LOCUS       NZ_CP102975            24231 bp    DNA     circular CON 10-JUL-2024
DEFINITION  Staphylococcus aureus strain 16CS0209 chromosome, complete genome.
ACCESSION   NZ_CP102975
VERSION     NZ_CP102975.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 2769676)
  AUTHORS   Monecke,S., Roberts,M.C., Braun,S.D., Diezel,C., Muller,E.,
            Reinicke,M., Linde,J., Joshi,P.R., Paudel,S., Acharya,M.,
            Chalise,M.K., Fessler,A.T., Hotzel,H., Khanal,L., Koju,N.P.,
            Schwarz,S., Kyes,R.C. and Ehricht,R.
  TITLE     Sequence Analysis of Novel Staphylococcus aureus Lineages from Wild
            and Captive Macaques
  JOURNAL   Int J Mol Sci 23 (19), 11225 (2022)
   PUBMED   36232529
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2769676)
  AUTHORS   Braun,S.D., Diezel,C., Reinicke,M., Linde,J. and Monecke,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2022) Optisch-Molekulare Diagnostik und
            Systemtechnologien, Leibniz Institute of Photonic Technology (IPHT),
            Philosophenweg 7, Jena 07743, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. v2.8.3-b1695
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 181x
            Sequencing Technology             :: Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024741735.1-RS_2024_07_10
            Annotation Date                   :: 07/10/2024 04:01:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,704
            CDSs (total)                      :: 2,622
            Genes (coding)                    :: 2,539
            CDSs (with protein)               :: 2,539
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 40 of 83
            Pseudo Genes (incomplete)         :: 40 of 83
            Pseudo Genes (internal stop)      :: 17 of 83
            Pseudo Genes (multiple problems)  :: 14 of 83
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:15:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1867531
            Orig. end                         :: 1891762
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102975.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24231
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="6"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24231
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24231
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14231](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14231)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(107..118)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     gene            complement(724..1440)
                     /locus_tag="NW953_RS08950"
                     /old_locus_tag="NW953_08950"
     CDS             complement(724..1440)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034984.1"
                     /locus_tag="NW953_RS08950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08950"
                     /product="serine protease"
                     /protein_id="WP_258409234.1"
                     /transl_table=11
                     /translation="MNKNIIIKSIAALTILTSVTGVGTTMVEGIQQTAKAEHNVKQVQN
                     TNISPYKGIVRIGSATGFVVGKNTILTNKHVLPGVQVGSTILAHPNGENDTGGYYKVKK
                     IIPYAGSEDLAIVQVEEDSVYPKNKKFSENTEVLKFASGAQVNDRLSIVGYPNPYKNKH
                     HMFESTGKILSIDGNQMTSDAFAEGGNSGSPVFNSNHEVIAIAYAVDVKNDATKKSYLV
                     YFTPEIKKFIADNTEK"
     gene            complement(1564..2283)
                     /locus_tag="NW953_RS08955"
                     /old_locus_tag="NW953_08955"
     CDS             complement(1564..2283)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500440.1"
                     /locus_tag="NW953_RS08955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08955"
                     /product="serine protease"
                     /protein_id="WP_258409235.1"
                     /transl_table=11
                     /translation="MNKNLVIKSIAALVILTSVTGISAAVVEETQQIAKAEKHVTQVKD
                     TNVFPYHGIVAFKDATGFVIGKNTIITNKHVSKDYKVGDRITAHPNGDKGNGGIYKIKS
                     ISDYPGNEDISVMNIEEQAVERGSNGFNFNDNVQAFKFAKDAKVDDKIKVIGYPLPAQN
                     SFKQFESTGTIKRIKENILNFDAYIEPGNSGSPVLNSNNEVIGVVYGGIGKIGSEYNGA
                     VYFTPQIKDFIQKHIEQ"
     gene            complement(2341..3063)
                     /locus_tag="NW953_RS08960"
                     /old_locus_tag="NW953_08960"
     CDS             complement(2341..3063)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500441.1"
                     /locus_tag="NW953_RS08960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08960"
                     /product="serine protease"
                     /protein_id="WP_123097096.1"
                     /transl_table=11
                     /translation="MNKNVVIKSIAALTILTSVTGVGTTLVEGVQQTAKAENNVTKVKD
                     TSIFPYTGVVLVNSATGFVVGKNTILTNKHVSKYYKPGDRISAHPNGDKANGGIYSIKK
                     IIDYPGKEDVSIIQVEERAVERGPKGFNFNDNVTPFKYAAGAKAGDRIKVIGYPQPHKN
                     KYILHESTGPVMSVEGSSIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKDDDNRNAY
                     GVYFTPEIKKFIAENIDK"
     misc_feature    complement(3125..3136)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            complement(3183..3890)
                     /locus_tag="NW953_RS08965"
                     /old_locus_tag="NW953_08965"
     CDS             complement(3183..3890)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500442.1"
                     /locus_tag="NW953_RS08965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08965"
                     /product="serine protease"
                     /protein_id="WP_258409236.1"
                     /transl_table=11
                     /translation="MNKNVMIKGLTALTILTSLGFAEKISDQPHSIAKAEKNIKEITDA
                     TTPPYNSVVAFAGGTGVVVGKNTIVTNKHIAKSDDIFKIRVSAHHSSKGKGGGNYDVKD
                     VVEYPGKEDLAIVHVHEISTEGLNFNKNVSYAKFADSAKAKDRISVIGYPKGAQTKYKM
                     FESTGTINHINGTFMEFDAYAQPGNSGSPVLNSKNELLGILYAGSGKDESEKNFGVYFT
                     SQLKEFIQNNIEK"
     misc_feature    complement(4822..4833)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.09"
                     /tool="antismash"
     gene            4858..5439
                     /locus_tag="NW953_RS08970"
                     /old_locus_tag="NW953_08970"
     CDS             4858..5439
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001092764.1"
                     /locus_tag="NW953_RS08970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08970"
                     /product="DUF4888 domain-containing protein"
                     /protein_id="WP_258409237.1"
                     /transl_table=11
                     /translation="MNTKFLGKTLVASALVLTTLGTGLHSSYLGLDTNKVVKTAKAEEN
                     MTDGQLWKKVKDSLIDSDIISGNRDEEIKVTYSLKDGNSPSVTAPGNDSGDNFNQKIDF
                     GSLKQVDISKQNIGEEDFNKRLDANKTWNTFTQKLKDAGLLKNGQKVTIQATNPTTSST
                     NSITGTVGETLNDKNADPLEKRFINKITIE"
     gene            complement(5916..6614)
                     /locus_tag="NW953_RS08975"
