LOCUS       NZ_CP102415            22877 bp    DNA     circular CON 26-AUG-2024
DEFINITION  Amycolatopsis roodepoortensis strain ZEL-1 chromosome, complete
            genome.
ACCESSION   NZ_CP102415
VERSION     NZ_CP102415.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis roodepoortensis
  ORGANISM  Amycolatopsis roodepoortensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Biodegradation of petroleum hydrocarbons by Amycolatopsis orientalis
            ZEL-1, genome analysis and its potential in plant protection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9489959)
  AUTHORS   Gao,T., Li,J., Ni,W., Xiong,S., Qiu,H., Li,W., Xia,W., Tao,X.,
            He,X., Yong,B., Wu,B. and Shao,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2022) College of Life Sciences, Sichuan Normal
            University, No. 1819, Section 2, Chenglong Avenue, Longquan
            District, Chengdu 610101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024628825.1-RS_2024_08_26
            Annotation Date                   :: 08/26/2024 06:13:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,064
            CDSs (total)                      :: 8,994
            Genes (coding)                    :: 8,928
            CDSs (with protein)               :: 8,928
            Genes (RNA)                       :: 70
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 27 of 66
            Pseudo Genes (incomplete)         :: 44 of 66
            Pseudo Genes (internal stop)      :: 4 of 66
            Pseudo Genes (multiple problems)  :: 9 of 66
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:48:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 21690
            Orig. end                         :: 44567
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102415.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22877
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22877
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22877
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12877](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12877)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(533..548)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.38"
                     /tool="antismash"
     misc_feature    840..854
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            1475..2782
                     /locus_tag="NQK81_RS00115"
                     /old_locus_tag="NQK81_00115"
     CDS             1475..2782
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334473.1"
                     /locus_tag="NQK81_RS00115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00115"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_257486446.1"
                     /sec_met_domain="Aldedh (E-value: 2.8e-79, bitscore: 265.8,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISTDAQAVVEELRDLFRSGVTKPVEWRRTQLAGLKRLLSEQADV
                     FVEALYADLRKNAVEAKRAEIALVRNEIDHTLENLDAWLTPEPAGLPNPLRPGEGRVVR
                     EPLGVALIIGPWNYPLQLVLAPLVGALAAGNCAVVKPSELSPNTSAAIAEHLPAYVEGV
                     RVVEGAIPETTALLEQKFDTIFYTGNGTVGRIVMAAAAKHLTPVTLELGGKSPAIVEPG
                     ADLAVTAQRLAYGKFANAGQTCVAPDYVLAIGDTGPKLAEHLAETIRAMFGEDPATSDS
                     YGRIISTRHHDRLAALLGDGTVVVGGQADRDEKYIAPTVLTGVSPDAPVMRDEIFGPIL
                     PIIDVPDVDAALAFVNERDKPLALYAFTESEETKRRIETETSSGGLVFGAAIIHLAAPE
                     LPFGGVGESGMGRYHGRYSIDNFSHVKAVLDKPLAG"
     gene            complement(2784..3464)
                     /locus_tag="NQK81_RS00120"
                     /old_locus_tag="NQK81_00120"
     CDS             complement(2784..3464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029571.1"
                     /locus_tag="NQK81_RS00120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00120"
                     /product="hypothetical protein"
                     /protein_id="WP_257486447.1"
                     /transl_table=11
                     /translation="MAEDDTSQAGPAGRLFRAGFHALAALRGARAFHPNGLLLNGELQA
                     LRRDELALPEEPVAVTVRMSKGAGLPGRVPDALGLAVRIPAVGGHPWDLTLTTSGTGLV
                     GRVLPRPARAWTTGRYSTLLPYRTKGELVWLSARAETSRHAEASLDGLRRLVAEGPVTF
                     LFETVRANGHRNPCARLTLDDVDDDSPRPAIDPMLNPPPGWEPRPGWISGLRERAYEGS
                     RAGR"
     misc_feature    complement(3327..3329)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(3504..3608)
                     /gene="allorf_0025194_0025298"
                     /locus_tag="allorf_0025194_0025298"
                     /protein_id="allorf_0025194_0025298"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGEQHASTRGKARHTGKRGFSIPCEFPCNPACPG"
     CDS_motif       complement(3579..3608)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGEQHASTRG"
                     /locus_tag="allorf_0025194_0025298_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(3504..3578)
                     /prepeptide="core"
                     /locus_tag="allorf_0025194_0025298_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="2553.9"
                     /monoisotopic_mass="2552.2"
                     /core_sequence="KARHTGKRGFSIPCEFPCNPACPG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGEQHASTRG"
                     /leader_location="[3578:3608](-)"
     gene            3651..4106
                     /locus_tag="NQK81_RS00125"
                     /old_locus_tag="NQK81_00125"
     CDS             3651..4106
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225123.1"
                     /locus_tag="NQK81_RS00125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00125"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_126735138.1"
                     /transl_table=11
                     /translation="MTASPATVRRAPRQLIALGVGAVFLLVGILGFIPGVTTNYDQLSG
                     AGHESGALLLGVFQVSILHNIVHLAFGVAGILLARTVSGAKAFLVGGGVIYLVLWLYGL
                     LIDHGSAANFVPVNTADNWLHLGLAVGMIALGLIPLSGSKAPIADSR"
     misc_feature    complement(3694..3709)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.68"
                     /tool="antismash"
     misc_feature    complement(4121..4135)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.2"
                     /tool="antismash"
     gene            4140..5021
                     /locus_tag="NQK81_RS00130"
                     /old_locus_tag="NQK81_00130"
     CDS             4140..5021
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334470.1"
                     /locus_tag="NQK81_RS00130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00130"
                     /product="manganese catalase family protein"
                     /protein_id="WP_034318613.1"
                     /transl_table=11
                     /translation="MFRHTKSLQFEAKPEKPDALYARKLQELIGGAYGEMTVTMQYLFQ
                     GWNCRIEGKYKDLIMDTATEEIGHVEMLATMVARLLEGAPATMVAEAAKDPATAAILGG
                     MDPQQAIISGGGATPSDSQGYPWNGRYVVASGNLLADFRANAAAEAQGRLQTARLYNMT
                     DDPGVKAMLQFNLARDTVHQKQWLAAIEELKADGLESDIAPTALFDEENQEHNNTIWHL
                     SDGPDGSKGGWSFGEDGIEYLMEPEPLGGPGTAPKPDPALYGTYAPLQDAVGTVKGKVK
                     DAKKKATKSSKS"
     CDS             5054..5203
                     /gene="allorf_0026744_0026893"
                     /locus_tag="allorf_0026744_0026893"
