LOCUS       NZ_CP102512            20621 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces sp. CA-210063 chromosome, complete genome.
ACCESSION   NZ_CP102512
VERSION     NZ_CP102512.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CA-210063
  ORGANISM  Streptomyces sp. CA-210063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10859970)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Jorgensen,T.S., Klitgaard,A.K.,
            Mourched,A.S., Blin,K., Oves-Costales,D., Genilloud,O., Larsen,T.O.,
            Tanner,D., Weber,T., Gotfredsen,C.H. and Charusanti,P.
  TITLE     Identification of the Biosynthetic Gene Cluster for Pyracrimycin A,
            an Antibiotic Produced by Streptomyces sp
  JOURNAL   ACS Chem Biol 17 (9), 2411-2417 (2022)
   PUBMED   36040247
REFERENCE   2  (bases 1 to 10859970)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Assembly Name                     :: M642_aaa1.6.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 55.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 11:12:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,501
            CDSs (total)                      :: 9,410
            Genes (coding)                    :: 9,051
            CDSs (with protein)               :: 9,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 141 of 359
            Pseudo Genes (incomplete)         :: 302 of 359
            Pseudo Genes (internal stop)      :: 23 of 359
            Pseudo Genes (multiple problems)  :: 101 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9528309
            Orig. end                         :: 9548930
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102512.1.
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20621
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="31"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20621
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20621
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10621](-)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10621)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     gene            <131..277
                     /locus_tag="JIX56_RS41785"
                     /old_locus_tag="JIX56_41785"
                     /pseudo=""
     CDS             <131..277
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717585.1"
                     /locus_tag="JIX56_RS41785"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41785"
                     /product="SDR family oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KSQFAAAVPLGRIGRPDEVADVVAFLASGQSSFILGANLYVDGGE
                     NQT"
     gene            complement(287..586)
                     /locus_tag="JIX56_RS41790"
                     /old_locus_tag="JIX56_41790"
     CDS             complement(287..586)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="JIX56_RS41790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41790"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_331597675.1"
                     /transl_table=11
                     /translation="MMQTGIHTGAVAAAQDLTADQPLRETAWEMLIRALYLAGRPAEAI
                     HAYERVGRLLMTELGLQPSPALRDLSLAIRRRDRPAATPHVRGVGQGLLGMCWS"
     gene            complement(986..2098)
                     /locus_tag="JIX56_RS41795"
                     /old_locus_tag="JIX56_41795"
     CDS             complement(986..2098)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032130.1"
                     /locus_tag="JIX56_RS41795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41795"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_257548912.1"
                     /sec_met_domain="Abi (E-value: 1.9e-14, bitscore: 52.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFSAPVPLPPPAVPAAGEPHPYHRLAHATGRHRWWRPLVGTVMV
                     IVGWILLFIVTDAFAYGFGTAKGYPEDGDGGIDFGPVVNTAQSLAYLAVAIPVVLLTVR
                     WAGRRPAGTISSVEGRLRKRWLALCVLVAVPVVALTMAAMLFLPVGETSGTGDDVWVGL
                     YRYLPILGMLVVLVPLQSAAEEYVFRGWLLQAVGAFFRSPWIAVLPQAVLFAAAHGWGT
                     TAGFLDLVVFGGIAGWLTVRTGGLEAATALHALNNLVSFAVGAAFVGGLDSDETAADLP
                     WQLAAIDTTMIVVYAAAVLWLARRRWPHGALSSPSAPPADKFPYPYQLAYAPPAPEGQQ
                     HGGSAGEPTDPAVAQAHPRTAWHATDGTRP"
     gene            2252..>2401
                     /locus_tag="JIX56_RS41800"
                     /old_locus_tag="JIX56_41800"
                     /pseudo=""
     CDS             2252..>2401
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024591.4"
                     /locus_tag="JIX56_RS41800"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41800"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAPAVDHPVQRRLADHPAVAEACVIGVPDDKWGERPMTCVVFAEG
                     RVGAA"
     gene            complement(2453..>2716)
                     /locus_tag="JIX56_RS41805"
                     /old_locus_tag="JIX56_41805"
                     /pseudo=""
     CDS             complement(2453..>2716)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969375.1"
                     /locus_tag="JIX56_RS41805"
                     /note="FabF; beta-ketoacyl-ACP synthase II, KASII;
                     catalyzes a condensation reaction in fatty acid
                     biosynthesis: addition of an acyl acceptor of two carbons
                     from malonyl-ACP; required for the elongation of
                     short-chain unsaturated acyl-ACP; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="JIX56_41805"
                     /product="beta-ketoacyl-ACP synthase"
                     /pseudo=""
                     /sec_met_domain="FabF (E-value: 2.3e-31, bitscore: 108.1,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="HVAVSATKSMTGHLLGGAGGIETVATVLALRHRTAPPTINITDRD
                     DEIDPSLLSSRPRPLPGGPLVALNNSFGFGGHNVVLGFRVGG"
     gene            2714..2974
                     /locus_tag="JIX56_RS41810"
                     /old_locus_tag="JIX56_41810"
     CDS             2714..2974
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016430.4"
                     /locus_tag="JIX56_RS41810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41810"
                     /product="sigma factor"
                     /protein_id="WP_257548921.1"
                     /transl_table=11
                     /translation="MTPTREGSDCETFVRELYEHHGKDLLRFASRLLGGDWHQAEDIVQ
