcg atgaaaatct
    10801 gctgccaacc gagggtgctg gtctggtgtg cgagggcatc gtgtccagcc tgttggaaca
    10861 gctcgacggc gtccgccagg tgtgccggat gcatgtgcgc ccgtcgggca atttcgtcca
    10921 gggggtggcc ggccaagacg tcgaggacgg cgcggtcgat gggggtcagt cgatcaacag
    10981 gcatgcgtcc catcccgtct gagtgatcgg agcgcccgtg gtcagcgagg acagggcgag
    11041 ggcgcatccg gcgttgcccg tcagtagtcc cgcgttgtgg tcggctgttg tgcggaggtg
    11101 agtggtgagg gtttcgccca agcggggcag cagctgacgc aggtgggggt aggggctgtc
    11161 gtgggcggcg cgggccgtgg tttggtagac gccggcccag ccgtggcaga gcgaggtgtc
    11221 gcggatgagg gcgagttgct ccgggtcggt cagggacagg tagagcgcga cctcgtacat
    11281 gtgctggagc ccgcggtcgc ccagggcgat gccggcgagt tggccggcgc gtgcgatgcc
    11341 gggggtgccg tagcaccagc tcgggcggcc ggctccacgt tgatgtgtcc gaccggacga
    11401 gaactcgtcc agggtgaggt gcagtggcca ccaggggccg cgttccccgt cctgtcgcca
    11461 ggcatcgagg tgggagcaga tggcgtcaat ggcctcgtgc tgcccgtcga cgctgacgcc
    11521 gcgacgcagg gcttgggcga ggagcagcag ggggccggtg atgccgtgtg ccaccccgag
    11581 attcgcgtgg ccttgggcga attccgcgct ggtgccgcgg ttggggtcgt gtgcgaccca
    11641 ccagccgggc agccggtggc cgttgatggc cacggggtgg gtgagggcga cgaggtagcg
    11701 caggacctgt tccagtgcgc tgctggtggg gtctgcacgc aggaggtagg cgccgatgcc
    11761 ggtcaggccg cagaagaggt cgtactcggc gaaggtggtc agctcgccgc ggtgtatccg
    11821 ggcgagtgct ctttcggtgc gttggtgggc cagggtggtg acgtggtggt ggagtttctc
    11881 ccacgcagtg cggtagagct cgtggaagcg gccgtgaggc acggtgttga gcaggacgaa
    11941 ggcgagggcg gggacaccgc ggaacaggcc ggcggtgtcg gtggcgtcga gttcgccggc
    12001 ggcggcatgg ttgatccagc ggtgcgccag cttccagggc ccggttcggg cctgggcgcg
    12061 ctcgatgtgc agcagcgcga tcccggctgc tccgtcggcc agcgactgcc cttcgaaatt
    12121 ctgaccgggg cgtgggccgg agagaacggt ggcgcatctg ctggctatgt gtgcggcttg
    12181 ggctttggtg gtcatgtggt tctccgggcg gtgtggctga gggctgaggt gcgcgccagg
    12241 cggagggtga gggcttcggc cttcgggtcg gggccgaggg cgcggatgtg gtgggcgtgg
    12301 agcagggagc gcagcacggt gagcgggtcg cgttgtccga ccagggtgct gcggtaggca
    12361 gccagggctg cggcgcgggc ctcccacgcc acggtcaccg acgtgccgtg tgccgtcgtc
    12421 gtgaacggga aggtcgcgcc gggttgggtg gcggtcaggg tctgttcgcg aagggcgcgg
    12481 tccaacgggc cgtgctcttg cgggagatgc gtgatgagcc agtgcaggcc cgtgtcggtg
    12541 gtgggggcga gatgggtggc gaggttgagc aggctggcgg ccgtgagcgc ctccggcgcg
    12601 agcgcgtcgt catgggcgac gtagcggatc tgggccaggg ctgcggcgga gtcggcggcg
    12661 aagacgccgt ggacggcgtc cagagctggg ccgtgcccga aacggcccgt ctgcggggtg
    12721 tagctggaca aggtgagatc ggcgatcaag ccggcacggt gcagggcagt agcccaggcg
    12781 tgcacgaggt cggccgccga gccgtaggtt ccctcgggca ggtgcaggac aaggacgagg
