LOCUS       NZ_CP102415            22544 bp    DNA     circular CON 26-AUG-2024
DEFINITION  Amycolatopsis roodepoortensis strain ZEL-1 chromosome, complete
            genome.
ACCESSION   NZ_CP102415
VERSION     NZ_CP102415.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis roodepoortensis
  ORGANISM  Amycolatopsis roodepoortensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Biodegradation of petroleum hydrocarbons by Amycolatopsis orientalis
            ZEL-1, genome analysis and its potential in plant protection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2022) College of Life Sciences, Sichuan Normal
            University, No. 1819, Section 2, Chenglong Avenue, Longquan
            District, Chengdu 610101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024628825.1-RS_2024_08_26
            Annotation Date                   :: 08/26/2024 06:13:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,064
            CDSs (total)                      :: 8,994
            Genes (coding)                    :: 8,928
            CDSs (with protein)               :: 8,928
            Genes (RNA)                       :: 70
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 27 of 66
            Pseudo Genes (incomplete)         :: 44 of 66
            Pseudo Genes (internal stop)      :: 4 of 66
            Pseudo Genes (multiple problems)  :: 9 of 66
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:48:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4458403
            Orig. end                         :: 4480947
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102415.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22544
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="19"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22544
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22544
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12544](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12544)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            310..972
                     /locus_tag="NQK81_RS21015"
                     /old_locus_tag="NQK81_21015"
     CDS             310..972
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104840.1"
                     /locus_tag="NQK81_RS21015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21015"
                     /product="response regulator transcription factor"
                     /protein_id="WP_126732312.1"
                     /transl_table=11
                     /translation="MTTVFIVDDQALVRESFAGLLNAQPGLDVVGQAGDGIAALTDIAA
                     LATPPDVVLMDIRMPVMDGLEATRRLLEGDGEKPKVLVLTTFHLDDYVYEALRAGASGF
                     LLKDAPSAELINAIEVVAAGDALLSPAVTKRLIANFVASAPVPRPSPARFDVLTERERE
                     VLRLIAKGRSNPEIAADLVLSAQTIKTYVGRILAKLGLRDRAQAIVLAYEAGLVSPA"
     misc_feature    311..325
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    910..912
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(942..1652)
                     /locus_tag="NQK81_RS21020"
                     /old_locus_tag="NQK81_21020"
     CDS             complement(942..1652)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS21020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_21020"
                     /product="hypothetical protein"
                     /protein_id="WP_257489448.1"
                     /transl_table=11
                     /translation="MNGKTGRWIGGVALILAPLVWCAGLLLRHLVLKDFTPEQVAWFDQ
                     QPFAAPGQLAAYAANPGFVTAAYSLFLLGAVLLLPAFLMLAKIVAAKAPALAAWGFLLL
                     AFGLFARVYFAGVELTAFELVDKLGLDHATKLVMDDYVDLSYGLWRIPVTASVGQYAGG
                     LLLAIGAFRAGTFGIVRALLFLWPCTLWMGVLKESELLSVFTAVALGLALVPLGVRVLT
                     RPADRQAGETSPAS"
     gene            complement(1864..2067)
                     /locus_tag="NQK81_RS21025"
                     /old_locus_tag="NQK81_21025"
     CDS             complement(1864..2067)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222289.1"
                     /locus_tag="NQK81_RS21025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21025"
                     /product="cold-shock protein"
                     /protein_id="WP_005163378.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDNGGGDVFVHYSEIKGNGFRTLEEN
                     ARVEFEIGQGAKGPQATSVTVI"
     misc_feature    2115..2130
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(2122..2137)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.25"
                     /tool="antismash"
     gene            complement(2316..2486)
                     /locus_tag="NQK81_RS21030"
                     /old_locus_tag="NQK81_21030"
     CDS             complement(2316..2486)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163371.1"
                     /locus_tag="NQK81_RS21030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21030"
                     /product="hypothetical protein"
                     /protein_id="WP_185927051.1"
                     /transl_table=11
                     /translation="MADETKPQDKSVSGVVPVQFSADAETHDIAVVATNREALRRSPFG
                     TEVPLRAASGE"
     misc_feature    2671..2680
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(2744..4366)
                     /locus_tag="NQK81_RS21035"
                     /old_locus_tag="NQK81_21035"
     CDS             complement(2744..4366)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222288.1"
                     /locus_tag="NQK81_RS21035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21035"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_063275110.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.5e-35, bitscore:
                     121.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.5e-34, bitscore:
                     117.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILTEAQIHRVYAVVGESFLDLLDALQRERSITFVSARHDSGAA
                     FMAEAEGKLTEHPAVLLAGRGPSAANLAIGVSTAYQDESPMVVLLENPPQDPGPTSELP
                     TADLTAMFEPISKWTGRAESPDEVPGLLVEALTRCREGRPGPTVVAVPADFWGVPFDSA
                     KPVAAVRPPATGALGRTAEAVAQLVDEARYPVVIVGGRARAARDELIAVADELALPVYN
                     AFRRQDAFPENHARYAGHLGIGIPARQLDALERADLVLALGTQLDEVTTQSFRYPTPSQ
                     TLVLVGTGIEPARRGGLTFRVDSEVEPFLRELRNVASPRQRRASAANAAVHTFMTPPDT
                     SGATRVHPADVIRAVRKLAPEDAIVTSDAGNFAQFMHRYWCFTAPRSQLGPSNAAMGYA
                     VPAAVAAKLAEPRRTVIAMAGDGGALMTGQEIETAVRYRVPVTVLVFQNGVHGPLAVHQ
                     ARKHGRLSGVTVPITDFASWARGLGAAGYTVDDREELEPIIASALVRQRPCVIDIRTDP
                     DVVTPDIRLTSLLGAARPQQGGQ"
     misc_feature    complement(4394..4410)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            4523..5809
                     /locus_tag="NQK81_RS21040"
                     /old_locus_tag="NQK81_21040"
     CDS             4523..5809
                     /EC_number="1.1.99.24"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0047988 - hydroxyacid-oxoacid
                     transhydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330832.1"
                     /locus_tag="NQK81_RS21040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21040"
                     /product="hydroxyacid-oxoacid transhydrogenase"
                     /protein_id="WP_257489449.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.2e-102, bitscore:
                     342.5, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATAGRETVFTYGAPALKYGTGSSDEIGYDLTQYGARRVLVLT
                     DAGVAATGWPQRIAEGIETYGIEAVVFDGVHVEPTDVSMRKAVDFARGQGEWDAFVAVG
                     GGSAIDTAKAVNLLTSNDGDLLDYVNAPVGGGRAPSAPLKPLVAVPTTTGTGSESTTVC
                     VLDVLSLRVKSGISHLRMRPSLAVVDPRLTVSQPPEVTAASGMDILCHAAESYTAKPYT
                     EFDRKRPEDRVPYCGSNPLADMFAEQSLRLLSWALPAAVRDGSDMKAREAMALAATFAG
                     LGFGNAGVHIPHANAYPIAGQVRDFHPSGYPGDEAMVPHGMAVSLTAPAAFRFTFDAAP
                     DRHIRVARLLAPDYEWPGDLRDHLPAVLGQIMREIGIPNGIGAVGYTESDVDSLVSGTV
                     KQQRLLATAPREASEADLAVILRESVTLW"
     misc_feature    4547..4558
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.05"
                     /tool="antismash"
     gene            5803..6222
                     /locus_tag="NQK81_RS21045"
                     /old_locus_tag="NQK81_21045"
     CDS             5803..6222
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330831.1"
                     /locus_tag="NQK81_RS21045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21045"
                     /product="thioesterase family protein"
                     /protein_id="WP_081975695.1"
                     /sec_met_domain="4HBT_2 (E-value: 2.2e-15, bitscore: 56.2,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNAEYPHWQTVPLRWKDNDVYGHVNNVVHYSVMDTVINTWLIER
                     GGLDIETGEVIGLCVESQCKYHASVSFPGELEVGLRVGHLGRSSVRYEVGMYSKETVIA
                     EGHFVHVFVDRESRRPVPVEGLLRSALEELRTGLG"
     misc_feature    6178..6180
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6178..7914)
                     /locus_tag="NQK81_RS21050"
                     /old_locus_tag="NQK81_21050"
     CDS             complement(6178..7914)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030767.1"
                     /locus_tag="NQK81_RS21050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21050"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257489450.1"
                     /transl_table=11
                     /translation="MSVWGLYRSALAGQWRGGLVLLACSVLESAPAFLSGRLVELAVDE
                     GFAADRPGTGLRWLAIFGLVAVIGAFGSRLVWHQLGKVVEPLRDALVTAVVRGVLHDPA