                     EAATRAWHHVETLPVGQCEGLMAERALEPAPLARRSCPQDR"
     misc_feature    2942..2944
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3007..4599
                     /locus_tag="JIX56_RS41815"
                     /old_locus_tag="JIX56_41815"
     CDS             3007..4599
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153885.1"
                     /locus_tag="JIX56_RS41815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41815"
                     /product="peptidoglycan-binding domain-containing protein"
                     /protein_id="WP_257548923.1"
                     /transl_table=11
                     /translation="MSLWTSLEPASALVDPGASTTVRLRVRNTGDIVDEYRFEPVGDVA
                     PWATVEPQTLRLYPGTTGTVELTLSPPRSPDATAGANPYAVRIVPTVHPEATTVVEGNL
                     SITAFTEVRAELVPPTVKGRFRGRPQLAIDNLGNTKLTASIGSENDDQLAYDIRPANVQ
                     IEPGRAAFVHVTLKPRETIWFGSKEERPYTLAVRRSGTDPRTVDGTFVQRGFLPRWLAT
                     CLSVALALAITFAVLWFGHQPQVRSSATEWSEEVSTTVLPSPEPPASELPSPDASDAEQ
                     EALPDGADDDTAADPGGSSGEGGGSEGSGGSGGSAPEQEDKAAPSGPLPFRRGDGPNLF
                     VQFAQVRMETARASDPCRLTGDHRLGVMDAATVQAIKCFQKANDERNDGVTIKTDGAGN
                     LGRATMTALLMAHFGDSTSTLQPGKKNPEVVWLNSILLWADNVQYDTNDVKAMDSYVRA
                     NIHYLKSADNRASNSADGGFADRVASYQRNLGLPATGKVDAAMFAALHAGKVKGQNQPG
                     QVTAADFPPLPVV"
     gene            4726..5419
                     /locus_tag="JIX56_RS41820"
                     /old_locus_tag="JIX56_41820"
                     /pseudo=""
     CDS             4726..5419
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993311.1"
                     /locus_tag="JIX56_RS41820"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41820"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MMGTSDDTRAAESTQPRRKRVPVLVHAQDPISRAGVVSQLCEHAV
                     IDLVEENEENEEYTAPPGVMAVVVAETLDDATAAGLRKLVRGDGVRPVLVVSLLRGNEL
                     LSAIECGVGAVVWRREATAQRLVRAVLDASRGDGNLPADLLGRLMNQVGMMHRGAANHP
                     GLAPPGAGAARGRRAAADRRGAGHGRDREQAVLLATHGQGHPAQPHHPSAPAQSKPRRG
                     LCPRGGLHL"
     gene            5764..6678
                     /locus_tag="JIX56_RS41825"
                     /old_locus_tag="JIX56_41825"
     CDS             5764..6678
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326709.1"
                     /locus_tag="JIX56_RS41825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41825"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_257548925.1"
                     /transl_table=11
                     /translation="MVHGPRGGTTGAVEVARLGGLWRVTRPWHPGLRPFLRSYVGYWEA
                     VTSPYEARLVPTGCATLLISLAEPFSQVRRLGVPGGGSGNIGSLVVGLEDRPAICAHPG
                     GQEAIRVEFTPLGAYRLFGMPMSELTNLAIEIRDVLGPEAGVLVERLASTRDWAARFDL
                     LDAALLARLGRGPEPAPEVGHAWRLLSGSAGVIPIARIAAEVGWSQGYLIRRFTQQIGL
                     TPKASARVLRFRHAVAMLSHSAASLTEISTACGFYDQAHLNREFRAIAGTTPGQMVASR
                     RVEGALALSASANSSKTGPPAGR"
     gene            6757..7005
                     /locus_tag="JIX56_RS41830"
                     /old_locus_tag="JIX56_41830"
     CDS             6757..7005
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS41830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_41830"
                     /product="hypothetical protein"
                     /protein_id="WP_257548927.1"
                     /transl_table=11
                     /translation="MTATSVAVPARLNGGLLLTVITSEQAGGLASAGAEVTCAHGAIAR
                     RGFVERAQGVRPARHHPRTDTSDRSRVGRADRYDGFT"
     gene            complement(6987..7808)
                     /locus_tag="JIX56_RS41835"
                     /old_locus_tag="JIX56_41835"
     CDS             complement(6987..7808)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005800.1"
                     /locus_tag="JIX56_RS41835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41835"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_257548929.1"
                     /transl_table=11
                     /translation="MSTSTTTTTAATSSPPTTTGIVDDIGYGRQFDGWYHRLFPDDASV
                     VAEVERLASLHPDPASGTVEFGVGNGRIALPLSRRVGRITGIDSSPEMLDVLRRNLADD
                     TSVEPVHADIRTYTADRTVGLVYCVCATLSMLLTPEEQRQAVQRAADLLAPGGRLVLET
                     HNKPAILALHEGRSRATYFTPYPEPGTGLQSHSLLLPEGSLWHLSHVWYESDGTTRVGT
                     EVSRLTAPEELDAYARAAGLEPETRFGDWPTDAEPYAPHSPLAICAYVKPS"
     gene            complement(7805..7996)
                     /locus_tag="JIX56_RS41840"
                     /old_locus_tag="JIX56_41840"
     CDS             complement(7805..7996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474572.1"
                     /locus_tag="JIX56_RS41840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41840"
                     /product="hypothetical protein"
                     /protein_id="WP_257548931.1"
                     /transl_table=11
                     /translation="MNDFLLTPLVVALGIVGFLIATGAVSTPAVIGAALVALFGACAQA
                     RRNTHPRNTPPKKRRQHP"
     gene            complement(8041..9876)
                     /locus_tag="JIX56_RS41845"
                     /old_locus_tag="JIX56_41845"
     CDS             complement(8041..9876)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009307479.1"
                     /locus_tag="JIX56_RS41845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41845"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257548933.1"
                     /transl_table=11
                     /translation="MNPAGTRPPTRPRAVHRAVPELHLHLLWGKGAKPWRALGRHRGLI
                     ALGILLGLLGAAASLAQPAVIGGLVASVENQQPVTGPILIAAALFLADAVLGALHSYVI
                     GLAGENIVYDIRSNLAARLLRSRFRAYSGWKQGDVFARMVSDTLLARTTMTHAIDSIIQ
                     NGFLVVGGIALMAWVDEVLLLATLGCLGVTSVISLWLARGVRKVSVLNQTDTGNFGSAL
                     MRVLGAMPTVKASRAEAREAEGISDIAKQARKSGIKVTVLSSLLDPTMSIGTQLALTVV
                     IALGAARTATGEMTAADLTAFILYLFYLVAPLLTLFTSIAQFQVGRASIDRLAELGKIE
                     VEGERPADRPADRRRGPRPARTAYNTGLAFDAVTFAYPGSEKVVLDDVSFTVPASGLTA
                     VVGPSGAGKSTVFQLIERLFDPVSGAIRIDGTDITDLPLNQLRSIVGYVDQDHTLLRGT
                     VRENLTYSAPDAGDKDIAEALRMANLTEVIAALPHGLDTELGDRGAGLSGGQRQRLAIA
                     RTLLQAPRFLLLDEATANLDSESENALRDSITMISEFCAVIAIAHRLSTVTEAQRIVVL
                     DRGQVHAVGTHDELHRHSGLYRRLARLQELSDVAS"