    12841 tgccggccgg cttcggggcg ggaggcttca cggtgtcgta ggaaccacca ccgcggcggt
    12901 tgatcgaagc gcgccaggag agcgggcagg tggcgatcga ggatctcgtc gtgccgctgc
    12961 ggatggctgt gaaggtgcgc gcggagcacc actccggcgc cgggaaactg ggcattggcc
    13021 ccgtcgaccg gatgctgggg tgctgggagc gggaggcttt gctgcggctg ggtgcgacgt
    13081 agggggagca ggatctcgtg ggcacggccg atccacccgt gtcggtccgg ctcaggggcc
    13141 tcgcgcagtt cgagacgctt ggcctcgtcg aggcgggacc gcagcaagta gcgatggacg
    13201 ggatgcgtca ggtccagagg aagacgctgc tccagctcga ccagcgcaac ccgagcaggc
    13261 acgcgcatac ggcgacgcca ggcagtcaac gcttcttccc attgcggcat cttggccgtg
    13321 cgggcgggaa gatcggttgc ggtgaggagc cagcgggccg gtgccaggac ggttcggcgg
    13381 taccggaccc gtggcaggta gggcagccgg ctggctgcgc cgaaggagaa cgggcagtac
    13441 acggcgcagc ggacggtgga gacttcggcg aggaaccgcg ccagcggggg cgtttggatg
    13501 ccggcttcca gcacgtgggg gatgtgcagt tccacccgcc ggccggcgga gcgctgtacc
    13561 aggtgcaggt ggcgggcatc ggcagtgacg gcgaggtccg cgagggtgat cacctccttg
    13621 tcgccgtccg ggcggtgctc ggccagcggg aggacgggca gcaactgcac ggtgcgggag
    13681 atgttggcgt tgcggtgccg gcgcggggtg aagctgagct gcgcggtcac cgtctcctcc
    13741 gaggaaggac ggtaggtgcg cgcgagggct tcgcggtcct cctggggcag gaggcaggcg
    13801 aatcggccag ccatgctgtt ggtgggccgg gggacgctgg tgacccacac ctcgaacctg
    13861 ccgcgggcca gctcccgggt gctggccgcg tggacttcga aggccacttc cagccgggga
    13921 gcgaactccg gctcctcgga gccggtgacg cgggccaact catcgatgtc cgcgtccgtc
    13981 agcaccagct cctcgcgccc gtccatgagg acctgctgaa ggcgcgccag cagcttctcg
    14041 tcgcggttcg tccacggctg gaccgacttc tcacgctcgg ctccgacgta ggtggccggc
    14101 aggcccagcc cgtgatcgcc gaccaggtcc aagaccggca cggatgcgcc gacaccgtag
    14161 cgagcacgga aacgccggtg gtagtcgcgc catgccgtgt gcccgtaggg gtgcggggtg
    14221 gcccggtaca gcgcggccac cgcgctttga acttcggaca cgacggagtg ggggatctgc
    14281 acgtggccgt ccaccgtcgt gtcgacgagg aggggcgccg gagcgatgac ctggtcgcag
    14341 agggcgtgca tccgctcggc cacatcaacc agcacgccgc tggagggcgc ttcgatgctg
    14401 acggtggcgt ggatgccgtc cagctcgcgc accagagggc caacgccggg gagggcgtgc
    14461 gcaccgatcc gcttcagctc ggcacagaca tgggccaggg catcaacggt ggtcatcggg
    14521 gcccacaggc tggagaccag caggtgctgc gcgatgagat caccgagcag accatcgacc
    14581 tgcccggcgc aggcgttggg gaactgggcg cgcatctggt cgcgcagttc cctgtaggac
    14641 aggggcacgg cggcagcggt caaggcggcg aggacggtgc gccgcgcggg aacggacacc
    14701 tccacgggtg ccatcagcac cgcgcggccg tcagcgggcg ggcccgcggc cacaacccga
    14761 tctccgcgta cgactgcggt ctcgttcgcc acgaccgaga gccgctccac cacggctatg
    14821 tgacagtgca gttggcggat cacctcagcc agccaggcgg catcggcacg ggccgtggcg
    14881 cgcggcgacc cgtgccaccg caccagcgca gccgggccta ccgtcagggg ggcaatgccg