                     /old_locus_tag="NW953_08975"
     CDS             complement(5916..6614)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500445.1"
                     /locus_tag="NW953_RS08975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08975"
                     /product="BsaG protein"
                     /protein_id="WP_258409238.1"
                     /transl_table=11
                     /translation="MIINELKSCKLKFSKQALTFVPIIVTILFILFINWYLNVNEWNGR
                     QISLFTASFNAITSLLISINVYQVINFEENIGHFNHILGKAKRLNWLNASMIFTYTITA
                     ICILLASINLLWHSHDMKITLMFIGVSLFFNVIILLLLFIFSIFIKDVMAIVAGILMFI
                     FNVYFGLEVLGDHSWFYLPITYATRYVYMIIEGSIPVTLTLAIYIIITLLLAVLLFKGF
                     NKWSGRTIKD"
     gene            complement(6611..7372)
                     /locus_tag="NW953_RS08980"
                     /old_locus_tag="NW953_08980"
     CDS             complement(6611..7372)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500446.1"
                     /locus_tag="NW953_RS08980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08980"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_258409239.1"
                     /transl_table=11
                     /translation="MIHLKIEGIKFKNSFSMYVLLISPLVFLCFAIFTVLFAKSNSGTA
                     NSVSPYITLLFNIWPIAFIPIVLCMACNSLFKIEMRNKSFNYYLSNNWSITKEIRAKIA
                     ILSLAFLVHCFLVYMIAYIGELIINPHPINAMLLLVTILLMYVVSLPLIPLNFLLTRYF
                     GVFVSILINLVLSVICVIFLTLKSLFWVLPWAIMQRIPLVTLGILPNGLVVNHNSKYFN
                     DLNALYISIIISIILFAILTFLNNKKSWRLK"
     gene            complement(7369..8061)
                     /locus_tag="NW953_RS08985"
                     /old_locus_tag="NW953_08985"
     CDS             complement(7369..8061)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500447.1"
                     /locus_tag="NW953_RS08985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08985"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding subunit"
                     /protein_id="WP_001096793.1"
                     /transl_table=11
                     /translation="MAKLVTENISKRFKNQDVLKHINITLENNEVYGLLGINGAGKTTL
                     MKIICGILQQDSGEILLDNQPMKRNDLHKVGSLIETPATYNHLSAQDNLKIVCLNESVD
                     FSEIKNVLSLVNLNVDKKKKVKDFSLGMKQRLGIAMALIKKPEILVLDEPSNGLDPYGI
                     QELRELLKLLTEQGTSIIISSHILSEIQVLADHIGIIHEGELKYQQRNNKDENLEDIFF
                     KITKGDYK"
     gene            complement(8084..9457)
                     /locus_tag="NW953_RS08990"
                     /old_locus_tag="NW953_08990"
     CDS             complement(8084..9457)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849073.1"
                     /locus_tag="NW953_RS08990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08990"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_258409240.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.5e-43, bitscore:
                     146.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTIKCVFNNLIILSLLISFTMSTASASEEQYYSVEYKNTATFNK
                     LVKQNALNVVYNIPELNVAQIKMTKTHANAIANYKNDIKYINATCSTCITSEKTIDRTS
                     NESLFSRQWDMNKITNNGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVP
                     LNGFRGTEPEETGDVLDVNDRKGHGTMVSGQTSANGRLIGVAPNNKFTMYRVFGSKKTE
                     LLWVSKAIVQAANDGNQVINISVGSYTILDKNDHQTFRKDEKVEYDALQKAINYAKKKK
                     SIVVAAAGNDGIDVNDKQKLNLQREYRGNGEVKDVPASMDNVVTVGSTDQNSNLSEFSN
                     FGMNYTDIVAPGGSFAYLNQFGEDKWMNEGYMQKENILTTANNGRYIYQAGTSLATPKV
                     SGALALIIDKYHLEKQPDKAIELLYQHGTSKNNKPLSRYGYGELDVYKALNVTNQKAS"
     gene            complement(9467..9985)
                     /locus_tag="NW953_RS08995"
                     /old_locus_tag="NW953_08995"
     CDS             complement(9467..9985)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500449.1"
                     /locus_tag="NW953_RS08995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_08995"
                     /product="phosphopantothenate--cysteine ligase family
                     flavoprotein"
                     /protein_id="WP_258409241.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.1e-28, bitscore:
                     96.1, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGENVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFIN
                     GEILKQFCDNYYDEFENPFLNHVDIANKHDKIIILPATSNTINKLANGICDNLLLTICH
                     TAFEKLSIFPNMNLRMWENPVTQNNIRLLKDYGVSIYPANISESYELASKTFKKNVVAP
                     EPYKVLEFI"
     gene            complement(10001..11245)
                     /locus_tag="NW953_RS09000"
                     /old_locus_tag="NW953_09000"
     CDS             complement(10001..11245)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500450.1"
                     /locus_tag="NW953_RS09000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09000"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_258409242.1"
                     /sec_met_domain="LANC_like (E-value: 1.4e-80, bitscore:
                     268.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLNLILKKKFQEISEVDDFISKASTETDYFEPVTLSHGIPGLI
                     LFLDAYQKAYNTNTEQIVHKYIMKLAPYLQKQQYNHSLFGGLSGIAFSMDIASQNGRNY
                     QNILNNIDEVIVNEIENKMNQILQEPLNPLNYDTISGLAGIGRYLLNRVDANATNVKAL
                     KRILTYFKDIQYSQNSWVVPQESQFLESDKNYFTEGNINFGLAHGVLGPMSLFALCVIK
                     GITIENHQHILKDMYQFIMDEKFCCNNRWLQRYDLISERNRFNYIRNGWCYGNTGVMTT
                     LFLIGQALQDDEIIQMSKKVMLQVVNDQERNLISSTICHGLSSQILMLTIMNLHFELND
                     VSDYINELIDKLMSHYKGDHLVNFIDINENHEGVFKSEKVGLLEGEIGVYLTLMTLQNT
                     NILNEKNWTNAFLIS"
     gene            complement(11238..14231)
                     /locus_tag="NW953_RS09005"
                     /old_locus_tag="NW953_09005"
     CDS             complement(11238..14231)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500451.1"
                     /locus_tag="NW953_RS09005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09005"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_258409243.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.1e-152,
                     bitscore: 504.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.3e-12,
                     bitscore: 45.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.2e-24, bitscore:
                     82.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTIYEPSSICMIRTPLLSVEFFKLFLNSEQIKYSDLQLNAQMNE
                     SILTTTFNLYRTLQDINFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINLGHFVN
                     EPTRLKVGNSIQKYVKVDGEWLYKLISYIESNDEYYQNLKVIWNSKAHIINDRIYLNEQ
                     SAIYLNNNKDTSFSIKNSELLVFIKNTVTNNNITFSNLAEKINQEFEIHDISKVKVYIH
                     NLVSKEIIYSTIRPPLSNSDNLNYILNKLSLHNDDFVEKIREIQKLISAYEKTEIGFGE
                     KLYKDIVQHMKALFKCKNYLQIDTKIDMINNQLHQNIATNISEAAYLLWLLSRNNIGFT
                     DLKVLHNSFIEKYGFEQLVNVKDLLSDITGFGTSIYNEVKGDENNIVMLKQKFLHALRN
