LOCUS       NZ_CP102415            23696 bp    DNA     circular CON 26-AUG-2024
DEFINITION  Amycolatopsis roodepoortensis strain ZEL-1 chromosome, complete
            genome.
ACCESSION   NZ_CP102415
VERSION     NZ_CP102415.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis roodepoortensis
  ORGANISM  Amycolatopsis roodepoortensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Biodegradation of petroleum hydrocarbons by Amycolatopsis orientalis
            ZEL-1, genome analysis and its potential in plant protection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2022) College of Life Sciences, Sichuan Normal
            University, No. 1819, Section 2, Chenglong Avenue, Longquan
            District, Chengdu 610101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024628825.1-RS_2024_08_26
            Annotation Date                   :: 08/26/2024 06:13:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,064
            CDSs (total)                      :: 8,994
            Genes (coding)                    :: 8,928
            CDSs (with protein)               :: 8,928
            Genes (RNA)                       :: 70
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 27 of 66
            Pseudo Genes (incomplete)         :: 44 of 66
            Pseudo Genes (internal stop)      :: 4 of 66
            Pseudo Genes (multiple problems)  :: 9 of 66
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:48:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7713009
            Orig. end                         :: 7736705
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102415.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23696
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="27"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23696
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23696
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13696]"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13696
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(531..545)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            724..1596
                     /gene="rpsB"
                     /locus_tag="NQK81_RS37160"
                     /old_locus_tag="NQK81_37160"
     CDS             724..1596
                     /GO_component="GO:0015935 - small ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032886.1"
                     /locus_tag="NQK81_RS37160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37160"
                     /product="30S ribosomal protein S2"
                     /protein_id="WP_034310929.1"
                     /transl_table=11
                     /translation="MAVVTMKQLLDSGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQQ
                     TLTYIDRAYEFIKETVAHGGTIMFVGTKKQAQEAIAAEASRVGMPYVNQRWLGGMLTNF
                     QTVHKRLLRLKELESQEQTGGFAGLTKREILTLTREKDKLEKTLGGIRDMAKVPSIVWI
                     VDTKKEHIAVGEARKLNIPVVAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVVAEAAA
                     AGLMARSSRNGSSADAKPEAGVATDEPLAEWEKELLAGSETAAADAKEAAAATEAATEA
                     PAEQATASS"
     gene            1689..2513
                     /gene="tsf"
                     /locus_tag="NQK81_RS37165"
                     /old_locus_tag="NQK81_37165"
     CDS             1689..2513
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="tsf"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074497.1"
                     /locus_tag="NQK81_RS37165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37165"
                     /product="translation elongation factor Ts"
                     /protein_id="WP_126733406.1"
                     /transl_table=11
                     /translation="MANYTAADVKRLRELTGSGMMNCKKALEENDGDFDKAVEFLRIKG
                     AKDVGKRAERATAEGLVAGDGGVLIELDSETDFVAKNEDFQALAAKIVEVAKAEKTSDV
                     EKLKAASLDGKTVEEQVQELAARIGEKLELRRVAAYEGTTTTYLHRRGADLPPAVGVLI
                     EYTGEGEAAAEAARGAAMQVAALKAKYLTREEVPAEVVENERRVAEATAREEGKPEQAM
                     PKIIEGKVNAYYKDNVLLEQPSVKDNKKTVKALLDEAGVSVSRFARFEVGQA"
     gene            2606..3349
                     /gene="pyrH"
                     /locus_tag="NQK81_RS37170"
                     /old_locus_tag="NQK81_37170"
     CDS             2606..3349
                     /EC_number="2.7.4.22"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0033862 - UMP kinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223864.1"
                     /locus_tag="NQK81_RS37170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37170"
                     /product="UMP kinase"
                     /protein_id="WP_005154669.1"
                     /transl_table=11
                     /translation="MGVRVEGGYRRVLLKLGGEMFGGGSIGVDPDVVHSVAQQIADVAR
                     TGVQIAVVIGGGNYFRGAELSQRGMDRDRADYMAMLGTVMNCLALQDFLEKEGLPTRVQ
                     TAITMGQVAEPYIPRRAERHLEKGRVVIFGAGVGMPYFSTDTAAAQRALELGCEAVLMA
                     KAVDGVYTADPKSDPTAEMFHEISHREVLERDLKVADATAFSLCMDNNMPIIVFNLLTE
                     GNIARAVSGERIGTLVDTPADGVPA"
     gene            3401..3958
                     /gene="frr"
                     /locus_tag="NQK81_RS37175"
                     /old_locus_tag="NQK81_37175"
     CDS             3401..3958
                     /GO_function="GO:0008135 - translation factor activity, RNA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="frr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943637.1"
                     /locus_tag="NQK81_RS37175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37175"
                     /product="ribosome recycling factor"
                     /protein_id="WP_034310934.1"
                     /transl_table=11
                     /translation="MIDETLLDAEEKMEKAVSVAKEDLSSVRTGRAHPGMFSRIVVEYY
                     GAPTPLNQMASVNIPEARMALIKPYDQTSLNAIEKAIRESDLGVNPSNDGNVIRIVIPQ
                     LTEERRKEMVKVAKAKGEDARVSIRSVRRKAKEELDRIKKDGEAGEDEVVHAEKELQNL
                     TDTYSHKVDELVKHKEAELLEV"
     gene            3958..4854
                     /locus_tag="NQK81_RS37180"
                     /old_locus_tag="NQK81_37180"
     CDS             3958..4854
                     /EC_number="2.7.7.41"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336218.1"
                     /locus_tag="NQK81_RS37180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37180"
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="WP_126733405.1"
                     /transl_table=11
                     /translation="MSQVSEEREDRVDAPEPVPAEKPEPAKKVSRAGRNLPAAIGVGLL
                     LGAAIVTSLLTVRYLFIGIIAIAIAVGTIELAGALKRAAGIRIALVPVLVGGQAMIWLA
                     WPYGREGALTAFVLTVLVCLLWRLPGGADGYLRDISASVFAAAYIPLFGAFAAMLVPPA
                     DGVGRVLAFMIGVVASDTGGYIAGVLGGKHPMAPSISPKKTWEGFAGSLVAGVVAGALT
                     LSLLLDGHAWQGVLFGAAIVCTATLGDLVESLIKRDLGVKDMGNMLPGHGGLMDRLDSL
                     LPSAVVSWLLLSAFVPL"
     misc_feature    complement(4918..4929)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.51"
                     /tool="antismash"
     gene            5034..5670
                     /locus_tag="NQK81_RS37185"
                     /old_locus_tag="NQK81_37185"
                     /pseudo=""
     CDS             5034..5670
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012363.5"
                     /locus_tag="NQK81_RS37185"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37185"