    14941 gcgaacaggc cgaacggggt ggcgcggtgc tgccaccgca gcaggtagga agcaaccgac
    15001 aacacggtcc gctggatctg ccgtggccgc ttctgcaccc cacccacgat gctctcgact
    15061 gcccggcaca acacgggagt agccacctgc aaagcacccc gcacgtcagc gtcctgccag
    15121 acactgccca gccacgcacg ggcaacggcc gagtccccca ggccgcgcgg gaggctgacg
    15181 acgccggggc gtgtggtggc gcgcaacatg gcgccgccgc cgtactcata ggtcacagga
    15241 gggaaagcgg gcacgcaggc tccttcgacg gtaggcaggc atgaccagaa gtgctggtgt
    15301 gccgggctga tgagcccggc acaccagcga ggagccgatc aggccgggtc ctccgtgaac
    15361 gacgtgcagg ccgaagcccc gttggcgcac gtgtttccgc acccgtcgtt ggtggcgcag
    15421 agcaacttgc cgtgcgggtg ggcggcgacg acgaccttca cgtccaacgg cgcaaagtcc
    15481 tcctcaccgt cgacctccat cggatcgagc agcgcggtgt gaatcatgaa tcctcccctt
    15541 cagtgatgga gtggtgcatg acgacctggc cctgcgatta gtgagtgggc caggagagcg
    15601 agatcctgca gtgcaccttg tcgatgaccc ggtcaccgtg gacctggtca tcgctggtgt
    15661 tggccggata gacccggatg accgggctgg ggccgccgcg gcggctggct tcccaagtac
    15721 gcagctgctg cgccatctcc tcggcgagtt gctgtgcgtg ggcccccagg gcgtggacgc
    15781 cgaactcgga gttctcgccg tccgcggtgc ggcggtagat gacgtagccg aagctgtcgt
    15841 tctccacggc agccagggag aagccggggt tggtcggggc gacgatgccg gagtcgagct
    15901 ccttgtccag caccatgatg cagaagcccg gcagcccgat ggccaggtgc atctgaagtg
    15961 tgtccagcag ttccccacgc ccgatggtga cgccagtcca cagctcgacc cgcggcgtgg
    16021 tgaccgcgtt gtcgagctgg ctgggctcga tcgggatgcc gtcgtcgaac cgcaggccga
    16081 tctcggggct gctagcgacc aggagcagct tcacctcgtg ggcggtggcg ccctgcatcg
    16141 gcacgaagcc gcagatcttc gccgactcgc tctccaggtg cccaccgcgg cggacgaagg
    16201 cgacggaccg ggttagtccc cgcatccgca ggggaacaac cagccggcct tcgggagcga
    16261 gctgatcgag ccaggccaca gggacgtccc aggccccagc ggtgaccatg atgacgtcga
    16321 cctctcccag tccggggatc ggctcggcgg catcggcggt gacgacgcgg acgctcttgt
    16381 acccctgctc gtccagcagg cgccggcccc gctcggtgac ctcggggtcg atgtcaaccg
    16441 tcgtgacctc gccgccatca cccaccaact cggccatgta ggcggcgttc aggccaccgg
    16501 agccgacctc caacacccgc atgcccggct gcagtttggc ttgttccagc atcatggcct
    16561 ggatctgcgg agcggagacg ctgctgatct gcacgccgta ctcgtcggtc ttcgtgacga
    16621 ctgccgcgta gggctcgtag accttttcga ggggtgcctc aggagcgaag gcgtgacgcg
    16681 ggaccttgcg catcgctgcc tcgacctccg gcgtgacgag cacgccgtcc gctcgtagct
    16741 ggtccatcac ggtgttgcgc agtgtcgtgg cctgctcggt atcgacggtc atgacgatcc
    16801 ttcgtagtgc gtttctggaa agccggcagg caccggaaca gtgcagaagc cggctgcgga
    16861 cgacgctatt gattcggaca ccgcgttgtg cggtgctcac cgacagtggc tgagatgcgg
    16921 ccatcgagca gaggcagatc tccttcacgt ttacgcatgt cggtgatgtg gtgagaggcc