                     NEEIVIDDKDVESLVNDNTINNYHAPMSTDVYAELYIGDYYNQYNELIVISPLTVSLNA
                     GATFGRFHHLIDTETLAKLEHEKAHYYQKSMHDDNVEFVSINNVPKYPRNHNVLTNHDS
                     YEYSMNLGSSYSDSKYELNLDDIYVGATFNKLYLYSRQLNKRVLFESNNMYNFLKESNL
                     YRLLREISMESVKCIEPMNDVSIDLFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEW
                     DQQFLKYQEQFNIPNIVNLVYGDNKLLLNLSLANHRYLLMKEYKKHKRVRLVESFLPQS
                     KNDHVYEIVTPIYKKSSYRGPEIEIPKYKNTDIEYDKEWFAIHIYIEKSSQDRFIIDNL
                     YPFVKHLKEKGDIDQYFLMRYIKQGDILKLRLYRNDENYNEIYSILKDWLSFVRQTTEV
                     SDYEFVSYEPEFFRYGGKNTIDEIESFFEYDTNLAVNIIDNDFKFDRPFVVAISIMYLF
                     EMLSISNEERMEIVNNYVPTSYKSKEIRPYKNELVTICNPENNFENIAKHYSDIYRILK
                     DDNQILSKLNERLKQPLTTKRSRIIGSLIHMRCNRIFGVDKDQETFVLSIVKEIVKTQK
                     YWCGDKND"
     aSDomain        complement(13521..13799)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NW953_RS09005_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.40E-14"
                     /identifier="RREFam001.1"
                     /label="NW953_RS09005"
                     /locus_tag="NW953_RS09005"
                     /protein_end="237"
                     /protein_start="144"
                     /score="45.5"
                     /tool="antismash"
                     /translation="VIWNSKAHIINDRIYLNEQSAIYLNNNKDTSFSIKNSELLVFIKN
                     TVTNNNITFSNLAEKINQEFEIHDISKVKVYIHNLVSKEIIYSTIRPP"
     gene            complement(14296..14439)
                     /locus_tag="NW953_RS09010"
                     /old_locus_tag="NW953_09010"
     CDS             complement(14296..14439)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500452.1"
                     /locus_tag="NW953_RS09010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09010"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_070005024.1"
                     /sec_met_domain="TIGR03731 (E-value: 4.8e-22, bitscore:
                     75.0, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 8.1e-09, bitscore:
                     32.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVLDLDVQVKANNNSNDSAGDERITSFIGCTPGCGKTGSFNSF
                     CC"
     CDS_motif       complement(14368..14439)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKVLDLDVQVKANNNSNDSAGDE"
                     /locus_tag="NW953_RS09010_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14296..14367)
                     /prepeptide="core"
                     /locus_tag="NW953_RS09010_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="3.40"
                     /molecular_weight="2232.6"
                     /monoisotopic_mass="2231.0"
                     /core_sequence="RITSFIGCTPGCGKTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKVLDLDVQVKANNNSNDSAGDE"
                     /leader_location="[14367:14439](-)"
                     /alternative_weights="2250.6"
                     /alternative_weights="2268.7"
     gene            complement(15175..15318)
                     /locus_tag="NW953_RS09015"
                     /old_locus_tag="NW953_09015"
     CDS             complement(15175..15318)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500452.1"
                     /locus_tag="NW953_RS09015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09015"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_000416759.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.5e-20, bitscore:
                     70.2, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 2e-07, bitscore: 28.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVLDLDVQVKGNNNTNDSAGDERITSHLFCSFGCEKTGSFNSF
                     CC"
     CDS_motif       complement(15247..15318)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKVLDLDVQVKGNNNTNDSAGDE"
                     /locus_tag="NW953_RS09015_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15175..15246)
                     /prepeptide="core"
                     /locus_tag="NW953_RS09015_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="0.40"
                     /molecular_weight="2420.8"
                     /monoisotopic_mass="2419.1"
                     /core_sequence="RITSHLFCSFGCEKTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKVLDLDVQVKGNNNTNDSAGDE"
                     /leader_location="[15246:15318](-)"
                     /alternative_weights="2438.8"
                     /alternative_weights="2456.9"
     misc_feature    complement(15403..15416)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.88"
                     /tool="antismash"
     misc_feature    15416..15433
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.94"
                     /tool="antismash"
     gene            complement(15741..16724)
                     /locus_tag="NW953_RS09020"
                     /old_locus_tag="NW953_09020"
     CDS             complement(15741..16724)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500453.1"
                     /locus_tag="NW953_RS09020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09020"
                     /product="leukocidin/hemolysin toxin family protein"
                     /protein_id="WP_258409244.1"
                     /transl_table=11
                     /translation="MKMKKLIKSSVATSVALIMLSNTVDAAQHITPVSEKKVDDKITLY
                     KTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLKAAGNINSGYKKPNPNDYHYSYFYW
                     GAKYNVSVSSESNDSVNVVDYAPKNQNEEFQVQQTLGYSYGGDINITNGLSGGLNGSKS
                     FSETINYKQESYRTTIDRKTSHKKIGWGVEAHKIMNNGWGPYGRDSYDSTYGNEMFLGG
                     RQSSSNAGQNFLPTHQMPLLARGNFNPEFISVLSHKQNDDKKSKIKVTYQREMDRYTNY
                     WNRLHWIGNNYKNQNTVTFTSTYEVDWQNHTVKLVDTYSKETAPGV"
     gene            complement(16726..17661)
                     /gene="lukE"
                     /locus_tag="NW953_RS09025"
                     /old_locus_tag="NW953_09025"
     CDS             complement(16726..17661)
                     /codon_start=1
                     /gene="lukE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_114304764.1"
                     /locus_tag="NW953_RS09025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09025"
                     /product="bi-component leukocidin LukED subunit E"
                     /protein_id="WP_258409245.1"
                     /transl_table=11
                     /translation="MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRT
                     EDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQGFINSRTSFSDVKGSGYELTKRMIW
                     PFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSK
                     TISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPSGSAREY
                     FAPDNQLPPLVQSGFNPSFITTVSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAE
                     RKHNAFVNRNFVVRYEVNWKTHEIKVKGHN"
     misc_feature    18525..18540
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.54"
                     /tool="antismash"
     gene            19297..19893
                     /locus_tag="NW953_RS09030"