                     PPRNQPDASGVARITQHVEVVRDATAGLLVQARGMIVTTVAALAGLFTVAGSLALIVAI
                     PVVVAVAVFACLLPSLARRQRALALADERTAEVAGASLSGMRDVVACGAEPLAALELYD
                     AIDTQAAAAVRVARSGAARTVVIATGGFVPLLLALLVAPGMVRDGVLTAGAALGALVYL
                     ATTMQPALRGLAATASTVVLRLIVALRRLAETAQAEPEPDGTAEPDGTAIYVRDLTFSW
                     GAAAQPVVRGLDLHLRPGERLAVVGPSGIGKSTLAGLLTGMLEPQGGRVLLGGVPVREV
                     PSALRHRMIALIPQEAYVFAGSVRDNVGLFAQTAMDRELLAAVAAVGAEPLVTRLGGLD
                     GEIGHGTLSAGEAQLIALARVYASEAGVVILDEATSHLDPPAEARAERAFAERGGVLVV
                     IAHRLSSALRADRVLVMDGKETALGTHLELMDRSTRYAQLMHAWSPRLPQPSAQFFERA
                     PE"
     gene            complement(7911..9578)
                     /locus_tag="NQK81_RS21055"
                     /old_locus_tag="NQK81_21055"
     CDS             complement(7911..9578)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633046.1"
                     /locus_tag="NQK81_RS21055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21055"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257489451.1"
                     /transl_table=11
                     /translation="MAGSADRLLVTVTLLDRPRLIGLILSALAGTAAGLLLPGALAAAV
                     DAVVAGRPSLPEVSWLIVLGVTEIAVGLIGGILTARMTASATAWLRRKLADRYLALGTR
                     STFADGDAISRLTGDCTGAGMVASVVVQLGSTTLISGGAVVLLALMDWRLALVFLGSIP
                     FGLMLARTHLRNTADDVLTYQEVSGELAARMVDAVAGLRTIAASGTADREAERVLRPLP
                     KMSLAGRGMWRTQARMVWRSGLLLPAVEIAVLAAAGFGVLDGRLTVGQVLAALGYVALG
                     MGLITQIPLLTTLSRARSCARRINEVLDSPVPEPGDLGVVPGRGTLELRGVTVEGALAD
                     VDLLVPGGRFTAVVGRSGSGKSALVNVLGGLLTPDEGAALLDGRPLERLRPNELRAVVG
                     FAFERPALLGATIGDAVGYGSWAGEAAVRAACRSAQVDDLIVRLPDGYRTPLSETPLSG
                     GEAQRIGLARAIAHAPRVLILDDATASLDTVTEAAVEEAIERTLPGRTRVVVTHRAATA
                     SRADTVVWLEDGRVRAVGAHDELWRDPAYRAVFTEGAQ"
     gene            complement(9818..9961)
                     /locus_tag="NQK81_RS21060"
                     /old_locus_tag="NQK81_21060"
     CDS             complement(9818..9961)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949109.1"
                     /locus_tag="NQK81_RS21060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21060"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_091598068.1"
                     /transl_table=11
                     /translation="MELVLDLQALETPEVLEGGGGGSHGGASNLSLLASCANSTVSLLT
                     CH"
     CDS_motif       complement(9899..9961)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MELVLDLQALETPEVLEGGGG"
                     /locus_tag="NQK81_RS21060_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9818..9898)
                     /prepeptide="core"
                     /locus_tag="NQK81_RS21060_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="11.50"
                     /molecular_weight="2356.6"
                     /monoisotopic_mass="2355.2"
                     /core_sequence="GSHGGASNLSLLASCANSTVSLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MELVLDLQALETPEVLEGGGG"
                     /leader_location="[9898:9961](-)"
                     /alternative_weights="2374.6"
                     /alternative_weights="2392.6"
                     /alternative_weights="2410.7"
                     /alternative_weights="2428.7"
                     /alternative_weights="2446.7"
                     /alternative_weights="2464.7"
     misc_feature    complement(9971..9984)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.53"
                     /tool="antismash"
     gene            complement(10001..12544)
                     /gene="lanKC"
                     /locus_tag="NQK81_RS21065"
                     /old_locus_tag="NQK81_21065"
     CDS             complement(10001..12544)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330827.1"
                     /locus_tag="NQK81_RS21065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21065"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_257489452.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1342.7,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 6.5e-11, bitscore: 41.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.5e-08, bitscore:
                     30.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRYEAYCFADPLFFDEQRETGDAADDFASLLPAPEAGWRTGVR
                     GVWRLLHPVARNLPLQGWKIHVSAGLGNAERVLVKVHEHCVEHGVSYKHLRSRSTLLAR
                     NSKYAPRDGSGKLLTLYPADNNELERVLAELSAKLDGEPGAYILSDLRYGAGPLYVRYG
                     GFAEQWVELDGKRVLAVRKPDGTLVPDKREPTFSVPDWVTIPEFLAPHLAARKSGGADQ
                     FPYQVKSSLHFSNGGGVYLADRKTDGERVVLKEARPFAGLDRDEVDAVERLRREHEVLE
                     RLKGIDGIPATYDRFTVWEHHFLAMEFMPGVSLGNWLARNYPLTRRDTTEADIAAYTER
                     ALALVRRVEAMVGEVHGRGIVFGDLHSLNILVDEDADTVSLIDFEMAADVESGKRPALG
                     APGFRAPRDRNGFEVDEYALAVLKLWIFLPLTTLLELAPAKLRGLADFVQQRFDVPEGY
                     ADSIVAELAPRDVPPLTSATELDQDKPDWALVRKQITEAILASATPERTDRLFPGDIEQ
                     FRVGGACFGYGAAGVLYALKTTSGERHREHERWLLDSIRRDPPGRPGFYDGSYGIAYVL
                     EELGYRDEATKLLSASATLVEQTTDHGLEGGLSGIGLTQLHFAVSRKDNEFGRQALATA
                     VRLAEALETAAPPGDFGRAGLLNGWSGPALLFVRLFERTREEGWLSFADQALERDIEEC
                     VESDDGSLQVRDGETRTLPYVGVGSAGILMVAEELAKHRPDAKALKSLPGLREACRGEF
                     VIHPGLLFGRGGLMTALAMGAEPDQRVRDAIDLHLSRLAWYAVPYKGGLAFPGNQLLRL
                     SMDVVTGGAGVLLALAATLDGKAALPFLSSRTAVQ"
     misc_feature    complement(12194..12196)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12854..12869
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.78"
                     /tool="antismash"
     gene            12971..13336
                     /locus_tag="NQK81_RS21070"
                     /old_locus_tag="NQK81_21070"
     CDS             12971..13336
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633043.1"
                     /locus_tag="NQK81_RS21070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21070"
                     /product="hypothetical protein"
                     /protein_id="WP_034310381.1"
                     /transl_table=11
                     /translation="MITGFAVTVAICATLVAAWSFVQAARRKLPDNALLAGLAVVELLL
                     VAQLVIGVVLLIGGGNPGSMATYLAYLIGCLVVLPLGTVWALAERTRSSTVILGIACLA
                     IPVMVLRLHEVWAGASA"
     gene            13329..13739
                     /locus_tag="NQK81_RS21075"
                     /old_locus_tag="NQK81_21075"
     CDS             13329..13739
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163353.1"
                     /locus_tag="NQK81_RS21075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21075"
                     /product="hypothetical protein"
                     /protein_id="WP_185927053.1"
                     /transl_table=11
                     /translation="MREETEEKTVDKASGPGRILVAVYAIFALAATSRAAVQISTKFHE
                     APLAYALSAFAALVYLLATVALARRGAGWWRIALVACAVELLGVLTIGTFSLFDREAFP
                     HATVWSVYGQGYLFIPLVLPVIGLYWLRRTKP"
     gene            complement(13851..14837)
                     /locus_tag="NQK81_RS21080"
                     /old_locus_tag="NQK81_21080"
     CDS             complement(13851..14837)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633041.1"
                     /locus_tag="NQK81_RS21080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21080"
                     /product="MCE family protein"
                     /protein_id="WP_257489453.1"
                     /transl_table=11
                     /translation="MRSFGAVDPIKLALAGLTTMALGMAAALNADALPVIGGGTTYSAE
                     FSDAGGLQADNDVRIAGVKVGKVSEIDLEGDRVLVSFRVKDAWVGDATSASIRIKNVLG
                     QKYLALDPHGEAVLDPGDPIPLRRTTAPYDVLEAFRDLSKTVDAIDVGQLAKSFDTISA
                     TFADTPADVRSALDGISKLSGTIASRDRQLRTLLANTRQVSRTLVDRDTEVQRLIQDGS
                     ALLRAISTRQQAIKDLLDGSKRLATALDGIIADNDGQLGPVLEQLDRLTSMLQRNQDSL
                     AKGIAAFAPAIRVLTNVAGNGRWIDGYLCGLVLPTFGPLNEKGCFDS"
     gene            complement(14944..15321)
                     /locus_tag="NQK81_RS21085"
                     /old_locus_tag="NQK81_21085"
     CDS             complement(14944..15321)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030760.1"
                     /locus_tag="NQK81_RS21085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21085"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_126732319.1"
                     /transl_table=11
                     /translation="MTTKLARFTDQKTILLKTFKRDGTPIGTPVNIAVEGDHAYIRTYD
                     AAWKAKRLRNDPRIEIAPSTFRGTPTGEPVRGRARLLEGEEARHAAALLAGKHRLLHGF
                     FVPLVHRLKKYKTLHYEVRLD"
     gene            complement(15358..15750)
                     /locus_tag="NQK81_RS21090"
                     /old_locus_tag="NQK81_21090"
     CDS             complement(15358..15750)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330823.1"
                     /locus_tag="NQK81_RS21090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21090"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_126732320.1"
                     /transl_table=11
                     /translation="MTELAIGQVTARTGLSVHALRFYEKEGLLAAPVKRDAGGRRVYTE
                     QDVDWLVNCTKFRASGMPLATIREFAGLVRQGPGNEEKRLELLREHQKTVRNRIAELAD
                     CLELISRKVEIYEEHVARGTADGLWR"
     gene            15808..16764
                     /locus_tag="NQK81_RS21095"
                     /old_locus_tag="NQK81_21095"
     CDS             15808..16764
                     /NRPS_PKS="Domain: PKS_KR (31-113). E-value: 1.4e-06.