                     /protein_id="allorf_0026744_0026893"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGRSPSPVWETALPQGRGRFLDCPQGTVRGLAISDMGALRGGREW
                     QCSF"
     CDS_motif       5054..5179
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MGRSPSPVWETALPQGRGRFLDCPQGTVRGLAISDMGALRGG"
                     /locus_tag="allorf_0026744_0026893_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5180..5203
                     /prepeptide="core"
                     /locus_tag="allorf_0026744_0026893_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="953.0"
                     /monoisotopic_mass="952.4"
                     /core_sequence="REWQCSF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGRSPSPVWETALPQGRGRFLDCPQGTVRGLAISDMGALRG
                     G"
                     /leader_location="[5053:5179](+)"
     gene            complement(5317..6303)
                     /locus_tag="NQK81_RS00135"
                     /old_locus_tag="NQK81_00135"
     CDS             complement(5317..6303)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226134.1"
                     /locus_tag="NQK81_RS00135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00135"
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="WP_257486448.1"
                     /transl_table=11
                     /translation="MAATAKDPDGPTELSRRSWWAVLKRTFVQFNRDNMLDWAAALTYY
                     GVLSLFPGLLVLTAILGLMGPSATQALVENVGRIAPGQGRDILIGAIEELSKTGGLAGT
                     AAIIGSAGALWSASGYIGAFMRASNVIYSMPEGRPIWKTVPLRIGLTIAVLIVLALCAA
                     GVVATGGIARHLGDLIGLGSTGVLVWDIVKWPVIALLAGLAFAMLYWVSPNVRQPKFRW
                     LTPGGLVAVLLWAAATAGFAFYVSNFGSYNKVYGSLAGVIVFLIWLWISNIAVLLGAEL
                     DAELARGKEQASGYLADDEPFLPPRDTAAMDDDEAAAVAEAETKNAD"
     gene            complement(6364..6576)
                     /locus_tag="NQK81_RS00140"
                     /old_locus_tag="NQK81_00140"
     CDS             complement(6364..6576)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029577.1"
                     /locus_tag="NQK81_RS00140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00140"
                     /product="ferrous iron transport protein A"
                     /protein_id="WP_257486449.1"
                     /transl_table=11
                     /translation="MTLPDVPLGTRVVVRYRIEGGFTDALGYLRSRDDTECTVETKRGL
                     ATIRLADIVLAKTVPPPPPPRPRPA"
     gene            complement(6573..6812)
                     /locus_tag="NQK81_RS00145"
                     /old_locus_tag="NQK81_00145"
     CDS             complement(6573..6812)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334468.1"
                     /locus_tag="NQK81_RS00145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00145"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_126733136.1"
                     /transl_table=11
                     /translation="MSDLIVYGAGWCPDVKRSRALLDSKGIEYDYVDVEADSGAEETVR
                     ALQNGERRIPTIVWPDGTHLVEPSDDELTAHLNR"
     CDS_motif       complement(6786..6812)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSDLIVYGA"
                     /locus_tag="NQK81_RS00145_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6573..6785)
                     /prepeptide="core"
                     /locus_tag="NQK81_RS00145_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="7735.4"
                     /monoisotopic_mass="7730.9"
                     /core_sequence="GWCPDVKRSRALLDSKGIEYDYVDVEADSGAEETVRALQNGER
                     RIPTIVWPDGTHLVEPSDDELTAHLNR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDLIVYGA"
                     /leader_location="[6785:6812](-)"
                     /alternative_weights="7753.4"
                     /alternative_weights="7771.4"
                     /alternative_weights="7789.4"
                     /alternative_weights="7807.4"
                     /alternative_weights="7825.5"
                     /alternative_weights="7843.5"
                     /alternative_weights="7861.5"
     gene            complement(6816..9704)
                     /locus_tag="NQK81_RS00150"
                     /old_locus_tag="NQK81_00150"
     CDS             complement(6816..9704)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029579.1"
                     /locus_tag="NQK81_RS00150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00150"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257486450.1"
                     /transl_table=11
                     /translation="MGIRSSRVIGRDAELAELSGALDRAIAGRGGAIFLVGEGGIGKSR
                     LAIEAAARAVSAEIPVLQGRAGSIGPLVPFRPLAQALWSHFRGGGPPSAAELDPFVPVL
                     AQLIPDWGRGDRPRESGSLLVLAEAVFRLLAVTSRDRGALLVLDDLQDADAETLFILEY
                     LVDNLSSAHVLFVGTLRNEPSDALRLATSGAQRMSCAVVELGRLGLADTRALAAACLET
                     EPERLPSAAADLLWRNSAGLPFIVEELLHGMVNDGLLVEGPDGWRVIGELRARVPAALV
                     TSIGVRMEQLGEQAGELLSVAAIIGRRFPLTVVQTVTGTNDRTLHNHLSAAVSANLVTT
                     DGTTPGWYAFRHPLTAEALLARQSPARKAALARQAADAVEKLYPGLPGDLCALVASLRL
                     TALDEQAAGRLFAETGRRALDAGAADSAVTMLTKAVDLLAGADAGDRAEVLETLVHALG
                     QTGQFDRAVELSAGFGEIGTLERAAKLHTQLAWAAYIAGRHDECLAQIERARAPLGSAI
                     SPAQRAALDAVEANLWLDVPGRADTAERLARQAWKVAEATEQPFVVCQALQVLGMLALS
                     RDLTESEHYMQLARRTAEDNHLHHLRTQALVRLGGHRVLMNGDEQTLLLARADAQRTGS
                     ITLHCAVDSVRTMHAILRCEFGTAHALLAENLAVLGRLRLTALLQYAHMTRAMSAGHRA
                     DRPAMEQALDDFRESGGENAQEMVLSIGLARVFCSLLEEDFDRARRELGQVVELEDRRP
                     SRFHLAGRHGLRTLVETLHGAPCPEDGSAVSGMRWNRQFVEFAHAVEHGRRGDAVAAGQ
                     AVASALETSAPYPLARHLGLRLIAEPAAADGWGDPAGWLKEAEEYFHRREIPAVAAACR
                     TLLRKLGAPVRQRRSGVDRVPVDLRASGVTVREYEVLVLLAERMGNKDIGARLHISPRT
                     VEKHVASLLAKTGLADRAALAERAAGPRPGML"
     gene            complement(9794..9988)
                     /locus_tag="NQK81_RS00155"
                     /old_locus_tag="NQK81_00155"
     CDS             complement(9794..9988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029580.1"
                     /locus_tag="NQK81_RS00155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00155"
                     /product="hypothetical protein"
                     /protein_id="WP_192742314.1"
                     /transl_table=11
                     /translation="MYDRELPATEDVLGAVNLPRALEVGSRNHALAGGKPRLSANPLAT
                     LSTDPGSPSVVSVFTGGWI"
     gene            complement(10001..12877)
                     /locus_tag="NQK81_RS00160"
                     /old_locus_tag="NQK81_00160"
     CDS             complement(10001..12877)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635680.1"
                     /locus_tag="NQK81_RS00160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00160"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_257486451.1"
                     /sec_met_domain="DUF4135 (E-value: 4.3e-97, bitscore:
                     324.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.2e-13, bitscore:
                     47.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVTPRPSAPSLPPRWWVPGQTPRERTADKPTWADFAEHAVTAL
                     LPERPPAGDWRVDFAGVFRPLVHAASRDAVPDDLPGADVEALRRGFAAQLDQHLLKLAV
                     RTLVLELHRDRKAGHLRGETPEERFSDFVRRQATPAGLVRLFGEYPVLARLVAQACLHA
                     VEAHAETLARFSADAALLPCSVVDGELGALVEVAGGIGDSHARGRSVKLLRFSSGAKVI