                     /old_locus_tag="NW953_09030"
     CDS             19297..19893
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595639.1"
                     /locus_tag="NW953_RS09030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09030"
                     /product="hypothetical protein"
                     /protein_id="WP_258409246.1"
                     /transl_table=11
                     /translation="MVKQVLRKSLDTVKEHIDKSNFQKNLIFSLVIFPFLFVPYIIIDI
                     LVHLSNNQEYFKLLSSISHIFLMFFVTAISLYAILSIPLTSNSCRKSSFRKISKVIIYF
                     LVFFYILSHHINIDISKMDSSWHFYALFLCFFIISYKLTEKIMKVCKWIFNEESNNDEG
                     LRTQKLFFITTVVFGTISIFSTIANVLVAIKQFLN"
     gene            20061..21407
                     /locus_tag="NW953_RS09035"
                     /old_locus_tag="NW953_09035"
     CDS             20061..21407
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711492.1"
                     /locus_tag="NW953_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09035"
                     /product="DUF4041 domain-containing protein"
                     /protein_id="WP_258409247.1"
                     /transl_table=11
                     /translation="MKKEILKKQWVLWTILVTSFFSIGTPGIAIIPFSLSIYALSKLIL
                     VNKFVEPDLVTLQNLKEKNKSINIENQKIKREIQELKNLKKDLISSIEEGTKELEHITS
                     YLNDELFKYDIELTYPFDLVEVDSSQINTYIKKLQMKEKELLNLEEVKIFNVYTENKRH
                     QNAQAKQIIRLFNAETSQLINKVNSKNIESMQNKIFKSYEGINKIFETDNVRIPETLLD
                     IKLEMLDLMHKYQVKIEDEKIIRREERARLKEIEQAEKEMEKKLKELDKDIRHHNNEIK
                     KLTMYLNNTDLQVEKELYIEKIRELDQSLKNLNSERENVEDRKDNAQSGFVYIISNIGS
                     FGENVYKIGVTRRLEPMDRINELSSASVPFEFDVHALIFSEKAFELENKLHEYFKKYKV
                     NKVNGRKEFFKVNINEIKDKVLSEHNSTVQFIDEPKAIQYRETLRLTSL"
     misc_feature    21519..21532
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 25.44"
                     /tool="antismash"
     misc_feature    complement(21598..21613)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     misc_feature    complement(21618..21634)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            21664..>21892
                     /locus_tag="NW953_RS09040"
                     /old_locus_tag="NW953_09040"
                     /pseudo=""
     CDS             21664..>21892
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000121211.1"
                     /locus_tag="NW953_RS09040"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NW953_09040"
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDNYLILTEHV"
     gene            21993..22229
                     /locus_tag="NW953_RS09045"
                     /old_locus_tag="NW953_09045"
     CDS             21993..22229
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617704.1"
                     /locus_tag="NW953_RS09045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09045"
                     /product="hypothetical protein"
                     /protein_id="WP_258409248.1"
                     /transl_table=11
                     /translation="MIRFDVNGSDHANSPNNERIPTPHIHIYTEEYNNGGIAIPLKDIE
                     DLELTDEIIESLDFFIKYTNIKHDNIIIEPRLL"
     gene            22250..23026
                     /locus_tag="NW953_RS09050"
                     /old_locus_tag="NW953_09050"
     CDS             22250..23026
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001561168.1"
                     /locus_tag="NW953_RS09050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW953_09050"
                     /product="DUF1828 domain-containing protein"
                     /protein_id="WP_000848319.1"
                     /transl_table=11
                     /translation="MKTIEERMNEYFNWLKQNYIFKELDSSTEITTPFKNHLNDFIRIY
                     ADTLPNNEICLSDDGLTINELEMLGIDINTKTRTKLIQNILNQFNLKLVDKEITADVKN
                     ESFAQSKHNLIQGILKIYDLTLTTKSNVTNIFYEEVFEFLYDREIRGLAQVSVSGESGL
                     KYSIDYIVSETKSQPEKLVNFTNNLDFNKITNEAYIYRDIKPNRPSRNKLEPIMLIIVN
                     DVDHPINERAQTVAEHENLEILKWSNKSKIIETLTS"
     misc_feature    23233..23242
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 14.51"
                     /tool="antismash"
     misc_feature    complement(23543..23558)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.94"
                     /tool="antismash"
     misc_feature    23544..23557
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 23.81"
                     /tool="antismash"
     misc_feature    24136..24150
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 23.46"
                     /tool="antismash"
ORIGIN
        1 aagcatcaga aataatcatg ttgcctttca ctgatagcac ttttcctgtt gattcataca
       61 tttgaaattt atttatataa ggttctggat agccaacaat tgaaatgcgt tcattttctt
      121 tggcttctga tgctattttt aaaatacctg tataatcttt aaaattccta ttttttggat
      181 gaacagcttt atcttccaca tgtagaatgg caatatcttc tttacctgca taacggacaa
      241 tttttttaac tttataaaaa ccgccattat tatattcacc attaggatgc gcaataatat
      301 gtgcgccaat ttccatacct gcaacgacat gcttgttagt aacaattgta ttttttccga
      361 caatgaaacc tgttccagat cctatcgaaa cgataccatt gtatggtgct acattagtat
      421 ttttgattag tttcacatta tgttcggctt tggctgtttg ttgaatacct tcaaccattg
      481 ttgtgccaac accagtcact gatgttaaaa tcgtcaatgc tgctatactt ttgatgatta
      541 tatttttatt catttttgtg ctcctctaag tattcttatt aatataatgt tagttttttg
      601 aagttttatt ttttaaaatc atttcgaata aatagaatca cagagatatg atttgaattg
      661 ttgagtttgt tgtttatttt aaaaaaatta tttatcaatg taaggatgga tttgtatgtt
      721 cgtttatttt tctgtgttat ctgcaatgaa tttcttgatc tcgggtgtga aataaactaa
      781 atatgatttt tttgttgcat catttttgac atcgacagca tatgcaattg caatgacctc
      841 atgatttgaa ttaaacactg gggatcctga attgccacct tcagcaaatg catctgaagt
      901 catttgatta ccatcgatgg ataatatctt tcctgttgat tcaaacatat gatgcttatt
      961 tttatatgga ttagggtaac caacgattga taaacgatca tttacttgag cgccactcgc
     1021 aaatttaagg acttcagtat tttcactgaa ttttttattt tttggataaa cagaatcttc
     1081 ttcaacttga actattgcta aatcttcaga tcctgcgtat ggaatgattt tttttacttt
     1141 atagtatcca ccggtatcat tttcgccatt tggatgagca agaattgtgc taccaacttg
     1201 aacaccaggt aatacatgct tatttgttaa aattgtattt tttcctacca caaatcctgt
     1261 agctgatcca attctaacaa ttcctttata cggagaaata tttgtgtttt gtacttgctt
     1321 cacattatgt tcggcttttg ctgtttgttg aatcccttca accattgttg tgccaacgcc
     1381 agtcactgat gttaatatcg tcaatgccgc aatacttttg atgattatat ttttattcat
     1441 ttttgtgctc ctctgtttat tcatgatgct tttgatatag acgtttgttt tttatgttat
     1501 attcgacgat gtttttcgtt taaatcattg aactacatgt tctcggtgtg tatttaaaca
     1561 tgtttattgt tcaatgtgct tttgaataaa atctttaatt tgaggcgtaa aatatacagc
     1621 accattgtat tcagaaccaa tttttccaat accgccatat acaacaccta tgacttcatt
     1681 gttagaattt agaacgggtg atcctgaatt accaggttcg atatatgcat caaaatttaa
     1741 aatattctct ttaattcgtt ttatagttcc tgtagattca aattgtttaa aactgttttg
     1801 tgcaggtaac gggtaaccga taactttaat tttgtcatca actttagcat ctttcgcaaa
     1861 tttaaatgct tgaacattat cattaaaatt aaagccattg gatccacgtt caaccgcttg