                     Score: 20.3. Matches aSDomain:
                     nrpspksdomains_NQK81_RS21095_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030758.1"
                     /locus_tag="NQK81_RS21095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21095"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_257489454.1"
                     /transl_table=11
                     /translation="MTNAQHKIGSGFGARSTAAEVLDGIDLSGKLAVVTGGYSGLGLET
                     TRALANAGAHVVVPARRPADAEAALAGISGTEVDELDLADPASIEAFARRFLATGRPVG
                     LLIANAGIMAAPERRVGPGWESHFAICHLGHHALVSRLWPALKAAGGARVVSVSSAGHH
                     SSPMRWDDVQFERGYDRWLAYGQAKTANALFAVWLDALGAEHGIRAFSLHPGAILTPLQ
                     RHLRPEEMVERGWIDEHGNQADPDFKTPEQGAATQVWAATSPMLDGMGGLYCEDCDVAE
                     LAPEEGEWVGVRPYAIDPGEAARLWKLSGDLTGTVLA"
     aSDomain        15901..16146
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NQK81_RS21095_PKS_KR.1"
                     /evalue="1.40E-06"
                     /label="NQK81_RS21095_PKS_KR.1"
                     /locus_tag="NQK81_RS21095"
                     /protein_end="113"
                     /protein_start="31"
                     /score="20.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="AVVTGGYSGLGLETTRALANAGAHVVVPARRPADAEAALAGISGT
                     EVDELDLADPASIEAFARRFLATGRPVGLLIANAGIM"
     CDS_motif       15904..15981
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NQK81_RS21095_0001"
                     /evalue="1.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="NQK81_RS21095"
                     /protein_end="58"
                     /protein_start="32"
                     /score="21.2"
                     /tool="antismash"
                     /translation="VVTGGYSGLGLETTRALANAGAHVVV"
     gene            complement(16761..17849)
                     /locus_tag="NQK81_RS21100"
                     /old_locus_tag="NQK81_21100"
     CDS             complement(16761..17849)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330821.1"
                     /locus_tag="NQK81_RS21100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21100"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_257489455.1"
                     /transl_table=11
                     /translation="MRRLLVALAALAGMVSLASPATAAPRLTLPPPTGSYPVGSTDLHL
                     VDSSRQDPWVPSGPRELMVSMFYPAPAPIGPKRPYLTLAEAKAFLTESGLPDIDPALVA
                     GTRTSARVDAPRLPGKRALVVLSPGFGKPRTTLTGLAEELASKGFVVALIGHNYESHGT
                     AFPDGRVTECAACGSDSTLIPPIRSADVSFVLDTLTRPSSRWSHLIDRTRIGMAGHSIG
                     GYSTPTAMIDDSRIRAGADLDGRLWSPIPASGIDRPFLLLGRESEYTPAGLDTTWAGSW
                     PNLTGWKRWISVAAAGHASFTDVGVLGEQLGLGKPELLGGERGMALTRAYVSAFFDKNL
                     RGGRQPLLDGPVPGNPEIKFWN"
     misc_feature    complement(17835..17850)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.05"
                     /tool="antismash"
     gene            17990..19192
                     /locus_tag="NQK81_RS21105"
                     /old_locus_tag="NQK81_21105"
     CDS             17990..19192
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330820.1"
                     /locus_tag="NQK81_RS21105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21105"
                     /product="sensor histidine kinase"
                     /protein_id="WP_257489456.1"
                     /transl_table=11
                     /translation="MLAFLRNHPRAVDRGLTILIGLSTVVSADDPEGFEWWLVSLVALA
                     SLLVRHRNPTITFAAGGTASLLHLVMGNDLKPVDVVALIGLFSVAAWGSRRRSAGLLAA
                     GLLVAGAWSFYASEANTRTPVPMPPRIIVIDRLAPVATDADDHQVQDWGGFPAIGLSLG
                     VAWLAGLNTRQRRIRLSVLEQRAADLERERDTQAALAVAAERGRISRELHDVVAHALSV
                     VVLQAQGAQAELERRPERSREALDAIVDTGRTALSEIRRLLGALGQDEPDWEPRPGAER
                     LPRLAADIRSAGTPVEFRVEGEPRPLPSTVDLAAYRIVQEALTNVLKHAGPAASVTIVM
                     RYGPGTLEIEVTDDGVAAEPPSGTGHGLEGMRERVNVLGGTFDAGPRPERGFAVRATLP
                     S"
     gene            19189..19836
                     /locus_tag="NQK81_RS21110"
                     /old_locus_tag="NQK81_21110"
     CDS             19189..19836
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163340.1"
                     /locus_tag="NQK81_RS21110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21110"
                     /product="response regulator transcription factor"
                     /protein_id="WP_257489457.1"
                     /transl_table=11
                     /translation="MTIRVVIADDQALVRTGLRMILDNADDIDVVGEAGDGAEAVALVA
                     DLDPDVVLMDIRMPEMDGVEATAAIAAAHRTRVLVLTTFDLDEYVYAALQAGASGFLLK
                     DALAPDLLAGVRVVASGEATLAPTVTRRLLDRVVTGLPVSPPDDRLALLTGREHEVLQH
                     LARGLSNAEIAELLFLSPGTVKTHVGRILTKLGLRDRVRAVVFAYESGMISR"
     gene            complement(19826..20470)
                     /locus_tag="NQK81_RS21115"
                     /old_locus_tag="NQK81_21115"
     CDS             complement(19826..20470)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030754.1"
                     /locus_tag="NQK81_RS21115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21115"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_126732325.1"
                     /transl_table=11
                     /translation="MRPDAVSRSALEPEQVGRKVRLREVGLGDRRVLMGFDRDMAREAT
                     PLIGGGHRHWASHRSGSSGDDIHFGIETVRGRMLVGSVCTIGADPVTGRFGYGIGIAPR
                     HQRCGYATDAITVLLAHMFGQRGFRKCEVTVYGGNLASLSLHGGLGFREEGRLRDTEVV
                     RGEIKYLVRMGITAEEFAARPVDSLADLGRRGQHRRPRRGKHWRTPAAISG"
     gene            complement(20573..20776)
                     /locus_tag="NQK81_RS21120"
                     /old_locus_tag="NQK81_21120"
     CDS             complement(20573..20776)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441988.1"