                     /product="carboxylesterase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTGEYRSFQGIPFAAPPVGDLRWAPRKDLDPGPRCGTRADRGPG
                     CVQAAGSARGRVTTRIACTST"
     misc_feature    5577..5579
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5667..5882
                     /locus_tag="NQK81_RS37190"
                     /old_locus_tag="NQK81_37190"
     CDS             5667..5882
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012363.5"
                     /locus_tag="NQK81_RS37190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37190"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_257485204.1"
                     /transl_table=11
                     /translation="MTALPANLTSAQQELAALMIRYWTVFARTGDPNGGEPPKWRPSPR
                     TQSPAPGAIGPVDLAAVHNCRFWAGI"
     gene            complement(5896..6741)
                     /locus_tag="NQK81_RS37195"
                     /old_locus_tag="NQK81_37195"
     CDS             complement(5896..6741)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630575.1"
                     /locus_tag="NQK81_RS37195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37195"
                     /product="VOC family protein"
                     /protein_id="WP_257485205.1"
                     /transl_table=11
                     /translation="MSLGSAAHTSVIPSGIPCWIELACRDESAAQTFYSGLFDWEYVVQ
                     RDPATPTGRYSIATLNGVPAGGLYRAATGGPAGWSVHISVPQAAAAAEWVDSLGGRVTL
                     GPVAIPHRGNIVHAVDACGAHVVFWEPPATWEFATGVPNTFSGADLNTHDGAAADHFYC
                     RLFNYTSHQIGDGASLDYAEWLIEHEPVLYRYVMGSEYRPDTPPHWMVYFELDPARGAD
                     AAAGQALMLGGTVVVQPYDTPYGRMAILADPDGSVFAVIDHSRAVEGWGTAEVDDPYDD
                     "
     gene            6857..7696
                     /locus_tag="NQK81_RS37200"
                     /old_locus_tag="NQK81_37200"
     CDS             6857..7696
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336215.1"
                     /locus_tag="NQK81_RS37200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37200"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_257485206.1"
                     /sec_met_domain="PCMT (E-value: 7.6e-05, bitscore: 21.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRWFPRALSSFRRGGEEVLPSPNIWYYQKAYEVENRAQDVDDEIW
                     RVLAGYRDWSGADVLDIGCGDGFHLPRFAATARSVVGVEPHEPLVLDARKRVERLENVE
                     VRQGRAQRLPLPDAAFDVVHARTAYFFGPGCEPGLREAERVLRPGGLLVIVDLDVTSEP
                     YGRWMRLDLPHYDPPGVEKFFARQGFGCRKVMTRWQFEDAAAMEAVLKIEFSAPVAAKA
                     IADVRRLNEVSSGAGEKRMTLPVGYRVHTRVKPTGLVVPGHSASSSGVASSASPRMP"
     misc_feature    7199..7201
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7642..8247)
                     /locus_tag="NQK81_RS37205"
                     /old_locus_tag="NQK81_37205"
     CDS             complement(7642..8247)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223869.1"
                     /locus_tag="NQK81_RS37205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37205"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_257485207.1"
                     /transl_table=11
                     /translation="MRRPFPPEHGRPAFGPWSRGGFGDFPPGPGGPGHRHRHGRRGGPG
                     RRGKRGDVRAAILALLSEQPRHGYEIIREIGERSGGFWKPSPGSVYPTLQLLADEGLVI
                     SKDENGKKLFELTESGRAAAEQQDAVPPWEQIAHDVDPAEVNLRKAGATLAAAVAQVMH
                     AGSESQQARTVDVLNEARRTIYGILGEAEDATPDEDAE"
     gene            complement(8336..8803)
                     /locus_tag="NQK81_RS37210"
                     /old_locus_tag="NQK81_37210"
     CDS             complement(8336..8803)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004559290.1"
                     /locus_tag="NQK81_RS37210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37210"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_126733401.1"
                     /transl_table=11
                     /translation="MRSELDDVYRRVYREPPYLEGEDDVARFGVLFAEHAALPGFAMTT
                     VREAGALGGFAYGVRQEIGWWPERATAPAPSWLDGEALFYVYELALLPELRGRGLGRAL
                     LDDLLKERPERFAVLASRVEAPARRLYRRWGWRKVGEFDFGGIDLLALDLS"
     gene            complement(8793..10001)
                     /locus_tag="NQK81_RS37215"
                     /old_locus_tag="NQK81_37215"
     CDS             complement(8793..10001)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226215.1"
                     /locus_tag="NQK81_RS37215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37215"
                     /product="MFS transporter"
                     /protein_id="WP_257485208.1"
                     /transl_table=11
                     /translation="MAAADLLGLPSTRGRFPLIAAQSVDALGTGLFLPFAVVYFHAAKG
                     LSLTAVGAALSIAAMIALPSGPLAGRLIDRFGPGRMVITANLIRAVTFTGYVFAGEAWH
                     LVVLAAITFWGEGMFWPSTGALVAQVADEGQRARWYAMERALRNVGIGLGGLLGAAMVA
                     WGGPGGYTTIVLVNAASFVVAAVLVASWRAPAGTPRESGSEAVPPGGYRKVLADRIFRG
                     VLVTVFVFALCDLALTVLLSAYVLDGLKLPAWQPGVLFAINTVLVVLAQTVVSRRVERR
                     RMPRTLQVSAAVWAVSFVLFALVPTGRPTTAFLVLTLAMIVFTAAELLQAPTSSALTVA
                     IAPARLRGRYLGLEELVWSVARVIAPATFTWLLSHGAALPWLVLIGCCGVAIVVLGRLN
                     RAL"
     gene            complement(10001..12169)
                     /locus_tag="NQK81_RS37220"
                     /old_locus_tag="NQK81_37220"
     CDS             complement(10001..12169)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226216.1"
                     /locus_tag="NQK81_RS37220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37220"
                     /product="YcaO-like family protein"
                     /protein_id="WP_257485209.1"
                     /sec_met_domain="YcaO (E-value: 8.1e-61, bitscore: 205.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 6.2e-79, bitscore:
                     264.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSEEVRPRLDGIEITDLEPELCFLVTPNGGQFYIAAPTREFRAW
                     ASRCDGTSTRAELLAGMDPDYEEMMEILEADGCLSSGRDTGDDDVAATSILLTGSPALT
                     EPLAEILHSGGYASVETVPYFHDLSEVDTENTVVVAAFDHPAYTELIALDALCAGSGVR
                     WLPLRRERGRVIAGPAIAPGGIDFADVVARRRSAAQDPRVVEAFLSAPSDSIPLRPGDA
                     RWALTTLAVHLEHWLSGGRSGLTTGEIELNPADLTEIRRPILPVPDRARPVPATTDPGL
                     LVDDQTGIVTGVGEIPPAPGMPARLRVCAVDVADMRRVTNWPNDRQAFGTSWHDFDLAR
                     QSAIGEAVERYCGSWLAPEREVCFGSYKQFFRYGVPALDPQRLNLYSATQYRSPGFPFA
                     PLTQDTECSWVEGFSHTTGEPVWVPAFLFSNERRPEEAYFADPLIAGLASGTTEEHAVT
                     SGLEEVLERDTTMLWWANTPRLGRLSIPDEIRSLIADATDDYEVTLIHLDNEFDVPVVA
                     AVVLDRVKRWLSIGFATRPDALEAAKKALAEGFTLQHTCRALDDERELAGMRRDLPHLG
                     NLKPHRADRRYLDSYREDFADVADLLCQQQIYLDPRAVKRVAPWLRDLPSRGWDDLPAL
                     GERRLKAYQARVEARGFEVISVDLTTCDVAAAGFHAAHTLVPGLVSNFPAGSPLWGNGR
                     IADAAVALGWRDEPLAEHELNVFPLPHA"
     gene            complement(12258..12392)
                     /locus_tag="NQK81_RS37225"
                     /old_locus_tag="NQK81_37225"
     CDS             complement(12258..12392)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004561011.1"
                     /locus_tag="NQK81_RS37225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37225"
                     /product="hypothetical protein"
                     /protein_id="WP_257485210.1"
                     /transl_table=11