     1921 ttcttctata ttcatgacgg aaatatcttc attaccagga taatcggaaa tacttttaat
     1981 tttataaata ccaccatttc ctttgtcacc atttggatga gcagtaattc tatcgccaac
     2041 tttataatcc tttgatacat gtttattggt gataattgta tttttaccga ttacaaagcc
     2101 tgtcgcatct ttaaatgcaa cgatgccatg atacggaaaa acatttgtat ctttaacttg
     2161 cgtaacatgc ttctctgctt ttgctatttg ttgtgtctct tcaacgactg cagcacttat
     2221 tccagttact gatgttaaaa tgactaatgc tgcgatgctt ttaatgacta aatttttatt
     2281 cattttcaag ctcctttaca atttgagata tattgcaacg ctcgttttaa aacaatttga
     2341 ttatttatct atattttctg caatgaattt tttaatctct ggtgtgaagt agacgccata
     2401 agcatttcta ttgtcatcat ctttcacatc tgaagcaaaa tgaataccta ctagttcgtt
     2461 gttgctattt aatacaggtg aaccagagtt tccactttct gtatgcgcag aatatacaat
     2521 gctgctacct tctactgaca tcacagggcc tgttgactca tgtaaaatat atttattttt
     2581 atgtggttgt gggtaaccga taactttaat tcggtcacca gctttagcgc ctgccgcata
     2641 tttaaaaggt gttacattat cgttaaaatt aaaacctttt ggaccacgtt ctactgcacg
     2701 ttcttcaact tgaataatcg atacatcttc tttacctgga taatcaataa tctttttaat
     2761 tgaataaata ccaccattgg ccttgtcacc attagggtga gcagatatac gatcaccagg
     2821 tttgtaatat tttgatacat gtttatttgt taaaatagtg ttttttccaa ctacaaatcc
     2881 agtcgcacta ttaactaaaa caacacctgt atatgggaat atactcgtat ctttaacttt
     2941 tgtgacatta ttttctgctt tcgctgtttg ttgaactccc tcaaccaatg ttgttccgac
     3001 acctgttaca gaagttaata ttgtcaatgc tgctatactt ttgatgacta cgtttttgtt
     3061 cattttaagt tcctcttttt ttatttattt tgatatctag atacataatc ttttagttaa
     3121 ttatgtaacc gttttcttta tttcttttta aaaaatcaac ttcttgaata aaatgttgat
     3181 acttattttt caatattatt ttgaataaat tcttttaatt gtgatgtgaa atagacaccg
     3241 aaattctttt cagattcatc ttttccactt cctgcatata aaataccaag cagttcattt
     3301 ttagaattca atacaggaga tcctgaatta cctggttgtg catacgcatc aaattccata
     3361 aatgttccat tgatatgatt aatcgttcct gtcgattcaa acattttata ttttgtttgt
     3421 gcaccctttg gataaccaat aacagaaatt ctatctttcg cttttgcgct atcagcgaac
     3481 tttgcataac taacattctt gttaaaattc aaaccttcag tactaatttc atggacatga
     3541 acaatcgcaa gatcttcttt tccaggatat tctacaacat ctttaacgtc gtagttaccg
     3601 ccacctttac ctttactcga atgatgtgct gatactctaa ttttgaaaat atcatcactt
     3661 ttagcgatat gtttgttagt tacgattgta ttcttaccaa caactacacc agtaccacct
     3721 gcaaaggcga ctacagaatt atatggtggt gtagttgcat cagtaatttc tttgatattc
     3781 ttttctgcct tggcaattga atgaggttga tcagaaattt tttcagcaaa accaagagat
     3841 gttaaaatag ttagagctgt taaaccttta atcattacat ttttattcat atattacctc
     3901 ctttaatatt tatttttata gttaatgtat ctagatacac atttactata tacagtttat
     3961 ataaaattat taattaaata ttaattaact acttattaac gttttattaa ataataaaat
     4021 atgaattgac tcatttgttt aaatatggtt aaaactcaat atcacacaat taaaattagc
     4081 tttttatgaa ttttttagcc tcaaatatta attataagac tgaaatcata atatttattc
     4141 ggaaattggg atagtgggat tttttgtcta aatagtgaac atggcttatg tttatgttca
     4201 cggtctatat gatgcattga atttagtaat ttaattgatg atagatgtct cctgatttta
     4261 tgacaatttg agagctggaa ttgaatcatg tgtatataag taaatgagga aattgtaatg
     4321 tagtgtggct tgttgaaagt gatagaatta tggaattttc ttcgagttat ggtacttcgt
     4381 ggaatatatt ttgaggtttt gatttggtta gtgtcatcga tatatgcgga tacttatttc
     4441 aggtttaatt taatttcata gttaagatga tatgtatgag gttcgttgac atgtttatgc
     4501 atgtcttttt ttacttacgg caaattatca gatgttttct taatatcaaa ctttatggta
     4561 atcaccaatt ttaaaacatt atttgagact ttcttttcta attgattata aatttccagc
     4621 tataaacttg ctaaatattt acttactgat caaaatactc accaacaatc tttcatttaa
     4681 aacacttttt ctttaatttt tataattcaa aacaccaaaa cgatgttaaa aaattattct
     4741 attttttagt taatagatag ttaatacatt tttgatattt agttaattgt tcttttaaaa
     4801 aattattatt atatttgcat tgtaaacgtt tacaatataa aaaaaggagc aattaaaatg
     4861 aatacaaaat ttttaggtaa aacattagta gcaagtgctt tagtattaac aacattagga
     4921 acaggcttac attcttcata cttaggatta gatacaaata aagttgttaa aacagctaaa
     4981 gcagaagaaa atatgacaga cggtcaattg tggaaaaaag ttaaagattc tttaattgat
     5041 tcagatatta ttagcggtaa ccgagatgaa gaaataaaag taacttattc acttaaagat
     5101 ggtaattcgc ctagtgtgac tgcacctgga aatgatagcg gcgataattt taatcaaaaa
     5161 attgattttg gcagtttaaa acaagttgat ataagtaaac aaaatattgg tgaagaagat
     5221 tttaacaaaa gattagatgc gaataaaact tggaacactt ttactcaaaa attaaaggat
     5281 gctggtttat tgaaaaatgg tcaaaaagta accattcaag ctactaatcc aacaacatct
     5341 tcgacaaaca gtattaccgg cacagtaggt gaaacattga atgataaaaa tgctgatcca
     5401 ttagaaaaac gcttcataaa caaaatcaca atcgaataat cgctaaactc aaatttcctt
     5461 aattcataaa accttaataa ctaacccttt cttacaaacc acctagccca taataaatta
     5521 aaacgtcatt ttttatttca aatagcggaa aataaaaaaa ccattccgca ttaactttgg
     5581 caagttggaa tggttaaaaa atatttttag aagccagcgt ttggcttact aagacgacat
     5641 gttcgcgcat gtcgtcttat ttttacatct atataataac acgcaattca ataaaatgtc
     5701 taaccaataa atcacaatta cattcaaact caaaaaaatt cacaccaatt gttcatcgtc
     5761 tattcaaagt ttacatttaa ttaatcagac ataatcaatc acgcctaata ccccttctga
     5821 ccgaatacaa aatcattttg tatttttaac ttatcaatgc ttttttctcc cttttcaacg
     5881 aatctaaatt tctcttacca tcagcgacct aatctttaat ctttaatagt tctgccgctc
     5941 catttattaa atcctttaaa gagtaaaact gctaatagca acgtgataat aatatagatc
     6001 gctaatgtta atgtaactgg tatacttcct tctataatca tataaacgta acgtgtagca
     6061 tatgtgattg gtaaatagaa ccacgaatga tctccaagca cttctaatcc aaaatagacg
     6121 ttaaaaataa acattaagat tccggcaaca atagccatta catctttaat aaaaatgcta
     6181 aaaataaaaa gtagcagtaa tataatgaca ttgaaaaaca atgatacgcc tataaacata
     6241 agtgttattt tcatatcatg tgaatgccac aataaattaa ttgatgctaa tagaatacat
     6301 atggctgtaa tagtataagt aaaaatcatt gatgcattta accaatttag ccttttagct
     6361 tttcctaaaa tatgattaaa gtgaccaata ttttcttcaa aattgattac ttgatagacg
     6421 tttatagaaa ttaatagtga tgtaattgca ttaaaactcg ctgtaaacaa gctaatttgt
     6481 cgaccattcc attcattcac gtttaaatac caattaataa ataatataaa tagtatggtt
     6541 acaataatag gtacaaatgt aagtgcttgc ttagaaaatt tcaacttaca tgactttaat
     6601 tcgttaatta tcattttaat ctccaacttt tcttattatt taaaaatgtt aatattgcga
     6661 aaagaatgat gcttataata atcgaaatat ataaggcatt gagatcatta aaatattttg
     6721 agttatgatt tacaactaaa ccattaggta atatgccaag cgttacaagc gggattctct
     6781 gcatgatcgc ccatggcaac acccaaaata aacttttcaa tgttaaaaat atgacacaaa
     6841 tgacagataa tactaagttt attaatattg atacgaacac cccaaagtat cgtgttaata
     6901 agaagttaag cggtattaat ggtagagata caacatacat caacaatatt gtcaccaata
     6961 gcaacatagc attaatcgga tgcggattaa taataagctc gcctatataa gcaatcatat
     7021 atactaaaaa gcaatgtacc aaaaatgcta atgataaaat ggcaatcttt gctcttattt
     7081 cttttgtaat tgaccaatta ttacttaagt aataattaaa tgatttattt ctcatttcaa
     7141 ttttaaataa tgaattacaa gccatacata atacaattgg aatgaatgca attggccaaa
     7201 tattaaatag taatgttata tatggtgaca cactattcgc tgttcctgaa ttacttttag
     7261 cgaataaaac tgtgaaaata gcaaaacata gaaataccag tggacttatt aataaaacat
     7321 acatactgaa agaattttta aatttgatac cttctatttt taaatgtatc atttgtaatc
     7381 tcctttcgtt attttgaaga atatgtcttc taagttttca tctttgttat ttctttgctg
     7441 gtattttagc tcaccttcat gaataatacc gatatgatct gctaaaactt gaatttcaga