                     /locus_tag="NQK81_RS21120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_21120"
                     /product="cold-shock protein"
                     /protein_id="WP_005149851.1"
                     /transl_table=11
                     /translation="MAQGSVKWFNGEKGFGFIAQDDGGPDVFVHYSEIQGSGFKSLDEG
                     QRVEFEIGQGQKGPQAQRVVAI"
     misc_feature    21248..21262
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.82"
                     /tool="antismash"
ORIGIN
        1 cgacgacgtc cccgcgctga tcgaactcgc cgcgtaccgg attctccagg aggcgctgag
       61 caacgcggca cggcacagcc ccggcgcgga agtggacgtc gaggtgcggc gaggacccga
      121 cgggctcgaa atcctcgtcg agaacgggcc gcccacgagg cctgccgcac cttcggccgg
      181 tgatggcacc ggcctcgccg ggatcgccga acgcgttacc ctgatcggcg gttcccacga
      241 ggccggaccg cgggccgacg gcggtttccg cgtggccgtc aagctggatc tcccgggggt
      301 ggacgacgcg tgacgaccgt tttcatcgtc gacgaccagg ccttggtgcg ggagagcttc
      361 gccggcctgc tgaacgcgca gccgggtctg gacgtggtgg gccaggcagg cgacgggatc
      421 gcggcgctca cggacatcgc cgcgctggcc acgccaccgg acgtcgtcct gatggacatc
      481 cggatgccgg tgatggacgg gctcgaagcg accaggcggc tgctcgaagg tgacggcgag
      541 aagccgaaag tgctcgtcct gacgacgttc catctggacg actacgtcta cgaggcgctg
      601 cgggcgggcg cgagcgggtt cctgttgaag gacgcgccgt cggccgaact gatcaacgcc
      661 atcgaagtgg tcgccgccgg tgacgcgttg ctctcccccg ccgtcacgaa gcggctcatc
      721 gcgaacttcg tggcgagcgc accggttccg cggccttccc cggcgaggtt cgacgtcctc
      781 accgaacgcg aacgggaagt actgcggttg atcgccaaag gacgctccaa tccggagatc
      841 gccgcggatc tggtgctctc ggcacagacc atcaagacgt atgtcggccg gatactggcg
      901 aaactcgggt tacgggaccg ggcacaggcg atcgtgctcg cctacgaggc tggactcgtc
      961 tcccccgcct gacggtcggc gggcctcgtc aggacgcgga cgccgagcgg gacgagcgcc
     1021 agtccgaggg ccaccgcggt gaagacgctc aggagctcgc tttccttcag cacccccatc
     1081 cagagcgtgc acggccagag gaacagcagc gcccgcacga tgccgaaggt gcccgcccgg
     1141 aacgccccga tggccagcag cagtccgccg gcgtattggc cgaccgacgc ggtgaccggg
     1201 atccgccaca gcccgtagga caggtcgacg tagtcgtcca tcaccagctt cgtcgcgtgg
     1261 tccagaccga gcttgtcgac gagctcgaag gccgtcagct cgacaccggc gaagtagacc
     1321 cgtgcgaaca aaccgaacgc gagcagcagg aatccccacg cggccaacgc cggcgccttc
     1381 gccgcgacga ttttcgccag catcaggaaa gccggcagca ggaggaccgc tccgagcagg
     1441 aagagcgagt acgcggccgt cacgaagccc gggttcgcgg cgtacgcggc gagctgtccg
     1501 ggcgcggcga agggctgctg gtcgaaccac gcgacttgct ccggcgtgaa gtccttgagc
     1561 accagatgcc gcagcaacag gcccgcgcac cacacgagcg gggcgagaat cagtgccact
     1621 ccgccgatcc atcggccggt tttcccgttc atggcgcaag cgtcgccgat ggggagggca
     1681 cggggcagcg ggcgaaggta aggcgagagc ctcgactttc gtcaggttcg ggggctgcgt
     1741 ccggcgggtc gtgagtggcg attcgggttc taacccgaat cgccactcac gaccgggccg
     1801 agcccggaaa agcagcaggg ccgcctcccc gaagggatga cggccctgct tggaaagctt
     1861 ggatcagatc acggtgaccg aggtggcctg cggacccttc gcgccctgcc cgatctcgaa
     1921 ctccacgcgg gcgttctcct cgagggtacg gaagccgttg cccttgatct cgctgtagtg
     1981 cacgaagacg tcgccgccgc cgttgtcggg agtgatgaag ccgaacccct tctcggagtt
     2041 gaaccacttc acagtgccct gagtcataaa atctccatat gcaacacaaa caaacaggaa
     2101 gccacgtcgg cagcccgggt cttgaccaga cggtttgctt ccccggaaac acgaggagac
     2161 actacgcccg ctgagttctg cgagcgtgaa ccaacacgaa cacaaaaaac gagacctgaa
     2221 tcagtaaagc acacctcacg caggccgaca agcgtcttca ccctggtgtg cgcagccgca
     2281 ctgtacctct ccggccaggg cctccgccgt ccgggctatt cgccgctcgc agcgcgcagg
     2341 ggtacctcgg tgccgaacgg cgaacggcgc aacgcctccc ggttcgtggc cacgacggcg
     2401 atgtcgtggg tctcggcgtc cgcgctgaac tgcaccggca ccacgccgga aacggacttg
     2461 tcctgtggct tcgtttcgtc agccatgttt tctcccagtg tcaacacaac gctctaagta
     2521 ctgcgtgcca acaacttcac cggtgatcgc tccggtccat atcggaccct cggtgttgcg
     2581 gcgattgtgc cacggccgac cgacaaaatc cggtctccgc gaccgaaagt cggccgagtc
     2641 gtcaccggtt tcccaccctt tggagcaggt gaaggcggcc ccacaagggt ttctgtgtat
     2701 cccctgagaa aaagttccgc ccggtcgtcc ggcgcggcgg cccctactgg ccgccttgct
     2761 gcggcctcgc ggcgcccagc aggctcgtca gccggatgtc cggggtcacc acgtccggat
     2821 ccgtcctgat gtcgatcacg cacggccgtt gccgcaccag ggcgctcgcg atgatcggct
     2881 ccagctcttc ccggtcgtcg acggtgtacc cggcggcgcc gagcccgcgt gcccacgacg
     2941 cgaagtcggt gatggggacg gtgacgcccg aaagccgtcc gtgcttgcgc gcctggtgca
     3001 cggcgagcgg gccgtgcact ccgttctgga acaccaggac ggtcaccggt acgcggtagc
     3061 ggacggcggt ctcgatctcc tgcccggtca tgagcgcgcc gccgtcgccc gccatcgcga
     3121 tcaccgtccg gcgtggttcg gcgagtttcg ccgcgaccgc cgccgggacc gcgtacccca
     3181 tggccgcgtt gctcggcccg agctggctgc gtggcgcggt gaaacaccag tagcggtgca
     3241 tgaactgggc gaagttgccc gcgtcgctgg tcacgatcgc gtcctcgggc gcgagtttgc
     3301 gcaccgcccg gatgacgtcg gcggggtgga cgcgggtggc gccgctggtg tcgggcgggg
     3361 tcatgaaggt gtgcacggcg gcgttcgcgg ccgacgcgcg ccgctgccgt ggcgaggcga
     3421 cattgcgcag ttcacgcagg aagggctcga cctcggagtc gacccggaag gtcaggccgc
     3481 cgcggcgggc gggctcgatc cccgtgccga ccagcaccag cgtctgcgac ggcgtcgggt
     3541 agcggaagga ctgcgtggtg acctcgtcga gctgtgtgcc cagcgcgagc acgaggtccg
     3601 cgcgctccag cgcgtcgagc tgccgcgcgg ggatgccgat gccgaggtgg ccggcgtagc
     3661 gcgcgtggtt ctcggggaag gcgtcctgac ggcggaacgc gttgtacacc ggcaacgcga
     3721 gctcgtcggc gacggcgatc agctcgtccc gcgcggcgcg ggcccggccg ccgacgatca
     3781 ccaccgggta gcgggcctcg tcgaccagct gcgcgaccgc ctcggcggtc cggccgagcg
     3841 cgccggtggc gggcgggcgc acggcggcca ccggtttggc cgaatcgaac gggacccccc
     3901 agaagtcggc ggggacggcg acgacggtgg gccccggccg cccttcccgg cagcgggtca
     3961 gcgcctcgac cagcaggccg ggaacctcat ccggcgattc cgcgcggccg gtccacttcg
     4021 agatcggctc gaacatcgcg gtgaggtcgg cggtcggcag ctcgctcgtc ggccccggat
     4081 cctgcggcgg gttctccagg aggacgacca tcgggctctc gtcctggtac gccgtggaga
     4141 cgccgatcgc gaggttcgcc gcgctcgggc cgcggccggc cagcagcacc gcggggtgct
