LOCUS       NZ_CP102512            20984 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces sp. CA-210063 chromosome, complete genome.
ACCESSION   NZ_CP102512
VERSION     NZ_CP102512.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CA-210063
  ORGANISM  Streptomyces sp. CA-210063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10859970)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Jorgensen,T.S., Klitgaard,A.K.,
            Mourched,A.S., Blin,K., Oves-Costales,D., Genilloud,O., Larsen,T.O.,
            Tanner,D., Weber,T., Gotfredsen,C.H. and Charusanti,P.
  TITLE     Identification of the Biosynthetic Gene Cluster for Pyracrimycin A,
            an Antibiotic Produced by Streptomyces sp
  JOURNAL   ACS Chem Biol 17 (9), 2411-2417 (2022)
   PUBMED   36040247
REFERENCE   2  (bases 1 to 10859970)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Assembly Name                     :: M642_aaa1.6.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 55.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 11:12:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,501
            CDSs (total)                      :: 9,410
            Genes (coding)                    :: 9,051
            CDSs (with protein)               :: 9,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 141 of 359
            Pseudo Genes (incomplete)         :: 302 of 359
            Pseudo Genes (internal stop)      :: 23 of 359
            Pseudo Genes (multiple problems)  :: 101 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8596389
            Orig. end                         :: 8617373
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102512.1.
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20984
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="28"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20984
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20984
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10984](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10984)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    554..567
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    complement(1019..1034)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.48"
                     /tool="antismash"
     gene            complement(1632..2249)
                     /locus_tag="JIX56_RS37580"
                     /old_locus_tag="JIX56_37580"
     CDS             complement(1632..2249)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117702.1"
                     /locus_tag="JIX56_RS37580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37580"
                     /product="urea amidolyase associated protein UAAP2"
                     /protein_id="WP_257551333.1"
                     /transl_table=11
                     /translation="MKTVVPARAAWSSVLRTGETLTLTDLHGNQAVDFLVYDAHDTSVR
                     YSAPDTIHAQGGIFLTTGSVLMSNEHTPLMTVVADDVGRHDTVGGACSKESNTLRYGHH
                     TWSQHACVDNFLAEGAKHGLGKRDLVSNINWYMNVPVEKDGTLGIVDGISAPGLALTLR
                     AECDVLVLVSNCPQINNPCNGFDPTAVEMTVDAPADSRGDRE"
     gene            complement(2282..3106)
                     /locus_tag="JIX56_RS37585"
                     /old_locus_tag="JIX56_37585"
     CDS             complement(2282..3106)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327016.1"
                     /locus_tag="JIX56_RS37585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37585"
                     /product="urea amidolyase associated protein UAAP1"
                     /protein_id="WP_257547337.1"
                     /transl_table=11
                     /translation="MATSTTYGARDHARAQEGVRTEAMPVVPASSWPTPPREADRLVWA
                     ETVAGGNYTHRVLARGTEFRLTDLRGDACAHLLLHHADRPWERLNVADTVKVQWNAYLG
                     EGVLLLSDQGRVLASVVADTSGRHDALCGTSTLVRNTERYGDGTPQSPSPAGRELFKLA
                     AAKNGLEPRDLPPSLSFFQGVRVREDGTLDFTGSAGPGARVTLRAEQDVTVLIANVPHP
                     ADPRPEYVSTPLEVLAWRAEPTRPGDPLWDATPEGRRAFLNTAEFLAARGIA"
     gene            3299..3934
                     /locus_tag="JIX56_RS37590"
                     /old_locus_tag="JIX56_37590"
     CDS             3299..3934
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114420.1"
                     /locus_tag="JIX56_RS37590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37590"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_257547339.1"
                     /transl_table=11
                     /translation="MGSVEGTGGRRVGRPRAERRPESGLSPRDELLAAAAELFTTRGYA
                     ATTTRAVAERAGLRQASMYHHVSGKEELLAELLESTVTPSLTCARELLARDAVPAERRL
                     WELCRADVALLCGGPHNLGGLYLLPEVRAERFAGFHAVRAELKDAYRQLIASTAAGGAL
                     AKSELDLRTDLVFGLIEGVILVHRSDPDRSVSAFAEATADAALRIAGV"
     misc_feature    4176..4189
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.8"
                     /tool="antismash"
     misc_feature    complement(4177..4190)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.31"
                     /tool="antismash"
     misc_feature    4177..4191
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.52"
                     /tool="antismash"
     gene            4290..5939
                     /locus_tag="JIX56_RS37595"
                     /old_locus_tag="JIX56_37595"
     CDS             4290..5939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013004893.1"
                     /locus_tag="JIX56_RS37595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37595"
                     /product="ATP-binding protein"
                     /protein_id="WP_257547341.1"
                     /transl_table=11