                     YKPRPLILHERFTDVVTLLNKRLPGLELRTADALPRAGYGWLRFVEHRPCADIGDVDRF
                     YRRQGILLALLYSLDATDVHYENIIACGDQPVLIDIETLFQPSPPDPPEGDPAAAMLAR
                     SVQRTLLLPQLFAGEHGAVDISGLAGRGGKLPTDRVDWADPGTDRMRLVRVPGELSGGN
                     NLPRLDGRDVTPAEHSAALLAGFRLGYDAISSARDELAEHLRRCAEDPIRVLIRPTNFY
                     FRLLDETTHPDLLRDAADRDRAFDLLEEDSADEEKLLRLVPHERDDLWAGDVPMFTSNP
                     GSTSLVDSRAENVEGVVERPSLDTVLAKLADMDPLDQRDQEWLISATLAISTATVGHLG
                     GETAETAAPNQAPDAERLLVTACGIADQIVANAFSDEHRSNWLGIELVDDRYWTVLPMG
                     AGLGEGYCGVALFLAQLAELTGIARYRDLAAYAISPLPGLFATLRADRELAATAGCGGL
                     LGLGGVAYTIARLSTLVGLPAGDLIEQAVDLMPDATPETPSGFTTGLAGGVASMRSVYV
                     QTGLDTALTRADRYAGELLGRERPREKSFARGSAGIDWVLRAHDRSGEEPPGRADDRAE
                     STGGWCGGLAGDALGLAAHLADPGHARDLDRTIKRLADGAPLKDLSLCHGESGVLDVLC
                     VLAENGHTGAAAAVRRRTGHLLAAIDQRGARCGTPGAVPSPGLLSGLAGIGYGLLRLGF
                     GDRVPSALLLRPDRPHPAASVVPPVNRV"
     misc_feature    complement(11495..11497)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12976..12990
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.63"
                     /tool="antismash"
     CDS             complement(13291..13404)
                     /gene="allorf_0034981_0035094"
                     /locus_tag="allorf_0034981_0035094"
                     /protein_id="allorf_0034981_0035094"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVKIFDRSSREHNRTRNPIQGAPQCRCSPSTCTTATT"
     CDS_motif       complement(13339..13404)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVKIFDRSSREHNRTRNPIQGA"
                     /locus_tag="allorf_0034981_0035094_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13291..13338)
                     /prepeptide="core"
                     /locus_tag="allorf_0034981_0035094_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.40"
                     /molecular_weight="1446.6"
                     /monoisotopic_mass="1445.6"
                     /core_sequence="PQCRCSPSTCTTATT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVKIFDRSSREHNRTRNPIQGA"
                     /leader_location="[13338:13404](-)"
                     /alternative_weights="1464.6"
                     /alternative_weights="1482.6"
                     /alternative_weights="1500.7"
                     /alternative_weights="1518.7"
     misc_feature    complement(13417..13426)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     misc_feature    complement(13419..13433)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.62"
                     /tool="antismash"
     misc_feature    complement(13420..13431)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.36"
                     /tool="antismash"
     CDS             13665..13889
                     /gene="allorf_0035355_0035579"
                     /locus_tag="allorf_0035355_0035579"
                     /protein_id="allorf_0035355_0035579"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSDSRKEDAPLGCGTVIAHLPTESGFPVFRRTIATVAIELATAFG
                     GASRRIRPQPTPSPRPGAVIRGLPARPCT"
     CDS_motif       13665..13802
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSDSRKEDAPLGCGTVIAHLPTESGFPVFRRTIATVAIELATAFGG"
                     /locus_tag="allorf_0035355_0035579_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13803..13889
                     /prepeptide="core"
                     /locus_tag="allorf_0035355_0035579_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.50"
                     /molecular_weight="2952.4"
                     /monoisotopic_mass="2950.7"
                     /core_sequence="ASRRIRPQPTPSPRPGAVIRGLPARPCT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDSRKEDAPLGCGTVIAHLPTESGFPVFRRTIATVAIELA
                     TAFGG"
                     /leader_location="[13664:13802](+)"
                     /alternative_weights="2970.5"
                     /alternative_weights="2988.5"
                     /alternative_weights="3006.5"
     misc_feature    complement(13749..13762)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.33"
                     /tool="antismash"
     gene            13886..14188
                     /locus_tag="NQK81_RS00165"
                     /old_locus_tag="NQK81_00165"
     CDS             13886..14188
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS00165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_00165"
                     /product="hypothetical protein"
                     /protein_id="WP_257486452.1"
                     /transl_table=11
                     /translation="MTITAPATVKRNVEAAVFVKVDGVEPWPNSELSAASAWLVGFLRQ
                     GGAGTGEVKIDSLKNPATIPNGGHFSVEGTQQVTFSTPGTGTLGLHRFGRPLTYW"
     gene            complement(14297..14527)
                     /locus_tag="NQK81_RS00170"
                     /old_locus_tag="NQK81_00170"
     CDS             complement(14297..14527)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NQK81_RS00170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NQK81_00170"
                     /product="hypothetical protein"
                     /protein_id="WP_126733130.1"
                     /transl_table=11
                     /translation="MKKKIAATAAVLGALASTIAFAQPAGAGVDPRYYYESSWSTEGDC
                     RINGHSGQQAGRWSAYFCSASTWTWDLYIKR"
     CDS_motif       complement(14486..14527)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKKIAATAAVLGA"
                     /locus_tag="NQK81_RS00170_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14297..14485)
                     /prepeptide="core"
                     /locus_tag="NQK81_RS00170_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.20"
                     /molecular_weight="6742.3"
                     /monoisotopic_mass="6738.2"
                     /core_sequence="LASTIAFAQPAGAGVDPRYYYESSWSTEGDCRINGHSGQQAGR
                     WSAYFCSASTWTWDLYIKR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKKIAATAAVLGA"
                     /leader_location="[14485:14527](-)"
                     /alternative_weights="6760.3"
                     /alternative_weights="6778.3"
                     /alternative_weights="6796.3"
                     /alternative_weights="6814.3"
                     /alternative_weights="6832.4"
                     /alternative_weights="6850.4"
                     /alternative_weights="6868.4"
                     /alternative_weights="6886.4"
                     /alternative_weights="6904.4"
                     /alternative_weights="6922.5"
     gene            complement(14675..16198)
                     /locus_tag="NQK81_RS00175"
                     /old_locus_tag="NQK81_00175"
                     /pseudo=""
     CDS             complement(14675..16198)
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013628.5"
                     /locus_tag="NQK81_RS00175"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00175"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVRTVIASTATSTNCVLTLSHLPDSAAGKDNQAGSARAQTTSTPL
                     DRTTRRIRCAQARNRGGLPFVTNSEVLVPWRDATAAHQPEWPDRAALREVLARLSAAPG
                     LVTPRACDDLRHRLAEVASGRAFALQGGDCAETFDGATPRAIQAKTKTLLQMAVVLTHA
                     AAMPIVKIGRMAGQYAKPRSSSTETRDGLALPVYRGDAVNGYPFDAAARRPDPARLWRM
                     YEASRSTLDIVDGYARNGYASLDQLHRWNRDFVANSPSGARYEEVAYEIDRALRFMRAC
