LOCUS       NZ_CP102959            20705 bp    DNA     circular CON 09-JUL-2024
DEFINITION  Staphylococcus aureus strain 12-G-51 chromosome, complete genome.
ACCESSION   NZ_CP102959
VERSION     NZ_CP102959.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 2744047)
  AUTHORS   Monecke,S., Roberts,M.C., Braun,S.D., Diezel,C., Muller,E.,
            Reinicke,M., Linde,J., Joshi,P.R., Paudel,S., Acharya,M.,
            Chalise,M.K., Fessler,A.T., Hotzel,H., Khanal,L., Koju,N.P.,
            Schwarz,S., Kyes,R.C. and Ehricht,R.
  TITLE     Sequence Analysis of Novel Staphylococcus aureus Lineages from Wild
            and Captive Macaques
  JOURNAL   Int J Mol Sci 23 (19), 11225 (2022)
   PUBMED   36232529
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2744047)
  AUTHORS   Braun,S.D., Diezel,C., Reinicke,M., Linde,J. and Monecke,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2022) Optisch-Molekulare Diagnostik und
            Systemtechnologien, Leibniz Institute of Photonic Technology (IPHT),
            Philosophenweg 7, Jena 07743, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. v2.8.3-b1695
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 197x
            Sequencing Technology             :: Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024741495.1-RS_2024_07_09
            Annotation Date                   :: 07/09/2024 05:50:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,670
            CDSs (total)                      :: 2,588
            Genes (coding)                    :: 2,516
            CDSs (with protein)               :: 2,516
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 33 of 72
            Pseudo Genes (incomplete)         :: 43 of 72
            Pseudo Genes (internal stop)      :: 20 of 72
            Pseudo Genes (multiple problems)  :: 21 of 72
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:54:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2505993
            Orig. end                         :: 2526698
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102959.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20705
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="9"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20705
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20705
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10705](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10705
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            complement(550..1314)
                     /locus_tag="NW979_RS12215"
                     /old_locus_tag="NW979_12215"
     CDS             complement(550..1314)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501268.1"
                     /locus_tag="NW979_RS12215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12215"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_258413540.1"
                     /transl_table=11
                     /translation="MSNYSTGELAKLCNVTTRTIQYYDRKGILKPQGFTEGKRRVYTEQ
                     QRQTLELILLLKDLGCALSDIDMLLKGEGTLKTLNTLLTMKQQEINQQVKQQQAVLNKI
                     KNVQYYVNEASTSPITHLKDIEHVMSKSAEMKSIRRNIWISAGIIGIIQYSSIMSAILM
                     KNKWPFLIALPFMIGYGIGVTFYYQQKVAYLCPNCQHIFSPSLWQVIKAKHTATTRRFE
                     CPNCHETHYCIEVPKAHKSTEQLEISHIQHNN"
     misc_feature    complement(1268..1278)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            complement(1479..2171)
                     /locus_tag="NW979_RS12220"
                     /old_locus_tag="NW979_12220"
     CDS             complement(1479..2171)
                     /GO_process="GO:0015969 - guanosine tetraphosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501269.1"
                     /locus_tag="NW979_RS12220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12220"
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="WP_000289134.1"
                     /transl_table=11
                     /translation="MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIY
                     SSALKEISTKLSILDDNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEH
                     ILDIAGIRVVCNYLDDIYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVF
                     LAERVEVLPVEIQIRTIGMDMWASLEHKIRYKNKAETEKYRDLLKECATEITEVENKLQ
                     QIHSEITE"
     gene            complement(2402..2818)
                     /locus_tag="NW979_RS12225"
                     /old_locus_tag="NW979_12225"
     CDS             complement(2402..2818)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501270.1"
                     /locus_tag="NW979_RS12225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12225"
                     /product="DUF2188 domain-containing protein"
                     /protein_id="WP_001117047.1"
                     /transl_table=11
                     /translation="MPFTMKGYPEKWKDFEVIKRQKAIEIANAMLKEGYLEKDVVPIAA
                     KKAKDWYRALSKEEIKALEEENFVQFHTATMEKTEVDSEYATTDNEEHIQEQSNQDKSY
                     FDSESIGNQSGGVRQREPLMDGPHPKVVESFKDV"
     misc_feature    2924..2937
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.14"
                     /tool="antismash"
     gene            complement(2957..4780)
                     /locus_tag="NW979_RS12230"
                     /old_locus_tag="NW979_12230"
     CDS             complement(2957..4780)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000586397.1"
                     /locus_tag="NW979_RS12230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12230"
                     /product="FUSC family protein"
                     /protein_id="WP_072496694.1"
                     /transl_table=11
                     /translation="MIIPAIIGYLCGNFQFGLLVATGTLAHIYVFKGPSRSKLRTVIIC
                     NLAFAICMMLGTLTAKTPLVFGMTLLIVTVIPFYIFTALKIAGPSSTFFIVTFSLPINL
                     PIAPEEALYRGFAILVGGILATMMVLITIVFSKNKAEEQAIQNDFKLISKLLHTYNDKS
                     AFLQVAKTAVDSFKASDKLLITSTSSNDKLSRRFQKLLLLHTSAQGIYSELLELNAKQI
