LOCUS       NZ_CP102959            24231 bp    DNA     circular CON 09-JUL-2024
DEFINITION  Staphylococcus aureus strain 12-G-51 chromosome, complete genome.
ACCESSION   NZ_CP102959
VERSION     NZ_CP102959.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 2744047)
  AUTHORS   Monecke,S., Roberts,M.C., Braun,S.D., Diezel,C., Muller,E.,
            Reinicke,M., Linde,J., Joshi,P.R., Paudel,S., Acharya,M.,
            Chalise,M.K., Fessler,A.T., Hotzel,H., Khanal,L., Koju,N.P.,
            Schwarz,S., Kyes,R.C. and Ehricht,R.
  TITLE     Sequence Analysis of Novel Staphylococcus aureus Lineages from Wild
            and Captive Macaques
  JOURNAL   Int J Mol Sci 23 (19), 11225 (2022)
   PUBMED   36232529
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2744047)
  AUTHORS   Braun,S.D., Diezel,C., Reinicke,M., Linde,J. and Monecke,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2022) Optisch-Molekulare Diagnostik und
            Systemtechnologien, Leibniz Institute of Photonic Technology (IPHT),
            Philosophenweg 7, Jena 07743, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. v2.8.3-b1695
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 197x
            Sequencing Technology             :: Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024741495.1-RS_2024_07_09
            Annotation Date                   :: 07/09/2024 05:50:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,670
            CDSs (total)                      :: 2,588
            Genes (coding)                    :: 2,516
            CDSs (with protein)               :: 2,516
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 33 of 72
            Pseudo Genes (incomplete)         :: 43 of 72
            Pseudo Genes (internal stop)      :: 20 of 72
            Pseudo Genes (multiple problems)  :: 21 of 72
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:54:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1849039
            Orig. end                         :: 1873270
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102959.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24231
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24231
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24231
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14231](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14231)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(138..149)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     gene            complement(742..1461)
                     /gene="splD"
                     /locus_tag="NW979_RS08720"
                     /old_locus_tag="NW979_08720"
     CDS             complement(742..1461)
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /gene="splD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500439.1"
                     /locus_tag="NW979_RS08720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08720"
                     /product="serine protease SplD"
                     /protein_id="WP_001038692.1"
                     /transl_table=11
                     /translation="MNKNIIIKSIAALTILTSITGVGTTMVEGIQQTAKAENTVKQITN
                     TNVAPYSGVTWMGAGTGFVVGNHTIITNKHVTYHMKVGDEIKAHPNGFYNNGGGLYKVT
                     KIVDYPGKEDIAVVQVEEKSTQPKGRKFKDFTSKFNIASEAKENEPISVIGYPNPNGNK
                     LQMYESTGKVLSVNGNIVTSDAVVQPGSSGSPILNSKREAIGVMYASDKPTGESTRSFA
                     VYFSPEIKKFIADNLDK"
     gene            complement(1582..2301)
                     /gene="splC"
                     /locus_tag="NW979_RS08725"
                     /old_locus_tag="NW979_08725"
     CDS             complement(1582..2301)
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /gene="splC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500440.1"
                     /locus_tag="NW979_RS08725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08725"
                     /product="serine protease SplC"
                     /protein_id="WP_006190577.1"
                     /transl_table=11
                     /translation="MNKNIVIKSMAALAILTSVTGINAAVVEETQQIANAEKNVTQVKD
                     TNIFPYNGVVSFKDATGFVIGKNTIITNKHVSKDYKVGDRITAHPNGDKGNGGIYKIKS
                     ISDYPGDEDISVMNIEEQAVERGPKGFNFNENVQAFNFAKDAKVDDKIKVIGYPLPAQN
                     SFKQFESTGTIKRIKDNILNFDAYIEPGNSGSPVLNSNNEVIGVVYGGIGKIGSEYNGA
                     VYFTPQIKDFIHKHIEQ"
     gene            complement(2359..3081)
                     /gene="splB"
                     /locus_tag="NW979_RS08730"
                     /old_locus_tag="NW979_08730"
     CDS             complement(2359..3081)
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /gene="splB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500441.1"
                     /locus_tag="NW979_RS08730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08730"
                     /product="serine protease SplB"
                     /protein_id="WP_001039447.1"
                     /transl_table=11
                     /translation="MNKNVVIKSLAALTILTSVTGIGTTLVEEVQQTAKAENNVTKVKD
                     TNIFPYTGVVAFKSATGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKK
                     IINYPGKEDVSVIQVEERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKN
                     KYVLYESTGPVMSVEGSSIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAY
                     GVYFTPEIKKFIAENIDK"
     misc_feature    complement(3148..3159)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            complement(3206..3912)
                     /gene="splA"
                     /locus_tag="NW979_RS08735"
                     /old_locus_tag="NW979_08735"
                     /pseudo=""
     CDS             complement(3206..3912)
                     /codon_start=1
                     /gene="splA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500442.1"
                     /locus_tag="NW979_RS08735"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08735"
                     /product="serine protease SplA"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNKNVMVKSLTALTILTSLGFAENISDQPHSIAKAEKNVKEITDA
                     TKAPYNSVVAFAGGTGVVVGKNTIVTNKHIAKSNDIFKNRVSAHHLSKGKGGGNYDVKD
                     IVEYLGKEDLAIVHVHETSTEGLNFNKNVSYTKFADGAKMKDRNSVIGYPKGAQTKYKM
                     FESTGTINRINGTFMEFDAFAQPGNSESPVLNSKHELIGILYAGSGKDESEKNFGVYFT
                     HN"
     misc_feature    complement(4840..4851)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.09"
                     /tool="antismash"
     gene            4876..5442
                     /locus_tag="NW979_RS08740"
                     /old_locus_tag="NW979_08740"
     CDS             4876..5442
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500444.1"
                     /locus_tag="NW979_RS08740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08740"
                     /product="DUF4888 domain-containing protein"
                     /protein_id="WP_258413439.1"
                     /transl_table=11
                     /translation="MNTKFLGKTLVASALVLTTLGTGLHSSYLGLDTNKIVKTAKAEEK
                     MTDGQLWKKVKDSLHDSDIILSNEYETINVTYLLSNGYSSSVSAPGNDDGGHLTQSIDF