                     GAQPEELRSAEIFASHEGLLLDYEDTLTRTDHSTGRDYATSGHMLWIGERTRALDGAHV
                     AYFRSIANPIGVKLGPTTTPAEVRSYVDILDPDREPGRLTFITRMGARQIRDRLPTLIR
                     AAQAVGGVSV"
     misc_feature    complement(15374..15376)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16104..16118
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.44"
                     /tool="antismash"
     gene            16146..17594
                     /locus_tag="NQK81_RS00180"
                     /old_locus_tag="NQK81_00180"
     CDS             16146..17594
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012640.5"
                     /locus_tag="NQK81_RS00180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00180"
                     /product="anthranilate synthase component I family protein"
                     /protein_id="WP_257486453.1"
                     /transl_table=11
                     /translation="MRTQFVDVAVDAITVRTTASALAVRNELCRRFGAEDVYLLEDLHP
                     GNLDSSRSTGTVVGFGRLVEISVLGDEVTVRGDGRVADLVRVLCGRPAANVWETLREVT
                     GSFRVRTEVPGFAFGFLTTVGYDAAALMEELPPRRGGPDVPDLTLTLFQHTVWFDREDV
                     PPVLHVATGPDLPESSPQDVLRNIPGADGPMPEATKPRSVRDSVEKDTFLGWVERCLEH
                     IRVGDIYQIQVGHRIDVHSDLTPEDVYRRLRHRNPSPYMYLITQSGRTLVGASPEVLFR
                     VDDDARITMRPIAGTTRRDPAGSDNERRIKELVASTKEQAEHVMLVDLCRNDVGRVCRP
                     GTLSVDDLMAVEAFSHVFHLVSTVTGTMAGGHDVWDVLCATFPAGTMTGAPKLRAMEII
                     DEIEVERRGVYAGAVGLVDLRGWAELALCIRTITHHEPSPGDHRYSTQSCAGVVALSEP
                     EREWDETLAKMGATYWALTGEEPA"
     gene            17591..18175
                     /locus_tag="NQK81_RS00185"
                     /old_locus_tag="NQK81_00185"
     CDS             17591..18175
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010695511.1"
                     /locus_tag="NQK81_RS00185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00185"
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="WP_257486454.1"
                     /transl_table=11
                     /translation="MKVLVVDVFDSFVHIIDQYLRQLGADTAVVRSGTRTPEELAATRP
                     DAVVLGPGPGHPADSGHVDLVRRFAGEVPLLGVCLGHQAIALAFGGAVRLADNLMHGRT
                     SVIEHDGRGVYTGLPERHEVTRYHSIVVAEPLPGDLVRTARSLDDGYVMGMRHRELPIE
                     GVQFHPESVATVDGTRMMANFLAAVTTRADR"
     gene            complement(18153..19538)
                     /locus_tag="NQK81_RS00190"
                     /old_locus_tag="NQK81_00190"
     CDS             complement(18153..19538)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (135-413). E-value:
                     1.3e-08. Score: 26.3. Matches aSDomain:
                     nrpspksdomains_NQK81_RS00190_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010695510.1"
                     /locus_tag="NQK81_RS00190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00190"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_257486455.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.9e-06, bitscore:
                     26.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPITIDRDSPLSLTAQVESAIRERITDSTLHQGVRLPSSRTLAA
                     DLGVSRGVVVQAYEQLIAEGYLRATQGSGTQVATHLPRLGTAGARRPSELVDVRFDLRV
                     DATSTAFFPEREWLHAYRHMARSIGGTGPRRHPLGVAELRTELAAYLGRSRGVLTGASE
                     VVVAADFAHVFEGLCHALHDLGAGHIAVENPGTPWLAGIAERAGLRVTGVPVDREGIDV
                     EALARSGARAVLITPVSQVPTGVMLSASRRKELLRWADQVDGWVVEHDRDGDLWFGAGS
                     GPLALQRHRTHRVIYAGSTRGLLGPGLRLGWSVVPGVVAKRLSQAQLGAPDALTQLAFA
                     HFVSSGLLDQHIRQIRGTCRARRAALGDAIEEHLPGARMTGVPAGTHAYVALPAGIDDG
                     RVSAEARRRSALVQPVRYFQLDRRPASSGLVLGYGAVRRGRLADSVKLLASVMDEVSGL
                     LAS"
     aSDomain        complement(18300..19133)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NQK81_RS00190_Aminotran_1_2.1"
                     /evalue="1.30E-08"
                     /label="NQK81_RS00190_Aminotran_1_2.1"
                     /locus_tag="NQK81_RS00190"
                     /protein_end="413"
                     /protein_start="135"
                     /score="26.3"
                     /tool="antismash"
                     /translation="HPLGVAELRTELAAYLGRSRGVLTGASEVVVAADFAHVFEGLCHA
                     LHDLGAGHIAVENPGTPWLAGIAERAGLRVTGVPVDREGIDVEALARSGARAVLITPVS
                     QVPTGVMLSASRRKELLRWADQVDGWVVEHDRDGDLWFGAGSGPLALQRHRTHRVIYAG
                     STRGLLGPGLRLGWSVVPGVVAKRLSQAQLGAPDALTQLAFAHFVSSGLLDQHIRQIRG
                     TCRARRAALGDAIEEHLPGARMTGVPAGTHAYVALPAGIDDGRVSAEARRRSALVQ"
     gene            19646..20713
                     /gene="trpD"
                     /locus_tag="NQK81_RS00195"
                     /old_locus_tag="NQK81_00195"
     CDS             19646..20713
                     /EC_number="2.4.2.18"
                     /GO_function="GO:0004048 - anthranilate
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873429.1"
                     /locus_tag="NQK81_RS00195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00195"
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="WP_257486456.1"
                     /transl_table=11
                     /translation="MAGGETTIETDRKRWAEILSALTQGYDLTAEDTEWALGEVMRGAA
                     GEARLSGLLIGLRSKGETAQELDGLVRAMDAHAVRIAVDGPLLDIVGTGGDQAGTVNIS
                     TMSAIVAAAAGARIVKHGNRSASSQCGSADLLEALGVVIDLPAATVRQVLSEVGIAFCF
                     APVFHPAMRHASQVRRQLGVPTVFNVLGPLTNPAAPAASAIGVAEARMAPIVAEVLSRR
                     GRSALVFRGDDGLDELTVTTTSQVWTVYDGTVRQETFDPRDLGIPLVSPDRLRGGGPAR
                     NAEITLDFLDGATGPVRDAVLLSAAAGLAATAPGTAPITERLGVCFEKAASAVDSGDAG
                     ALLGQWVRVTGKLAE"
     gene            complement(20721..21530)
                     /gene="trpC"
                     /locus_tag="NQK81_RS00200"
                     /old_locus_tag="NQK81_00200"
     CDS             complement(20721..21530)
                     /EC_number="4.1.1.48"
                     /GO_function="GO:0004425 - indole-3-glycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948075.1"
                     /locus_tag="NQK81_RS00200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00200"
                     /product="indole-3-glycerol phosphate synthase TrpC"
                     /protein_id="WP_257486457.1"
                     /transl_table=11
                     /translation="MNVLAEIVAGVRTDLPVRMAEVSPAVLRRRAEARGPRMTPDAVGA
                     ALRGTHGVRLIAEVKRVSPAMGRLAAIERPEALAAEYVAGGAAAISVLTEPRHFGGSLD
                     DLRAVRDSVSVPLLRKDFIVDPYQLAESAAAGADLVLLIVAALSGRQLDGLLKEAAEYG
                     LAVLVETHTEQEVATAVAAGARIIGVNARNLTTLQVDRDTFPRLAAGIPADVVTVAESG
                     VRGPADVGSYAGAGADAVLVGSALVIDDRPADAVAAMLAAGRREEVE"
     gene            complement(21552..22733)
                     /locus_tag="NQK81_RS00205"
                     /old_locus_tag="NQK81_00205"
     CDS             complement(21552..22733)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="NQK81_RS00205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQK81_00205"
                     /product="cytochrome P450"
                     /protein_id="WP_257486458.1"
                     /sec_met_domain="p450 (E-value: 6.3e-17, bitscore: 60.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTSSKPTRDLLFPDLSDSIEERIAWFQHQHRVEPLRHRPEYNL