                     RPLPDELIEMMDHIIAQLDNSEENVRYWRKEVTVTEEFQNLFNHILKIDEMVHANEARI
                     AYEADMRKPLYSKRIYQNLTLDSIVFRNTLRYTAIMMIAIFIALMFDFEKAYWIPLSAH
                     TILLGTSTIHAIERGMARGLGTILGVLVLSVILLFSIPTPVAVILMGIAALFTEALVGA
                     NYAIAVVFITIQVILMNGLASQNLTINIAFPRVIDVAMGIVIAIIGLFVLGQRTASALL
                     PNVMAEVVRKEATLFHYLFSENQYKDDVYQKNTAMNLSVKLNNMTQVYNAANGELFSDK
                     TLIQNYYPSLFALEEISFMLNRAMANEDRLTINEQLMGEYLATFENIAKHLELNTELEI
                     KILPDLPQYNYIQSAMMNIQHNGFRERDKNV"
     gene            complement(5292..5495)
                     /locus_tag="NW979_RS12235"
                     /old_locus_tag="NW979_12235"
     CDS             complement(5292..5495)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001621913.1"
                     /locus_tag="NW979_RS12235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12235"
                     /product="hypothetical protein"
                     /protein_id="WP_001670187.1"
                     /transl_table=11
                     /translation="MKENLEKYIRSLPLIGLIISIFLISLFFLIYRVEGNFCVIILYCL
                     LPLFVNTSLYILYVSIFRYFKK"
     misc_feature    complement(5589..5598)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 15.51"
                     /tool="antismash"
     gene            complement(5690..6967)
                     /locus_tag="NW979_RS12240"
                     /old_locus_tag="NW979_12240"
     CDS             complement(5690..6967)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002463344.1"
                     /locus_tag="NW979_RS12240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12240"
                     /product="MFS transporter"
                     /protein_id="WP_000660709.1"
                     /transl_table=11
                     /translation="MKEKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTK
                     PQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYL
                     VRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFN
                     WQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPPWND
                     FFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLLMFFLILS
                     AGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGI
                     SMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPA
                     VIAVIMWFYVKPDQPLIVSDDKAIEK"
     misc_feature    7102..7113
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     misc_feature    complement(7302..7318)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.2"
                     /tool="antismash"
     misc_feature    7406..7419
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.24"
                     /tool="antismash"
     gene            7514..8125
                     /locus_tag="NW979_RS12245"
                     /old_locus_tag="NW979_12245"
     CDS             7514..8125
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501274.1"
                     /locus_tag="NW979_RS12245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12245"
                     /product="DedA family protein"
                     /protein_id="WP_000435044.1"
                     /transl_table=11
                     /translation="MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVK
                     SHLSILTLFIIATIASFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDW
                     FKKYGVWAVFICRFIPVLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLS
                     DSFGMLMTGLHTYSRIMYVVIIIAVIYFAIRYIGKRKRVK"
     gene            complement(8134..8232)
                     /locus_tag="NW979_RS12250"
                     /old_locus_tag="NW979_12250"
     CDS             complement(8134..8232)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501275.1"
                     /locus_tag="NW979_RS12250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12250"
                     /product="hypothetical protein"
                     /protein_id="WP_031774931.1"
                     /transl_table=11
                     /translation="MPNKLKKAVNHFNRWNDSLLFVYRNLKFMPLY"
     gene            complement(8222..9385)
                     /locus_tag="NW979_RS12255"
                     /old_locus_tag="NW979_12255"
     CDS             complement(8222..9385)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501276.1"
                     /locus_tag="NW979_RS12255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12255"
                     /product="MFS transporter"
                     /protein_id="WP_258413541.1"
                     /transl_table=11
                     /translation="MTNSNIRLYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINA
                     TVGGFIFIVAVMQIVLGRSIDSCDSKKVLLTGLGIVIISSFICAMTHNFILFAISRLFQ
                     AIGCGIIPLVTLTLLAKLSTDNGRAQAMANYQIFLSCAPALAPILGSTLGARWDYIGIF
                     SFLLVISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFS
                     ILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRLSKNYNEIMILRVTITGFA
                     IFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLSTIISKRFEHIKGKVLGVFNFVRY
                     IGMTVGALLIGIISHSLVPFYFTTITSMLIIIFLYIKIGDFQLKHAK"
     gene            complement(9378..9836)
                     /locus_tag="NW979_RS12260"
                     /old_locus_tag="NW979_12260"
     CDS             complement(9378..9836)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501277.1"
                     /locus_tag="NW979_RS12260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12260"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_258411152.1"
                     /transl_table=11
                     /translation="MKREVILKLQQFIIERENADKRRQYKKENEELDLSLTQFHIIELI
                     DNNDKVNNKFLSEMLNVSKPAITKSIKKLLAKDLVVESHNEFNKREVNYSLTQKGKKLS
                     YIHDELHEKAVKKYEEVLKVFDNDEMAVIVEFLNRSIEELKKEDGLND"