                     /translation="MISTFERPAAVVVHNRAVVHNRAVVHNRAVVHNRAVVHNRSAAK"
     misc_feature    12420..12433
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.19"
                     /tool="antismash"
     gene            12590..13696
                     /gene="rlmN"
                     /locus_tag="NQK81_RS37230"
                     /old_locus_tag="NQK81_37230"
     CDS             12590..13696
                     /EC_number="2.1.1.192"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0016433 - rRNA (adenine) methyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0030488 - tRNA methylation [Evidence IEA]"
                     /GO_process="GO:0070475 - rRNA base methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rlmN"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336213.1"
                     /locus_tag="NQK81_RS37230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37230"
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="WP_126733398.1"
                     /sec_met_domain="PF04055 (E-value: 1.9e-22, bitscore: 79.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALPLVFDAPKRGLPPRHLADLSAAERAAAVAELGEKPFRAKQL
                     SNHYFSRLTVDPAEMTDIPAASREKLVGDLMPTLLTEIKALACDDGTTRKTLWRAHDGT
                     LLESVLMRYPDRATLCISSQAGCGMACPFCATGQGGLDRNLSTAEIVDQVRAAAAVMRD
                     GAMPGGPGRLSNIVFMGMGEPLANYKRVVAAVRRITDPSPDGLGIGQRSVTVSTVGLAP
                     AIRKLADEKMQVRLAVSLHTPDDELRDTLVPVNERWSVDEVLSAARYYADTSGRRVSIE
                     YALIRDVNDQPWRAELLAKRLRQHLGQLVHVNVIPLNPTPGSKWDASPKPVEREFVRLV
                     NAGGVACTVRDTRGQEIAAACGQLAAEN"
     gene            13730..14008
                     /locus_tag="NQK81_RS37235"
                     /old_locus_tag="NQK81_37235"
     CDS             13730..14008
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032876.1"
                     /locus_tag="NQK81_RS37235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37235"
                     /product="hypothetical protein"
                     /protein_id="WP_257485211.1"
                     /transl_table=11
                     /translation="MYAPSLLDPAAEELKLTDVIGHGATGVAREARTLLGERFSSVTFM
                     YVLMRAFEVEYMAARDASRWHEFHGGPYALSDADLEAVLAPWLGSRR"
     gene            14033..14443
                     /locus_tag="NQK81_RS37240"
                     /old_locus_tag="NQK81_37240"
     CDS             14033..14443
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032875.1"
                     /locus_tag="NQK81_RS37240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37240"
                     /product="hypothetical protein"
                     /protein_id="WP_257485212.1"
                     /transl_table=11
                     /translation="MYCLQAVVVTESARAELPASVEGARLVPVGHHLSLMPLPETLPEA
                     GEFRTVLAACSEHGAVAYIEAEYFGGVGTQSAQVWDRGETVLGPLHLAEDEPALAAGSP
                     ISQALRRLGVAKGDHFDEFDAVGLGRHRHTGD"
     misc_feature    complement(14478..14492)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.07"
                     /tool="antismash"
     gene            14558..15373
                     /locus_tag="NQK81_RS37245"
                     /old_locus_tag="NQK81_37245"
     CDS             14558..15373
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336209.1"
                     /locus_tag="NQK81_RS37245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37245"
                     /product="DUF1206 domain-containing protein"
                     /protein_id="WP_257485213.1"
                     /transl_table=11
                     /translation="MSATKARQVRHNTAVQVLGRIGMGCYGLVYLLIGYLAVRVAVGGG
                     GQEADGRGAITEVGSTPMGGVLLWVLAAGLVAYGLWQGLLAAVGYTWIDKQRKRTVKRV
                     TSGVRCVVGISLGVYAARVAMGSGEQGSGDQKQQEFTARLLGLPAGPFLVTLVAVVVFG
                     VAVGSVVKGVRRTFLQDLDLSRLPSGTRRWVERLGRIGYVARGVVFGVVAVLVGYAALT
                     HDAARSGGLDAALRTLAAQPFGTVLLIVVAAGVAAFGVYCVGAARAQRG"
     gene            complement(15419..15742)
                     /locus_tag="NQK81_RS37250"
                     /old_locus_tag="NQK81_37250"
     CDS             complement(15419..15742)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005154651.1"
                     /locus_tag="NQK81_RS37250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37250"
                     /product="putative quinol monooxygenase"
                     /protein_id="WP_257485214.1"
                     /transl_table=11
                     /translation="MIFITAKFRVRPEHADRWPEIAREFTEATRAEPGCLWYDWARSLD
                     DPDEYVLVEAFRDDEAGAAHVGSEHFRTAQRELPRYLAETPRIVNAKVDQDDWSELGEL
                     AVE"
     gene            complement(15739..16515)
                     /locus_tag="NQK81_RS37255"
                     /old_locus_tag="NQK81_37255"
     CDS             complement(15739..16515)
                     /GO_function="GO:0019152 - acetoin dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_process="GO:0045150 - acetoin catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-124). E-value: 3e-10. Score:
                     32.2. Matches aSDomain:
                     nrpspksdomains_NQK81_RS37255_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787497.1"
                     /locus_tag="NQK81_RS37255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37255"
                     /product="acetoin reductase"
                     /protein_id="WP_257485215.1"
                     /sec_met_domain="adh_short (E-value: 6e-32, bitscore:
                     110.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKNVLVTGAARGIGKGIALRLAADGHDVAVNDVAAHEAELEAVA
                     KEIRETGRRSAAITADVADSESVTAMVAETAGALGSLDVMVANAGIAQVLPLLEVTPED
                     WDRMMAVNARGIFLCYQAAAKQMIRQGNGGKIIGAASIVAHRPFALLGHYSASKWAVRG
                     LTQAAAMEWARHGITVNAYCPGIVGTAMWDLIDEKLAESEGIRKGQAIEKYSNLIHLGR
                     VSVPEDVAAYVSYLASPDSDYMTGQSVMIDGGIQFS"
     aSDomain        complement(16144..16503)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NQK81_RS37255_PKS_KR.1"
                     /evalue="3.00E-10"
                     /label="NQK81_RS37255_PKS_KR.1"
                     /locus_tag="NQK81_RS37255"
                     /protein_end="124"
                     /protein_start="4"
                     /score="32.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VLVTGAARGIGKGIALRLAADGHDVAVNDVAAHEAELEAVAKEIR
                     ETGRRSAAITADVADSESVTAMVAETAGALGSLDVMVANAGIAQVLPLLEVTPEDWDRM
                     MAVNARGIFLCYQAAA"
     CDS_motif       complement(16441..16500)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NQK81_RS37255_0001"
                     /evalue="7.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="NQK81_RS37255"
                     /protein_end="25"
                     /protein_start="5"
                     /score="9.1"
                     /tool="antismash"
                     /translation="LVTGAARGIGKGIALRLAAD"
     misc_feature    16589..16603
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.98"
                     /tool="antismash"
     gene            complement(16611..17384)
                     /locus_tag="NQK81_RS37260"
                     /old_locus_tag="NQK81_37260"
     CDS             complement(16611..17384)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630557.1"
                     /locus_tag="NQK81_RS37260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37260"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257485216.1"