                     WEVFRYEDVQRVLKDPDTFSVTNKTHMGLPFSFGRADIQEHRFLRSFVARSFVPGNIEA
                     HASDFAPMVDALLKPALASGRLEVLGDLGYPLMEHVIGHLFGLQIPGPDRFRQWSDQMF
                     GQLVGIFQPDHAEVVGMLTDQLDQRKRKPTGDLMSALLQARAKDDRLPEEKIIHMCLDL
                     VTAGNAPTSLLLSYMFARFCRNPEFYQALRSDPSLIPGAIEEVLRFDFSWFNLWRTARH
                     DTELGGREIKAGSYIVVWDSAANFDETRFPQAHRFDITRSPNPHLTFGQGMYICLGLPL
                     VRTLGRVVVERVVETFEEIRFDPERPMRSQEQMIDYVVSLDTLVSPANTTVSR"
ORIGIN
        1 gtcccgagca gcggatcgac ccgctgggcc gtcgcgcagg ccgccccgtt ccggcggatg
       61 gacatccgtg gcgggctcca gctctacccg gccagctacg ggttcgccag cggtggctac
      121 accgccgaca gcaaggtgtc cgggcagacc gcgtcgatct cgcagcagca gtggtacacc
      181 cgggacagca gctacggcag ctgggacggc ggggtctgga acatggtctt ctcggggacg
      241 agtggcgcgc ccgccaacac cttcccgaac ccgccggaga cgacgctcgg caccacgccg
      301 gtgtcccgtg acgtcccgta tctgtacctc gacggctccg gcaaataccg cgtgttcctg
      361 ccttccttgc gcaccaacgc ttccgggccg agctgggcca acggcggcac cccgggcagc
      421 tcgctgccga tgagccagtt ctacgtggtg aaggcggggg acacggcggc gtcgatcaac
      481 accgcgctct cccagggctg caacctgttc ttcacgccgg gcgtctacca cctgaaccag
      541 acgctcaacg tgacgaaggc gaacaccgtc gtcctcggcg tcggctatcc gacgctggtg
      601 ccggacaacg gtgtcgacgc gatgaaggtc gccgacgtgg acggcgtccg gatcaagggc
      661 ctcctgttcg acgccgggac gaccaactcg cagtcgctgc tcacggtcgg gcaggcgggc
      721 tcgacggcga accactccgc gaacccgacc accctgcagg acgtgttctt ccggatcggc
      781 ggccagatcg ccgggaaggc gacgaacagc ctgatcgtca acagccgtga cacgatcatc
      841 gaccacatct gggcctggcg ggccgaccac ggcaacgcgg gcacctacgg ctggacgatc
      901 aacaccggtg acaccggcgt ggtcgtcaac ggcgacaacg tgctggccac cggcctgttc
      961 gtcgagcact accagaagta ccaggtgatc tggaacggcc agaacggcag gacgatcttc
     1021 ttccagaacg agatcccgta cgacgtcccg gatcaggccg gctggaagag tcccaacggg
     1081 ctcaacggat acgccgcgta caaggtgggg gacaacgtga cctcccatga ggcgtggggc
     1141 ctgggcagct actgcttctt caacgacaac ccgtcggtga acctgtatca cgcgttcgag
     1201 gtgccgaatc gctccggcgt ccggttccac aacatggtga cggtttcgtt gaactacaag
     1261 gggaccatca cgcacgtgat caacgacgcc ggggcggtga cgccaccgga cacgcggccg
     1321 agcaacctgg tgagctaccc gtagtgtccg tcccctgaag tacgtgaagg accccttcac
     1381 tgcgtctagc gcagtgaagg ggtccttcac gtttctcttc tgtataacgc cctataccga
     1441 gcggcgacaa gcgcccgagg ttaggctcag aaccatgatc agcacggatg cccaagccgt
     1501 cgtcgaagaa ctgcgcgacc tctttcgatc cggcgtcacg aagccggtgg agtggcggcg
     1561 gacgcagctc gcaggcctca agaggctcct gtccgagcag gccgacgtct tcgtcgaggc
     1621 gctctacgcc gatctgcgca agaacgccgt cgaggcgaaa cgggcggaga tcgcgctcgt
     1681 gcgcaacgag atcgaccata cgctggagaa cctcgacgcc tggctgaccc cggagcccgc
     1741 cggtctcccg aacccgctgc ggccgggcga aggccgcgtc gtacgcgagc cgctcggggt
     1801 cgcgctgatc atcgggccgt ggaactaccc gttgcagctg gtcctcgcgc cgctcgtcgg
     1861 ggcgttggcg gcggggaact gcgcggtcgt gaagccgagc gaactgtccc cgaacacctc
     1921 ggcggcgatc gcggagcatc tgccggccta cgtcgagggt gtccgggtcg tcgagggggc
     1981 gatccccgag acgacggcgc tgctggagca gaagttcgac accatcttct acaccgggaa
     2041 cggcacggtg ggccggatcg tcatggccgc ggcggcgaag catctcacgc cggtcacgct
     2101 ggaactgggt gggaagagcc cggcgatcgt cgagcctgga gccgatctcg cggtgaccgc
     2161 gcagcggctc gcgtacggca agttcgccaa cgcgggccag acctgcgtcg cgcccgacta
     2221 cgtcctcgcg atcggtgaca ccggcccgaa gctggctgag caccttgccg aaacgatccg
     2281 cgcgatgttc ggcgaggacc cggccaccag cgactcctac ggccggatca tctcgacccg
     2341 ccatcacgac cggctcgccg ccttgctggg cgacggaacg gtcgtcgtcg gcgggcaggc
     2401 cgaccgcgac gagaagtaca tcgcgcccac cgtgctcacc ggcgtctcac cggacgcccc
     2461 ggtgatgcgg gacgagatct tcggcccgat cctgccgatc atcgacgtcc ccgacgtcga
     2521 cgcggcgctg gcgttcgtca acgagcgcga caagccactg gcgttgtacg ccttcaccga
     2581 atcggaggag acgaagcgcc ggatcgagac ggagacgtcg tcgggcgggc tggtgttcgg
     2641 tgccgcgatc atccacctcg cggcgccgga actgccgttc ggcggggtgg gggagagcgg
     2701 gatgggccgt taccacgggc gctactcgat cgacaacttc agccatgtga aggccgtgct
     2761 ggacaagccg ctcgcggggt gaatcaccgg cctgcccggc tgccctcgta ggcgcgctca
     2821 cgtagtccgc tgatccagcc cggccgtggc tcccagccgg gcggtgggtt gagcatggga
     2881 tcgatggcgg gacgagggga gtcgtcgtcg acgtcgtcga gggtcagcct cgcgcagggg
     2941 ttccgatgcc cgttcgcgcg gacggtctcg aagaggaagg tcaccggccc ttcagcgacc
     3001 agccgcctca atccgtccag cgaggcttcg gcgtgccgtg acgtctccgc gcgggccgac
     3061 agccagacca gttcgccctt cgtgcggtag ggcagcaacg tgctgtagcg gccggtggtc
     3121 caggcgcgag caggcctcgg cagcacgcgg ccgacgaggc cggtgcccga agtggtcaac
     3181 gtgagatccc acggatggcc tccgacggcg gggatccgca ccgccagccc cagcgcgtca
     3241 ggcacgcgtc ccgggagacc ggcgcccttg gacatccgca cggtgacggc gaccggttcc
     3301 tccggcaggg cgagctcatc acgccgtaaa gcctgaagtt caccgttgag cagtagaccg
     3361 ttcgggtgga aggcccgggc gccgcgaagt gccgccaggg cgtgaaatcc ggcgcggaaa
     3421 agcctgccgg cgggcccggc ctgcgatgtg tcgtcctcgg ccacgatttc caccctcctg
     3481 atgacgtgtg tgctccgcag gggctacccc ggacaggccg ggttacacgg gaattcgcac
     3541 ggaatcgaaa acccccgttt cccggtgtga cgggctttcc cccgggtact cgcgtgctgt
     3601 tcgcccatcg ggcgtccgac agtcctgttc cacctggatc ggaggaaatc atgactgcat
     3661 cgccggccac ggttcggcgg gctccgcgcc agctcatcgc cctcggcgtg ggcgcggtct
     3721 tcctgctcgt cggcattctc ggcttcatcc ccggcgtcac cacgaactac gaccagctga
     3781 gcggtgccgg gcacgagtcc ggtgcgttgc tgctcggcgt gttccaggtg tcgatcctgc
     3841 acaacatcgt ccacctggcg ttcggcgtcg cgggcattct gctggcccgg acggtgagcg
     3901 gcgcgaaggc gttcctcgtc ggaggcgggg tgatctacct cgtgctctgg ctgtacgggc
     3961 tgctgatcga ccacgggtcg gcggcgaatt tcgtgccggt caacaccgcc gacaactggc
     4021 tgcacctcgg gctcgctgtc gggatgatcg cactcgggct cattccgctc tccggttcca
     4081 aggcgccgat cgccgactcg cgctgacccg ttctcccctc aattctctgg aggttttctg
     4141 tgttccgtca taccaaatcg ctccaattcg aggccaaacc ggaaaaaccg gacgctttgt
     4201 acgcccgtaa gctgcaggag ctcatcggtg gcgcctacgg tgaaatgacc gtcaccatgc
     4261 agtacctgtt ccagggctgg aattgccgga tcgagggtaa gtacaaggat ctgatcatgg
     4321 atacggcgac cgaggagatc ggtcacgtgg aaatgctcgc gacgatggtc gccaggctgc
     4381 tcgaaggcgc gcccgccacc atggtggccg aagccgcgaa ggatccggcc accgcggcca
     4441 tcctcggcgg gatggacccg cagcaggcga tcatctccgg tggcggcgcc acgccgagtg
     4501 acagccaggg ctacccctgg aacggccgct acgtcgtggc ctcgggcaat ctgctggccg
     4561 atttccgggc gaacgccgcg gcggaggcgc agggccgctt gcagacggcc cggttgtaca
     4621 acatgaccga cgaccccggt gtgaaggcga tgctgcagtt caacctcgcg cgggacacgg
     4681 tgcaccagaa gcagtggctc gccgcgatcg aggaactcaa ggccgacggc ctggaaagcg
     4741 acatcgcgcc gacggcgttg ttcgacgagg agaaccagga gcacaacaac accatctggc
     4801 atctgtccga cgggccggac ggttcgaagg gtggctggag cttcggcgaa gacggcatcg
     4861 agtacctgat ggagcccgag ccgctcggcg ggccgggcac cgctccgaag cccgaccccg
     4921 cgctttacgg cacctacgcg ccgctgcagg acgcggtcgg gacggtcaag ggcaaggtca
     4981 aggacgccaa gaagaaggcc accaagtcga gcaagagcta gcgctccgag gtgaagggct
     5041 cctccccgcg gctgtgggga ggagcccttc acctgtgtgg gagacggcct tgccacaggg
     5101 acgcgggcgc ttccttgact gtccacaggg gactgttcgg ggattggcga tatccgatat
     5161 gggtgcttta cgagggggtc gtgagtggca atgctcgttc taaccctctt tgccactcac
     5221 gactcctcga aaagtgtccc ttgcggacag tctgccaaag gcgtttcttt ggcggctctg
     5281 ctccttcggg ccagtcgagg atttccagtt cgtgtgtcag tcggcgttct tggtttcggc
     5341 ttcggcgacc gcggccgctt cgtcgtcgtc catcgccgcg gtgtcacgcg gcgggaggaa
     5401 gggctcgtcg tcggcgaggt atccggaggc ctgctctttg ccgcgcgcga gttcggcgtc