     gene            10001..10705
                     /locus_tag="NW979_RS12265"
                     /old_locus_tag="NW979_12265"
     CDS             10001..10705
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002492512.1"
                     /locus_tag="NW979_RS12265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12265"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_258413542.1"
                     /sec_met_domain="CDPS (E-value: 1e-58, bitscore: 195.8,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDFEISFLTENCKKIYQRKKHVTLGISPFTSKYNELYIKKIIQW
                     ANLNFEEFSILLAGNESKNLLECLGYSSSKANQKVRKEIKRQIRFCEDAILKCNKTITN
                     RIHRFSDFKQHISYIELYQQIVNQFNTDSNFRSCCLKMSLKALQSKKENLNKPVLITDE
                     SLEYAAQYVLAELPFFLNANPIINTQETILAYHAPWKLGTDIINNKFNLKMDKNQGYII
                     LTEKGDNYVKSL"
     gene            10689..11888
                     /locus_tag="NW979_RS12270"
                     /old_locus_tag="NW979_12270"
     CDS             10689..11888
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0046148 - pigment biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276927.1"
                     /locus_tag="NW979_RS12270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12270"
                     /product="cytochrome P450, cyclodipeptide
                     synthase-associated"
                     /protein_id="WP_258413161.1"
                     /sec_met_domain="p450 (E-value: 2.8e-40, bitscore: 135.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKVYNSIFDQAYEIDPIPYFNFLRKHDPVHYEESIDAYFVSKYK
                     DVKYILKNNDIFNTKTLAKRAEPVMKDRVLAQMSGQEHKSKKKAILKGMTGKYLENLMP
                     ILEKRTNDIINKHIEKKEIDIVNDFGKVFAVQSSMDLLGINLENYEKIREWHNGIAKFI
                     TSFNLNDEEIKYSLECSDKLENYLMPLIKDRKKSTKDDLISILLEYKNDDNSISDTEIL
                     ALSLNVLLAATEPVDKTLAYLFYNLLKNPEQFESVKNNPKLIKNAIIETLRYNSPVQLI
                     PRQVSKPFIFNNTELQAGDTVICMIGSANRDPEAYSNPDEFNIHRSSDNKSPFTSHSQN
                     LSFGTGVHTCVGASFSLIQLEMVAILLLKRLKNIKLKTMEITEHGIYTRGPKSMVISFD
                     "
     gene            complement(12127..>12464)
                     /locus_tag="NW979_RS13360"
                     /pseudo=""
     CDS             complement(12127..>12464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020219999.1"
                     /locus_tag="NW979_RS13360"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="group II intron maturase-specific
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RNLKRNLKWLTKRSRLGVHSTIL"
     gene            complement(<12507..>12776)
                     /locus_tag="NW979_RS12275"
                     /old_locus_tag="NW979_12275"
                     /pseudo=""
     CDS             complement(<12507..12776)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002494449.1"
                     /locus_tag="NW979_RS12275"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="NW979_12275"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFR"
     gene            13158..13853
                     /locus_tag="NW979_RS12280"
                     /old_locus_tag="NW979_12280"
     CDS             13158..13853
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501278.1"
                     /locus_tag="NW979_RS12280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12280"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_258413543.1"
                     /transl_table=11
                     /translation="MDVLTIEHLTKKIGNKTILEDVSFKLKRGQIVGLVGANGAGKTTL
                     MKVILGYSSFQSGNFNVINSKDSKNNIGALIENPGIYPFMSGYENLRLLNESKNTQDID
                     KIVSQLHMDEYIHKKAKTYSLGMKQKLGIAIAFLNEPQFIILDEPMNGLDPKAVRDVRE
                     LIVHKAQEGVTFLISSHILSELVKITNSILIINKGKIVTETSEEELKQFKDNDLENVLL
                     EIIEREDQA"
     gene            13855..14625
                     /locus_tag="NW979_RS12285"
                     /old_locus_tag="NW979_12285"
     CDS             13855..14625
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501279.1"
                     /locus_tag="NW979_RS12285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12285"
                     /product="ABC transporter permease"
                     /protein_id="WP_000536961.1"
                     /transl_table=11
                     /translation="MGTLIKQECFKLFKKKSTFIAPIVFILLMVAQGYIATKYNEIFTP
                     QESFTSAYNGFSWFAFLLIIQASTIISMEFHYGTIKNLLYREYSRTTMIVSKIITLFII
                     SLIYFVITIIASIVIGSLFFNDLNIFESSGNQLSLLNQLLLVSLGTFVGVWLVLSLTLL
                     LSSATNSTGVAIAVGIVFYFASSILAVIQTALLEKIDWLKWNPINMMNIMLQTVEKGFS
                     KSTKLELHELFIGNIAYISIFLILVVFIFKKKNI"
     misc_feature    14673..14687
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 24.73"
                     /tool="antismash"
     misc_feature    complement(14918..14929)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.68"
                     /tool="antismash"
     misc_feature    complement(14960..14973)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.63"
                     /tool="antismash"
     gene            14999..16963
                     /locus_tag="NW979_RS12290"
                     /old_locus_tag="NW979_12290"
     CDS             14999..16963
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501280.1"
                     /locus_tag="NW979_RS12290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12290"
                     /product="fructose-1,6-bisphosphatase"
                     /protein_id="WP_258413544.1"
                     /transl_table=11
                     /translation="MTQITEKELKKKYLDLLSQNFDTPEKLATEIINLESILELPKGTE
                     HFVSDLHGEYEAFQHVLRNGSGNVRAKINDIFKDKLSTKELNDLTALVYYPEDKLQLIK
                     CDFQNYGQLNVWYITTIEHLIQLIKYCSSKYTRSKLRRALPEQYVFIVEELLYKNNEFK
                     NKKSYYETLVNQVIELKQADDLIIGLAYSVQRLVVDHLHVVGDIYDRGPQPDKIMDTLI
                     NYHSLDIQWGNHDVLWVGAYAGSKVCLANLLRICARYDNLDIVEDAYGINLRPLLTLAE