                     KGLKQIDLTKENVYDDFNKKLDAKNTWNSLTEKLKGLGLLQNGQKVSIYSSDSSSPVSG
                     KVGEGVTSGGENTLTKRFINKITID"
     gene            complement(5916..6614)
                     /locus_tag="NW979_RS08745"
                     /old_locus_tag="NW979_08745"
     CDS             complement(5916..6614)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500445.1"
                     /locus_tag="NW979_RS08745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08745"
                     /product="hypothetical protein"
                     /protein_id="WP_000586140.1"
                     /transl_table=11
                     /translation="MIINELKSCKLKFSKQALTFVPIIVTILFILFINWYLNVNLWNGR
                     QISLFTASFNAITSLLISINVYQVINFEENIGHFNHILGKANRLNWLNASMIFTYTITA
                     ICILLASINLLWHSHDMKITLMFIGVSLFFNVIILLLLFIFSIFIKDVMAIVVGVLMFI
                     FNVYFGLEVLGDHSWFYLPITYATRYVYMFIEGSIPVTLTLAIYIIITLLLAVLLFKGF
                     NKWSGRTIKD"
     gene            complement(6611..7372)
                     /locus_tag="NW979_RS08750"
                     /old_locus_tag="NW979_08750"
     CDS             complement(6611..7372)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500446.1"
                     /locus_tag="NW979_RS08750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08750"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_000581552.1"
                     /transl_table=11
                     /translation="MIHLKIEGIKFKNSFSMYVLLISPLVFLCFAIFTVLFAKSNTGTA
                     NSVSPYITLLFNIWPIAFIPIVLCMACNSLFKIEMRNKSFNYYLSNNWSITKEIRAKIF
                     ILSIAFLVHCFLVFIIAYIGDLIINPHPVNAMLLLVTILLMYVVSLPLIPLNFLLTRYF
                     GVFVSILINLVLSVICVLFLTLKSLFWVLPWGIMQRIPLITLGILPNGLVVNHNSKYFN
                     DLNALYISIIVSIIIFAIVTFLNNKKSWRLK"
     gene            complement(7369..8061)
                     /locus_tag="NW979_RS08755"
                     /old_locus_tag="NW979_08755"
     CDS             complement(7369..8061)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500447.1"
                     /locus_tag="NW979_RS08755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08755"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding subunit"
                     /protein_id="WP_001096791.1"
                     /transl_table=11
                     /translation="MAKLVTENISKRFKNQDVLKHINITLENNEVYGLLGINGAGKTTL
                     MKIICGILQQDSGEIKLDNRPMTRNDLHKVGSLIETPATYNHLSAQDNLKIVCLNESVD
                     FSEINSVLSLVNLNVDKKKKVKDFSLGMKQRLGIAMALIKKPEILVLDEPSNGLDPYGI
                     QELRELLKLLTEQGTSIIISSHILSEIQVLADHIGIIHEGELKYQQRNNKDENLEEIFF
                     KITKGDYK"
     gene            complement(8084..9457)
                     /locus_tag="NW979_RS08760"
                     /old_locus_tag="NW979_08760"
     CDS             complement(8084..9457)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500448.1"
                     /locus_tag="NW979_RS08760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08760"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000691541.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.9e-43, bitscore:
                     146.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNK
                     LVKKKSLNVVYNIPELHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTS
                     NESLFSRQWDMNKITNNGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVP
                     LNGFRGTEPEETGDVHDVNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTE
                     LLWVSKAIVQAANDGNQVINISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKK
                     SIVVAAAGNDGIDVNDKQKLKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSN
                     FGMNYTDIAAPGGSFAYLNQFGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKV
                     SGALALIIDKYHLEKHPDKAIELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS"
     gene            complement(9467..9985)
                     /locus_tag="NW979_RS08765"
                     /old_locus_tag="NW979_08765"
     CDS             complement(9467..9985)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500449.1"
                     /locus_tag="NW979_RS08765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08765"
                     /product="phosphopantothenate--cysteine ligase family
                     flavoprotein"
                     /protein_id="WP_000504439.1"
                     /sec_met_domain="Flavoprotein (E-value: 5.3e-29, bitscore:
                     98.0, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGENVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFIN
                     GEILKQFCDNYYDEFEDPFLNHVDIANKHDKIIILPATSNTINKIANGICDNLLLTICH
                     TAFEKLSIFPNMNLRMWENPVTQNNIRLLKDYGVSIYPANISESYELASKTFKKNVVAP
                     EPYKVLEFI"
     gene            complement(10001..11245)
                     /locus_tag="NW979_RS08770"
                     /old_locus_tag="NW979_08770"
     CDS             complement(10001..11245)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500450.1"
                     /locus_tag="NW979_RS08770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08770"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_000566596.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-85, bitscore:
                     284.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDMNLILKKKFQEISEVDDFISKASTETDYFEPSTLSHGIPGII
                     LFLDAYQKVFDINTEQIVHKYIMKLAPYLQSGQYNNSLFGGLSGIAFSMDLASQNGKNY
                     QNILNNIDGHIVNEIENKFDQILQEPLNPLNYDTVSGLAGIGRYLLNRVDENEFNVKAL
                     KSILVYFKDIQYSKNSWVVPQESQFLESDKNYFTEGNINLGLAHGVLGPMSLFALCVIK
                     GITIENHQHILKDMYKFIMDEKFCNHERWLQRYDLISERNHFNFIRNGWCYGNTGVMTT
                     LFLIGQALQDDEIIKMSKKVMLQVVNDKDENLISPTICHGLSSQILMLTIMNLNFELNE
                     VSDYITVLINKLISHYKEDYLVNFIDINENKQDVFKSRKVGLLEGELGVYLTLMTLKNT
                     KILNEKNWTNAFLIS"
     gene            complement(11238..14231)
                     /locus_tag="NW979_RS08775"
                     /old_locus_tag="NW979_08775"
     CDS             complement(11238..14231)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500451.1"
                     /locus_tag="NW979_RS08775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08775"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_001092605.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.8e-152,
                     bitscore: 503.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.2e-13,
                     bitscore: 48.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.9e-23, bitscore:
                     79.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTIYEPSSICMIRTPLLSVEFFNLFLNTEQIKYSDLQLNAQMKE
                     SILTTTFNLYCTLQEINFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINLGHFVN
                     EPTRLKVGNSIQKYVKVDGEWLYKLVSYIESIDEYYQNLKVIWNSKAHIINDRIYLNEQ
                     SAIYLNNNKDTSFSIKNSELLVFIKTTVTNNNITFSNLAEKINQEFEINDITKVKVYIH
                     NLVSKEIIYSTIRPPLSYSDNLNYILNKLSLHNDDFVKKIREIQKLILAYEKTEIGFGE
                     ELYKDIIHHMKALFKCKNYLQIDTKIDMINNYLHQDIATNISEAAYLLWLLSRNNIGFT