     5461 cagttcggcg ccgaggagga ccgcgatgtt cgagatccac agccagatca ggaacacgat
     5521 gacgccggcg agcgagccgt agaccttgtt gtaagacccg aagttgctga cgtagaaggc
     5581 gaacccggcg gtggccgcgg cccagagcag cacggccacg aggccgcccg gcgtcagcca
     5641 ccggaatttc ggctgccgca cgttggggct cacccagtag agcatcgcga acgcgagccc
     5701 cgccagcagc gcgatcaccg gccatttcac gatgtcccag acgaggacgc cggtcgagcc
     5761 gagaccgatc aggtcgccga ggtggcgggc gattccgccg gtcgccacca ccccggcggc
     5821 acacagggcg agcacgatca gcacggcgat ggtgagtccg atccgcaacg gcacggtctt
     5881 ccagatcggg cggccttcgg gcatcgagta gatgacgttg gacgcacgca tgaacgcgcc
     5941 gatgtagccg gatgcggacc acaacgcgcc cgcggagccg atgatcgccg cggttccggc
     6001 cagcccgccg gtcttggaca gctcttcgat ggcgccgatc aggatgtccc ggccctggcc
     6061 gggtgcgatc cggccgacgt tctcgaccag tgcctgggtg gccgacggac ccatcaggcc
     6121 gaggatcgcg gtcagcacga gcagaccggg gaagagcgag agcacgccgt agtaggtgag
     6181 cgccgccgcc cagtccagca tgttgtcgcg gttgaactgg acgaatgtcc gcttgagcac
     6241 ggcccaccac gatcgtcggg acaactcggt gggaccgtcc gggtctttcg ctgtggcagc
     6301 caagggaacc tcctgctggg gattccttgg cttacccggt ggcgccgggg cgaaaacggg
     6361 tgatcaggcc gggcgagggc gcggcggtgg tgggggcggg accgtcttcg ccagcacgat
     6421 gtcggccagc cggatggtgg cgagcccgcg tttggtctcc accgtgcatt ccgtgtcgtc
     6481 acgggaacgg aggtagccga gcgcgtcggt gaacccgccc tcgatccggt accgcacgac
     6541 gaccctcgtg ccgagcggga cgtccggcag ggtcaccggt tcaggtgggc ggtgagctcg
     6601 tcgtcgctcg gctcgaccag gtgggtgccg tccggccaga cgatcgtcgg gatccgccgt
     6661 tcaccgttct gcagcgcccg cacggtctcc tccgcgccgg aatccgcctc gacgtcgacg
     6721 tagtcgtact cgatgccctt cgagtccagg agggcacggc tgcgtttgac gtcggggcac
     6781 cagccggcgc cgtacacgat gaggtcgctc atggatcaca gcatgccagg tcgcggtccg
     6841 gcggcgcgtt cggcgagtgc cgcacggtcg gcgagcccgg tcttggcgag caggctcgcg
     6901 acgtgtttct cgaccgtgcg cggcgagatg tgcaggcggg cgccgatgtc cttgttgccc
     6961 atccgctcgg cgagcagcac caggacctcg tattcgcgca cggtgacgcc ggacgctcgc
     7021 aggtccacgg ggacgcggtc gaccccggag cggcgctgcc ggacgggggc gccgagtttg
     7081 cgcaggaggg tccggcacgc ggccgcgacc gccgggatct ccctgcgatg gaagtactct
     7141 tcggcctcct tgagccagcc ggccggatca ccccagccgt cggcggcggc cggttcggcg
     7201 atcagccgga gcccgagatg ccgggcgagg ggatagggcg ccgacgtctc cagcgcggag
     7261 gccaccgcct gccctgccgc caccgcgtcg cctcgtctgc cgtgctcgac cgcgtgcgcg
     7321 aattcgacga actgccggtt ccaccgcatc ccgctcacgg cggagccgtc ctccgggcag
     7381 ggggcgccgt ggagggtctc gaccagcgtc cggagcccgt gcctgccggc gaggtggaac
     7441 cggctcggcc gccggtcctc cagctcgacg acctggccga gttcgcggcg agcccggtcg
     7501 aagtcctctt cgagcagtga acagaagacc cgcgcgagcc cgatgctgag caccatctcc
     7561 tgcgcgttct cgccgccgct ctcccggaag tcgtcgagcg cctgctccat cgccgggcgg
     7621 tccgcccggt gcccggcgga catcgctctc gtcatatggg cgtattgcaa cagcgcggtc
     7681 aaccggagcc tgccgagcac ggcgaggttc tccgccagca gcgcgtgcgc ggtgccgaat
     7741 tcgcagcgca ggatcgcgtg catggtgcgc acggaatcga ccgcgcagtg cagcgtgatc
     7801 gacccggtgc gctgggcgtc cgcgcgggcg agcagcaggg tctgctcgtc gccgttcatc
     7861 agcacgcgat gcccgccaag gcggaccagc gcctgggtgc gcagatggtg gagatggttg
     7921 tcctcggcgg tccgccgtgc gagctgcatg tagtgctcgg attcggtgag gtcccgcgac
     7981 agcgcgagca tgccgagcac ctgcagtgcc tggcacacga cgaacggctg ctcggtcgcc
     8041 tcggccacct tccaggcctg gcgcgcgagc cgttccgccg tgtccgcccg cccgggaacg
     8101 tccagccaga ggttcgcttc gacggcgtcg agcgcggctc gctgagcagg cgagatcgcc
     8161 gaaccgaggg gagcgcgggc gcgttcgatc tgggcgaggc attcgtcgtg ccgcccggcg
     8221 atgtaggccg cccaggcgag ctgggtatgc aacttcgcgg cccgttcgag ggtgccgatc
     8281 tcgccgaatc cggcggacag ctcgacggcg cggtcgaact gaccggtctg cccgagcgcg
     8341 tgcaccagcg tctccagcac ttcggcccga tcacccgcgt cggccccggc gagcaggtcg
     8401 acggccttgg tgagcatcgt gaccgcggag tcggcggcgc ccgcgtcgag ggcgcggcgg
     8461 ccggtttcgg cgaacaggcg tccggccgcc tgttcgtcca gcgcggtcag ccggagcgac
     8521 gcgacgagcg cgcacaggtc acccggcagc cccgggtaga gcttttcgac ggcgtcggcg
     8581 gcctgacggg cgagagccgc cttccgtgcc ggtgactggc gtgccagcaa cgcttcggcg
     8641 gtgagcggat gacggaaggc gtaccagccg ggtgtcgtcc cgtcggtggt caccaggttc
     8701 gccgagaccg cggcgctcag gtggttgtgc agagtccggt cgttggtgcc ggtgaccgtc
     8761 tggaccaccg tcagcgggaa gcggcggccg atgatcgccg cgaccgacag tagttcgccc
     8821 gcctgctcgc cgagttgctc catccggacg ccgatactgg tgaccagcgc ggcgggaacg
     8881 cgggcgcgga gttcgccgat gactcgccag ccgtcggggc cctcgaccag cagtccgtcg
     8941 ttcaccatgc cgtggagcag ttcctcgacg atgaacggaa ggccggcgct gttgcgccac
     9001 aacaggtccg ccgcggccga cggaagccgc tccggctcgg tctcgaggca ggcggcggcg
     9061 agggcgcggg tgtcggcgag gccgagcctg cccaattcga cgacggcgca gctcatccgt
     9121 tgcgccccgg aggtcgccag gcgcagtgcg tcggagggtt cgttgcggag cgttcccacg
     9181 aagaggacgt gcgccgagga caggttgtcg acgaggtatt cgagaatgaa cagcgtctcc
     9241 gcgtcggcgt cctggagatc gtcgaggacc aggagggcgc cgcggtcgcg gctggtgacg
     9301 gccagcagcc ggaacaccgc ttcggcgagc accagcaggg agcccgactc ccgcggccgg
     9361 tcgccccggc cccagtcggg gatgagctgg gcgagcacgg ggacgaacgg gtccagttcg
     9421 gccgccgacg gcgggcctcc gccgcggaaa tgcgaccaca gcgcctgggc cagcggacgg
     9481 aacgggacga gcgggccgat cgaaccggcc cgtccttgca gcaccgggat ttcggcggag
     9541 accgctcgtg cggcggcttc gatcgcgagc cgggacttgc cgatcccgcc ttcacccacg
     9601 aggaagatcg cgccgccgcg acccgcgatg gcgcgatcga gagctccgga gagctcggcc
     9661 agttcggcgt cgcggccgat cacccgcgac gaacggatac ccaccgccgt gactatagcg
     9721 agcggattcc cccgtcaccg gcgcgaaatg atcacggagg cgggcggcgc gaacccgcct
     9781 ccgtgagcct gtctcagatc cagccgccgg tgaagacgct gacgacggac ggcgaaccgg
     9841 ggtccgtgga cagggtggcg agcgggttgg cgctcagccg cggcttgccg cccgccagcg
     9901 cgtggttgcg cgagccgacc tcgagggcgc gcggcaggtt cacggcgccg aggacgtctt
     9961 cggtggcggg cagttctctg tcgtacatgc ggttttctcc tcatactcga tttaccggcg
    10021 gaactacgct ggccgcggga tgcggccggt ctgggcggag caggagcgcg gaggggaccc
    10081 ggtcaccgaa tcccagccgc agcaggccgt aaccgattcc cgccagaccg ctcagcagcc
    10141 ctggcgaggg caccgcgccg ggtgtcccgc agcgggcacc gcgctggtcg atggcggcga
    10201 gcagatgacc ggtccggcgg cgtaccgcgg cggcggcgcc agtgtgcccg ttctccgcca
    10261 gcacgcacaa cacgtccagc actccggact cgccgtggca gaggctgaga tccttcagcg
    10321 gcgccccgtc ggccagccgt ttgatcgtcc ggtcgaggtc cctggcgtgc ccgggatcgg
    10381 ctaggtgagc ggcgagcccg agcgcgtcac ccgcgagacc tccgcaccag ccgccggtgc
    10441 tttccgcccg atcgtccgcc cttccgggtg gttcttcgcc ggaacgatcg tgcgcccgca
    10501 acacccagtc gatcccggcc gaaccgcggg cgaacgactt ctctcgcgga cgttcacggc
    10561 cgagcagctc tccggcgtag cggtcggccc gcgtcagcgc cgtgtccagt cctgtttgga
    10621 catacaccga ccgcatcgac gcgacaccgc cggccagtcc tgtcgtgaac ccggacggtg
    10681 tttccggggt ggcgtcgggc atcaggtcga cggcctgctc gatgagatcg cccgcgggaa
    10741 ggccgaccag ggtgctgagc cgggcgatcg tgtacgcgac gccgccgagg ccgagaaggc
    10801 caccacatcc ggctgtggcg gccagctccc ggtcggcgcg gagcgtggcg aagaggccgg
    10861 ggagcgggct gatcgcgtac gcggccaggt cgcggtatcg cgcgatcccg gtcagttcgg
    10921 cgagctgagc gaggaacaac gcgacaccgc agtagccctc gccgagcccg gcgcccatcg
    10981 gcagcacggt ccagtaccgg tcgtcgacga gttcgatccc gagccagttg gaccggtgtt
    11041 cgtcggagaa ggcgttggcg acgatctggt cggcgatgcc gcacgcggtg accagcagcc
    11101 gttccgcgtc gggcgcctgg ttcggcgccg ccgtttccgc ggtctcgccg ccgagatggc
    11161 cgacggtcgc cgtgctgatg gcgagggtgg ccgagatcag ccattcctgg tcgcgctggt
    11221 cgagcgggtc catgtcggcg agcttggcca gcacggtgtc cagcgacggc cgttcgacca
