LOCUS       NZ_CP102415            21131 bp    DNA     circular CON 26-AUG-2024
DEFINITION  Amycolatopsis roodepoortensis strain ZEL-1 chromosome, complete
            genome.
ACCESSION   NZ_CP102415
VERSION     NZ_CP102415.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis roodepoortensis
  ORGANISM  Amycolatopsis roodepoortensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Biodegradation of petroleum hydrocarbons by Amycolatopsis orientalis
            ZEL-1, genome analysis and its potential in plant protection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2022) College of Life Sciences, Sichuan Normal
            University, No. 1819, Section 2, Chenglong Avenue, Longquan
            District, Chengdu 610101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024628825.1-RS_2024_08_26
            Annotation Date                   :: 08/26/2024 06:13:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,064
            CDSs (total)                      :: 8,994
            Genes (coding)                    :: 8,928
            CDSs (with protein)               :: 8,928
            Genes (RNA)                       :: 70
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 27 of 66
            Pseudo Genes (incomplete)         :: 44 of 66
            Pseudo Genes (internal stop)      :: 4 of 66
            Pseudo Genes (multiple problems)  :: 9 of 66
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:48:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 113369
            Orig. end                         :: 134500
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102415.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21131
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21131
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21131
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11131](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11131
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    78..98
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            288..509
                     /locus_tag="NQK81_RS00480"
                     /old_locus_tag="NQK81_00480"
     CDS             288..509
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_00480"
                     /product="hypothetical protein"
                     /protein_id="WP_257486505.1"
                     /transl_table=11
                     /translation="MTAGPDVLPVTPGRGSMLWAGRAQHPRKWFPEYTVMIIAIGMAAV
                     LIVFGHPGSALPFYAGMLLAFGVFSSSA"
     gene            506..721
                     /locus_tag="NQK81_RS00485"
                     /old_locus_tag="NQK81_00485"
     CDS             506..721
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_00485"
                     /product="hypothetical protein"
                     /protein_id="WP_257486506.1"
                     /transl_table=11
                     /translation="MNDRRARDRALSYLVTTQRIIVAASRPNGTEFRRVWLRYVQHPPK
                     VKAGKAGGGTITFGGVRGRRQLRSWN"
     gene            807..1292
                     /gene="rraA"
                     /locus_tag="NQK81_RS00490"
                     /old_locus_tag="NQK81_00490"
     CDS             807..1292
                     /GO_function="GO:0008428 - ribonuclease inhibitor activity
                     [Evidence IEA]"
                     /GO_process="GO:0051252 - regulation of RNA metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rraA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032734.1"
                     /locus_tag="NQK81_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00490"
                     /product="ribonuclease E activity regulator RraA"
                     /protein_id="WP_257486507.1"
                     /transl_table=11
                     /translation="MIDSFTTADLVDEHGDRLRVCDTQFRQFGGHRKFSGPIRTVSCHE
                     DNGLVKKLLATPGDGAVLVVDGGGSLHSALTGDMIAKSAVDNGWAGIVVNGAVRDSAEL
                     AGLPLGVKALGTNPRKSSKAGVGAVDVPVGFGGVTFTPGDTLYADDDGVVILPPAGS"
     gene            complement(1299..2192)
                     /locus_tag="NQK81_RS00495"
                     /old_locus_tag="NQK81_00495"
     CDS             complement(1299..2192)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-182). E-value: 4e-33. Score:
                     106.8. Matches aSDomain:
                     nrpspksdomains_NQK81_RS00495_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_158889528.1"
                     /locus_tag="NQK81_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00495"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_257486508.1"
                     /sec_met_domain="ADH_N (E-value: 2.6e-07, bitscore: 29.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.5e-09, bitscore:
                     35.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVIFTEFGGPEVLQLVDAEDPHAGPGQVRIAVRAAGVNPVDWR
                     IREGQVLGAHPTVLPSGVGLDAAGIVDEVGEGVVGVDVGDFVFGEGASTYAEFAVLTAW
                     AVMPDGLTFEEAAGYPSVVETALRLIREVGARPGEKLLVSGASGGVGSAVLQIARERGI
                     EVIGTAGAANQDYLRGLGALATTYGEGWVERVRRFGRVDAALDLAGSGVIAELVELTGD
                     PGKVVSIADLGAPEFGVRFSGVAGSVPDALAEAVDLIARGKLHIPVEKAYPLADAAAAH
                     ADSRAGHTRGRRVIVV"
     CDS_motif       complement(1461..1484)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NQK81_RS00495_0003"
                     /evalue="6.90E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="NQK81_RS00495"
                     /protein_end="244"
                     /protein_start="236"
                     /score="-2.5"
                     /tool="antismash"
                     /translation="FGVRFSGV"
     aSDomain        complement(1647..2150)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NQK81_RS00495_PKS_ER.1"
                     /evalue="4.00E-33"
                     /label="NQK81_RS00495_PKS_ER.1"
                     /locus_tag="NQK81_RS00495"
                     /protein_end="182"
                     /protein_start="14"
                     /score="106.8"
                     /tool="antismash"
                     /translation="LQLVDAEDPHAGPGQVRIAVRAAGVNPVDWRIREGQVLGAHPTVL
                     PSGVGLDAAGIVDEVGEGVVGVDVGDFVFGEGASTYAEFAVLTAWAVMPDGLTFEEAAG
                     YPSVVETALRLIREVGARPGEKLLVSGASGGVGSAVLQIARERGIEVIGTAGAANQDYL
                     RGLGA"
     CDS_motif       complement(1719..1781)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NQK81_RS00495_0002"
