LOCUS       NZ_CP104098            25433 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces noursei strain IFO14147 chromosome, complete genome.
ACCESSION   NZ_CP104098
VERSION     NZ_CP104098.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9223378)
  AUTHORS   Zeng,X.
  TITLE     Transcriptome and Metabolome Analysis Revealing the Improved
            epsilon-Poly-l-Lysine Production Induced by a Microbial Call from
            Botrytis cinerea
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9223378)
  AUTHORS   Zeng,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2022) College of life science, Huaibei Normal
            University, Dongshan road 100#, Huaibei, Anhui 235000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: PGCGAP v. 1.0.34
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025163575.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 12:09:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,195
            CDSs (total)                      :: 8,101
            Genes (coding)                    :: 7,883
            CDSs (with protein)               :: 7,883
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 218
            CDSs (without protein)            :: 218
            Pseudo Genes (ambiguous residues) :: 0 of 218
            Pseudo Genes (frameshifted)       :: 93 of 218
            Pseudo Genes (incomplete)         :: 149 of 218
            Pseudo Genes (internal stop)      :: 11 of 218
            Pseudo Genes (multiple problems)  :: 33 of 218
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:04:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 525688
            Orig. end                         :: 551121
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP104098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25433
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="6"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25433
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25433
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15433](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15433)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    155..171
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.6"
                     /tool="antismash"
     misc_feature    159..177
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.28"
                     /tool="antismash"
     misc_feature    complement(163..181)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.56"
                     /tool="antismash"
     gene            195..797
                     /locus_tag="N1H47_RS02590"
                     /old_locus_tag="N1H47_02590"
     CDS             195..797
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577777.1"
                     /locus_tag="N1H47_RS02590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02590"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_016577777.1"
                     /transl_table=11
                     /translation="MPKQVDHRERRETIARALWRVVEERGIAQASVREVAQEAGLSHGA
                     VQHYFATREEMVVFAMDFASAQTSLRVAEGVSGLGDPPHPRDLLRVMLVEMLPLRPDAR
                     TTSRMSAAYVLEALHDANIRTRARDGLAHGRDLVERIVRQAVTDGHLSPDRDPATETNL
                     LLALTGLTPLVELGVIEPQEALTAVDQHLNRLFGKGT"
     gene            complement(886..1284)
                     /locus_tag="N1H47_RS02595"
                     /old_locus_tag="N1H47_02595"
     CDS             complement(886..1284)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018106107.1"
                     /locus_tag="N1H47_RS02595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02595"
                     /product="VOC family protein"
                     /protein_id="WP_016577778.1"
                     /transl_table=11
                     /translation="MNLVSLRMITHDVARLVAFYEGVTAVPATWSTPEFAELVTEACTL
                     AIASDRTVALFGADSARPAANHTVITEFRVADVDAAYARLTSLDCTFVQRPTTMPWGNR
                     SLLFRDPDGNLINFFTPVTPEAVRRQER"
     misc_feature    complement(1269..1283)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.28"
                     /tool="antismash"
     misc_feature    complement(1320..1333)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.46"
                     /tool="antismash"
     misc_feature    1380..1400
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            1391..2455
                     /locus_tag="N1H47_RS02600"
                     /old_locus_tag="N1H47_02600"
     CDS             1391..2455
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057360.1"
                     /locus_tag="N1H47_RS02600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02600"
                     /product="YafY family protein"
                     /protein_id="WP_037634935.1"
                     /transl_table=11
                     /translation="MTTTTTRVLALLEILQGGGIHPVPDLAARLAVDERTVRRYVGHLL
                     DLDVPVDAVRGRYGGYRLAPGYRMPPLMLTDEEALAVVLGLLAAQSAGLVTTSAAASES
                     AAAKLRRVLPKPLARRLAALLETADVTARPRPGAAPETAVLLGLAEATHQQRPVALTYT
                     DRKGRRTDRTVLPYGLVAHAGRWYLAGADPAAGGGDGDGDGEGAVRTFRLDRISALSVR
                     SGSFVVPATFDPVTRVLTGLARTPWAHEVSVRVRADVPHVRRHLPADLATVSPIAAAAG
                     TDDADPAERDGEPDGTPEADRDGWVRVRMRAERLDWIPPVLAALDRPFVIEHPAELRDL
                     VRALARRLDACADQ"
     gene            complement(2517..2867)
                     /locus_tag="N1H47_RS02605"
                     /old_locus_tag="N1H47_02605"
     CDS             complement(2517..2867)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268254.1"
                     /locus_tag="N1H47_RS02605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02605"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_020930405.1"
                     /transl_table=11
                     /translation="MHAPTPAVVTHAVEDQVFVIRVTGSLDHESAALLEEACALAESHA
                     ARRTVVDLSLTDFADSTVLHVLLGAQRAHHRRHRRLLVAGPFQPVVRRLFEVTGTTDYF
                     TLVDNVPTAVQE"
     gene            3152..4795
                     /locus_tag="N1H47_RS02610"
                     /old_locus_tag="N1H47_02610"
     CDS             3152..4795
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577781.1"
                     /locus_tag="N1H47_RS02610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02610"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_016577781.1"
                     /transl_table=11
                     /translation="MVNSAERSADNAWSDAALHAAPYPVLVADPVGTVRRANEAFGLLV
                     PDAVEGSALCEVLPDWLLLAHDRLSAAPAPHAPPPRGEVAGRSFEAHATRLPEGEVVWW
                     LTDDTDVRLAERRLLQERNRTAFLARASNELLSSLNLDRCMEVAGRLAAAHLADAAVVI
                     APPRGRALSVVSADGTRAHSRQLTGVAPESVPGLAEALRGFPPVPSRWIDPAAAPEWLV
                     PEDFGPVGAMVVTPLPGHGVPAGALVLLRRAHHAAFSESEESFARLFAARAGAAMSAAR
                     LYAEQAQITETLMRELLPPRVGQVGGVEFAARYRAAKDGERVGGDFYDIHPAAAPQDES
                     LVVLGDVCGKGLDAAVLTGKIRNTLHALLPLSGDHVRMLRLLNGALLSSHHTRFATLVM
                     ASARRRADRVELRVTCAGHPAPLVVRADGRVAEVETHGNLVGVLPEIDAVTAPLTLAPG
                     ESLVLFTDGITESKGGPLGDELFGDARLRRALAHCAGMPAEAVAEHVQMLATEWVGVNK
                     HDDMAVVTVTAPRGSSRRAPGGTPTEGHGA"
     gene            4792..5919
                     /locus_tag="N1H47_RS02615"
                     /old_locus_tag="N1H47_02615"
     CDS             4792..5919
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577782.1"
                     /locus_tag="N1H47_RS02615"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog.; Presence
                     of a B(12) (cobalamin)-binding domain implies dependence on