    11281 cgccttcgac gttctcggcg cgtgaatcca ccagcgacgt cgagccgggg ttcgaggtga
    11341 acatcggcac gtcgcccgcc cagagatcgt cccgctcgtg gggcaccagg cggagcagct
    11401 tctcctcgtc ggcggaatcc tcttcgagca ggtcgaacgc gcggtcgcgg tcggcggcgt
    11461 cgcgaagcag atcgggatgg gtggtctcgt ccagtaatcg gaagtagaag ttcgtcggcc
    11521 ggatgagcac ccggatggga tcctcggcgc agcgccggag atgctcggcg agctcgtccc
    11581 gcgcgctgga gatcgcgtcg taaccgagcc ggaatccggc cagcagcgcg gcactgtgct
    11641 cggcgggcgt gacgtcgcgg ccgtcgagac gcggcaggtt gttcccgccc gagagttcgc
    11701 cgggcacccg caccagtcgc atgcggtcgg tgcccggatc ggcccagtcg acgcggtcgg
    11761 tgggcagctt gccaccgcgg ccggcgaggc cggagatgtc gaccgccccg tgttcgcccg
    11821 cgaagagctg tgggagcagc agcgtgcgct ggaccgagcg tgccagcatc gccgccgcgg
    11881 ggtcgccctc cggcggatcg ggcggcgatg gctggaagag ggtctcgatg tcgatcagca
    11941 ccggctggtc gccgcaggcg atgatgttct cgtagtggac gtcggtggcg tcgagcgagt
    12001 acaggagcgc caggaggatg ccttgccgcc ggtagaaacg gtcgacgtca ccgatatcgg
    12061 cgcacggccg gtgctcgacg aaccggagcc agccgtagcc cgcacgcggt agcgcgtccg
    12121 cggtccgcag ttcgagtccg ggcagccgtt tgttcagcag cgtgacgacg tcggtgaacc
    12181 gctcgtgcag gatcagcggc cggggtttgt agatcacctt ggcgccgctg gagaaccgga
    12241 gcagtttgac cgaacggccg cgggcgtgcg agtcgccgat cccgcccgcg acttcgacga
    12301 gcgcgccgag ttcgccgtcg acgaccgagc agggcagcaa ggcggcgtcg gccgagaacc
    12361 gggccagcgt ttcggcgtgg gcctcgacgg cgtggaggca cgcctgggcg acgagccggg
    12421 ccagcaccgg gtattcgccg aacaaccgga cgagcccggc cggagtggct tgccgtcgca
    12481 cgaaatccga gaagcgctct tcgggcgtct caccccggag gtgtccggcc ttgcggtcgc
    12541 ggtggagttc gaggaccagt gtccggaccg cgagcttcag cagatgctgg tcgagttgag
    12601 ccgcgaaacc ccggcggagg gcttcgacgt cggcgccagg gagatcgtcc gggaccgcgt
    12661 cacgggaagc ggcgtggacg agcggcctga agaccccggc gaagtcgaca cgccagtcac
    12721 cggctggggg acgctccggc agaagcgcgg tgaccgcgtg ttcggcgaag tccgcccagg
    12781 tgggcttgtc cgctgtccgt tcgcgcgggg tctggccggg tacccaccac ctcggcggca
    12841 gggacggcgc ggatggtcgg ggcgtcacgg aagtcatggt ttcagcccgg ggtcgcccgc
    12901 acatgggtgc cgcaccccca cattcagcgc acgcacgaag atgtccggag agtgacgggc
    12961 gagagagtct tcagcggaat atggggtcca ggcacccatg cgcggggacc ggtcccggtc
    13021 gcaccatggt cgggtggcgc ggaactcggg cgcgggccgg ttactggggg tccggcccgc
    13081 gtccgcccgg aacccttgag aattgacgca ctttcctatt cggtggtgaa aaaccggaac
    13141 ccggtaaagg gacacggtcg tgtcccttta ccgggtcgca aacacgaggg gccgacccgc
    13201 gccaacagat tggcccccgt caaaccctgt gcttagagcg tcagaccagc catccgagca
    13261 cgtgggccag gtgcgcgagc agacccgaga tcaggtcgtg gccgtggtgc acgtgctggg
    13321 tgaacatctg cattgagggg ctccttgtat cggatttcgt gttcggttgt gctctcgcga
    13381 ggagcgatcg aagattttca ccacgttggc acgctgtcaa aaaacgattt cccgggccgt
    13441 cggcgggtcg tgaatcttcc tacgataaac acgtaagtct ttcgtgtttt gcgccagggg
    13501 tgggcttcgc gggcgatgac actgtgcgta gcgagctcga ggcgggccaa tgtggaagct
    13561 aagcctccgc tacggcaagt gggcgggcgc gtgacacgaa ccggtgatcc acacgccacg
    13621 aatggtgagt cggtgagaat caccgatacg ggtgacgaca ccccgtgtcc gatagcagga
    13681 aggaagacgc tccgctcggg tgcgggacgg tgatcgctca cttacccacc gaaagcgggt
    13741 ttcctgtgtt tcgtcgaaca atcgcgaccg tcgccatcga gctggcgacc gcgttcggcg
    13801 gagcgtcccg gcggattcgg ccgcagccga caccgtcacc cagacctgga gctgtcatcc
    13861 gaggcttgcc agccagaccg tgcacgtgac catcaccgcg cccgccaccg tgaaaaggaa
    13921 cgtggaggct gccgttttcg tcaaggtcga cggcgtcgag ccatggccga attcggagct
    13981 gtcggcggcg tcggcctggt tggtcggctt cctgagacag ggaggggcgg gcaccggcga
    14041 ggtcaagatc gactcactga agaacccggc cacgatcccg aacggtgggc atttcagcgt
    14101 cgagggcaca cagcaggtca cgttctcgac tccaggcacc ggcaccctcg gccttcatcg
    14161 cttcggcagg ccgctcacct actggtagtg ctccttgccc gcggatcagc agccgccggt
    14221 ggacgcgacc gtgacagtga tctgaccgcc cggctccggt ggtgcggacc cgcaccaccg
    14281 gagcccgcgt cgtgccttac ctcttgatgt agagatccca cgtccaggtc gacgcggagc
    14341 agaagtaggc cgaccagcgg ccggcctgct ggccggagtg gccgttgatc cggcagtcgc
    14401 cctctgtgga ccagctggac tcgtagtagt acctcggatc gacacccgcg ccggcaggct
    14461 gcgcgaacgc gatcgtcgac gccagcgcgc ccaggacggc ggcggtcgcc gcgatcttct
    14521 tcttcacttg tgtagccccg gttctctcgg aacacttgcg tgcacaagta atcatgaatc
    14581 ggggtcgctt gtcctccgaa cgggcgagtt cgtgatcttg gctgtgggcc gaggcgatgg
    14641 gcaagggagt cgcgcaggtg ggtcgcccgc ccgttcacag cagctcggcg atatcgaacg
    14701 cgaggtcgag cgactggctg cggttgagcc tgggatcgca cgtggactcg tagcggtggt
    14761 gcaggtggtc gaccaggact tcgttactgc caccgacaca ctcggtcacg tcctctccgg
    14821 tgaactccac gtggacgcca ccgggatgcg taccgagtgc gcggtggacc tcgaagaagc
    14881 cgcgcacctc gtcgacgacg tcggcgaaca accgcgtctt gtggccgctc gaggccgtga
    14941 aggtgttgcc atgcatcggg tcacagattc agacggacac tccgccgacg gcttgggcgg
    15001 cccggatcag ggtggggagc cgatcacgga tctgccgcgc gcccatcctg gtgatgaagg
    15061 tcagcctgcc cggctcgcgg tccgggtcga gaatgtccac ataggatcgc acttcggcgg
    15121 gggtcgtcgt cggaccgagc ttgaccccga tggggttggc gatgcttctg aagtaggcga
    15181 cgtgggcgcc gtccaacgcg cgggtgcgtt cgccgatcca caacatatga ccactggtgg
    15241 cgtagtcgcg cccagtgctg tgatcggtgc gggtgagcgt gtcctcgtag tccagcagca
    15301 ggccctcgtg gctggcgaag atctcggccg agcgcagttc ttcgggctgg gcgccgcagg
    15361 cgcgcatgaa ccgtaacgcg cgatcgattt cgtaggccac ctcctcgtac cgggcacccg
    15421 acggcgagtt cgccacgaag tcccggttcc atcgatgcag ctgatcgagg ctcgcgtatc
    15481 cgttccgcgc gtagccgtcc acgatgtcca atgtggatcg tgatgcctcg tacatccgcc
    15541 acagccgggc cggatccggt cgccgcgccg cggcgtcgaa ggggtagccg ttcaccgcgt
    15601 cgccccggta caccggcagg gcgaggccgt cgcgagtctc ggtggagctc gaccgcggct
    15661 tcgcgtactg cccggccatc cggccgatct tgacgatcgg catcgcggcc gcgtgggtca
    15721 gcacgacggc catctgcagc agggtcttgg tcttggcctg gatcgccctc ggtgtcgcac
    15781 cgtcgaaggt ctccgcgcag tcgccgccct gcagcgcgaa ggcccggccg gaggccacct
    15841 ccgcgaggcg gtgccgcagg tcgtcgcacg cgcgtggggt gaccagcccg ggcgcggccg
    15901 acaacctggc gagcacctcg cgcagggcgg cgcgatccgg ccattccggt tggtgcgccg
    15961 cggtcgcgtc ccgccaaggg acgagtactt cggaattcgt cacgaaaggc agaccaccac
    16021 gatttcgcgc ttgtgcgcaa cgaattcgcc gagtggtccg gtcgagcgga gtcgaagtgg
    16081 tctgggcgcg ggcgctcccg gcttggttgt cttttccagc ggctgaatca gggaggtgcg
    16141 atagcgtgag gacgcaattc gtggacgtcg ccgtcgacgc gatcaccgtg cgaaccaccg
    16201 cgtccgcgct ggcggtgagg aacgaactgt gccgtcggtt cggtgcggaa gacgtctacc
    16261 tactggaaga cctgcatccg ggcaatctcg actccagccg gagtacggga accgtggtgg
    16321 ggttcggcag gctcgtcgag atctccgtgc tcggcgacga ggtgaccgtc cggggcgacg
    16381 gccgggtggc ggatctggtc cgggttctct gcggccggcc ggcggcgaat gtctgggaga
    16441 ccctgcgcga ggtcaccggc tcgttccggg tacggacgga ggtgccgggg ttcgccttcg
    16501 ggtttctcac caccgtcggc tacgacgccg ccgcgttgat ggaggagttg ccgccacgca
    16561 ggggcggacc cgacgttccg gacctgactc tcaccctgtt ccagcacacc gtgtggttcg
    16621 accgcgagga cgtaccgccg gtcttgcacg tggccaccgg gcccgacctc ccggagtcct
    16681 cgccccagga tgtcctgcgg aacatccccg gtgccgatgg tccgatgccg gaagcgacca
    16741 agccgcggtc agtgcgcgat tccgtcgaaa aggacacctt cctcggctgg gtcgagcgct
    16801 gtctcgagca catccgcgtc ggggacattt accagatcca ggtaggtcac cggatcgacg
    16861 tgcacagcga cctgacaccg gaagacgtgt accgccgctt gaggcatcga aatccttcgc
    16921 cctacatgta tctcatcacc cagtcgggca ggacgctcgt cggagcgagc ccggaggtgc
    16981 tcttccgggt cgacgacgac gccaggatca ccatgcggcc gatcgcgggc accacacgcc