    16981 gaaccgatcc ccactttccg gcgccgagcc ttgtgccagg accggcggcg ggaggtgcgc
    17041 ccgaacccgg tgtgggtccg gggtggagca gaaccggtgg agtgagaccg ctagctgtcc
    17101 gggttcagcg ggcacggctt gtcgcagtac ttcttacaga tgtgggtctg ccgggagtgt
    17161 cgggtgccga gtacttcttg ccgttgggct ttgcctcggc cgttgttgtc cctgtcacca
    17221 gcggccttcg ccacccggat ggtgtccctg cctttgcctt tgcccacgat gtcctttcga
    17281 agtggtagtt ccgcattggg gtgaagcccg cacgcagcct gtgaattgct ggggcgcctc
    17341 ggtggggttc agacgccggc gggcttcgcc gcatagtggg cgaggaaggc ggtctgcata
    17401 gcctcggtga agcgctgggc gcacgggttg ccttccgctt cctgtgcacg atcggcgccg
    17461 aagtgcttcc agtagcgccg gccgctctct cgctccatga tcttgttagc cacgaagcgc
    17521 agtcgcctgc cgcggagcag gcccagtcgg tgccggagcg agagcacgac catctgttgg
    17581 ttctcgctca gcagctgcgc gaactgccca ctgtccatcc ccttgggcgc ccagtcctgg
    17641 gcgaggtccg ggttggcgac cagctgggcg atgcggctgt ggtggagctg ggccaccgcc
    17701 acttgactgc gctggttttg gtgccgttct cgctgtgcga cgtggaccgc cccgacggcg
    17761 gcgaggacaa ggagagcatg cgaggtcttc atagagattc cttccatcac ggtgtggtcc
    17821 ggtgcgaggc aggacgagcg ccacgaggcg gctcgcccga tggctgaagc cgaggcggag
    17881 cccgtggtcc ggtcaaatcg cagcgacggg ttggagggag aagatcaagt gtcacagtgg
    17941 tgaccgacta cttctgtcct ccgtcaggtg agcggcacgg ctttgagctg gtcggcgagc
    18001 tgaagggcgc tggggcggct gccgggcggc tgcgccatcg cggcggtgag cggtgcgagg
    18061 aactccggcc agggatggcc agcggccttg gccaggggga tcttggctgt ggcgatggct
    18121 cgacgcaggg cgagcgcgct catggtgctg gagtcgaggc cggcgtcggc gtaggcgagg
    18181 ggccaggtgg tggtggcggc ccaccacagg ccggcggcca gggtgtagat ctcgtcgtcg
    18241 gggtcgagca tcacgctggc tgccgtgggc tccagcgcgg cggcgagtcg cggggagagc
    18301 aggtgcacca ggccgccgag gtaggtggcg gagacggcgt tgccgatccg cgaggcgccg
    18361 gtgcaggaca gcagccggac gcctgcggtg gtgtggaccg cgtggtgggg gcgaaggtcg
    18421 ccgtggaccc agccggcagt gtggagacgc cccacggcca tgcacaactc gaccgcagcg
    18481 caacgtgctt cggcgcgccc tccttccgtg gtgtcgcgca gcttcttgca cgcgtcccac
    18541 gtggtggggc cgtcggccca gggggtgacc agccaggccc agggcgcggg gcaggagacg
    18601 ttgtcagcgg tgtgcaggac gcggattcct cccggcggca tggtccggag ggcggcggct
    18661 tcgcgcacca gggcgcgggc ggcgttttcg ccgctggcga ccttcacggc gacggtcatg
    18721 cgtgggccat ggacctgcca gagctggtga tcgtggcggt cgcggatcag ggcccaggtt
    18781 gcgggggaac cagcgcattg gctggcgtag tcgctggcgg tgtcagggca acgaagggac
    18841 ggtgtggttg aggtggtcat ggggctccgt aatgaaacat gtcgagaggg ctgaggtcgg
    18901 ctggctggtc agaggggaat cgattcgatc cagtcggcga gttgatgggc tgtgggccgg
    18961 cggctcaggg agggggacat cgccccggcc agcggttcca ggaactccgg ccagtcgtgc