     4201 cggtcagctt gccttcggcc tcggccatga aggccgcgcc ggagtcgtgt ctcgccgaga
     4261 cgaaggtgat cgaacgctcg cgttgcagcg cgtcgagcag atccaggaag gactcaccca
     4321 ccaccgcgta cacgcggtgg atctgcgcct cggtcaggat cctcacggcc gtctgggcga
     4381 cggacgctcc cggttggtat ctaatgagaa gagcttaggc gggcggtgat cggtgccgtc
     4441 aagcgatctt ccgattccgg caaccccgga gcggcggaat gtccgatatt cggaacgtgt
     4501 tcgagcaagg gagcacgaaa acgtgacctc agccaccgcc ggacgtgaaa ctgttttcac
     4561 ctacggggcg ccggccttga aatacggcac cgggtcgagc gacgagatcg gctacgacct
     4621 cacccagtac ggcgcgcgcc gcgtgctcgt cctgaccgac gcgggtgtcg ccgcgacggg
     4681 ctggccacaa cggatcgccg aaggtatcga gacctatggc atcgaagccg tcgtcttcga
     4741 cggcgtgcac gtcgagccga ccgacgtcag catgcggaag gccgtcgact tcgcccgcgg
     4801 gcagggcgag tgggacgcct tcgtcgccgt gggtggcggg tcggccatcg acaccgccaa
     4861 ggcggtgaac ctgttgacca gcaacgacgg cgacctgttg gactacgtca acgcgccggt
     4921 cggcggcggc cgcgcgccga gcgcgccgct gaaaccgctg gtcgcggtgc cgaccacgac
     4981 cgggacgggt tcggagagca ccacggtctg cgtgctggac gtgttgtcac tgcgcgtgaa
     5041 gagcggcatc agccatctcc ggatgcggcc gagcctcgcc gtggtcgacc cgcggctgac
     5101 ggtctcgcag ccgccggagg tcaccgccgc gagcgggatg gacatcctct gccacgccgc
     5161 ggagagctac acggccaagc cgtacaccga gttcgaccgg aagcgcccgg aggaccgggt
     5221 cccttactgt ggctcgaatc cgctggccga catgttcgcc gagcagtcgc tgcggctgct
     5281 gtcgtgggcg ctgcccgccg ccgtgcggga cggctccgac atgaaggcgc gcgaggcgat
     5341 ggcgctcgcg gcgacgttcg ccgggctcgg cttcggcaac gccggcgtgc acatcccgca
     5401 cgccaacgcg tatccgatcg ccgggcaggt ccgggacttc catccgtccg ggtatccggg
     5461 cgacgaagcg atggtgccgc acgggatggc cgtctcgctg acggcgcccg cggcgttccg
     5521 gttcaccttc gacgccgcgc cggaccggca catccgggtg gccaggctgc tcgcgccgga
     5581 ctacgaatgg ccgggcgacc tgcgggatca cctgcccgcg gtgctggggc agatcatgcg
     5641 ggagatcggg atccccaacg ggatcggcgc cgtcggctac accgagtccg atgtggactc
     5701 actggtttcc ggcacggtga aacaacaacg gctgctggcg acggcgccgc gcgaggcgtc
     5761 cgaagccgat ctcgccgtca tcctgcgcga gtcggtgacg ctgtggtgaa cgccgagtac
     5821 ccgcactggc agacggttcc gttgcggtgg aaggacaacg acgtctacgg gcacgtcaac
     5881 aacgtcgtcc actactcggt gatggacacc gtgatcaaca cgtggctgat cgaacgcggc
     5941 ggcctggaca tcgaaaccgg tgaggtcatc gggctgtgcg tggaatcgca gtgcaagtac
     6001 cacgcttcgg tgtcgttccc gggggaactc gaggtcggcc tgcgggtcgg ccacctcggc
     6061 cggtccagcg tccgctacga ggtcgggatg tactcgaagg agacggtgat cgcggaaggc
     6121 catttcgtgc acgtcttcgt cgatcgcgag tccaggcggc ccgtccccgt cgaaggttta
     6181 ctccggagcg cgctcgaaga actgcgcact gggctggggt agccgcggcg accacgcgtg
     6241 catgagctgg gcgtagcgcg tggaccggtc catgagttcg agatgggtgc ccagcgcggt
     6301 ctccttgccg tccatcacca ggacccggtc cgcgcgcaac gccgacgaca gccggtgcgc
     6361 gatcaccacc agcaccccgc cccgctcggc gaacgcccgt tccgcgcggg cttcggcggg
     6421 cgggtcgagg tgcgaggtcg cctcgtcgag gatgacgacg cccgcttcgc tcgcgtagac
     6481 gcgcgcgagc gcgatcagct gcgcctcgcc ggcggacagc gtgccgtgcc cgatctcgcc
     6541 gtcgagcccg cccagccgcg tgaccagcgg ttccgcgccg acggccgcca ccgccgccag
     6601 gagttcgcgg tccatcgcgg tctgcgcgaa caggccgacg ttgtcccgca ccgaccccgc
     6661 gaagacgtag gcctcctgcg ggatcagcgc gatcatccgg tgccgcagcg ccgacggcac
     6721 ctcccggacc ggcacgccgc cgagcagcac ccggccaccc tgcggttcga gcattccggt
     6781 caggagcccg gccaaggtcg acttgccgat accgctcggc cccaccaccg cgagccgctc
     6841 gccgggccgc agatgcaggt cgagcccacg caccaccggc tgcgccgccg cgccccagct
     6901 gaaggtcagg tcgcgcacgt agatcgcggt cccgtcgggt tcggccgtgc cgtcgggctc
     6961 gggctcggcc tgtgcggtct ccgcgagccg ccgcagcgcg acgatcagcc gcagcaccac
     7021 ggtgctcgcg gtcgcggcca gccctcgcaa cgccggctgc atcgtcgtcg cgaggtagac
     7081 gagcgcgccg agcgcggcgc cggcggtgag caccccgtcc ctgaccatgc ccggcgccac
     7141 cagcaacgcc aggagcagcg gcacgaaccc gccggtcgcg atcaccaccg tcctggccgc
     7201 cccggaccgc gccacccgca cggccgccgc ggcctgcgtg tcgatggcgt cgtagagctc
     7261 cagcgcggcc agcggttccg cgccgcaggc gacgacgtcg cgcatcccgg acagcgacgc
     7321 gcccgcgacc tcggcggtcc gctcgtcggc cagcgccagc gcgcgctgac ggcgagccag
     7381 cgacgggagc aggcaggcga acaccgcgac cgcgaccacc accgggatcg cgacgatcag
     7441 cgcgagcgaa ccggcgacgg tgaagagtcc ggccagcgcc gccaccgtcg tcacgatcat
     7501 cccgcgcgcc tgcaccagca gcccggccgt ggcgtcgcgg acgacttcga cgtgctgggt
     7561 gatgcgggcg acgccgctgg cgtccggctg gttccgcggc ggcgcggggt cgtgcaggac
     7621 cccgcgcacg acggccgtca ccagcgcgtc gcgcagcggc tcgacgacct tgccgagctg
     7681 atgccacacc agccgtgaac cgaacgcgcc gatcacggcg accagcccga agatcgcgag
     7741 ccaacgcagt ccggtgcctg gccgatccgc ggcaaacccc tcgtcgaccg cgagctcgac
     7801 caggcgaccg gacaagaacg cgggcgcgct ttccagtacg gagcaggcca gcaggaccag
     7861 cccgccgcgc cactgcccgg ccagcgccga gcggtagagc ccccagacgc tcattgcgcg
     7921 ccctcggtga aaaccgcccg ataagccgga tcccgccaca gctcgtcgtg cgcgccgacc
     7981 gcgcggacgc ggccgtcttc cagccacacc accgtgtccg cccgcgacgc ggtggccgcg
     8041 cgatgcgtca ccaccacccg ggtccggccg gggagcgtgc gctcgatcgc ctcttcgacc
     8101 gcggcttcgg tgaccgtgtc gaggctggcg gtggcgtcgt cgaggatgag cacccgcggc
     8161 gcgtgcgcga tcgcgcgcgc cagcccgatc cgttgcgcct ccccgccgga cagcggggtt
     8221 tccgaaagcg gcgtccggta gccgtccggc agccggacga tcaggtcgtc gacctgggcg
     8281 gaccggcagg cggcgcggac ggcggcctcg ccggcccacg agccgtagcc gacggcgtca
     8341 ccgatggtcg ccccgagcag cgcgggccgt tcgaaggcga acccgaccac cgcgcggagc
     8401 tcgttcggcc gcagccgctc cagcgggcgg ccgtcgagca gcgccgctcc ttcgtccggg
     8461 gtcagcagtc cgccgaggac gttgaccagc gcggacttcc ccgagccgga gcgcccgacg
     8521 acggcggtga accggccgcc cggcacgagc aggtcgacgt cggccaacgc gccttcgacg
     8581 gtgactccgc gcagttcgag cgtgccccgg ccggggacga ccccgaggtc gcccggttcg
     8641 gggaccggcg agtccagcac ctcgttgatt cgccgcgcgc acgaccgcgc gcgggaaagt
     8701 gtggtgagca aaggaatctg ggtgatcagg cccatgccga gcgcgacgta gccgagcgcc