                     /translation="MVSVQKPPGGRELPYARVLPLPAILMAAATGITVSLVTGPARLAV
                     GLCGAVATLLLIVVAVVAVRGGRRTVRGLRGEQERQTAFLEQRIAAHDQEFTRLGKEIL
                     PAALYRLRGGESPPEVIRHVVDGDAEWRELPESQRDLLQTVLTIVDREEALRDSSQRSF
                     VNIARRVQAIVHQQNKELREMEEDHGRNPEVFDDLLRIDHGTALIGRLADSIAVLGGSR
                     PGRVWPRPVPLYSVLRGAMSRILEYRRIELDSIAKVNVNGVSVEPVIHACAELLDNATR
                     YSPPHTKVHVTAVEVQTGIAIEIEDGGISLGEENRAKIEDMLAKAQQGLDIQDMSGSPR
                     LGLAVVGRLSTMYNMQISLRPSAYGGVRAVVVVPRDMLTDEPAPGLAHGIGAAAVPTMD
                     TGGVEGPNRKAKRRRPTTGPRIPSSAEEMGRDLEDDVPVVTEWTANGLPQRRSRMTIPL
                     SQRYAEAAAAEAAAEAAIAASPVWQPEPEPEKELPPPGMWVEAFMAGLKGDPDPAALTQ
                     NPDDPDESTGITALTTNNESARTDTDDEGDLK"
     gene            5936..6343
                     /locus_tag="JIX56_RS37600"
                     /old_locus_tag="JIX56_37600"
     CDS             5936..6343
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549147.1"
                     /locus_tag="JIX56_RS37600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37600"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_257547343.1"
                     /transl_table=11
                     /translation="MIQQRANFDWLLKDLADGVPGIQQIVVLSADGLRIARYGGDADAA
                     DRVAAACAGLQSLAGAVASEIPQSDGHMRMVIIQINGGYFYLMAAGSNAYLAVLANEIA
                     EPGLMSNRMRDLVDRIGSHLTSPPRRNGQTV"
     gene            6340..6753
                     /locus_tag="JIX56_RS37605"
                     /old_locus_tag="JIX56_37605"
     CDS             6340..6753
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485263.1"
                     /locus_tag="JIX56_RS37605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37605"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_257547345.1"
                     /transl_table=11
                     /translation="MTPPRRQRRQPKHEPPAPPPPLDAPTSGTGERPPERLYILTGEDG
                     ERAPIDLVTLIVACADAPPSAAPEQSALLRICQAPLSVAEISAYLNLPISVVTVLLTEL
                     LTAELVQARAPVVRQARADRSLLEAVMHGLQKL"
     misc_feature    6502..6504
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6734..7357
                     /locus_tag="JIX56_RS37610"
                     /old_locus_tag="JIX56_37610"
     CDS             6734..7357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013004896.1"
                     /locus_tag="JIX56_RS37610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37610"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_257547347.1"
                     /transl_table=11
                     /translation="MDFKSSDTITGPRTEDHLPHTAQAAAKIVIVGGFGVGKTTMVGSV
                     SEIRPLTTEETMTQAGIGVDDNFGSKTKTATTVAMDFGRISITDELVLYLFGTPGQERF
                     WFLWNGLFEGALGAVVLVDTRRLEVSFDVMGRLEERGVPFVVAINDFPDAPRYAIEELR
                     QALDLPEELPILRCDARRRASSRDVLMTLMRFLHSLTMSGSASA"
     gene            7490..8968
                     /locus_tag="JIX56_RS37615"
                     /old_locus_tag="JIX56_37615"
     CDS             7490..8968
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380986.1"
                     /locus_tag="JIX56_RS37615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37615"
                     /product="cytochrome P450"
                     /protein_id="WP_257547349.1"
                     /transl_table=11
                     /translation="MTPESHSLTGTADPTPGPPPGCPAHGMGPGGLRRLYGPEAEDLGA
                     VYEKLRAEHGPVAPALLHEDVPIWVVLGHAENLHMVSTPSQYCKDSRSWTPMLDGTVKP
                     DHPLMPHFAWQPICAHAEGDEHLRLRGAVTGAMSTIDHRGIRRHINRATQHLVNQFCED
                     GRADLVGQFAEHLPMAVMCEILGMPEEYGDRLVQAARDCLKGSETALASHAYLMEVLSR
                     LAVRRRAQPQEDFTSHLVTHPAGLTDEELREHLRVVLLASYEATANLLANVLRMVLTEP
                     GFRAQLNGGQMTVPEAVEQSLWDEPPFSTVFAYFAKQETELGGQRIRKGDGLLLGMAPG
                     NVDPRVRPDLKANMQGNRSHLAFSGGPHECPGQDIGRAIADVGVDALLARVPDIQLACA
                     EHELRWRSSVSTRHLVELPVKFEPKSPQEIMERPTVKPVPSQRANNWQVGREQPQPTAP
                     EPAVPADEPTPASAPEPAGRPGVFRRLLRWWRGN"
     gene            complement(8987..9928)
                     /locus_tag="JIX56_RS37620"
                     /old_locus_tag="JIX56_37620"
     CDS             complement(8987..9928)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1279: pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661671.1"
                     /locus_tag="JIX56_RS37620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37620"
                     /product="RluA family pseudouridine synthase"
                     /protein_id="WP_257547351.1"
                     /transl_table=11
                     /translation="MRRRTPPPPSPLPQRDGVDPVRVRLPTGDTWATVRDYLVARLPAR
                     AGLIDNMLDEGHIVDATGRPVPWDMAYVPGMFVWFHRDLPDEERVPFTVDVAYRDEHVV
                     VADKPHFLATTPRGSHVAETALARLRRQLGIPTLSAAHRLDRLTAGLVLFTVRPKERGA
                     YQTLFRDRRVAKEYEAVAPYDPALVLPRTVRSRIVKERGVPAAYEVEGEPNAESRVELL
                     EHRNGRARYRLTPSTGQTHQLRVHMSALGVPILGDPLYPVVTGPVAAGDFRRPLQLLAR
                     VLEFTDPVTGREHRFVSPRVLRAWPSYEEWAG"
     gene            complement(10001..10984)
                     /locus_tag="JIX56_RS37625"
                     /old_locus_tag="JIX56_37625"
     CDS             complement(10001..10984)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064917.1"
                     /locus_tag="JIX56_RS37625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37625"
                     /product="terpene synthase family protein"
                     /protein_id="WP_257547352.1"