                     cobalamin itself, in one of its several forms, or in some
                     unusual lineages, dependence on a cobalamin-like analog.;
                     Presence of a B(12) (cobalamin)-binding domain implies
                     dependence on cobalamin itself, in one of its several
                     forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02615"
                     /product="B12-binding domain-containing protein"
                     /protein_id="WP_016577782.1"
                     /transl_table=11
                     /translation="MTTSSAPPAPLTAGDQVPFYTSRLWEAVRAGDEYAAGTGVRDALT
                     DGVPPETLLLDVIGGVQRRVGAEWAANRLSVAQEHAATAINERVIALLAQHPDVPPVPP
                     ARGRITVACVDGEWHALPARLLAEVLRLRGWRVDYLGAQVPAPHLIAHLHLTNPDLVAL
                     SSSLVTRLPAAHATITACQATGVPVLVGGAAFGSDGRHARQLGADAWAPDARQAAERLQ
                     RPLTRRKADHQAIDDLPHLADQEYTLVARGSRQLVREVLAGLETRFPALLDYDDVQRDH
                     TAQDVAHLVEFLTAALYTDDTELFSGFLVWTADVLRARAVPPESLLPALDLLERALRDF
                     PRAVGLITRSRQALSRALRASGPPAARQLDPGQPA"
     gene            5916..6287
                     /locus_tag="N1H47_RS02620"
                     /old_locus_tag="N1H47_02620"
     CDS             5916..6287
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577783.1"
                     /locus_tag="N1H47_RS02620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02620"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_016577783.1"
                     /transl_table=11
                     /translation="MTDPSPARILHLSSTAVGPDVLRITVRGELDVDSAAEFQDAVTEH
                     LAARSGLRALRVDCGGLVLCDSMGLSALLMVHRRTTALGVSLHLEERPPALDRLLAVTG
                     TLDHLTAPPAAAASTPPSS"
     gene            6409..6780
                     /locus_tag="N1H47_RS02625"
                     /old_locus_tag="N1H47_02625"
     CDS             6409..6780
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577784.1"
                     /locus_tag="N1H47_RS02625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02625"
                     /product="ATP-binding protein"
                     /protein_id="WP_016577784.1"
                     /transl_table=11
                     /translation="MALTAELPATSGEARDRVLALLRTGHRQVDDIVVADALLITSELV
                     TNALRHAGGVTGFTARISGDRLEVTVEDASPVHPFVPSDTRDGRIGGYGWSLVGRLATS
                     VVITSTAFGKGIHVTLRLR"
     misc_feature    6855..6868
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            7053..7442
                     /locus_tag="N1H47_RS02630"
                     /old_locus_tag="N1H47_02630"
     CDS             7053..7442
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577785.1"
                     /locus_tag="N1H47_RS02630"
                     /note="This anti-anti-sigma factor, or anti-sigma factor
                     antagonist, belongs to a family that includes characterized
                     members SpoIIAA, RsbV, RsfA, and RsfB; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="N1H47_02630"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_016577785.1"
                     /transl_table=11
                     /translation="MSHADLLSVEVTVIDERTAVAAVCGELDTATGTALHHQLANQLAH
                     GRRHLVLDLRDVPFMDSSGLGVIIRVHNDTKKVGGSVQLAAASPVVRRLLDLTGISVSM
                     PVQDTPEEALFALATASLPGPASSS"
     gene            7575..8459
                     /locus_tag="N1H47_RS02635"
                     /old_locus_tag="N1H47_02635"
     CDS             7575..8459
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577786.1"
                     /locus_tag="N1H47_RS02635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02635"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_016577786.1"
                     /transl_table=11
                     /translation="MTIVVNDTADPAQTTARDDGLPEVRRPRAVAPRDARALSKQFFDR
                     LQELEEGTHAYQYARNTLIEMNMSMVRYVARRYRHRGDDMEDIVQVGTIGLIKAIDRFD
                     LSREVEFSTFAVPYILGEIKRFFRDTGWAVHVPRRLQELRTELAKAKEQLHAALDRDPT
                     VAELAGHLKLSEEEVIEGLVAANGYSADSLDTPADPDPGDQRRALTEVLGAHDPALETV
                     EDLHTLAPLLRQLDARERRIIELRFGQEMTQSQIGAELGVSQMHVSRLLNRTLSRLRTG
                     MLKDGAPAPSPGS"
     gene            complement(8509..9678)
                     /locus_tag="N1H47_RS02640"
                     /old_locus_tag="N1H47_02640"
     CDS             complement(8509..9678)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577787.1"
                     /locus_tag="N1H47_RS02640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02640"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_016577787.1"
                     /sec_met_domain="MGT (E-value: 1.8e-43, bitscore: 148.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKHLLFVALLGHGHINPTLPLVEELVRRGHRVDYATSAEHAEAV
                     TRSGAHWVELPPLPPIDRPTEFGPETFGRFMRHLFAGMRTAYPVLREHCATTPVDAICY
                     DAMNWSARVLAEELDLPAVRLIPNFASNETYSLFAQFMTGTDGVHPITAAIGPDCAEFA
                     AEHGVALDPAHLLDATEKLNLVFIPREFQPAGDSFDERFHFIGPSLGSRADEPWSPPDP
                     EAPVLFVSLGTVFNDRPEFYRTCIDAFADEPYHVAMSVGGLDPAALGPIPASFDVRARF
                     PQPAVLQRATAFVSHTGMNSTMEALYYGVGLIAVPQMPEQAANAGRVQELGLGEQLDAR
                     TVTAEALRAAVARVASDDAVRANLDRMRKVVRESGGAVRGVEVIEEYLR"
     misc_feature    complement(9661..9663)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9755..9949)
                     /locus_tag="N1H47_RS02645"
                     /old_locus_tag="N1H47_02645"
     CDS             complement(9755..9949)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577788.1"
                     /locus_tag="N1H47_RS02645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02645"
                     /product="hypothetical protein"
                     /protein_id="WP_016577788.1"
                     /transl_table=11
                     /translation="MNDRLLSLVDGVVDLDEERLPLLTLREAQAAIELLRLLAAGDGEG
                     SHAARHLARNLGRRMPSEH"
     gene            complement(10001..11278)
                     /locus_tag="N1H47_RS02650"
                     /old_locus_tag="N1H47_02650"
     CDS             complement(10001..11278)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907887.1"
                     /locus_tag="N1H47_RS02650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02650"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_260222591.1"
                     /sec_met_domain="LANC_like (E-value: 3.7e-20, bitscore:
                     70.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLHSRTGHTAAVHPRPSPAREARWRAHALQDAVLLLDRYVERAG
                     TGQAPGAGGLPSDPGVPVLARLVADRGEPVATAAASRATAVWARTAGRGAGHPGLYDGG
                     LAGTLVGLRQAATLHPALHQVADRLADRLPARILAGAARTTPGAVTFRDYDLILGPAGT
                     LLALSSAAPERHRVLVRLGRCLAALCAADGLDGLRTHYPEHPQLGWLDGRINTGTGHGV
                     AGVLTALAVAARQAEEGDASAAPELAAALRRTSRWLRGQSFVDARGIRSWDGAGPEAAP
                     PGGARRRQAWCYGAPGVSWALWDAGDTLRDPAVRDFAGAAFDTLAAGYDEDFHLFGDHL
                     GDRLGLCHGAAGVLAVADALHRHARLPSATALRARLLAHLDAHRAGTRALGEERMGLLG
                     GAGGTLSAVLTATGGARDWLPCLGLR"
     gene            complement(11410..11580)
                     /locus_tag="N1H47_RS02655"
                     /old_locus_tag="N1H47_02655"
     CDS             complement(11410..11580)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS02655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_02655"
                     /product="hypothetical protein"
                     /protein_id="WP_020930403.1"
                     /transl_table=11