                     DLKVLHNRFIEKYGFEQLVNIKDLISDITGFGTTIFQEEETDGNNIVMLKQKFLHALRN
                     NDEIVINEKDVESLINDNEINHYHAPMSADVYAELYLGRFYNQYNELIVISPLTASFNA
                     GATFGRFHHLIDTETLAKLEHEKGHYYQKMICDDNVEMISINNIPKYPRNHNVLTNHDS
                     YEYSLNLGSSNSYSKYELTLDDIYVGATFNKLYLYSSQLNKRVLFESNNMYNFLKECNL
                     YRLLREISMESVKCIEPMNDVSIDSFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEW
                     DQQFLKYQEQFNIPNIVNLVYGDNKLLLNLSLANHRYLLMKEYKKHKRVRLVESFLPQS
                     KNDHVYEIVTPIYKKSSYRGPEIEIPKYKNTDIEYDKDWFALHIHIDKPSQDTFIIDNL
                     YPFVKHLKDKGDIDQYFLMRYIKQGDILKLRLFRNDENYAEIYSILKNWLPHVRQTTEV
                     SDYEFVSYEPEFFRYGGKNTINEIEAFFEYDTNLAVNIIENDFKFDRPYIVAISIMYLF
                     EMFSISNEERMEIVNNYVPTSFKSKDIRPFKNELVTICNPANNFEYMAKHYSGIYRILK
                     DGNQILSKLNEGLKKTLTTKRSRIIGSLIHMRCNRIFGIDKDQETFVLSIVKEIVKTQK
                     HWCGDKND"
     aSDomain        complement(13521..13799)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NW979_RS08775_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.40E-15"
                     /identifier="RREFam001.1"
                     /label="NW979_RS08775"
                     /locus_tag="NW979_RS08775"
                     /protein_end="237"
                     /protein_start="144"
                     /score="48.0"
                     /tool="antismash"
                     /translation="VIWNSKAHIINDRIYLNEQSAIYLNNNKDTSFSIKNSELLVFIKT
                     TVTNNNITFSNLAEKINQEFEINDITKVKVYIHNLVSKEIIYSTIRPP"
     gene            complement(14296..14439)
                     /locus_tag="NW979_RS08780"
                     /old_locus_tag="NW979_08780"
     CDS             complement(14296..14439)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500452.1"
                     /locus_tag="NW979_RS08780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08780"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_000416756.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.1e-24, bitscore:
                     82.6, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 4.3e-12, bitscore:
                     42.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVLDLDVQVKANNNSNDSAGDERITSHSLCTPGCAKTGSFNSF
                     CC"
     CDS_motif       complement(14368..14439)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKVLDLDVQVKANNNSNDSAGDE"
                     /locus_tag="NW979_RS08780_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14296..14367)
                     /prepeptide="core"
                     /locus_tag="NW979_RS08780_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="3.40"
                     /molecular_weight="2248.6"
                     /monoisotopic_mass="2247.1"
                     /core_sequence="RITSHSLCTPGCAKTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKVLDLDVQVKANNNSNDSAGDE"
                     /leader_location="[14367:14439](-)"
                     /alternative_weights="2266.6"
                     /alternative_weights="2284.7"
                     /alternative_weights="2302.7"
     gene            complement(15176..15319)
                     /locus_tag="NW979_RS08785"
                     /old_locus_tag="NW979_08785"
     CDS             complement(15176..15319)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500452.1"
                     /locus_tag="NW979_RS08785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08785"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_000416759.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.4e-20, bitscore:
                     70.2, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 2e-07, bitscore: 28.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVLDLDVQVKGNNNTNDSAGDERITSHLFCSFGCEKTGSFNSF
                     CC"
     CDS_motif       complement(15248..15319)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKVLDLDVQVKGNNNTNDSAGDE"
                     /locus_tag="NW979_RS08785_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15176..15247)
                     /prepeptide="core"
                     /locus_tag="NW979_RS08785_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="0.40"
                     /molecular_weight="2420.8"
                     /monoisotopic_mass="2419.1"
                     /core_sequence="RITSHLFCSFGCEKTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKVLDLDVQVKGNNNTNDSAGDE"
                     /leader_location="[15247:15319](-)"
                     /alternative_weights="2438.8"
                     /alternative_weights="2456.9"
     misc_feature    15418..15435
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.94"
                     /tool="antismash"
     gene            complement(15561..16544)
                     /locus_tag="NW979_RS08790"
                     /old_locus_tag="NW979_08790"
     CDS             complement(15561..16544)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500453.1"
                     /locus_tag="NW979_RS08790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08790"
                     /product="leukocidin/hemolysin toxin family protein"
                     /protein_id="WP_072361677.1"
                     /transl_table=11
                     /translation="MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLY
                     KTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLKAAGNINSGYKKPNPKDYNYSQFYW
                     GGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNGSKS
                     FSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGG
                     RQSSSNAGQNFLPTHQMPLLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQ
                     WNRLHWIGNNYKNQNTVTFTSTYEVDWKNHTVKLIGTDSKETNPGV"
     gene            complement(16546..17481)
                     /gene="lukE"
                     /locus_tag="NW979_RS08795"
                     /old_locus_tag="NW979_08795"
     CDS             complement(16546..17481)
                     /codon_start=1
                     /gene="lukE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_114304764.1"
                     /locus_tag="NW979_RS08795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08795"
                     /product="bi-component leukocidin LukED subunit E"
                     /protein_id="WP_000473596.1"
                     /transl_table=11
                     /translation="MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRT
                     EDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQGFINSRTSFSDVKGSGYELTKRMIW
                     PFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSK
                     TISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREY
                     FAPDNQLPPLVQSGFNPSFITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAE
                     RKHNAFVNRNFVVRYEVNWKTHEIKVKGHN"
     gene            18861..18992
                     /locus_tag="NW979_RS08800"
                     /old_locus_tag="NW979_08800"
     CDS             18861..18992
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001791236.1"
                     /locus_tag="NW979_RS08800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08800"