    19021 acggcgggat cggcgcgagg gacttctcca ctcgcgatga tgcgtaagag gtgaggacgg
    19081 ctcttcgtct gcggatcgaa tccgacgccg cggaagtcgt cgtaggccag cggccacgta
    19141 ccggtgaccg cccaccacag cccagcagcc agggtgtaga cctccgccgg tctgctcagg
    19201 agcagtccgt tgccgcggga ccggtcgatc gcgttggcca gttcaggcga gagcagatgc
    19261 accaggccgc cgccatagcc ggggctggtc cgtctgccag cgcgggttgc ccaggcgcag
    19321 gacagcagcc ggactcggct tcgctcacgg gtgtgaacga cgtggtgcgg gtcgagtgtg
    19381 ccgtgcagcc agccggccgt gtgcaggcgg ccgacggccc ggcacgtctc gatggcgacc
    19441 gcccgagcct gttcgcggcc ttcttggtcc ccttcgcgta agaggcggaa tgcctcccag
    19501 gtcgtcaggc cgagcgccca cggggttatc tgccaggcga tcggatccgt cgggcgcagg
    19561 tcggaaccgg ctcccaggga ccggaggttc ccggcgggca tggcgcgcag attctcggtt
    19621 tcccgtacca aggtcagggc tgccctctcg cctgcggcga ccttgaccgc tacagacgac
    19681 tgcgggccgc ctacctgcca caggtgggtg ctgggctcgc tacggcacag tcgccagatc
    19741 gcaggggagc cggcaagccg gtttgcgagg atggtggcgg cgaacggagt tcgcaggctc
    19801 gctttgagac cggaggcgat gctgctggtc acgtgaagac ctccgcctct tcgtcacgga
    19861 gcaggcacag agcacggtcc agagcctcga tgagccggcc gaggccctgc gcccggacca
    19921 cggcctgtgg gagggcgagg ggcggcggaa gcgggaggcg ccggtcggct tcgcggagcg
    19981 tggcacgcac acgggcaagc tcgggctcct ggatgctgca cctgccgagt agggctcgca
    20041 gacaggctga ccggtcgcgt ccgtgcacgg tgagccggcc gatcgcctcc cgaacagtct
    20101 ccccatccgg gacttcagag ccccgcggcg tccaggcggc cgccacagtg atgagcgaga
    20161 ggacctcgtc cccatcagca gcaggacgaa tcagtacagc catgcggtca cctgccccgc
    20221 agtcaggagc tgcagctccc acaaccgctt gacggcgtgg acgcgatttt tagcccgaag
    20281 gttggtcagg aggtcgcggt tgtcccttcg gatgatgtcg actggccgct tcagttcggc
    20341 ggccatgcac gacgccgtca tgccgcgggc gaggagcggc acgatgtcct gctggttatc
    20401 gggcaggagc agggtttcgg ggtccagcag tgagggtcgg gagatggcct tggtggtgta
    20461 gccgacggcg agcgcggcgg cgctctcgcg cacgccgtac aacttccgct tggcgccctt
    20521 gagatagccc gaagctgtgc cctcccggat cgagaggcgc agtgcgaccg cggcgagcat
    20581 gctgccgtcg gcgaggccct caagggcttg ccgctccctg ggcgcgaggg tgacccttgc
    20641 tggggtcgtg gttctcatgc cgcttccgcc atggcctggt gccgcaccgg ggcgatgtcc
    20701 tgcccgtcag gcagcagatc accggtgtcg aagggcagga cgctgttgcg cagcaggccc
    20761 cttctctgca ctttcctcat ggccgtacct tcacgtcggc cacgaccggc aggtggtccg
    20821 atgccttacg tgcctggggt gtgtcatgag tgcggtacga cgtcacggtc atgccatgga
    20881 ctagggcgta gtccaggcac cactccaccg gctcgtcggg gtaggcatat ccgacggtgg
    20941 gagctcgctg cacacccgtg agtgtctgcg ggtcctgcca gccagagttg agcagcagct
    21001 ggagcgcgtc ttgatccaca tcgccaaacg agccgtcttc gcggatcttt cggtatcggg
    21061 agtgcatgtt ccgcgggatg agcgaccagt cggagttggg cggttcccgg tcggggacgt