     gene            complement(9873..9998)
                     /locus_tag="JIX56_RS41850"
                     /old_locus_tag="JIX56_41850"
     CDS             complement(9873..9998)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS41850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_41850"
                     /product="hypothetical protein"
                     /protein_id="WP_257548935.1"
                     /transl_table=11
                     /translation="MSLDNPFFISGLVLIGLGFVKAALLYVQVVRERKHDGSDAE"
     gene            complement(10001..10621)
                     /locus_tag="JIX56_RS41855"
                     /old_locus_tag="JIX56_41855"
     CDS             complement(10001..10621)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474565.1"
                     /locus_tag="JIX56_RS41855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41855"
                     /product="hypothetical protein"
                     /protein_id="WP_257548937.1"
                     /sec_met_domain="cypI (E-value: 1.3e-32, bitscore: 112.1,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSLPRLRLKSAFTGEGAPWRIAGAALLLLTLAGQHPHQHFGRVR
                     SRDHFSLLPNWRFFAPHPAMFDFHFLYRTVSGDGAASGWRDASGIEERKPLHLVWFPTR
                     RADKSVFDACQEILPRLDQGFTAAAHTPGYRLISEHVRTRIAAEDASADDVRGFQFALA
                     SSTGYDMRQGPQLMFVSPFVPLDPHAPSTPLTPLAPAKTEVRT"
     gene            complement(10618..12441)
                     /locus_tag="JIX56_RS41860"
                     /old_locus_tag="JIX56_41860"
     CDS             complement(10618..12441)
                     /NRPS_PKS="Domain: Abhydrolase_1 (323-429). E-value:
                     1.8e-10. Score: 32.8. Matches aSDomain:
                     nrpspksdomains_JIX56_RS41860_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009307499.1"
                     /locus_tag="JIX56_RS41860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41860"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_257548939.1"
                     /sec_met_domain="PF00561 (E-value: 3.4e-07, bitscore: 29.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.3e-16, bitscore:
                     60.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERLAAVSSLQSSLEYLTQRKDIEKGGMNDWEVARQYLAGAGPL
                     TRRLVDSVSGVHTTTALHVARSAVAVGMLLPGNSRWRGAGNLFLGASSAVLAPRHHYGG
                     DGSDQVATLVQIATGAARLAPSPAAKDALVWYAALQANMAYAVSGWVKLFGKPWRDASA
                     LGGVMRTRTYGHEGIFRWTQEHPKTAKALTHSVLALECLFPLAYARGGTLTRSMITSAA
                     AFHVANGYFMGLSRFVTAFPAFHPLVAYTSTPRSHAAVAGRDDRAVKAALVALAGGTAA
                     AAVTAVRRRLRTTEGWHSSRMLTTRHGNRLQYEEYSPGDPDQPVVVLASGLLSTSEHYA
                     WISERLAHETRYGIVAYARAGYAGSRREATSPYRLSESVHDLVDLVNGAVAPHREVILV
                     GHSIGGEIARRAARHLGDRLRGIVYLDSSHPGQFAGGLSQVEKGLSEHFTSVSRALRLG
                     TGALLTRPVWITELPYAYRKKVFAQYADARMWEAARREWKAVRDDFASFKGALARIEGV
                     PALVISAQRTVDTNPEQLLLHKELAEAHVGARSEAVVIEGATHESMLINSRYAHQVTDR
                     VVAFFGAPDRRSPGSGPSRPSRPAPRKEATR"
     aSDomain        complement(11155..11472)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIX56_RS41860_Abhydrolase_1.1"
                     /evalue="1.80E-10"
                     /label="JIX56_RS41860_Abhydrolase_1.1"
                     /locus_tag="JIX56_RS41860"
                     /protein_end="429"
                     /protein_start="323"
                     /score="32.8"
                     /tool="antismash"
                     /translation="PVVVLASGLLSTSEHYAWISERLAHETRYGIVAYARAGYAGSRRE
                     ATSPYRLSESVHDLVDLVNGAVAPHREVILVGHSIGGEIARRAARHLGDRLRGIVYLDS
                     SH"
     CDS_motif       complement(11197..11268)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIX56_RS41860_0001"
                     /evalue="4.80E-04"
                     /label="NRPS-te1"
                     /locus_tag="JIX56_RS41860"
                     /protein_end="415"
                     /protein_start="391"
                     /score="12.7"
                     /tool="antismash"
                     /translation="PHREVILVGHSIGGEIARRAARHL"
     misc_feature    12519..12533
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.47"
                     /tool="antismash"
     gene            complement(12684..12971)
                     /locus_tag="JIX56_RS41865"
                     /old_locus_tag="JIX56_41865"
     CDS             complement(12684..12971)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474562.1"
                     /locus_tag="JIX56_RS41865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41865"
                     /product="hypothetical protein"
                     /protein_id="WP_257548940.1"
                     /transl_table=11
                     /translation="MSIIAKAMDRMDLPVEGVILASARPTLGTPRIGRVANGANALAAL
                     GGLADLAQVGGGVAQVVGAASAVEANNAAADANQAIANAANAQAAAVGGV"
     misc_feature    12960..12975
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.92"
                     /tool="antismash"
     misc_feature    complement(12963..12978)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.83"
                     /tool="antismash"
     misc_feature    complement(13045..13056)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.78"
                     /tool="antismash"
     misc_feature    13100..13114
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.32"
                     /tool="antismash"
     misc_feature    complement(13127..13142)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(13168..13182)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     misc_feature    complement(13168..13183)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.25"
                     /tool="antismash"
     misc_feature    13169..13183
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     gene            complement(13220..14632)
                     /locus_tag="JIX56_RS41870"
                     /old_locus_tag="JIX56_41870"
     CDS             complement(13220..14632)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114658.1"
                     /locus_tag="JIX56_RS41870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41870"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_257548942.1"
                     /sec_met_domain="DAO (E-value: 5.7e-07, bitscore: 28.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAVVVGSGPNGLAAATFLAREGVEVTVLEAADAIGGGTRTSEL