                     /product="hypothetical protein"
                     /protein_id="WP_255200699.1"
                     /transl_table=11
                     /translation="MNCKNLAQAKTMGKPTGIANDTGKSVEEMMCRSSQVNWKIGIN"
     gene            19091..19687
                     /locus_tag="NW979_RS08805"
                     /old_locus_tag="NW979_08805"
     CDS             19091..19687
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595639.1"
                     /locus_tag="NW979_RS08805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08805"
                     /product="hypothetical protein"
                     /protein_id="WP_006190581.1"
                     /transl_table=11
                     /translation="MIKQVLRKSLNTVKEHIDKSNFQKNLIFSLVIFPFLFVPYIIIDI
                     LVHLSNNQEYFKLLSSISHIFLMFFVTAISLYAILSIALTSNSCRKSSFRKISKVIIYF
                     LVFFYILSHHINIDISKMDSSWHFYALFLCFFIISYKLTEKITKVCKWIFNEESNNDEG
                     LRTQKLFFITTVVFGTISIFSTIANVLVAIKQFLN"
     gene            19854..21200
                     /locus_tag="NW979_RS08810"
                     /old_locus_tag="NW979_08810"
     CDS             19854..21200
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711492.1"
                     /locus_tag="NW979_RS08810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08810"
                     /product="DUF4041 domain-containing protein"
                     /protein_id="WP_258413440.1"
                     /transl_table=11
                     /translation="MKKEILKKQWVIWTILVTSFFSIGTPGIAIIPFSLSIYALSKLIL
                     VNKFVEPDLVTLQNLKEKNKSINIENQKIKREIQGLKNLKNDLISSIEEGTKELEHITS
                     YLNDELFKYDIELTYPFDLVEVDSSQINTYIKKLQMKEKELLNLEEVKIFNVSTENKRH
                     QNAQAKQIIRLFNAETSQLINKVNSKNIESMQNKIFKSYEGINKIFETDNVRIPETLLD
                     IKLEMLDLMHKYQVKIEDEKIIRREERARLKEIEQAEKEMEKKLKELDKDIRHHNNEIK
                     KLTMYLNNTDLQVEKELYIEKIRELDQSLKDLNSERENVEDRKDNAQSGFVYIISNIGS
                     FGENVYKIGVTRRLEPMDRINELSSASVPFEFDVHALIFSENAFELESKLHEYFKKYKV
                     NKVNGRKEFFKVNINEIKDKVLSEHNSTVQFIDEPKAIQYRETLRLTSL"
     misc_feature    complement(21412..21428)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            21458..>21686
                     /locus_tag="NW979_RS08815"
                     /old_locus_tag="NW979_08815"
                     /pseudo=""
     CDS             21458..>21686
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000121211.1"
                     /locus_tag="NW979_RS08815"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NW979_08815"
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDNYLILTEHV"
     gene            21787..22023
                     /locus_tag="NW979_RS08820"
                     /old_locus_tag="NW979_08820"
     CDS             21787..22023
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617704.1"
                     /locus_tag="NW979_RS08820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08820"
                     /product="hypothetical protein"
                     /protein_id="WP_006190584.1"
                     /transl_table=11
                     /translation="MIRFDVNGSDHANPPNNERIPTPHIHIYTEEYNNGVIAIPLKDIE
                     DLELTDEIIESLDFFMKYTNIKHDNIIIESKLL"
     gene            22044..22820
                     /locus_tag="NW979_RS08825"
                     /old_locus_tag="NW979_08825"
     CDS             22044..22820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001561168.1"
                     /locus_tag="NW979_RS08825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08825"
                     /product="DUF1828 domain-containing protein"
                     /protein_id="WP_258413441.1"
                     /transl_table=11
                     /translation="MKTIEERMNEYFNWLKQNYIFKELDSSTEITTPLKNHLNDFIRIY
                     ADTLPNNEICLSDDGLTINELEMLGIDINTKTRTKLIQNILNQFNLKLVDKEITADVKN
                     ESFAQSKHNLIQGILKIYDLTLTTKSNVTNIFYEEVFEFLYDQKIRGLAQVSVSGESGL
                     KYSIDYIVSETKSQPEKLVNFTNNLDFNKITNEAYIYRDIKPNRPSRNKLEPIMLIIVN
                     DVDHPINERAQTVAEHENLEILKWSNKSKIIETLTS"
     gene            23218..23712
                     /locus_tag="NW979_RS08830"
                     /old_locus_tag="NW979_08830"
     CDS             23218..23712
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001253430.1"
                     /locus_tag="NW979_RS08830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NW979_08830"
                     /product="hypothetical protein"
                     /protein_id="WP_258413442.1"
                     /transl_table=11
                     /translation="MRRLFSLLLASTMILVACGNASNENKEFEDEKKSEVKKEAKKNNN
                     KPKNVKKNQDINKNNNEQVQNANNNQPVLNNNSNHNNQQQSNKNNYTVIENGNTFTEIY
                     NGQAFTTTNNPIREGYVEGETDPIYKREYKHFYTPEEAQRAQENSDQILREMGLEPERY
                     E"
     gene            <23800..>23931
                     /locus_tag="NW979_RS08835"
                     /old_locus_tag="NW979_08835"
                     /pseudo=""
     CDS             23800..>23931
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002456358.1"
                     /locus_tag="NW979_RS08835"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NW979_08835"
                     /product="Arm DNA-binding domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIKKRKSGFKTKAEASNAAQQLIRDLKDGNKIEDNKKFTAYYSD"
ORIGIN
        1 acagctgaac ctgagttgcc tggttctacg aaagcatcag taataatcat gttgccttta
       61 actgacagca cttttcctgt tgattcatac atttgaaatt tatttatata tggttctgga
      121 tagccaacaa ttgaaatgcg ttcattttct ttcgcttctg atgctatttt taaaatgcct
      181 gtgtaatctt taaaattcct gttttttgga tgaacagctt tatcttccac atgtagaatg
      241 gcaatatctt cttgacctga aaaacggaca atttttttaa ctttataaaa tccgccatta
      301 ttatattcac cattgggatg cgctataata tgtgcaccaa tttccatacc tgcaacgaca
      361 tgcttgttgg taacaattgt atttttaccg acaatgaaac ctgttccaga tcctatcgaa
      421 acgataccat tgtatggtgc tacattagta tttttgatta gtttcacatt atgttcggct
      481 ttagccgttt gttgaatacc ctcaaccact gttgtgccga cgccagtcac tgatgttaaa
      541 atcgtcaatg ctgcaatact tttgatgatt atatttttat tcatttttgt gctcctctaa
      601 gtattcgtat aaatataagg ttaggttttt gaagttttat tttttaaatc atttcgaata
      661 aatagaatca cagagatgtt taaaattgtt gattttgttg ttaatttcta aaaatcattt
      721 atcaatgtat ggatggatga tttatttatc taaattatct gcaataaatt tcttaatttc
      781 aggagagaaa taaacagcaa atgaccttgt actttcacct gttggtttat cactagcata
      841 cataacacca attgcttctc gcttactatt taatataggt gaaccagagc tgccaggttg
      901 gacaaccgca tcagatgtca ctatatttcc attcactgat agtactttac cagttgattc
      961 atacatttgt agtttatttc cattaggatt tggataacca atgactgata taggttcatt
     1021 ttctttagcc tctgatgcta tattaaattt gctagtgaaa tctttgaatt ttctaccttt
     1081 tggttgtgtt gatttttctt caacttgtac gaccgcaata tcttctttac caggataatc
     1141 tacaatctta gtaactttat aaagtccacc accgttatta taaaaaccat taggatgtgc
     1201 tttgatttca tcaccgactt tcatgtgata ggtaacatgt ttattggtaa tgattgtatg
     1261 atttccaact acaaatcctg ttccagcgcc catccatgta acaccactgt atggtgcaac
     1321 atttgtattt gtaatttgtt taacagtatt ttcggctttg gctgtttgtt gaataccttc
     1381 aaccattgtt gtgccgacac cagttattga tgttaaaatc gtcaatgctg caatactttt