                     /sec_met_domain="T1TS (E-value: 8e-49, bitscore: 166.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPSLRALYTWQGNPSVDLLNRDGDVWTYNMGLLPLAADPDEWE
                     AIGLADITAWCYPFAEEDELFLAYHLYAWMFALDLLFVRTFKAERDLTGARAMVDRLSA
                     FMPLDGTSRAIPDHPIERSLADIWLRMTPTRSAAWKRNMLNAVMEYADGQCWELECMCT
                     GRIPDPAEYLVRRRGSFGGHVGICLAEHVAAAEVPARVRQSRPFRALMDAWTDLQTLYN
                     DVRSYRREVEKEDETCNFVLVFARFLDISVDEAAALVTRLRAARQSEYEYLESTRLPAL
                     CEQLQLNGNDREQLSAVLEAMRYHLAAVDVWTTIAPRYQAPAPGDA"
     gene            complement(11554..13119)
                     /locus_tag="JIX56_RS37630"
                     /old_locus_tag="JIX56_37630"
     CDS             complement(11554..13119)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064918.1"
                     /locus_tag="JIX56_RS37630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37630"
                     /product="amino acid permease"
                     /protein_id="WP_257547354.1"
                     /transl_table=11
                     /translation="MTSTAPDVRPEPPHSPDDRSLTEFGYRQELHRSLNRYASFAAGFS
                     FISVLTTVFQFFAFGYAFGGPVFFWTWPAVLIGQLLVAACFAELAARYPISGAIYQWSS
                     RLSTQTFGWFAGWIMVIGQIVVVAAAALALQMVMPAIWSGFQLVGGDPTPTSATGAANA
                     AVLGVILLVLTTVVNLLDNRVLSVVNRVGVTAEIIGAILIVVLLLTHSERSPGITFHTA
                     EGSTDLLGALLVGSFMAAYVMIGFDSAGEMSEETHHPRRTAPRTILTALGAAGLLGGLL
                     VLAGLLAAPSLTDGRLGVEGLSYVLTSSLGDGLGRFLLADVVVAITVATLAIQTSACRM
                     LFSMARDGQLPFAGRLAKVNARTGMPTAPAVVVGLLAAALLLLNFASPEAFLAIGTTCI
                     VMLYLAYAMVTGPLLVRRLKGTFASDGTDETGKPLFSLGRWGVPVNALALLYGLFMTVN
                     LAWPRAAVYDPAGGHWYFQWFTVLFLLVTVVLGVLYRLMRSRRVRSAAEPARALADPAQ
                     LPPQ"
     misc_feature    13085..13099
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.9"
                     /tool="antismash"
     misc_feature    13274..13289
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.28"
                     /tool="antismash"
     gene            13380..14195
                     /locus_tag="JIX56_RS37635"
                     /old_locus_tag="JIX56_37635"
     CDS             13380..14195
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114424.1"
                     /locus_tag="JIX56_RS37635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37635"
                     /product="N-formylglutamate amidohydrolase"
                     /protein_id="WP_257547356.1"
                     /transl_table=11
                     /translation="MNDASPSYRFLPGAPESPVLLHVPHSSRVIPAAVRDGIVLDDAAL
                     ERELDHITDGHTDRIAEQAADRSAVRPWRFVNQLSRLVIDPERFPDEREEMLAVGMGAV
                     YTRTTHGEVLRAAGPDGLPLGGQPLIDGYFHPYADAMTDAVTDRLDAVGRAVVIDVHSY
                     PTGPLPYELHGDGPRPPVCLGSDAFHTPPGLLGAAEDAFAGFGGTGVNSPFGGAYVPLT
                     YYGHDRRVTALMIEIRRDVYMAEPGGAAGPGLGRLADALARLVDVLTSA"
     gene            complement(14182..15816)
                     /locus_tag="JIX56_RS37640"
                     /old_locus_tag="JIX56_37640"
     CDS             complement(14182..15816)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327027.1"
                     /locus_tag="JIX56_RS37640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37640"
                     /product="serine hydrolase"
                     /protein_id="WP_257547358.1"
                     /transl_table=11
                     /translation="MGVRHARTHHRSRTRGATALASLLVLGCVPYGIGTVSAAPPPQPP
                     PQLTQEDVDRAVDALDGIVERGMDRTGVPGVAVAVVYQDRVVHLDGYGKRHVGQDAEVG
                     PDTVFQLASLSKPLASTVVAGAVGDKTVDWDDPVSEHLPSFALKDPWVTDHVTIADLFS
                     HRSGLPDHAGDLLEDLGYDRDYVLEHLRLEPLTPFRASYAYTNFGVTAAGEAVADAAGT
                     SWEKLAEDTLYKPAGMDATSSRFNDYEAATDKAFAHVRDGDTGDDDTGTGTGTGTWEAR
                     HVRDADAQSPAGGASSTVRDLSLWLRLQLANGELDGDRVIAADPLERTHVPEIVSQPPP
                     APAGRAGFYGLGWNVSYDDLGRLRLSHSGAFALGANTNVMMLPGEQLGIAVLTNGEPVG
                     LADAVSLDFLDTAQHGKPTEDWLDLAGRLYEQEAQKSRSPTDYGKPPEDASDARADATY
                     TGTYTNAYYGPLTVTKTGGDLTMRLGPKPMTFRLTHYAGDTYFFETVGENASGPSGVTF
                     KGDANGKATEVTIEAFDETGLGTFRRS"
     gene            complement(16241..17086)
                     /locus_tag="JIX56_RS37645"
                     /old_locus_tag="JIX56_37645"
     CDS             complement(16241..17086)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /GO_process="GO:0055072 - obsolete iron ion homeostasis
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200: vibriobactin
                     utilization protein ViuB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019986124.1"
                     /locus_tag="JIX56_RS37645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37645"
                     /product="siderophore-interacting protein"
                     /protein_id="WP_257547360.1"
                     /transl_table=11
                     /translation="MAERPVRRTPKPHSGRVVRTERLTPHMQRVVLGGDGLAEFSPRGS
                     TDHYVKLLFGPEGMTYPEPFDLERIRAEFPRDQWPVTRTYTVRAWDPGLRELTIDFVLH
                     GDEGLAGPWATRVQPGELVRFLGPGGAYAPNPEADWHLLVGDESALPAIGASLEALPDG
                     ARVHALVEVAGPEEEQKINSDVDVVWLHRGDRPIGAALVEAVRALEFPEGRLHAFVHGE
                     AGFVKELRRLLRVELSVPREDLSVSGYWRLGHDEDGWQAAKKEWNARVEAEQDGVSATA
                     "
     gene            complement(17261..18190)
                     /locus_tag="JIX56_RS37650"
                     /old_locus_tag="JIX56_37650"
     CDS             complement(17261..18190)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988114.1"