                     /translation="MPTTIELTDLDNLIGDLDARITESELPSAEAYTGGCSGVCTVIVC
                     DTVLFCSGVVC"
     CDS_motif       complement(11485..11580)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MPTTIELTDLDNLIGDLDARITESELPSAEAY"
                     /locus_tag="N1H47_RS02655_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(11410..11484)
                     /prepeptide="core"
                     /locus_tag="N1H47_RS02655_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-11.60"
                     /molecular_weight="2232.7"
                     /monoisotopic_mass="2231.0"
                     /core_sequence="TGGCSGVCTVIVCDTVLFCSGVVC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPTTIELTDLDNLIGDLDARITESELPSAEAY"
                     /leader_location="[11484:11580](-)"
     gene            complement(11559..14453)
                     /locus_tag="N1H47_RS02660"
                     /old_locus_tag="N1H47_02660"
     CDS             complement(11559..14453)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010475288.1"
                     /locus_tag="N1H47_RS02660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02660"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_020930402.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.3e-25,
                     bitscore: 88.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.1e-10, bitscore:
                     39.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRAPDAAGARPPAAAARPPGTVGPTALVRIAGLPGTLWASAGN
                     EPLFTWAADLAERDARHTARARALGDRLGIDVVPHPCLADAARGAVLALRRRLHAGTAP
                     GPADLPVLETVAGVDPLLADTLTELADRAADLAAARAACAAAVATDRARVGRLALDLLH
                     HDPVLRSHLGATAPRIAADFPRRAAAGEPWHGKRLRKYTGYVWRVAARAAAKTTPRDWL
                     GQLAAVPVFPAPALGAAAAGDSLVVPPARAGAGATSSMENVHLLWERLRDAGPAAAGPG
                     SLLALTPLHCPMPTGVLRCAVVDTGSRGSRLRRIELRRTPVLDAVLALLSPGPRPFAEV
                     EALIAARLNTPANGTPEGRRRAVTALRGFLQHLLRLGVLQLCAAPAQRRTHWTPAARIH
                     PPHHALDDHPAPATAAAPDARDGTGPHATDAAPPHQDATWFVDSYRTLDAGLDALALAR
                     ITRGLRLATRLAALRAEDRPPTNPTGTTAQPYPGPVDIGPEPRSVAELLTAPPADPSAE
                     PDRPTTATTRRRYEGWHPARTPGSGYAHLLAHLAAHLDDARIDLDGPLLDACHAPPEAP
                     ELLAAWPADCLLRPLDAEGPVAVLETVSPAGVLDARFAEALHALHAGRGGYPQPAAYRA
                     FLAALERAADVRFVEVLVPPLDARAANAVRRPVLTDWCTGDANLALYYGSYGDGEACGA
                     AAAATPRPPGGKAPRPVHHLPLDRLTLRSDGRQLIAEVDGARVFPVHHATRNPAPPYDR
                     LTRLLMAAAHPATQHVVQLGGLIGAFPTAGRVPRLSVGGDLVVSPAAWRVPVAELWEPG
                     AREADKVTSLAVLRRTRQLPRFCFARPAPGAKPVPVDLAALPTLHVLERLRAAAPDGAL
                     IVEEALPAPGRSPVRDAVHGGAPVAAQVQLRMPYDAHPEELAARAAAALRHWSAPPPPR
                     PRPQTTPDAPPEGRPPGRNRTPRKGGQSCPQPSN"
     aSDomain        complement(13296..13562)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_N1H47_RS02660_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.40E-28"
                     /identifier="RREFam001.1"
                     /label="N1H47_RS02660"
                     /locus_tag="N1H47_RS02660"
                     /protein_end="386"
                     /protein_start="297"
                     /score="88.8"
                     /tool="antismash"
                     /translation="LRCAVVDTGSRGSRLRRIELRRTPVLDAVLALLSPGPRPFAEVEA
                     LIAARLNTPANGTPEGRRRAVTALRGFLQHLLRLGVLQLCAAPA"
     gene            complement(14450..15433)
                     /locus_tag="N1H47_RS02665"
                     /old_locus_tag="N1H47_02665"
     CDS             complement(14450..15433)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010475286.1"
                     /locus_tag="N1H47_RS02665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02665"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_020930401.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.8e-07, bitscore:
                     29.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLMVTDLLADCLRNAGALEISALPACADASELPAARTAFLAAGLA
                     AVRQRTAGTSWVQFNLAPAPDGHLRAYDWLGTVARELLDTGRARNFFFMHKEPGLRVRF
                     EAPDGEREPLRAELARHFVERGGWRQPPSGAVYEPEQYLFGGRASMPYVHRLFTHDSLA
                     WLDHHARHPCPEGEATAWRRSLFMLREVFAGLGVVGWEHRGVWDVVREDTGRRLTTAAR
                     DGHGPGGGAAWRRAAEGIREFWTRPGERMLASFPEEQRASLAERAAALGEAARRWRTGY
                     FESGAATTGPRRAAAYAVVFHWNRARMSFARQCLLAEALADDGEAR"
     misc_feature    15556..15570
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.23"
                     /tool="antismash"
     misc_feature    complement(15560..15574)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.76"
                     /tool="antismash"
     misc_feature    complement(15851..15864)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.16"
                     /tool="antismash"
     gene            15970..17718
                     /locus_tag="N1H47_RS02670"
                     /old_locus_tag="N1H47_02670"
     CDS             15970..17718
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575712.1"
                     /locus_tag="N1H47_RS02670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02670"
                     /product="hypothetical protein"
                     /protein_id="WP_016575712.1"
                     /transl_table=11
                     /translation="MILSFPEKPATAPSNTPSPTDPSSPSDGPPSEQGLSEATRLLCAG
                     VYFDGQFRRRVIQELVEHEERPIAPSLGFDALPVLAHALSARRREAQTGLLLLAVWAVF
                     IGLDLADVGAQSLLPVPWFVAYGAVCVVSWLVRGTRSSLFALGRSVLKEATRGRLKAVL
                     PVLPFVVAVVYGAAVLTTLFRGGDAWIAVVFPVLLVPPIWAHRAHVVSVMRHQLGRETF
                     AGGRRAALPATAQYRRIGAAIAREQHARLAIYDPFRPFVGAGTPYKPWSVAMELKQQSW
                     ADSTEREAPESPSRPAPPSFTKRRPGSVPAPLTGREVVDLIKPRLEALRTSAAATSRDR
                     LRSLEVEELVYLPVGLARDEVDYGPDVIREHLERAVGEGAEARRHFLRVRVGAWDEQVA
                     ICLLVRIHTQGGMLVLEVAPHVLTPVRPEFKSVDVVAAHGGDGPLRDVIRSVLTSPSAG
                     CAAAVSLCQTAVSLMRTWLTMPEHALPDAPVASVRELGSVPELSLFQEMDISRYVKTLQ
                     DRIANGVQEALRNKGYETGVFDQYIINVGEGGVFIGGMSGGAVASGERALAKHTDASTE
                     TGGGRG"
     gene            17715..18323
                     /locus_tag="N1H47_RS02675"
                     /old_locus_tag="N1H47_02675"
     CDS             17715..18323
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="N1H47_RS02675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="N1H47_02675"
                     /product="hypothetical protein"
                     /protein_id="WP_020930400.1"
                     /transl_table=11
                     /translation="MTVQEPEPVHGREVGDDGTDAAPPGDAAAGGNRAGGGISIGVLTG
                     GAVAAGERAAAEDRSVRDGRSAPALPPADGPEAPAVPTSAAGGISIGVMTGGAAAAGAD
                     ARALDASTQPALDAPPELRAALGTLRQHLPLLTATDETSEIDARLADAEEEIDDTGRVR
                     RDRLQWLRDRLDLGATAVAGLASATAVVQQITQLLGGQG"
     gene            18335..18988
                     /locus_tag="N1H47_RS02680"
                     /old_locus_tag="N1H47_02680"
     CDS             18335..18988
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573301.1"
                     /locus_tag="N1H47_RS02680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02680"
                     /product="DUF3558 family protein"
                     /protein_id="WP_016573301.1"
                     /transl_table=11
                     /translation="MDQWDEEKQDWLEPARPVGGPPDGRSRRMLIVTGSAVVLVAAAVV
                     GLWQLARDGQPDSPGWSGAPPSAPGGGWSSSPGGGSVASPGSDGLAAAPDPCAALDANT
                     AAAWGLSAGRPNNPSDPQAGLKACSWSGTVGGAALTYTLIYAKDIPVSPEPTPTSVTGV
                     PSASVLGNDQGCAIVWPTSFGKVFVHVKADTGTQPNLCDSAATFATQVAPRVPS"