                     TPGLLHDHCSATHPMTVGSPFLRGLDLGRHGLTWRLPDIDCVHPLDSGGAGVLHRSVEE
                     TADGLDGGDGRNWRRVFRPLADGYDELAEDLMQPLGHVPKHPLRLAAFGPQALLPAAAV
                     ARLWRAETTRALFAGVAAHAFRPFHRPASAAVGLTIIAAGHRHGWPVAAGGSRAISDAL
                     AARLAEFGGRIETGVRVRSQADLPPADVVLFDLAPRAVADILGDRLPARVARAYRRYRH
                     GPGAFKVDFAVEGGVPWTNEAARRAGTVHLGGTYEEVAAGERAIHAGRMPERPFVLVGQ
                     QYLADPRRSKGDVHPVWTYAHVPHGYDGDATEAVVAQIERFAPGFRERVLDMAVRSPAG
                     FEEYNPNYVGGDIIAGANTAFQLVLRPRAALDPYSTGVPGMYICSAATPPGAGAHGMCG
                     ANAAASALRRLR"
     gene            complement(14858..16204)
                     /locus_tag="JIX56_RS41875"
                     /old_locus_tag="JIX56_41875"
     CDS             complement(14858..16204)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005808.1"
                     /locus_tag="JIX56_RS41875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41875"
                     /product="histidine kinase"
                     /protein_id="WP_257548944.1"
                     /transl_table=11
                     /translation="MTTSSLAALSARATQPHHGPSRLPARRLNHRALYPALGVLWLLDI
                     GIIGSQQRGPVDWLPLVTGPLALALVLVPEPRLSTEWRAGVCAAVSTTVTLVTLLMGAA
                     LPEWGLLETACMLVLLARTCRNVTRPGITLALAAAMGASIIDEPLRTGGTGITLTYPFL
                     LTFAVGGAVGAGCYLRTLDARRSRTIAAVRLAERIQLARELHDFVAHHVTGIIAQAHAA
                     GVIHESSPHQVGPILSNIAEAGQRTMDSMRRLIRVLREEGEQTTIERPEEPYAELTKLV
                     SSFSGQGDGSTAQLEVTGAARRSTLLPEVGSAVHRVVQEALTNVRRHAPGTQATVRVHR
                     TREDLLRVDVYNDGPERRGSRPTGGHGGYGLIGLRERAEAVGGSLTAGPADDGGWWLIA
                     HFPVLTEAELQRDAERSAAPVPPARPHHGRHARPNARTEPEPDMNWDAG"
     misc_feature    complement(16136..16138)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16304..16993)
                     /locus_tag="JIX56_RS41880"
                     /old_locus_tag="JIX56_41880"
     CDS             complement(16304..16993)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474556.1"
                     /locus_tag="JIX56_RS41880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41880"
                     /product="response regulator transcription factor"
                     /protein_id="WP_257551425.1"
                     /transl_table=11
                     /translation="MLGRVSSTPTRVVIADDQDLIRAGFRLILDAQEGIEVVGEAADGL
                     ACVELARALRPDVCLVDVRMPKLDGLEVTRLLSGPGAMYPTQVVVVTSFDQDDYLDVAL
                     RNGACGFLLKDATPALLVEAVRAAARGDALVSPAVTVRLLKRLEERAAAPANGTGVPES
                     SLSARELDVARLVAVGRTNQEISDELCLSLSTVKTHLGHIHHKLGVRNRVEVAAWAWAN
                     GTVRTAH"
     misc_feature    17174..17189
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            17248..17577
                     /locus_tag="JIX56_RS41885"
                     /old_locus_tag="JIX56_41885"
     CDS             17248..17577
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005810.1"
                     /locus_tag="JIX56_RS41885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41885"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257548945.1"
                     /transl_table=11
                     /translation="MTVDTSGRLSTRELEILLLAAHGMSDADMSQELSISPRTVASHMR
                     SIREKLCAKNRTHLIAIALRLGILALRTDRTDRMGGSRWPDRLDRLDETFRLTGLSGGR
                     AQPVA"
     gene            complement(17665..18453)
                     /locus_tag="JIX56_RS41890"
                     /old_locus_tag="JIX56_41890"
     CDS             complement(17665..18453)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993055.1"
                     /locus_tag="JIX56_RS41890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41890"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_257548946.1"
                     /transl_table=11
                     /translation="MSEGRGVRGVKSAARTVALLELLAARGERPSRLDELAEDLDVPRS
                     SMYQLLQTLVDCGWVRTDATGSLYGIGIRALLTGTSYLDGDRRIRAVRPYLDEASDALG
                     ETIHLARLDGPDVVYLATRESHEYLRTISRVGRRVPAHAGALGKALLAERPDDELPFTD
                     ESLTALTENTHTSRTALLADLARVRERGYSIDREETVTGIAGFGFALRYDTPATDAISC
                     SVPVARLTGEHEAHIISVMREVRATIESRLPPASGTPDWR"
     gene            18610..19947
                     /locus_tag="JIX56_RS41895"
                     /old_locus_tag="JIX56_41895"
     CDS             18610..19947
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015295 - solute:proton symporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0015718 - monocarboxylic acid transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579130.1"
                     /locus_tag="JIX56_RS41895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_41895"
                     /product="gluconate:H+ symporter"
                     /protein_id="WP_257548947.1"
                     /transl_table=11
                     /translation="MPLLVVGISVLILLLLMTRLRLNGFAALLLVAVGVALVRGIPVAT
                     IPDVLSEGIGGQIGDTMLTIGLGAMVGRVMGDSGAAQRIAGKLLDAFGPRWVQVAMVVT
                     SMLIGVTMFYEVAFIIIVPIAFTLVRVTGAKLLWVGLPMSIALSTMHSFLPPHPGPTAV
                     AATFHASVGLTLFYGLFIAVPAGALIALTWPRLPFVRALDPAIPKGLVTEREFTDEEMP
                     GLGWSLFVALFPVVLIVAAAVTDMATSTESPLLNSVAFLGSAPIALLLTLCLAIWAFGP
                     RIGRSLEEVGASCTSAAKAMAMILLVIGAGGAFKNVLVEGGISDYIKDATDSWSISPIV
                     LAWLVAVILRIALGSATVAVVTASGVVLPLLAGSGVHPEMMVLAVACGSIACSHVNDPG
                     FWLFKEYFNLSVIEAIKVRTSYTTVLAILGLGGVLAAEWALDVLSL"
     misc_feature    complement(20273..20288)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    20337..20351
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 gggcggtgca gcggacagtc ggcaactcgc atccgccgag cacgagttgc tcgacattcg
       61 acccgggtgt ggttttcagg cgcacactcc tggactcgac gccgtggccg cgggagacac
      121 acccctcacc aagtcacagt tcgccgcagc tgtcccactg ggccggatcg gacgcccgga
      181 cgaggtcgcc gacgtggtgg ctttcctcgc ttctgggcag agcagcttca ttctcggagc
      241 caacctgtac gtcgacggcg gcgagaacca gacctgaaac gagtagctat gaccagcaca
      301 tccccaacag gccctggccc acgccgcgta cgtgcggtgt cgcggcgggc cggtcgcggc
      361 ggcggatcgc gagcgagagg tcccgcaggg ccggggacgg ctgcaggccc agttccgtca
      421 tgagcagccg gcccacccgc tcgtaggcgt gtatcgcttc cgcggggcga cctgccaggt