                     /evalue="2.60E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="NQK81_RS00495"
                     /protein_end="158"
                     /protein_start="137"
                     /score="16.8"
                     /tool="antismash"
                     /translation="GEKLLVSGASGGVGSAVLQIA"
     CDS_motif       complement(1968..2003)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NQK81_RS00495_0001"
                     /evalue="2.20E-02"
                     /label="PKSI-ER_m2"
                     /locus_tag="NQK81_RS00495"
                     /protein_end="75"
                     /protein_start="63"
                     /score="8.0"
                     /tool="antismash"
                     /translation="GLDAAGIVDEVG"
     misc_feature    2174..2188
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            2263..2841
                     /locus_tag="NQK81_RS00500"
                     /old_locus_tag="NQK81_00500"
     CDS             2263..2841
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075679.1"
                     /locus_tag="NQK81_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00500"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_257486509.1"
                     /transl_table=11
                     /translation="MTVPTGRRERKKAATRQKIAETALRLFLERGYDAVGIREVAAEAD
                     VAVTTLFSHFASKEALVFEQDANFEQGLARAVTGRAPHEPLIPALRHEVHAMVRHCTAD
                     GAAPIWRMIDESPALREYEDSMRLRHAETLAAAIAADPESARSATACRTIARFVLDAYS
                     LGREAADPEVAVNEIFRMIEAAWEATGPA"
     misc_feature    2845..2857
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
     gene            2916..3755
                     /locus_tag="NQK81_RS00505"
                     /old_locus_tag="NQK81_00505"
     CDS             2916..3755
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020636769.1"
                     /locus_tag="NQK81_RS00505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00505"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_257486510.1"
                     /transl_table=11
                     /translation="MLTQVAEGVLVHQSALLENNAVVVEGADGVLLVDPGLTGAEMACL
                     AHDLADSGRPVVAGFATHPDWDHVLWHPELGDAPRYGTARCAEYLRDLRSNPDWKTGVA
                     EGLPPEISGEVPLDLFGLITGLPAGTTRIPWDGPRIRIVEHPAHAPGHAALVIEERGVL
                     VAGDMLSDVLVPMFDDDGDPLEDYLAGLRVIEDVAGDAAVVVPGHGAVGGAGAVRARID
                     LDRAYVHALRDGRTPDDPRIGSSAKPGWEWVRDLHDGQAQSLARRQASASRHDAELP"
     gene            complement(3723..4169)
                     /locus_tag="NQK81_RS00510"
                     /old_locus_tag="NQK81_00510"
     CDS             complement(3723..4169)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS00510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_00510"
                     /product="hypothetical protein"
                     /protein_id="WP_257486511.1"
                     /transl_table=11
                     /translation="MTYPQQQSPIWQQYPVAPPKKAPKTGLIVGIAAAAVVVTGGALAV
                     TVAITTSGGSSGADVPQVDPDPFSAQAGDCISADEDAGSNGAFSASAVRVHCSDSSANY
                     SVIAQLASASGSDCNTVPGYEYGNPVVYDFKSGESRELCVMPRG"
     gene            complement(4213..4824)
                     /locus_tag="NQK81_RS00515"
                     /old_locus_tag="NQK81_00515"
     CDS             complement(4213..4824)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (44-149). E-value: 1.7e-15. Score:
                     47.9. Matches aSDomain: nrpspksdomains_NQK81_RS00515_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032728.1"
                     /locus_tag="NQK81_RS00515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00515"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_257486512.1"
                     /transl_table=11
                     /translation="MTRPARWNRYWDTKSRNYDREMQFLDRKLFGDSRAWACGQADGEV
                     LEVAVGTGLNLPLYAEGVTLTGIDLSDGMLSIARARAERLGRPVTLRRADAHHLPFDAD
                     SFDTVVCTLGLCAIPDDGKALREMARVLRPGGRLILLDHIASSSRAVRGLQWMAEKITV
                     PMAGEHFLRRPLEKIDGLGLAVEHRERFKLGLVERLVARK"
     aSDomain        complement(4378..4692)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NQK81_RS00515_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.70E-15"
                     /label="NQK81_RS00515_oMT.1"
                     /locus_tag="NQK81_RS00515"
                     /protein_end="149"
                     /protein_start="44"
                     /score="47.9"
                     /tool="antismash"
                     /translation="VLEVAVGTGLNLPLYAEGVTLTGIDLSDGMLSIARARAERLGRPV
                     TLRRADAHHLPFDADSFDTVVCTLGLCAIPDDGKALREMARVLRPGGRLILLDHIASSS
                     R"
     gene            complement(4835..5488)
                     /locus_tag="NQK81_RS00520"
                     /old_locus_tag="NQK81_00520"
     CDS             complement(4835..5488)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032727.1"
                     /locus_tag="NQK81_RS00520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00520"
                     /product="cation transporter"
                     /protein_id="WP_257486513.1"
                     /transl_table=11
                     /translation="MSVESDSCADGCCTAKSTVAPERRAVLSQRVRLLVAATITYNVIE
                     AVVAISAGTIASSTALIGFGLDSVIEVASATAVAWQFSGKDPEARERTALKVIAVSFFA
                     LAAYVTVEAVRTLFGADPAEHSPVGIALAAVSLLVMPFLSYAQRRAGRELGSASAVADS
                     KQTLLCTYLSGVLLVGLLLNSLFGWYWADPLVALVIAAVAIKEGREAWRGEHCC"
     gene            complement(5485..5811)
                     /locus_tag="NQK81_RS00525"
                     /old_locus_tag="NQK81_00525"
     CDS             complement(5485..5811)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032726.1"
                     /locus_tag="NQK81_RS00525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00525"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257486514.1"
                     /transl_table=11
                     /translation="MLTCETQGAALARLGRALADPNRCRILVALLDGVSYPGLLAEQLG
                     LSRSNVSNHLACLRGCGLVVATYEGRQVRYSLADAHLARALRELVQVVLAVDTAEPCLD
                     EVLR"
     gene            6266..7687
                     /locus_tag="NQK81_RS00530"
                     /old_locus_tag="NQK81_00530"
     CDS             6266..7687
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159827.1"