     gene            19159..19539
                     /locus_tag="N1H47_RS02685"
                     /old_locus_tag="N1H47_02685"
     CDS             19159..19539
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573302.1"
                     /locus_tag="N1H47_RS02685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02685"
                     /product="SH3 domain-containing protein"
                     /protein_id="WP_016573302.1"
                     /transl_table=11
                     /translation="MTHLSPFRRGAAVLACAGFLCGVLGTGTAAAASPAAATAGGGLGP
                     SKGRVIAKNGLELRDGPGTAYRAVGSLPYGTVVTIRCKVNGENVHGNPRWYEVGEGRVT
                     WLSARYVETLGTAPRWCADRHR"
     gene            complement(19634..20461)
                     /locus_tag="N1H47_RS02690"
                     /old_locus_tag="N1H47_02690"
     CDS             complement(19634..20461)
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467788.1"
                     /locus_tag="N1H47_RS02690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02690"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_168171788.1"
                     /transl_table=11
                     /translation="MPTMPPSGLPEARQHRQVAESFGTDAARYDRARPRYPDALVRRIA
                     AGLPGPDVPEVLDVGCGTGIAARQFRAAGCRVLGVEPDARMADVARALGTEVDVARFED
                     WDPADRAFDAVVAGTAWHWIDPVAGAERAARALRPGGLLAPFWNVFRFPDDVADAVVGA
                     CRRALPDAPFDVTALTKGALDAYRQVCARAADGIRDAGGFDEPQQWRHDWERTYTRDAW
                     LDQMPTLGAFTRIPPAALSDVLAGVGAAIDARGGSFTMGYATVALIAVRTETA"
     gene            20543..21136
                     /locus_tag="N1H47_RS02695"
                     /old_locus_tag="N1H47_02695"
     CDS             20543..21136
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008745713.1"
                     /locus_tag="N1H47_RS02695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02695"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_037634907.1"
                     /transl_table=11
                     /translation="MPTGVAIRDVREQLFGAAERILLQAGPNALTSRAVTTEAGCAKGV
                     LHRHFADFDAFLAELVRDRIGRIEDQATALRAAAGTGAVADRLTAALLDVFGPVAVAIV
                     SLVISRDGLRAQLRAGGSTGVPLLAEATAMLASYLTAERALGRVAADADVDVLAPTLIG
                     AGHLLFADREGTTPDAPAVHRVVTAVIAGVVREP"
     gene            complement(21215..22069)
                     /locus_tag="N1H47_RS02700"
                     /old_locus_tag="N1H47_02700"
     CDS             complement(21215..22069)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573305.1"
                     /locus_tag="N1H47_RS02700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02700"
                     /product="DUF4344 domain-containing metallopeptidase"
                     /protein_id="WP_016573305.1"
                     /transl_table=11
                     /translation="MGRWTGHTTRALLALALAAAVTGCTAGRDAAEPTDGAGRRSHGKG
                     GSNGFVVQYRTGGRAATATGYLRAHRILDAAADRLNATLKVPQPIPFVVRSCGAAEPAY
                     DPETGTIDFCTEHVDEIRERFRQAGPGPDRPGGTAAADAHVAAVLEETAYHEGAHALID
                     RLGLRFTGREEDVADQFAAVLLIGQGRAGERKARAAADDYALAAEETPLDATDLRDEHS
                     LDGQRAANYACYVYGAHPDRHEDLVGSDARLDAERAEGCPDEWAQARDGWRQLLTAHLK
                     RPL"
     gene            complement(22178..22759)
                     /locus_tag="N1H47_RS02705"
                     /old_locus_tag="N1H47_02705"
     CDS             complement(22178..22759)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573306.1"
                     /locus_tag="N1H47_RS02705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02705"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_260222592.1"
                     /transl_table=11
                     /translation="MQILAFPEAATPAELRTQVRELQEQAWPSGRGTAPGPTEPVHDPA
                     LRPRSMLLVDDGTVLAALDVLAKEIRHAGCDYTAGGLSTVVTRLEARGRGHGRRLVTAA
                     REALATGGYDVGLFTCDRPLRAFYESAGWHHLPGTVLVGGTPQAPFPSDRPGFDKVTMA
                     DFFSPRARQARAAFRDSRIALHPGNIDALW"
     gene            22907..24088
                     /locus_tag="N1H47_RS02710"
                     /old_locus_tag="N1H47_02710"
     CDS             22907..24088
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573307.1"
                     /locus_tag="N1H47_RS02710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02710"
                     /product="permease"
                     /protein_id="WP_016573307.1"
                     /transl_table=11
                     /translation="MSAVLHALSLTGSMTWEITWALILGFGLSAVVQAVVRKSTVVAAL
                     GDDRPRTLALAAGLGAASSSCSYAAVALARSLFRKGADFTAAMAFQIASTNLVVELGII
                     LALLMGWQFTAAEFVGGPVMIVVLALLLRAFLTPALLRAARAQADRGVAGSMEGHAAMD
                     MSVRRDGSFLRRLCSPEGVTATAHVFVMEWAAILRDLMAGLLVAGAIAAWVPDAFWRSF
                     FFDGHPLAAKFWGPLVGPLVAMASFVCSIGNVPLAVVLWKGGISFGGVVAFVFADLLIL
                     PILGIYRKYYGPRMALLLLGTFYVASAVAGCVVEFVFGGLGLVPDQARARIPQEGVTLN
                     YTTWLNVAFLALAAALLVRFFRTGGREMLRTMGGAPAGGRDDGHGDPAGRRGP"
     gene            24265..24942
                     /locus_tag="N1H47_RS02715"
                     /old_locus_tag="N1H47_02715"
     CDS             24265..24942
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151544.1"
                     /locus_tag="N1H47_RS02715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="N1H47_02715"
                     /product="response regulator transcription factor"
                     /protein_id="WP_016578943.1"
                     /transl_table=11
                     /translation="MRLLIVEDEKRLATTLAKGLAAEGFAVDVAHDGREGLHLATTQGY
                     DLLILDIMLPGMNGYRVCAALRAAGDETAILMLTAKDGEYDEAEGLDTGADDYLTKPFS
                     YVVLLARVRALLRRRTRGGSPVLRLGDLVVDPNGHRCARGEEEIPLTAKEFAVLEYLAS
                     RSGHVVSKAEILEHVWDFAYDGDPNIIEVYISALRRKIDAPFGRRSITTVRGAGYRLAA
                     DRG"
ORIGIN
        1 tccgaccggc ggctgcgcgt aggggatgcc gcggaagacc gcgtgccctc cccgccagca
       61 cccttcgacg agtccctccg cagtccgtgc tctcggtcgt tcggacatgc cagatccttc
      121 ccccgcgatc ggactcccag cttttaccgg tcagctgtaa tatgtcaacc gtatgaaata
      181 aggggaggcc gaccatgccc aagcaggtgg atcaccgcga acgccgcgag accatcgccc
      241 gagcgctgtg gcgcgtagtg gaagaacgcg gcatcgcgca ggcgagcgtc cgcgaggtgg
      301 cccaggaagc gggcctctcc cacggcgcgg tgcagcacta cttcgccacc cgggaagaga
      361 tggtggtctt cgccatggac ttcgcgtccg cacagacgtc gctgcgcgtc gccgaaggcg
      421 tcagcggact cggcgaccca ccgcaccccc gcgacctgct ccgcgtgatg ctcgtggaga
      481 tgctccccct ccgtcccgac gcacgcacga cgagccggat gagcgccgcc tacgtcctgg
      541 aggcactgca cgacgcgaac atccgcaccc gcgcacgtga cgggttggcg cacggccgcg
      601 acctcgtcga gcggatcgtc cgccaggccg tcaccgacgg ccacctcagc cccgaccgcg
      661 acccggcgac cgagaccaac ctgctcctgg cgctcaccgg cttgacccca ctcgtcgaac
      721 tgggcgtgat cgagccccaa gaggccctga ccgccgtcga ccagcatctc aaccggcttt
      781 tcggcaaggg aacttgaccg cgccccagcg cctgcggtga cgtcccggta cggacggccc
      841 acgagacgga cggagcccga gcgcgccact gccccggacg ggctgctacc gctcctgccg
      901 tcgcacggcc tcgggggtga cgggcgtgaa gaagttgatc agatttccgt ccgggtcccg
      961 gaagaggagg gagcggttgc cccacggcat ggtcgtcggc cgctggacga acgtgcagtc
     1021 cagcgacgtc aggcgcgcgt acgcggcatc gacgtcggcg acgcggaatt cggtgatcac
     1081 ggtgtggttg gcggccggtc gggcggagtc ggcgccgaac agcgccacgg tgcggtcact
     1141 ggcgatcgcc agcgtgcacg cctccgtcac caactcggcg aattccgggg tggaccacgt
     1201 cgcggggacg gcggtgaccc cttcgtagaa cgcgacgaga cgggccacgt cgtgggtgat
     1261 catgcggagg gaaacgaggt tcacgaacgg ctcctaggga gaggcgacgc cggatgcggc