      481 acagggctcg gatgagcatc tcccacgctg tctctcgcag aggctggtcg gcggtcaggt
      541 cctgggcggc cgccaccgcg ccggtgtgga tcccggtctg catcagggca ccgggcctgg
      601 tcgggaatga cgagcgcgta tccgttcggc ccgctggtca gcggttgatg gggtgcgcac
      661 gtcagccctc gtggttccag cagtcggcgc aggcggctga tgtgcgcgtg gatggcggag
      721 gccgctgcgc gaggtgggtt accggcccac aggtcatcgc agagcgtctc catgccgacc
      781 gggcggccct gcgcgacgat caggcgcgtg agcagcacgc ggcactgagg cggccccagt
      841 tcgagaggcg tgccgtcgcg gctcaccgcg acgtgaccca gaagggaaaa ccgcagctcg
      901 gtatgggtca tgacgttcat gggtgcccgt gtggtcgccc ggtcggcccg gtcggcccgg
      961 tggggaatgt atgcggtgtt cgtcctcatg gccgcgtgcc gtccgtcgcg tgccaggccg
     1021 tccgcgggtg ggcctgcgcc acggccgggt ctgtcggttc cccggcgctg cccccatgct
     1081 gctgcccttc gggtgccggg ggcgcatagg cgagttggta ggggtacggg aacttgtcag
     1141 cagggggagc ggagggcgag gacaacgcac catgcggcca gcggcgccgg gcgagccaca
     1201 acactgccgc ggcgtacacg acgatcatgg tggtgtcgat ggccgccagt tgccacggca
     1261 ggtcggccgc cgtctcgtcg gagtccaacc cgccgacgaa ggccgcgccc accgcgaacg
     1321 acaccaggtt gttcagcgcg tgcagggctg tcgcagcctc cagtccgccg gtacggacgg
     1381 tcagccatcc ggcgatccca ccgaatacga cgaggtccag gaaccccgcg gtggtgcccc
     1441 agccatgcgc tgcggcgaag agcaccgcct ggggcagcac agcgatccag ggggaacgga
     1501 agaacgcgcc caccgcctgc aacagccagc cacggaacac gtactcttcg gcggccgact
     1561 gaagcggcac cagcaccacc agcatcccga ggatgggcag gtagcggtaa agaccgaccc
     1621 agacgtcgtc tccggtgccg gaggtctcgc cgacgggcag gaacagcatg gcggccatgg
     1681 tcagcgccac cacgggcacg gccaccagga cgcacagcgc cagccagcgc ttgcgcagtc
     1741 gcccttccac cgaggagatg gtgccggccg gtcgtcttcc cgcccaacgc accgtcagca
     1801 ggacgaccgg tatcgcgaca gcgagataag cgagactttg agcggtgttg acgaccgggc
     1861 cgaagtcgat accaccgtcg ccgtcttcgg gatatccctt ggccgtgccg aacccgtagg
     1921 cgaacgcgtc cgtcacgatg aacagcagta tccagcccac gatcaccatg acggtgccga
     1981 caagaggccg ccaccagcgg tggcggccgg tggcgtgggc cagccgatgg taggggtgag
     2041 gttcgcccgc agcggggaca gcgggcggag ggaggggaac aggcgctgaa aaggtcatgg
     2101 cacaaggttc cccgcggctg ccggcgatca cgtcgccccg cggcatgaac ggcgcaccta
     2161 tctctgggta gagatgatct cctaccccgg gtagatccac ccggtcgacg tgtcgatcta
     2221 ggctcgagcc caccatggac accttacgta actggctcct gccgttgatc atcccgttca
     2281 gcgccggctc gccgaccacc ccgccgtcgc ggaggcctgc gtcatcggag tgcccgacga
     2341 caagtggggc gaacggccca tgacctgcgt ggtcttcgcc gagggccggg tcggggccgc
     2401 ggaactgaag aacttcccgg gcaccgcccg tcaccggccg gcgggggtgg tgtcagcctc
     2461 cgacgcggaa gccgaggacc acgttgtggc cgccgaaccc gaaggagttg ttgagggcga
     2521 cgaggggtcc gccggggagc ggacggggcc gggaggagag cagggagggg tcgatctcgt
     2581 cgtcgcggtc ggtgatgttg atggtcgggg gcgccgtccg gtgccgcagg gccagcaccg
     2641 tggcgaccgt ctcgatacca cccgcgccgc ccagcaggtg accggtcatg gacttggtgg
     2701 cggagacggc gacatgacgc ccacccgaga gggctccgac tgcgagacat tcgtccggga
     2761 actgtacgaa caccacggca aggatctgct gcggttcgcg tcacgtctcc tgggaggcga
     2821 ctggcaccag gcggaggaca tcgtccagga ggcggccacg agggcctggc accacgtgga
     2881 gaccctgccg gtggggcagt gcgagggcct gatggccgaa cgggctctgg aacccgcccc
     2941 tttagcccgg cgatcctgcc cacaagatcg ctgactgcct ctcagggggc gtcgtatcgt
     3001 cggccggtga gcctctggac ctccctcgaa cccgcttccg ccctcgtcga ccccggcgcc
     3061 agcacgacgg tgcggcttcg ggtacgcaac accggcgaca tcgtcgacga gtaccgtttc
     3121 gaaccggtcg gcgacgtcgc gccgtgggcg accgttgagc cgcagaccct gcggctctac
     3181 cccggtacca ccggcaccgt ggagctgact ctctcaccgc cccgcagtcc cgacgccacc
     3241 gcgggggcga atccgtacgc cgtacggatc gtccccaccg tgcatcctga ggccaccacg
     3301 gtcgtcgagg gcaatctcag catcaccgcg ttcaccgagg tacgggccga actcgtgccg
     3361 cccaccgtca agggacgctt ccggggacgg ccacagctgg ccatcgacaa cctcggcaac
     3421 accaagttga cggcctccat cggttccgag aacgacgacc agctcgcgta cgacatccgc
     3481 cccgccaatg tccagatcga gcccggacgc gccgccttcg tgcacgtcac gctgaagccc
     3541 cgcgagacga tctggttcgg atcgaaggaa gaacggccct acaccctcgc cgtacggcgc
     3601 tccgggacgg acccccgcac cgtggacggc accttcgtcc agcggggctt ccttccccgc
     3661 tggctcgcca cctgcctcag cgtcgccctc gccctcgcca tcaccttcgc cgtcctgtgg
     3721 ttcggccacc agccccaggt acgcagctcc gcgacggagt ggagcgaaga ggtctccacc
     3781 accgttctcc ccagtccgga gcccccggcg agtgaactgc cgtccccgga cgcttcggat
     3841 gccgaacagg aggcgctgcc cgacggcgcc gacgacgaca ccgccgccga ccccggcggg
     3901 agttcggggg agggcggtgg ttccgaaggt tccggtggtt cgggtggctc ggccccggaa
     3961 caggaggaca aggcggcgcc cagcggaccg ctgccgtttc gccgtggtga cggtcccaac
     4021 ctcttcgttc agttcgccca ggtgaggatg gagaccgcga gggcgtccga tccgtgccgg
     4081 ctcaccggcg accaccggct cggcgtcatg gacgcggcga cggttcaggc catcaagtgt
     4141 ttccagaagg ccaacgacga gcgcaacgac ggtgtcacga tcaagacgga cggggccggc
     4201 aacctgggcc gggccaccat gacggcgctg ctgatggccc acttcggcga cagcacttcg
     4261 acccttcagc cggggaagaa gaaccccgag gtcgtctggt tgaacagcat cctgctgtgg
     4321 gccgacaacg tgcagtacga caccaacgac gtcaaggcga tggactccta cgtccgggcc
     4381 aacatccact acctgaagag cgctgacaac cgggcgagca actccgctga cggtggcttc
     4441 gccgatcgcg tcgcttccta ccagcgcaac ctgggtcttc cggcgacggg caaggtcgac
     4501 gccgcgatgt tcgccgccct ccacgcgggc aaggtcaagg gccagaacca accgggacag
     4561 gtgactgcgg ccgacttccc gcccctgccg gttgtctagt ggggcggtga ctgtcgtctc
     4621 actgtcggcc gagacatccg gcccattgaa ccgccctcga ctcgcgctcg ttgcagcgga
     4681 tgaaacaggt tcgccaggta cggggcggag atgggtgggg acgacatgat ggggacttcg
     4741 gacgacacca gggcggctga atcgactcag ccgagacgca agcgagttcc ggtcctggtg
     4801 catgcccagg accccatctc tcgcgcaggc gtcgtcagcc aactgtgcga gcatgcggtg
     4861 atcgatctcg tcgaggagaa cgaggagaac gaggagtaca ccgccccacc gggtgtgatg
     4921 gcggtggtgg ttgccgagac cctggacgac gcgaccgccg cgggactgcg caagctcgtg
     4981 cgcggcgacg gtgtccggcc cgtcctggtg gtgagtctgc tgcgcggcaa cgaactgctc
     5041 agcgccatcg agtgcggcgt cggcgccgtg gtctggcgtc gcgaggccac ggcgcagcga
     5101 cttgtgcggg ctgtcctcga cgcatcgcgc ggggacggca atcttccggc ggatctgctg
     5161 ggtcgcctca tgaaccaggt ggggatgatg caccgcggcg ccgccaacca ccccggcctc
     5221 gccccccccg gggctggggc cgcgcgaggt cgacgtgctg cggctgatcg ccgaggggct
     5281 ggacacggtc gagatcgcga gcaagctgtc ctactcgcaa cgcacggtca agggcatcct
     5341 gcacaacctc accacccgtc tgcacctgcg caatcgaagc cacgccgtgg cctatgccct
     5401 cggggagggc tacatctgac cgatcccggc gcgggcgcgc ggggcaagct tcgtcagacg
     5461 ctcgtcgtgg ccggacaggg cgcccgcatg gtccgctccg ggacgagccc gcccggacag