                     KYYDADNPAFKPKKRPDKHERLTQREESQITKIHQAIAMIQFKLEIPVIKRRPNFEMDE
                     RLVLEKVNYDTNEITVYGKTYPLKDTCFQTINRDNPAELLPEEEEVMNKLLLSFQQSEK
                     LRRHMSFLMRKGSLYLPCNGNLLIHGCIPVDENGEMESFEIDGQTYSGQELLDVFEYHV
                     RKSFDEKENTDDLSTDLVWYLWTGKYSSLFGKRAMTTFERYFIADKASHKEEKNPYYHL
                     REDVNMVRKMLSDFGLNPDEGRIINGHTPVKEINGEDPIKADGKMLVIDGGFSKAYQST
                     TGIAGYTLLYNSFGMQLVAHQQFNAKEKILSEGIDELSIKRIVDKELQRKKIRNTNKGK
                     ELQAQIDILKMLMHDRYLD"
     misc_feature    complement(17124..17141)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.4"
                     /tool="antismash"
     misc_feature    complement(17248..17265)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 20.02"
                     /tool="antismash"
     gene            17307..18386
                     /locus_tag="NW979_RS12295"
                     /old_locus_tag="NW979_12295"
     CDS             17307..18386
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001566820.1"
                     /locus_tag="NW979_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12295"
                     /product="membrane protein"
                     /protein_id="WP_001621912.1"
                     /transl_table=11
                     /translation="MRILKESIIVAFAFVGVVVGAGFATGQEIFQFFTSHGAYSISGII
                     VTGLLITLGGMIVMHTGHHLKSRNHSDSINYFLYPSIARGFDIILTMFMLSLAIIMTAG
                     GASTIHQSFNLPYWLSALILVAFILATLFLKFDRLIAVLGGVTPFLIAIVIMIAVYYFT
                     TSHLDFTAANNDAQIHKQKSLSPGWWFDAINYASLQIAAAFSFLSVMGSKVKYRDSTLY
                     GGLIGGLIITFLLMMINLGLISQFDKIKHVDLPTLKLATQMSPSIGIIMSVIMILVIYN
                     TVVGLMYAFASRFSVPFSRRYFIIIITMAVITYISTFIGFISLIGKVFPIMGLFGFILL
                     IPVLYKGLIKRITGKSHID"
     gene            complement(18554..19039)
                     /gene="tnpA"
                     /locus_tag="NW979_RS12300"
                     /old_locus_tag="NW979_12300"
     CDS             complement(18554..19039)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tnpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500412.1"
                     /locus_tag="NW979_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12300"
                     /product="IS200/IS605 family transposase"
                     /protein_id="WP_000093392.1"
                     /transl_table=11
                     /translation="MSSDTNSLAHTKWNCKYHIVFAPKYRRQVIYGKIKKDIGIILRQL
                     CERKGVEIIEAEACKDHIHMLVSIPPKLGVSSFVGYLKGKSSLMIFDRHANLKYRYGNR
                     KFWCKGFYVDTVGRNKKVIENYIRNQLQEDIVADQISMEEYLDPFTGEKNKKRKKKE"
     gene            complement(19235..19828)
                     /locus_tag="NW979_RS12305"
                     /old_locus_tag="NW979_12305"
     CDS             complement(19235..19828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501283.1"
                     /locus_tag="NW979_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_12305"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_258413545.1"
                     /transl_table=11
                     /translation="MEHIFREGQNGAPTLILLHGTGGDEFDLLPLGEALNENYHLLSIR
                     GQVSENGMNRYFKRLGEGVYDEEDLEFRGQELLAFIKEAAERYEFDIEKAVLVGFSNGS
                     NIAINLMLRSEAPFKKALLYAPLYPVEVTSTKNLSDVSVLLSMGKHDPIVPLAASEQVI
                     NLFKTRGAQVEEVWVNGHEITETGLTAGQQILGK"
     misc_feature    20427..20441
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.93"
                     /tool="antismash"
ORIGIN
        1 atgattctgc atcttcaaat tttactgcca ctttcatcat ttcaagttgt ttcttcattt
       61 cttttacgat aggtagtctc tctttatttt taactcttga aaatgcaaat gactctagca
      121 tcagtcgcaa atcgtacatt tctttctttt cttgttcccc aaacggcaac acatgtgcac
      181 ccattctttc taattggatg agttgatttt gttgcaataa tttaaatgca tctcgaattg
      241 gtgaacgact cacattaaat tgctttgcca tttgattttc agtgagtaac gtaccttcag
      301 ctatgtgacc attcacaatg cctaagcgta attctgctgc gatactttct ccagttgtca
      361 taccttccaa ccatttctct ggatatccat acatcatcaa agcactcctt cattacacga
      421 catacttgta tacaagtatg ttaatatagt tctcaagcgt ttgcaagcgc tttctttacg
      481 tgtactaaaa tagtgaccac cccttttcga tgtaagttta aagggaatgg tcactatcac
      541 acgaatgatt taattgttat gttgtatgtg ggatatttct aattgttctg tactcttatg
      601 cgctttaggt acttcaatgc aatagtgcgt ttcatgacag ttcggacatt cgaatcgacg
      661 tgttgtcgct gtatgtttcg ctttgataac ttgccataaa gatggtgaga atatatgctg
      721 gcagttagga cataaatagg caaccttttg ttggtaataa aaagtaacac caatgccgta
      781 tccaatcata aacggcaacg caattaaaaa cggccattta tttttcatca aaattgcact
      841 cataatgcta gaatattgaa ttattcctat aatacccgca ctaatccaaa tgttacgacg
      901 aatacttttc atttcagctg atttactcat gacatgctct atgtctttta agtgtgtgat
      961 tggagacgtc gacgcttcat ttacgtaata ttgaacattt ttaattttgt ttaataccgc
     1021 ttgttgctgt ttgacttgtt ggttaatttc ttgttgtttc atagttagca aagtattgag
     1081 cgtcttcaaa gtaccttcac cttttagcaa catatctata tcgcttaacg cacaacctaa
     1141 atctttaagc aataagatca actctaatgt ttgtcgctgt tgttctgtat acacacgacg
     1201 ctttccttct gtaaatcctt gtggcttcaa aatacctttg cgatcataat attgaatcgt
     1261 tcgtgttgtc acattgcata attttgcgag ttctccagtc gaatagttag acatagattc
     1321 cacctcctac aattaccata gttgatgacc cgacgtcacg agcaagtaca atttccatat
     1381 ttttaagaaa tttattatac taggcgtctt attgttgtga tttcgcacca tgttgattta
     1441 caaaatcact caaattaagc aacacaccta ctatacgtct actctgttat ttcagaatga
     1501 atttgttgta atttattttc aacttcagta atctctgtcg cacattcttt caataaatct
     1561 cgatactttt ccgtctctgc cttattttta taacgtattt tatgttctaa acttgcccac
     1621 atatccatac ctattgttct aatttgaatt tcaacaggca atacctcaac gcgttctgct
     1681 aaaaagactg gaatggatac aacgatatgt aaactgcggt aaccattttc tttagggtgc
     1741 tgaatataat ctttacgttt tatcaattgt acgtcttctt gtttaagcaa catctcttca
     1801 atcaaataaa tatcatctaa gtaattacat actacgcgaa ttccggcaat atccagtatg