                     /locus_tag="NQK81_RS00530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00530"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_257486515.1"
                     /transl_table=11
                     /translation="MTVTESDTSAEGVQGPENPQLSLGRAAARNLATTTKSVPQMQGIS
                     SRWLLKSLEWVQVNGGAYRVNRRLNYAVGDGRVTFSKAGAEVSVIPAELGELKPLKGYD
                     DEEVLAELARRFEQQEVAAGDVLVEFGHRADRVYLIAHGKITKTGPGHYGDETALGVVK
                     DGDYFGAQTLVSDDGIWEFTAKATTACTVLTLTRQDFERVLEQSESLQAQIEQAAQDSG
                     RANDFGEAEIDISSGHDGEPLLPGTFVDYETSPREYELSVAQTVLRVHSRVSDLYNQPM
                     DQTEQQLRLTIEALRERQEHEMINNKDFGLLHNADFTQRIATRTGPPTPDDFDDLLALV
                     WKEPGFFLAHPRTIAAFSRECSKRGIYPTGTDLGGHKVPSWRGVPILPCNKIPVSQTST
                     SSVLLIRTGEKNQGVVGLRQIGLPDEYEPGLNVRFMGISEQAIISYLVSTYYSAAVLVP
                     DALAVLEAAELGREG"
     gene            7684..9072
                     /locus_tag="NQK81_RS00535"
                     /old_locus_tag="NQK81_00535"
     CDS             7684..9072
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334401.1"
                     /locus_tag="NQK81_RS00535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00535"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_257486516.1"
                     /transl_table=11
                     /translation="MTATTPEADRRLSLGPAAARNLATTTKTRPQMQSITPRWLLKMLP
                     WIEASGGTFRVNRRLTYAIGDGRVSFTNVGTEVRVVPQELAELALLRGFDDEDTLTALA
                     DRFVQHEYQPGETIVGHGSPLDEVVLVAHGKIAKVVPGEYGAEASVGSMADGDHFGDEM
                     LAGIDRNWPFTAKAVTPVIVLTLRAEDFADLNGRSEAMRRHVQDMLAHKGKPQNAKGEA
                     EIGMSSGHDGEPLLPGTFVDYEISPREYDLAVAQTALRVHTRVTDLYNGPMNQFDEQLR
                     LTVAALRERQEHDLINNREFGLLHNADLKSRFQTRSGPPTPDDMDELVSRRRKTKFFLA
                     HPKAIAAFGRECTRRGLYPEGTTVDGKIVGAWRGVPLLPCDKIPITERGTSSILAMRTG
                     VEDNGVIGLHQTGLPDEYEPGLNVRFDGINEQAVASYLVSTYYSAAVLVPDALGVLENV
                     EVAR"
     gene            9111..9974
                     /locus_tag="NQK81_RS00540"
                     /old_locus_tag="NQK81_00540"
     CDS             9111..9974
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032723.1"
                     /locus_tag="NQK81_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00540"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_126733076.1"
                     /transl_table=11
                     /translation="MTIARTPAPAKVLRTEYQKSVASYWNKEKDPVNLRLGDVDGLYHH
                     HYGVGEVDWSVLEGPENTRDERIIAEMHRLETAQADVLLDHLGDVKPDDRLLDAGCGRG
                     GTSIMANARFGCHVDGISISEKQVEFANHQAEIRGVADRVRYHFRNMLDTGFETGSRKA
                     IWNNESTMYVDLHELFAEHARQLEFGGRYVTITGCYNDVTGGRSKAVAQIDQHYTCNIH
                     PRSEYFKAMTANGLVPISVVDLTPDTIPYWELRAKSSVATGIEGPFLDAYREGSFHYLL
                     IAADRV"
     gene            10001..11131
                     /locus_tag="NQK81_RS00545"
                     /old_locus_tag="NQK81_00545"
     CDS             10001..11131
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159832.1"
                     /locus_tag="NQK81_RS00545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00545"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_257486517.1"
                     /sec_met_domain="T1TS (E-value: 4.1e-55, bitscore: 186.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQGALATLLAGPSGLGTSAARLASRLTAVPQAAPPPAEPALDP
                     AYAYRPWGDGSAPPLYCPVTERINDPLAEEVDRRLVRWAGECGFDEEECEQIGKAGFGR
                     LVMLAHPDCEDPDRLLISARLNAAWWAADDLYADDTSLGAVPAELPPKLALAMAAMDPV
                     PSLGEFSRDLDETLRNDRVLVALGSATDFLRRSGTAAQVQRVCYSTFAMFVSWTAYAAW
                     RHSGKYPPAWEYLAARQHDSFYTSMTLIDVLGGYELTSNLYYDPRVREAAIQAGTASVL
                     VNDVHSVTKDLEDESPPCNAVLLIADDRKCSIEEATAITVELHNDVVRDFQSAHEKLSA
                     VPSAELQRFLRGLRGWMGGGFEWHSTSPRYRTKPSV"
     gene            complement(11196..13187)
                     /gene="ligA"
                     /locus_tag="NQK81_RS00550"
                     /old_locus_tag="NQK81_00550"
     CDS             complement(11196..13187)
                     /EC_number="6.5.1.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="ligA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635616.1"
                     /locus_tag="NQK81_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00550"
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="WP_257486518.1"
                     /transl_table=11
                     /translation="MNARDRIQELADQIVVLRDAYYRGSPKVADADYDAIEDELRGLIE
                     ANPELAPDPNPLEQVGAPAILHAPIRHSRPMLSLEKATKPEQVEAFFARFPGQPVVVMP
                     KLDGLSLALVYENGRLARAVTRGDGTTGDDVTMLVRALTDGVPDKVDAPGRVEVRGEAV
                     MLRSTFAAYNKVHPDKPLINPRNAAAGTLRAKDPATVAERRLQFFAFDLSTEPESAETD
                     LDGALRTLGFAAADMRHCEDAEAAQAVITNIEQQRNELDYDLDGAVLRLADRDAYAAAG
                     TRSSSPRGALAFKFAAEEKTTVLADVVWDVGKTGKIAPVAWLEPVFVGGGTVTRATLAN
                     QEVIKARGIKIGDTVLVRRAGDVIPFVAGVLDAAKRTGEEREIVPPSVCPSCEEPLTEQ
                     GNSRELFCTNVACPAQTVRRLIHWSSRAAADIDAIGGVWIERLAEAGILEHPSDFYRLT
                     KEKLLEFDRIGEISASRMIESIDASRAVGLRRALIGLAIPMASEGTAARLCRAGFGSLE
                     AVADAGEEGLVAVEDIGPKVAASLIEHLTRLRPELERLREVGVSLDVREEDLPPVVAAG
                     APLEGKTVVVTGSISDPRSGEKVPRPTFQRLCERAGATIASSVSANTDMLITGADVGAS
                     KLTKAEKLEVEVVDQGVVWGQLIEAGVV"
     gene            complement(13242..14339)
                     /locus_tag="NQK81_RS00555"
                     /old_locus_tag="NQK81_00555"
     CDS             complement(13242..14339)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334395.1"
                     /locus_tag="NQK81_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00555"
                     /product="calcium:proton antiporter"
                     /protein_id="WP_126733073.1"
                     /transl_table=11
                     /translation="MAASRRRFPVSWTTVMPVLAIVVLALSWGRDLGPVPVVIVALALG
                     GTVLAAVHHAEVVAHRVGEPFGSLVLAIAVTVIEVALIVTMMSSGGPEAGTLARDTVFA
                     AVMITMNGIAGISLMVGARRYGETHFNPEGSGGALATVATLASVSLVLPTFTTSTPGPA
                     FNGTQLTFAAVASLLLYGLFVLTQTVRHRDFFLPVDSEGSVKEEEHAEPPSNKAALTSL
                     GLLLVALVAVVGLAKVESPAIEAGVRAAGFPQSFVGVVIAMLVLLPETLAATRAARRDR
                     MQTSLNLAYGSAIASIGLTIPTIALASIWLDGPLMLGLGATHIVLLALTIAVSVLTVVP
                     GRATRLQGGVHLVLLAAFLVLAVSP"
     misc_feature    complement(14354..14367)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            complement(14527..15063)