     1321 gaacggacgt ctgaacgtta gaaccaatag cggacaggat ccgcccggta tgggcggcag
     1381 acttgtccgg gtgaccacta cgaccactcg ggtgctcgcc ctgttggaga tcctccaggg
     1441 cggcggcatc caccccgtcc ccgacctggc cgctcgcctg gcggtcgacg aacgcaccgt
     1501 ccgccgctat gtgggccacc tgttggatct cgacgtgccc gtcgacgcgg tccgcggccg
     1561 ctacggcggc taccgactcg cccccggcta ccggatgccg ccactgatgc tcaccgacga
     1621 ggaggcgctg gccgtcgtgc tcggcctcct ggccgcacag tcggcaggac tggtcaccac
     1681 ctcggccgcg gcgagcgaga gcgccgcggc gaagctgcgg cgcgtgctgc ccaagcccct
     1741 ggcgcggcgc ctggcagcgc tgttggagac ggccgacgtc accgcacggc cgcgccccgg
     1801 cgccgctccg gagacggccg tgctgctcgg cctggcggag gccacccacc agcaacggcc
     1861 ggtggcgctc acctacaccg atcgcaaggg ccgccgcacc gaccgcaccg tcctgcccta
     1921 cggcctcgtg gcgcacgccg gacgctggta cctggccggc gcggatccgg ccgccggcgg
     1981 cggggacggg gacggcgacg gcgagggggc cgtgcgaacc ttccggctgg accggatctc
     2041 cgccctgagc gtgcgctccg gctcgttcgt cgtcccggcg acgttcgatc cggtgacacg
     2101 ggtgctgacc ggcctcgcgc ggacgccctg ggcccacgag gtgtccgtgc gcgtccgtgc
     2161 cgacgtgccg cacgtccgca ggcacctccc ggccgacctc gcgacggtgt ccccgatcgc
     2221 cgccgcggcg gggaccgacg acgcggatcc ggccgaacgc gacggcgaac ccgacggaac
     2281 gcccgaagcg gaccgggacg gttgggtgcg ggtccggatg cgcgccgagc ggctggactg
     2341 gattccgccc gtactggccg cactggaccg cccgttcgtc atcgagcacc ccgcggaact
     2401 gcgcgacctc gtgcgtgcac tggcccggcg cctggatgcc tgcgcggatc agtgagggcg
     2461 tggtcggacc ggggtgcgcc cgccggcgtc cgcgggcccc ggcggcccga gtggggtcac
     2521 tcctgcacgg cggtcgggac gttgtcgacg agggtgaagt aatcggtcgt gccggtgacc
     2581 tcgaagaggc ggcgcaccac cggctggaag gggccggcca ccaggagcct gcggtgccgg
     2641 cggtggtggg cccgttgcgc gccgagcagg acgtggagga cggtggagtc cgcgaagtcg
     2701 gtgagggaga ggtcgaccac cgtccttcgg gccgcgtgcg actccgccaa cgcacacgcc
     2761 tcttccagga gagcggcact ctcgtggtcg agggagccgg tgacgcggat gacgaacacc
     2821 tgatcctcaa ctgcgtgggt gaccacggcc ggtgtgggtg cgtgcatggg tgacaggatg
     2881 tcacggatgg tggtcgcagc actcccggag atcacgggtc cggccgaaat gagcgtgcac
     2941 gtgacgcgtc cgtccggccc gcgccgggga ccgccggccg gcccccgcgg cgggcggcag
     3001 ggccaccgga tgatcggcac acgcagcggc gcggaggaat tggccggggg cggattgcgc
     3061 gcggaagccg ggcggtggaa tggtgggccg cagcccccgc cggcacgatc aggaaaggtg
     3121 agcggctccg gacggccccg gggcccgaca cgtggtgaac tccgcagaac gctcggccga
     3181 caacgcctgg agcgacgcgg cgctgcacgc tgcgccctac ccggtcctcg tggccgaccc
     3241 cgtgggaacg gtgcgtcggg ccaacgaggc gttcggcctg ctggtgcccg acgccgtcga
     3301 gggcagcgca ctgtgcgagg tgctgcccga ctggctcctg ctggcccacg accggctgtc
     3361 cgcggcaccc gcaccgcatg cgccgccgcc gcggggcgag gtggccggcc gcagcttcga
     3421 ggcccatgcg acccgcctgc ccgagggcga ggtggtgtgg tggctgaccg acgacaccga
     3481 cgtccggctg gccgaacgcc gcctgctcca ggagcgcaac cggaccgcgt tcctggcccg
     3541 ggcctccaac gaactgctgt cgtcgctgaa cttggaccgg tgcatggagg tggccggccg
     3601 gttggcggcc gcccacctcg cggacgcggc cgtcgtcatc gctcccccgc gcggccgggc
     3661 gctgtcggtg gtgtccgccg acggcaccag ggcgcacagc cgccaactga ccggtgtcgc
     3721 accggagtcg gtgcccggcc tcgccgaggc gctgcgcggg ttcccgccgg tgccgtcccg
     3781 ctggatcgat cctgcggcgg ccccggagtg gctggtgccc gaggacttcg gtcccgtggg
     3841 ggcgatggtc gtcaccccgc tgcccggcca cggcgtgccg gccggtgcgc tggtgctgct
     3901 gcggcgggcc caccacgccg cgttcagcga gagcgaggag tccttcgcgc ggctcttcgc
     3961 ggcccgggcc ggggcggcga tgtccgcggc ccggctctac gcggaacagg cccagatcac
     4021 cgagacgttg atgcgcgagc tgctgccgcc gcgcgtcggc caggtcggcg gcgtggagtt
     4081 cgcggcccgc taccgcgcgg ccaaggacgg cgagcgcgtc ggcggcgact tctacgacat
     4141 ccacccggcc gcggcgccgc aggacgagtc gctggtggtg ctgggcgacg tctgcggcaa
     4201 ggggctggac gccgcggtgc tcaccggaaa gatccgcaac accctgcacg cgctgctgcc
     4261 gctgtccggg gaccacgtgc ggatgctccg gctgctcaac ggcgcactgc tcagctccca
     4321 ccacacccgc ttcgcgacgc tcgtcatggc ctccgcacgc cgccgggcgg accgggtgga
     4381 gctgcgggtg acgtgtgccg ggcaccccgc tccgttggtc gtccgggcgg acggccgggt
     4441 ggcggaggtc gagacccacg gcaacctcgt cggcgtgctg ccggagatcg atgcggtgac
     4501 cgccccgctc accctcgccc ccggcgagtc cctggtgctc ttcaccgacg gcatcaccga
     4561 gtccaagggc ggcccgctgg gcgacgaact cttcggcgac gcacggctgc gacgggcgct
     4621 cgcccactgc gcggggatgc ccgccgaggc agtggcggag cacgtccaga tgctggcgac
     4681 ggagtgggtc ggagtcaaca agcacgacga catggccgtg gtgaccgtca ccgcgccgcg
     4741 gggctcttcg cgccgggcgc cgggcggtac cccgacggag ggacacggtg catgacgacg
     4801 tcctcggcgc cccctgcccc gctcaccgcc ggggaccaag tccccttcta cacaagccgg
     4861 ttgtgggagg cggtccgtgc cggtgacgag tacgccgccg gcaccggcgt ccgggacgcg
     4921 ctgacggacg gcgtgccgcc ggagaccctg ctgctggacg tcatcggcgg cgttcagcgg
     4981 agggtcggcg cggagtgggc ggcgaaccgg ctgagcgtgg cgcaggagca cgcggccacc
     5041 gcgatcaacg agcgggtcat cgccctgctc gcgcagcacc cggacgtccc gcccgtaccg
     5101 ccggcgcgcg gccggatcac cgtggcctgc gtggacggcg agtggcacgc gctgccggcc
     5161 cggctgttgg ccgaggtgct ccggctgcgc ggctggcggg tggactacct cggcgcgcag
     5221 gtcccggctc cgcacctgat cgcccacctc cacctcacca acccggacct ggtggcgctg
     5281 tcgagttccc tggtcacccg gctgcccgcc gcgcacgcca cgatcaccgc ctgccaggcc
     5341 accggggtac cggtgctggt gggcggggcg gccttcggga gtgacggccg tcacgcacga
     5401 cagttgggtg ccgatgcctg ggcgccggac gcccgccagg cggcggagcg gctgcagcgc
     5461 cccctgaccc gccggaaggc ggaccaccag gcgatcgacg acctgccgca cctggcggac
     5521 caggagtaca cgctggtcgc caggggctcc cgacagttgg tgcgggaggt gctggccggt
     5581 ctggagaccc gtttccccgc gctgctggac tacgacgacg tacaacggga ccacaccgcg
     5641 caggacgtcg cgcacctcgt ggaattcctc accgccgccc tctacaccga cgacaccgag
     5701 ctgttcagcg gtttcctggt gtggacggcg gacgtcctgc gcgcccgagc ggtgcccccg
     5761 gaatcgctgc tgcccgccct ggacctgctg gagcgcgcgc tgcgggactt cccccgggcc
     5821 gtgggactga tcacccgcag tcggcaggcg ctctcccgcg ccctgcgcgc ctccgggccg
     5881 cccgccgccc gacagctcga ccccggacag cccgcatgac cgatccgtcc cccgcccgga
     5941 tactccacct ctcctcgacg gccgtcggtc ccgacgtgct gcggatcacg gtgcgcggcg
     6001 aactcgacgt cgacagcgcc gccgagttcc aggacgccgt gaccgagcac ctcgccgccc
     6061 gcagcggcct gcgggccctg cgcgtggact gcggcgggct ggtgctgtgc gactccatgg
     6121 gcctgtccgc gctgctgatg gtccaccgtc gcaccaccgc gctgggggtg tcgttgcacc
     6181 tggaggagcg cccacccgca ctcgaccggc tactggccgt gaccggcacg ttggaccacc
     6241 tgacggcccc gcccgctgcc gccgcgtcca ctccaccgtc gtcgtgaagt gggaacggcc
     6301 cgggcgtgac ccggccgtgt ggcagagtga ccctctgatg cacgaatcgc agtacggcgg
     6361 gtagacgcac acccgaggcc ggaccctgca ccaccaagga ggtgaacggt ggctctcacc
     6421 gcggaactgc ccgctacctc aggcgaagcg cgtgaccgcg tgctcgccct gctgcgcacc
     6481 ggccaccggc aggtcgacga catcgtggtg gccgacgcct tgttgatcac ctcggaactg
     6541 gtcaccaacg ccctgcggca cgccggtgga gtcaccggct tcaccgcccg catcagcggc
     6601 gatcggctcg aagtgaccgt cgaagacgcc agcccggtcc acccgttcgt gccgtccgac
     6661 acccgtgacg gccggatcgg cggctacggc tggtcgctgg tcggtcggct cgccacgtcg
     6721 gtcgtgatca cctcgacggc gttcggcaag ggcatccacg tcacgctgcg cctgcggtga
     6781 gcagcaccgg ggcgcgcgtc cgggcatttc gcgaacacca ggaatagccg gagatcatcg
     6841 gggcaggcga cccctcgtca cggatcaaga acgaggtccg cccggagccg gccgacgcct
     6901 ggcgcggtct gccggacccg ctccactcgg ggccggcacg gacggactgc acgaccgggt
     6961 ctgccccggt gacctgcgcc ttccggcggc acgagccgcc cagcgcaccg tcggtccacc
     7021 acggggtcga tccacgacaa gggagccgac acatgtcgca tgccgatctg ctgagcgtgg
     7081 aagtcaccgt catcgacgag cggacggcgg tggcggccgt gtgcggtgag ctcgacaccg
     7141 ccaccggaac cgccctgcac caccagctcg ccaaccaact cgcccacggc cgacgccatc
     7201 tcgtgctcga cctgcgcgac gtgccgttca tggattcctc ggggctgggc gtcatcatca
     7261 gggtgcacaa cgacaccaag aaggtgggcg gaagcgtgca actggccgcc gcttccccgg
     7321 tggtccggcg gctgctcgac ctgacgggga tcagtgtcag catgccggtc caggacaccc