     8761 gcgaggacct ggccgacggt cagcctgccg tccagcacac cgaatcctgc ggcggcgagt
     8821 accgcgattt ccaccgcggg cagcagcagc ccggagcgcc acaccatcct ggcctgtgtc
     8881 cgccacatcc cgcggccggc gaggctcatt ttcggcaggg gccgcaggac ccgttcggct
     8941 tcgcggtctg cggtgcccga cgcggcgatc gtgcggagcc cggcgacggc gtcgaccatc
     9001 ctggccgcga gttcgccgga cacctcctga taggtcagga cgtcgtccgc ggtgttcctc
     9061 agatgggtgc gcgcgagcat caggccgaac ggaatgctgc cgaggaagac gagcgcgagc
     9121 cgccagtcca tcagggcgag caggacgacc gctccgccgg agatcagagt ggtcgagccg
     9181 agctggacga cgaccgaggc gaccattccc gctccggtgc agtcaccggt gagcctgctg
     9241 atcgcgtcgc cgtcggcgaa ggtggatcgg gtgccgagtg cgagatagcg gtcggcgagt
     9301 ttccggcgca gccaagcggt ggcggacgcg gtcatccgcg cggtgaggat gccgccgatc
     9361 aggccgacgg cgatttcggt gacaccgagg acgatcagcc aggagacctc gggaaggctg
     9421 ggccgcccgg ccaccacggc gtccaccgcg gcggcgagcg cgccgggcag cagcagtccc
     9481 gccgccgtcc cggcgagcgc gctcaggatc aacccgatca ggcgggggcg atcgagcagg
     9541 gtcacggtga ccagcaggcg atcggctgaa cccgccatcc cactccttac gaactcggtt
     9601 cagtggtctt ccggcatgcg gtggcacgtc ggtcgcgtgg gtcgtgagtg gcgattcggg
     9661 ttctaacccg aatcgccact cacgacccac ccgaccggct ccgcatccca ctccttacaa
     9721 cgtgatccca acgagacgaa ccggaaggca aaataaaggc gcgggagcgg cgcacttggc
     9781 ctgtgccgct cccgcgccct cagtgttcag ccgtgactca gtggcaggtc agcaggctga
     9841 cggtgctgtt ggcgcaggag gccagcaggc tgaggttgct cgcgccgccg tggctgccac
     9901 cgccgccgcc ttcgaggacc tcgggggttt ccagagcctg caggtcgaga accagttcca
     9961 tggtgttccc tttcactagt tatctcttgg tccgctgtcc tcactggaca gcagttcggg
    10021 aggacaggaa gggcagcgcg gccttcccgt ccagggtggc ggccagtgcg agcaggacgc
    10081 ccgcgccgcc ggtgacgacg tccatcgaca gccgcagcag ctggttgccg gggaacgcca
    10141 ggccgccctt gtacggcacc gcgtaccagg cgagccgcga aagatgcagg tcgatggcgt
    10201 cgcggacccg ctggtccggt tcggcgccca tggccagcgc ggtcatcagc ccgccgcggc
    10261 cgaacagcag accagggtgg atgacgaact cgccgcggca cgcctcacgc aggccgggaa
    10321 ggctcttcaa cgccttcgcg tcgggacggt gtttcgccag ctcctcggcg accatgagga
    10381 tccctgcgct gccgacaccc acgtagggca acgtccgggt ctcgccgtcg cggacctgca
    10441 gcgagccgtc gtcggactcg acgcactcct cgatgtcccg ctccagcgcc tgatccgcga
    10501 aggacagcca gccctcttcg cgggtgcgct cgaacagccg cacgaacagc agcgccggac
    10561 cggaccagcc gttgagcagc ccggccctgc cgaagtctcc gggcggggcg gcggtttcga
    10621 gcgcttcggc cagccggacg gcggtggcga gcgcctgcct gccgaactcg ttgtccttgc
    10681 gggacaccgc gaagtgcagc tgggtgagcc cgatcccgga caggccgcct tccaggccgt
    10741 ggtcggtggt ctgctcgacc agcgtcgccg acgccgacag cagcttggtg gcctcgtccc
    10801 ggtacccgag ttcttcgagg acgtacgcga tcccgtacga gccgtcgtag aaccccgggc
    10861 ggcccggggg gtcgcggcgg atcgagtcca gcagccagcg ctcgtgctcc cggtgacgct
    10921 cgccgctggt cgttttcagt gcgtagagga cgccggccgc gccgtagccg aagcacgctc
    10981 cgccgacgcg gaactgctcg atgtcgccgg ggaagagccg gtcggtgcgc tcgggggtcg
    11041 cgctggcgag gatcgcttcg gtgatctgct tgcgcaccag cgcccagtcg ggcttgtcct
    11101 ggtccagctc ggtcgcgctc gtcagcggcg gcacatcccg gggcgcgagc tcggcgacga
    11161 tcgagtcggc gtaaccctcc gggacgtcga aacgctgctg gacgaagtcc gcgagcccgc
    11221 gcagcttcgc cggggcgagt tcgaggagcg tggtgagcgg caggaagatc cagagtttca
    11281 ggacggcgag cgcgtactcg tcgacctcga agccgttccg gtcccgtggg gcgcggaaac
    11341 cgggcgcgcc gagggcgggc cgtttgccgc tttcgacgtc ggccgccatc tcgaagtcga
    11401 tcagcgagac cgtgtcggcg tcttcgtcga ccaggatgtt cagcgagtgc aggtcgccga
    11461 agacgatccc ccggccgtgc acctcgccga ccatcgcctc cacccgccgg accagcgcca
    11521 gcgcgcgttc ggtgtacgcg gcgatgtcgg cctcggtggt gtcgcgcctg gtgagcgggt
    11581 agttgcgggc gagccagttg cccagcgaga cgccgggcat gaactccatc gccaggaagt
    11641 ggtgctccca gacggtgaag cggtcgtagg tggcgggaat gccgtcgatg cccttcaacc
    11701 gctccagcac ctcgtgctca cggcggaggc gttcgacggc gtcgacctcg tcgcgatcca
    11761 ggccggcgaa cggccgcgcc tccttgagga ccacccgttc gccgtcggtc ttccggtcgg
    11821 cgaggtacac gccgccgccg ttggagaagt gcagcgagct cttcacctga taggggaact
    11881 gatccgcgcc gccgctcttg cgagcggcga gatgaggcgc gaggaactcc ggaatcgtca
    11941 cccagtcggg gacggagaag gtcggctcgc gtttgtccgg gaccagcgtc ccgtccggtt
    12001 tgcgcaccgc gaggacccgc ttgccgtcga gttcgaccca ttgctcggcg aatccgccgt
    12061 agcggacgta gagcggcccg gcaccatacc gaagatcact gagaatgtat gcccccggct
    12121 cgccgtcgag cttcgccgac aactcggcga gaacgcgctc gagctcgttg ttgtcagccg
    12181 gataaagagt cagtaactta ccgcttccgt cacgcggggc atatttcgaa ttccttgcca
    12241 gcagggtgct ccgcgagcgg agatgcttgt aggacacgcc gtgctcgaca caatgctcgt
    12301 gcaccttcac gagcacccgc tcggcgttgc ccaaacctgc cgaaacgtgg attttccagc
    12361 cctgcaaggg aaggtttcga gcaacagggt gcaacagccg ccacactccg cgcactccgg
    12421 tgcgccagcc cgcctcgggt gccggcagca gggaggcgaa atcgtcggcg gcgtccccgg
    12481 tttcccgctg ctcatcgaag aacagtggat cggcgaagca atacgcttcg taccggacgt
    12541 ccatcgagcg ccccctcctt ggcaccaatc ggatgggcca tgtgcaccat cgcgatggag
    12601 aatattccac ccgccggaca ccgaacggcc aatccgccat atcgggggtt cggatgggct
    12661 gttcagggac gtgaattcga aatctaccga atggtagggg tacccagcgt gagatcaact
    12721 cgtatttcaa ccacccggtc ggtgtgtaac aggaacgaac cggcgaggta atccctggtc
    12781 caggtggcca acacaaaatc gctcgaccga attgacagag cgccaaccga acgcgcttcg
    12841 tgatctattc acccgaggtc tggaccagtg cgccggtgcg tggcgcccgc cacgcaccct
    12901 gccggtcgcc cgtcggcggt gatccgcccg gaggtacgtt gtcgccggtg gagcaggtaa
    12961 ggaggccgac gtgatcacag gcttcgcggt gaccgtcgcg atctgcgcga cgctggtcgc
    13021 ggcgtggagt ttcgtccagg ccgcgcgcag gaaattgccg gacaacgcac tgctcgccgg
    13081 cctcgccgtg gtcgaactcc tgctggtggc ccagctcgtg atcggggtcg tgctgctgat
    13141 cggcggcggc aatcccggca gcatggccac ctatctcgcc tacctgatcg gctgtctcgt
    13201 cgtgctcccg ctcgggacgg tctgggcgct ggccgagcgc acccggtcga gcaccgtgat
    13261 cctcggcatc gcctgtctcg cgatcccggt gatggtcctg cggctgcacg aggtctgggc
    13321 gggcgccagt gcgtgaggaa accgaggaga agacggtgga caaggcttcc ggcccgggac