                     /locus_tag="JIX56_RS37650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37650"
                     /product="5'-3' exonuclease"
                     /protein_id="WP_257551334.1"
                     /transl_table=11
                     /translation="MRGVTRRLMLLDTASLYFRAYFGVPDSVKAPDGTPVNAVRGLLEF
                     IDRLVRDHRPTDLVACMDADWRPQWRVDLIPSYKAHRVAEEHEVGPDEEEVPDTLSPQV
                     PVIEEVLDALGIARVGVAGYEADDVIGTFTARAKDPVDIVTGDRDLYQLVDDGRGVRVL
                     YPLKGVGSLQLTDEAWLREKYGVDGRGYADLALLRGDPSDGLPGVPGIGEKTAAKLLDQ
                     FGDLAGIMAAVDDPAAKLTPSQRKRLDEARPYVAVAPTVVQVAADVPLPEVDTALPRAP
                     RDPAALEELAARWGLGGSLQRLLTTLQA"
     misc_feature    complement(18299..18314)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.95"
                     /tool="antismash"
     gene            18483..19583
                     /locus_tag="JIX56_RS37655"
                     /old_locus_tag="JIX56_37655"
     CDS             18483..19583
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988115.1"
                     /locus_tag="JIX56_RS37655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_37655"
                     /product="glycine betaine/L-proline ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_257547362.1"
                     /transl_table=11
                     /translation="MSARESSRLEAEGLYKVFGRRPDDAVDRLRAGADREELRAEGTTA
                     AVIDASFTVEPGQIFVVMGLSGSGKSTLLRMLNGLLEPTAGHVRFDGRDLTALSDRELR
                     AVRAGSISMVFQHFALFPHRSVLENAAYGLEVQGVPRAERVRRATEALGLCGLAGWETS
                     WPDELSGGMQQRVGLARALATDADLLLMDESFSALDPLIRRDMQDQLLELQQTLKKTIV
                     FITHDLNEAMRLGDRIAVMRDGRIVQTGTAEDILIRPADDYVASFTQDVDRSRVLTAGA
                     VMDTAVRGDEADCGCETATPGTPFTELCAISARLSHPVAVLDKQGALVGVVPRHRLIGF
                     LGDQQVEPTPCDAPRDKAVRAVKASA"
     misc_feature    19616..19631
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.92"
                     /tool="antismash"
     misc_feature    19670..19685
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.93"
                     /tool="antismash"
     misc_feature    20293..20307
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 gggcaccgtc accggctccc accgcgcgac cggtgagccg tccacggtca ccggggcggg
       61 ggcgcccgtc acacagaccg tggtggcgtg ggtgaagcgg agggacggcc cctggagggt
      121 gcattcgagg ccgggggcgc cctcggggtt gccgagcgcc cggttgccga ggcggaagga
      181 gaggtcgtcc atggggccgc agggcgggac gccgacctgc cagtagccgg tacggccggg
      241 ccagtcctgg acggtggtga gggtgccgcc cgagacgacc tcgatccggg gggtcgggtc
      301 ggtcacggac gcgagggtgg ccgtggtgtg ggtggcctgc cggaagtccc ggtcgtcgag
      361 ggccgcccgg agctggccca ggttggtctc gatgccgtcg acgcgggtcc gggccagcgc
      421 ctcgtcgagc cggcgcaggg cgtgggcgcg gtcggagccg tgggcgacga ccttggcgag
      481 cagcgggtcg tacgccgtgg tgacctcggt gcccgtctcc acccagccgt ccacgcggac
      541 gtcctggggg aactcgaccc gggtcaacag gcccgcgctc ggccggtgtg cacgcgaggg
      601 gtcctcggcg tagacgcggg cctcgacggc gtgcccgagg ggttgggccg gggcctgtac
      661 gacggcggag tcgccgcgcg ccaggcgcag catccaggcg acgaggtcga cgccgtagat
      721 ctcctcggtg accggatgct ccacctggag gcgggtgttg acctccagga agtacgcctc
      781 ctcgcgcgcg gcgtcgtaga cgaactcgac ggtgccggcg gagcggtact cgacgctcgc
      841 gcacaggtcg cgggcagagg cggtcagtcg cgcgcggacg tggtcgggga ggccgggggc
      901 cggggcctcc tcgacgacct tctggttgcg gcgctggagg gtgcagtcgc ggtcgccgaa
      961 ggtgacgacg aggccgtcgc cgtcgccgaa gacctgcacc tcgacatggc gggcccgctc
     1021 gacgaggcgt tcgagataga cacctgacga ggccgcggag aaggaggcgg cggcgatgcg
     1081 ccgcacccgg tcccaggcct cggtcagttc atcggcggaa cgacatgccg acataccgat
     1141 accaccgcca ccgccggtgg ccttgagcat caccggatag ccgatggccg aggcctggtc
     1201 gagggcttcg gcgagggaag gcagcaggtc ggtgccggga aggagcggaa cgcccgcggc
     1261 ctcggcggcc gcgcgtgcgg tgtgcttggc gccgaacagc tccaactggt cgggggtcgg
     1321 gccgacgaac acgatgtccg cgtccgcgca gcggcgggcg aaggccgcgt cctcggagag
     1381 gaagccgtag ccggggtgga tggcgcccgc gcccgtgtcc ttggcggcct tcaggaccag
     1441 gtccgtgtcg aggtacgact ccttcgcggg tgccgggccg agccgcaccg cctcgtcggc
     1501 gagccggaca tgggcggcgg cgcggtcggc gtcggagtac acggcgaccg tacgcaggcc
     1561 cagtgcgcgg gcggtgcgga tgatccggac ggcgatctcg ccccggttcg ccaccagcag
     1621 cgtgtcgaag gtcattcccg gtctcctcgg ctgtcggcgg gcgcgtcgac ggtcatctcc
     1681 acggccgtcg ggtcgaagcc gttgcagggg ttgttgatct gggggcagtt ggagaccagc
     1741 acgagcacat cgcactcggc gcgcagggtc agggcgaggc cgggggcgga gatgccgtcg
     1801 acgatgccga gggtgccgtc cttctcgacc ggcacgttca tgtaccagtt gatgttcgac
     1861 acgaggtcgc gtttgccgag gccgtgcttg gcgccctccg cgaggaagtt gtccacgcag
     1921 gcgtgctgcg accaggtgtg gtgcccgtac cgcagcgtgt tcgactcctt ggagcaggcg
     1981 ccgccgaccg tgtcgtgccg gcccacgtcg tcggcgacca cggtcatcag cggggtgtgc
     2041 tcgttggaca tcagcacgct gccggtggtg aggaagatgc cgccctgggc gtggatcgtg
     2101 tcgggcgcgc tgtagcggac ggatgtgtcg tgggcgtcgt agacgaggaa gtcgacggcc
     2161 tggttgccgt gcagatcggt gagggtgagg gtctcgccgg tgcggagcac ggacgaccag
     2221 gccgcccggg ccggaacgac ggtcttcatg cggtccccgg tctccgtacg attcccggtc
     2281 ttcatgcgat ccccctcgcg gcgaggaact cggcggtgtt caggaaggcg cggcggccct
     2341 cgggggtggc gtcccacagc gggtcacccg gtcgggtcgg ctcggcgcgc caggcgagca
     2401 cctccagcgg ggtgctgacg tactcggggc gcgggtcggc cgggtgcggc acgttggcga
     2461 tcaggacggt cacgtcctgc tcggcgcgca gggtcacacg ggcgccgggg ccggcggagc
     2521 cggtgaagtc gagggtgccg tcctcgcgta cccgcacccc ctggaagaag gacagcgagg
     2581 gcggcaggtc ccggggttcg aggccgttct tggcggcggc cagcttgaac agctcacggc
     2641 cggcggggga gggcgactgc ggggtgccgt ccccgtaccg ctcggtgttg cggacgagcg