    21121 tcagatccgc cagcaggatg cctcggggcg gcatgccggg aaacttgccg ccgtagtcgg
    21181 tcatccagct ggcctcgtcc agccgcgtct taccgttcct ccaactgagg tgggtggcga
    21241 ggacgaggaa gtcgcgccgg tcgtcggact cttcgacagg gcgcagccgg gctctgatca
    21301 gagcgtggtg gaatacatcc cttcccagga ctgccctgtc caggagccgc aacgtggacg
    21361 gccggtacag caacgcggtg tggttctgga cggggggtgt gcccagtcga gatcggatca
    21421 tggccacggg ctggaggccc agggtgtccg ccatccagca cagtcgtctc tcaccgtcct
    21481 cgtcccatcg gttacattcc ggcaggcaca cgatgtcggc gttgagcctg agcaggatct
    21541 tcgcctgctt ctggaggcgt tcctctgagg cgccatctac gccccccaag tacaaattcc
    21601 agataacggc tcgcatcacg cgccgtccct cctgcggtgg atgagcgttc cgcgcagagg
    21661 gttggtgcag ttagcacgcc ggccctgctc agggtggtgg accttggact gcgcggcctg
    21721 cctgtcggcc gcatcagccg tgggacacgg tggggtgtgc gcgcacatag tgttcgtcct
    21781 ctcggtgcgg gcgggaagtt gggccctctt cggcgggcta cgaggccgtg ggggaatacg
    21841 gttcgaaggt ggccgaagag ggtgtctgtg ggtgtttctg tatgaacgcg gcgattgctt
    21901 cctcgcggta gccgtagaag tgacccgcga ccgcgtcggc cacccaccaa tcgggagcag
    21961 gatcgcccca ctcgacggtg tggcaggtgt cgcggtacgg cgaccagcgg acacggagcc
    22021 gcggaaagcc cggccggtcc ttgagcagac tgcgggctgc catcgccagc gacagcagat
    22081 cgaaggacag gtacccgcca cggcgggagc ctccgaccgg tacggcgagc agcggcgctc
    22141 gaaagacgcg gacagccacg gcatgggcaa ggatctcggg ctcggcgagg cgttcgcgga
    22201 agtagtcgaa gtcataggct tccgcagcag ggcggaggga gaccgtgaag ggactcgccg
    22261 tcgatgtggt tgtgatcagc attcgaccag ccccttggcg atgccggtgt cttccaggcg
    22321 ttcggcgaga cccagcgtga cccgcgctag cttccgcagg agcacgacgg cctgccatgc
    22381 gtcggcgggc agctcctccg ggatcagccc ttgcgcctgc tcgatcagga ccgcgatgtc
    22441 ccggtgcttt ctgtgggcgc cgtttcgaag acctctggtc acgagctgaa tgagagccgg
    22501 ccggaagcgc tccgccagcc cttcaagggc gtcgtactca ggcagaggag acccgaccga
    22561 ggtacccgcg gcgtggtgac tgacttcgtc gcccaggacc gtgtccaggt cgtcatagac
    22621 ctcgtcccag tccaccggtt cccatgtgcg cagtctggac agcacccgac gaacgtcctg
    22681 cacgtcgggc ggtgagatgc aggggttcgt cgggaccgac gggtccttga cccgtaccgg
    22741 cgccgacccg ggccgctcat cccagtgaac agtggtgctc gccatcagca cgccgccaaa
    22801 ctcagctcgc accatgtgct ggcgccgttg tcgctgacac cccaagcacc ctgtctgttc
    22861 cgcgcgatct cctgtacgag cagcaggccg cgaccgtgtt cgtcgtcccc ggggcactga
    22921 gcagagaggc gaggtcccgg cacgccgtca tggacacgga tgcacaggac gtcatcgcac
    22981 acgtcaaggg tcagccggat ctgcctgcca ccgctgtgca cgatggcgtt agtgatcaac
    23041 tcagagacaa cgagtgtcgt gtcgtcgacg acgcaggtca gaccgcggga ggtgagacgt
    23101 tcgcgggtca cgagcctcat ggcgctgacg cgggactcgt cttcgggagg ggggcgctca