                     /locus_tag="NQK81_RS00560"
                     /old_locus_tag="NQK81_00560"
     CDS             complement(14527..15063)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334394.1"
                     /locus_tag="NQK81_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00560"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_257486519.1"
                     /transl_table=11
                     /translation="MRADAARNLEALLTTGARMLAQDPSASISAIAADAGVDRRTVYRR
                     FASREELLAAIYDSRLTAVEKVVSAARFTETAIPVALHRYVEGIIEVNRRWPVELTRMR
                     AEPSIQDRRSRLSAEVETFLQRATDEGFLRADIPNGWAGRLLIQLLHLASQEDMDAPRA
                     ADLLVETFLNGVGAR"
     gene            15140..16600
                     /locus_tag="NQK81_RS00565"
                     /old_locus_tag="NQK81_00565"
     CDS             15140..16600
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032718.1"
                     /locus_tag="NQK81_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00565"
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_257486520.1"
                     /sec_met_domain="Aldedh (E-value: 2.5e-152, bitscore:
                     506.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITNDKLFVGGEWTTPSEPTRLDIVSPHDQSVLGRVVQALPADVD
                     RAVAAARAAFDEGPWPGTSPGERIEVLRRLNALRAARADEIAKLISAENGSALWFTRAG
                     QPGVGRMAVSYLKAAEDFGWEETLTPSDPSSPFRSIVRREPIGVVAAIIPWNSPFSASM
                     AKIVPALLAGNTVVLKVSPENSLSMSLLADLLAESGLPAGVISVLPADRETSEYLVKHP
                     GVDKIAFTGSTAAGRRIASLAGERLKRVSLELGGKSAAVILPDAVLEDVIAGLKFGSLL
                     NNGEACIAQTRILAPRARYDEVVARLKEMMESLVVGDPADEKTFIGPMVRPDQRQRVRD
                     YIGIGVAEGARLVTGGSEVPAGLDKGNYVTPTLFADVDSTMRIAKEEIFGPVLVVIPYE
                     DEDDAVRIANDSEYGLSSGVWSADEDRALAVARRMRTGTVTVNGAPIGFDGPFGGYKAS
                     GIGREYGVAGLAQYVELKTITKGERRGS"
     gene            complement(16572..16823)
                     /locus_tag="NQK81_RS00570"
                     /old_locus_tag="NQK81_00570"
     CDS             complement(16572..16823)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635612.1"
                     /locus_tag="NQK81_RS00570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00570"
                     /product="hypothetical protein"
                     /protein_id="WP_192744192.1"
                     /transl_table=11
                     /translation="MTAQRTITDEIGEIGVWLMGEFGGRVPAAVISRVLNASKRDLEGR
                     IDPEELGEMFHALCRFRLQRIVAADERITVKIPVVRPS"
     gene            17158..17589
                     /locus_tag="NQK81_RS00575"
                     /old_locus_tag="NQK81_00575"
     CDS             17158..17589
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334391.1"
                     /locus_tag="NQK81_RS00575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00575"
                     /product="hypothetical protein"
                     /protein_id="WP_257486521.1"
                     /transl_table=11
                     /translation="MSHAGWHTGARIGTSTADGRMLAYHDSGVEAECVFREGERTLFNI
                     MSTGYGSDTGERGFAVWSRRPGVLGAIDTGVTRLEVTGPDGDVVQAAIVAHTFAVDVDL
                     GPVPQTVDEVFAPWEPPELTVRVYGEGDSLRYEGPLLTA"
     gene            complement(17798..19261)
                     /locus_tag="NQK81_RS00580"
                     /old_locus_tag="NQK81_00580"
     CDS             complement(17798..19261)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101037.1"
                     /locus_tag="NQK81_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00580"
                     /product="S1 family peptidase"
                     /protein_id="WP_257486522.1"
                     /transl_table=11
                     /translation="MRRARRLGALAASVLAATMALGSPATAETVQSFHTSLDPASVRES
                     MRYLVENYRVSEQEALRRLELQTDSLKLDELLRRDRGAEYGGMWLDQDKGQLVVAMTKP
                     SAAEPYLRAMPARSAVRTQQVQHSLQQLTAARERVAAKVGAGPDAVYLPSVSESENRVV
                     LWERGWVAQEKAAVRAAAAETNAAHQAAAAESGMVVSRVLKNPNALSTANVDLGFCHPL
                     YCTNYGPMRGGLRLDMKRDNGTWGGCTSGFNLRSTGGGFPGKGWVLTAGHCMRTKTNNT
                     PTQHNGNDVLQQHGIEKSSYPYDYAALPYVNDAAATQWLEGQTGRNRVLKYCRNGGMDS
                     NGDTPCGAQATSVDEYITSARKLADIKAGYVVCASGTASSAVNYPDSVDSGAGAGYLVG
                     TRCGRVLSTDVGINTDLCARPGDSGGPLFSQADHAALGILVGNQQSRSGPCQAGELNNY
                     APIETITTDLSERIASQGSTFAVITTPNG"
     misc_feature    19324..19338
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.44"
                     /tool="antismash"
     gene            complement(19385..19786)
                     /locus_tag="NQK81_RS00585"
                     /old_locus_tag="NQK81_00585"
     CDS             complement(19385..19786)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_00585"
                     /product="hypothetical protein"
                     /protein_id="WP_257486523.1"
                     /transl_table=11
                     /translation="MTLQPDNTKTPDNEPPQRVKVVIEHAEKPVRRVATSAEMIRTARP
                     LLRTPGRHRKEPARDGWLCLAMAVLAGWAPTLRMCLLLTLGGGIVVGVVRISSPQIGVS
                     AGTSVGLLTLFCAWIVKSRQGKQRREPSL"
     misc_feature    complement(19778..19780)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20148..20162
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.35"
                     /tool="antismash"
     misc_feature    20149..20161
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.42"
                     /tool="antismash"
ORIGIN
        1 aaatggagcg cggcggccgc ggaggtactc gccgcgacgg cgcagcagcc cgaaaccgcc
       61 gccctcgtcg ccgccgttca gcggcgtcat gacgacgagg tggtctccct gctcgccgaa
      121 catgcgcggc ggctccgcct cgaacccgcc ttgccgctcc acgaggccgt cgtgatgctg
      181 ggcgcgctgg gcatcgggct cgccttgcgt caggcggtcg caccggccgc cgaccccgcc
      241 gcgatcctca cgcacgtgct ggactcggtg ttcccgcccg aggcaacgtg acggcaggtc
      301 cggacgtact cccggtgaca ccggggcggg gttcgatgct gtgggccggg cgggcgcagc
      361 acccgcgaaa gtggtttccc gagtacacgg tgatgatcat cgccatcggg atggccgcgg
      421 tcctgatcgt cttcgggcat ccgggctcgg cgttgccctt ctacgccggc atgttgctcg
      481 cgttcggtgt tttctcgtcc agcgcgtgaa cgatcgtcga gcacgagacc gcgctctgtc
      541 ctacctggtc accactcagc ggatcatcgt cgccgcgagc cggcccaacg gcaccgaatt
      601 ccgccgggtc tggctgcgtt acgtccagca tccgccgaag gtcaaagccg ggaaagcagg
      661 cggcggcacg atcactttcg gcggtgtgcg gggccgccgt cagctccggt cctggaactg