     2701 tggaggtgcc gcacagcgcg tcgtgccggc cggaggtgtc cgcgacgacc gaggcgagga
     2761 cgcggccctg gtcggacagg agcagcacgc cctcgccgag gtaggcgttc cactggacct
     2821 tgaccgtgtc cgcgacgttc agccgctccc aggggcggtc ggcgtggtgc agcagcagat
     2881 gcgcgcacgc gtcgccgcgc aggtcggtca gccggaactc cgtgccccgg gccagcaccc
     2941 ggtgggtgta gttcccgccc gccacggtct ccgcccacac cagccgatcc gcctcgcggg
     3001 gtggtgtcgg ccagctgctc gccgggacca cgggcatcgc ctcggtccgg acgccctcct
     3061 gagcgcgggc gtgatcacgt gctccgtacg tcgtcgatgt cgccatcgtc ggacctccga
     3121 gtgcggtgcg tatttctgtc gtccgacaga aattaggtcg ggggcgggtc gccgccatgt
     3181 cccgtgcgtt gcgcggcggt taccgagctc tcacgaatgg tcgtgcctcg tcagggctcc
     3241 ggtgaaccgc gcgatcggtc acacgggctc gcgggcgccg tgtgcgagga tcgaacgcat
     3301 gggcagcgtg gagggcacgg gtgggcggcg cgtcggcagg ccccgggccg agcggcggcc
     3361 ggagagcggc ctgtcacccc gcgacgaact gttggccgcc gccgcggagt tgttcacgac
     3421 acggggctac gcggccacca ccacccgggc cgtcgccgag cgcgccggcc tgcggcaggc
     3481 ctccatgtac caccacgtct ccggcaagga ggagctgctc gccgagctcc tggagtccac
     3541 ggtcacaccg tcgctcacct gcgcccggga actcctcgcc cgggacgccg tccctgccga
     3601 gcgacgactg tgggagttgt gccgcgccga cgtcgccctc ctgtgcggcg gcccgcacaa
     3661 cctcggcggc ctctacctcc tcccggaggt ccgcgccgaa cgcttcgccg gcttccacgc
     3721 cgtacgggcc gaactcaagg acgcctaccg gcagttgatc gcgtcgacgg ctgcgggcgg
     3781 ggcactcgcc aagagtgagc tggatctgcg taccgacctg gtcttcgggc tgatcgaggg
     3841 cgtcatcctc gtccatcgct ccgaccccga ccgctccgtg tccgccttcg ccgaggcgac
     3901 ggcggacgcc gcgctgcgca tcgccggcgt ctgaggaaaa cgcccccggc gtccttcggc
     3961 gccccgcctc cggcgccggt tcaccccggc aagaggttct tttcgtacac ccgtgcatcg
     4021 tcacgcattg tgtgcgaatg acctcccagc gtgtaaatca ccagagcgta ctcctgtcct
     4081 gagagtgatt tcagacggtt gctgaatatg acgcagcgat gatccggtcg gactaagctc
     4141 gcccgcagcg caccgagttg aggtgtattc gtgcgcttgt tccagaaaat accgaagatc
     4201 cagtttgaat cggtgatgaa ccccaacaac ccacagcatc tccccgcaag tcccccgacc
     4261 ttcagccgaa ctgtctttag agggcataca tggtgagtgt tcaaaagcct cccggtggcc
     4321 gtgaacttcc ctacgcgcgc gtgctgccgc taccggcgat actgatggcc gcggcgaccg
     4381 ggatcaccgt ctccctggtg acggggccgg cccggctcgc cgtcggcttg tgcggagccg
     4441 tcgcgacgct cctgctgatc gtggtcgccg tcgtcgcggt gcgcggcggc cgtcgtacgg
     4501 tccgcggact acgtggcgaa caggagcggc agaccgcctt cctcgaacag cggatcgccg
     4561 cccacgacca ggaattcacc cggctgggca aggagatcct gcccgccgcg ctgtaccggc
     4621 tgcgcggtgg agaatccccc ccagaggtga ttcgtcacgt cgtcgacggt gacgcggagt
     4681 ggcgcgaact gcccgagtcc cagcgagact tgctgcagac ggtgctcacc atcgtcgacc
     4741 gcgaggaagc gctgcgcgac tcctcgcagc ggtccttcgt caacatcgcc cgtcgcgtcc
     4801 aggcgatcgt ccaccagcag aacaaggaac tccgggagat ggaggaggac cacgggcgca
     4861 accccgaggt cttcgacgac ctcctgcgca tcgaccacgg cactgcgctg atcggccgcc
     4921 tggccgactc catcgccgtc ctcggcggca gccgccccgg ccgtgtctgg ccccggcccg
     4981 tccccctgta cagcgtgctg cgcggcgcca tgtcccgcat cctggagtac cgccgcatcg
     5041 agctcgactc gatcgccaag gtcaacgtca acggcgtctc cgtcgaaccg gtcatccacg
     5101 cctgcgccga actcctggac aacgccaccc gctactcgcc gccccacacc aaggtgcacg
     5161 tcaccgccgt ggaggtgcag accggcatcg ccatcgagat cgaggacggt ggcatcagcc
     5221 tcggcgagga gaaccgcgcc aagatcgagg acatgctggc caaggcccag cagggtctgg
     5281 acatccagga catgagcggc agtccgcgcc tcggcctcgc cgtcgtgggc cggctgtcga
     5341 cgatgtacaa catgcagatc tccctgcggc cgtccgccta cggaggcgtc cgcgccgtcg
     5401 tcgtcgtccc ccgcgacatg ctcaccgacg agcccgcccc cggcctcgcc cacggcatcg
     5461 gcgccgccgc cgtaccgacc atggacaccg gcggtgtcga aggccccaac cgcaaggcca
     5521 agcgtcgccg cccgaccaca ggaccgcgga tcccgagctc cgcggaggag atgggacggg
     5581 acctggagga cgacgttccc gtcgtcaccg agtggacggc caacggcctg ccgcagcgtc
     5641 gcagccggat gacgatcccg ctcagccagc gctacgccga ggccgccgcg gcggaggccg
     5701 ccgccgaggc cgcgatcgcc gcctcacccg tgtggcagcc cgagcccgag ccggagaagg
     5761 agctgccgcc gcccggcatg tgggtcgagg cgttcatggc cggactgaag ggcgacccgg
     5821 acccggccgc actcacccag aacccggacg acccggacga gtccaccggc atcaccgctc
     5881 tcaccacgaa caacgagtcg gcccgcacgg acaccgacga cgagggggac ctcaagtgat
     5941 ccagcaacga gccaatttcg actggctgct gaaggatctg gccgacggcg tacccggcat
     6001 ccagcagatc gtggtgctct ccgccgacgg tctgcggatc gcccgctacg gcggtgacgc
     6061 cgatgccgcc gaccgggtcg ccgcggcctg cgcgggactg cagagcctgg ccggcgccgt
     6121 ggccagtgag atcccgcaga gcgacggcca catgcggatg gtcatcatcc agatcaacgg
     6181 cggctacttc tatctgatgg ccgccggctc caacgcctat ctcgcggtgc tcgccaacga
     6241 gatcgccgag cccgggctga tgagcaaccg catgcgcgat ctcgtcgacc ggatcggctc
     6301 ccacctcacc agtccgccgc ggcggaacgg gcagaccgta tgacgcctcc gcggcgccag
     6361 cggcgccagc ccaaacacga gccgcccgca ccgccgccgc ccctggacgc ccccacgagc
     6421 ggaacggggg agcgcccccc ggagcggctc tacatcctca ccggcgagga cggcgagcga
     6481 gccccgatcg acctcgtcac gttaatcgtg gcgtgtgccg acgcgccgcc gtccgccgcg
     6541 ccggagcagt cggcgctgct ccggatctgt caggcacccc tgtccgtggc cgagatctcg
     6601 gcctatctca acctgccgat cagcgtggtg accgtcctgc tcaccgagct gctgacggcc
     6661 gaactggtac aggcacgcgc accggtcgtc cggcaggcgc gggcagaccg ttccctcctc
     6721 gaagcggtga tgcatggact tcaaaagctc tgacaccatc acgggtccac ggaccgagga
     6781 ccacctgccg cacactgcgc aggccgcggc gaagatcgtg atcgtgggcg gtttcggggt
     6841 cggcaagacg accatggtgg ggtccgtcag cgagatcagg ccgctgacga ccgaggagac
     6901 catgacgcag gccggcatcg gagtcgacga caacttcggc tccaagacca agacggccac
     6961 caccgtggcc atggacttcg gccgcatcag catcacggac gagctggtgc tctatctgtt
     7021 cggcaccccc ggacaggagc gcttctggtt cctgtggaac ggcctgttcg aaggcgccct
     7081 cggcgcggtc gtcctggtcg acacccgcag gctggaggtc agcttcgacg tcatgggccg