     5521 cctctcgttt gcccgggcgg cgagaaccac cgggtaggag agaacgccgg gtaggggtgg
     5581 gtctcgaaaa ccacctgcct gacgccgcat catcagtacg ctgcgggacg tgtgtcgtgc
     5641 ggcgtacgtt gacgcatacg acggcgacac cgggacgaca gcccggactc atgggccggt
     5701 cagacgctca tacgcggaac ggtttgctct gggtggtctc tcgggggtga ggggagcctc
     5761 ttggtggtgc atggtccacg cggtggcacg acgggtgcgg tcgaggtcgc gcggctcggt
     5821 ggtctgtggc gggtgacgcg tccctggcat ccggggttgc ggccgtttct gcgcagctat
     5881 gtcggctact gggaagcggt gacctcgccg tatgaggcgc ggttggtgcc gaccgggtgc
     5941 gcgaccctgc tgatcagcct cgcggagccg ttctcccagg tgcggcggtt gggcgtaccg
     6001 ggcgggggca gcgggaacat cgggtcgctg gtggtggggc tggaggaccg gcccgcgatc
     6061 tgtgcgcatc ccggcggcca ggaggcgatc cgggtcgagt tcacgccgct gggcgcctac
     6121 cggctgttcg gcatgccgat gagcgagttg acgaacctgg ccatcgagat ccgggacgtt
     6181 ctggggcccg aagccggggt gctggtggag cggctggcgt ccacccggga ctgggcggcc
     6241 aggttcgacc tgctggacgc ggcgttgctc gcccggctgg ggcgcggccc ggagcccgcg
     6301 cccgaggtcg gccacgcctg gcgactgctc tccggcagcg cgggggtgat cccgatcgcc
     6361 cgaatcgccg ccgaagtcgg atggagccag ggctacctga tccggcggtt cacccagcag
     6421 atcgggctga cgcccaaggc gtccgcccgg gtgctgcgct tccgccacgc cgtggcgatg
     6481 ctcagccaca gtgccgcgag cctgaccgag atctcgacgg cctgcggctt ctacgaccag
     6541 gcgcacctca accgcgagtt ccgggccatc gccggtacca cacccggaca gatggtggcc
     6601 tcccgccggg tggaaggcgc acttgctctc tcagcgagtg caaattcgtc caagaccggg
     6661 ccgcccgccg gtcgatagcg tccctgccgt aacaaccgat ggccggtcgg gcggcgcggg
     6721 ggaccgtccg gccggtcggg cccaagggga ggagccgtga ccgcgacatc agtggcggtg
     6781 ccggcccggc tcaacggggg cctgctcctc accgtcatca cctccgagca agccggcggc
     6841 ctcgcgtcag ccggagccga ggtcacctgc gcgcacggcg ccatcgcgcg caggggcttc
     6901 gtcgagcgcg cgcagggcgt acgccccgcc cgacatcacc cccgaacaga cacgagtgat
     6961 cgttcgcgag tcggccgggc cgaccgctac gacggcttca cgtaggcgca gatcgccagt
     7021 ggtgagtgcg gtgcgtacgg ttccgcgtcg gtgggccagt cgccgaagcg ggtctccggt
     7081 tcgaggccgg ccgcgcgggc gtaggcgtcc agctcctccg gtgcggtcag gcgggagacc
     7141 tcggtgccga cgcgggtggt gccgtcggac tcgtaccaga cgtgggagag gtgccacaga
     7201 gacccctcgg gcaggaggag ggagtggctc tgcaggccgg tgccgggctc cgggtagggc
     7261 gtgaagtacg tggcgcggct gcggccttcg tgcagggcga ggatggccgg cttgttgtgg
     7321 gtctccagga cgaggcggcc gccgggggcg agcaggtcgg cggcgcgctg tacggcctgg
     7381 cgctgttcct cgggtgtgag cagcatggac agggtggcgc agacgcagta gacgagcccc
     7441 acggtgcggt cggcggtgta ggtgcggatg tcggcgtgca cgggctcgac actcgtgtcg
     7501 tcggccaggt tccggcgcag gacgtcgagc atctcggggg aggagtcgat gccggtgatc
     7561 cggccgacgc ggcgcgacag cgggagcgcg atccgcccgt tgccgacgcc gaactcgacg
     7621 gtgccggaag ccggatcggg gtggagggag gccagacgct cgacctcggc gacgacggac
     7681 gcgtcgtcgg ggaacagacg gtggtaccag ccgtcgaact gccggccgta gccgatgtcg
     7741 tcgacgatgc cggtcgtcgt gggaggggat gacgtggcgg ccgtggtggt cgtggtggac
     7801 gtgctcatgg gtgctgcctc cgcttcttgg gtggggtgtt cctcgggtgg gtgttccttc
     7861 tggcctgtgc gcaggccccg aacagcgcca cgagggcggc gccgatgacg gcgggagtgc
     7921 tgacggcgcc ggtggcgatc aggaagccga cgatgccgag ggccaccacg agcggggtca
     7981 gcaggaagtc gttcatcagg tactcctgtc gggatgctct ctcctgtcgg ggtcctcgga
     8041 tcacgacgcc acgtcgctga gctcctggag ccgggcgagc cggcggtaga ggccgctgtg
     8101 ccggtggagt tcgtcgtggg tgccgacggc gtgcacctgt ccccggtcga gcaccacgat
     8161 ccgctgggcc tcggtgacgg tggacaggcg gtgcgcgatg gcgatgaccg cgcagaactc
     8221 ggagatcatg gtgatgctgt cgcgcagcgc gttctccgac tcgctgtcga ggttggcggt
     8281 ggcctcgtcc agcagcagga agcggggtgc ctgcagcaac gtacgggcga tggcgaggcg
     8341 ttgccgctga ccgcccgaca gaccggcgcc gcggtcgccg agttcggtgt cgaggccgtg
     8401 cggcagcgcg gcgatcacct ccgtcaggtt ggccatgcgc agcgcctcgg cgatgtcctt
     8461 gtcgccggcg tccggcgcgc tgtacgtgag gttctcccgg acggtgccgc gcagcagggt
     8521 gtggtcctgg tcgacgtatc cgacgatgga ccgcagctgg ttgagcggca ggtcggtgat
     8581 gtccgtgccg tcgatgcgga tcgccccgga caccgggtcg aagagccgct cgatgagctg
     8641 gaagacggtg ctcttgcccg cgccggacgg gccgacgacg gcggtgagcc cgctggcggg
     8701 caccgtgaag gagacgtcgt cgaggacgac cttctcgctg cccgggtagg cgaacgtcac
     8761 cgcgtcgaag gcgaggccgg tgttgtacgc ggtcctggcg ggccggggcc cgcgcctgcg
     8821 gtccgccggg cggtcggccg gcctctcgcc ctccacctcg atcttgccga gctccgccag
     8881 gcggtcgatc gacgccctgc cgacctggaa ctgggcgatg gacgtgaaca gcgtcagcag
     8941 cggggccacc agatagaaga gatagaggat gaacgccgtc agatcggcgg cggtcatctc
     9001 gccggtcgcg gtgcgggccg cgcccagggc gatgacgacg gtgagggcga gctgggtgcc
     9061 gatgctcatc gtcgggtcga gcagcgacga caggaccgtc accttgatcc cggacttgcg
     9121 ggcctgtttg gcgatgtccg agatgccctc cgcctcacgg gcctcggcgc gggacgcctt
     9181 cacggtcggc atcgcgccga gcacccgcat cagcgcggag ccgaagttgc cggtgtcggt
     9241 ctggttgagc accgacacct tccgcacccc gcgcgccagc cagagcgaga tgacgctggt
     9301 gacgccgaga cagcccagcg tggcgagaag cagtacctcg tcgacccagg ccatcagcgc
     9361 gataccgccg acgaccagga agccgttctg gatgatgctg tcgatggcgt gcgtcatggt
     9421 ggtgcgggcg aggagcgtgt cgctgaccat ccgggcgaac acgtcgccct gcttccagcc
     9481 gctgtacgcg cggaaccggg agcgcagcag ccgggcggcg aggttgctgc ggatgtcgta
     9541 gacgatgttc tccccggcga ggccgatgac gtacgagtgg agggcgccga ggacggcgtc
     9601 ggcgaggaac agggccgcgg cgatcaggat ggggccggtc acgggctgtt ggttttcgac
     9661 ggaggcgacc agtccgccga tgacggcggg ctgggccagg gacgccgcgg cgcccagcag
     9721 gcccagcagg atgccgagtg cgatcagtcc gcggtgtcgg cccagggctc gccacggctt
     9781 ggctcccttg ccccacagca gatgcagatg gagctcgggg accgcccggt gcacggcccg
     9841 cggcctggtc gggggccgcg tgccggcggg gttcactcgg cgtcactccc gtcgtgcttg
     9901 cgttcccgca cgacctggac gtacaggagg gccgccttga cgaagccgag gccgatcagc
     9961 acgaggccgc tgatgaagaa ggggttgtcg aggctcatgg tcaggtcctc acttcggtct
    10021 tggcaggggc gagcggggtg aggggagtgc tcggggcgtg cgggtcgagg ggcacgaagg
    10081 gggagacgaa catgagctgg gggccctggc gcatgtcgta tcccgtgctg gaggccaggg
    10141 cgaactggaa gcccctgacg tcgtcggccg acgcgtcctc ggccgcgata cgggtgcgta
    10201 cgtgctcgga gatcagccgg tagccggggg tgtgggcggc ggcggtgaag ccctggtcga
    10261 ggcggggcag gatctcctgg cacgcgtcga agacggactt gtcggcgcgg cgggtcggga
    10321 accagaccag gtgcagcggc ttgcgctcct cgatgccgct ggcgtcgcgc cagccggagg
    10381 ccgcgccgtc gccgctcacc gtccggtaca ggaagtggaa gtcgaacatg gccgggtgcg
    10441 gtgcgaagaa ccgccagttc ggcagcaggg agaagtggtc ccgggaacgg acccggccga
    10501 agtgctggtg ggggtgctgg ccggcgaggg tcagcaggag cagggcggct ccggcgatcc