     1861 tgttctttgg cagtttctgc gctaatctgt aatcctttac gattaagctt ttctattaaa
     1921 ctacgcattt ctttcacacg tcgctccata tgatgtatag gattgtgttt ataaatgtga
     1981 ttgaaattgt catctaaaat actcagttta gtgcttattt cctttagtgc tgacgaataa
     2041 atatgatcta actctacgaa acctaataac gtatcaaatg cttcatcacc attttcaaat
     2101 ttacttaaac tatttttaaa atcatgtcgc aaatcctcta aatatagtga tggttttcga
     2161 tctacataca tttttatact aacctccgat atataatcat ctttattgta cctaacattt
     2221 tattaagata atactaatac actatcgaac tttgggctga tactgaaaca gcacaaagaa
     2281 actcaaacaa ttcgaattat gtatcaaaac cttcaattat aggaagtgat tttaaaatga
     2341 tttaacgcaa aaaaacacct gttaccgtta tataggtaca agtgcttaat tgatagagat
     2401 gttatacgtc tttaaatgat tccacaactt ttggatgtgg accatccata agcggttctc
     2461 tttgtcgaac gccaccactt tggttgccaa ttgattcgct atcaaagtac gatttatctt
     2521 gatttgattg ttcttgaata tgttcttcat tatcagttgt tgcatattca ctatccacct
     2581 ctgttttttc cattgttgct gtatggaatt gtacgaagtt ctcttcttct aatgctttga
     2641 tttcttcttt cgataacgct cgataccaat ctttcgcttt tttcgccgca ataggaacaa
     2701 catctttttc aagatatcct tcttttaaca ttgcattcgc aatttctatc gctttttgcc
     2761 gtttaattac ttcaaaatct ttccattttt cggggtaacc tttcattgta aagggcattt
     2821 ccttaacctc caatatgtta taattcatgt tatataccac cataattata aaatgaaaca
     2881 tattaaacac aattttttag actcccgtca taataacttc agacaaacgt tagtctgacc
     2941 tgataaatat tttattttaa acgttcttgt ctctctcacg aaaaccattg tgctgaatat
     3001 tcatcattgc tgattgaata taattatact gtggtaaatc tggtaatatc tttatttcta
     3061 attctgtatt taattctaaa tgcttagcga tgttttcaaa tgttgctaaa tactcgccca
     3121 ttaattgttc atttattgta agtctatctt cattagccat ggctctattt aacataaagc
     3181 taatttcttc taatgcgaat aagctaggat aataattttg aatcaatgtc ttatcactaa
     3241 ataattcacc attagctgca ttataaactt gcgtcatgtt atttaatttc acagataggt
     3301 tcatagccgt gtttttctga tacacatcat ctttatattg gttttcagaa aataaataat
     3361 ggaagagcgt tgcttcttta cgaacaactt cagccattac attaggaagc aatgcggatg
     3421 cggtacgttg tccaaggaca aataaaccta tgattgcaat cacaataccc attgcaacgt
     3481 caataactct tggaaacgca atgttaattg ttaaattctg tgatgctaat ccattcatta
     3541 aaataacttg tattgtaata aagactactg caatcgcata atttgctccc accaatgctt
     3601 cagtaaacaa tgctgcaatg cccattaaaa ttactgcaac aggtgttggt attgaaaaca
     3661 acaatataac tgaaagtact aacacaccta aaatagtacc taaacctcgt gccatacctc
     3721 tctcgattgc atgtatagtt gatgttccta gtaatattgt atgtgcagat aacggtatcc
     3781 agtatgcttt ttcaaaatca aacattaacg caataaatat cgctatcatc ataatcgctg
     3841 tatatctcaa tgtatttcta aaaacaatag agtctaatgt taaattttga taaatgcgtt
     3901 tactatataa aggttttcgc atgtctgctt catacgcaat acgcgcttca tttgcatgca
     3961 ccatttcatc aattttcaat atatggttga ataaattttg aaattcctct gttactgtca
     4021 cttcttttcg ccaatatctt acattttcct cactattatc tagttgtgca atgatatgat
     4081 ccatcatttc aattaactca tctggcaatg gtcgaatttg tttagcgttc aactctaaca
     4141 gttcagaata aatcccttgg gcagatgtgt gtaataataa taatttttga aaacgtctac
     4201 ttaatttatc gttacttgaa gtagaagtga ttaataattt atcagatgct ttaaaactat
     4261 ccaccgctgt ttttgctact tgtaaaaatg cagatttatc attataagtg tgtaacaact
     4321 tagatatgag tttaaaatca ttttgaattg cttgttcttc agctttgttt ttagaaaata
     4381 cgatcgtgat taacaccatc atagtggcaa gtataccgcc tactaaaatc gcaaagcctc
     4441 tatataatgc ttcttcggga gctataggta agttaatggg tagactgaat gtcacaatga
     4501 agaatgtcga tgacggtcca gctattttta aggcagtaaa tatataaaat ggtataaccg
     4561 taacaattaa taatgtcatt ccaaaaacga gtggcgtttt tgctgttagc gtaccaagca
     4621 tcatacatat tgcaaacgct aaattacaaa ttattacagt tcgcagctta gatcgcgacg
     4681 gacctttaaa aacataaata tgggctagtg ttccggttgc aactaataat ccaaattgga
     4741 aattaccaca taagtaaccg attattgcgg gaataatcat taacagtccc tgtcttacac
     4801 ctttataaaa gtctaagtta agtcgattga tttttatgag tgatgtcaaa aagatgtcat
     4861 ttcgacttct cctttccttg tcaaaatatt tccataatct ttttattagc atagttaaaa
     4921 tgaatttgtt gctataaatt ttaattacgc aacatatgtc attataacac cttatgctca
     4981 attatctaaa tttaaaaact tttaaagtcc aattaaaatt attttctaat gttatttaac
     5041 atcgttgaac ctttggtcgc ccacctttgc gctagttaaa atttatttgt gacatgttga
     5101 aattatttta gtgaattata catttagggt tagaaaaaca ttcacataga cttagtgtct
     5161 atttacttca tattattcct agggttcaag atccaaacta tagtaaattt aagaaagttt
     5221 ataaaacata tttgcttcat aagcttgaat agttcctata ttcgttattt aaaatgacat
     5281 tcgatgtcag ttcatttttt aaaatatcga aagatgctta cgtataatat atatagtgac
     5341 gtatttacaa ataatggcag taagcagtac aaaatgatta cacaaaaatt tccttctact
     5401 cgataaatta agaagaataa actaattaaa aaaatactta taattagacc tataagaggc
     5461 aaacttctaa tatatttctc taagttttcc ttcatattta taacctccta aaatttatat
     5521 gtacttttac aagcgttacc tgactattgt tttaaaacct tatttcttta catatatcat
     5581 tttaataact tcccgttcat cttaaaccgt atctgtttta aaaagtttca atttcaacgt
     5641 aaaaaaagca ataagcccca acaatgtgaa agcttactgc ttgtttaaat tatttttcta
     5701 ttgctttatc atcactaaca attaaaggtt gatctggttt cacatagaac cacataatca
     5761 cagcgattac tgctggaacg attaacaatt ggaatgtcat tgtccaacct aaatgttcta
     5821 cgaatagacc tgctaatagc ggactgatta atgcacctat attaccccat aagttcatcc
     5881 atcctgatac tgtaccagag aagttacgtc ctaagtcagt tgctgcagcc caactcatac
     5941 ccattgaaat accgatacca ccaagaccta gtgataacca gaaaatactt acatataaat
     6001 ttcctgtacg tacagcaaag ataattgaaa ctgcaaatac aataaatcct gcgattgcaa
     6061 tgacacctct agctacgaat tttgaacgac ctaatcctaa tacacggtca gaaattgcac
     6121 ctgctgataa gattaagaag aacattaata accaaggcaa tgaactaatg ctcatttctt
     6181 taaagttaac gtggaatact tctgttaaat acgtcggtaa ccaaattaag aataatgtaa
     6241 tgataaattg tacaacaaag tattgaattg caattgcata gaagctaaaa cgtttaaaga
     6301 aatcattcca tggtggtgat gacttttcag tagctacgat atcacgattt tccataatga
     6361 aacgtttctc cgcttcatta accattctat gttgctcagg taagtctttg gcaataatcg
     6421 cccataatac agccattaaa atacctactg caccaaaaat gtaaaatact gcttgccagt
     6481 taaatgcgtt aacaatagca attgtaacta ttggtgctaa tacaggtccg aaatatgatc
     6541 ctgctaataa tgcacttgat gctctacctt tttcattttt agagaaccaa aatgagttaa