    17041 gtgaccccgc cgggtcggac aacgagcgcc gtatcaagga actggtggcc agcaccaagg
    17101 aacaggccga gcacgtcatg ctggtcgacc tctgccgtaa cgacgtgggc cgggtgtgcc
    17161 gtccgggcac cctctcggtg gacgacctga tggcggtcga ggccttctcc cacgtgttcc
    17221 atctggtgtc cacggtgacg ggcacgatgg cgggtgggca tgacgtctgg gacgtactgt
    17281 gcgccacttt cccggccggg acgatgaccg gggcaccgaa gctgcgcgcg atggagatca
    17341 tcgacgagat cgaggtcgag cgccgcggcg tgtacgcggg tgccgtcggt ctcgtcgacc
    17401 ttcggggctg ggccgagctg gcgttgtgca tccggacgat cacgcaccac gagccatcgc
    17461 cgggtgacca ccggtactcc acgcagagtt gcgcgggcgt ggtggcgctg tccgaaccgg
    17521 agcgggaatg ggacgagacc ttggccaaga tgggggccac ctactgggcg ctcaccgggg
    17581 aggagccggc gtgaaggtgc tcgtggtgga tgtcttcgac agcttcgtcc acatcatcga
    17641 ccagtatctg cgacagctcg gtgcggacac cgcggtcgtg cgatccggca cgcgcacacc
    17701 ggaggagctg gcggcgacgc ggccggacgc ggtcgtgctc ggcccgggac ccggtcatcc
    17761 cgccgactcc ggccacgtgg atctggtccg gcggttcgcg ggcgaagtgc cactgctcgg
    17821 tgtgtgcctg ggacaccagg ccatcgcctt ggccttcggt ggagcggtcc ggctcgcgga
    17881 caacctcatg cacggacgca cgagcgtgat cgagcacgac ggccgaggtg tgtacacggg
    17941 cttgcccgag cggcacgagg tcacccggta tcactcgata gtcgtcgccg agccgttgcc
    18001 cggcgatctc gtccgcacgg cacggtccct cgacgacggc tacgtgatgg gaatgcggca
    18061 ccgggaactg cccatcgaag gcgtgcagtt ccacccggag agtgtcgcca ccgtcgacgg
    18121 cacgagaatg atggcgaact tcttggccgc tgtcacgacg cgagcagacc gctgacctcg
    18181 tccatcacgc tcgcgagcaa cttgacggag tccgcgagcc gcccgcgccg cacagcgcca
    18241 taaccgagca ccaacccgga cgaggcggga cggcggtcga gctggaagta ccggaccggc
    18301 tggacgagag ccgatcgccg cctggcctcg gcggacaccc gtccgtcgtc gattccggcg
    18361 ggcaacgcga cgtacgcgtg ggtgcccgcc ggcacaccgg tcatccgagc gcccggcagg
    18421 tgttcctcga tggcgtctcc caaggccgcg cgcctcgccc tgcaggtgcc gcggatctgc
    18481 cggatgtgct ggtcgagcag acccgacgag acgaagtggg cgaacgccag ctgggtcagc
    18541 gcgtccgggg cccccagctg cgcctggctg agccgcttgg cgaccacgcc gggtaccacc
    18601 gaccagccga gccgcaggcc gggaccgagc aggccacgcg tcgacccggc gtagatcacc
    18661 cggtgtgtcc gatgccgttg cagggcgagc ggaccactgc cggcgccgaa ccacaggtca
    18721 ccgtcccggt cgtgttcgac cacccagccg tccacttggt cggcccagcg caggagctcc
    18781 ttccggcggc tcgccgagag catgacgccg gtcggtacct gtgagaccgg cgtgatcagc
    18841 accgcccggg ctccggatcg agcgagcgcc tcgacgtcga tgccctcgcg gtccaccggc
    18901 actccggtca ctcgcaggcc cgcgcgttcc gcgatcccgg ccagccacgg cgtaccgggg
    18961 ttctccacgg cgatgtgtcc ggcaccgagg tcgtgcaggg cgtggcacag gccttcgaag
    19021 acatgcgcga agtccgcggc gacgacgacc tcggaagcac cggtcagtac ccctcgcgaa
    19081 cggccgaggt acgcggcgag ttcggtacgc agttccgcga caccgagcgg gtgccgtcgc
    19141 ggaccggtgc ccccgatcga tcgagccatg tgccggtagg cgtgcagcca ttcacgctcg
    19201 gggaagaacg ccgtactcgt cgcgtcgacc cgaaggtcga accgtacgtc cacgagctcg
    19261 gacggccgtc tcgccccagc cgtgccgaga cgaggcagat gcgtcgccac ctgggtgccc
    19321 gatccctgcg tggctctgag atatccctcg gcgatcagct gttcgtaggc ctggaccacg
    19381 acaccgcgtg agaccccgag atccgcggcg agagtacggc tcgacggtag ccgcacccct
    19441 tggtgcaacg tgctgtccgt gatccgctca cggatcgccg attcgacctg cgcggtcaag
    19501 gacaacggcg aatcacggtc gatggtgatc ggcaacattc ttcccccacg acggaaatgg
    19561 tccgcttcaa gcggtgtcga atggtctagg ccggcacctc cgccgcctgg aacgctgaac
    19621 ccggcatccg agcggaggag gaacgatggc gggcggggag accacgatcg agacggatcg
    19681 gaagcggtgg gcggaaatac tttcggcgct cacccagggg tatgacctca ccgcagagga
    19741 cacggagtgg gcgctgggag aggtcatgcg cggcgcggcg ggcgaggcca ggctgagcgg
    19801 cctcctgatc ggcctgcggt ccaaagggga gaccgcccag gaactcgacg gcctggtgcg
    19861 agcgatggac gcgcatgcgg tccggatcgc ggtggacggg cccttgctgg acatcgtcgg
    19921 caccggtggc gaccaggcgg gcacggtgaa catctccacc atgtcggcga tcgtcgccgc
    19981 ggcggcggga gcgcggatcg tcaagcacgg caacaggtcg gcgtcctcgc agtgtggttc
    20041 cgccgatctg ctcgaagcgc tcggcgtcgt catcgacctt ccggcggcga cggtgcgcca
    20101 ggtactttcc gaggtgggta tcgcattctg cttcgccccg gtgttccatc ccgcgatgcg
    20161 ccatgcttcc caggtacgcc ggcaactcgg cgttccgacg gtcttcaacg tactgggccc
    20221 gttgacgaat cccgccgcgc cggccgcgtc cgccatcggt gtggccgaag cccggatggc
    20281 gccgatcgtc gccgaggtcc tgtcccgtcg aggacgctcc gccctggtct tccgcgggga
    20341 cgacgggctc gacgagctga cggtcaccac gacctcccag gtgtggaccg tgtacgacgg
    20401 aaccgtacgg caggagacct tcgacccgcg cgacctcggt atcccgctgg tgtcaccgga
    20461 ccggttgcgt gggggagggc cggcgcgcaa cgccgagatc accctggatt tcctcgacgg
    20521 cgcaacaggt ccggtccgtg acgcggtcct cctttccgcc gccgcgggac tcgccgcgac
    20581 cgcgcccggc accgcgccga tcacggagcg gttgggtgtg tgcttcgaga aggccgctag
    20641 cgccgtcgac agtggtgacg ccggggccct gctcggccag tgggtcaggg tgacgggcaa
    20701 gctggccgaa tagccttcgg tcattccacc tcctccctcc gtcccgccgc cagcatcgcc
    20761 gcgaccgcgt cggccggacg gtcgtcgatg acgagagccg agccgacgag caccgcgtcg
    20821 gcaccggctc cggcgtacga gccgacgtcg gccggccctc gtacgccgga ctcggcgacc
    20881 gtgacgacgt cggcgggtat cccggccgcc agccggggaa aagtgtcacg atcgacctgc
    20941 agcgtcgtca gattccgggc gttcaccccg atgatccggg caccggcggc caccgctgtc
    21001 gcgacctcct gttcggtgtg tgtctccacc aatacggcca gcccgtactc ggccgcctcc
    21061 ttcagcagtc cgtcgagttg ccgcccgctc aacgccgcga cgatcagcag caccaggtcg
    21121 gcgccggcgg cggcggattc ggccagctgg tacggatcga cgatgaaatc cttgcgcagc
    21181 aagggaacac tgaccgaatc acggacggcg cgcaggtcgt ccagcgagcc gccgaagtgc
    21241 ctcggttcgg tcagcacgct gatcgcggcc gccccgcccg cgacgtattc ggcggcgagc
    21301 gcctccggcc gctcgatcgc cgccagcctg cccatggccg ggctgacccg tttgacctcg
    21361 gcgatcagcc ggacgccgtg ggtgccgcgc aacgcggccc ccacggcgtc cggcgtcatc
    21421 cgggggccac gggcctcggc gcggcggcgc aggaccgccg ggctcacctc ggccatccga
    21481 acaggcaggt ccgtgcgaac tccggccacg atctccgcca gcacgttcac cttgtcgccc
    21541 cctgcccgcg cttaccggga aacggtcgtg ttcgccggcg acacgagcgt gtcgagcgag
    21601 accacgtagt cgatcatctg ctcttgactc cgcatcggac gttcaggatc gaagcggatc
    21661 tcctcgaagg tctcgaccac tcgctccacc acgacacggc cgagcgtgcg taccagcggc
    21721 agtcccaggc agatgtacat tccctgcccg aaggtcagat gcgggttcgg cgagcgcgtg
    21781 atgtcgaacc ggtgcgcctg cgggaaccgg gtctcgtcga agttggccgc cgagtcccag
    21841 accacgatgt agctgcccgc tttgatctcg cgtccgccca gttcggtgtc gtgccgcgcg
    21901 gtgcgccaga ggttgaacca cgagaagtcg aagcgcaaga cctcctcgat cgccccgggg
    21961 atcagcgaag gatcgctccg cagggcctgg tagaactccg gattccggca gaacctggcg
    22021 aacatgtagg acagcagcag cgacgtcggc gcgttgcccg ccgtcaccag gtccaggcac
    22081 atgtggatga tcttctcttc cggcagccgg tcgtccttcg cccgtgcctg cagcaacgcg
    22141 ctcatcaggt cgccggtcgg cttgcgctta cgctgatcga gctgatcggt gagcatgccg
    22201 acgacctcgg cgtgatccgg ctggaagatc ccgacgagct gaccgaacat ctggtccgac
    22261 cattgccgga agcggtcggg cccggggatc tgcagcccga acagatgccc gatcacgtgc
    22321 tccatcaacg gatagccgag gtcgccgagg acctccaggc gaccggaagc cagtgcgggc
    22381 ttcagcaacg cgtcgaccat cggtgcgaag tcggacgcgt gggcttcgat gttgcccggc
    22441 acgaaggaac gggccacgaa gctgcgcaga aagcggtgct cctggatgtc ggcccggccg
    22501 aacgagaacg gcagacccat gtgggtcttg ttggtcaccg agaaggtgtc cgggtccttg
    22561 agcacccgtt ggacgtcctc gtatcggaac acctcccaca ggttgtattc cggacggtgc
    22621 cgcagtggct cgacccggtg ctggtgctgg aaccaggcga tacgttcctc gatcgagtcg
    22681 ctcagatcgg ggaacaacag atccctggtc ggcttactgg aggtactggt cacttcttgc
    22741 ctctcctacg acttcggtgc gtgtccgccg gaacccggcg gtcagaggcg ttccgcggtg
    22801 atccagatga ggtccttcgt gcggaaggtg ctttcccaga ccgcttggcc gaccttgggc
    22861 agccggtcga tgtgctc
//