     1441 gatgattata tttttattca tttttctgct cctctgttta ttcatgatgc ttttgatata
     1501 gacgtttttt tatgttatat tcgaccgatg tttttcatta aaattattga acacatgctc
     1561 atggtgtata tttacatttg tttattgttc aatgtgctta tgaataaaat ctttgatttg
     1621 aggcgtaaag tatacggcac cattatattc agaaccaatt tttccaatac cgccatacac
     1681 cacacctatg acctcattgt tagaatttag aactggtgat cctgaattgc cgggttcaat
     1741 gtatgcatca aaatttaaaa tattgtcttt gattcttttt atagttcctg tagattcaaa
     1801 ctgtttaaaa ctattttgag caggtaatgg gtaaccaata actttaattt tgtcatcaac
     1861 tttagcatct ttcgcaaaat tgaatgcttg gacattttca ttaaaattaa agccttttgg
     1921 tccacgttca actgcttgtt cttcaatatt catgacagag atgtcttcat cacccggata
     1981 atcagaaatg cttttaattt tatatatacc accgtttcct ttgtcaccgt ttggatgggc
     2041 agtaattcta tcgccaactt tataatcttt tgatacatgt ttattagtga taattgtatt
     2101 ttttccaatt acaaaacctg tcgcatcttt aaatgaaacg acgccattat atggaaaaat
     2161 atttgtatct ttaacttgcg taacattctt ctctgcattt gctatttgtt gtgtctcttc
     2221 aacgactgca gcatttattc cagttactga ggttagaatg gctaatgctg ccatgctttt
     2281 aatgactata tttttattca ttttcaagct cctttacaat tcgagatatg ttgcaacgct
     2341 cgtttaaagt caatttgttt atttatctat gttttctgca atgaattttt taatttctgg
     2401 tgtaaagtag acgccatatg catttctgtt atcatcattt tttacatcag aagcaaaatg
     2461 aataccaact aattcgttgt tgctgtttaa tacaggtgat ccagagtttc cgctttcagt
     2521 atgcgctgaa tatacaatac tactaccttc tactgacatc acagggccag ttgactcata
     2581 taaaacatat ttatttttgt atgggtgtgg ataaccaatc actttaattc gctcaccagc
     2641 tttagcccct gccgcatatt tgaatggcgt tacattatca ttaaaattaa agccttttgg
     2701 tccacgttct attgcacgct cttcaacttg aatgactgat acatcttctt tacctggata
     2761 attaataatc tttttaatcg aataaatacc accattacct ttatcactat ttggatgtgc
     2821 agtaatacga tcgcccactt tgtaattttt cgacacatgt ttatttgtta aaatagtatt
     2881 ctttccaact acaaatccag ttgcactttt aaaagcaact acaccagtat atggaaaaat
     2941 attagtatct ttaacttttg tgacattatt ttctgctttg gcagtttgtt gaacttcctc
     3001 aaccaatgtt gttccaatac ctgttacaga tgttaaaatt gttaatgctg ctaaactctt
     3061 gatgactacg tttttgttca ttttaagttc ctctttttta attattttga tatctagata
     3121 cataattcag tatatttagt taattatgta accgttttct taaccattct ttaaaaaatc
     3181 aacttcacga atgaattgat gatacttatt tttcaatatt attttgtata aattctttta
     3241 attgtgtgtg aaataaacac cgaaattctt ttcagattca tcttttccac tacctgcata
     3301 taaaatacca atcagttcat gtttagaatt caatacaggt gattcagagt tccctggttg
     3361 cgcaaacgca tcaaattcca taaatgttcc attgatacga ttaatcgttc ctgtcgattc
     3421 aaacatttta tattttgttt gtgcaccctt tggataaccg ataacagaat ttctgtcttt
     3481 catttttgct ccgtctgcaa attttgtata actaacgttc ttattaaaat tcaaaccttc
     3541 tgtacttgtt tcatgaacat gaactatcgc aaggtcttct tttccgagat attctacaat
     3601 gtctttaacg tcgtagtttc ctccgccttt acctttactc aaatgatgtg ctgatactct
     3661 atttttgaaa atatcattac ttttagcgat atgtttgtta gttacgattg tatttttacc
     3721 aacaactaca ccagtaccac ccgcaaatgc taccactgaa ttgtatggtg ccttagttgc
     3781 atcggtaatt tctttgacat tcttttctgc tttggcaatt gaatgaggct gatcagaaat
     3841 attttcagcg aaaccaagag atgttaaaat agttaaagca gttaaacttt taaccattac
     3901 atttttattt atattttacc tcctttaaaa tttattttta tagttaatgt atctagatac
     3961 acattcacta tatacatttt atataaaaat attaattaaa tattaattaa ctacttatta
     4021 acattttatt aaataattat acatgaattg actcatttat ttaaatatgc ttaaaactca
     4081 atatcacgca attaaaattg gcatttttgg attattttgg tcttaaatat taattattga
     4141 attaaaattg taatatttat tcggaaatta ggttagtgtg aatatatggc ggaatggtga
     4201 acaattcacg tatttataat ctttcacttt attatgtatt gtgtttaaca atattattag
     4261 cgattagttc ccctattatt tatgacaata tgcagtcaat caatgaaaca tgtatgtatg
     4321 agtatatttg gaactagtaa tgtattgtta attattgaag atgattgaat tatggaattt
     4381 ttttcgagat atgttatttc ggggatcaga ttttgcgatt ttgccttgga tagagtagtt
     4441 gcgatttgta aatacgtttt acaggttcga ttcaatttcg ttgttaagat aatatggatt
     4501 agtttcactg acatgttgat gcatgtcttt tttgttctga taaagtgtaa aatgtttact
     4561 taacattact tagtatgaca cctgctaatt caaacattat ttgagacatt cttttcaaat
     4621 taattataaa tttttaccta tagactagtt tgatatttat ctacatccca aaattctcat
     4681 caacaatctt tcacatccaa catttttact ttagttttta taattcaaaa caacaaaact
     4741 atgttaaaaa attattctat tttttagtta atagatagtt aataaatttt tgatatttag
     4801 ttaattgttc ttttaaaaaa ttattattat attttcattg taaacgttta caatataaaa
     4861 aaaggagcaa ttaaaatgaa tacaaaattt ttaggtaaaa cattagtagc aagtgcttta
     4921 gtattaacaa cattaggaac aggcttacat tcttcatact taggattaga tacaaataaa
     4981 attgttaaaa cagctaaagc agaagaaaaa atgacagatg gtcaattatg gaaaaaagtt
     5041 aaagattcat tacatgattc tgatattatt ttaagtaacg agtacgaaac aatcaacgtt
     5101 acttatttat taagcaatgg atattctagc agcgtttctg ctcctggaaa tgatgatgga
     5161 ggccatctaa cacaatctat agactttaaa ggattaaaac aaattgattt aactaaggaa
     5221 aatgtctacg atgactttaa caaaaagcta gatgctaaaa atacatggaa ttctctaacc
     5281 gagaagttaa aaggtcttgg tttactacaa aatggccaaa aagtatctat ttattcttca
     5341 gatagctctt ctccagtctc gggtaaagtg ggagaaggag taactagtgg tggcgaaaat
     5401 actctaacta aacgcttcat caacaaaatc acaattgatt aaaccttaaa ctcaaatttc
     5461 cttaattcat aaaacattaa taactaaccc tttcttacaa accacctagc ccataatata
     5521 ttaaaacgtc atttttattt caattagcgg aaaataaaaa aaccattccg cattaacttt
     5581 ggcaagttgg aatggttaaa aaaatatttt agaagccagc gtttggcttg cttagacgac
     5641 atgttcgcgc atgtcgtctt atttttacat ttatataata acacgcaatt caataaaatg
     5701 tctaatcaat aaacctcaat tacattcaaa ttcaaaaact tttcacctaa tattcatcgc
     5761 ttaaataaac attacgttta attaaacaga cattgtcaat cgcgtctaat acccctgctg
     5821 tccgaaaaca aaattatttt gtattcatat ttaactgttc tctttcctcc cttttcaacg
     5881 caactaaatt tcttttaccg ttagagcccc aatctttaat ctttaattgt tctaccgctc
     5941 catttattaa atcctttaaa gagtaaaact gctaatagca acgtgataat aatatagatt
     6001 gccaatgtta atgtaactgg tatactccct tcgataaaca tataaacgta acgtgtagca
     6061 tatgtgattg gtaaatagaa ccacgaatga tctccaagca cttctaatcc aaaataaacg
     6121 ttaaaaataa acattaaaac tccgacaaca atagccatta catctttaat gaaaatacta
     6181 aaaataaaaa gtagcagtaa tataattaca ttgaaaaaca atgatacgcc tataaacata
     6241 agtgttattt tcatatcatg tgaatgccac aataaattaa ttgatgctaa tagaatacat
     6301 atggctgtaa tagtataagt aaaaatcatt gatgcattta accaatttag cctattagct
     6361 tttcctaaaa tatgattaaa gtgaccaata ttttcttcaa aattgataac ttgatagacg
     6421 tttatagaaa ttaatagcga tgtaattgca ttaaaactcg ctgtaaacaa acttatttgt
     6481 cgaccattcc ataaatttac gtttaaatac caatttataa ataatataaa caatatggtt
     6541 acaataatgg gtacaaatgt gagcgcttgc ttagaaaatt tcaacttaca tgactttaat
     6601 tcgttaatta tcattttaat cgccaacttt tcttattatt taaaaatgtt actatcgcga
     6661 aaataatgat gctaacaata atcgaaatat ataaggcatt gagatcatta aagtattttg
     6721 aattatggtt tacaactaaa ccattaggta gtataccaag cgtaataagc gggattctct
     6781 gcattatccc ccacggcaac acccaaaata aactcttcaa tgttaaaaac aagacacaaa
     6841 tgactgataa tactaagttt attaatattg atacgaacac accaaagtat cgagttaata
     6901 aaaagttgag cggtatcaat ggtagagata ctacatacat caacaatatt gtcaccaata
     6961 acaacatagc attaaccgga tgtggattaa taattaggtc acctatataa gcaataataa
     7021 atactaaaaa gcaatgtacc aaaaatgcta ttgataaaat gaaaatcttt gctcttattt
     7081 cttttgtaat cgaccaatta ttacttaagt aataattaaa tgatttattt ctcatttcaa