     7381 ccgaggaggc gctgttcgcg ctggccaccg cctccctgcc gggcccggcg tcgtcctcct
     7441 gaggcccccc gagcggcgct cgcggtgccc ggaccccgtt ccggccggat tcctccgcgg
     7501 cacgcatgcc tcggcacgga cggggtaagc gccggcaagg gtgcccgcgg gggtcgggca
     7561 cggagggaga cgtgatgacc atcgtcgtga acgacaccgc ggatccggcg cagaccacgg
     7621 cacgcgacga cggtctcccg gaggtcaggc ggccgcgtgc cgtggcgccg cgggacgccc
     7681 gcgcgctctc caagcagttc ttcgaccggc tgcaggagct cgaagagggc acccacgcgt
     7741 accagtacgc acggaacacg ctgatcgaga tgaacatgtc gatggtgcgc tacgtcgccc
     7801 gtcgctatcg ccatcgcggc gacgacatgg aggacatcgt ccaggtcggc accatcggcc
     7861 tgatcaaggc gatcgaccgc ttcgacctct cccgcgaggt ggagttctcc accttcgccg
     7921 tcccgtacat cctcggtgag atcaagcggt tcttccggga caccggctgg gccgtgcacg
     7981 tgccgcgccg gttgcaggag ctgcgcaccg aactcgccaa ggccaaggag cagttgcacg
     8041 ccgcgctcga ccgcgacccc accgtcgcgg agctcgcggg gcacctgaag ctgtcggagg
     8101 aggaggtgat cgagggactc gtcgcggcca acggctattc cgcggactcc ctggacaccc
     8161 cggccgaccc cgacccgggc gaccagcggc gcgcgctgac ggaggtgctg ggcgcccacg
     8221 acccggccct ggagaccgtc gaggacctcc acaccctcgc gccgctgctg cggcaactcg
     8281 acgcccgcga acggcgcatc atcgagctcc gcttcggtca ggagatgacc cagtcgcaga
     8341 tcggggccga gctcggcgtg tcgcagatgc acgtctcccg cctgctcaac cgcacgttga
     8401 gccggctgcg caccggcatg ctcaaggacg gcgcgccggc cccgtcgccc ggctcctgat
     8461 ggcggtggcc ggtgcgcccc accgccgtgg gacggaccgg ccggccgctc agcgcaggta
     8521 ctcctcgatc acctcgacac cgcgcacggc gccgccgctc tcccggacga ccttccgcat
     8581 ccggtcgagg ttggcgcgga ccgcgtcgtc ggacgcgacc ctggccaccg cggcccgcag
     8641 cgcctccgcg gtcaccgtgc gggcgtcgag ctgctcgccg agcccgagct cctgcacccg
     8701 tccggcgttg gcggcctgtt cgggcatctg cgggacggcg atcaggccga cgccgtagta
     8761 cagggcctcc atcgtggagt tcatgccggt gtgcgagacg aaggcggtgg cccgctggag
     8821 cactgccggc tgcgggaacc gcgcacggac gtcgaacgac gccgggatcg gccccagggc
     8881 ggccgggtcc agcccgccca ccgacatcgc cacgtggtag ggctcgtcgg cgaaggcgtc
     8941 gatgcaggtg cggtagaact cggggcggtc gttgaagacc gtgcccagcg agacgaacag
     9001 caccggggcc tcggggtccg gcggcgacca cggttcgtcc gcgcggctgc cgagcgaggg
     9061 acctatgaag tggaaccgct cgtcgaagga gtcgccggcg ggctggaact ccctcggtat
     9121 gaacaccagg ttgagtttct cggtggcgtc cagcaggtgc gccgggtcga gcgcgacacc
     9181 gtgttccgcg gcgaactccg cgcagtcggg gccgatggcc gccgtgatcg ggtgcacccc
     9241 gtcggtgccg gtcatgaact gggcgaagag cgaatacgtc tcgttcgagg cgaagttggg
     9301 gatcagccgg acggccggca ggtccagttc ctcggcgagc acccgggcgg accagttcat
     9361 ggcgtcgtag cagatcgcgt ccaccggcgt ggtggcgcag tgctcccgga gcaccgggta
     9421 ggccgtgcgc attcctgcga agaggtggcg catgaagcgg ccgaaggtct ccgggccgaa
     9481 ttcggtgggc cggtcgatcg gcgggagcgg cggcagctcc acccagtggg ccccggacct
     9541 ggtgaccgcc tcggcgtgtt ccgcgctggt ggcgtagtcc acgcggtggc cgcggcggac
     9601 gagttcctcg accagcggaa gtgtggggtt gatgtgcccg tgaccgagca gggccacgaa
     9661 taacaggtgt ttcgccatgg cgaaaatcct atcgatcgtg gattctcgcc tcccgtccgc
     9721 ccctcgcccg gcgccccgcc ggcaccggcc gcggtcagtg ttccgagggc atccggcgcc
     9781 cgaggttccg cgccaagtgc cgggcggcgt gcgacccttc gccgtcgccc gccgccagca
     9841 ggcgcagcag ctcgatcgcg gcctgtgcct cgcgcaaggt gagcaggggc agtcgttcct
     9901 cgtccagatc caccacaccg tcgacgaggc tgaggaggcg gtcgttcata gcgctcatgg
     9961 acgggttaac ggccactcac atcgctggtt acggcggggg tcagcgcagg cccaggcagg
    10021 gcagccagtc gcgggcgccg ccggtggcgg tgagcacggc gctcagggtg ccgccggcgc
    10081 ctcccagcag gcccatccgt tcctctccca gcgcgcgggt gccggcccgg tgggcgtcga
    10141 ggtgcgccag gaggcgggcg cgcagtgcgg tggccgacgg cagtcgagcg tgccggtgca
    10201 gcgcgtcggc gacggccagc accccggcgg cgccgtggca gaggccgagg cggtcgccga
    10261 ggtggtcgcc gaagaggtgg aagtcctcgt cgtagccggc ggcgagggtg tcgaaggcgg
    10321 cgccggcgaa gtcccggacc gcggggtccc ggagggtgtc cccggcgtcc cacagcgccc
    10381 agctgacgcc gggggctccg tagcaccacg cctgtcggcg gcgggccccg ccgggcgggg
    10441 cggcttccgg ccccgcgccg tcccaggagc gaatgccccg cgcgtcgacg aacgactggc
    10501 ctcgcagcca acggctcgtc cggcgcaggg ccgcggcgag ttccggggcc gcgctcgcat
    10561 ccccctcctc cgcctgccgg gcggccaccg cgagggcggt caggacgccg gcgacgccgt
    10621 ggcccgtgcc cgtgttgatc cgcccgtcca gccagcccag ttgcggatgt tccggatagt
    10681 gggtgcgcag tccgtcgagc ccgtcggcgg cgcagagcgc ggccaggcac cggccgaggc
    10741 ggacgagcac gcggtgccgc tccggggcgg cggagctcag tgcgaggagg gtgccggcgg
    10801 ggccgaggat caggtcgtag tcccggaagg tgaccgctcc gggggtggtg cgtgcggcgc
    10861 cggccaggat gcgtgcgggg agccggtcgg cgaggcggtc ggcgacctgg tgcagggccg
    10921 ggtggagggt ggccgcctgg cgcagcccga cgagggttcc ggcgagcccg ccgtcgtaga
    10981 ggcccgggtg gcccgccccg cgtccggcgg tgcgggccca cacggcggtg gcgcggctcg
    11041 ccgcggccgt ggcgacgggt tcgccgcggt cggcgaccag tcgggcgagg accgggacgc
    11101 ccgggtccga ggggaggccg ccggcgcccg gtgcctggcc ggtgccggcc cgctcgacgt
    11161 accggtcgag gagcagcacg gcgtcctgga gggcgtgggc ccgccaccgg gcctcccgag
    11221 cgggtgaggg gcgcgggtgc acggcggcgg tgtgtccggt gcgggagtgc aggggcatgg
    11281 gtgcggcgtc ctccagggca gggagccgtc cggcgggatg ccggacggct cgttcaacct
    11341 cttctgctgt gaactgcgtt gacggtccgt cgcgccgcgg tgctcatccg cggcgggtgg
    11401 atcctcgggt cagcagacga ccccggaaca gaagagcacc gtgtcgcaga cgatgaccgt
    11461 gcagacgccg gagcagccgc cggtgtacgc ctcggcgctg ggcagttcgg actcggtgat
    11521 ccgggcgtcc agatcgccga tgaggttgtc gaggtcggtc agttcgatgg ttgtgggcat
    11581 gactgccctc cttttctcgg tgtgcggttc cgccccgggg gccgtccctc tggaggggcg
    11641 tccggggtgg tctggggcct cggtcgaggc gggggcggtg cggaccagtg ccgcagggcc
    11701 gcggcggcgc gggccgccaa ctcctcgggg tgggcgtcgt acggcatccg cagctgcacc
    11761 tgggcggcga cgggtgcccc accgtgcacg gcgtcgcgca ccggcgagcg gccaggtgcg
    11821 ggcagcgcct cctcgacgat caacgccccg tcgggcgcgg cggcccgcag tcgttccagg
    11881 acgtgcaggg tgggcagcgc cgccaggtcc accggtaccg gtttggcacc gggcgccggg
    11941 cgggcgaagc agaagcgcgg cagctgccgg gtgcgccgga ggacggcgag ggacgtcacc
    12001 ttgtcggcct cccgggctcc gggctcccac agttccgcga cgggcacccg ccacgcggcg
    12061 gggctgacga ccaggtcccc gcccaccgac agccggggca cccgaccggc cgtggggaac
    12121 gccccgatca ggccgcccag ttggaccacg tgctgggtgg ccgggtgggc ggccgccatc
    12181 agcaggcggg tgagccggtc gtagggcggg gcggggttcc gggtggcgtg gtggacgggg
    12241 aagacccgcg ccccgtcgac ctcggcgatg agctggcgcc cgtcggagcg gagggtgagc
    12301 cggtcgaggg gtaggtggtg gacggggcgg ggagccttcc cgcccggcgg ccggggcgtc
    12361 gccgcggccg ccgctccgca tgcctcgccg tcgccgtaac tcccgtaata gagagccagg
    12421 ttggcatctc cggtgcacca gtcggtcagc acgggacgcc gtacggcgtt ggcggcgcgg
    12481 gcgtccaacg gggggaccag cacctcgacg aagcggacgt ccgcggcccg ttcgagggcg
    12541 gcgaggaagg cccggtaggc ggccggttgg gggtagccgc cccgaccggc gtgcagggcg
    12601 tgcagggcct cggcgaaccg ggcgtcgagc acgccggccg gggagaccgt ctccaggacg
    12661 gcgaccggcc cctcggcgtc gagcgggcgc agcaggcagt ccgccggcca ggcggccagg
    12721 agttcggggg cctcgggcgg ggcgtggcag gcgtccagca gcgggccgtc gaggtcgatc
    12781 cgcgcgtcgt cgaggtgggc tgcgaggtgg gcgagcaggt gggcgtatcc ggaaccgggc
    12841 gtcctggcgg ggtgccagcc ttcgtagcgg cggcgcgtgg tggcggtggt cgggcggtcc
    12901 ggctcggcgg aggggtcggc gggcggggcg gtcaggagtt cggcgaccga gcgcggttcg
    12961 gggccgatgt ccaccggtcc cgggtacggc tgggcggtgg taccggtggg gttcgtgggg
    13021 ggacggtctt cggcgcgcag ggcggcgagc cgggtggcga gccgcaggcc gcgggtgatc
    13081 cgggccaggg cgagggcgtc gaggccggcg tcgagggtgc ggtaggagtc gacgaaccac
    13141 gtggcgtcct ggtggggcgg cgcggcgtcg gtggcgtgcg ggccggtgcc gtcgcgagcg
    13201 tccggggccg ctgcggtcgc cggggccggg tggtcgtcga gggcgtggtg cggcgggtgg
    13261 atccgtgcgg cgggggtcca gtgcgtgcgg cgttgcgccg gcgcggcaca gagttgcagg
    13321 acgcccagcc gcaggaggtg ctggaggaac ccgcggagcg cggtgacggc ccgccgccgc