     7141 cctggaggag cggggtgtgc cgttcgtcgt cgcgatcaac gacttcccgg acgctcctcg
     7201 ctacgcgatc gaggaactgc gtcaggcact cgacctgccc gaggagctcc cgatcctccg
     7261 ctgcgacgcg cggcgccggg cctccagccg ggatgtcctg atgaccctca tgcgcttcct
     7321 gcactccctg accatgtcgg gatcggcgtc cgcgtgaacc ctgtgagccc tgtacgagtc
     7381 ccgtgaacat cctcaggccg ggagccgtgt cgtcccgcac ggtgtccctc tcccggcctc
     7441 cccagcaact ccccagacac cggatccacc tcagttcgga gcgatcaccg tgacgcctga
     7501 atcccactcc ctgaccggca cggccgaccc cacgcccggg ccgccccccg gttgccccgc
     7561 ccatggcatg ggtcccggcg ggctgcgccg cctgtacggc cccgaggcgg aggacctggg
     7621 agccgtgtac gagaaactgc gcgcggagca cgggccggtg gcccccgcgc tgctccacga
     7681 ggacgtgccg atctgggtgg tgctcggcca cgccgagaac ctgcacatgg tgagcactcc
     7741 ctcgcagtac tgcaaggaca gccggtcgtg gactcccatg ctggatggca cggtcaagcc
     7801 cgaccacccg ctgatgccgc acttcgcctg gcagcccatc tgcgcgcacg ccgaaggcga
     7861 tgagcatctg cggctgcgcg gtgcggtcac cggcgccatg tcgaccattg accaccgggg
     7921 catccgccgc cacatcaacc gtgcgaccca gcacctcgtc aaccagttct gcgaggacgg
     7981 cagggccgac ctggtcggcc agttcgccga gcatctgccg atggcggtca tgtgcgagat
     8041 cctcggcatg cccgaggagt acggcgaccg gctggtgcag gccgcccgcg actgtctcaa
     8101 gggtagcgag accgcgctcg ccagccacgc ctacctcatg gaagtcctca gccggctcgc
     8161 cgtccgtcgc cgggcccagc ctcaggagga cttcaccagc cacctcgtca cgcacccggc
     8221 cgggctcacc gacgaggagc tcagggaaca cctgcgcgtg gtgctcctcg cctcctacga
     8281 ggccacggcc aacctcctcg ccaacgtgct gcgcatggtg ctcaccgaac cgggcttccg
     8341 ggcccagctg aacggcggcc agatgaccgt gcccgaggcg gtcgagcagt ccctgtggga
     8401 cgagccgccg ttcagcaccg tcttcgccta cttcgccaaa caggagacgg agctgggtgg
     8461 ccagcgcatc cgcaagggcg acggactcct cctcggcatg gcaccgggca acgtcgatcc
     8521 gcgcgtccgc cccgacctca aggcgaacat gcagggcaac cgctcgcacc tcgccttcag
     8581 cggcggccct catgagtgcc cgggccagga catcggccgc gccatcgccg acgtcggcgt
     8641 cgacgcactg ctggcccgcg ttccggacat ccaactggcc tgtgcggagc acgagctgcg
     8701 ctggcggtcg tccgtctcca cccggcacct ggtggaactg ccggtgaagt tcgagccgaa
     8761 gtcaccgcag gagatcatgg agcggcccac cgtcaagccg gtgccgtcgc agcgcgcgaa
     8821 caactggcag gtcggcaggg agcagcccca gcccacggct ccggaacccg cggtcccggc
     8881 cgacgagccc acaccggcgt cggcgcccga accggccgga cggccgggcg tgttccggcg
     8941 tctcctgcgc tggtggcgcg gcaactgagc cgaccgggca ctggggctac cctgcccact
     9001 cctcgtacga gggccaggcc cgcagcaccc gcgggctgac gaaccggtgc tcgcgccccg
     9061 tgaccggatc ggtgaactcc aggacccgcg cgagcagttg gagcgggcgc cggaagtcac
     9121 cggccgccac ggggccggtc accaccggat agagggggtc gccgaggatc ggcaccccca
     9181 acgcgctcat gtgcacccgc agttggtgtg tctgcccggt actcggtgtc aaccggtacc
     9241 gggcccgccc gtttcggtgc tcgagcaact cgacccggct ctcggcgttg ggctcgccct
     9301 cgacctcgta ggccgccggc accccgcgct ccttgacgat ccggctgcgc acggtacggg
     9361 gcaggaccag tgcgggatcg tacggggcca ccgcctcgta ctccttcgcc acccgcctgt
     9421 cgcggaacag cgtctggtac gcgccgcgct ccttcggcct cacggtgaac agcaccaggc
     9481 cggccgtcag ccggtccagg cggtgagccg cgctcagtgt cgggattccc agctgtcgac
     9541 gcagccgcgc cagggccgtc tcggcgacat ggctgccgcg cggggtcgtg gccaggaagt
     9601 gcggcttgtc ggccaccacc acgtgttcgt cccgatacgc gacgtcgacc gtgaacggta
     9661 cgcgctcctc gtccggcagg tcccggtgga accacacgaa catccccggc acgtacgcca
     9721 tgtcccacgg caccgggcgc ccggtggcgt ccacgatgtg tccctcgtcg agcatgttgt
     9781 cgatcaaccc ggccctggcc gggagccgcg ctacgagata atcccgcacg gtcgcccacg
     9841 tgtccccggt cggcaaccgc acccgcaccg gatccacccc gtcgcgctgc ggcaggggag
     9901 agggcggggg tggagtacgg cgtctcatca cgatcaagcg tacgtggcgg taccgacagg
     9961 atgccgatca cgccctggat cttgttggac gagatgatgt ctacgcatct cctggggcag
    10021 gtgcctgata ccgcggggca atcgtcgtcc acacgtccac ggcggcgagg tggtaacgca
    10081 tcgcttcgag gacggccgac agttgctcac gatcgttgcc gttcagctgc agctgttcgc
    10141 agagtgccgg gagtcgagtg ctctcgagat actcgtattc cgactgcctg gccgcacgca
    10201 gtcgggtgac caaggccgcg gcctcgtcga cggagatgtc caagaacctc gcgaatacga
    10261 ggacgaagtt acacgtctcg tcctccttct cgacctctcg gcggtaggag cggacgtcgt
    10321 tgtacagagt ttgaaggtct gtccaggcgt ccatcagcgc acggaacgga cgggactggc
    10381 gcacgcgcgc cggcacttcc gcggctgcta cgtgctcggc aaggcagatc ccgacgtggc
    10441 cgccgaagga gccgcggcgg cggacaaggt actcggcagg atcagggatt cgcccagtgc
    10501 acatgcattc cagctcccag cactgcccgt cggcatattc catcacggcg ttcagcatgt
    10561 tgcgtttcca agccgccgac cgggttggcg tcatccgtag ccatatgtca gcgagggacc
    10621 tctcaatggg gtggtccggt atcgcgcggg aggtgccgtc gagcggcatg aacgcagaga
    10681 gccggtcgac catggcccgc gcccctgtga ggtcgcgctc agctttgaac gtccgtacaa
    10741 acagcaggtc gagggcgaac atccacgcgt acaagtggta tgccaggaac agctcatcct
    10801 cttccgcgaa gggatagcac cacgcagtga tatcggcgag tccgatggcc tcccactcgt
    10861 ccgggtcggc cgcgaggggc aggagcccca tgttgtacgt ccacacgtcg ccgtcgcgat
    10921 tcagcaggtc aacgctcggg ttcccctgcc atgtgtaaag cgctcggagc gagggtgtgc
    10981 tcatcgtgct gatctcctgt cgggtattca agagctggca tgagcggtaa ctctcagtcc
    11041 atggactacg cgctgttccg tacgctgcga ccgcggcgtg gctgactcgt gcatgaaggg
    11101 ggctcgccgg ctgaaccggt cgagcggggc ctcggcgacc ggtgcgccgg ggtggcaccg
    11161 tcgaccacac attccggtgc gcctgcggct ttagtcaact gttcgaggca aactggagct
    11221 tgtggaaggc gccgtcgcgc agcagcgcga agagtgcctc gggcggcacc cggtcccgtg
    11281 ttctgggtga tccactggat ggcccggccg acggtgtgtg catccggaca ccacctccac
    11341 gggcccgggc acgacaccct ttcatgccgt caattcaccc tgaaagaccc ttgctttgga
    11401 ccatgcaatg gtattcggcg cttggaaagg gcgcccggcc ccggcgcatg gagctacccc
    11461 ggcgcatgca gcggccctgc actcgccgga tgcgcggctt cacacgccgt ccagtgtgcc
    11521 gtccgtgcgc tgtccgatct gggacaacaa ggcttattgt ggcggcaatt gggccggatc