     7501 taaaatatga cttgaaataa tgatactagt accttgttct gttaataatt ttagaagttc
     7561 tctaagttct tgtattccgt atgggtctag accattagat ggttcgtcta atactaagat
     7621 ttctggcttt ttaatcaatg ccattgcaat tccaagtctt tgtttcatac ctaaagaaaa
     7681 atccttaacc tttttctttt tatcgacatt taaattaact aaacttaaaa catttttaat
     7741 ttcactgaaa tctacacttt catttaaaca cacgattttt aaattatctt gtgcacttaa
     7801 atggttatac gtcgccggtg tttctataag tgaaccaact ttgtgtaaat cattgcgttt
     7861 catcggttga ttatctaaca atatctctcc agaatcttgt tgaagtatgc cacatataat
     7921 tttcataagt gtcgttttac cggctccatt aataccaagt aatccataaa cttcgttatt
     7981 ttctaaagtg atattaatat gctttaatac atcttgattt ttaaaccgct tcgaaatgtt
     8041 ttcagtaact aattttgcca taatcaaaaa ctcctttgat ttattaactt gctttttgat
     8101 ttgttacatt taatgcttta tacacatcaa gctcaccata tccataccta ctcaaaggtt
     8161 tattattctt agatgtccca tgctgatata acaactcaat cgctttatct ggttgttttt
     8221 caagatgata tttatcaatg attaaagcta gcgctcccga aactttaggt gtggctaatg
     8281 aagttccagc ttgataaata tatcttccgt tattggcagt agttaaaatg ttctcctttt
     8341 gcatataccc ttcattcatc catttatcct caccaaattg atttaaataa gcaaatgatc
     8401 ctcctggcgc aacaatatct gtataattca taccaaaatt ggaaaactca gatagattac
     8461 tattttgatc tgttgatcct actgtaacga cattatccat agatgcagga acatctttca
     8521 cttcgccatt accacgatat tcacgctgta aatttagttt ctgcttgtca ttgacatcaa
     8581 taccatcatt cccagctgca gctacaacga tagatttttt cttcttggcg taattgattg
     8641 ctttctgtag cgcatcatat tctacttttt catcttttct aaatgtttga tggtcatttt
     8701 tgtccaaaat agtataacta ccaacactaa tattaatgac ttgatttcca tcatttgcag
     8761 cttgaacaat cgcttttgat acccaaagca attctgtttt tttactacca aacacgcgat
     8821 acattgtaaa tttgttattc ggtgcaacac ctattaatct accattagca ctcgtttgac
     8881 ccgacaccat cgtgccatgt ccttttctat cattgacatc gagaacatca cctgtttctt
     8941 ccggttcagt acctctaaaa ccgtttaaag gtactaaatt tttagaatca gtcgagaaat
     9001 tatttttcaa atcgtcatgg tttttcatca cacctgtatc tatgattgct attttagtat
     9061 tagcatgttt tggcaaatca tcatacgatg caccattatt tgttatttta ttcatatccc
     9121 attgtcttga aaataatgac tcatttgatg ttctgtctat tgttttctca ctagtaatac
     9181 aagttgaaca tgtggcattg atatatttaa tgtcattttt atagtttgct attgcattag
     9241 catgcgtttt tgtcatttta atctgtgcca catttaattc cggtatatta tagacaacgt
     9301 ttaaggcatt ctgtttaact aacttgttaa atgttgctgt atttttgtat tcaacactgt
     9361 aatattgttc ttctgacgct gatgcagtac tcattgtaaa agaaattaaa agactcaata
     9421 ttattaaatt attaaacacg cactttatgg ttttcatctt cttatctcaa atgaattcca
     9481 gaactttata tggttctggt gcgacaacat tctttttaaa tgtttttgac gctaattcat
     9541 aactttctga aatatttgct gggtatattg atacaccata atcttttaat aatcgtatat
     9601 tattttgagt tactggattt tcccacatgc gtaaattcat atttggaaat attgagagtt
     9661 tttcaaaagc tgtatgacaa atagttagta ataaattgtc acatatacca tttgctaatt
     9721 tgttaatcgt attagatgtc gcaggtaaaa taataatctt gtcgtgctta tttgctatat
     9781 ctacatgatt taaaaaagga ttttcaaatt cgtcataata gttatcacaa aattgtttta
     9841 atatttcacc gttaataaac tttctaccat ttgttgatgc aattacattt acttcatcaa
     9901 attttgattt caattcaata atataatggc taatgttgat actatttact gagccacaca
     9961 aacaaatcaa tacattttcc cccatgatat acgcctccat tcagctaatt aaaaacgcat
    10021 ttgtccaatt tttttcattg agaatatttg tattttgcaa agtcatcaat gttagataaa
    10081 cccctatttc tccttctaaa agacctactt tttcactttt aaatacgcct tcatgattct
    10141 cattaatgtc tataaaattc accaagtgat ctcccttata atgagacatc agtttatcta
    10201 ttaattcatt tatataatca gaaacatcat ttaattcaaa atgcaaattc atgatagtta
    10261 acattaatat ttgcgaagat aatccatgac aaatagtaga actaattaaa tttctctcct
    10321 gatcatttac gacttgtaac atcacttttt tagacatttg aattatttca tcatcttgta
    10381 acgcttggcc gattaaaaat aatgtcgtca tcacacccgt attgccataa caccaaccat
    10441 tccgaatata attaaagcga ttacgttcag aaatcaaatc gtaacgctgc aaccatcgat
    10501 tattgcaaca aaatttttcg tccataataa attggtacat gtcttttaat atgtgctgat
    10561 gattttcaat cgtaattcct ttaatcacgc ataatgcaaa taaagacatc ggtcctagca
    10621 ctccatgtgc aaggccaaaa ttgatattac cttcagtaaa ataattttta tcagactcta
    10681 aaaattgact ttcttgtggg actacccagc tattttgaga atattgaatg tctttaaagt
    10741 atgttaatat tctttttaac gctttaacat ttgtggcgtt tgcgtctacc cgatttaata
    10801 aatatcgccc tatccccgct aaaccactga tagtgtcata atttaatgga tttaatggtt
    10861 cttgtaatat ttgattcatt ttattttcta tttcattcac aatgacttca tcaatattat
    10921 ttaaaatatt ttgataattc ctgccatttt gtgatgctat atccattgaa aatgcaattc
    10981 ctgaaagtcc accaaataga gaatgattat attgctgttt ttgtaagtat ggtgctaatt
    11041 tcatgatata tttatgcacg atttgttcag tatttgtgtt gtatgctttt tgataggcat
    11101 ctaaaaataa tattaaacct ggaatgccat gtgataatgt tactggttca aagtaatctg
    11161 tttcagttga tgcttttgaa ataaaatcat ctacttctga aatctcttga aactttttct
    11221 tcaaaattag attcaaatca gtcattttta tcaccacacc aatacttttg agttttaaca
    11281 atttctttta caatagataa tacaaatgtt tcttggtcct tatcaacgcc aaatattcga
    11341 ttgcagcgca tatgaattaa actgccaata atccttgacc tttttgtagt taaaggttgt
    11401 tttagtcttt catttaattt gctcaaaatt tggttgtcat cttttaaaat tcgataaata
    11461 tcactatagt gtttagcgat gttttcgaaa ttattttcag gattacatat agttacgagt
    11521 tcatttttat atggtctaat ctctttgctt ttatatgagg taggtacata gttattaaca
    11581 atttccatac gctcttcatt agaaattgac aacatttcaa ataaatacat tattgaaata
    11641 gcaacaacaa atggtcgatc aaacttaaaa tcattgtcaa taatattgac agctaaattc
    11701 gtatcatatt caaaaaagga ttctatttca tcaatcgtgt tcttaccgcc atatctaaaa
    11761 aattctggct catatgatac aaattcataa tctgaaacct ctgtcgtttg acgaacaaat
    11821 gataaccaat cttttaagat actgtatatt tcgttataat tttcgtcatt cctgtataac
    11881 ctcaacttta aaatgtcacc ttgtttgata tagcgcatta aaaaatattg atctatatct
    11941 cccttttctt taagatgttt tacaaatgga tacaaattat cgatgataaa tctatcttgt
    12001 gaagattttt cgatataaat gtgtattgca aaccattctt tgtcatattc aatatctgta
    12061 tttttatatt ttggaatttc aatctcgggt cctcgataag atgatttttt ataaattggt
    12121 gtaacaattt catacacatg atcattcttt gattgtggta aaaatgattc tactaaacgt
    12181 acacgtttat gcttcttata ttctttcatc aataaatatc tatgattagc taatgataaa
    12241 tttagtagaa gcttgttatc tccataaact aaattcacga tgttaggtat attgaattgt
    12301 tcttgatatt tcaaaaattg ttgatcccat tcttcatttt taggtaaagg taataccatc
    12361 tcattaattt tccaatatgc tggtttaaga atgacatttt tatatctgat tcgtggtgaa
    12421 taactaaata aatcaatact cacatcattc ataggttcaa tgcatttcac agattccatt
    12481 gaaatttctc gtaacaatcg atataaatta ctttctttta aaaagttata catattgttt
    12541 gattcaaata gtaccctttt attaagttgg cgagaatata aatataattt gttaaaggta
    12601 gcaccaacat aaatatcatc taagttaagc tcatactttg aatcactata actacttcct
    12661 aaattcattg aatattcgta tgagtcatga ttagttaata cattatgatt tcgcggatat
    12721 ttcggtacat tatttataga aacaaattct acattgtcat catgcatcga cttttgataa
    12781 taatgtgctt tttcatgttc taattttgct aaagtttcag tatcaattaa atgatgaaag
    12841 cgcccaaatg tagcgccagc atttaacgaa actgttaaag gactaataac aatgagctca
    12901 ttatactgat tgtagtagtc tccaatatat agttcagcgt atacatcggt gctcattggt
    12961 gcatgataat tattgatagt gttatcgtta accaatgact ctacatcttt atcatcgatc
    13021 acaatttctt cattatttct caaagcgtgt aagaattttt gctttagcat tacaatatta