                     /transl_table=11
                     /translation="MRDIPIDEVDHLDRAVVAIRTDYPPGHRILPHRHRRAQFLYSATG
                     SMRVETADGTWTIPTRRAVLVPPETVHQVFTTTVSTRSLYIEPKAVPWFPRRCQVVEVS
                     ALLRELLNEAVGVPELYTPRGRDAAVIGLALHEIRRAAPVRLDLPLPKHDRLRALCESF
                     LDDPDIHDPAGGWAARLHVSERTLNRLFTTETGMGFARWRQRACVLHSLSLLSDGLPIA
                     GIAASLGYESPAAFSTMFARLLGTSPKDYRAASSL"
     gene            17476..18279
                     /locus_tag="NQK81_RS37265"
                     /old_locus_tag="NQK81_37265"
     CDS             17476..18279
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032872.1"
                     /locus_tag="NQK81_RS37265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37265"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_257485217.1"
                     /transl_table=11
                     /translation="MLIEIAVLLGFGCLSGVTTVLFGFGGGFVTVPVVYAFALADPENA
                     SSAMHVAVATSTAVMVVNAGSATAAQLRTGRLRRDYLWPLIAFIGLGAVLGSFAATMAD
                     EGVLRWLFVAYLALTIADSVARKGFVSRRDDGRPRALGGFTISAGGIGIGAVASFLGVG
                     GSVLTVPLMRRKGLPMADAAALANPLSLPVAVIGTAVYAFAATGPAPGAAHLGYIDLVA
                     AGALLCGSLPAIAVIRRVVGRIPDRAHAIAYLALLATALIAVVVR"
     gene            18407..20392
                     /locus_tag="NQK81_RS37270"
                     /old_locus_tag="NQK81_37270"
     CDS             18407..20392
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032871.1"
                     /locus_tag="NQK81_RS37270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37270"
                     /product="peptidase S8/S53 subtilisin kexin sedolisin"
                     /protein_id="WP_257485218.1"
                     /transl_table=11
                     /translation="MKLRSITKRMFVLGLLTALGTTGATSVATAEPQLPPAEVNATGQP
                     HGAWDPVGPNSVGGLLAVSPAGLAMMVPGPPALWLSGDRGASWTVRRGLPADTSIQGFF
                     ADPVNPDRMLAVGNSPGGMPGEWHGMFLRTTDRGQTWETLREWYPDGAFGMATDPTGRV
                     VVVQNLDSLSVSIDGGENWNDVPRTWPREGIASPVGALKLTMVGDDAYFTTVYPEYALW
                     VVRGVSGKEPKAELVYRTNGEVNQVAADGGRLVVTVGSELHGSTDGGKTWTVLRREPAG
                     QTLREPRFVGGRLYVSTYNDIDVSPDFGRTWIRKPVPAPGEGVSDMIELPAAPGKPATT
                     LISSLYRGVYADGGKSGYQQIGVPGETIRDLVTTGNLLRESVVAAGVQEIYNTPLPRGK
                     VSATDRVWQSHPTDRLHEDASLSVSPGRPDVVWQVTRNGFSLDVLRSGDGGRSWQFAAK
                     AKEGLPRTIFAHPADPDRIIVSAFAPSGYVLHRSDDAGKTWEKLSVDSGFTTFAGDPWN
                     PNRVWGGDSGGLSRSDDGGKTWTHVTSQPVSSISVSRWGGGRVLIGGAGIHLSEDGGRT
                     FRRVRDGEDPREISRILPHPFDFRVWFASDATGGGVLRSTDFGRTWSPVPGALPDPRVL
                     SLAISADGRYLFAGTAQSGAYRLKLY"
     misc_feature    complement(18408..18422)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.27"
                     /tool="antismash"
     misc_feature    complement(18427..18440)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.82"
                     /tool="antismash"
     misc_feature    18427..18440
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.27"
                     /tool="antismash"
     gene            20473..21654
                     /locus_tag="NQK81_RS37275"
                     /old_locus_tag="NQK81_37275"
     CDS             20473..21654
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (20-385). E-value: 1.9e-52.
                     Score: 170.3. Matches aSDomain:
                     nrpspksdomains_NQK81_RS37275_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032870.1"
                     /locus_tag="NQK81_RS37275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37275"
                     /product="cysteine desulfurase-like protein"
                     /protein_id="WP_257485219.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.1e-49, bitscore:
                     168.4, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3e-05, bitscore:
                     22.5, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.3e-06, bitscore:
                     26.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDVAALRLHFPSLADGTAFFDGPAGTQTPRPVADAIARTLTGP
                     LSNRGMVSPSELNAENAVAAFRAAYADFLGVPAEGVVHSRSATQLTYDFSRHLAKNWRA
                     GDEIVVSRLDHDANVRPWVQAADRAGMTVRWLDVDPETTELDLDTLVLTERTKLVAVTA
                     ASNVLGTKPPIRRIADLAHDAGALVFVDGVHYAAHDLVDVPALGADFFVCSPYKFLGPH
                     CGVLGASPSLLETVEPDKLMPSPDTVPERFEFGTLPYEILAGATAAVDFLAALDPGSAG
                     SRRARLANSMNSLHEHESLLLARLEKGLGDAVTVHGKAADRTPTVLMGLGGREREAQEY
                     LAERNVVAPAGSFYAYEVFAALKLEDPALRVGLAPYTSTEDVDRLLDGLSAFG"
     aSDomain        20533..21627
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NQK81_RS37275_Aminotran_5.1"
                     /evalue="1.90E-52"
                     /label="NQK81_RS37275_Aminotran_5.1"
                     /locus_tag="NQK81_RS37275"
                     /protein_end="385"
                     /protein_start="20"
                     /score="170.3"
                     /tool="antismash"
                     /translation="FFDGPAGTQTPRPVADAIARTLTGPLSNRGMVSPSELNAENAVAA
                     FRAAYADFLGVPAEGVVHSRSATQLTYDFSRHLAKNWRAGDEIVVSRLDHDANVRPWVQ
                     AADRAGMTVRWLDVDPETTELDLDTLVLTERTKLVAVTAASNVLGTKPPIRRIADLAHD
                     AGALVFVDGVHYAAHDLVDVPALGADFFVCSPYKFLGPHCGVLGASPSLLETVEPDKLM
                     PSPDTVPERFEFGTLPYEILAGATAAVDFLAALDPGSAGSRRARLANSMNSLHEHESLL
                     LARLEKGLGDAVTVHGKAADRTPTVLMGLGGREREAQEYLAERNVVAPAGSFYAYEVFA
                     ALKLEDPALRVGLAPYTSTEDVDRL"
     gene            21812..22363
                     /locus_tag="NQK81_RS37280"
                     /old_locus_tag="NQK81_37280"
     CDS             21812..22363
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS37280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_37280"
                     /product="hypothetical protein"
                     /protein_id="WP_257485220.1"
                     /transl_table=11
                     /translation="MIDNGRFAMRFRSVAASVLLGCALCVAPAALGAGARSLAIQPCPE
                     VNDPPDYTISNGAKAWMKTNLRSDYLRGPGTITYNKTTTSSVNASITGTTSAEAGVIFA
                     KASVSLAVSVGASYSKSDSWSYSATVPAGKTLRLQQYKEARSFTVQKYRIVPPCKVKYL
                     WKKNAVAPVKSPSYLWQLIG"
     gene            22501..23328
                     /locus_tag="NQK81_RS37285"
                     /old_locus_tag="NQK81_37285"
     CDS             22501..23328
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630552.1"
                     /locus_tag="NQK81_RS37285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_37285"
                     /product="acetylxylan esterase"
                     /protein_id="WP_257485221.1"
                     /transl_table=11
                     /translation="MGRLRARILIAGMVALATVGIAPAATAETGIASRWSEPGPYTVTV
                     EALDSTHTMYRPSRLEKHPVILWGNGTGAGPKIYDGLLRHLASHGFVVAAADTPNAGSG
                     QEMLAGATTLIAENSRPGSPYQGKIDTAHIGATGHSQGGGGAIVAGADARVTTTIPIEP
                     GPQGSAAALKGPSFFLGGQFDTIVVPGLLVIPRYRLADQVPAIYGELGGATHFTPVGDG
                     GGFRGAITAWFRFWLSGDERARAEFFGPSCGLCRDGAWSDVRRNAKALAVPGA"
ORIGIN
        1 ggcgaacatc accactccct cggcggccgc gaggacgttc gcgcccgggg gtgcggcgag
       61 gtcgacgccc cggtggccgg ggccgtacgg cgtcgagggc ggctcgaagt acctggtgac
      121 gctcggtgcc ggcgagagcg gccaggagag gcgcccctgc ggggtgggcg cccctctcgc