    13381 ccttcagggg tgccgttcgc cggggtgttc aggcgcgccg cgatcagggc ctcgacctcg
    13441 gcgaacgggc gggggccggg cgagaggagc gccaggaccg cgtccaggac cggtgtgcgg
    13501 cgcagttcga tccggcgcag ccgggagccc cgggagccgg tgtcgacgac cgcgcagcgc
    13561 agcacgccgg tgggcatcgg gcagtgcagg ggcgtcaggg cgagaaggct gccggggccg
    13621 gcggcggccg gtccggcgtc ccggagccgt tcccacagca ggtggacgtt ctccatgctg
    13681 ctggtggcgc cggccccggc ccgggcgggc ggcacgacga gggaatcacc ggccgcggcg
    13741 gcgccgagtg cgggtgcggg gaagacgggg acggcggcga gttggccgag ccagtcgcgc
    13801 ggggtggtct tggcggcggc ccgggcggcc acccgccaga cgtagccggt gtacttgcgc
    13861 agccgtttgc cgtgccaggg ttcgccggcg gccgcccggc gggggaagtc cgcggcgatc
    13921 cggggtgcgg tggcgccgag gtggctgcgc aggacggggt cgtggtgcag caggtcgagg
    13981 gccagccggc ccacccgtgc gcggtcggtg gcgaccgcgg cggcgcatgc ggcccgcgcc
    14041 gcggccaggt ccgcggcccg gtcggccagc tccgtgaggg tgtcggccag caacgggtcg
    14101 acgccggcca ccgtctccag gacggggagg tccgcgggtc cgggggcggt cccggcgtgc
    14161 agtctgcggc gcagggcgag caccgcgccg cgggcggcgt cggccaggca cgggtgcggc
    14221 acgacgtcga tcccgagccg gtcccccagt gccctggccc gggcggtgtg gcgtgcgtcc
    14281 cgctccgcca ggtcggcggc ccaggtgaag agcggttcgt tgccggcgga cgcccagagc
    14341 gtgcccggca gtccggcgat gcggaccagt gcggtcggcc cgacggtgcc gggcgggcgg
    14401 gccgccgcgg ccggtgggcg ggcgccggcc gcgtccggcg cgcggcgcgt catcgggcct
    14461 ccccgtcatc ggcgagcgcc tcggccaaca ggcactgccg ggcgaacgac atccgcgccc
    14521 ggttccagtg gaagaccacc gcgtaggcgg cggcgcgccg cgggccggtg gtggcggcgc
    14581 ccgactcgaa gtagccggtg cgccaccgtc gggccgcctc gcccagggcc gcggcacgct
    14641 cggcgaggga cgcccgctgt tcctcgggga acgaagcgag catccgctcg ccgggccgtg
    14701 tccagaattc ccggatgccc tcggcggccc gccgccacgc cgcccctcct ccgggcccgt
    14761 gcccgtcgcg ggcggcggtg gtgagccggc gtccggtgtc ctcgcgtacg acgtcccaca
    14821 cgccccggtg ctcccacccg accactccca gccccgcgaa cacctcccgc agcatgaaca
    14881 gcgagcgccg ccaggccgtg gcctccccct cggggcacgg atggcgggcg tggtggtcca
    14941 gccaggccaa cgagtcgtgc gtgaacagcc ggtgcacgta gggcatcgac gcccggccgc
    15001 cgaagaggta ctgctcgggt tcgtacaccg cacccgacgg cggctgccgc caaccgcccc
    15061 gttcgacgaa gtgccgcgcc aactccgccc gcagcggctc ccgttcgccg tccggcgcct
    15121 cgaaccgcac ccgcagtccg ggctccttgt gcatgaagaa gaagttgcgg gcgcggccgg
    15181 tgtcgaggag ttccctggcg acggtgccca gccagtcgta cgcccggagg tgaccgtccg
    15241 gcgcgggcgc gaggttgaac tggacccagg acgtccccgc ggtccgctgc cgcacggcgg
    15301 ccaggccggc ggccaggaac gcggtgcggg cggcggggag ttcggaagcg tccgcacagg
    15361 cggggagggc ggatatctcc agggctccgg cgttgcggag acagtccgcg agcaggtccg
    15421 tgaccatcag catgtacgtt cctccggcac cgagcaccga agccccgccg gtcggccggg
    15481 gcacaggaat gcggggcccg aatcgccccg cccaaacgcc ttcccggccc gctcaccgat
    15541 aacgtcatta tctgcattct tcatatattg agcagttgtg cgccggaggt ccgaggtctc
    15601 gcatcgccgg cttgcgccgt ggtgcacgac ggcccggcac cgcaaggcgc gttcccaccg
    15661 gcgccgacgc cgttccgccc gccgagcgct cccgggcgcg acggacctcc cgccgggtgc
    15721 gcacggctcc cccgccaccg cccgcacctc cggccgtacc gcccctcgcg ccccaggggt
    15781 ggctcccggc gcacgcgcgg gcgcaggcgc cgaaagcaac ggccgtcttg ggcgtcaact
    15841 catcgtcaca gcaaaggagt tgccaagccg acggaacccc ttccgggtcc ggcgaccggg
    15901 agtcatactg cccccatagc aactccgtca acacctcgca acaggggacg agttcgatca
    15961 cgggggtgca tgatcttgtc cttccccgaa aaaccagcga ccgctccgtc gaacactcca
    16021 tcgccgacgg acccctcctc gccatccgac ggaccgccct ccgaacaggg cctcagcgaa
    16081 gccacccgcc tgctgtgcgc gggggtctac ttcgacggac agttccgtcg ccgcgtcatc
    16141 caggaactgg tcgaacacga ggagcgcccg atagcgccct cgctcggttt cgacgccctg
    16201 ccggtcctcg cccacgcgct gtcggcgcgc cgccgggagg cgcagaccgg gctgttgctg
    16261 ttggccgtct gggccgtatt catcgggctc gacctggccg acgtcggtgc gcagtcgctc
    16321 ctccccgtgc cgtggttcgt ggcctacggg gcggtctgcg tcgtgtcctg gctcgtgcgt
    16381 ggaaccagga gttccctctt cgccctcggg cgctcggtgc tcaaggaggc cacccgcggc
    16441 cggctgaagg cagtgctgcc ggtactgccg ttcgtggtgg cggtggtgta cggggcggcc
    16501 gtgctcacca ccctgttccg cggcggcgac gcctggatcg ccgtggtgtt cccggtcctg
    16561 ctggtgccgc cgatctgggc gcaccgggcg cacgtcgtct ccgtcatgcg gcaccaactc
    16621 ggccgcgaga ccttcgccgg ggggcggcgg gcggcgctgc cggccaccgc ccagtaccgg
    16681 cgcatcgggg cggccatcgc ccgcgaacag cacgcccggc tggccatcta cgacccgttc
    16741 cggcccttcg tcggcgccgg cacaccgtac aagccgtggt cggtcgccat ggaactgaag
    16801 cagcagagtt gggccgactc gacggagcgg gaggcgccgg agtccccgtc gcgcccggcg
    16861 ccgccctcct tcacgaagcg gcggcccggg agcgtccccg ccccgctcac cggccgggag
    16921 gtggtcgatc tgatcaagcc ccggctggag gcgctgcgca cctcggccgc ggccaccagc
    16981 cgggaccgcc tgcgctccct cgaagtcgag gaactggtct acctgccggt cgggctggcg
    17041 cgggacgagg tggactacgg gccggacgtc atccgtgagc acctggaacg ggccgtcggc
    17101 gagggcgccg aggcccgccg ccacttcctg cgggtgcggg tcggtgcctg ggacgagcag
    17161 gtggcgatct gcctgttggt ccgcatccac acccagggcg ggatgctggt cctggaggtc
    17221 gccccgcacg tcctgacgcc ggtgcgcccg gagttcaagt cggtggacgt ggtcgcggcg
    17281 cacggcgggg acggcccgct gcgcgacgtg atcaggagcg tgctgaccag cccctcggcg
    17341 ggatgcgccg ccgcggtctc gctgtgccag acggcggtgt ccctgatgcg cacgtggctg
    17401 acgatgccgg aacacgccct gccggacgca ccggtcgcgt ccgtacggga gttggggagc
    17461 gtgccggaac tctcgctgtt ccaggagatg gacatcagcc ggtacgtgaa gacgctccag
    17521 gaccggatcg ccaacggggt gcaggaggcc ctgcgcaaca agggctacga aacgggcgtg
    17581 ttcgaccagt acatcatcaa cgtgggtgag ggcggggtgt tcatcggcgg gatgagcggc
    17641 ggtgcggtcg cctccggcga gcgcgccctg gccaagcaca cggacgcgtc gacggagacg
    17701 gggggcggtc ggggatgacg gttcaggagc cggagccggt gcacggccgg gaggtcggcg
    17761 acgacgggac ggacgccgcc ccgcccggcg acgcggcggc gggcggcaac cgggccggtg
    17821 gcggcatcag catcggcgta ctgaccggcg gcgcggtcgc ggccggggag cgggccgccg
    17881 ccgaggaccg ctcggtgcgc gacggccgct cggcaccggc gctcccgccc gcggacgggc
    17941 ccgaggcgcc cgccgtgccg acgagcgccg ccggcggcat cagcatcggc gtgatgaccg
    18001 gcggtgcggc ggccgcgggg gcggacgccc gggcgctgga cgcctcgacg caaccggcgc
    18061 tcgacgcgcc gcccgaactc cgggcggcac tgggcaccct gcgtcagcac ctgccgttgc
    18121 tcaccgcgac ggacgagacg tcggagatcg atgcccgact ggcggacgcc gaagaggaga
    18181 tcgacgacac cgggcgggtg cgtcgggacc gcctgcagtg gctgcgcgac cgcctcgacc
    18241 tcggcgcgac ggccgtggcg gggctcgcct cggcgacggc ggtcgtccag cagatcaccc
    18301 aactcctcgg cggccagggc taggaggtgc cggcatggac cagtgggacg aggaaaagca
    18361 ggactggctg gagccggcgc gaccggtcgg tgggccgccc gacggcaggt cccggcgcat
    18421 gctcatcgtg acgggctccg cggtcgtgct cgtcgcggcg gccgtggtcg ggctgtggca
    18481 actggcgcgc gacggccaac cggactcccc ggggtggagc ggcgccccgc cctccgcgcc
    18541 cggcggcggt tggtcgagca gtcccggcgg cggatcggtc gcctcgccgg gttcggacgg
    18601 tctggccgcg gctcccgacc cgtgcgcggc actcgacgcg aacacggccg cggcctgggg
    18661 cctgtccgcg ggccgcccga acaaccccag cgatccgcag gccgggctga aggcgtgcag
    18721 ttggagcgga accgtaggcg gcgccgccct cacctacacg ctgatctacg ccaaggacat
    18781 cccggtgtcg ccggaaccca cgccgaccag cgtcaccgga gttccgtccg cgtcggtgct
    18841 cgggaacgac caggggtgcg cgatcgtctg gcccacctcg ttcgggaagg tgttcgtgca
    18901 cgtcaaggcg gacaccggga cgcaaccgaa cctgtgcgac tccgccgcca ccttcgccac
    18961 ccaggttgcc ccgagggtgc cgtcctgacg gcccctcgca cgccggaggc cgtggccgcc
    19021 gctccgggca ggtattcgag gcggtcccgt gccggtgaat tcgcccgcgc ggcgaaggat
    19081 ccgggcgccg gtcggggaat tctcgtctgg catcgaaccg tccggacagc cggatggatc
    19141 gcgatcggga ggtcggtcat gacacacctg tccccgttcc gccgcggcgc cgccgtactc
    19201 gcctgcgccg ggttcctctg cggtgtcctc ggcaccggca cggccgccgc cgcaagtccc
    19261 gcggcggcca ccgcgggtgg cggcctcggc ccgtccaagg gccgcgtgat cgccaagaac
    19321 ggcctggagc tgcgggacgg ccccgggacc gcgtaccggg cggtgggctc gctgccgtac
    19381 ggcaccgtcg tcaccatccg ctgcaaggtc aacggcgaga acgtgcacgg caatccgcgc