     6601 acacagcatt agaagggtac attggcgcct cacccacacc aaataagaat ctcactaaat
     6661 aaattaaacc gtggttctta atcatacccg ttaagattgt aaatgcactc caccaaacta
     6721 atgcaattgt aatcatctta cgtggaccga atttttcagc caacatcccc gatggtactt
     6781 gcattaatgc ataacctaga gagaagaatg atgccaataa accaaattgt ggtttggtca
     6841 tccctaaatc atccatcatt tgcttagcga tatatgaaat gtttgctcta tccatatacg
     6901 caataacccc aataaagaag aacgcaagcg cgaacatcca ccttacgtta gttcgttttt
     6961 ccttcataac tattcctact tccctaatta aatttttaaa acttaccctg aaacgttaaa
     7021 attttcggac atctggcatg tccaccccta ctttgtcaca aaattgtacc aaagttattt
     7081 tttataatat tatcagacat ggaaagcgtt tacaatagaa tctataaaaa ttttattaaa
     7141 ttccgcttaa cttttgctat taaaacgata taaaggaact tttagttaca tagtagccta
     7201 tcgtttgtta attaaaaata ctgcaatcct agtgttttaa aacgtatatt gcaggctttc
     7261 ttacatattc gacattcatt ttaaattgca taaaactaca ttgctcattc attgtgcagc
     7321 gcctgttatt tagatgatca tttgttgact tttcgtactt atagcaagca attttttgat
     7381 ttattgctta taatacattt taagacaaat gcttgtttca acatcgcata cgacatcatt
     7441 cattattcat ttgaatttat ccagtttcta tttgtctgca attgctgaaa attaaaggag
     7501 cttattttta ataatggaac aaattatcac tgaatttatt agtcgttttg ggtatgcagc
     7561 catttttata ttaattttat tagaaaatgt tttacctatc gtaccatcgg aaattattct
     7621 gacatttgct ggccttatgt ctgttaaatc acatttatca attttaacct tatttattat
     7681 tgcaactatc gcatcgttta tagggctgtt aattttatat tatatctgtc gtttgatttc
     7741 agaagaacgt ctatatcgtt ttattgatcg acacggtaag tggattaaat tgaaaagtaa
     7801 ggatttaaag cgagcaaatg attggtttaa aaagtatggc gtatgggctg tatttatctg
     7861 tcgtttcata cctgtattac gtgtattgat taccattcca gccggtgtaa accgcatgaa
     7921 tgttgtgaca tttaccgtta tttcattaat aggtacaaca atttggaatt tcggtttaat
     7981 tttactagga cgcacgttga gcgatagctt tggtatgttg atgactggtc ttcatacata
     8041 ttcacgtatt atgtatgttg tcatcattat cgcagtcatt tactttgcta tacgttacat
     8101 tggcaaacgt aagagagtaa aataatattg ttgttagtat aaaggcataa attttaaatt
     8161 tctataaaca aaaagcagtg aatcattcca tctattgaaa tgattcactg cttttttaag
     8221 tttatttggc atgctttagc tgaaagtcac ctatctttat ataaagaaat attattatta
     8281 acatgctagt tatagttgtg aagtaaaatg gtaccaatga gtgagaaatg ataccaatta
     8341 ataatgcacc gacagtcatt ccaatatatc tcacaaagtt aaatacacct aacacttttc
     8401 cttttatatg ttcaaacctt ttagaaatta tagtagacag caaagctggc acaataccaa
     8461 cacaagtacc taatataaat ataattactg ataatataat tacatttgat tcgtttaacc
     8521 atccaaacaa taatgtaaat atagcaaatc cagttatagt aacacgaagt atcattattt
     8581 cattataatt ttttgacaat cgtttataaa ataaacttcc taatataaca ctaacagtaa
     8641 taggtaaaaa caaaactcct gatattccaa cgcctatatc ataggtatta tttaataatg
     8701 tcggtaaata aactaatatt gaaaagtacg taaaaaatat taaaaatccc aatgtcacta
     8761 aagtaataaa cactttatcg gtcaaatatt tttcttcaat tttttcagtt aattttacaa
     8821 tccctttttc aacatttgga atatcaataa aaaagataat cagaaataat acgatagata
     8881 taacaagcaa aaaactaaaa ataccaatat aatcccatct tgcacctaaa gtactcccta
     8941 ggattggtgc caaagctggc gcacatgata aaaatatttg atagttcgcc atagcttgag
     9001 ctctaccatt atctgtactt agtttggcta ataaagttaa agtcacgaga ggaataattc
     9061 cgcaaccaat tgcttgaaac aaccttgata tagcaaataa tataaagtta tgtgtcattg
     9121 cacaaataaa gctagatatg attactattc ccaatcccgt taaaagtact tttttcgaat
     9181 cacaagaatc tatacttcta ccaagtacaa tttgcataac tgcaacgata aatataaaac
     9241 cgccaactgt cgcatttatc caaaatagtg gtacttgaaa atcgtcatat agtctcggaa
     9301 taataggcgt gtatatgttt tgaatcaatg atgcgaaaaa tgctaaaaat cctagaatat
     9361 ataatctgat attactatta gtcatttaaa ccatcttctt tttttaattc ttctatacta
     9421 cggtttaaaa actctacaat aactgccatt tcatcattat caaagacttt aagtacttct
     9481 tcatattttt ttaccgcttt ttcatgtaat tcatcatgta tataagataa ttttttccct
     9541 ttttgtgtta atgaataatt aacttctctt ttgttaaatt cattgtgcga ttcaactact
     9601 aagtctttcg ctaaaagttt ttttatcgat ttagtaattg ctggttttga tacatttaac
     9661 atttcagaca aaaatttatt attcacttta tcattattat caatcaactc tataatatga
     9721 aattgtgtta gagataaatc caattcctca ttttcttttt tatactgtct tcttttatcg
     9781 gcattttctc tttctataat aaattgttgt aattttaaaa taacttctct cttcatatcc
     9841 actattattc ctcctcttca ttagttaacc ggttaactat attattgttt aaactctctc
     9901 ttttgtcaaa tataattgtc taaagtaaat aaatttgtta tctttatatt gttaaccggt
     9961 aaaatattaa ttggttaata attagaattg gggggataac atgaaagatt ttgaaattag
    10021 ttttttaact gagaattgca aaaaaattta tcaacgaaaa aaacatgtta ctttaggaat
    10081 tagtccattt acaagcaagt acaatgaact gtatatcaaa aaaattattc aatgggctaa
    10141 tttaaatttt gaagaatttt ctattctatt agctggaaat gaatcaaaaa atcttttgga
    10201 atgcctaggt tattcatcat caaaagcaaa tcaaaaggtc agaaaagaaa ttaagaggca
    10261 aattagattt tgtgaagatg cgatcttgaa atgtaacaaa actataacca acagaatcca
    10321 cagattttct gatttcaaac aacatatttc ttatattgaa ttatatcaac agattgtaaa
    10381 tcaattcaat acagactcta atttcagaag ttgttgttta aaaatgtcgc ttaaagcatt
    10441 acagagtaaa aaagaaaatc ttaataaacc tgtattaatt accgatgaat ctttagagta
    10501 tgcagcacag tatgtcttag ccgaattacc atttttttta aatgctaatc ctattattaa
    10561 tactcaagaa acgatactgg cttatcacgc tccttggaaa ctaggtacag atatcattaa
    10621 taataaattc aacttaaaaa tggataaaaa tcaaggttat attattttaa ctgaaaaagg
    10681 ggataattat gttaaaagtt tataatagta ttttcgacca agcctatgaa atagacccta
    10741 ttccctattt caacttttta cgaaaacacg atccagttca ttatgaagaa tctattgatg
    10801 cctattttgt aagtaaatat aaggatgtta aatatatact gaaaaataat gatatattta
    10861 acactaaaac tttagctaaa agagccgagc ctgttatgaa agatagggtt ttagctcaaa
    10921 tgtcaggcca agaacacaaa tccaagaaaa aagctatatt aaagggaatg actggtaaat
    10981 atctcgagaa tttaatgcca atattagaga aaagaaccaa tgatataatt aacaaacata
    11041 ttgaaaaaaa agaaatagat atagtaaacg actttggaaa ggtatttgct gttcaaagtt
    11101 ccatggattt attaggtatt aatttagaaa attacgaaaa aatcagggaa tggcataatg
    11161 gaatagctaa atttataaca tcattcaatt tgaatgatga agaaattaaa tattctcttg
    11221 agtgtagcga taaactagaa aattacttga tgccattaat taaggataga aaaaaatcaa