    13081 ttttcgtcgc ctttaacttc attataaatc gatgttccaa atcctgtgat atccgaaagt
    13141 aaatctttaa cattaacaag ttgttcaaat ccatactttt caataaaact gttgtgaaga
    13201 actttcaaat ctgtgaatcc aatattattt cttgataaaa gccacaataa gtacgctgct
    13261 tcagatatat ttgttgctat attttggtgt aattgattgt taatcatgtc aattttggta
    13321 tcaatttgaa gataattttt acatttgaat aacgccttca tatgctgaac aatgtcttta
    13381 tataatttct caccaaatcc aatttctgtt ttttcataag ctgatatcaa tttctggatt
    13441 tctctaattt tttccacaaa atcatcatta tgtaaagaaa gtttatttaa aatataattt
    13501 aaattatcgc tatttgataa cggtggtctg attgttgaat atataatttc cttcgagaca
    13561 agattatgga tatatacttt cactttagaa atatcatgaa tttcaaattc ttgatttatt
    13621 ttttcagcta aatttgaaaa agtaatatta ttattcgtca cagtgttttt gataaatacg
    13681 agtaattcac tatttttaat ggaaaaagat gtgtctttat tgttattcaa ataaatagca
    13741 ctttgttcat ttaaatatat tcgatcattg ataatatgtg ctttactatt ccaaataact
    13801 ttcaaatttt gataatattc atcattactc tcaatatagc taatcagttt atacaaccat
    13861 tcaccatcaa ctttcacata cttttggata ctatttccaa ctttaagacg tgtgggttcg
    13921 tttacaaaat gccccaaatt aataccactt aataatccaa atggcgttgg acgtgttgac
    13981 attctaatta aatattttaa taaactctct ttagcatctc ttaccttctt gttatcgcca
    14041 tcaaaattta tatcttgtaa agtacgatat aagttaaatg ttgttgttag gattgattca
    14101 ttcatctgag catttaattg tagatcgcta tatttaattt gttcagaatt taaaaataac
    14161 ttgaaaaatt caactgataa taaaggtgtt ctaatcatac aaatacttga cggttcgtaa
    14221 atagtgttca tttgtaagca cctcacatat ttgaatagac aaatagagcc ctttcaggct
    14281 ctatttgctg taatcttaac agcagaagct attaaaacta ccagtcttac cacaaccagg
    14341 agtacaacca atgaaactag taatacgttc gtcacctgct gaatcatttg agttattgtt
    14401 tgctttaact tgcacgtcta aatcaagaac tttttccata gataaaacct cctattatta
    14461 gttgaagtta aggcctactt caattgtcat attatccctt ttcacacaac aaatcaataa
    14521 attatataat tatattttgt gaattttttg taaacactta ttaattttac aatattattt
    14581 tggtatttag acttttgtgt ttttacatta ctatttattt tcactaatag ttttgaatct
    14641 aagttcataa ttttaaattt attgatgtat ttttttatag atgaatcaat tcattcatac
    14701 aaatacttag atattcttag ctatcaatac tattatgaat ttggagatga ctgcttgaga
    14761 ttaattaata gatatttatg caattttgtt ctatttataa aaaatttagc aatgaataat
    14821 tgaagttatt ttaaagatga ggatattaac atataatttc aatgacttga ttattttctt
    14881 aaatgacatg ttctaagaga gtcaatataa taacaaaagc ttgttattac ttatatgtaa
    14941 agatagaggc taattacata atcctaactt atttaacagg aagtcatgaa aactatatta
    15001 caattaaaag tataactttc catcaccaaa gtaagaatgt attgaaacac tcaactgata
    15061 atataaaagg ctaattataa aaatacctga cgattagtaa actgtttccc tttttaacac
    15121 ctaatatatt taaaaagaca aatagagccc tttcaggctc tatttgctgt atccttaaca
    15181 acagaagctg ttaaaactac ccgtcttttc acaaccaaag ctacaaaaaa gatggctagt
    15241 tattctttcg tcacccgctg aatcattagt gttgttattt cctttaactt gcacgtctaa
    15301 atcaagaact ttttccatag ataaaacctc ctatttgaag ttgaagttaa ggcctacttc
    15361 aattgtcata ttatacatac tcaaacaaca aatcaacatg atttataata attatttgtt
    15421 attaatttgt aaattatcat taatttaatg gttctattat tattttttta ttgctaatta
    15481 tccctgctaa tcgatttgta tttaagttgt tatatcttta tattaggtca tttatatatt
    15541 tagagttaaa tctttttata tgttggaagt ttctaaataa ttctactttc gcaaatttag
    15601 caccctgata tttagcaaag ttatttacat tttccttact aaaaatcatc atgtatgtaa
    15661 ataaaaatta tgttagtttt ttaattccgt tagataattg aattaattcc acattgttaa
    15721 ttgtataagc atgtacagca ctatactccc ggagctgtct ctttagaata cgtatctact
    15781 aattttacag tatgattttg ccaatcaact tcataagttg atgtaaatgt tactgtattt
    15841 tgatttttat aattattacc tatccaatgt agtcgattcc aataattagt gtatctgtcc
    15901 atttctcttt gataagtaac tttgattttt gactttttat catcattttg cttatgagaa
    15961 agtacgctta taaattctgg attgaagtta ccacgtgcca ataacggcat ttgatgtgtt
    16021 ggtaagaaat tttgaccagc atttgaacta ctctgtctac cacctaaaaa catttcgttg
    16081 ccataagttg aatcataact atctctacca tatgggcccc agccattatt catgatttta
    16141 tgtgcctcga cgccccaacc tattttttta tgactcgttt ttctatcaat tgtagttcga
    16201 tagctttctt gtttataatt aattgtttct gaaaatgatt ttgagccatt caatccacca
    16261 gataatccat ttgttatatt aatatctccg ccatatgaat aacctaatgt ttgttggact
    16321 tgaaattctt cattttgatt tttgggtgca tagtcaacaa catttacaga atcattggac
    16381 tccgagctaa cagaaacatt atacttagct ccccaataaa aatatgaata gtgataatca
    16441 tttggatttg gctttttata cccagaatta atgttcccag ccgccttaag tactaatgta
    16501 tctttatcat aacttttatc tttgatgaaa ttaaaagtta aaatttgaga aatattcaat
    16561 ttatcattat cagatgttgc tgttgttttg tataaagtga ttttatcatc tacttttttc
    16621 tcgcttacag gtgtaatatg ttgagccgca tcaactgtat tcgataacat aatcaatgca
    16681 actgatgtag caactgatga tttgattaat tttttcattt tcatattaat tatgtccttt
    16741 cactttaatt tcgtgtgttt tccagttaac ttcatatcta actacaaagt ttctatttac
    16801 aaatgcatta tgctttcttt ctgcataaat accagttcta gggaataaag ttgcatatgt
    16861 aatatctaag tttctaccat atgaaatttc aaattcactc gtatcgcttg accctttttc
    16921 atgtgatact gtcgtgataa atgatggatt aaagccactt tgaactaatg gtggcaattg
    16981 attatcagga gcaaaatatt ctcttgctga acctgacgga ccatttggac tttgtacgaa
    17041 caaatatcta tcatgcgcag attttttacc atcaggcgta acaaattcgt ttgctttaac
    17101 accccattta acagattttg agttttgctt atctacttca ctgacataac tcttttgggt
    17161 ataactaatt gttttagaat aattaaatga gccattgcca cctatagatg gtgctgactg
    17221 gaaattacct ccaatgttat atcctaatgt ttgaccaaca tcagtagttt ctattttatt
    17281 tttaggaaga taattgatta agctaacatt tggatcttta gtcgtcagtc ctatattata
    17341 ttggaatggc caaatcattc gcttagttaa ttcatatcca ctacccttca catctgaaaa
    17401 tgaagttctg gaattgataa aaccttgcat tttaacaatt aaagcatctt tgttatattt
    17461 tttatctttt acaaagtcga attgaacatt ttgagtaacg ccccatttct tactacttac
    17521 atcctccgta cgtttgatta cttcagcacc atcaccaata ttctcaatat tagtattagc
    17581 tcttgattct tgaatcggag atgctaaagg cgcaatcagt cctactgaca aagttgcagc
    17641 taacattttt ttcttaaaca taagtttcac tttctttcta tataaatttt taatacaaat
    17701 ttattctaga ttatttcact tatttataaa attaactgtt cattaaaaaa taaaatacta
    17761 taaagtatta aaaatgacac aatttattca tttatgatgc tgaaaaccgg tcattttggc
    17821 gcaaccttca ttgtatttaa atagtttcct ttatattcga ccaatatgat aaaattgccg
    17881 acactcaact ttttctctat aaaaatcaaa actaacttta atcaaaactt taaaaataat
    17941 gtttgtttta ttacaaataa tctaaagttg aatttaaaat taactgatta ttaactattg
    18001 tccgttaaac ggaaatgatt acttcgtata gtgttataac ttaaatgttc tatatatcat
    18061 ttcgtaatat cgcttacttc atctaaaaaa atttaatgct atgatttagt ctaattaaaa
    18121 acatatatat atttactatg aactaaaatt tcaccctaaa aataaaaaac catgatttcg
    18181 aagtcttcat aaactgaagc tcctactctc atggcaattt atactatgat attcaattat
    18241 aatgcctagt ctcatagtaa acggctacta cattcgcatg tacttcgttt tactgtccac
    18301 gcacggtcgt tgacttattt atattataat atagatattt tatttttcaa tacttaattt
    18361 taaaaacttt ctactataaa atcattatga tattgaactt catctttaaa tccaatcata
    18421 ccttgcatga aaaacatatt tcaggaagct aatttaacaa tgtacacttt tggttgtgta
    18481 tgcatgtcac aattctccct atcatgacta ttattccata taattatgat attaattatc
    18541 gacttgtaaa gttatattct tacttgaaaa gttataaaca taagtgtcaa ataatgctaa
    18601 ttatggtaag ttaatattac atttagtaac atcaaagtta acaaatatag aagaaaatcc