      181 cgtcccgggc atcgccgcgg acgtgaggat cgcgagcacg gtcgcgagga tcgccaggcg
      241 gggaaggcgc cgggcgtgcc ctgggcggcg gtgcctgccg ccggtgcggt cgatcgcgaa
      301 ggaatgcctg gtgacagggc gggatgaggt cgtcggtgtc atgtgttcca ggttgggggt
      361 acggcgtggc gggcagggcg cgccggtgga atctgtggat aaccgaggtg gttgtggaca
      421 acccctctca tcaggggctg ccggtgcggt acccggtggc gacagggagt agactctttt
      481 gcgcggtccg cggcagcgga ctgacttcgc gtgcacgtgc gcgctcccga tggccgatct
      541 cctcacggag ggtcaggaca gccgggggca cacggcccgg cggtccctgg ggtatttcgc
      601 tcccgggtcc gggcccgagc atcggcacca gggcgatcgg ccacccggcc gagagcgacg
      661 aaccgagcaa gcgcgttccg gcggagccgg gcgcgcacga cacagaagag gttgattccg
      721 gcaatggccg tcgtcaccat gaagcagctg ctcgacagcg gcgtgcactt cgggcaccag
      781 acccgtcggt ggaacccgaa gatgaagcgc tacatcttca ccgagcgcaa cggcatctac
      841 atcatcgacc tgcagcagac gctgacctac atcgaccgtg cgtacgagtt catcaaggaa
      901 accgtcgcgc acggcggcac catcatgttc gtcggcacga agaagcaggc ccaggaagcc
      961 atcgcggccg aagcctcgcg cgtgggcatg ccctacgtga accagcgctg gctcggcggc
     1021 atgctgacca acttccagac ggtgcacaag cgtcttctcc gcctgaagga gctcgagtcg
     1081 caggagcaga ccggcggctt cgccggcctg accaagcgcg aaatcctcac gctcacccgt
     1141 gagaaggaca agctcgagaa gaccctcggc ggtatccgcg acatggccaa ggtgccgagc
     1201 atcgtgtgga tcgtcgacac gaagaaggag cacatcgccg tcggcgaggc tcgcaagctg
     1261 aacatcccgg tcgtcgcgat cctggacacc aactgcgacc cggacgaggt cgactacccg
     1321 atcccgggta acgacgacgc catccgttcg gccgcgctgc tgaccaaggt cgtggccgag
     1381 gccgccgccg ccggtctgat ggcccgctcc agccgcaacg gttcctccgc cgacgccaag
     1441 cccgaggcgg gcgtcgccac ggacgagccg ctggccgagt gggagaagga gctgctcgcc
     1501 ggctccgaga ccgccgccgc ggacgccaag gaagccgccg ccgcgaccga ggccgccacc
     1561 gaggctccgg ccgagcaggc caccgcctcc tcctgatcca cctgcccgtg gggccgcctg
     1621 gaggcggccc cacgggtgac ttccccaaaa gactttctcg tacctgaaaa aggacggaca
     1681 cacccacgat ggcgaactac accgccgcag acgtgaagcg tctccgggag ctcaccggct
     1741 ccggcatgat gaactgcaag aaggcgctgg aggagaacga cggcgacttc gacaaggccg
     1801 tcgagttcct gcgcatcaag ggcgccaagg acgtcggcaa gcgcgccgag cgcgccaccg
     1861 ccgagggcct cgtcgccggt gacggcggcg tcctgatcga gctcgactcc gagaccgact
     1921 tcgtcgcgaa gaacgaggac ttccaggctc tcgccgcgaa gatcgtcgag gtcgcgaagg
     1981 ccgagaagac cagcgacgtc gagaagctga aggccgcctc gctcgacggc aagaccgtcg
     2041 aagagcaggt ccaggagctg gccgcccgca tcggtgagaa gctcgagctt cgccgtgtcg
     2101 ccgcttacga gggcaccacc accacgtacc tgcaccgtcg cggtgcggac ctcccgcccg
     2161 ccgtcggcgt gctcatcgag tacaccggtg agggcgaggc cgccgccgag gccgcccgtg
     2221 gcgccgccat gcaggtcgcc gcgctcaagg ccaagtacct gacccgcgaa gaggtcccgg
     2281 ccgaggtcgt cgagaacgag cgtcgcgtcg ccgaggccac cgcccgcgaa gagggcaagc
     2341 cggagcaggc catgcccaag atcatcgagg gcaaggtcaa cgcgtactac aaggacaacg
     2401 tcctgctcga gcagccgtcg gtcaaggaca acaagaagac cgtcaaggcc ctgctcgacg
     2461 aggccggcgt gtccgtgagc cggttcgccc ggttcgaggt cggccaggcc tgatccaggc
     2521 gcggaacaca agaatcacca ctgtgccccg tctccgtcca tcggggacgg ggcacagtcg
     2581 ggttcggagc attagggagg gcgacatggg tgtccgggtc gaaggcggat accggcgggt
     2641 gctgctgaag ctgggcggcg agatgttcgg cggcggttcc atcggggttg atccggatgt
     2701 ggtgcactcg gtcgctcagc agatcgccga cgtcgcgcgc acgggcgtgc agatcgccgt
     2761 cgtgatcggc ggcggcaact acttccgtgg cgcggagctg tcgcagcgcg gcatggaccg
     2821 cgaccgcgcg gactacatgg cgatgctcgg caccgtcatg aactgcctgg cgttgcagga
     2881 cttcctggag aaggagggcc tgccgacccg cgtgcagacc gccatcacca tggggcaggt
     2941 cgccgagccg tacatcccgc gccgcgccga gcgtcacctg gagaagggcc gcgtcgtcat
     3001 cttcggcgcc ggggtcggca tgccgtactt ctcgaccgac accgccgccg cgcagcgcgc
     3061 gctcgagctc ggctgcgaag ccgtcttgat ggcgaaggcc gtcgacggcg tctacaccgc
     3121 ggacccgaag agcgacccga ccgccgagat gttccacgag atcagtcacc gcgaggtgct
     3181 ggagcgggac ctcaaggtcg ccgacgccac cgcgttcagc ctgtgcatgg acaacaacat
     3241 gccgatcatc gtgttcaatc tgctcaccga ggggaacatc gcccgcgcgg tcagtggtga
     3301 gaggatcggc accctggtcg acacccccgc cgacggggtg cccgcgtagg cctgctctga
     3361 tcttcgcaat cggtacgcat acacaactac gggagttgcc gtgatcgacg agaccctcct
     3421 cgacgccgag gagaagatgg aaaaagcggt gtccgtcgcc aaggaggacc tgtcgtcggt
     3481 acgcaccggc cgggcccacc cggggatgtt ctcgcgcatt gttgtcgagt actacggcgc
     3541 gccgaccccg ctgaaccaga tggcgagcgt caacatcccc gaagcccgga tggcgttgat
     3601 caagccttac gaccagacct cgctcaacgc catcgagaag gcgatccgcg agtcggacct
     3661 cggcgtcaac ccgagcaacg acggcaacgt gatccgcatc gtcatcccgc agctcaccga
     3721 agagcgccgc aaggagatgg tgaaggtcgc caaggccaag ggtgaggacg cccgcgtttc
     3781 gatccgcagc gtccgccgca aggccaagga agagctcgac cggatcaaga aggacggcga
     3841 ggcgggcgag gacgaggtcg tccacgccga gaaggaactc cagaacctca ccgatactta
     3901 cagccacaag gtcgacgagc tggtgaaaca caaggaagcc gagctactcg aggtctgatg
     3961 agccaggtga gcgaggaacg cgaggaccgg gtggacgccc cggaaccggt tccggccgag
     4021 aagccggaac cggcgaagaa ggtttcccgt gccggccgca acctgcccgc cgcgatcggg
     4081 gtcgggctgc tgctgggggc ggcgatcgtc acgtccctgc tcaccgtgcg ctatctgttc
     4141 atcggcatca tcgcgatcgc catcgcggtc ggcacgatcg agctggccgg cgcactgaag
     4201 cgcgcggcgg gcatccggat cgcgctggtc ccggtgctcg tcggcggtca ggcgatgatc
     4261 tggctggcgt ggccgtacgg ccgcgagggc gcgctgacgg cgttcgtgct gacggtgctc
     4321 gtctgcctgc tgtggcggtt gcccggcggc gcggacggct acctgcgcga catcagcgcg
     4381 tcggttttcg ccgccgcgta catcccgctt ttcggcgcct tcgccgccat gctcgtccca
     4441 ccggcggacg gtgtcggcag ggtgctggcg ttcatgatcg gtgtggtcgc ttcggacacc
     4501 ggcggctaca tcgccggtgt actgggcggc aagcatccga tggcgcccag catcagcccg
     4561 aagaagacct gggaagggtt cgccggttcg ctcgtggccg gagtggtcgc cggcgcgctg
     4621 accctgagcc ttctcctcga cggtcacgct tggcagggcg tgctgttcgg cgcggcgatc
     4681 gtctgcacgg cgacgctggg cgatctcgtc gagtcgctga tcaagcgtga cctcggcgtc
     4741 aaggacatgg ggaacatgct gccggggcac ggcgggctga tggaccggct cgattcgttg
     4801 ctcccttcgg ccgtcgtctc ctggctgctg ctctccgcat tcgtgcctct ttaggtcaag
     4861 tccctgtgac gagccgggcg ctctgttatg gccgggggta tgcgcctcga cggatgggta
     4921 agcgatttct ggccacggct ctgagcttgg tgacgctcgg agcgctgacg acgaccgcgg
     4981 cggaggcggg ctgaggcccg gtcgtcggca cggattccgg tcccgtccgc ggcgtgagta
     5041 ccggcgaata ccggagtttc caaggtattc cgttcgccgc gcccccggtc ggtgatctgc
     5101 gctgggcgcc gcgcaaagac ctggaccctg gaccgcggtg cgggacgcga gcagaccggg
     5161 gccccgggtg cgtgcaggcg gcgggctcgg cccggggccg agtgacaacg aggattgcct
     5221 gtacctcaac gtgatcagcc cggccaagcc ggcgcggaag ccgcgtccgg tcatggcctg
     5281 ggtccacggc ggcagcttca cgtacgggcc ggaagcgact acgacttcaa gcgcatggcc
     5341 ctcggcgggg acgtggtcgt ggtgaccgtg aactaccggc tcggcgtgtt cggcttcttc
     5401 gggcttcagg accagaaggc cgcgcttcgc tgggggcagc gcaacgcgca cgtcttcggg
     5461 ggagatccgg ggaacgtcac gctgttcggc gaatcggccg gctcgatgag cgcgtgcgcc
     5521 cagctggctt ccccgtcggc ggcggggctg ttccagcgcg tgatcatcca gagcagttac
     5581 gagttcgcgg atcgcaacgg accttcgctt ctcccggaat gtccatgggt gcctcatatg
     5641 gagccgaatt ggcctatttg tccgatgtga ccgcacttcc ggcgaatttg acgtccgccc
     5701 agcaggaact ggcggcgcta atgatccggt attggaccgt cttcgcgcgc accggtgatc
     5761 cgaacggcgg ggaaccgccg aaatggcgtc cctcgccgcg gacgcaatcg ccggcgccgg
     5821 gcgcgatcgg cccggtcgac ctcgcggcgg tgcacaattg ccggttctgg gccggtattt
     5881 gaccggggag cgggctcagt cgtcgtaggg atcgtcgact tcggcggtgc cccagccctc
     5941 gacggcccgc gagtggtcga tcacggcgaa caccgaaccg tcggggtcgg cgaggatcgc
     6001 catccggccg tacggggtgt cgtagggctg gaccacgacg gtaccgccga gcatcaaggc