    11281 ctaaagatga tttaatttct attctacttg aatataaaaa cgatgataat agtataagtg
    11341 atacagaaat actcgcttta tctttaaatg ttctattagc tgcaacagag ccagttgata
    11401 aaacattagc ttatttattt tacaatttat taaaaaatcc tgagcaattt gaaagtgtta
    11461 aaaacaatcc taaattaata aaaaatgcca tcattgaaac tcttagatac aattcacctg
    11521 ttcaactaat accaaggcaa gtatcaaaac cattcatatt caataatact gagttgcaag
    11581 ctggagatac tgtaatatgt atgataggat cagcaaacag agatcctgaa gcatatagta
    11641 atcctgatga atttaatatt catagaagtt ctgataataa atcacctttt acctcccatt
    11701 cacaaaattt atcattcgga actggtgtgc atacatgtgt cggtgcctct ttctctttaa
    11761 tacaactaga aatggtagca atcttattac taaaacgtct aaaaaatata aaattaaaaa
    11821 caatggaaat tacagaacac ggtatatata ctaggggacc taaatcaatg gtgattagtt
    11881 tcgattgatt attaacttta tgctctttaa gtctattgat tacggaagat gtagttattg
    11941 tcatattaca atttacaata ctcaaaaaac taaattaaat acaacaatca atgtcaatat
    12001 tttgaaacag tacttaatcg agtaggcgaa taattattat ttaattgttc accctccggt
    12061 tccgtactca gcggttcaat atctagtgta agttgtctct gcgagttggg ttagtgatag
    12121 taaccctcac ttgtggaggc gttttgttgg aattgcacgt tgaacctcgt gcgtagatga
    12181 taaacgccag tatttctttc ttgagctcgc aattctcatt gcgctatcat ggttaagacc
    12241 atacttgcgc aacatcttat aatttgtttt aaccttcttc catcttttga gtataagttg
    12301 tctaatgcga tgatgtagcc tcgattctac ttctttcaga aattcttttc caaaatagtt
    12361 tatccatatt catgttgcaa aattaatttc tgttataata tggtggaatg tacacctagt
    12421 ctacttcgtt tggttaacca ctttaagttg cgttttaaat ttcttgtcca tatattaagt
    12481 gccattaata caaaacctat ctctcatttt acttatttat acctcgaact gacattctaa
    12541 tgaagcccaa actaaccttc ataaatccaa acaggttcta catcattttt tctttgacta
    12601 tagatttttt cgtttctggt tcagaaatct tttgatgaat ttggactata actttttccc
    12661 aattataatt tctcatgatt ttcttattgg atttcgaatt tggtttcaag cattgatgct
    12721 tcaaagaaca tgctgaacag tcatagcatt catacagctg aaagtcacct aaaacccttt
    12781 acgttaagag atataatgaa gtttcccatc aaagttcagt tccctcagta tgtatacatt
    12841 ccgtataccc atctcacaaa tccatctata atacaaacta tcattttaaa taagcagaat
    12901 ttaccctgtc ttccacacaa actgttttcg tcactttaat atgccttcta ttcaaaaaag
    12961 tcactcataa ctaattgcgt attttaataa atttagcaat gccatttgca tgctgcaaaa
    13021 atacttatat taatatttat attttatatt atttaagttt tttaaatcca tatttttata
    13081 acacttgata tgtgataaaa ttaattttat atataatctt aagattcaga ttatttaata
    13141 gcaaaggaga tagtgatatg gatgttttaa caatagaaca tttaacaaag aagataggca
    13201 acaaaacgat tctcgaagat gtatcattta agctgaaacg cggacaaata gttggtcttg
    13261 ttggagcgaa tggtgcaggt aaaacaactt taatgaaagt tatattaggt tactctagtt
    13321 tccaaagtgg aaattttaat gttattaaca gcaaggacag caaaaacaat atcggtgcat
    13381 tgattgaaaa tccaggaata tatcctttta tgtctggata tgaaaacttg aggttattga
    13441 atgaatcaaa aaacactcaa gatatcgata aaattgtctc acaacttcat atggatgaat
    13501 acattcataa aaaagctaaa acgtattctc ttggtatgaa acaaaaatta ggaattgcta
    13561 tagcattttt aaatgaacct caatttatta tcttagatga accaatgaat ggcttagatc
    13621 caaaagctgt gcgagatgta cgtgaattga ttgtccataa agcgcaagaa ggtgttactt
    13681 tcttaatttc gagtcatatt ttaagtgaat tagttaaaat cacaaactct atccttatta
    13741 ttaacaaagg taaaattgtt acagaaacat cggaagaaga acttaaacaa tttaaagata
    13801 atgatttaga aaatgtatta ctagaaatca tagaaaggga ggaccaagca taaaatggga
    13861 actttaatta aacaagaatg tttcaaatta tttaaaaaga aatcaacttt tatcgcacct
    13921 attgtcttta ttctactaat ggttgctcaa ggttatattg ctacaaaata caatgaaatt
    13981 tttacgccac aggaatcttt cacatctgct tataatggtt tttcatggtt tgcattttta
    14041 ttaattattc aagcaagtac aatcatttca atggaatttc attacggtac gattaaaaat
    14101 ttactctatc gtgaatattc aagaacaact atgattgtta gcaaaatcat cacattattt
    14161 attatttctt taatttattt tgttattaca attattgctt caattgttat tgggtcttta
    14221 ttctttaatg atttaaatat atttgaaagt agcggtaatc aattatcttt attgaatcaa
    14281 ttattattag ttagtttagg tacatttgtt ggcgtttggt tagttttaag cttaacgttg
    14341 ttattatcat ctgcaactaa ttcaacgggt gtagccattg ctgtaggtat tgttttttat
    14401 tttgcaagtt ctattttagc agttattcaa acggcacttt tagaaaaaat agactggcta
    14461 aagtggaatc ctattaatat gatgaatatt atgcttcaaa cagttgaaaa aggctttagt
    14521 aagtcgacga aattagaact tcatgaattg tttattggta atattgctta tatttctatt
    14581 ttcttaatac ttgtagtatt tattttcaag aagaaaaata tttagtaact taaagtatta
    14641 gatgaataaa tacacacata ttccatcgta actcaaaatc attttcaaat cccttcacca
    14701 aaataatggt gcggggattt ttttcatcca aattttggca attacacatt ttacatatcg
    14761 taatttttta ggaaacttgt gaatataaca aattcctcct ctcattttta aaatagatat
    14821 atcacttctc cacttttact taactaaact gcaacggctc ctaataccaa aatcctgccc
    14881 tctattttta tcaattcaag catacttatt gaaaaatgtt aacgttttct tgataatcat
    14941 tgtaagcgca tttattttat aaactaacgt ttgaaatata ctacaggagt gacacgtaat
    15001 gactcaaatt actgaaaaag aattaaaaaa gaagtattta gatttactat cccaaaattt
    15061 tgatactcca gaaaaacttg caactgaaat tatcaattta gaatcaattt tagaattacc
    15121 taaaggtacg gagcatttcg tcagcgattt acatggtgaa tatgaagctt tccaacacgt
    15181 attacgcaac ggttctggga acgtgcgagc gaaaatcaat gatattttca aagacaagtt
    15241 atcaacgaaa gaacttaatg atttgactgc ccttgtttac tatccagaag acaaattgca
    15301 acttattaaa tgcgattttc aaaattatgg acaattaaat gtttggtata ttacgacgat
    15361 tgaacatctc attcagctaa ttaaatattg ttcttcaaaa tatacgcgtt caaaacttcg
    15421 acgtgctttg ccggagcaat acgttttcat cgtagaagag ttattatata agaacaacga
    15481 atttaaaaat aaaaaatctt actacgaaac acttgtaaat caagtgattg agcttaagca
    15541 agcggatgat ttaattatag ggcttgcgta ttctgtacaa cgcttagtcg tcgatcattt
    15601 acacgttgtc ggtgatattt atgatcgtgg cccgcaacca gataaaatca tggacacgct
    15661 aattaattat cattctctgg atattcaatg gggtaatcat gatgtgctgt gggttggtgc
    15721 ttatgcaggg tctaaagtat gtttagctaa tttactacgt atttgtgcac gttatgacaa
    15781 tctagatatc gtcgaagatg cttacggtat taatttaaga cctttgctaa cattagccga
    15841 aaaatactat gatgcagata accctgcttt taaacctaaa aaaagacctg acaaacatga
    15901 acgtttaaca caacgcgaag aaagtcagat tactaaaatt catcaagcta ttgcgatgat
    15961 tcaattcaaa ctggaaatac cggttattaa gcgccgtcca aactttgaaa tggacgaacg