    18661 tcaactttct aattatgaat cagaatatta tcttcttgaa aaaaatttaa ttaagacaca
    18721 atttatcaaa agtactaaaa gtagatgtct atatgaagaa accactaatc acaaattgac
    18781 gaatggagac atcttaaacc aacccggaaa tttgaaatta tggacgtagg caaggctttt
    18841 gaccaaccgt ttcattgcat gaatttggaa aaacatgtca gataccttta tgaaatttcc
    18901 gaatatttgc atttaagtaa atcataaatt tcagaagtat tatgataata tataccatta
    18961 aaaccaatta ctaattcatt gttctaatta tgcaggtaac tttccgcaat aagtccaaaa
    19021 taaatctaat ggataaaaaa taatcaaaac tttaacttta atcaatattg aactgcaaaa
    19081 atttggcaca agctaaaaca atgattaaac cgacagggat tgccaatgac acaggtaaat
    19141 cagtagaaga aatgatgtgt agaagttcac aagtaaactg gaaaatagca attaattaaa
    19201 attcgtttca acctttatac atactaagca aaattacaca ctttataaaa ataatattaa
    19261 ttttgtaaaa ttcagcttat ttggaggatt aaagcaatgg taaaacaggt tctaagaaaa
    19321 agtttagata cagtaaaaga acatatcgat aaaagtaact tccaaaaaaa cttaatattt
    19381 tcacttgtca tattcccatt cttatttgtg ccttacatta taatagatat actcgttcat
    19441 ttatctaata atcaagaata ctttaagtta ttatcatcta tttcacatat atttttaatg
    19501 ttctttgtaa cagcaataag tttatacgct atactttcta tacctttaac atctaattca
    19561 tgtaggaaat caagctttag aaagattagt aaagtaataa tttatttttt agtatttttt
    19621 tatatcctaa gccatcatat caatatagat atttctaaaa tggactcttc ttggcatttt
    19681 tatgcgcttt ttttatgttt ttttattatt tcatataaat taactgaaaa aataatgaag
    19741 gtatgcaaat ggatatttaa tgaagaatca aataacgatg aaggtttaag aactcaaaaa
    19801 ttatttttta taacgactgt ggtttttggt acaataagta tcttctcaac aattgcaaac
    19861 gttttagtag caataaaaca atttctaaat tagttatatc agctaaataa taaaaggcag
    19921 caaaaattat atagtaaaag cgatagtaga ttattaaaaa aaatatatag catttgttct
    19981 cacagcgtca aaactctaaa gcaattaagc catcgagagt atttaaatac atataaattc
    20041 aaattaagga gaataggtaa atgaaaaaag aaattttaaa aaagcaatgg gtattatgga
    20101 caatcttagt aacatctttc tttagtatag gcacaccagg tatagcaata atcccgttca
    20161 gtttatcaat atatgcatta tctaaattaa tacttgttaa taaatttgta gaacccgatt
    20221 tagtaacact tcaaaacttg aaagaaaaaa ataaaagtat caacattgaa aatcaaaaaa
    20281 tcaagcgtga aatacaagaa ttgaagaatc taaaaaaaga tttaatatct agtatagaag
    20341 aaggtactaa agaacttgaa cacattacta gttatttaaa tgatgaatta tttaaatatg
    20401 atatagaatt aacttatccc ttcgatttag ttgaagtaga ctcatctcaa attaatacat
    20461 atattaaaaa attacaaatg aaagaaaaag aattactaaa tcttgaagaa gtgaaaatat
    20521 ttaatgttta tacagagaat aagagacatc aaaatgcaca ggccaagcaa ataatacgat
    20581 tatttaatgc tgaaacttct caattaatta ataaagtaaa tagcaaaaat atcgaaagca
    20641 tgcagaacaa aatatttaaa agttatgaag ggataaataa aatatttgaa acggataatg
    20701 tacgtattcc tgaaacttta cttgacataa aacttgagat gttagattta atgcacaagt
    20761 atcaagttaa gatagaagat gaaaagatca taagaagaga agaacgagct agactgaaag
    20821 aaatagaaca agcagaaaaa gaaatggaga aaaaactaaa agagcttgat aaagacatta
    20881 gacaccacaa taatgaaatc aaaaagctga caatgtattt aaataacaca gatttacaag
    20941 tcgaaaaaga attatatatt gaaaagatta gagaattaga tcaatcactc aagaatttaa
    21001 attctgaaag agaaaatgta gaggacagaa aagataatgc tcaatcaggg tttgtttata
    21061 taatatcaaa tatcggttca tttggagaaa atgtttataa gattggtgta acccgtagat
    21121 tagaaccaat ggatagaatt aatgaattaa gtagcgcatc tgttcccttt gaattcgatg
    21181 tgcacgcttt aattttctct gaaaaagctt ttgagcttga aaacaaatta cacgaatact
    21241 ttaaaaaata taaagttaat aaagttaacg gaagaaaaga attctttaag gttaatatta
    21301 atgaaattaa agataaagtt ttatcagaac acaatagcac agttcaattc attgatgaac
    21361 caaaagctat acaatacaga gaaactttaa gattaacttc actctaaaaa tttgggtagc
    21421 ccgcctaccc ttattatttt tgccaacttt tatgagtatg tcatatatca ataaaaaaac
    21481 aaccaaattg taaaaggttt tatggttttg gatatgaata taattattgt aaaaagtaat
    21541 tatttattaa tcaatacatt gtaatattaa gtgcaaccca ataaaaattc ataaaaatac
    21601 ccacaatggg cactttattg taaggtgttt acaaccacga aaacacattt aagtattgcc
    21661 aatatgagcg ataactatct tatactaact gagcacgtat agagaaaatt attctttaag
    21721 acctattgca cgtaaattag accgatccgc atctactatc ttacgtgaaa ttagcagaaa
    21781 taatgtaaat aagttatatc aatctgaaac ggctcaaaag aattatgtaa ctacaagaaa
    21841 actttgtggt catcctactg gatttactcc agaacttagc aatatcatta agtaaaattt
    21901 aaaaatacca ctactcttct gaattaatcg tgattcgatt ttttaaaacc gattttcttt
    21961 tataaccaag tatttatgtt ttaaccactg atatgattag gttcgatgtt aatggtagcg
    22021 atcatgcaaa ttcaccaaat aatgaaagaa tacctacgcc acatatacac atatatactg
    22081 aagaatataa taatggtggt attgcgatcc cattaaaaga tattgaagat ttagaattaa
    22141 cagatgaaat tatagaatca ttagacttct ttataaagta tactaatata aaacacgata
    22201 atattataat agaaccaaga ttactctaaa agaaatggag ggatacttag tgaagactat
    22261 cgaagaaaga atgaacgaat atttcaactg gttaaaacaa aattatatct tcaaagaatt
    22321 agatagttct acagaaatta ctactccctt taagaaccat ttgaatgatt ttattagaat
    22381 atatgctgat acactaccta ataatgaaat ttgtctatca gatgacggat tgacgattaa
    22441 tgaattagaa atgttgggta ttgatataaa cacaaaaacg agaactaaac ttatacagaa
    22501 tattttaaat caatttaatt taaaattagt tgataaagaa attacagcgg atgttaaaaa
    22561 tgagagtttt gctcagtcta aacataattt aattcaaggc atattgaaaa tttatgacct
    22621 tactttaact actaaatcta acgttacaaa catattctat gaagaagtat ttgaattctt
    22681 atatgaccga gaaataagag gtttagcaca agtttctgtt tctggagaat caggtttaaa
    22741 atattctatt gattatattg tttcagaaac aaaatcacaa ccagaaaaac tagttaactt
    22801 tacaaataac ttagatttta acaaaataac taatgaagct tatatttacc gtgatatcaa
    22861 accaaacaga ccatccagaa acaaattaga acctatcatg ttaataattg taaatgatgt
    22921 agatcatccg ataaatgaaa gagcacaaac tgtagcagaa catgagaacc ttgagatatt
    22981 aaaatggtct aataaatcaa aaatcattga aactttaacc tcataaatta acattagacc
    23041 cctatttgta attctttaat tttcaaatca tatcgtgcaa gtaaaaaaat agatactttt
    23101 ttatttgcac gttttatttt agaacaaaaa gagcaaggtc aacgaatcag aaaatctttt
    23161 tcttgatacg tatttgacac tcgctctttt aagaatacta acattccatt gtattttcgt
    23221 taaattaacg gagaaggcgg attacctcga tagatttacc tctagagtgt taaaaaattg
    23281 tacattctta aacaatcaaa aatgtacgtt attaaattat catttccact ggagagtcat
    23341 gtcgactaaa agattataaa agtaaaaata catttaaagt cacgacaata ttaaaactct
    23401 taaaaacgtc attttcaaac cgccataaaa cagcattttt aaaccgctat ggacataaaa
    23461 tatatttaga ataaatcatt gagaaaaatt aaataattca accagcaata aactaactat
    23521 tttcatgaat ctataaaaca ctgagaacaa aagttcgaaa aacgcacttt atgattgtat
    23581 agtaatatca aatatactta tcagtgagta ttaagaaata cttccatttt aatactctta
    23641 gaatcaacta ctttattatc tccgtaaata tttaaaaact tatatggaac aaaagggact
    23701 agttcttttt taggaaataa gtcaaaccaa aaacttgtat tgttcttttc agtaaatttt
    23761 atatatccag attcaaatgc agaaccatca aactcgtata gatttttttc tttagtgagc
    23821 cagtgtcttg ctttgtagtc tagttcttga atagtaacca tattcttatt tgtagttatt
    23881 gtaaatccaa gtgattgtct attgtcgatt gttacctgta cagtaattaa tttatctctt
    23941 tcattttctg aactattaaa tgtaagacca ccatacatac aacaacctcc aaaattttgg
    24001 tttatatccg gttcagattt aggtattata catgtataaa aatatggaac accaaaaatg
    24061 tctacttttt tacctttata attgttagct aattctgtat tttctaattc agttttaacc
    24121 tcattataac tcttatactc aattggaaaa attaaatcat gagataaaaa ctgtctagaa
    24181 ttgctaactc ctcttccttc aacaggtgga gacatataaa gattcattac a
//