    11581 cgcgagagcc cgagcaggtt ccgcggcaga gcgcacgcgt cgcgagcgca tcagccggta
    11641 cagaactccg agcactaccg tgaccagcaa gaacagcacg gtgaaccact ggaagtacca
    11701 atgtccaccc gccgggtcat aaaccgccgc acgcggccag gccaggttga cggtcatgaa
    11761 caggccgtag aggagggcga gggcgttgac ggggacgccc cagcggccga gggagaagag
    11821 gggcttgccg gtctcgtcgg tgccgtccga ggcgaaagtg cccttcaggc gccgtacgag
    11881 gagcgggccg gtgaccatcg cgtaggcgag gtagagcatc acgatgcagg tggtgccgat
    11941 ggccaggaac gcctcgggtg aggcgaagtt gaggagcagg agggcggcgg cgaggaggcc
    12001 gacgaccacg gcgggggcgg tgggcatgcc ggtgcgcgcg ttgaccttgg cgagccgccc
    12061 ggcgaagggg agctggccgt cgcgggccat cgagaagagc atgcggcagg ccgacgtctg
    12121 gatcgcgagc gtggccacgg tgatcgccac caccacgtcc gcgagcagga agcggcccag
    12181 tccgtcgccg aggctgctgg tcaggacgta gctcaggccc tccacaccca gcctgccgtc
    12241 ggtgaggctg ggcgcggcga gcaggccggc gaggacgagg aggccgccga gcagaccggc
    12301 cgcgccgagt gccgtgagga tcgtacgggg cgcggtgcgg cgggggtggt gggtctcctc
    12361 gctcatctcg cccgcgctgt cgaagccgat catcacgtac gccgccatga acgagcccac
    12421 gaggagggcg ccgaggaggt cggtgctgcc ctcggcggtg tggaaggtga tgccggggga
    12481 acgctcggag tgggtgagga gcaggacgac gatcaggatc gcgccgatga tctcggcggt
    12541 gacgccgacc cggttgacca cggacagcac ccggttgtcg aggaggttca cgaccgtggt
    12601 gaggaccagc aggatcacgc ccaggacggc cgcgttcgcc gcacccgtgg ccgaggtggg
    12661 tgtcgggtcg ccgccgacga gctggaagcc cgaccagatc gcgggcatca ccatctgcag
    12721 cgcgagcgcg gccgccgcga ccaccacgat ctgtccgatc accatgatcc agccggcgaa
    12781 ccagccgaac gtctgggtgg acagccgcga ggaccactgg tagatcgcgc ccgatatcgg
    12841 atagcgcgcc gccagctccg cgaagcacgc ggccaccagc agctggccga tcagcaccgc
    12901 cggccaggtc cagaagaaga ccgggccgcc gaacgcgtac ccgaaggcga agaactggaa
    12961 gacggtcgtg aggaccgaga tgaaggagaa accggcggcg aacgaggcgt atctgttcag
    13021 gctgcggtgc agctcctggc ggtagccgaa ctcggtcagg gaacggtcgt cgggggagtg
    13081 gggtggttcc ggtcggacat cgggggcggt gctcgtcatg gcggcaacct gctttcgcaa
    13141 caagcggcgc gagctttcgc gcgagagcgg cgcgaattcc tgtcgggcga cagaaattgg
    13201 ggagtggcga cagaaattag gggagtcctg tgtcgcgtgt gtcacgcgac cgtgtccggg
    13261 gcgggcccaa atcctcacga ctttttcagg gtgggcagtt gggggcaagg gaggggagcg
    13321 aggaggtgtc gtcgagcggc acgccccaca ccgcagaccc ccacagcgag gatccccgga
    13381 tgaacgacgc gtcgccctcc taccggttcc ttccgggcgc gccggagtcc cccgtgctcc
    13441 tgcacgtgcc gcacagctca cgggtgatcc cggcggccgt acgggacggg atcgtcctcg
    13501 acgacgccgc gctggaacgg gagttggacc acatcaccga cgggcacacg gaccggatcg
    13561 ccgagcaggc cgccgaccgg tcggccgtgc gcccctggcg gttcgtcaac cagctgtccc
    13621 gtctcgtgat cgatccggag cggttcccgg acgagcggga ggagatgctg gccgtgggga
    13681 tgggtgccgt ctatacgagg accacgcacg gggaggtgct ccgcgcggcc ggcccggacg
    13741 gcctgccact cggcggacag ccgctcatcg acggttactt ccacccgtac gccgacgcca
    13801 tgaccgacgc cgtgacggat cgcctcgatg ccgtcggccg ggccgtggtc atcgacgtcc
    13861 actcctaccc gaccgggccc ctgccctacg agctccacgg cgacggccct cgcccgcccg
    13921 tctgcctggg cagcgacgcc ttccacaccc cgcccggcct gctgggcgcc gccgaggacg
    13981 cgttcgccgg tttcggcggc accggcgtca acagcccgtt cgggggcgcg tacgtcccgc
    14041 tgacgtacta cgggcacgac cgccgggtga ccgccctgat gatcgagatc cgccgggatg
    14101 tctacatggc ggagccgggc ggggctgcgg ggccggggct gggccgactc gcggacgcgc
    14161 tggcccggtt ggtggacgta ctcacgagcg cctgaacgtc cccaacccgg tctcgtcgaa
    14221 cgcctcgatc gtcacctcgg tggccttgcc gttcgcgtcg cccttgaagg tgacgccgga
    14281 ggggccgctc gcgttctcgc ccaccgtttc gaagaagtac gtgtcgccgg cgtagtgggt
    14341 caggcggaag gtcatgggtt tggggccgag gcgcatggtc aggtcgccgc cggttttcgt
    14401 gacggtgagg gggccgtagt acgcgttggt gtaggtgccc gtgtaggtgg cgtcggcgcg
    14461 ggcgtcggag gcgtcctccg ggggcttgcc gtagtcggtg ggggagcggg acttctgggc
    14521 ctcctgctca tagagccggc cggccaggtc cagccagtcc tcggtcggct tgccgtgctg
    14581 ggccgtgtcg aggaagtcca gggagacggc gtcggcgagg ccgacgggtt cgccgttggt
    14641 gaggacggcg atgccgagct gttcgccggg cagcatcatg acgttggtgt tggcgccgag
    14701 ggcgaaggcc ccggagtggc tgaggcggag gcggcccagg tcgtcgtagg agacgttcca
    14761 gccgaggccg tagaagccgg cgcggcccgc cggggcgggc ggcggctggg agacgatctc
    14821 ggggacgtgg gtgcgttcga gggggtcggc ggcgatgaca cggtcgccgt ccagctcgcc
    14881 gttcgcgagc tggagccgca gccagaggga gaggtcgcgg accgtggagc tcgcaccgcc
    14941 ggccggggac tgggcgtcgg cgtcccggac gtgcctcgcc tcccaggtgc cggtgccggt
    15001 gccggtgccg gtgtcatcgt cgccggtgtc gccgtcgcgg acgtgcgcga aggccttgtc
    15061 ggtcgcggcc tcgtagtcgt tgaagcggga gctggtggcg tccatgccgg ccggcttgta
    15121 gagcgtgtcc tcggcgagct tctcccagct cgtcccggcg gcgtcggcga cggcctcgcc
    15181 cgccgccgtg acgccgaagt tggtgtaggc gtagctcgcg cggaacggcg tcaggggctc
    15241 caggcggagg tgttcgagga cgtagtcgcg gtcgtagccg aggtcctcca ggagatcccc
    15301 ggcgtggtcg gggaggccgc tgcggtggga gaagaggtcc gcgatggtga cgtggtcggt
    15361 cacccagggg tccttcaggg cgaaggacgg gaggtgctcg gacaccgggt cgtcccagtc
    15421 gacggtcttg tcgccgacgg ccccggcgac gacggtcgag gccagtggct tcgacaggga
    15481 ggccagctgg aacaccgtgt cggggccgac ctcggcgtcc tggccgacat gccgcttgcc
    15541 gtagccgtcc aggtggacga cccggtcctg gtacacgacg gccaccgcga cgcccggcac
    15601 cccggtccgg tccatgccgc gctcgacgat gccgtccagg gcgtcgaccg cccggtcgac
    15661 gtcctcctgg gtcagctggg gcggcggctg cggcggggga gccgccgaga cggtgccgat
    15721 gccgtacggg acacagccga ggacgaggag cgaggcgagg gccgtcgcgc cccgggtcct
    15781 gcttcggtgg tgtgtcctcg cgtgccgaac acccatgtgt tcattcaaac gggtgagccg
    15841 ggctttgtcc tgtggaggac ggggcccggc cgccgggggg cacgcgggtg ggaggtggga
    15901 gtcgtccgag gtcacgcggg tgggaggtgg gagtctccgg aggtcacgcg agtgggaggt
    15961 gggagtctcc ggaggtcacg gggtgggagg tgggagtcgt ccgaggtcac ggggtgggag