    16021 acttgtactt gaaaaagtta attatgatac taatgaaata acagtatacg gaaaaacata
    16081 tccattaaaa gatacatgtt tccaaactat caatcgtgat aatccagcag aattactacc
    16141 tgaagaagaa gaagtcatga ataaactatt attgtcattc caacaatctg aaaaattacg
    16201 tcgtcatatg tctttcttga tgcgtaaagg ctcactttac ttgccttgta atggcaattt
    16261 actcattcat ggttgtattc cagttgatga aaatggtgag atggaatcat tcgaaattga
    16321 tggtcagaca tacagtggcc aagagttatt agatgtgttt gaatatcatg tccgtaaatc
    16381 atttgatgaa aaagaaaata ctgatgactt atccactgat ttagtttggt atttatggac
    16441 tgggaaatat tcttcactat ttggtaaacg tgcgatgact acgtttgagc gatattttat
    16501 tgcagataaa gcttctcata aagaagaaaa aaatccatac tatcatctac gtgaagatgt
    16561 gaatatggtt cgtaaaatgc tcagtgattt cggattaaat ccagatgaag gacgcattat
    16621 taatggtcac acaccagtga aagaaatcaa tggcgaagat cctatcaagg ctgatggaaa
    16681 gatgcttgtc attgatggtg gcttttcaaa agcttatcag tcaacaactg gcattgcagg
    16741 ttatacattg ttgtataatt cattcggaat gcaactcgtt gcacatcaac aatttaacgc
    16801 aaaagaaaaa attctttccg aaggtatcga cgaactgtca attaaacgga ttgttgataa
    16861 agaattgcaa cgtaaaaaaa tccgtaatac aaataaaggt aaagagcttc aagctcaaat
    16921 agatattttg aaaatgttaa tgcatgatcg ttacttagac taaagacgac atttgatgca
    16981 tgtatcgcgc acttatttag tggtgctgtg tttacgcatt ggctacgcaa acgcgatgat
    17041 aaataggcga cctagctaca cctaaaaaaa tcccctcact attgcgagta gtgaggggat
    17101 tggtgtgtct atgctagttc ctgttaactg tattataaca actttacagc aaaaaaatgc
    17161 aaaatcaact aataaattaa tgaaatgacc gacgccctcg cttctactcc aatttaacaa
    17221 aatactatat tagtactata tttttcatta acatgtatgt tacattttct atattactta
    17281 aaattacgaa gggacatttt taaatcatgc gcatcttaaa agagtccatt attgtggcat
    17341 ttgcctttgt tggtgttgtc gttggtgccg gctttgctac tggtcaagaa attttccagt
    17401 ttttcacaag tcatggcgcg tatagcattt caggcattat tgtgacagga ctattgatta
    17461 ctttaggtgg aatgattgtc atgcatacag gtcatcatct aaagtctaga aatcattctg
    17521 attcaattaa ctatttctta tacccctcta ttgcaagagg ttttgatatt attttgacaa
    17581 tgtttatgtt gtctctagct attattatga ctgcaggtgg cgcgtcaacc attcatcaaa
    17641 gtttcaactt accgtattgg ctgagcgcac tcatattagt cgcctttatt ttagcaacac
    17701 tgtttctaaa attcgatcgt ttaattgctg tgcttggtgg agttacccca tttttaattg
    17761 caattgtcat tatgattgcg gtctactatt tcacaacgag tcatcttgat tttactgccg
    17821 ctaataatga tgctcagatt cataagcaga aatcattatc acctggatgg tggtttgatg
    17881 cgattaacta tgcaagtttg caaattgctg ctgccttcag cttcttatca gtgatgggta
    17941 gcaaagttaa atatcgtgac tcaacgttat acgggggctt aattggcggt ttaatcatta
    18001 catttttact catgatgatt aatctaggtt taatttctca attcgataaa attaaacacg
    18061 tcgatttacc tacattaaaa ttagcgacac aaatgtctcc gtcaattggt attattatgt
    18121 ctgtcattat gatacttgtc atctacaata ctgttgttgg attaatgtat gcatttgcgt
    18181 cacgtttcag cgttccattt agcagacgtt acttcatcat tattattaca atggctgtca
    18241 tcacttatat tagtacattt atcggtttca tttcattaat tggaaaagta ttccctatta
    18301 tgggattgtt cggtttcatc ttactcatac ctgtactcta taaaggttta attaagcgta
    18361 ttaccggcaa atctcatatt gattaaaata tctatactat tgtaaaattt agtacaacac
    18421 ttcaaaatca aatcaaaacc acccgtgtga acgggtggtt tgttctgcgg ctataagcct
    18481 tccttactgg ccagccctaa aagggcactg acaagtcagc caactgcact actattccag
    18541 caaccctaaa gggttactct tttttctttc tttttttatt tttctctcca gtgaaaggat
    18601 ctaaatattc ttccattgag atttggtctg caacgatatc ctcttgtaat tgattacgaa
    18661 tataattttc aatcactttt ttatttctac ctactgtatc cacataaaat cctttacacc
    18721 aaaactttct atttccatat ctatacttta agttagcatg tctatcaaat atcattaaac
    18781 tactttttcc ttttaaatag ccaacaaatg atgatacccc aagtttgggt ggtatactaa
    18841 ctaacatatg gatatgatct ttacatgcct ctgcttcaat tatctctaca ccttttcttt
    18901 cacataattg acgcaatata atccctatat ctttttttat ttttccatat atcacttgtc
    18961 ttctgtattt aggtgcaaag acaatatgat acttacaatt ccattttgta tgtgctaaac
    19021 tgtttgtgtc agatgacatt aaatagcatc tcctcgtgtt gattattttg gttggctgac
    19081 caatatttat tctagcacgt agagatgcat tttttgtgac aatggtagaa ccttttctga
    19141 accatacgca tagcgtatgg ttttcttttt acaaaaaaag cggacagatg aaaagtaaaa
    19201 atcttttcca tctgtccgct tcttaataga actgttattt cccaagtatt tgttgaccag
    19261 ccgttaatcc agtttctgta atttcatgac cattcaccca aacttcttcg acttgtgccc
    19321 cacgtgtctt aaacaagtta atgacttgtt cacttgcagc taatggcaca attggatcat
    19381 gtttccccat agaaagcaac acactgacat ctgataaatt ctttgttgac gttacttcaa
    19441 ctgggtataa cggggcatat aacaatgctt ttttaaatgg tgcttctgaa cgcaacatta
    19501 agttaatcgc tatatttgat ccatttgaaa atccaacaag cacagccttt tcaatatcaa
    19561 attcataacg ttcagcagct tctttaatga acgctaacaa ttcttgtcca cgaaattcca
    19621 aatcttcttc atcataaaca ccttcaccaa gacgtttgaa ataccggttc atcccatttt
    19681 ctgaaacttg tcctctaata cttaacaagt gataattttc attcaatgct tcgcctaatg
    19741 gtaataaatc gaactcatca ccacctgtac catgcaataa tattagcgtt ggcgcaccat
    19801 tttgtccttc tctaaaaata tgttccatca caaatcctcc tcattccaat taatcatgtt
    19861 gacatttcgt attaaaaggt ctaacttccg attcaatata ttctctttta ttttctaaaa
    19921 atggtggtaa ggataaccct tcgcctaatg tttcataagg ttcatcttcc ataaatcctg
    19981 gtccatctgt tgaaatttct attaaaatat gccccacacg tgcatataat gcttcaaaat
    20041 agaaacgatt aacgatgcct gagttgttaa tacctacctc tttatatttc gttgcccacg
    20101 cttctattgc atcatgatct ttcacacgaa atgacacatg atgtacctca ccataacctt
    20161 gacgtgctgc tggcccttta tcatccttga ttaagattac ttggccacca ttgcctcctt
    20221 cgccaacttc aagtaatgcg acattatctt catgcgcaat agttgtcata ccgtaaacag
    20281 tctctaaaat atttttaaag tcgtcaaaat aacttacttt aatttcaatg gggcctaatc
    20341 cataaatcgc tttatctact ggaaccggtc cattcttcca aggtacacca ggtgctaccc
    20401 cttcatttaa ctcatctgaa attaattgat acacttggcc atcgacttct tcaaatggca
    20461 acactttttt accaaataat tcttgaatac cttcgtgttt aacaccaaat tcatcaaagc
    20521 gctgttcata atacattaat gcgtcatcgt taggcactct aaaagacggt cttgtaatgg
    20581 aatttgttcc tgcctgccct tttgtaatat ttggaaaatc aaagaacgtc atgtctgtac
    20641 ctgccgaacc tacatcatct gcaaaaaatg tatgatacgt ataaatatca tcttgattga
    20701 ctgtc
//