    19441 tggtacgagg tcggggaggg ccgggtcacc tggttgtcgg cgcgctacgt cgagaccctc
    19501 ggcaccgcac cccgctggtg cgcggaccgg caccgctgat ccgactgcgc ggttccgtcc
    19561 cggccgcgtg cgggcgggac ggaaccgcgc cgctccgccc ggccggggca accgccgtgc
    19621 tccggagcgc ggttcaggcg gtctcggtgc gcacggcgat gagcgccacc gtcgcgtagc
    19681 ccatcgtgaa gctgccaccc cgcgcgtcga tggcggcccc gacgcccgcc agcacgtcgc
    19741 tcagcgcggc cggcgggatg cgggtgaagg cccccagggt gggcatctgg tccagccagg
    19801 cgtccctggt gtaggtccgc tcccagtcgt ggcgccactg ttgcggctcg tcgaagccgc
    19861 ccgcgtcccg gatgccgtcg gcggcccggg cgcacacctg ccggtaggcg tcgagggcgc
    19921 ccttcgtcag cgcggtgacg tcgaacggcg cgtccggcag tgcccgccgg caggccccga
    19981 cgacggcgtc cgccacgtcg tcggggaacc ggaagacgtt ccagaacggc gccaggaggc
    20041 cgccggggcg cagggcccgt gcggcccgct cggcgccggc gacggggtcg atccagtgcc
    20101 aggcggtgcc ggcgaccacg gcgtcgaagg cgcggtcggc ggggtcccag tcctcgaacc
    20161 gcgcgacgtc cacctccgtg ccgagtgcgc gggccacgtc ggccatccgt gcgtccggtt
    20221 cgaccccgag cacccggcag ccggccgcgc ggaactgccg ggcggcgatg cccgttccgc
    20281 agccgacgtc gaggacctcg gggacgtcgg ggccggggag gccggccgcg atccgtcgca
    20341 cgagggcgtc ggggtagcgg ggccgggccc ggtcgtagcg tgcggcgtcg gtgccgaacg
    20401 actccgccac ctgccggtgt tgacgcgctt cggggagccc tgagggcggc atagtgggca
    20461 tgcgcccact atggtgggcg catgcccact cgtcaaccgg atgggaggat tgcgggatcc
    20521 gaccgaggga aggggcgcac ccgtgccgac aggagtggcc atccgcgatg tgcgggagca
    20581 gctgttcggc gccgccgagc ggatcctgct gcaagccggg ccgaacgcgc tgaccagccg
    20641 cgcggtcacc acggaggcgg gctgcgccaa gggcgtcctg caccggcact tcgccgactt
    20701 cgacgccttc ctcgccgagt tggtgcggga ccggatcggt cggatcgagg accaggccac
    20761 cgcgctgcgc gcggccgccg ggaccggcgc cgtcgccgac cgcctcaccg ccgcgctgct
    20821 cgacgtgttc gggccggtcg ccgtggcgat cgtctcgctc gtgatctccc gcgacggcct
    20881 gcgcgcccaa ctgcgagccg gcggttcgac cggcgtcccg ctcctcgccg aggccaccgc
    20941 aatgctggcc tcgtacctga ccgccgagcg cgcactgggc cgggtcgccg cggacgccga
    21001 cgtcgacgtc ctcgcgccca ccctgatcgg cgccggccac ctgctgttcg cggaccggga
    21061 gggcaccacg ccggacgcgc cggccgttca ccgggtcgtg accgcggtca tcgccggagt
    21121 ggtgcgcgaa ccgtgacgcg ggcccggcgg agggtgccgt agcgcctggg cgggggctcg
    21181 gggccggacg gtcagcgccc gcgcgcccgc gacatcacag ggggcgcttg aggtgcgcgg
    21241 tgaggagttg ccgccaaccg tccctggcct gcgcccactc gtcggggcag ccctcggctc
    21301 gctccgcgtc gagccgggcg tcgctcccga cgaggtcctc gtgccgatcc gggtgcgcac
    21361 cgtagacgta gcaggcgtag ttcgccgcgc gctgaccgtc gaggctgtgc tcgtcgcgca
    21421 ggtcggtcgc gtccaacggg gtctcctcgg cggccagggc gtagtcgtcc gccgcggcgc
    21481 gggccttgcg ttcgcccgcc cggccctggc cgatcagcag caccgcggcg aactggtcgg
    21541 ccacgtcctc ctcccggccg gtgaagcgca ggccgaggcg gtcgatcagg gcgtgggcgc
    21601 cctcgtggta ggcggtctcc tccagcacgg cggccacatg ggcgtcggcc gccgccgtgc
    21661 cgccgggtcg gtcggggccc gggccggcct gccggaagcg ctcgcgtatc tcgtcgacgt
    21721 gctcggtgca gaagtcgatg gtgccggtct ccgggtcgta ggcgggttcg gccgcaccgc
    21781 acgagcggac cacgaacggg atgggctgcg gcaccttgag ggtggcgttc aaccggtcgg
    21841 ccgccgcgtc caggatgcgg tgcgcgcgga ggtagccggt ggcggtcgcc gcccggccgc
    21901 cggtgcggta ctgcacgacg aagccgttcg agccgccctt gccgtggctc cggcggcccg
    21961 cgccgtccgt cggctcggcc gcgtcccgcc cggccgtgca gccggtcacc gcggccgcca
    22021 gggccaaggc cagcaacgcc cgtgtggtgt gccccgtcca gcggcccatc cgcctgctcc
    22081 tcacttgcct gggccgcgca ccgcggcggt ccgtccgagc tgggaagagg cgtgtgcgga
    22141 gctggcggtt ccacgccggc ggcggatcgg acgggaatca ccacagcgcg tcgatgttcc
    22201 cggggtgcag cgcaatgcgg ctgtcgcgga acgcggcccg ggcctgccgg gcgcgcggcg
    22261 agaagaagtc cgccatggtg accttgtcga acccgggccg gtcgctgggg aagggcgcct
    22321 gcggggttcc gccgacgagg acggtgcccg ggaggtggtg ccagccggcg ctctcgtaga
    22381 aggcgcgcaa cggtcggtcg caggtgaaca accccacgtc gtaacccccg gtggccagcg
    22441 cctcccgagc cgcggtcacc agccgccggc cgtgcccccg gccgcgcgcc tccaggcgcg
    22501 tcacgaccgt gctcaggcca ccggcggtgt agtcgcagcc ggcgtgccgg atctccttgg
    22561 cgaggacgtc cagcgcggcg aggacggtcc cgtcgtcgac cagcagcatc gaccgcggcc
    22621 gcagcgcggg gtcgtggacc ggctcggtgg gcccgggggc cgtgcccctc cccgacggcc
    22681 acgcctgttc ctggagctcc cgcacctggg tccggagttc ggcgggggtg gcggcttcgg
    22741 ggaacgcgag gatctgcacc cgccgattgt gtaccagcgg ggtgcgggcg gcacaacgga
    22801 tcgtcccggg tgacccgggc cggcccgccg gcgaggggcc ggcggccgct cgggcccgcg
    22861 cgtgtccgtc cgcggcgggg ccggacgtcc gggaaaggat gcgggcatgt ccgccgtcct
    22921 ccacgcgctg tccctcaccg gctcgatgac ctgggagatc acctgggcgc tgatcctggg
    22981 cttcggcctg tccgcggtgg tccaggcggt ggtccgcaag tccaccgtgg tcgcggcgct
    23041 cggtgacgac cgcccgcgca ccctggcact cgccgccggg ctgggtgcgg cctcgtcctc
    23101 gtgctcctac gccgcggtgg cgctggcccg ttcactgttc cgcaaggggg cggacttcac
    23161 cgccgcgatg gcgttccaga tcgcctccac caatctggtc gtggaactgg ggatcatcct
    23221 ggcgctgctg atggggtggc agttcaccgc cgccgagttc gtgggcgggc cggtcatgat
    23281 cgtggtgctg gcgttgctgc tgcgggcctt cctgacgccg gcgttgctgc gcgcggcccg
    23341 ggcgcaggcc gaccgcggcg tggcaggttc gatggagggg cacgccgcga tggacatgtc
    23401 cgtccggcgc gacggctcct tcctgcgccg gctgtgctcg cccgagggcg tcacggccac
    23461 cgcgcacgtc ttcgtcatgg agtgggcggc gatcctgcgg gacctgatgg ccggtctgct
    23521 cgtcgccggt gccatcgcgg cgtgggtgcc cgacgccttc tggcggtcct tcttcttcga
    23581 cggccatccg ctcgccgcca agttctgggg gccgctcgtc ggtcccctgg tcgcgatggc
    23641 gtcgttcgtc tgctccatcg gcaacgtgcc gctcgcggtg gtgttgtgga agggcgggat
    23701 cagcttcggc ggggtggtgg cgttcgtctt cgcggacctg ctgatcctgc cgatcctcgg
    23761 catctaccgg aagtactacg gccccaggat ggcgctgctg ctgctcggca ccttctacgt
    23821 cgcgagcgcg gtcgccgggt gcgtggtcga gttcgtcttc ggcgggctcg gcctcgtccc
    23881 ggaccaggcc cgggcgcgga tcccgcagga gggcgtcacc ctgaactaca ccacctggct
    23941 caacgtggcc ttcctcgccc tggccgcggc cctgttggtg cggttcttcc gcaccggtgg
    24001 ccgggagatg ctccgcacga tgggcggcgc ccccgccggt gggcgcgacg acgggcacgg
    24061 ggacccagcg ggtcggcgcg gcccgtgaca gggcgtttca ccggccgctc gtcgtgcgcg
    24121 ccgtcgggcc cgtcgcaccg gcggccggta ccgctccgac cgacggtgcg tcaggggcac
    24181 ggccaccgcc gtgacgctcc cgagccgaag cccacctgaa gctacctgaa gagcccttca
    24241 ggaacgttct ggcagtctga cgtcatgcgc ttgttgatcg tggaggacga aaaacgcctc
    24301 gccaccaccc tggccaaggg gctggcggcg gagggcttcg ccgtggacgt ggcacacgac
    24361 ggccgggagg gtctgcacct ggccaccacc cagggctacg acctgctcat cctggacatc
    24421 atgctgcccg ggatgaacgg ctaccgcgtc tgcgcggccc tgcgcgcggc cggtgacgaa
    24481 accgcgatcc tcatgctgac cgccaaggac ggcgagtacg acgaggcgga ggggctggac
    24541 accggcgccg acgactacct caccaagccg ttctcctacg tggtcctgct ggcccgcgtc
    24601 cgggcgctgc tgcgccgccg gacgcgcggc ggcagccccg tcctgcgcct cggtgacctg
    24661 gtggtggacc cgaacgggca ccgttgcgcc cgcggcgagg aggagatccc gctcaccgcc
    24721 aaggagttcg cggtgctgga gtacctggcg tcgcgatccg gacatgtcgt ctccaaagca
    24781 gagatactgg agcacgtctg ggacttcgcc tacgacggcg acccgaacat catcgaggtc
    24841 tacatcagcg ccctgcgacg gaagatcgac gccccgttcg gccggcgctc gatcaccacc
    24901 gtgcgcggcg ccggttaccg gctggcggcc gaccgtggct gagcagaccg ccgcggcgcc
    24961 gtcgcagccg cgtcagcccc gctggtgggg gtccgtccgg gcccgcacca ccttggcctc
    25021 caccctggtg gtggcgctgg ccctggtcgc cgccggggcc gcggtcctct gggtgctcca
    25081 gcgcaacctc gtcgacagcg ccggcctcca ggcggaggtg gtcgcccgcg aggtcgccac
    25141 ccaggtcgcg gtcggcacgc ccttcgacca cctcaacatg cccgacgagg acgaccggcc
    25201 ggtgcaggtg gtcgacgccg accgcaaggt gctggccgcc ggcgacgacc tccaccacgc
    25261 cccgccgctg gccgacttcg cccgcgcgcc gcaccggccg gacggccacg acgaccacga
    25321 cgacgatgac gacgacaccc ctgcgcgagg ctccgccagc gagcacgccg cgttccgcac
    25381 ggtcacgttg aagctgcacg acgaccactc cgaccaggac ttccaggtcg ccg
//