      721 agggccatcg ccgatgccgc gaatgtggcg aacctgatcc ttcaggcaca gcaccgggcc
      781 gccggaagga cctacactca ggcgccgtga tcgattcctt caccaccgcc gatctcgtgg
      841 acgaacacgg cgaccggctt cgtgtctgcg acacccagtt ccgccagttc ggcgggcacc
      901 ggaagttctc gggtccgatc cgcaccgtct cctgtcacga ggacaacggc ctggtcaaga
      961 agctcctggc cacccctggt gacggcgccg tgctggtggt cgacggtggc ggctcgctgc
     1021 acagcgcgct caccggcgac atgatcgcga agtccgccgt cgacaacggc tgggcgggca
     1081 tcgtggtcaa cggcgcggtg cgcgacagcg ccgagctcgc cgggctcccg ctcggagtta
     1141 aggcgctcgg caccaacccg cgcaaaagtt ccaaggcggg cgtcggcgct gtcgacgtcc
     1201 cggtcggttt cgggggagtg acgttcactc ctggagacac gctttacgcc gacgatgacg
     1261 gcgtcgtgat ccttcccccg gccggatcct gatccggctc agacgacgat gacccggcgg
     1321 ccgcgcgtgt gcccggcgcg gctgtcggca tgtgcggccg cggcgtcggc gagcggatag
     1381 gccttctcga ccgggatgtg cagcttcccc cgcgcgatga ggtcgacggc ctcggccagc
     1441 gcgtccggca cgctcccggc gacgccggag aaacggacgc cgaactcggg cgcgccgaga
     1501 tcggcgatgg agacgacctt ccccggatcc ccggtgagct cgaccagctc ggcgatcacc
     1561 ccggacccgg ccagatcgag agcggcgtcg acccggccga accgccgcac ccgctcgacc
     1621 cagccctcgc cgtaggtcgt ggctagcgcg cccaggccgc gcaggtagtc ctggttcgcg
     1681 gcacccgccg tgccgatcac ctcgatgccg cgttcgcgag cgatctgcag caccgccgac
     1741 ccgaccccgc cggacgcgcc gctgaccagc agcttctcgc ccggccgcgc tccgacttcg
     1801 cggatcagcc gcagcgcggt ctcgaccacc gaagggtatc cggcagcctc ctcgaaggtc
     1861 agtccgtcgg gcatcacggc ccaggccgtc agcacggcga actcggcata agtgctcgcg
     1921 ccctcgccga acacgaagtc gccgacgtcg actccgacga caccttcgcc gacctcgtcc
     1981 acgattccgg cggcgtccag gcccacgccg gacggcaaca cggtcggatg tgcgccgagg
     2041 acctggcctt cacggattct ccagtcgacg gggttcaccc cggcggcccg caccgcgatg
     2101 cgcacctggc ccgggccggc gtgcggatct tcggcgtcga cgagctgcag gacttccgga
     2161 ccaccgaact cggtgaagat cactttcttc atgccgtcga acgtagcact aacggttagg
     2221 attttgaaac cgttgttgtt ttgcatctga tagcgtcccc gcatgaccgt gccgaccgga
     2281 cgtcgtgagc gaaagaaggc cgccacccgt cagaagatcg ccgagaccgc actgcggctt
     2341 ttcctggaac gcgggtacga cgcggtgggc atccgcgagg tggccgcgga agccgacgtc
     2401 gccgtcacga cgctcttctc ccacttcgcc tcgaaagagg ccttggtgtt cgagcaggac
     2461 gcgaacttcg agcagggcct cgcgcgggcg gtcaccggaa gggcgccgca tgagccgctg
     2521 attcccgcgc tgcgtcacga ggtccacgcg atggtgcgcc actgcacggc ggacggcgcc
     2581 gccccgatct ggcgcatgat cgacgagtcg cccgcgctgc gggagtacga ggactcgatg
     2641 cggctacgtc acgcggagac gctggcggcg gccatcgcgg cggacccgga gtcggcgcgg
     2701 tccgcgaccg cctgccggac gatcgcgaga ttcgtgctcg acgcctattc gctcggccgg
     2761 gaggccgccg atccggaggt agcggtgaac gagatcttcc ggatgatcga agcggcctgg
     2821 gaagccaccg gccccgccta gtgcttgcaa tctgccacca gttgggacta ccgtctccgc
     2881 aaagcggttg cacatcacaa tcggagggga tcgccgtgct gacacaggtc gcggagggtg
     2941 tgctggtcca ccagagcgcg ttgctcgaga acaacgcggt cgtcgtggag ggcgcggacg
     3001 gtgttctgct cgtcgacccc gggctcacgg gcgccgaaat ggcctgcctc gcgcacgacc
     3061 tggccgattc gggccgcccg gtggtggcgg gtttcgcgac gcatcccgac tgggatcacg
     3121 tgctctggca ccccgaactg ggtgacgcac cccgttacgg caccgcccgg tgcgcggagt
     3181 atctgcgtga tctgcggtcc aacccggatt ggaagaccgg cgtcgccgag gggctgccac
     3241 cggaaatcag cggtgaggtg ccgctggacc tgttcggcct gatcaccggc ctgcccgccg
     3301 gaaccacccg gattccctgg gacggcccgc gaatccggat cgtcgagcac ccggcccacg
     3361 cccccggtca tgcggcgctg gtgatcgagg aacgcggggt gctggtcgcc ggcgacatgc
     3421 tttccgacgt ccttgtcccg atgttcgacg acgacggcga tccgctcgag gactacctcg
     3481 ccgggctccg ggtgatcgaa gacgtggcgg gcgacgccgc cgtcgtcgta cccggccacg
     3541 gggccgtcgg cggagccggt gcggtacggg cacgcatcga cttggaccgg gcgtacgtac
     3601 acgccttgcg agacggtcgg acgccggacg acccgcgaat cgggtcgtcc gcgaagcctg
     3661 gttgggaatg ggtgagggat ctgcacgacg ggcaggccca aagcctcgcc cggagacagg
     3721 cgtcagcctc tcggcatgac gcagagctcc cgtgactccc cggacttgaa gtcgtagacg
     3781 acgggattgc cgtactcgta gccgggcacg gtgttgcagt ccgagcccga cgcggacgcg
     3841 agctgggcga tcaccgagta gttggcggag ctgtccgaac agtggacccg gacggcgctg
     3901 gcgctgaacg cgccgttgct gccggcgtct tcgtcggccg agatgcaatc cccggcctgc
     3961 gcggagaacg ggtcggggtc gacctggggg acatcggcgc cggacgagcc gccgctcgtg
     4021 gtgatcgcca cggtcaccgc gagcgccccg ccggtgacga cgaccgccgc cgcggcgatc
     4081 ccgacgatca gcccggtctt cggggccttc ttcggcggcg cgacgggata ctgctgccag
     4141 atcggcgact gttgctgagg gtaggtcacg tcatcaggat cggcctcgcc gatgaaattc
     4201 cgatgacacg cttcacttac gggcgacgag ccgttccacg agcccgagct tgaaccgttc
     4261 ccggtgctcc acggccaagc cgagaccgtc gatcttctcg agcgggcggc gaaggaagtg
     4321 ttcgcccgcc atcggcacgg tgatcttctc ggccatccat tgcaggccgc ggaccgcgcg
     4381 cgacgagctc gcgatgtggt cgagcaggat gagcctgccc cctggccgga gcaccctggc
     4441 catctcccgt agcgccttgc cgtcgtccgg gatggcgcag agcccgagcg tgcagaccac
     4501 ggtgtcgaac gaatcggcgt cgaagggcag gtgatgggca tcggcccgcc gtagcgtcac
     4561 cggacggccg agacgttcgg cgcgagcgcg ggcgatggag agcatgccgt cactgaggtc
     4621 gatgccggtg agcgtgacgc cctcggcata gagcggcagg ttcaggccgg tccccacggc
     4681 gacttcgagg acttcgccgt cggcctggcc gcaggcccac gcacgggaat ccccgaagag
     4741 cttccggtcc aggaactgca tctcccggtc gtagttgcgg gatttggtgt cccagtaacg
     4801 gttccatcgg gcgggccggg tcatgacgct cctttcagca gcagtgctca ccgcgccagg
     4861 cctcacggcc ctccttgatc gcgacggcgg cgatgacgag cgcgaccagc ggatccgccc
     4921 agtaccagcc gaagaggctg ttgagcagca gcccgacgag cagcacaccg gaaagatagg
     4981 tgcagagcaa ggtctgcttc gagtcggcga cggcgctcgc ggagccgagt tcgcgcccgg
     5041 cgcggcgctg ggcgtaggac aggaacggca tcacgagcag tgagaccgcc gcgagcgcga
     5101 tgccgacagg ggagtgctcg gcggggtcgg cgccgaacag ggtgcggacc gcttcgacgg
     5161 tgacgtatgc ggccagcgcg aagaaggaca ccgcgatgac cttgagcgcg gtgcgttcgc
     5221 gggcttcggg gtccttcccg gagaactgcc aggcgaccgc cgtggccgaa gcgacctcga
     5281 tgaccgagtc caggccgaaa ccgatcagtg ccgtcgacga ggcgatggtg cccgccgaga
     5341 tggcgacgac cgcctcgatg acgttgtagg tgatcgtggc ggcgaccagg agccggaccc
     5401 gctgggaaag cacggcacgg cgctccgggg ccactgtgga cttcgcggtg cagcagccgt
     5461 ccgcgcagga atcgctctcc acgctcaccg gagcacctcg tccagacagg gctcggcggt
     5521 gtcgacggcc agcacgacct ggacgagttc ccgcagggcg cgggcgaggt gcgcgtccgc
     5581 cagtgagtag cggacctgcc tgccttcgta ggtggccacg accagtccgc aaccccgcag
     5641 gcaggcgaga tggttcgaca cgttcgagcg gctcagtccg agttgctcgg ccagaagccc
     5701 gggatagctc acgccgtcga gcagggcgac caggatccgg caccggttcg ggtcggcgag
     5761 ggcgcggccg agccgggcga gcgcggcgcc ctgggtctca catgtcagca cagccaggac