    13381 ggatcctggt cgccgtgtac gcgatcttcg cgctggcggc gacctcacgc gccgccgtgc
    13441 agatcagcac caaattccac gaagcgccgc tggcctacgc cctctccgcg ttcgcggccc
    13501 tcgtctatct cctggccacc gtcgcgctgg cccgccgcgg cgcgggctgg tggcggatcg
    13561 cgctggtcgc ctgcgccgtc gaactgctcg gcgtgctgac catcggcacc ttcagcctct
    13621 tcgaccgcga ggccttcccg cacgccaccg tgtggtcggt ctacggccag ggatacctct
    13681 tcatcccact ggtgctgccg gtgatcgggt tgtactggtt gcggcggacg aagccctgac
    13741 acgcaactcg cgtgatcaga ggcgtatctc gcgtgattga aggcgtaact cgtgtgttcc
    13801 gcctctgatc acgcgagtta cggctccaat cacgcgagat acgccttcca tcacgagtcg
    13861 aaacagccct tttcgttgag cggaccgaac gtgggcagca ccagcccaca caggtagccg
    13921 tcgatccagc gcccgttgcc cgcgacgttg gtgagcaccc ggatcgccgg cgcgaacgcg
    13981 gcgatcccct tggccagcga atcctgattg cgctggagca tcgacgtcag ccggtcgagt
    14041 tgttcgagca ccggcccgag ctggccgtcg ttgtcggcga tgatgccgtc gagcgcggtc
    14101 gcgagccgtt tagatccgtc gagcagatcc ttgatcgcct gctgccgggt ggagatcgcg
    14161 cgcagcagcg cgctgccgtc ctggatcagc cgctggacct cggtgtcgcg gtcgacgagg
    14221 gtccgcgaca cctgccgggt gttcgcgagc agcgtccgga gctgccggtc gcgggaggcg
    14281 atggtgccgg acagtttcga gatcccgtcc agcgccgagc ggacgtcggc gggcgtatcg
    14341 gcgaaggtcg ccgaaatcgt gtcgaagctt ttcgcgagct ggccgacatc gatggcgtcg
    14401 acggttttcg acaaatcccg aaacgcttca agaacgtcat acggcgcggt ggtccgccgc
    14461 agcggaatgg gatctccggg atcgaggacc gcttcgccgt gcggatcgag cgccaaatac
    14521 ttctgcccca gcacgttctt gatccgaatg gacgcgctcg tggcgtcgcc gacccaggcg
    14581 tccttcaccc ggaacgacac gagcacgcgg tcgccttcga ggtcgatctc ggacactttg
    14641 ccgaccttca ccccggcgat ccggacgtcg ttgtccgcct gcagcccgcc cgcgtcggag
    14701 aattcggcgg aataggtggt gccgcccccg atgaccggca gcgcgtcggc gttgagcgcc
    14761 gccgccatcc cgagcgccat ggtggtgagc ccggcgagcg cgagcttgat cggatccacc
    14821 gcaccgaagg acctcatcgt ctcacctcgc aggtcacaag cggaaaagct taagggccgc
    14881 tcacgcccat cgccaggcga aacgttgcac cgatcgggtg gcaacgtctg tccattatgg
    14941 actctaatcg agccgtacct cgtaatggag cgtcttgtac ttcttcagcc ggtgcacgag
    15001 cgggacgaag aacccgtgca ggagccgatg cttcccggcc aggagggcgg ccgcgtgccg
    15061 ggcctcttca ccttcgagca gacgggcccg cccgcgcacc ggctccccgg tcggagtgcc
    15121 gcgaaacgtc gacggggcga tctcgatccg cggatcgttc cgcaagcgct tggccttcca
    15181 cgccgcgtca tacgtacgga tgtacgcgtg atccccttcg acggcgatgt tgaccggcgt
    15241 cccgatgggc gtgccgtccc gcttgaaagt cttcagcagg atcgtcttct ggtccgtgaa
    15301 cctggcgagt ttcgtggtca tgtccctgtg acgagaccgc cgcgcgaaac gtgacggcta
    15361 gcgccagagc ccgtccgccg tcccccgcgc gacatgctcc tcgtagatct cgaccttccg
    15421 gctgatcagc tccaggcaat cggccagttc ggcgatccga ttccggacgg tcttctgatg
    15481 ttcccgcagc agctccagcc gcttttcctc gtttcccggc ccttgccgga cgagtccggc
    15541 gaattcgcgg atggtggcga gcggcatccc ggacgcccgg aacttcgtgc agttcaccag
    15601 ccaatccacg tcctgctcgg tgtacacgcg gcggccgccc gcgtcccgtt tcaccggcgc
    15661 cgcgagcagc ccttccttct catagaagcg aagcgcgtgc acgctgaggc ccgtccgggc
    15721 ggtgacctgg ccgatcgcga gttccgtcac cgcaccgacg atagcgccct tgacctagag
    15781 cgccctctag ctcctagcgt ccgcctcatg accaacgcac aacacaagat cggctccggt
    15841 ttcggcgcgc gcagcaccgc cgccgaggta ctggacggga tcgacctctc cggcaagctc
    15901 gccgtcgtca ccggcggcta ttcggggctg ggcctggaaa ccacgcgcgc gctggcgaac
    15961 gcgggcgcgc acgtggtcgt ccccgcgcgc cgcccggccg acgccgaggc cgccctcgcc
    16021 gggatctccg gtaccgaggt cgacgagctc gacctcgccg atccggcgag catcgaggcc
    16081 ttcgcccggc ggttcctcgc caccggccgc ccggtcggcc tgctgatcgc gaacgccggg
    16141 atcatggccg cgccggaacg acgggtgggc cccggctggg agtcgcattt cgcgatctgc
    16201 cacctcggcc accacgccct ggtgagccgg ctctggcccg cgctgaaggc ggccggtggt
    16261 gcccgcgtcg tctcggtgtc ctccgccggt caccattcct cgccgatgcg ctgggacgac
    16321 gtccagttcg agcgcggcta cgaccgctgg ctcgcgtacg gccaggccaa gaccgccaac
    16381 gcgctgttcg cggtgtggct ggacgcgctc ggcgccgaac acgggatccg cgcgttcagc
    16441 ctgcatccgg gcgcgatcct cactcccctg cagcggcatc tgcggccgga ggagatggtc
    16501 gaacgcggct ggatcgacga gcacgggaac caggccgacc cggacttcaa aacgccggag
    16561 cagggcgcgg ccacccaggt ctgggcggcg acgtcaccga tgctcgacgg gatgggcggg
    16621 ctctactgcg aggattgcga cgtcgccgag ctcgcccccg aagagggcga gtgggtcggc
    16681 gtgcgcccgt acgcgatcga tcccggcgag gccgcgcggc tctggaagct ctccggcgac
    16741 ctcaccggga ccgtcctcgc ctagttccag aacttgatct cggggttacc cggcaccggc
    16801 ccgtccagca gcggctgacg cccgccgcgc aggttcttgt cgaagaacgc ggacacatac
    16861 gccctggtca gcgccattcc tcgctcgccg ccgagcagct cgggtttgcc gagcccgagc
    16921 tgttcaccga ggacaccgac gtcggtgaag gacgcgtgcc cggccgccgc gacgctgatc
    16981 cagcgcttcc agccggtgag gttcggccag ctgcccgccc acgtcgtgtc caggccggcc
    17041 ggggtgtact cgctttcgcg gccgagcagc aggaacggcc ggtcgatccc ggacgcgggg
    17101 atcggcgacc acagcctgcc gtccaggtcg gcgcccgcgc ggatccgcga gtcgtcgatc
    17161 atcgcggtcg gcgtgctgta tccgccgatg gaatgccccg ccatcccgat acgcgtccgg
    17221 tcgatcaggt gggaccagcg cgacgaaggc ctggtcagcg tgtcgaggac gaacgagacg
    17281 tccgcggaac ggatcggcgg aatgagtgtc gagtcggatc cgcacgcggc gcattcggtg
    17341 acgcgtccgt cggggaaggc ggtgccgtgg gactcgtagt tgtggccgat cagcgcgacg
    17401 acgaacccct tgctcgccag ctcttccgcg agcccggtga gcgtcgtgcg cggtttgccg
    17461 aatcccggcg acaggacgac gagcgcgcgc ttccccggca ggcgcggggc gtcgaccctg
    17521 gcgctggtgc gggttccggc gaccagtgcg gggtcgatgt cgggaaggcc cgattcggtc
    17581 aggaacgcct tggcctcggc caaggtgagg tagggccgtt tcgggccgat cggcgccggc
    17641 gcggggtaga acatcgacac catcagctcg cgcggcccgg acggcaccca cgggtcctga
    17701 cgcgagctgt cgacgaggtg gaggtcggtg gagccgacgg gatacgagcc ggtcggcggc
    17761 ggcagcgtca ggcgcggggc cgcggtggcg gggctcgcca acgacaccat gccggcgagg
    17821 gcggccagcg cgacgagaag ccttctcatg aggtttccgt ttctgtcgag gatcttcctg
    17881 cgaccaggct ggagcccgcc gccgtgttcg cgcgtctgcc gcaggtcgta tccctgggtc