     6061 ctgtcccgcg gcggcgtccg cgccgcgggc cgggtcgagc tcgaagtaga ccatccaatg
     6121 cgggggcgtg tccggccggt actccgaacc catcacgtac cggtagagca cgggttcgtg
     6181 ttcgatgagc cattcggcgt agtcgagcga ggcgccgtcg ccgatctggt ggctggtgta
     6241 gttgaagagg cggcagtaga agtgatccgc cgccgccccg tcgtgggtgt tgagatccgc
     6301 gccgctgaag gtgttcggca ccccggtcgc gaactcccag gtggcgggcg gctcccagaa
     6361 gacgacgtgc gcgccgcacg cgtcgacggc gtggacgatg ttgccgcgat gggggatcgc
     6421 caccggcccg agcgtgaccc ggccaccgag actgtcgacc cattcggcgg ccgcggccgc
     6481 ctgtggcacc gagatgtgga cgctccagcc tgccgggccg ccggtagccg cgcggtacag
     6541 accaccggcc gggacgccgt tcagcgtggc gatcgagtaa cggccggtcg gtgtcgccgg
     6601 atcgcgctgg acgacgtact cccagtcgaa aagcccgctg tagaaggttt gtgcggccga
     6661 ttcgtctctg cacgcgagct cgatccagca cgggattccc gaaggtatga cggaagtgtg
     6721 ggcggccgag ccgagcgaca tgcggttctc ccttaccggt gggagtaaag tctagtcgct
     6781 gaccgcattg tttccgtcaa agatttcgac cggacgaccc cggaacccgg cccggtgtcc
     6841 cttcgttgga gcttccgtgc gctggtttcc ccgagccctc tcctccttcc gtcgcggcgg
     6901 tgaggaggtg ctgccgagcc cgaacatctg gtactaccag aaggcctacg aggtcgagaa
     6961 tcgcgcgcag gacgtcgacg acgagatctg gcgcgtgctc gccgggtatc gcgattggtc
     7021 cggcgcggac gtcctcgaca tcggctgcgg tgacggtttc catctgccgc ggttcgccgc
     7081 gacggcgcgg tcggtggtcg gggtcgaacc ccatgagccg ctcgtcctcg acgcgcggaa
     7141 acgggtggag cgactggaga acgtcgaggt gcggcagggg cgtgcccagc ggcttccctt
     7201 accggacgcg gctttcgacg tcgtccacgc gcgcaccgcg tacttcttcg gccctggttg
     7261 tgagcccggt cttcgcgaag cggagcgggt gctgcgtccg ggcgggctgt tggtgatcgt
     7321 ggatctcgat gtgacgagtg agccctacgg acgctggatg cggctggatc ttccgcacta
     7381 cgacccgccc ggggtggaga agttcttcgc ccgtcaggga ttcggctgcc gcaaggtgat
     7441 gacgcggtgg cagttcgagg acgccgccgc gatggaggcg gtgctgaaga tcgagttcag
     7501 cgctccggtc gcggcgaagg cgatcgcgga cgtccggcgc ctgaacgagg tttcgtcagg
     7561 tgccggggag aagcggatga cgctgccggt gggctatcgc gtgcataccc gcgtcaagcc
     7621 caccggcctc gtcgtgccag gtcactccgc gtcctcgtcc ggagtggcgt cctcggcctc
     7681 accgaggatg ccgtagatcg tccggcgtgc ctcgttgagc acgtcgacgg tgcgggcctg
     7741 ctggctttcg ctgccggcgt gcatcacctg cgcgaccgcc gcggccaggg tcgcgccggc
     7801 cttgcggagg ttgacctcgg ccgggtcgac gtcgtgggcg atctgctccc acggcgggac
     7861 ggcgtcctgc tgctcggccg cggcccggcc ggattcggtg agttcgaaca gcttcttgcc
     7921 gttctcgtcc ttgctgatca ccaggccttc gtcggccagc aactgcaagg tcgggtagac
     7981 cgagccgggg ctcggcttcc agaagccgcc gctgcgttcg ccgatctcgc ggatgatctc
     8041 gtagccgtgc ctcggctgct ccgacagcag cgccaggatc gcggcgcgga cgtcgccgcg
     8101 tttgccgcgc cgcccgggac cgccgcggcg gccgtgccgg tgccggtggc ccggtccgcc
     8161 cggaccaggc gggaagtcgc cgaagccgcc gcgggaccaa ggtccgaagg cgggccggcc
     8221 gtgttctggg gggaagggtc gtcgcatgag gtgaatcctt tctacgtact gtctcgacac
     8281 gttcacgata tatcggaaac agtcgcacgg caacccgttt tgggtgatct ggctctcagg
     8341 agaggtcgag cgcgagcaga tcgatgccgc cgaagtcgaa ctcgccgacc ttccgccagc
     8401 cccagcgccg gtacagccgc cgggcgggag cctcgacgcg ggacgcgagt acggcgaacc
     8461 gctcgggccg ctctttcagc aggtcatcga gcagagcgcg gccgagcccg cgaccgcgga
     8521 gctcggggag gagcgccagc tcgtacacat agaacagcgc ttcgccgtcg agccacgacg
     8581 gcgccggagc cgtcgcgcgt tcgggccacc agccgatttc ctgccggact ccgtaggcga
     8641 agccgccgag tgctccggcc tcgcgcaccg tcgtcatggc gaacccgggg agcgcggcgt
     8701 gttcggcgaa cagcacgccg aagcgggcga cgtcgtcctc gccttcgagg tacggcggtt
     8761 cgcggtagac gcggcggtag acgtcgtcca gttcagagcg cacggttcag tctgcccagc
     8821 accacgatcg ccacgccaca acagccgatc agcaccagcc acggcagagc cgcaccgtgc
     8881 gacagcagcc aggtgaacgt cgccggagcg atcacccgcg caacgctcca cacgagttct
     8941 tcgaggccga gatagcggcc gcgcagccgc gccggggcga tcgcgaccgt cagcgcgctg
     9001 ctggtcggcg cctggagcag ttcggcggcg gtgaagacga tcatcgcgag ggtgagcacg
     9061 aggaacgccg tcgtgggccg cccggtgggc accagcgcga acaggacgaa cgacaccgcc
     9121 cacaccgcgg ccgagacctg gagcgtgcgc ggcatgcgac gccgctcgac ccggcgcgac
     9181 accacggtct gcgcgagcac gaccagcacc gtgttgatcg cgaacaggac accgggctgc
     9241 caagccggca gcttcaggcc gtcgaggacg tacgcgctca gcaagacggt caacgccaga
     9301 tcgcacaacg cgaagacgaa gacggtcact agaacgcccc ggaagatccg gtcggcgagc
     9361 accttccggt agccgccagg gggaacggcc tcggatccgc tctcgcgagg ggtgcccgcc
     9421 ggggctcgcc acgaggcgac cagaaccgcg gcgacgacga aactcgccgc gttgaccagc
     9481 acgatcgtcg tgtagccgcc gggcccaccc caagcgacca tcgcggcgcc gagtagcccg
     9541 ccgagcccga tgccgacgtt gcgcagcgcg cgttccatcg cgtaccagcg ggcgcgctga
     9601 ccctcgtcgg cgacctgtgc caccagcgcg ccggtcgacg gccagaacat gccttcgccc
     9661 cagaacgtga tcgcggccag gacgaccaga tgccaggcct cgccggcgaa gacgtagccg
     9721 gtgaaggtca ccgcgcggat caggttggcg gtgatcacca tccgtcccgg cccgaaccgg
     9781 tcgatcagcc gtcccgcgag cggacccgac ggcagcgcga tcatcgccgc gatcgacagc
     9841 gcggctccga cggccgtgag cgacagaccc ttcgccgcgt ggaagtacac gacggcgaac
     9901 ggcaggaaca aaccggtccc cagcgcgtcg acgctttgcg ccgcgatgag cgggaaccgg
     9961 ccgcgagtgc tcgggagccc gagcaggtcg gcggcggcca tcacgcgtgg gggagcggga
    10021 agacgttgag ttcgtgctcg gcgagcggtt cgtcgcgcca gccgagcgcc actgccgcgt
    10081 cggcgatcct tccgttgccc cacaacggag aaccggcggg gaagttcgac acgagccccg
    10141 ggaccagcgt atgcgcggca tggaatccgg cggccgcgac gtcgcaggtc gtcaggtcta
    10201 cgctgatcac ctcgaatccc cgggcttcga cgcgggcttg gtaggccttc agccgccgtt
    10261 ccccgagggc gggaaggtcg tcccagccac ggctcggcag gtccctgagc cagggcgcca
    10321 ctcgcttcac ggcccgtggg tcgagataga tctgttgctg gcaaaggaga tccgcgacgt
    10381 cggcgaagtc ctcgcggtac gagtccaggt agcgccgatc ggcccggtgc ggtttgaggt
    10441 tgcccagatg cggcaggtcc cggcgcatgc ccgccagttc gcgttcgtcg tcgagggcgc
    10501 ggcaggtgtg ctggagcgtg aacccttcgg cgagcgcctt cttcgcggcc tcgagcgcgt
    10561 ccggccgggt cgcgaaaccg atcgacagcc agcgtttcac gcggtcgagg accaccgctg
    10621 cgaccaccgg gacgtcgaac tcgttgtcca ggtggatgag cgtgacctcg tagtcgtcgg
    10681 tggcgtcggc gatgagcgac cggatctcgt ccgggatcga gagcctgccg agccgtggcg
    10741 tgttggccca ccaaagcatg gtggtgtcgc gttcgaggac ctcttcgagg ccggaggtga
    10801 cggcgtgctc ctcggtggtc ccgctcgcga ggccggcgat cagcggatcg gcgaagtacg
    10861 cttcctccgg ccgtcgttcg ttcgagaaca ggaaggccgg aacccagacg ggttcgccgg
    10921 tggtgtggga gaagccttcc acccaagaac attccgtgtc ctgggtcagt ggcgcgaacg
    10981 ggaaacccgg cgaccggtac tgcgtggccg aatagaggtt cagccgttgc gggtcgagtg
    11041 cggggacgcc gtagcggaag aattgcttgt agctgccgaa gcacacttcg cgctccggag
    11101 cgagccagct tccgcagtag cgctccaccg cttcgccgat ggccgactga cgcgcgaggt
    11161 cgaagtcgtg ccaagacgtg ccgaaggcct gacggtcgtt gggccagttc gtcacgcggc
    11221 gcatgtccgc gacatcgacc gcgcagaccc gcagccgggc gggcattccc ggcgcgggcg
    11281 ggatctcgcc gacgccggtc acgatcccgg tctggtcgtc caccagcagt ccggggtcgg
    11341 tcgtggcggg aacgggccgg gcccggtcgg gtacggggag gatcggacgg cggatctcgg
    11401 tgaggtccgc cgggttgagt tcgatctcgc cggtggtcag gccggagcgt ccgccggaga
    11461 gccagtgttc gagatggacg gcgagggtgg tcagcgccca gcgggcgtcg cccggccgaa
    11521 gcgggatgga gtccgagggg gccgagagga acgcttcgac gactcgcggg tcctgtgcgg
    11581 cggagcggcg ccgcgcgacg acgtcggcga aatcgatgcc gccgggcgcg atcgcgggtc
    11641 cggcgatcac ccggccgcgt tcgcggcgca acggcagcca gcgcaccccg ctgccggcgc
    11701 acaacgcgtc cagcgcgatc agttcggtgt aggcggggtg atcgaaggcc gcgaccacga
    11761 cggtgttctc cgtgtccact tcggacagat cgtggaagta ggggaccgtc tcgacgctcg
    11821 cgtacccacc gctgtggagg atttccgcca acggctcggt gagcgcgggc gagccggtga
    11881 gcaggatcga ggtggcggcg acgtcgtcgt ccccggtgtc acggccggag ctgaggcagc