     7141 ttttaaataa cgaattacaa gccatacata atacaatcgg gatgaaagca attggccaaa
     7201 tattaaatag taaagttata tatggtgaca cactattcgc tgttcccgta ttacttttgg
     7261 cgaataagac tgtgaaaata gcaaaacaaa gaaataccag cggacttatt aataaaacat
     7321 acatactgaa agaattttta aatttgatac cttctatctt taaatgtatc atttgtaatc
     7381 acctttcgtt attttgaaga atatctcttc taagttttca tctttgttat ttctttgctg
     7441 atattttagc tcaccctcat gaataatacc gatatgatct gctaaaactt ggatttcaga
     7501 taaaatgtga cttgaaataa taatactagt accttgttct gttaataatt ttagaagttc
     7561 tctaagttct tggattccat atgggtctaa accattagat ggttcgtcta atactaaaat
     7621 ttctggcttt ttaattaatg ccattgcaat tccaagtctt tgtttcatac ctaaagaaaa
     7681 gtccttaacc tttttctttt tatcgacatt taaattgact aagcttaaaa cactattaat
     7741 ttcgctgaaa tcaacgcttt catttaaaca cacaattttc aaattatctt gtgcacttaa
     7801 atgattatat gtcgcaggtg tttcaataag cgaaccaact ttgtgcaaat catttcgtgt
     7861 cattggtcta ttatctaatt taatttcccc tgaatcttgt tgaagtatgc cacatataat
     7921 tttcataagt gtcgttttac cggctccatt aataccaagt aatccataaa cttcgttatt
     7981 ttctaaagtg atattaatat gctttaatac atcttgattt ttaaaccgct tcgaaatgtt
     8041 ttcagtaact aattttgcca taatcaaaaa ctcctttgat ttattaactt gctttttgat
     8101 ttgctacatt taatgcttta tacacatcaa gctcaccatg cccatatcta ctaaatggtt
     8161 tattattctt agatgtccca tgctgatata acaattcaat cgctttatct ggatgttttt
     8221 caagatgata tttatcaatg attaaagcta gtgctcccga aactttaggt gtggctaatg
     8281 aagttccagc ttgataaata tatcttccgt tattggcagt agttaaaatg ttctccttat
     8341 gcatataccc ttcattcatc catttatcca caccgaattg atttaaataa gcaaatgatc
     8401 ctccgggcgc agcaatatct gtataattca taccaaaatt ggaaaactca gatagattac
     8461 tcttttgatc tgtagatcct actgtaacga cattgtccat agatgcagga acatctttca
     8521 cttcgccatt accttgatat tcacgctgta attttagttt ctgtttgtca ttgacatcaa
     8581 taccatcatt accagctgca gcaacaacga tagatttttt cttcttggcg taattgattg
     8641 ctttctgtaa cgcatcgtat tctacttttt catcttttct aaatgtttga tggtcatttt
     8701 tgtccaaaat aatataacta ccaacactaa tattaatgac ttgatttcca tcatttgcag
     8761 cttgaacaat cgcttttgat acccaaagca gttctgtttt tttactacca aacacgcgat
     8821 acattgtaaa tttgttattc ggtgcaacac ctattaactt accattagca ctcgtttgac
     8881 ccgacaccat cgtgccatgt cctttcctat cattgacatc gtgaacatca cctgtttcct
     8941 ccggttcagt acctctaaaa ccgtttaaag gtactaaatt tttagaatca gtcgagaaat
     9001 tatttttcaa atcgtcatgg tttttcatca cacctgtatc tatgattgct attttggtgt
     9061 tagcatgttt tggcaaatca tcatacgatg caccattatt ggttatttta ttcatatccc
     9121 attgtcttga aaataatgac tcatttgatg ttctgtctat tgttttctcg ctagtaatac
     9181 aagttgaaca tgtggcattg atatatttaa tatcattttt atagtttgct aaagcattag
     9241 catgcatttt cgtcatttta atctgtgcca catgtaattc cggtatatta tagacaacgt
     9301 ttaaggactt ctttttaact aacttgttaa atgttgctgt atttttgtat tcaacactgt
     9361 aatatagttc ttctgacgct gatgcattac tcattgtaat agatattaaa agactcaata
     9421 ttattaaact aataatagcg cgctttatga ttttcatatt ctaatctcaa atgaattcca
     9481 gaactttata tggttcaggt gcgacaacat tctttttaaa tgtttttgac gctaattcat
     9541 aactttctga aatatttgct ggatatattg atacaccata atcttttaat aatcgaatat
     9601 tattttgagt aactggattt tcccacattc gtaaattcat atttggaaat atagaaagtt
     9661 tttcaaaagc tgtatgacaa atagttaata ataaattgtc acatatacca tttgcaattt
     9721 tattaatcgt attagaagtc gcaggtaaaa taataatctt gtcatgttta tttgctatat
     9781 ctacatgatt taaaaaaggg tcttcaaatt cgtcataata gttatcgcaa aattgcttta
     9841 atatttcacc attaataaac tttctaccgt ttgttgacgc gattacattt acttcatcaa
     9901 attttgattt taattcaata atatagtggc taatattgat actattaact gagccacaca
     9961 aacaaatcaa tacattttct cccatgatat acgcctccat tcagctaatt aaaaacgcat
    10021 tggtccaatt tttttcattg agaatttttg tatttttcag tgtcatcaat gttagataga
    10081 cccctaattc accttctaaa aggccaactt tcctactttt aaatacatct tgcttatttt
    10141 cattaatgtc tataaaattc accagataat cttccttata atgagaaatc agtttattta
    10201 ttaatacagt gatataatca gacacttcat ttaattcaaa attcaaattc ataattgtta
    10261 acattaatat ttgtgatgac aatccatgac aaatagttgg acttattaaa ttttcatctt
    10321 tatcatttac tacttgtagc atcacttttt tagacatttt aattatttca tcatcttgta
    10381 atgcttggcc gattaaaaac aacgtcgtca ttacacccgt attgccataa caccaaccat
    10441 tccgaataaa attgaaatga ttacgttcag aaattaaatc gtaacgctgc aaccatcttt
    10501 cgtggttaca aaatttttcg tccatgataa atttgtacat gtcttttaat atgtgctgat
    10561 gattttcaat cgtaattcct ttaatcacgc ataatgcaaa taaagacatc ggtcctagca
    10621 ctccatgtgc aaggccaaga ttgatattac cttcagtaaa ataattttta tcagactcta
    10681 aaaattgact ttcttgtggg actacccagc tatttttaga atattgaata tctttaaagt
    10741 atactaatat gctttttaat gctttaacat taaattcatt ctcatctact ctatttagca
    10801 aatatcttcc tatcccagct aatccactga cagtatcata atttaatgga tttaatggtt
    10861 cttgtaatat ttgatcaaat ttattttcta tttcatttac aatgtgacca tcaatattat
    10921 ttaaaatatt ttgataattt ttgccatttt gcgatgctaa atccattgaa aatgcaatac
    10981 ctgaaagtcc accaaacaaa gaattgttat attgaccact ctgtaaatat ggtgctaatt
    11041 tcatgatgta cttatgcaca atttgctcag tattaatatc gaaaactttt tgataagcat
    11101 ctaaaaacaa aatgatacct ggtataccat gtgataaagt tgaaggttca aaataatcgg
    11161 tttcagtaga tgcttttgaa atgaaatcat ctacttctga aatctcttga aacttcttct
    11221 tcaatattag attcatatca atcatttttg tcaccacacc aatgcttttg agttttaaca
    11281 atttctttta caatagataa aacaaatgtt tcttgatcct tatcaatgcc aaatattcga
    11341 ttgcagcgca tatgaattaa gctgccaata atccttgacc ttttagtagt taaagttttt
    11401 ttaagccctt catttaattt gctcaaaatt tggttgccat cttttaaaat tcgataaata
    11461 ccactatagt gtttagccat atattcaaaa ttattagcag gattacatat agttacaagt
    11521 tcatttttaa aaggtctaat atctttactt ttaaatgatg taggtacata gttattaaca
    11581 atttccatac gctcttcatt agaaattgaa aacatctcaa ataaatacat tattgaaata
    11641 gcaacaatat atggtcgatc aaacttaaaa tcattttcaa taatattgac agctaaattc
    11701 gtgtcatatt caaagaaggc ttctatttca ttaatcgtgt tctttccacc atatctaaaa
    11761 aattctggct cgtatgatac aaattcataa tctgaaactt ctgtcgtttg tcgaacatgt
    11821 ggtaaccaat tcttcaagat gctgtatatt tctgcgtaat tttcgtcatt cctgaataac
    11881 ctcaacttta aaatgtcacc ttgtttgata taacgcatta aaaaatattg atctatatct
    11941 cccttatctt taagatgttt tacaaatgga tacaaattgt cgatgataaa tgtatcttgc
    12001 gatggcttat cgatatgaat atgtaatgca aaccagtctt tgtcatattc aatatctgta
    12061 tttttatatt ttggaatttc gatttcgggt cctcgataag atgatttttt ataaattggt
    12121 gtaacaattt catacacatg atcattcttt gattgaggta aaaatgattc tactaaacgt
    12181 acacgtttat gcttcttata ttctttcatc aataaatatc tatgattagc taatgataaa
    12241 tttagtagaa gcttgttatc tccataaact aaattcacga tattaggtat attgaattgt
    12301 tcttgatatt tcaaaaattg ttgatcccat tcttcatttt taggtaaagg taataccatc
    12361 tcgttaattt tccaatatgc tggtttaaga atgacatttt tatatctgat tcgtggtgaa
    12421 taactaaatg aatcaatact cacatcattc ataggttcaa tgcatttcac agattccatt
    12481 gaaatttctc gtaacaatcg atataaatta cattctttta aaaagttata catattgttt
    12541 gattcaaata gtaccctttt atttagttgg ctagaatata aatataattt gttaaaggta
    12601 gcaccaacat aaatatcatc taaggtaagc tcatactttg aataactatt actacttcct
    12661 aaattcaatg aatattcgta tgagtcatga ttagttaata cattatgatt tctcggatat
    12721 ttcggtatgt tatttataga aatcatttct acattgtcat cacatatcat cttctgataa
    12781 taatgtcctt tttcatgttc taattttgct aaagtttcag tatcaattaa atgatgaaat