    17941 tgccgcgaga gggattcgcg ccgcccgctc ctccgattac gctcggctgg tgctggcctt
    18001 cctcaggaat cacccgagag ccgtcgaccg cggcctgacc atcctcatcg gactgtccac
    18061 tgtggtctcg gcggacgatc cggagggctt cgagtggtgg ctggtctcgt tggtggcctt
    18121 ggcttccctg ctcgtccggc accggaatcc cacgatcacc ttcgcggccg gggggacggc
    18181 ctcactcctg catctggtca tgggcaacga cctcaaaccg gtcgacgtcg tggcgctgat
    18241 cggtctcttc tccgtcgcgg cctgggggtc gcgacggcgt tccgccggtt tgctggccgc
    18301 ggggttgctc gtcgccgggg cgtggtcgtt ctatgcatcg gaagcgaaca cgcggacccc
    18361 cgtcccgatg ccgccgcgga tcatcgtcat cgatcggctg gccccggtcg ccaccgacgc
    18421 cgacgaccac caggtgcagg actggggcgg ttttccggcc atcggcctgt cgctcggcgt
    18481 ggcgtggctc gccgggctga acacgcggca gcgccggatc cgcctgtcgg tgctggagca
    18541 gcgggccgcc gacctcgaac gcgaacgcga cacccaggcc gcgctggccg tggccgccga
    18601 acgcggccgc atcagccgcg aactgcacga cgtcgtcgcg cacgcccttt ccgtggtggt
    18661 cttgcaggca cagggcgcgc aagcggagct ggaacggcga cccgaacggt cacgggaggc
    18721 gctggacgcc atcgtcgaca cggggcgcac cgcattgagc gagatccggc ggctgctcgg
    18781 cgcgctcggc caggacgagc cggactggga gccccggccc ggtgcggaac gcctgccgcg
    18841 gctggccgcc gacatccggt cggcgggcac gccggtcgag ttccgcgtcg aaggggaacc
    18901 ccggcccctt ccgtccacag tggaccttgc ggcctaccgg atcgtgcagg aagcgctgac
    18961 gaacgtgctg aaacacgccg gtccggccgc gtcggtgact atcgtgatgc gctatggccc
    19021 cggcacgctg gagatcgagg tgaccgacga cggcgtcgcg gccgaaccac cgtccggcac
    19081 cgggcacggc ctcgaaggga tgcgggaacg ggtgaacgta ctgggcggca ccttcgacgc
    19141 gggaccgcgg ccggagcgcg gcttcgccgt ccgcgcgacc ctgccgtcat gacgatccgg
    19201 gtggtcatcg ccgacgacca ggcgctcgtg cgcaccggac tgcggatgat cctggacaac
    19261 gcggacgaca tcgacgtcgt cggcgaggcg ggcgacggcg cggaggccgt cgcgctggtg
    19321 gcggacctcg atcccgacgt cgtgctcatg gacatccgga tgcccgagat ggacggcgtc
    19381 gaggccaccg ccgcgatcgc cgcggcccat cgcacccgcg tcctggtgct gaccacgttc
    19441 gacctggacg aatacgtcta cgccgcgctc caggcggggg ccagcggctt cctgctcaag
    19501 gacgcgctgg cgccggatct gctcgccggt gtccgtgtgg tcgcctccgg cgaggcgacc
    19561 ctcgcgccga ccgtcacccg gcggctgctc gaccgcgtcg tcaccggcct gcccgtgtcg
    19621 ccgccggacg accggctcgc cctgctcacc ggccgcgaac acgaggtgct ccagcacctg
    19681 gcccgcggcc tgtccaacgc cgagatcgcc gagctgctgt tcctctcgcc cgggacggtg
    19741 aagacccacg tcggccgcat cctcacgaaa ctcggcctcc gcgaccgcgt ccgggcggtc
    19801 gtcttcgcct acgaatccgg gatgatcagc cgctgatcgc ggcgggcgtg cgccagtgct
    19861 tgccgcgccg gggccgccgg tgctggccac gcctgccgag gtcggcgagg ctgtccacgg
    19921 gacgcgcggc gaactcttcg gcggtgatgc ccatccgcac gaggtacttg atctcgccgc
    19981 gcaccacctc ggtgtcgcgc agcctgcctt cctcgcggaa gccgagaccg ccgtgcagcg
    20041 acagcgacgc caggttgccg ccgtacacgg tgacctcgca tttgcggaag ccgcgctgcc
    20101 cgaacatgtg ggccaggagg acggtgatgg cgtccgtggc gtatccgcag cgctggtggc
    20161 ggggggcgat cccgatgccg tagccgaacc ggccggtcac cgggtcggcg ccgatggtgc
    20221 agaccgagcc gaccagcatc cggccgcgca ccgtctcgat gccgaagtgg atgtcgtcgc
    20281 cggaggatcc cgaacggtgt gaggcccagt ggcggtgccc gccgccgatc agcggcgtcg
    20341 cctcgcgggc catgtcacgg tcgaagccca tcaggacccg gcgatccccc agcccgacct
    20401 cgcgcaaccg caccttccgc ccgacctgct ccggctccag ggcggagcgg ctcaccgcgt
    20461 ccggccgcac gggtgctcac gaacgatcac aagcatgcaa cgacgatatc gggtcccgaa
    20521 acgcccgaag gcccccaccc ggtccggatg gaggccttcg gcgtgaagaa agtcagatgg
    20581 cgacgacgcg ctgggcctgc gggcccttct gaccttggcc gatctcgaac tcgacgcgct
    20641 gcccttcgtc cagggacttg aaaccgctgc cctggatctc cgagtagtgc acgaaaacgt
    20701 ccggtccgcc gtcgtcctga gcgatgaagc cgaagccctt ttcgccgttg aaccacttaa
    20761 cgctgccctg agccatactt tttctacctg ctcttcatag cgagtctgag ctcattcgat
    20821 gccccgatct cgtggaccat tctcgcaggt cttgcccggt aacacacgtc gccgtctcaa
    20881 attcgtgcag atcgccaggt caaggtcacc ctcggcgggt caccaggagg gggttgaccg
    20941 ccgatttccg gcccgggatg tcccgaatgt gaccttgggg acgttgagcg tcccgatcga
    21001 gcgatcggcg tggtgttccc gccgcgtcag tggccgtccg gctcggaccc gatccggtag
    21061 ggcaccggct tgccgtcctc gtcgcacacc tcgaccggct tgccctcggc gtccacgatc
    21121 ttgccgtcga cgatccggtc gccgtccttg agccgcgaga aggccttgag atcggagtag
    21181 tcgatcaccc tggtcgcggt cgcgaacacc gacgggtcgc tgcccgcctt ggccggtttc
    21241 aggtggttga acagcaggtt cagcacgacg gccatgagcg cggccgagct gatccccgag
    21301 tggaagatcg tgccgaccca cgccgggaag tggtggtaga actccggcgc cgcgatcggg
    21361 accatcccca gcccgaccga cgcggcgacg atcaccaggt tcatgttccc gttgtagtcc
    21421 actttggaca gggtcttgat accggacgcc gccaccgtgc cgaacagcac gagcccggcg
    21481 ccgcccagca ccgggtacgg gatcgcggcg acgacccggc cgagtaccgg gagcatgccc
    21541 agtaccagca ggatcacgcc gccggcggtc accacgaacc ggctccggac cccggtgatc
    21601 gcgaccagcc cgacgttctg ggcgaacgcg ctctgcatga acccgttgaa gaccggcgcg
    21661 accgccgagg aggccatgtc ggcgcgcagc ccgtcgccga tccggcgttt gccgaccttc
    21721 gtcccgacga tctcccccac cgcgagcatg tcggccgtgg tctcggtgag ggtcaccagc
    21781 acgacgatga acatcgacac gatcgcggcg acgtcgaagg tcggcgcgcc gaaaccgaac
    21841 ggggtcggta ccgcgaagat cgggccgtcc cagacccgcg agaagtcggc cttgcccagc
    21901 acggcggcca gtacggtgcc gaccacgatc gacaggagga tcgagagccg ggagatggcc
    21961 gggacggcga ccttgctgag cagcagcacg atcgccagcg tcatggcggc aaggccgatg
    22021 ttggagaccg agccgaactc cggcgacttg gtgttgttgc ccatcgccca ctgggccgcg
    22081 accggcatca ggctgagccc gatcacggtg atcaccgtcc cggtgaccac cggcgggaag
    22141 tacttcacca gccgggagaa caccggcgtg atgagcaggc cgagcaccgc ggacgcgatc
    22201 accgagccga acacggcggg caagccgccg tcggccacga tcgcggtcat cgtcgccacg
    22261 cccgcgaagg aggtgccctg gaccagcggc agccgggagc cgaagaaggg gatgccgaac
    22321 gactgcagga tcgtcgccag accgccgatg aacaggcacg acgcgaccag cagcccgatc
    22381 tcggcggtcg agacgcccgc ggcgccgccg atgatcaggg gcggcgcgat gatcccgccg
    22441 tacatcgtca ggacgtgctg gatgccgtaa gtgaaactct tgccgatccc gagccgttcg
    22501 tcctcgggcc tgccgctcgc ggccgcttcg gcccgcgtcc tctt
//