     5821 agtacagcga acgctgacat gtcagcaagg gctgaaccat tgacccgacg gagtgtccgg
     5881 acgcgaccct ctgtttcgtc gcggtctgtc aagccatcgc cgaacatgga caccggagcg
     5941 acccgaaaga gtccggtgtg gccactccaa cggtcgcacc ccgggcacgc gggggagtcc
     6001 cggcgtgccc cggcatgaca cctcagcaca attgctggcc cgattgcgtg gccacgggaa
     6061 aacgtcgtgt cacgtttcca aaaggtttcc cgtacaaagg gaattcggca ttcgggtggc
     6121 cttgtcgcat tacctgaaag tgcgcttgtg cgggaaaaac cccttgctat gttgatcgtg
     6181 cggggccgca cttcggggca tgaccggcgc gccgcgaatt gtggatcttg tttgttcaca
     6241 cgactatcga agggtggacc ttgctgtgac cgtgaccgaa tcggacactt ccgccgaagg
     6301 tgtccagggg ccggaaaatc cgcagctgag tttgggcagg gccgccgcgc gcaacctggc
     6361 gacgaccacc aaatccgttc cgcagatgca gggaatttcg tcccggtggc tgctgaaatc
     6421 gctcgaatgg gttcaggtga acggcggtgc ctaccgggtc aaccggcggc tgaactacgc
     6481 ggtcggtgac ggacgggtga ccttctcgaa ggcgggcgcc gaggtgagcg tgatcccggc
     6541 ggaactggga gaactgaagc cactcaaggg atatgacgac gaagaggtgc tcgccgaact
     6601 cgcccgccga ttcgaacagc aggaagtggc ggccggcgac gtgctggtcg aattcgggca
     6661 ccgggccgac cgggtctacc tcatcgcaca cggcaagatc accaagaccg gccccggtca
     6721 ctacggtgac gagaccgcgc tcggcgtggt caaggacggt gactacttcg gcgcgcagac
     6781 cctcgtctcc gacgacggca tctgggaatt caccgccaag gcgaccaccg cctgcaccgt
     6841 gctcaccctg acccgccagg acttcgagcg cgtactggaa cagtccgaat cgctgcaggc
     6901 gcagatcgaa caggccgcac aggactccgg gcgcgccaac gacttcggcg aggccgagat
     6961 cgacatctcc tccgggcacg acggcgagcc gctgctgccg ggcacgttcg tcgactacga
     7021 gacctcgccg cgcgagtacg aactcagcgt cgcccagacg gtgctccggg tccacagccg
     7081 ggtgtccgat ctctacaacc agccgatgga ccagaccgaa cagcagttgc gcctgaccat
     7141 cgaggcgctg cgtgagcggc aagaacacga aatgatcaac aacaaggact tcggcctgct
     7201 ccacaacgcc gacttcaccc agcgcatcgc gacgcgcacc ggtccgccca ctccggacga
     7261 cttcgacgac ctgctcgcgc tggtgtggaa ggaacccggc ttcttcctcg cgcatccgcg
     7321 cacgatcgcc gcgttcagcc gcgagtgcag caaacgcggg atctacccga ccggcaccga
     7381 tctcggcggg cacaaggtgc cgtcctggcg cggcgtgccg atcctgccct gcaacaagat
     7441 cccggtcagc cagaccagca ccagttccgt cctgctgatc cgcaccggcg agaagaacca
     7501 gggcgtcgtc ggcctgcggc agatcggcct gccggacgaa tacgagcccg gcctgaacgt
     7561 ccggttcatg ggcatctcgg agcaggcgat catctcctac ctcgtcagca cctactactc
     7621 cgcggccgtc ctcgttccgg acgcgctcgc cgtcctcgaa gccgccgaac tcggccgcga
     7681 aggatgaccg ccacgacgcc ggaggccgac cggcggctca gtctcggccc cgccgccgcg
     7741 cgcaacctgg cgacgaccac caagacgcgg ccgcagatgc agagcatcac gccgcgctgg
     7801 ctgctgaaga tgctgccctg gatcgaggcg tccggcggca ccttccgggt gaaccggcgg
     7861 ctgacctacg cgatcggcga cgggcgggtg agcttcacca acgtcggcac cgaggtccgg
     7921 gtcgtcccgc aggaactcgc ggagttggcc ctgctgcggg gtttcgacga cgaggacacg
     7981 ctgaccgcgc tcgccgaccg gttcgtgcag cacgagtacc agccaggcga gaccatcgtc
     8041 ggtcacgggt ctccgctcga cgaggtggtg ctggtcgcgc acggcaagat cgccaaggtg
     8101 gtacccggcg agtacggcgc cgaggcctcg gtcggcagca tggccgacgg cgaccacttc
     8161 ggtgacgaaa tgctcgccgg catcgaccgg aactggccgt tcaccgcgaa ggccgtcacg
     8221 ccggtcatcg tgctgacctt gcgtgcggaa gacttcgccg acctcaacgg ccggtccgag
     8281 gcgatgcgcc gccacgtcca ggacatgctg gcgcacaagg gaaagccgca gaacgccaag
     8341 ggtgaggccg agatcgggat gtcgtccggg catgacggcg agccactgct gccgggcacg
     8401 ttcgtcgact acgagatctc gccgcgcgaa tacgatctcg cggtcgcgca gacggcgctg
     8461 cgggtgcaca cccgggtgac cgatctctac aacgggccga tgaaccagtt cgacgagcag
     8521 ctccggctga ccgtggcggc gctgcgcgag cggcaggagc acgacctgat caacaaccgc
     8581 gagttcgggc tgctgcacaa cgccgacctc aaatcgcggt tccagacgcg gtctggtccg
     8641 ccgacccccg acgacatgga cgaactcgtc agccgtcgcc gcaagacgaa gttcttcctc
     8701 gcccatccga aggcgatcgc cgcgttcggc agggaatgca cccgccgcgg tctgtatccg
     8761 gagggcacca cggtcgacgg caagatcgtc ggcgcgtggc gcggggtgcc gctgctgccc
     8821 tgcgacaaga tcccgatcac cgagcggggc acgtcctcga tcctcgccat gcggaccggt
     8881 gtcgaggaca acggtgtgat cgggctgcac cagaccggcc tgcccgacga gtacgagccg
     8941 ggcctgaacg tgcgcttcga cggcatcaac gaacaggccg tcgcctccta cctggtcagc
     9001 acctactact cggccgccgt gctcgttccg gacgccctcg gtgtcctgga gaacgtcgag
     9061 gtcgcgcggt gaccacaacg aacaacaacg ctccagaaag gaccacacac gtgaccatcg
     9121 cccgtactcc cgctcctgcc aaggtgctgc gcaccgagta ccagaagtcg gtggcgtcgt
     9181 actggaacaa ggagaaggac ccggtcaacc tgcgtctggg cgatgtggac gggctctatc
     9241 accaccacta cggggtcggc gaagtcgact ggtcggtgct ggagggcccc gagaacaccc
     9301 gcgacgagcg gatcatcgcc gaaatgcacc gcttggagac cgcgcaggcg gacgtcctgc
     9361 tcgatcacct cggcgacgtg aagccggacg accggctcct cgacgccggc tgcggacgcg
     9421 gcgggaccag catcatggcc aacgcgcggt tcggctgcca cgtcgacggc atctcgatct
     9481 cggagaagca ggtcgagttc gccaatcacc aggccgagat caggggcgtc gccgaccggg
     9541 tgcgctacca cttccgcaac atgctcgaca ccggcttcga aaccggctcg cgaaaggcga
     9601 tctggaacaa cgagagcacg atgtacgtcg acctccacga actcttcgcc gagcacgcgc
     9661 ggcagctgga gttcggcggg cggtacgtca ccatcaccgg gtgctacaac gacgtgaccg
     9721 gtggccggtc caaggccgtc gcgcagatcg accagcacta cacctgcaac atccacccgc
     9781 gcagtgagta cttcaaggcc atgacggcga acggcctggt gccgatctcg gtcgtggatc
     9841 tgacgccgga cacgatcccg tactgggagc tgcgggcgaa gtcgtcggtg gcgaccggga
     9901 tcgaagggcc gttcctggac gcctaccgcg aaggcagctt ccactacctg ctgatcgccg
     9961 cggaccgcgt ctgatcccgc gagaccatcg gagcgaagcg atgaccgaac agggtgcgct
    10021 cgccacactg ctggccggtc cgagcggcct gggcacgtcc gccgcccggc tcgcgtcccg
    10081 gctgaccgcc gttccgcagg cggctccacc gcctgcggaa cccgctctcg acccggcgta
    10141 cgcctaccgg ccgtggggtg acgggtcggc gccgccgctg tactgccccg tcaccgaacg
    10201 gatcaacgac ccgctcgccg aggaggtcga ccggcgcctc gtccggtggg cgggggagtg
    10261 cgggttcgac gaggaggagt gcgagcagat cgggaaggcg ggcttcggca ggctggtgat
    10321 gctcgcccac ccggactgcg aggatcccga caggctgctg atctccgcgc ggctcaacgc
    10381 cgcgtggtgg gcggccgacg acctctacgc cgacgacacc tccctcggcg ccgtgcctgc
    10441 cgagctgccg ccgaagctcg cgctggcgat ggcggcgatg gacccggtgc cgtcgttggg
    10501 tgaattcagc cgcgatctcg acgaaacact gcggaacgac cgggttctgg tggcgctggg
    10561 ctcggcgacg gacttcctgc ggcgatccgg gaccgccgcg caggtccagc gcgtctgcta
    10621 ctcgaccttc gcgatgttcg tgagctggac cgcctacgcc gcttggcgcc acagcgggaa
    10681 atacccgccg gcgtgggaat acctcgcggc gaggcagcat gacagcttct acacctcgat
    10741 gacgttgatc gacgtcctcg gtggctacga actgacctcg aacctgtact acgacccccg
    10801 ggtccgggag gcggcgatcc aagcggggac ggcgtccgtg ctcgtcaacg acgtgcactc
    10861 ggtcaccaag gatctggagg acgagtcgcc gccctgcaac gcggtcctgc tgatcgccga