    10561 gccagggggc tccctcaccg gtgaaggcgc tcttcagccg gagacggggc agggacgtca
    10621 tcgggtggcc tccttgcggg gggcggggcg ggacggacgg gaggggccag aaccggggga
    10681 gcggcggtcg ggggcgccga agaacgcgac gacgcggtcc gtcacctggt gcgcgtagcg
    10741 gctgttgatc agcatgctct cgtgggtggc gccctcgatg accacggcct cgctgcgcgc
    10801 gccgacgtgg gcctcggcga gctccttgtg gaggagaagc tgttcggggt tggtgtccac
    10861 ggtccgctgg gcggagatca cgagcgcggg tacgccctcg atccgggcga gcgctccctt
    10921 gaaggacgcg aaatcgtccc gtacggcctt ccattcgcgg cgtgcggcct cccacatgcg
    10981 ggcgtccgcg tactgcgcga agaccttctt ccggtaggcg tagggcagtt cggtgatcca
    11041 gacgggacgg gtgaggaggg cgccggtgcc caggcgcagt gcccggctga ccgaggtgaa
    11101 gtgctccgag agacccttct ccacctggct cagtccgccg gcgaactggc cggggtggga
    11161 ggagtcgagg tagacgatgc cccggagccg gtcgcccagg tgacgggcgg cgcggcgggc
    11221 gatctcgccg ccgatggagt ggccgacgag gatcacctcg cggtgcgggg cgaccgcgcc
    11281 gttcacgagg tcgaccaggt cgtgcacgga ctccgacagc cggtacgggc tggtggcctc
    11341 ccggcggctg ccggcgtatc cggcgcgggc gtaggcgacg atgccgtacc gggtctcgtg
    11401 ggccagccgt tcggagatcc aggcatagtg ctcgctcgtc gacagcagtc cactggccag
    11461 gacgacgacc ggctggtcgg ggtcgccggg cgagtactcc tcgtactgga gccggtttcc
    11521 gtgccgggtc gtcagcatgc gggaggagtg ccagccctcg gtggtacgca gccgtcgccg
    11581 tacggcggtc acggccgccg cggcggtgcc gcccgcgagt gcgacgagcg cggccttgac
    11641 ggcacggtcg tcacgtccgg cgacggcggc gtgggaccgg ggggtgctgg tgtaggcgac
    11701 cagggggtgg aatgcgggga aggcggtcac gaaccggctc aggcccatga agtagccgtt
    11761 ggccacgtgg aacgccgcgg cactggtgat catggagcgg gtcagtgtgc caccgcgggc
    11821 gtaggcgagc gggaagaggc actccagcgc gagcacgctg tgcgtgagtg ccttggcggt
    11881 cttcgggtgc tcctgggtcc agcggaagat gccttcgtga ccgtacgtac gggtgcgcat
    11941 cactccgccg agcgcggagg cgtcccgcca gggcttgccg aacagcttga cccaaccgga
    12001 caccgcgtac gccatgttgg cctggagggc ggcgtaccac accagtgcgt ccttggccgc
    12061 aggcgagggc gccagacggg cggcgccggt ggcgatctgg accagtgtgg ccacctggtc
    12121 ggagccgtcg ccgccgtagt ggtggcgcgg ggcgagcacg gcggaggagg cgcccaggaa
    12181 caggttgccc gcgccccgcc accgggaatt gccgggcagc agcatgccga cggccacggc
    12241 ggagcgggcc acgtgcaggg cggtggtggt gtgcactccg ctgacgctgt cgaccagacg
    12301 gcgtgtcagg gggccggctc cggcgaggta ctgcctggcc acctcccagt cgttcatccc
    12361 tcccttctcg atgtccttgc gctgggtcag gtactccagg gaggactgca gactggacac
    12421 ggcggccagc cgctcggaca tgccgatggc gcgatcccgg ccgaccggag ccggtccgaa
    12481 gaccgccgag gtgatccttc ccggaattac ggaaggaatt tttccggtga atttcacggg
    12541 cccctctttc gtggtaacct ctgatggatt tctttgcctc agggcacact gccgggccag
    12601 aacacgactc tggcccggca gttttcatgt gctttctcga tcagttccta acagccgcgg
    12661 ggagtgaggc tgtgcggagc ggatcagacg ccgcccacgg ccgcggcctg ggcgttcgcg
    12721 gcgttggcga tggcctggtt ggcgtccgcg gcggcgttgt tcgcctccac ggcgctggcc
    12781 gcgccgacca cctgggcgac gccgccgccg acctgggcca ggtccgccag accacccagt
    12841 gcggcgaggg cgttggcgcc gttcgcgacc cggccgatgc gcggggtacc gagggtggga
    12901 cgggcggacg cgaggatgac accctccacg gggaggtcca tacggtccat tgccttcgcg
    12961 atgatgctca ttcgcttttt cctttcggtg tgacggcttc ttttctactg cttcttttct
    13021 gcttcttctt ttcgagggct tcggggaacc tttttccgtg cccttcgaga aagaacacta
    13081 cgggcgccca caggggcctc acatcctgaa aattgccgaa tctgcgagtg acggggttca
    13141 cagtgtgcgg gcggcgcgaa aaaggcccgg accatatggt ccgggccgtt cgaaaaggcg
    13201 gttccgaaag cgggatttct cagcgaagcc ggcgcagcgc cgacgcggcc gcgttcgcgc
    13261 cgcacatgcc gtgggcgccg gctcccggtg gcgtcgcagc ggagcagatg tacatgcccg
    13321 gcacgccggt gctgtagggg tcgagcgcgg cgcgggggcg cagcacgagc tggaaggcgg
    13381 tgttcgcccc ggcgatgatg tcaccgccga cgtagttcgg gttgtactcc tcgaagccgg
    13441 ccggtgagcg gacggccatg tccaggaccc gttcgcggaa tccgggggcg aaccgttcga
    13501 tctgtgcgac gaccgcttcc gtggcgtctc cgtcgtagcc gtgcggcaca tgtgcgtacg
    13561 tccagaccgg gtggacgtcg cccttcgaac gccgcggatc ggccaggtac tgctggccga
    13621 cgaggacgaa gggccgctcg ggcatgcgcc cggcgtggat cgcccgctcg ccggcggcga
    13681 cctcctcgta ggtcccgccg aggtggacgg tgccggcccg gcgggccgcc tcgttcgtcc
    13741 agggcacacc gccctcgacg gcgaagtcga ccttgaaggc gccgggtccg tgacggtacc
    13801 ggcgataggc gcgggccacc cgcgccggca gccggtcgcc caggatgtcg gcgaccgcgc
    13861 gcggcgcgag gtcgaagagg accacgtcgg ccgggggcag gtcggcctgg gaacgcaccc
    13921 gcacaccggt ctcgatccgg ccgccgaact ccgcgagccg agccgcgagc gcgtcgctga
    13981 tcgcccggga accgcctgcg gccacgggcc acccgtggcg gtgaccggcg gcgatgatcg
    14041 tcaggccgac cgcggcgctc gccggccggt ggaacgggcg gaacgcgtgc gcggccaccc
    14101 cggcgaagag tgcgcgggtg gtctccgccc gccacagccg ggccaccgcg gcggcgggca
    14161 gcagggcctg cgggccgaac gcggccaggc gcagcggatg cttcggcaca tgaccgagcg
    14221 gctgcatcag gtcctcggcg agctcgtcgt agccgtccgc gagcggccgg aacacccgcc
    14281 gccagttgcg tccgtcccca ccgtcgaggc cgtcggccgt ctcctccacc gaccggtgca
    14341 ggaccccggc cccgccggag tccagcggat gcacgcagtc gatgtccggc aggcgccagg
    14401 tcaggccgtg gcggccgagg tcgaggccgc gcaggaacgg ggagccgacg gtcatgggat
    14461 gggtggctga gcagtggtcg tgcaggagtc ccggggtcag ctcgctggtg cgcgtgccgc
    14521 cgccgatggc gtcggcggct tcgaggacgg tgacctcgac accctcccgg gcgagaaacg
    14581 tggcggccgc gagtccgttc ggaccactgc ccaccacgac ggccgtactc atgtgcctcc
    14641 tgcgtcgcct cgaaaaacgg gcaccggtcg gccggttcgc gaagcggtga acgggaaagt
    14701 ggtggaccgg gccctcgcaa gggcccggtc cgggccgttt caccactctg cgggacgtga
    14761 gaaggccgtc ccggcgcctt ttgggtcttc gacacattag agggcgggcc cgctccggcg
    14821 cgattcgcag aattgcctaa ttcacgccct ggatcgccta acccgcatcc cagttcatgt
    14881 ccggctcggg ctccgtacgg gcattcggcc tggcgtggcg tccgtggtgc gggcgagcgg
    14941 gcggaaccgg ggcggcggac cgttcggcgt cgcgctggag ttcggcttcg gtgagcaccg
    15001 ggaaatgggc gatgagccac cagccgccgt cgtcggcggg gcccgccgtc agggagccgc
    15061 cgaccgcctc cgcccgctcg cgcagaccga tcagaccgta gccgccgtgg cctcccgtgg
    15121 gacgggagcc ccgacgctcg ggcccgtcgt tgtacacgtc gacccggagc agatcctcgc
    15181 gggtgcggtg gacgcgcacc gtcgcctggg tgcccggcgc gtgccgccgt acgttggtca
    15241 gcgcctcctg caccacgcga tggaccgcgg agcccacctc gggcagcaga gtgcttctcc
    15301 gggccgcacc ggtgacctcc agctgggcgg tggatccgtc accctggccg ctgaacgacg
    15361 agaccagttt ggtgagttcg gcgtacggct cctccgggcg ctcgatggtg gtctgctcgc
    15421 cctcctcgcg cagtacccgg atcaggcggc gcatggagtc catggtccgc tgcccggctt
    15481 cggcgatgtt gctcaggatg gggccgacct ggtggggcga gctctcgtgg atcacaccgg
    15541 cggcgtgtgc ctgcgcgatg atgcccgtca catggtgggc gacgaagtcg tgcagttccc