    11941 cgtccgcttc gaggatctcc atcatctcct cgtagtccgg atccattccg gccagcagtt
    12001 cggcacgggt gctggtgccg tcgcaacggc tcgcccaggc acggaactcc cgggtcggcg
    12061 cggcgatgta gaactggccc ccgttgggcg tgacgagaaa gcagagctcc ggttcgagat
    12121 cggtgatctc gattccgtcg agccgcggtc tgacctcttc ggaccccatg gcaaccccat
    12181 cgtttccagg actcccgcct cgccgccgcg gtccagggcg cgggaccgcg gcggcgcggg
    12241 cggcgttgtc ggccggttta cttggcggcg gaacggttgt ggacgaccgc gcggttgtgc
    12301 acgacggccc ggttgtggac gaccgcccgg ttgtggacca cggcgcggtt gtggacgacg
    12361 acggcggcgg ggcgctcgaa ggtcgagatc atgggtcctc ctgattttca ctcggggtcg
    12421 tcacgctccg tggcgcgaca tgaccaagtc tcgggccgga cgtgacctcc cgacgtctcc
    12481 tgatgtgcga tccgcacgga cggcccgggc acgcttcacg tgacctggaa aacagcgatc
    12541 cggggcggcc aaggcgcgtc gaaggtggac atgggacact gagtgagcta tgactgccct
    12601 ccctctcgtc ttcgacgcgc ccaagcgcgg ccttccgccg cgccacctcg ccgacctttc
    12661 cgccgccgag cgggccgctg ccgtcgccga gctgggggag aagccgttcc gcgcgaagca
    12721 gctttcgaac cattacttct cgcggctgac ggtggacccg gcggagatga ccgacatccc
    12781 ggcggcgtcg cgggagaaac tcgtcggcga tctgatgccg acgctgctca ccgagatcaa
    12841 ggcgctcgcg tgcgacgacg gcaccacgcg caagacgctg tggcgcgcgc acgacgggac
    12901 gctcctggag agcgtgctga tgcgctaccc ggatcgggcg accctgtgca tctcgagcca
    12961 ggcgggctgc ggcatggcgt gcccgttctg cgcgaccggg cagggcggcc tcgaccggaa
    13021 cctgtcgacc gcggagatcg tcgaccaggt ccgcgccgcc gccgcggtga tgcgcgacgg
    13081 agcgatgccc ggcggacccg gacggctgtc gaacatcgtc ttcatgggca tgggcgagcc
    13141 gctggccaac tacaagcggg tggtggcggc ggtccggcgg atcacggatc cctcgccgga
    13201 cgggctcggt atcggacagc gttcggtgac ggtgtcgacg gtgggtctcg cgccggcgat
    13261 ccgcaagctc gcggacgaga agatgcaggt gcggctggcg gtttcgctgc acacgcccga
    13321 cgacgagctg cgggacacgc tggtgccggt gaacgagcgc tggtcggtgg acgaggtcct
    13381 ctccgcggcc cggtactacg cggacacgtc cggccgccgg gtgtcgatcg agtacgcgct
    13441 gatccgggac gtcaacgatc agccttggcg tgccgagctg ctggcgaagc ggcttcgcca
    13501 gcacctgggc cagctggtgc acgtgaacgt gatcccgctg aacccgacgc cgggcagcaa
    13561 gtgggacgcc tcgccgaagc cggtggagcg ggagttcgtc cggctggtga acgcgggcgg
    13621 tgtggcgtgc acggtccgtg acacgcgtgg tcaggagatc gcggcggcgt gcggtcagct
    13681 cgccgccgag aactgagttc ttcctttcag tgatggagat tttgtcgtga tgtatgcccc
    13741 cagcctgctg gatccggctg cggaggagct gaagctcacg gacgtgatcg gccacggcgc
    13801 gaccggtgtc gcgcgcgagg ccaggacgtt gctcggtgag cggttcagct cggtgacctt
    13861 catgtacgtc ctgatgcggg cgttcgaggt ggagtacatg gcggcgcggg acgcttcgcg
    13921 gtggcacgag ttccacggcg ggccgtacgc gttgtccgac gccgacctcg aagccgtgct
    13981 ggcgccctgg ctcggttccc gccgctagac cgcgaggtga caggatgcgg gcgtgtattg
    14041 cctgcaggcc gtcgtcgtca ccgagtccgc acgcgctgaa ttgcccgctt cggtcgaggg
    14101 cgcgcggctc gtcccggtcg ggcatcacct gtcactgatg ccgttgcccg agacgctgcc
    14161 ggaagccggg gaattccgga ccgtgctcgc agcgtgctcc gagcacggcg ccgtggcgta
    14221 catcgaggcc gagtacttcg gtggtgtcgg gacgcaatcc gcgcaggtgt gggaccgcgg
    14281 cgagacggtc ctcggcccgc tgcaccttgc cgaggacgag ccggccttgg ccgccggcag
    14341 tccgatttcc caggcgcttc ggcggctcgg cgtggccaag ggcgaccact tcgacgagtt
    14401 cgacgccgtc gggctcggca ggcaccgcca caccggcgat tagctctcct cctagcgatc
    14461 cactcctcct ctgccgctgg gccggacggc ccagtcacgc ggcggtcatg gccatcggcg
    14521 gcgacactcg atggagactc acgaggaggt ggaccggatg tccgcgacca aggcgagaca
    14581 ggtgcgccac aacacggccg tccaggtact cggacggatc gggatgggct gctacggcct
    14641 ggtgtacctg ctcatcgggt acctggcggt gcgcgtcgcc gtcggcggtg gcggccagga
    14701 ggccgacggc cgtggtgcga tcaccgaggt cggctcgacc ccgatgggcg gcgtcctgtt
    14761 gtgggtgctg gcggcggggc tggtggccta cggcctgtgg caggggctgc tggccgctgt
    14821 cggttacacc tggatcgaca agcagcgaaa acgcaccgtg aaacgggtga cgtccggcgt
    14881 gcgctgcgtg gtggggattt ccttgggcgt ctacgcggcc agggtcgcca tgggctcggg
    14941 ggagcagggc agcggcgacc agaaacagca ggagttcacc gcgcggctgc tcgggttgcc
    15001 cgccgggccg ttcctggtga ccttggtggc cgtcgtcgtg ttcggggtcg cggtgggttc
    15061 ggtggtgaag ggcgtgcggc ggaccttcct gcaggatctc gacctctcgc ggctcccgtc
    15121 ggggacgcgg cggtgggtcg agcgcctcgg caggatcggt tacgtggcaa ggggtgtcgt
    15181 attcggcgtg gtcgcggtac tcgtcggcta cgcggcgctg acgcacgacg cggcccgctc
    15241 cggcgggctc gacgcagccc tgcggacctt ggccgctcag ccgttcggca cggtactgct
    15301 catcgtggtg gccgccgggg tcgcggcctt cggcgtgtac tgcgtcgggg cggcacgggc
    15361 ccagcgcggc tgacggcgcg gccttgtccc gccccggaac cgaggcggga caagggaact
    15421 actcgacggc cagttcgccc agctccgacc aatcgtcctg atcgaccttc gcgttgacga
    15481 tgcgcggcgt ctcggccagg taccgcggaa gctcgcgctg ggccgtgcgg aaatgttccg
    15541 aaccgacgtg ggcggcaccc gcctcgtcgt cgcggaacgc ttcgacgagc acgtattcgt
    15601 ccgggtcgtc gaggctgcga gcccagtcgt accaaagaca accgggctcg gcccgggtcg
    15661 cttcggtgaa ctcgcgcgcg atctccggcc atcggtccgc gtgttcgggg cggacccgga
    15721 acttcgccgt gatgaagatc atgagaactg gattcccccg tcgatcatca ccgattggcc
    15781 ggtcatgtag tcggaatccg gcgaggcgag ataggagacg tacgccgcca cgtcctcggg
    15841 aacggagacg cgcccgagat ggatcaggtt cgagtacttc tcgatcgcct gtcccttccg
    15901 gattccttcc gattccgcca gtttctcgtc gatgaggtcc cacatggccg tcccgacgat
    15961 gccggggcag tacgcgttga cggtgatgcc gtggcgcgcc cattccatcg cggcggcctg
    16021 ggtcagcccg cgcaccgccc atttggacgc ggaatagtgg ccgagcaacg cgaacgggcg
    16081 atgggcgacg atggaggccg cgccgatgat cttgccgccg ttcccctgcc ggatcatctg
    16141 cttcgccgcg gcctggtaac agaggaagat gccgcgcgcg ttgacggcca tcatccggtc
    16201 ccagtcctcc ggggtcactt cgagcagcgg caggacctgc gcgatccccg cgttcgccac
    16261 catgacgtcg agggaaccca gcgcgccggc ggtttcggcg accatggcgg tgaccgattc
    16321 cgagtccgcc acgtccgcag tgatcgccgc ggagcgccgt cccgtttcgc ggatctcctt
    16381 ggcgaccgct tcgagttccg cttcgtgggc ggcgacgtcg ttgaccgcga cgtcgtgccc
    16441 gtcggcggcg agccggagcg cgatcccctt tccgattcct cgtgccgcac cggtgacgag
    16501 tacgttcttg ctcatgcgat gactcccttg ttcgcctggg cttgaacgga aggtaggggc
    16561 ggcgacggca gcttgggagt ggcctcgtgt ctcactttga gacacggcga tcagagcgac
    16621 gacgcggcgc gatagtcctt cggcgaggtg ccgagaagcc gggcgaacat cgtggagaac
    16681 gcggcggggc tctcgtagcc gagcgaggcg gcgatcccgg cgatgggaag accgtccgac
    16741 agcagcgaga gggaatgcag gacgcaggcc cgctgccgcc agcgggcgaa acccatcccg
    16801 gtttcggtgg tgaagagccg gttcagcgtc cgctcgctca cgtgcagccg ggcggcccag
    16861 ccgccggccg gatcgtggat gtccggatcg tccaaaaagg actcgcacag ggcgcgcagc
    16921 cggtcgtgct tgggcagcgg gagatcgagg cggaccgggg cggcccggcg gatctcgtgc
    16981 agggccaggc cgatgaccgc ggcgtcccgc ccgcgcgggg tgtacagctc gggcacgccg
    17041 acggcctcgt tcaggagttc gcggagcagt gcggagactt cgacgacctg gcagcggcgc
    17101 gggaaccacg gcaccgcctt cggctcgatg tacaggctcc gggtgctcac agtcgtggtg
    17161 aagacctgat ggaccgtttc cggcggcacg agcaccgccc gccgcgtcgg gatggtccac
    17221 gtgccgtcgg ccgtttcgac ccgcatcgat cccgtcgcgc tgtagaggaa ctgcgcccgc
    17281 cggtgccgat gcggcaggat ccggtgcccc ggcgggtaat cggtgcggat ggccaccacc
    17341 gcgcggtcga ggtggtcgac ctcgtcgatg gggatgtcgc gcacctcacc cagcgtacgc
    17401 cggatgtccg atacgcgaaa gaaagtggcg ttctttcgaa tgcccgccgc gcccagggcg
    17461 cctaccgtcg caggagtgct gatcgagatc gcggtgctcc tcgggttcgg ctgcctgagc
    17521 ggggtcacca ccgtcctttt cggattcggc ggcggattcg tcaccgttcc cgtcgtctac
    17581 gccttcgcgc tcgccgaccc ggagaacgcg tcgtccgcga tgcacgtggc ggtggccacg
    17641 tcgaccgcgg tgatggtggt caacgccggg agcgcgaccg ccgcgcaact gcggactgga
    17701 cggcttcgcc gcgactacct gtggccgctc atcgcgttca tcggcctggg cgccgtgctc
    17761 gggtcgttcg cggcgaccat ggccgacgag ggcgtgctgc gctggctctt cgtcgcttat