    10921 cgaccggaaa tgctcgatcg aggaggccac ggcgatcacc gtcgaattgc acaacgacgt
    10981 cgtccgggac ttccagtccg cgcacgagaa gctcagcgcg gttccttccg ccgaactgca
    11041 acggttccta cgcgggttgc gagggtggat gggcggcggt ttcgaatggc actcgacgag
    11101 cccgcggtac cggacgaagc ccagcgttta gtcctctgga tgcggtagtt cgcgacacga
    11161 acttccgcat tcagaggact aaacgcggaa ggaggctaga cgaccccggc ctcgatcaac
    11221 tgaccccaga ccaccccttg gtccacgacc tcgacttcga gtttttcggc cttggtgagc
    11281 ttgctcgccc cgacgtcggc gccggtgatc agcatgtccg tgttcgccga gaccgaagac
    11341 gcgatggtcg cgcccgcccg ttcgcacagc cgctggaagg tcgggcgcgg caccttctcg
    11401 ccggagcggg ggtcgctgat cgagccggtg accacgaccg tcttgccctc cagcggcgca
    11461 ccggccgcga cgaccggcgg caggtcttct tcgcgtacgt ccagcgagac tccgacctcc
    11521 cgcagccgct cgagctcggg acgaagccgg gtgaggtgct cgatcaggga cgcggcgacc
    11581 ttgggaccga tgtcctccac ggcgacaagg ccttcctcgc cggcgtcggc gacggcttcc
    11641 agcgaaccga accctgcccg gcacaggcgc gcggcggtgc cctcggaggc catcgggatc
    11701 gcgagcccga tcagcgcccg gcgcagtccg acggcccggc tcgcgtcgat cgactcgatc
    11761 atgcggctgg cggagatctc gccgatgcgg tcgaactcca gcagcttttc cttggtgagg
    11821 cgatagaagt ccgacgggtg ctcgagaatc ccggcctcgg cgagccgctc gatccagacc
    11881 ccgccgatcg cgtcgatgtc cgcggccgcg cgcgacgacc agtggatcag ccgccggacg
    11941 gtctgggcgg ggcaggcgac gttggtgcag aacagttccc ggctgttgcc ctgttcggtc
    12001 aacggttctt cgcacgacgg acagaccgac ggcggcacga tctcccgttc ctcgccggtg
    12061 cgtttggccg cgtcgagaac gcccgccacg aacgggatca cgtcgcccgc gcggcgtacc
    12121 agcaccgtgt cgccgatctt gatgccgcgg gccttgatca cctcttggtt ggccagcgtc
    12181 gcccgggtga cggtgccccc gccgacgaac accggctcca gccaagcgac gggcgcgatc
    12241 ttgccggtct tgccgacgtc ccagacgaca tcggcgagca cggtcgtctt ctcctcggcg
    12301 gcgaatttga acgccagcgc gccacgcggt gagctggacc tggtcccggc cgcggcgtag
    12361 gcgtcgcgat ccgccagacg cagcaccgca ccgtcgaggt cgtagtcgag ctcgttgcgc
    12421 tgctgctcga tgttcgtgat gaccgcctgg gccgcctcgg cgtcctcgca gtgacgcatg
    12481 tcggcggcgg cgaacccgag cgtccggagc gcgccgtcga gatcggtttc cgcgctttcc
    12541 ggttcggtgg agaggtcgaa ggcgaagaac tggaggcgcc gctcggcgac ggtggctgga
    12601 tccttggcgc gcagggtgcc ggcggcggcg ttgcgcgggt tgatcagcgg cttgtccggg
    12661 tggaccttgt tgtaggcggc gaaagtcgag cgcagcatga ccgcctcgcc gcggacctcg
    12721 acccggccgg gcgcgtcgac cttgtccggg acgccgtcgg tcagcgcccg gaccagcatg
    12781 gtcacgtcgt cgcccgtggt cccgtcgccg cgggtgaccg ccctggcgag cctgccgttc
    12841 tcgtagacca gcgccagcga caggccgtcg agcttcggca tgacgaccac cggctgccca
    12901 gggaaccggg cgaagaacgc ctcgacctgc tcgggtttcg tcgccttctc cagcgacagc
    12961 atcgggcggg agtgccggat gggcgcgtgc aggatggcgg gcgcgccgac ctgctcgagc
    13021 gggttcggat ccggggccag ctctgggttc gcctcgatga gcccgcgcaa ttcgtcttcg
    13081 atcgcgtcgt agtcggcgtc ggcgaccttc ggcgagccac ggtagtaggc gtcgcgaagg
    13141 acgacgatct gatcggcgag ttcttggatg cggtcccgag cgttcacggg gcagagatta
    13201 cccgggacca ccgacagaac accgtccgaa gaggactcgt gtcacgggct gacggcgagc
    13261 accaggaacg cggccagcag gaccaggtgc accccgccct gcagccgtgt cgcgcggccg
    13321 gggacgacgg tcagcacgct gaccgcgatc gtcagcgcca gcagcacgat gtgcgtggcg
    13381 ccgaggccca gcatcagcgg gccgtccagc cagatcgacg ccagtgcgat ggtcgggatg
    13441 gtgagcccga tgctcgcgat cgccgaaccg taggcgaggt tcaggctggt ctgcatccgg
    13501 tcgcgccgcg cggccctggt cgcggccagg gtctcgggca gcagcaccag catggcgatc
    13561 acgacgccga cgaacgactg cgggaaaccc gcggcgcgga cccccgcttc gatcgcgggc
    13621 gactcgacct tcgccaggcc cacgacggcg acgagggcga ccagcagcag cccgaggctg
    13681 gtcagggcgg ctttgttgga gggtggctcg gcgtgctctt cctccttgac ggagccctcg
    13741 ctgtccacag gcaggaagaa gtcacggtgg cgcacggtct gcgtgagcac gaagagtccg
    13801 tagagcagca gcgacgctac cgcggcgaag gtgagctgcg tgccgttgaa ggccggaccg
    13861 ggcgtgctcg tggtgaacgt cggcagcacg aggctgaccg aagcgagcgt cgccaccgtg
    13921 gcgagcgcgc cgccgctgcc ttcggggttg aagtgcgtct cgccgtagcg gcgggcgccg
    13981 accatgagcg agatgccggc gatgccgttc atcgtgatca tcaccgcggc gaacacggtg
    14041 tcgcgggcga gggtcccggc ctcggggccg ccggaggaca tcatcgtcac gatcagcgcg
    14101 acttcgatga ccgtgaccgc gatcgccagc accagcgagc cgaagggttc cccgacgcga
    14161 tgcgcgacca cctcggcgtg gtgcaccgcc gccagcaccg tgccgccgag cgcgagcgcg
    14221 acgatgacca cgggcaccgg gcccaggtca cggccccagc tcagcgccag cacgactatg
    14281 gcgaggaccg gcatgacggt ggtccaggac accgggaatc gtctgcgcga agcggccatg
    14341 ccgtcacctt cgcacactct gcgtgacgtc gccccttcgt gggggtcgtg ggtgacgaag
    14401 ttcttagcgg acatgctgga cgcgctccgc atcgttgatc gggccgaggt cgtcagcagg
    14461 cgaaggaggt cgcgaccccg tcacgaagca acgacgtggc tcgacgcgat cctcctggag
    14521 ggggcgctag cgagcgccga cgccgttcag gaacgtctcg acgagcagat cggcggcgcg
    14581 cggggcgtcc atgtcctcct gcgacgcgag gtggagcagc tggatcagca gccggcccgc
    14641 ccagccgttg ggaatgtccg cgcggaggaa cccctcgtcg gtggcccgct ggaggaacgt
    14701 ctccacctcg gcggaaagcc ggctccggcg gtcctggatg gagggttcgg cgcgcatccg
    14761 ggtcagttcg accggccatc ggcggttgac ttcgatgatg ccttcgacgt agcggtgcag
    14821 ggccacggga atcgccgtct cggtgaaccg ggcggcgctg acgacctttt cgaccgcggt
    14881 cagccgggag tcgtagatgg cggccaggag ttcttcgcgc gaggcgaacc gccgatagac
    14941 ggtgcgacgg tctacgccgg cgtcggcggc gatcgcgctg atggaggcgg aggggtcctg
    15001 agcgagcatc cgcgcgccgg tcgtcaggag ggcttccaga ttgcgggcgg cgtcagctct
    15061 catgccggga atgtatcacg caggcgtggc gttaatgggg ttaagtgcca cttgggtgtg
    15121 acagttatgg aggcagacgg tgatcacgaa cgacaagctc ttcgtcggcg gcgagtggac
    15181 gacgccgagc gagccgacga ggctggatat cgtgtcccca cacgaccaat cggtgctggg
    15241 acgggtcgtc caagcactgc ccgcggacgt cgaccgtgcc gtcgccgcgg ctcgggccgc
    15301 cttcgacgaa ggtccgtggc cggggacctc gccgggggaa cggatcgagg ttctccggcg
    15361 gctgaacgcg ttgcgggcgg ctcgcgcgga cgagatcgcg aaactgatct ccgccgagaa
    15421 cggctcggct ctctggttca cgcgtgccgg gcagcccgga gtggggcgga tggccgtttc
    15481 gtatctgaag gcggccgagg acttcgggtg ggaagagaca ctcacgccct cggacccctc
    15541 gtcgccgttc cgttcgatcg tgcgtcgcga accgatcggg gtggtcgccg cgatcatccc
    15601 gtggaactcg ccgttctccg cgtcgatggc gaagatcgtt ccggcgcttc tcgcggggaa
    15661 cacggtcgtc ctcaaggtct cgcccgagaa ctcgctcagc atgagcctgc tcgcggacct
    15721 gctggcggaa tccgggctgc cggcgggggt gatcagcgtg ctgcccgcgg accgggagac
    15781 cagcgagtac ctggtgaagc accccggcgt cgacaagatc gcgttcacgg gctcgaccgc
    15841 cgccggccgc cggatcgcgt ctttggcggg ggagcggctg aagcgggtca gcctggagtt
    15901 gggtggcaaa tccgcggccg tgatcctgcc cgacgccgtc ctcgaagacg tgatcgccgg
    15961 gctgaaattc ggatcgctgc tcaacaacgg cgaagcctgc atcgcacaga cacggatcct