    12841 cgcccaaatg tagcgccagc attaaaagac gccgttaaag gactaataac aatgagctca
    12901 ttgtactgat tgtaaaaacg tcctaaataa agttcagcat aaacatctgc actcattggc
    12961 gcatgataat gattgatttc attatcgtta atcaatgact ctacatcttt ttcatttatg
    13021 actatctcat cgttatttct caaggcatgt aaaaattttt gcttaagcat tacaatatta
    13081 tttccatcgg tttcttcttc ttgaaaaatt gttgtcccga aacctgttat atctgaaatc
    13141 aaatctttaa tattcacgag ttgttcaaat ccatactttt caataaaacg gttgtgaaga
    13201 actttcaaat ctgtgaatcc aatattattt cttgataaaa gccacaataa gtacgctgct
    13261 tcagatatat ttgttgctat atcttgatgt aaataattgt taatcatgtc aattttggta
    13321 tcaatttgaa gatagttttt acatttgaat agtgccttca tatgatgaat aatgtcttta
    13381 tataattcct cgccaaatcc aatttcagtt ttttcataag ctaatatcaa tttctggatt
    13441 tctctaattt ttttcacaaa atcatcatta tgtaaagaaa gtttatttaa aatataattt
    13501 aaattatcgc tatatgataa cggtggtctg attgttgaat atataatttc ctttgagaca
    13561 agattatgga tatatacttt cactttagta atatcattaa tttcaaattc ttgatttatc
    13621 ttttcagcta aatttgaaaa agtaatatta ttattcgtca cagtggtttt gatgaatacg
    13681 agtaattcgc tatttttaat ggaaaaagat gtatctttat tgttgtttaa ataaatagca
    13741 ctttgttcat ttaaatatat tcgatcattg ataatatgtg ctttactatt ccaaataact
    13801 ttcaaatttt gataatattc atcaatactc tcaatataac taaccagttt atacaaccat
    13861 tcgccatcga ctttcacata tttttgaata ctatttccaa ctttaagacg tgttggttca
    13921 tttacaaaat gccccaaatt aataccactt aataatccaa atggagttgg acgtgttgac
    13981 attctaatta aatattttaa taaactttct ttagcatctc taaccttctt gttatcgcca
    14041 tcaaaattta tttcttgtaa agtacaatat aagttaaatg ttgttgttag gattgattct
    14101 ttcatctgag catttaattg taagtcgcta tatttaattt gttcagtatt taaaaataaa
    14161 ttgaaaaatt caactgataa taaaggtgtt ctaatcatac aaatacttga cggttcgtaa
    14221 atagtgttca tttgtaagca cctcacatat ttgaatagac aaatagagcc ctttcaggct
    14281 ctatttgctg taatcttaac agcagaagct attaaaacta ccagtcttag cacaaccagg
    14341 agtacataaa ctatgacttg taatacgttc gtcacctgct gaatcatttg agttattgtt
    14401 tgctttaact tgcacgtcta aatcaagaac tttttccata gataaaacct cctattatta
    14461 gttgaagtta aggcctactt caattgtcat attatccctt ttcacacaac aaatcaataa
    14521 attatataat tatattttgt gaattttttg taaacactta ttaatttagt aatactattt
    14581 tgataattag atttttgtgt ttttttatta ctatttattt tcactaataa ttttgcatct
    14641 aagttcataa ttttaaattt attgatgaat tttttaatag attaatcaat tcatttatac
    14701 aaatacttag atatttttat ctatcaatac tattacgaat ttggagatgg ctgcttgaga
    14761 ttaattaata gatatttatg cagttttgtt ctatttatac aaaatttagc aaataataat
    14821 tgaagttatt ttaaagatga ggatataaac atataatttc aatgacttga ttattttctt
    14881 aaatgacatg ttctaagagg gtcaatataa taaccaaagc ttgtcattac ttatatgtaa
    14941 agatagaggc taattacata atcctaactt atttaacagg aagtcatgaa aactatatta
    15001 caactaaaag tataactttc catcaccaaa gtcagaattt attgaaacac tcaactgata
    15061 atatagaagg ctaattataa aaatacctgg cgattaataa actgtttccg ttttttagca
    15121 cttaatatat ttaaaaagac aaatagagcc ctttcaggct ctatttgctg tatccttaac
    15181 aacagaagct gttaaaacta cccgtctttt cacaaccaaa gctacaaaaa agatggctag
    15241 ttattctttc gtcacccgct gaatcattag tgttgttatt tcctttaact tgcacgtcta
    15301 aatcaagaac tttttccaaa gataaaaccc cctatttaaa agttgaagtt aagacccact
    15361 tcaattgtca tattaatcat taccacacaa taaatcaatg aatttaataa taattatttg
    15421 ttattaattt gtaaatcgtc attaatttta tggtactatt gttagtttaa acaaataatg
    15481 taacttcttt ttttaatatg ttgtgaatat tttttgttta actcttaaat ttcgggttta
    15541 acttcctcta tttctaacag ttatactcca ggattagttt ctttagaatc cgtaccgatt
    15601 aatttaacag tatggttttt ccagtcaact tcataagtag atgtaaacgt tactgtattt
    15661 tgatttttgt agttattacc aatccagtgc aatcgattcc attgattagt atatctatcc
    15721 atttctcttt ggtaagttac tttgatttta gatttttttg tatcattttg tttatgagaa
    15781 agtacgctta taaattctgg gttaaagtta ccacgcgcca ataaaggcat ttgatgtgtt
    15841 ggcaagaaat tttgtccagc atttgaacta ctttgtctac cacctaaaaa cagttcatta
    15901 ccatatgttg ggtcataact atctctacca tatggtcccc aaccattatt cataattttg
    15961 tgcgcctcaa caccccagcc aattgattta tgatttgttt ttctatcaat cgtagttctg
    16021 taactttctt gtttataatt tatcgtttct gaaaatgatt ttgatccatt taatccacct
    16081 gataagccat tagatatatt aatatctccg ccataagaat aacctaatgt ttgttgaact
    16141 tggaattctt cattttgatt tttaggtgca tagtcaacaa catttacagc atcatttgat
    16201 tctgaactaa ccgaaacatt atacttaccg ccccaataaa actgtgagta attgtaatct
    16261 tttggattag gctttttata acctgaatta atgtttccgg ctgccttaag tactaacgta
    16321 tctttgtcat aacttttatc cttaatgaaa ttaaacgtta aaatttgaga aatattcaat
    16381 ttatcattat cagatgttgc tgttgttttg tataaagtga ttttgtcatc tacttttttc
    16441 tcgcttacag gtgtgatatg ttgagctgca tcaactgtat tcgatagcaa aagcagtgca
    16501 attgatgaag caactgatga tttgactaat tttttcattt tcatattaat tatgtccttt
    16561 cactttaatt tcgtgtgttt tccaattaac ttcatatcta actacaaagt ttctatttac
    16621 aaatgcatta tgctttcttt ctgcgtaaat accagttcta gggaataaag tcgcatatgt
    16681 aatatctaag tttctaccat atgaaatttc aaattcactc gtatcacttg aacctttttc
    16741 atgtgatagt gtagtgataa atgatggatt aaagccactt tgaactaaag gtggcaattg
    16801 attatcagga gcaaaatatt ctcttgctga acctgttgga ccatttggac tttgtacgaa
    16861 taaatatcta tcatgcgcag attttttacc atcaggcgta acaaattcgt ttgctttaac
    16921 accccattta acagattttg agttttgctt gtctacttca ctgacataac tcttttgggt
    16981 ataactaatt gttttagaat aattaaatga gccattgcca cctatagatg gtgctgactg
    17041 gaaattacct ccaatgttat atcctaatgt ttgaccaaca tcagtagttt ctattttgtt
    17101 tttaggaagg taattgatta agctaacatt tggatcttta gtcgtcagtc ctatattata
    17161 ttggaatggc caaatcattc gtttagttaa ttcatatcca ctacccttca catctgaaaa
    17221 tgaagttctg gaattgataa aaccttgcat tttaacaatt aaagcgtctt tgttatattt
    17281 tttatctttt acaaagtcga attggacatt ttgagtaacg ccccatttct tactacttac
    17341 atcctccgta cgtttgatta cttcagcacc atcaccaata ttttcaatat tagtatttgc
    17401 tctagattct tgaatcggag atgctaaagg tgcaatcagt cctactgaca aagttgcggc
    17461 taacattttt ttcttaaaca taagtttcac tttctttcta tataaatttt taatacaaat
    17521 ttattctaga ttatttcact tatttataaa attaactgtt cattaaaaaa taaaatgcta
    17581 taaaatatta aaaatgacat aatttattca tttatgctgc tgaaaaccgg tcattttgat
    17641 gcaaccttca ttacatttaa atagttccct ttatactcga acaatatgat aaaattaccg
    17701 atactcaact ttttcgctat aaaaatcaaa acgaacttta atcaaatctt aaaaaataat
    17761 gtttgtatta tcacaaataa tctataattg aatttaaaat taactgatta ttaactatta
    17821 tccgttaaat ggagaggatt acttcgtata ctgttataac tgaaatcttc tatatatcat
    17881 ttcgtaatat cgctagcttc atctaaaaaa tttaatgcta tgatttagcc gaattaaaaa
    17941 catatatact tatttactat gaactaaaag tttatcctaa aaataaaaaa ccatgatttc
    18001 gaagtcttca taaactgaag cttctactct catggcaatt tatactatga tattcaatta
    18061 taatgcctag tctcatagta aacggctact acattcgcat gtacttcgtt ttactgtcca
    18121 cgcatggtcg ttgacttatt tatattataa tataaatatt ttatttttca atacttaatt
    18181 ttaaaaatcc cctatgaaaa tggagatgag ctgcatcttt aaaccttatt ataccttgta
    18241 tgaaaaacat attgtggaat gctaatttaa caatgtacac tttttgttgt gtatgtatgt
    18301 cgcaattctc cctatcatga ctattattcc gtataattat aatattaatt atcgacttga
    18361 aaagttataa acataagtgt caaataatgc taattatggt aagttaatat tacatttagt
    18421 aacatcaaag ttaacaaata tagaagaaaa tcctcaactt tctaattatg aatcagaata
    18481 ttatcttctt gaaaaaaatt taattaagac acaatttatc aaaagtacta aaagtagaag