    17821 ctcgcgctga ccatcgccga cagcgtggcc cggaaggggt tcgtgagcag gcgggacgac
    17881 ggcaggccgc gtgcgctcgg cgggttcacc atcagcgcgg gcgggatcgg aatcggtgcc
    17941 gtggcgagct tcctcggggt cgggggcagt gtcctcaccg tcccgctcat gcggcgcaag
    18001 ggtttgccga tggccgacgc ggccgcgctg gcgaacccgc tgagcctgcc ggtggcggtg
    18061 atcggcacgg ccgtctacgc cttcgcggcg acgggtccgg ccccgggcgc cgcccatctc
    18121 ggctacatcg acctggtggc cgcgggcgcg ctgctgtgcg ggtcgctgcc cgccatcgcc
    18181 gtgatccgcc gggtggtcgg ccgcatcccg gatcgcgccc acgccatcgc gtacctcgcc
    18241 ttgctcgcca ccgcgctgat agcggtcgtc gtccgttagt gatccgatga gttcggctca
    18301 tgtcaagcct tgacaaggcc tcaccgggat ggcaaggggt tatcgacagg caaagatccg
    18361 acgaatcctc tatacctttg ggggaacttg cgccaagatc tcccgcatga aactgagatc
    18421 gatcaccaaa cgcatgttcg ttctcggact gctgacggct ctcgggacca ccggggcgac
    18481 gtcggtggcc accgccgaac cccagctgcc gcctgccgag gtcaacgcga ccggacagcc
    18541 gcacggcgcc tgggacccgg tcggcccgaa cagcgtcggc gggctgctgg cggtttcacc
    18601 cgctgggctc gcgatgatgg tgcccggccc gcccgccctg tggctctccg gcgaccgcgg
    18661 cgcctcgtgg accgtgcgca ggggcctgcc ggcggacacg tccatccagg gattcttcgc
    18721 cgatccggtg aacccggacc ggatgctcgc ggtgggcaac tcgcccggcg ggatgcccgg
    18781 cgagtggcac gggatgttcc tgcggaccac cgaccgtggc cagacctggg agactctgcg
    18841 cgagtggtac cccgacggcg cgttcgggat ggccacggac ccgacaggcc gggtcgtcgt
    18901 ggtgcagaac ctcgactcgc tgagcgtcag catcgacggc ggcgaaaact ggaacgacgt
    18961 gccgaggacc tggccgcgcg aagggatcgc ctcgccggtc ggcgcgctca agctcacgat
    19021 ggtcggcgac gacgcctact tcacgacggt ctaccccgaa tacgcgctct gggtggttcg
    19081 cggggtcagc ggcaaggagc cgaaggccga actcgtctac cggacgaacg gcgaggtcaa
    19141 tcaggtcgcc gcggacggcg ggcgcctcgt ggtcacggtc ggctccgaac tgcacggctc
    19201 caccgacggt ggcaagacct ggacggtgct gcgccgcgag cccgccgggc agaccctgcg
    19261 cgaaccgcgt ttcgtcggcg gacggctgta cgtctcgacg tataacgaca tagacgtcag
    19321 cccggacttc ggccgcacct ggatccgcaa accggtgccc gccccgggcg aaggcgtcag
    19381 cgacatgatc gagcttcccg ccgcgccggg caaacccgcc accacgctga tctcctcgct
    19441 gtaccgcggc gtgtacgccg atggcggcaa gagcggatac cagcagatcg gcgtgcccgg
    19501 tgagaccatt cgcgacctcg tgaccaccgg gaacctcctg cgggagagcg tcgtcgcggc
    19561 cggtgtgcag gagatctaca acaccccgct cccgcgcggc aaggtctccg cgacggaccg
    19621 ggtctggcag tcgcacccca ccgaccggct gcacgaggac gcgagcctgt ccgtctcgcc
    19681 gggccgcccg gacgtcgtct ggcaggtcac caggaacggg ttctcgctcg acgtgctgcg
    19741 cagcggcgac ggcgggcgga gctggcagtt cgcggcgaag gcgaaggaag ggctccccag
    19801 gacgatcttc gctcacccgg ccgatccgga ccggatcatc gtctcggcct tcgcgcccag
    19861 cggttacgtg ctccaccgca gcgacgacgc cgggaagacc tgggaaaagc tctcggtcga
    19921 cagtggcttc accacgttcg ccggtgatcc gtggaacccg aaccgggtct ggggcgggga
    19981 ctccggcggc ctgtcccggt cggacgacgg cggcaagacc tggacccacg tcacgagcca
    20041 accggtcagt tcgatctccg tcagccggtg gggtggcggc cgcgtgctca tcggcggcgc
    20101 gggcatccac ctgagcgagg acggcggccg gacgttccgc cgggtccgcg acggcgagga
    20161 cccccgtgag atcagccgca tcctgccgca tccgttcgac ttccgggtgt ggttcgcgag
    20221 cgacgcgacc gggggaggcg tgctgcgcag cacggacttc ggccgcacct ggtcgcccgt
    20281 gcccggcgcg ctgcccgatc ccagggtgct ctccctggcg atcagcgcgg acggccggta
    20341 tctgttcgcc ggcaccgcgc agtccggcgc gtaccggttg aagctgtact gagtcctggc
    20401 gcttcgtggc cggagaaagt tccggccacg aagcgtttac tcggtccccc gtcgaatgtc
    20461 agagtcgagg gcatggccat cgacgtcgcc gccctccggc tgcacttccc ttccctcgcc
    20521 gacggaaccg ccttcttcga cgggcccgcg ggtacccaga caccccggcc cgtcgccgac
    20581 gccatcgccc ggacgctcac cggtccgctg tcgaaccggg gcatggtcag cccgtccgaa
    20641 ctcaacgcgg agaacgccgt cgccgcgttc cgtgccgcgt acgccgactt cctcggtgtg
    20701 cccgccgaag gtgtcgtcca cagccgcagc gccactcagc tgacgtacga cttttcccgg
    20761 cacctggcca aaaactggcg tgcgggcgac gagatcgtcg tcagccgtct cgatcacgac
    20821 gccaacgtcc ggccgtgggt ccaggccgcg gaccgagccg ggatgaccgt ccgctggctc
    20881 gacgtcgatc ccgagaccac cgaactcgac ctcgatacgc tggtcctcac cgaaaggacg
    20941 aagctggtcg cggtcacggc ggcctcgaac gtcctcggca cgaagccgcc gatccgccgg
    21001 atcgccgatc tcgcccacga cgccggggcg ctggtgttcg tggacggagt ccactacgcc
    21061 gcccacgacc tggtggacgt tcccgcgctg ggagcggatt tcttcgtctg ctcgccctac
    21121 aagttcctcg gcccgcactg cggggtgctc ggcgcgtcgc cgtcactcct cgaaaccgtc
    21181 gagccggaca agctcatgcc gtcgcccgac accgtgcccg aacggttcga attcgggacg
    21241 ctgccgtacg aaatactcgc gggcgcgacg gcggccgtgg acttcctcgc cgcgctcgac
    21301 ccgggatcgg ccggatcgcg gcgggcgcgg ctggcgaact cgatgaactc gttgcacgag
    21361 cacgaaagcc tgctgctcgc ccggttggag aagggactgg gcgacgccgt caccgtccac
    21421 ggcaaggccg ccgaccggac gccgaccgtc ctgatgggcc tcggcggccg cgagcgcgag
    21481 gcgcaggagt acctcgccga gaggaacgtc gtcgcaccgg cgggatcctt ttacgcatac
    21541 gaagtcttcg cggccctgaa gctggaggac cccgcgctcc gcgtcgggct ggcaccgtac
    21601 accagcaccg aggacgtcga caggctgctg gacgggcttt cggctttcgg gtgacaggcc
    21661 acagtggaca gtgcggtgac ctgcaccgga cgggctccgc cgcgtgtcgt ccacctgatc
    21721 acgcctgtcg tccgttcgga cacgcgaatt tccgtaactc gaacaggttg gatttccgcg
    21781 ccgtcgccgg gagccgtatt accgttcggt catgatcgac aacgggaggt tcgcgatgcg
    21841 tttccggtcg gtggccgctt ctgtccttct cggttgcgcg ctgtgcgtgg cgcccgcggc
    21901 actcggggcc ggggcgcggt cgctcgcgat ccagccctgc cccgaggtca acgatccgcc
    21961 cgactacacg atctcgaacg gcgccaaggc ctggatgaag acgaatctcc gcagcgacta
    22021 cctgcgcggg ccggggacga tcacctacaa caagaccacg acgtcgtcgg tcaacgcgtc
    22081 catcaccggt acgaccagtg ccgaggcggg cgtcatcttc gcgaaggcga gtgtctcgct
    22141 ggccgtgagc gtcggcgcga gctactcgaa gtccgattcc tggtcctatt ccgcgacggt
    22201 gcccgccggg aagacgttgc ggttgcagca gtacaaggaa gcgcgctcgt tcaccgtgca
    22261 gaagtaccgg atcgtcccgc cgtgcaaggt caagtacctc tggaagaaga acgccgtcgc
    22321 gccggtcaag agccccagct acctgtggca gctgatcggc tgaccccggt tttggggccg
    22381 atcacaagac tcgttcgccc gatcttgtga tcggccccat ggacctacgg tgaccgtgcc
    22441 gacacgctgg gaggtgcgtc gcgggcaacg gggcccggac ggaacgggac ggtggccacg
    22501 atggggagac ttcgcgcacg gatactgatc gccgggatgg tcgcgctcgc gaccgtgggc
    22561 atcgcgcccg ccgcgacggc cgagaccggc atcgcgagcc ggtggagtga accagggccc
    22621 tacacggtga cagtcgaagc cctcgacagc acgcatacca tgtaccggcc ttcgcggctg
    22681 gagaagcacc cggtgatcct gtggggcaac gggaccggtg ccggcccgaa gatctatgac
    22741 ggcttgttgc ggcatctggc gtcccacggt ttcgtggtcg cggcggccga cacgccgaac
    22801 gcgggttccg gtcaggagat gctggccggg gccacgaccc tgatcgccga gaactcccgt
    22861 cccggcagcc cgtaccaagg gaagatcgac acggcgcaca tcggtgccac cggccactcc
    22921 cagggcggcg gcggggcgat cgtcgccggc gcggacgccc gcgtcaccac gacgatcccg
    22981 atcgaacccg gaccgcaggg ctcggccgcg gcgctgaagg gtccctcgtt cttcctgggc
    23041 gggcagttcg acaccatcgt cgttcccggg ctgctggtca ttccgcggta ccgcctggcg
    23101 gaccaggtcc ccgcgatcta cggcgaactc ggcggagcga cccatttcac gccggtcggc
    23161 gacgggggcg ggttccgcgg cgcgatcacg gcgtggttcc ggttctggct ctccggcgac
    23221 gagcgggccc gcgcggagtt cttcggcccg tcctgcggat tgtgccgtga cggggcgtgg
    23281 tccgacgtcc gtcgcaacgc gaaggcgctg gccgtcccgg gcgcttgatc gacggatctt
    23341 gtcggtgccc ggggttaagg tctgccacag cagcctgacc tggagggata tccgcgatga
    23401 ccacactcgt caaccggccg aacaccgcgc tcctcgtcgt cgacgtccag aacggcgtcg
    23461 tcgacgaggc tcacgagcgc gacgccgtgg tcgcgaaaat cggcgggctc gtcggcaggg
    23521 cgcgcaggga aggcgtgccg gtcgtctggg tgcagcattc cgacgatgaa ctcgtgcggg
    23581 acagcgaaga gtggcgcatc gtcggcgagc tggaccgtga agactccgag cctctcgtcg
    23641 aaaagtccta tggggactcg ttcgaggaca ccgatctgga gcaggtgctc gccgag
//