    15601 gggcgagttg gatccgctcg gcgagccgta ctgcggcgat cgtacggctg cgccgggcgt
    15661 ccagggtgcg caggtagcag cccgctccga cggccccgcc cacggcgaac gtcagcagga
    15721 acgggtaggt cagggtgatt ccggtgcccc cggtgcgcag gggttcgtcg atgatgctgg
    15781 cccccatcgc ggcggccagt gcgagggtga tgccgggccg ggtgacgttg cggcaggtgc
    15841 gggcgagcag gaccagcatg cacgccgtct ccagcagccc ccattcgggc agggccgccc
    15901 ccatcagcag ggtgaccagc gtcaccgtcg tcgagacggc cgcgcagact cccgcccgcc
    15961 actcggtgct cagccgcggt tccggcacga gcaccagcgc cagggcgagc gggccggtca
    16021 cgaggggcag ccagtcgacg gggccgcgct gctgtgaccc gatgatccct atgtcgagca
    16081 gccacagcac acccagagcc gggtagaggg cgcggtggtt cagccgccgc gcgggtaacc
    16141 gagaggggcc gtggtgcggc tgggtcgctc gtgccgaaag tgccgcgagt gacgaagttg
    16201 tcatacaacc ggaggttagg catgcccgtg cctgtctcac aggtggtgga tcgatctgtg
    16261 gggagggaca cagatcgacg acaggacctt cacggaacca ccgtcagtgt gccgtccgga
    16321 ccgtcccgtt ggcccaggcc cacgcggcca cctcgacgcg gttgcgcacg ccgagcttgt
    16381 ggtggatatg gcccaggtgc gtcttcacgg tggacaggga caggcacagc tcgtcgctga
    16441 tctcctggtt ggtgcggccc accgcgacca gccgggcgac gtccaactcc cgggcgctga
    16501 gcgacgattc gggcacaccg gtgccgttcg ccggcgccgc cgcccgttcc tccagccgct
    16561 tcagcagccg gaccgtcacg gcgggcgaga ccagcgcgtc accgcgcgcc gccgcccgca
    16621 ccgcctcgac cagcaacgcg ggcgtggcgt ccttcagcag gaaaccgcaa gcgccgttgc
    16681 gcagcgccac atcgaggtag tcgtcctggt cgaagctggt gaccaccacg acctgggtcg
    16741 ggtacatcgc cccggggccg gacagcagcc gggtcacctc cagcccgtcc agcttcggca
    16801 tacggacgtc caccaggcac acatccggcc gcaacgcgcg cgccagctcc acgcacgcga
    16861 gcccgtcggc ggcctctccg accacctcga tgccctcctg ggcgtcgagg atgaggcgga
    16921 atccggcccg gatcagatcc tgatcgtcgg cgatcactac gcgcgtgggg gtgctgctca
    16981 cgcggccgag catgccacgg atcacgtggc cgctccggca gtccgcggaa agccggcggt
    17041 ccgaatggct gtaaggaccg agcggttggc gcgttcctga cggccgatcc tcgtcagggc
    17101 ggaaggaccg aggtcgatcg gccgatggct accaccgggt atcggtcgaa cggtcgatgg
    17161 ccgggacccg ggtgtcacgg aagagtcaca gcgcaccagg cggacgatct cgtgggtcct
    17221 cgaccccctt cgaacaaggc aggcaccatg acagtggaca cctctggccg actcagcacc
    17281 cgggaactgg agatccttct tctggcggcc cacggtatgt cggacgcgga catgtcccag
    17341 gagctgtcga tctcgccccg cacggtggct tcccatatgc gcagcatccg ggagaagttg
    17401 tgtgcgaaga accgcacgca tctcatcgcg atagcactgc gcctgggaat cctcgcgctg
    17461 cggacggacc ggaccgaccg catgggcggt tcgaggtggc cggaccggct ggaccggctg
    17521 gatgaaacgt tccgcttgac ggggctgagc ggcggtcggg cgcagcctgt cgcctgagcc
    17581 gcccttgcca cggcaccccg gcgtcggacg gcgcaccgct gaggtggaac cgacccggtg
    17641 ccgggcgctc gccgtcctcg ccgctcagcg ccagtcgggt gtgcccgagg ccggcggcag
    17701 acgggattcg atcgtcgctc gtacctcccg catcaccgag atgatgtggg cctcgtgttc
    17761 cccggtcagc cgggccaccg ggaccgagca gctgatggcg tcggtggccg gggtgtcgta
    17821 ccgcagggcg aagccgaagc cggcgatgcc ggtgaccgtc tcctcgcggt cgatggagta
    17881 gccgcgctcg cgcacccggg ccaggtcggc gagcagcgcg gtccggctgg tgtgcgtgtt
    17941 ctccgtgagg gcggtcaacg actcgtcggt gaacggcagt tcgtcgtcgg ggcgctcggc
    18001 gagcagtgcc ttgccgaggg cgccggcatg ggccgggacg cggcggccga ccctgctgat
    18061 ggtgcgcagg tactcgtggg actcgcgggt ggccaggtag acgacgtccg ggccgtcgag
    18121 ccgtgccagg tggatcgtct cgccgagcgc gtccgacgcc tcgtcgaggt acggccgtac
    18181 cgcgcggata cgccggtcgc cgtcgagata gctggtgccg gtgagcaggg cgcggatccc
    18241 gatgccgtag agggagccgg tggcgtcggt gcggacccag ccgcagtcga cgagggtctg
    18301 gagcagctgg tacatgctgc tgcgcggcac atccaggtcc tccgcgagtt cgtccaggcg
    18361 cgagggccgc tcgccccgcg cggcgagcag ttccagcagc gcgacggtcc gcgccgccga
    18421 cttcacgcca cggacacctc tcccctccga catggcgctc atcgtaagtc cgcggcaatc
    18481 catgccggtt cacccattga ccgtctccgt tcacaccctt aacgtccatc tgcatacgtg
    18541 gacagcatct gcatacaggg atggatctca ccagctcgcc gccccgcacc ggttcaaagg
    18601 agaactgtca tgcccctgct cgtggtgggg atcagtgtgc tgatcctgct gctgctcatg
    18661 accaggctga ggctgaacgg cttcgcggcc cttctgctcg tggcggtcgg cgtcgcactg
    18721 gtccggggaa tcccggtggc gaccatcccc gacgtgctct ccgagggcat cgggggccag
    18781 atcggcgaca ccatgctcac catcggactc ggtgccatgg tcgggcgggt gatgggggac
    18841 tccggtgccg cgcagcggat agccggaaag ctcctcgacg cgttcggccc ccgctgggtc
    18901 caggtggcca tggtggtcac gtccatgttg atcggcgtga ccatgttcta cgaggtcgcc
    18961 ttcatcatca tcgtgcccat cgcgttcacc ctggtcaggg tcaccggggc gaagctgctg
    19021 tgggtcggtc tgccgatgtc catcgcgctg tccaccatgc acagcttcct gccgccgcac
    19081 cccggcccca ccgccgtcgc cgcgaccttc cacgcctccg tcgggctgac gctgttctac
    19141 ggcctgttca tcgccgttcc cgccggtgcg ctcatcgccc tgacctggcc ccggcttccc
    19201 ttcgtcaggg cgctggaccc ggccatcccc aagggcctgg tcaccgagcg cgagttcacc
    19261 gacgaggaga tgcccggcct cggctggtcg ctgttcgtgg cgctcttccc cgtggtgctg
    19321 atcgtggccg ccgccgtgac cgacatggcc acctccaccg agagcccgct cctgaactcc
    19381 gtcgccttcc tcggctcggc accgatcgcg ctgctgctca ccctgtgcct ggcgatctgg
    19441 gcgttcggac cgcggatcgg ccggagcctg gaggaggtcg gcgcctcctg cacctcggcg
    19501 gcgaaggcga tggcgatgat cctcctggtg atcggcgcgg gcggggcctt caagaacgtc
    19561 ctcgtcgaag gcgggatctc cgactacatc aaggacgcca cggacagttg gtccatctcg
    19621 ccgatcgtcc tggcctggct cgtcgccgtc atcctccgta tcgcgctcgg ctcggcgacg
    19681 gtcgccgtcg tcacggcctc cggcgtggtg ctgccgctgc tggcgggcag cggggtccac
    19741 ccggagatga tggtgctcgc cgtcgcctgc ggttccatcg cctgctccca tgtcaacgac
    19801 cccggattct ggctgttcaa ggagtacttc aacctctccg tcatcgaagc gatcaaggtc
    19861 cgtaccagct atacgaccgt gctcgcgatc ctcggcctgg gcggtgtcct ggcggccgag
    19921 tgggccctcg acgtcctcag cctgtaaccc gactcatcca tgacacaagg gacttggacc
    19981 agcatgagca gtcagccgac cgtcaccgag tacgccgtct accctgtcgc cggccgcgac
    20041 tgcatggagc tgaacctctc cggcgcccac ggcccgtact tcacccgcaa cgtcgtcgtc
    20101 ctcaaggact ccgagggccg tacgggactg ggggaggtgc ccggcggcga gaagatcacg
    20161 cagacgctcc gcgacgccgg acccctcgtc ctcggggcga aggtgggcga ctacaagcgc
    20221 gtcctccgcg agatcggcga ccgtttcgcc gaccgcgacg ccggcggccg gggcgcccag
    20281 accttcgacc tgcggaccac cgtccatacc gtcaccgccg tcgagtcggc gctgctcgac
    20341 ctcctcggcc agcacctcga cgtgcccgtg gcggcgctct tgggcgacgg gcaacagcgg
    20401 gattccgtac gggtgttggg ctacctcttc tacgtcggcg accccgaccg gaccgatctg
    20461 gagtacgtcc gcgaacccga cgtggacgcg gagtggcacc ggatccgaca cgaggaggcc
    20521 ctgaccccgg aggcgatcgt ccgccaggcc gaggcggtct acgacctcta cggcttccgg
    20581 gacttcaagc tcaagggagg cgtcctggaa ggcgcggagg a
//