    18541 tctatatgaa gaaaccactt atcacaaatt gacgaatgga gacatcttaa accaacccgg
    18601 aactttgaaa ttatggacgt aggcatggct ttagtccaac cgtttcattg catgaatttg
    18661 gaaaaacatg tcagatacct atttgaaatt accgaatatt tacatttaag taaatcataa
    18721 attttagaag tattatgata atatatacca ttaaaaccaa ttactaattc attgttctaa
    18781 ttatgcaggt aactttccgc aataagtcca aaataaatct aatggataaa aaataatcaa
    18841 aactttaact ttaatcaata ttgaactgca aaaatttggc acaagctaaa acaatgggta
    18901 aaccgacagg gattgccaat gacacaggta aatcagtaga agaaatgatg tgtagaagtt
    18961 cacaagtaaa ctggaaaata gggattaatt aaaattcgtt tcaaccttta tacatactaa
    19021 gcaaaattac acactttata aaaataatat taattttgta aaattcagct tatttggagg
    19081 attaatagca atgataaaac aggttctaag aaaaagttta aatacagtaa aagaacatat
    19141 cgataaaagt aacttccaaa aaaacttaat attttcactt gtcatattcc cattcttatt
    19201 tgtgccttac attataatag atatactcgt acatttatct aataatcaag aatactttaa
    19261 gttattatca tctatttcac atatattttt aatgttcttt gtaacagcaa taagtctata
    19321 cgctatactt tctatagctt taacatctaa ttcatgtagg aaatctagct ttagaaagat
    19381 tagtaaagta ataatttatt ttttagtatt tttttatatc ctaagccatc atatcaatat
    19441 agatatttct aaaatggact cttcttggca tttttatgcg ctttttttat gtttttttat
    19501 tatttcatat aaattaactg aaaaaataac gaaggtatgc aaatggatat ttaatgaaga
    19561 atcaaataac gatgaaggtt taagaactca aaaattattt tttataacga ctgtggtttt
    19621 tggtacaata agtatcttct caacaattgc aaacgtttta gtagcaataa aacaatttct
    19681 aaattagtta tatcaattaa ataataaaag gtagcaaaaa ttatatagta aaagtgatag
    19741 tagattatta aaaaaatata tatcatttgt tgtcactgcg tcaaaactct aaagcaatta
    19801 agccatcgag agtatttaaa tacacataaa ttcaaattaa ggagaatagg taaatgaaaa
    19861 aagaaatttt aaaaaagcaa tgggtaatat ggacaatctt agtaacatct ttctttagta
    19921 taggcacacc aggtatagca ataatcccgt tcagtttatc aatatatgca ttatctaaat
    19981 taatacttgt taataaattt gtagaacccg atttagtaac acttcaaaac ttgaaagaaa
    20041 aaaataaaag tatcaacatt gaaaatcaaa aaatcaagcg tgaaatacaa ggattgaaga
    20101 atctaaaaaa tgatttaata tctagtatag aagaaggtac taaagaactt gaacacatta
    20161 ctagttattt aaatgatgaa ttatttaaat atgatataga attaacttat cccttcgatt
    20221 tagttgaagt agactcatct caaattaata catatattaa aaaattacaa atgaaagaaa
    20281 aagaattact aaatcttgaa gaagtgaaaa tatttaatgt ttctacagag aataagagac
    20341 atcaaaatgc acaggccaag caaataatac gattatttaa tgctgaaact tctcaattaa
    20401 ttaataaagt aaatagcaaa aatatcgaaa gcatgcagaa caaaatattt aaaagttatg
    20461 aagggataaa taaaatattt gaaacggata atgtacgtat tcctgaaact ttacttgaca
    20521 taaaacttga gatgttagat ttaatgcaca aatatcaagt taagatagaa gatgaaaaaa
    20581 tcataagaag agaagaacga gctagactga aagaaataga acaagcagaa aaagaaatgg
    20641 agaaaaaact aaaagagctt gataaagaca ttagacacca caataatgaa atcaaaaagc
    20701 tgacaatgta tttaaataac acagatttac aagtcgaaaa agaattatat attgaaaaga
    20761 ttagagaatt agatcaatca ctcaaggatt taaattctga aagagaaaat gtagaggaca
    20821 gaaaagataa tgctcaatca gggtttgttt atataatatc aaatatcggt tcatttggag
    20881 aaaatgttta taagattggt gtaacccgta gattagaacc aatggataga attaatgaat
    20941 taagtagcgc atctgttccc tttgaattcg atgtgcacgc tttaattttc tctgaaaatg
    21001 cttttgagct tgaaagcaaa ttacacgaat actttaaaaa atataaagtt aataaagtta
    21061 acggaagaaa agaattcttt aaagttaata ttaatgaaat taaagataaa gttttatcag
    21121 aacacaatag cacagttcaa ttcattgatg aaccaaaagc tatacaatac agagaaactt
    21181 taagattaac ttcactctaa aaataagggt agcccgccta cccttattat tttttgccaa
    21241 cttttatgag tatgttatat atcaataaaa aaacaaccaa attgtaaaag gttttatggt
    21301 tttggatagg aatgtaatta ttgaaaaaag taattattta ttaatcaata cattgtaata
    21361 ttaagtgcaa cccaataaaa attcataaaa atacccacga tgagcacttt attgtaaggt
    21421 gtttacaacc acgaaaacac atttaagtat tgccaatatg agcgataact atcttatact
    21481 aactgagcac gtatagagaa aattattctt taagacctat tgcacgtaaa ttagaacgat
    21541 ccgcatctac tatcttacgt gaaattagca gaaataatgt aaataagtta tatcaagctg
    21601 aaacggctca aaagaattat gtaactacaa gaaaactttg tggtcatcct actggattta
    21661 ctccagaact tagcaatatc attaagtaaa atttaaaaat accactactc ttctgaatta
    21721 atcgtgattc gattttttaa aaccgatttt cttttaaaac caagtattta tggtttaacc
    21781 accgatatga ttaggttcga tgttaatggt agtgatcatg caaatccacc aaataatgaa
    21841 agaataccta cgccacatat acacatatat actgaagaat ataataatgg tgttattgcg
    21901 atcccattaa aagatattga agatttagaa ttaacagatg aaattataga atcattagac
    21961 ttctttatga agtatactaa tataaaacac gataatatta taatagaatc aaaattactg
    22021 taaaagaaat ggagggatac ttagtgaaga ctatcgaaga aagaatgaac gaatatttca
    22081 actggttaaa acaaaattat atcttcaaag aattagatag ttctacagaa attactactc
    22141 ccttaaagaa ccatttgaat gattttatta gaatatatgc tgatacacta cctaataatg
    22201 aaatttgtct atcagatgac ggattgacga ttaatgaatt agaaatgttg ggtattgata
    22261 taaacacaaa aacgagaact aaacttatac agaatatttt aaatcaattt aatttaaaat
    22321 tagttgataa agaaattaca gcggatgtta aaaatgagag ttttgctcag tctaaacata
    22381 atttaattca aggcatattg aaaatttatg accttacttt aactactaaa tctaacgtta
    22441 caaacatatt ctatgaagaa gtatttgaat tcttatatga ccaaaaaata agaggtttag
    22501 cacaagtttc tgtttctgga gaatcaggtt taaaatattc tattgattat attgtttctg
    22561 aaacaaaatc acaaccagaa aaactagtta actttacaaa caacttagat ttcaacaaaa
    22621 taactaatga agcttatatt taccgtgata tcaaaccaaa cagaccatcc agaaacaaat
    22681 tagaacctat catgttgata attgtaaatg atgtagatca tccgataaat gaaagagcac
    22741 aaactgtagc agaacatgaa aaccttgaga tattaaaatg gtctaataaa tcaaaaatca
    22801 ttgaaacttt aacctcataa attagcagta gtcccttatt tatattcttt aatttccaaa
    22861 ccatatcgtg caaatagaaa agcagataac ttttttattt gcacgtttta ttttagaaca
    22921 agaaagaaca aggtcaatga gtcagaaaaa ctttttcttg atacgtattt gacacttgct
    22981 cttttaagaa tactaacatt tcattgtatt tctgttaaat taacggagaa tgaatgatat
    23041 ctttatacta ataatcttaa ctttttaaca tataaaatta atacattgta ctaaagtttc
    23101 aattatttta taattatata aatgaatcgt atacacttag ttagacaaat ctaagaattt
    23161 agatattgtt taattataaa actatcgatt cacatataaa taaaaggaga taacagtatg
    23221 aggagattat tcagtctatt actagctagt acaatgattt tagtcgcatg tgggaatgct
    23281 agcaatgaaa ataaggaatt tgaagacgaa aaaaaatcag aagtaaaaaa agaagctaag
    23341 aaaaataata ataaaccaaa gaacgtaaag aagaatcaag atataaacaa aaacaataat
    23401 gagcaagttc aaaatgcaaa taataatcaa ccagtcttaa ataataatag taatcataac
    23461 aatcaacaac aaagcaataa aaacaattac acagttatag aaaacgggaa tacatttaca
    23521 gaaatttata atggacaagc atttacaact acaaataacc ctattagaga aggatatgta
    23581 gagggagaaa cagacccgat atataaaaga gagtataagc atttttatac acctgaagaa
    23641 gctcaaagag cacaagaaaa tagcgaccaa attttaagag aaatgggtct cgaaccagaa
    23701 aggtatgaat aaagtcaaac taaataattt cgggtagccc gcctaccctt attatttttt
    23761 ttgccgattt tgaggaggag aaataagatg acatcattta ctattaaaaa aagaaagtcg
    23821 ggattcaaaa ctaaagcaga ggcaagtaat gctgcacaac aattgattag agatttaaag
    23881 gatggtaata aaattgaaga taacaaaaag tttacagcat actacagtga ctagataaat
    23941 ttaaagaata aaatgtaaat gtcaatataa aaatgtacat aaatgattgt ataagaatgt
    24001 acaaaattgt ttgctaagta atttccttct taggtgaatg atcttttaat ctatacgatt
    24061 tgcctttgat tttaactaca cttgaatgat gcaatatcct atccaaaatc gcatttgcga
    24121 tttttggatc atcaaatatt tcattccata agttgaaatt gatatttgtg gtaaatattg
    24181 tacttttctt ctcatatctt aaatctatta attgaaagaa tagtttggca t
//