    16021 cgcgccgcgt gcccggtacg acgaggtcgt cgcccggctc aaggagatga tggaatcgct
    16081 cgtggtcggc gaccccgccg acgagaagac cttcatcggc ccgatggtgc ggcccgatca
    16141 gcggcagcgg gtgcgcgact acatcggcat cggcgtcgcc gagggcgcgc ggctggtcac
    16201 cggcgggtcc gaagtcccgg caggcctgga caagggcaac tacgtcacgc cgacgttgtt
    16261 cgccgacgtc gacagcacga tgcgcatcgc caaggaagag atcttcgggc cggtgctggt
    16321 cgtcatcccc tacgaggacg aagacgacgc ggtccgcatc gccaacgact ccgagtacgg
    16381 gctctccagc ggtgtttggt cggcggacga ggaccgcgcg ctcgccgtcg cacggcggat
    16441 gcgcaccggg accgtcaccg tcaacggtgc accgatcggc ttcgacggtc ccttcggtgg
    16501 ctacaaggcc agcggaatcg gccgcgagta cggcgtcgcc ggcctcgccc agtacgtgga
    16561 gctcaagacc atcacgaagg gcgaacgacg gggatcttga cggtgatccg ctcgtccgcg
    16621 gccacgatcc gctgaaggcg gaaccggcag agggcgtgga acatctcgcc cagctcttcg
    16681 gggtcgatac ggccttcgag gtcacgttta ctcgcgttga gcacccggct gatcacggcc
    16741 gcgggcacgc ggccaccgaa ttcgcccatc agccagacac cgatttcgcc gatctcgtcc
    16801 gtgatcgtgc gctgcgcggt catcggtcgt ccctcttcgc gtcggagtgt cacgacactc
    16861 cgacgggtga ccggaacacc catgacggga tacccgcgag attgctctgc tcggcctaac
    16921 cgcgcggcgc cggttgcacc gaaccgtgca gcgggccgga ccgatctccg ggagaacccc
    16981 gatgtggccg gcagccgggt gtgccagcct cgaacctgac cattgtggac agtcagggag
    17041 gagggcgcac gcgtagtggc cccggcaagt gatgaagaga ccacacgatg gatagcggag
    17101 ttgacggctc tctgtgagct ttaccggtcc gcggaggtcg cgggatcgac ggaggcggtg
    17161 tcacacgcgg ggtggcacac cggagcccgg atcgggacga gtaccgcgga cgggcggatg
    17221 ctggcctacc acgattcggg tgtcgaggcg gaatgcgtct tccgggaggg agagcgcacg
    17281 ctgttcaaca tcatgagcac cggttacggg agcgataccg gcgagcgcgg gttcgcggtg
    17341 tggagcagac ggccgggcgt gctcggagcg atcgacaccg gagtgacgcg gctggaggtg
    17401 accggtccgg acggcgacgt cgtccaggcc gcgatcgtgg cgcacacctt cgcggtggat
    17461 gtggatctcg gtccggtgcc ccagacggtc gacgaggttt tcgccccgtg ggagccgccg
    17521 gagctgacgg tccgggtgta cggcgagggc gactcgctgc ggtacgaagg tcctctgctg
    17581 accgcgtgaa ggtaggttcg agtagcggca acgcccggag gacgtcgtgg acctcttcgc
    17641 agtccgcccg ggcagcccgc cgtgcttgaa cagcgaactc gcgtgcttga aggcgtaact
    17701 cgcgtgattg gagccgcatc acgcgagtta cggcattacg gcccaacgtg taggcgccct
    17761 tcgccacggc gaagggcgcc tacacgtact tgcgaggtca gccgttcgga gtcgtgatca
    17821 ccgcgaacgt ggagccctgg ctggcgatcc gttcgctgag gtcggtggtg atcgtctcga
    17881 tcggcgcgta gttgttcagc tcaccggcct ggcaggggcc cgatcgggac tgctggttgc
    17941 ccacgaggat gcccagtgcc gcgtggtcgg cttggctgaa cagcggtccg ccgctgtcac
    18001 ccggacgggc gcagaggtcg gtgttgatgc cgacgtccgt ggagaggacg cgtccgcagc
    18061 gggtcccgac gaggtagccg gcgcccgcgc cgctgtcgac ggaatcgggg tagttcaccg
    18121 cgctcgacgc cgtcccggag gcgcagacga catacccggc cttgatgtcg gcgagcttgc
    18181 gggcactggt gatgtactcg tcgaccgagg tggcctgcgc gccgcacggg gtgtcaccgt
    18241 tgctgtccat accgccgttg cggcagtact tcagcacgcg gttgcggccg gtctggcctt
    18301 cgagccactg cgtcgccgcc gcgtcgttca cgtacggcag ggccgcgtag tcgtacgggt
    18361 acgagctctt ctcgatcccg tgctgctgca gcacgtcgtt gccgttgtgc tgcgtcggcg
    18421 tgttgttggt cttggtccgc atgcagtgcc cagccgtgag cacccagccc ttgccgggga
    18481 aaccaccacc ggtggaccgc aggttgaagc cgctggtgca accaccccag gtgccgttgt
    18541 cgcgcttcat gtccagccgg aggccgccgc gcatcgggcc gtagttcgtg cagtagagcg
    18601 gatgacagaa acccaggtcc acgttcgccg tggacagcgc gttcgggttc ttcagcacgc
    18661 gtgagacgac catgccggat tccgccgccg cggcctggtg cgcggcgttc gtctcggcgg
    18721 ccgcggcccg cacggccgcc ttctcctgcg ccacccagcc gcgttcccaa agcacgacac
    18781 ggttttcgga ctcgctcacc gaaggcaggt acaccgcgtc cgggccggcg ccgaccttgg
    18841 ccgcgacgcg ttccctcgcc gccgtcagct gctgcaacga gtgctggacc tgttgcgtgc
    18901 gaacggcgga gcgggcgggc atcgccctca gatacggctc ggccgccgag ggcttggtca
    18961 tcgccacgac cagttgcccc ttgtcctggt cgagccacat gccgccgtac tccgcgccgc
    19021 ggtcgcggcg gagcagttcg tccagtttca ggctgtcggt ctggagttcc agacgccgca
    19081 acgcctcctg ctcgctcact cggtagttct cgaccagata gcgcatcgac tcccgcaccg
    19141 aagcggggtc gagcgaggtg tggaacgact gcacggtttc ggccgtcgcc ggactgccca
    19201 gtgccatggt cgctgccagc accgaagcgg ccagcgcccc cagtcttcta gctctccgca
    19261 cgagatctcc tcacatgtcg gcgttcgcga tcattcaacc ggacgccgcc gcgtgcgtgg
    19321 ggagattttc cgacattgcc gggcgccccg tgcccgtgat gcggcgggca cggggcgcga
    19381 ttcgctacag actcggctct cgccgctgtt ttccttggcg ggacttgacg atccaggcgc
    19441 agaagagcgt caggagaccc acactggtcc ccgccgaaac cccgatttgc gggctgctga
    19501 tcctgacgac gccgacgacg attccgccac cgagcgtcag caggagacac atccgcaggg
    19561 tcggggccca gccggcgagg actgccatcg ccaggcagag ccagccatcg cgcgccggct
    19621 ccttgcgatg gcgtcccggt gtcctcagga gcggccgcgc cgtgcggatc atctccgcgg
    19681 acgtcgcgac tcgccgaacc ggcttttcgg cgtgttcgat gacgactttg acccgttggg
    19741 gcggctcgtt gtctggtgtc ttcgtgttgt cgggctgtaa ggtcacgacc gtcctgtcct
    19801 tgttctagcg agcgggcgaa tggacatccg cgtggcctcc tgtgacagca gggggccacg
    19861 cgtgcgttac cggttcttga ccggtgcggc tgaggacatc ttggcgaaag cagactgtga
    19921 ccgttcagta gtactgcgtg tgtctcgatg aacggtatgc acgcgtcgct caacggtctg
    19981 ggtgaccacg aaaactacta aaagtagtgg gtgggaccga atggaccagt gccgccggca
    20041 ggcctccgcg gcccggcatc ttgccttccc ggtgtcatcg ggggcatttg cggcggcagg
    20101 gaagtccgca ggtggaggcc gacgtcgatg tgttcgcgcg tcgcgttctc gcattgtgcg
    20161 aaatgctgat cgcaactgcc gagtacagtc gaacttcgcc caacgtcgac aagattcgag
    20221 catccgtgct cacggtgggt tcactcgaac aggcgggtgt ccgcccgtag tcgcctcgct
    20281 cggctcacca acagcgagtg actgctcaac cgagcaggag gagcgcgtag taggcgagga
    20341 agtgttcgac catgtaggcg ccgccggcgg tctgcgcgag cgaagcgtgg gtatgagcgt
    20401 gtgtgctttt gaggatggca gggatccggt cgtcctggtc ggggagtgcg gccgcgatgc
    20461 ggtgccagca ccacgcccgg tgcaggttga ggccgtgcag atgggcgagt tgtccgtcgg
    20521 aggtgtccgt cacggtcgcc ggggtgaaga ggggcgtggg tttccgttcc gcgatgccag
    20581 gaaggaaagc gtccagccaa tccgccaact cggccgcggg catcaggcgg gagatgagct
    20641 ccgcctcggc gagggcgggg gacaggaagt cggctcctga cggttcccag gatccggggt
    20701 aatcgcggtc ggatccgaac cagcgccaag ccgtctcgac gatgaggcgg tgcagccgcg
    20761 ggtcgccgtg gtcggcgagg tactccgcgt acggaagagc gcgggacaac ccgaacgcgc
    20821 cgttgtcatg caccccgtac cgaatcgggt aggtggcatg gggaagccag tcgaggtagc
    20881 ggttcacgaa gaccgcgctc agctgatgca atcccgctga ccagcgcgtg gcgtccgggt
    20941 cgtcccaggt ggcgacttcg caggtgagtt ccagcagtgc cgaccagccg tacgggcgct
    21001 gggtgttccg ctgctcctca ggggcgaagt aggagatctc gcctgagagc gcttcggcgg
    21061 tcaggtgctc gccgagaagg ccgcggatct cgtcggcggg cacgagttcg tggtgatgac
    21121 ggagcaaacg c
//