    23161 cccggggagc gcttggtgat ggagaagcgc tcctccacca agccgccggt acgagccgcg
    23221 gtcgggcgcc gtggcgccga gccgatcacc gctccgtccc gatccgcgag gccccgtctt
    23281 ccggggcggc ccggtcgttg agggaagcga gagggcccct cgggcgccgc tggcccggta
    23341 cgtgtagaag cagcgcggca aaagcgggca acggagtgtt cgaggcgtcc gctaggttgc
    23401 ggcgtcgctc gcgatcggcg ggagttcggg cggtcatcgg tcgtcccctt ccgcgaaggg
    23461 gaagagggca ccgagcctgc tgtgcagagc aaccgcttca tcggccgtca ggaccagcgg
    23521 aatggtcgcg ggctccgcgg ccccctcgtg caggtcgagg gggaccgcga aacgaccggc
    23581 ctccgtgtgc gcgacctcgg cctcgcaagc aaggcggagg tggcgcttgg cgggcggtaa
    23641 ggacgccgcg ccggctcccg tctgagcgtg acttgtcgtc atgacccgta aaagtagggc
    23701 cacttcgaag ccccatccct gagaaaaaat cagggctgag taacgctcag ggttggcata
    23761 tgcctatgcg gcgagcccga tgtgcttcgc taccgcacgc aggtcgtcgc gccacatcgg
    23821 cttctcgcgc tttagcaggt cggctaccgc ctccctgacc agggagagaa cacgatctcc
    23881 tccggagact gtttcagcag cttgccgaga atgtgcaccg tcgcgtagtc gtctcgctgg
    23941 atgcggttga ggttcattac ctcaatcagg taccgggtcc gacgttcgag cgggacctct
    24001 tcgttgacaa gaacgtgatc ggcggcgcgg agtgcttcgc cggtgtcgcc ttcctccgcc
    24061 ttcaggtgta cctcgtgcat ggcgaagttg gtcggcccga agcacgtgtg ccagtggttg
    24121 aggtctgcgc cgacccgggc cacggcctgc tgtgccccgt ggtacaggtc ccacgccctc
    24181 gggccctttg cagcgcgtac ggcagcgacg gcaccttgca agtgcagtgc gccgtacgcg
    24241 gaccagtgcc ccgggttgga gtcgtcgtgc ggccggcact gggcgatggt ctgctgggcg
    24301 agttcgtagc tgtcttccac atctccagcg gaagtgagaa cgcaggccag gttccaggcc
    24361 gcagccgcga ggagggccgg gtcaccggcg ttgtccgcga gggagaggcc gcggtcggcc
    24421 gcaattcggg cgagggtcgg ttcaccgacg cgacgaagcc agatctggtg caggccgtag
    24481 aggctgatga gctgccggag gaccgtgccc tcctgctcag gcgaggcgtc gcgcagagcg
    24541 gcgtgtcctt gccgcaacag ggtaggcagc cgctcgccga cgtcgcggta ccggtcatca
    24601 gcctgcgtct cgtagacctt ccaagcgtcc gtaaccgacg actcgaagtc atcggaggcg
    24661 accgacccga tgcgctgcgg aaggagggag gcgggcagcg aaagggcctg tcggatgagc
    24721 ggcacgtgct cgtgctccgt ccccgccgta acgatctcgg acacgtagcc gcccgtcagg
    24781 tcctccagac tgcatcgcag ctgcttactc agggcgatca ggatcggaag ccggtccagc
    24841 ggcatccggt cgttctcaat cttgtagacc cagttctctg acctgccgat taggtctccc
    24901 agcatccttt gggacaagcc ccggcgctcc cgccaccact tgatccgttg gccgatgctg
    24961 aacaactctc cgtcatacac catgggttga ccgttcgccg tagtggacag ggcactcgtg
    25021 tcaagcgtag gcccacgtgc ttcacggagg ggcgatactg gaggtctctc cctctgggga
    25081 gggcactcaa cggtccccct gtcgccctgc ggccggggga ccgcgtacac gcatgaaaga
    25141 tcggcaagga ggccgctttg ccagccccat accgtggcct gatcctcgac ttcggtggtg
    25201 tgctcacca
//