    16021 gtgggggtcg cccgaggcct caggctcgga tgtcggagtc gtccgatgcc tcggcggtcg
    16081 gatcgccgcc cggccgccga ggctgcgtgg ggcagccgcc acggccgcgc aaggctgtgt
    16141 ggttcagccg ccacagccgc gcaaagctgt gagggtcagc cgccgcagtc gtgcgaggcg
    16201 gcgcttcccc gatcgccccg atcaccccgg tcgtccgacg tcacgccgtc gcggacacgc
    16261 catcctgttc cgcctcgacg cgcgcgttcc actccttctt cgcggcctgc cagccgtcct
    16321 cgtcgtggcc gaggcgccag tagccggaga cggacaagtc ctcgcgcggg acggagagtt
    16381 cgacgcgcag cagtcggcgc agctccttca cgaagcccgc ctcgccgtgg acgaaggcgt
    16441 gcagccggcc ctcggggaac tccagcgcgc gtacggcctc gacgagggcg gcgccgatgg
    16501 gacggtcgcc gcggtgcagc cagacgacgt ccacatcgga gttgatcttc tgctcctcct
    16561 cgggaccggc gacctcgacg agcgcgtgga cccgggcgcc gtcgggaagg gcctccaggg
    16621 aggcgccgat cgcgggcagg gcgctctcgt cgccgacgag cagatgccag tcggcctccg
    16681 ggttgggcgc gtaggcaccg cccgggccca ggaaacggac cagctcgccc ggctggacgc
    16741 gggtcgccca gggaccggcg agaccctcgt cgccgtggag cacgaagtcg atggtcagct
    16801 cgcgcagtcc gggatcccag gcccgcacgg tgtacgtccg ggtcaccggc cactggtccc
    16861 gggggaactc cgcacggatc cgctccaggt cgaagggctc cggatacgtc atgccctcgg
    16921 ggccgaacag gagcttcaca taatggtcgg tgctgccgcg cggggagaac tccgcgaggc
    16981 cgtcgccccc cagcacgacg cgctgcatgt gcggggtgag ccgctctgtg cggacgactc
    17041 gcccggagtg gggcttcggg gtcctgcgta ccggacgctc tgccatgacg gcctcccaag
    17101 tacctactaa ggcttaccta agttagcatc tccccctgtt gtacacctca tgcttgagag
    17161 gtgtacgcgg acttcatggt gtgaatcgcg cctcaaagcc ctcaccaccg aagtgtctcc
    17221 ccaccctccg gcgtgcgccc cgcccggggg ggcgtccacc tcacgcctgc agcgtcgtga
    17281 gcaaccgctg cagcgatccc ccgaggcccc agcgcgccgc gagctcctcc agcgccgccg
    17341 gatctcgcgg cgcgcgcggc agcgccgtgt cgacctccgg caacggtacg tcggccgcca
    17401 cctggacgac cgtgggtgcg accgcgacat aaggtcgcgc ctcgtcgagt ctcttgcgct
    17461 gtgacggcgt cagcttggcc gccgggtcgt cgaccgcggc catgatcccg gccaggtcgc
    17521 cgaactggtc gaggagtttc gcggccgtct tctcgccgat gccgggcaca cccggcagac
    17581 cgtcgctcgg gtcgccgcgc agcagggcca gatccgcgta cccgcggccg tccacgccat
    17641 acttctcgcg cagccatgcc tcgtcggtca gctgcagcga gcccacgccc ttcagcgggt
    17701 acagcacacg cacgccgcgc ccgtcgtcga ccagctggta caggtcgcgg tcgccggtga
    17761 cgatgtcgac cgggtccttc gctcgggccg tgaaggtgcc gatcacatcg tccgcctcgt
    17821 acccggcgac gcccacgcgc gcgatgccga gcgcgtccag cacctcctcg atgaccggca
    17881 cctgcggcga cagcgtgtcc ggcacctcct cctcgtccgg gccgacctcg tgctcctcgg
    17941 cgacgcggtg cgccttgtag gaggggatca ggtcgacccg ccactgcggg cgccagtccg
    18001 cgtccatgca tgccaccagg tccgtcggcc ggtggtcccg gaccaggcgg tcgatgaatt
    18061 cgagcagccc gcgcacggcg ttcaccgggg tgccgtccgg ggccttcacg gagtccggta
    18121 ccccgaagta ggcgcggaag tacagggagg cggtgtcgag gagcatcagg cgtcgggtca
    18181 cgccccgcat catgccgcac ggcaccgaca cgcggctccc gacccaaccg cgcgtggcat
    18241 gcgtgcacgc gttccgtgaa gaccccgtcc cgtgttccgt gaatacctct ggcctgcggt
    18301 gaatgcactg tgaagcgggc cactgtcgcg tttgccgtgg tgggggcagg gcaggcgcgg
    18361 ccccggagca gcgccggtcg tgtgctgaga ccaccgaccg ggcgggccga tcccgccgcg
    18421 ctccacggcc ggcctgcggg cgggggaggc gggccgttcc tgtcgctatc caagaggtgc
    18481 atgtgtcagc cagggagtca tccagactcg aagccgaagg cctgtacaag gtcttcggca
    18541 gacgacccga cgacgcggtg gaccggctcc gggccggcgc cgaccgcgag gaactgcgcg
    18601 ccgagggcac caccgccgcc gtgatcgacg cctccttcac ggtggagccg ggccagatct
    18661 tcgtcgtcat gggcctgtcc gggtccggca agtccacgct gctgcgcatg ctcaacgggc
    18721 tcctggagcc caccgccggg cacgtccgct tcgacggccg ggacctgacc gcgctgagcg
    18781 accgcgagct gcgcgcggtc cgtgccggga gcatcagcat ggtcttccag cacttcgcgc
    18841 tgttcccgca ccgcagcgtc ctggagaacg ccgcgtacgg cctggaggtc cagggcgtgc
    18901 cgcgtgccga acgcgtgagg cgtgccaccg aggcgctggg cctgtgcggt ctggccggct
    18961 gggagacgtc ctggcccgac gaactgtccg gcggtatgca gcagcgtgtg ggcctggccc
    19021 gcgccctcgc caccgacgcc gatctgctgc tgatggacga gtcgttcagc gcgctcgacc
    19081 cgctgatccg ccgtgacatg caggaccagc tgctggagct gcagcagacc ctgaagaaga
    19141 ccatcgtctt catcacgcac gacctcaacg aggccatgcg cctgggcgac cgcatcgccg
    19201 tcatgcgcga cggccgcatc gtccagaccg gcaccgccga ggacatcctg atccgccccg
    19261 ccgacgacta cgtggcctcc ttcacccagg acgtcgaccg ctcccgggtg ctcaccgccg
    19321 gtgccgtcat ggacacggcc gtacgcggcg acgaggcgga ctgcggctgt gagaccgcga
    19381 cgccgggcac gccgttcacg gaactctgcg cgatcagcgc ccgcctgtcc catccggtcg
    19441 cggtgctcga caagcagggc gccctcgtcg gcgtcgtacc gcgccaccgc ctgatcggct
    19501 tcctcggcga ccagcaggtc gagcccacgc cgtgcgacgc cccgcgcgac aaggccgtac
    19561 gggcggtgaa ggccagtgcc taggatccac atcggcgact gggtctccca cggcgtcgac
    19621 tggctgcgcg acaacctcgg ctggctcttc gacctcatca agatcgtcgt cgagtccctg
    19681 tacgacgggg cgaacgcggt gctcaccgcg cccgacccgc tgctcctcgc cggcatcctc
    19741 gccctgctcg ccttctggct gcgcggcctg ctgcccggtg tcctggcctt cgccggcctg
    19801 gcgctgatcg actcgatcga gcagtgggaa ccggcgatga actcgctctc gctggtgctc
    19861 gtctcctgcg tgatcatctt cgccttcgcg gtgccgatcg gcatctgggc ggcccgcagt
    19921 cgcgcggtca gcggagcggt gcggccggtg ctcgacctca tgcagaccat gccggcgatg
    19981 gtctatctga tcccgggcat cttcttcttc ggcgtaggcc cggtgcccgg catggtcgcc
    20041 accatcgtct tcgcgatgcc gcccgccgta cgcctcaccg agctcggcat ccggcaggtc
    20101 gacgccgaac tggtcgaggc cgccgaggcg ttcggcaccc acccgcgccg cacgctgtgg
    20161 cgggtgcagc tgccgctggc gctgcccacg atcatggcgg gcgtcaacca ggtgatcatg
    20221 ctggccctct cgatggtcgt catcgcgggc atggtcggcg gtggcggcct cggctccacc
    20281 gtgtacgacg gcatcagctc cgtcgacgtc ggcctcggct tcgagggcgg tgtcgcggtg
    20341 gtcatcctcg cgatctacct cgaccgtatg accagcgccc tcaaccagcg cgtgtccccg
    20401 ctcggccgcc gcgccctcgc caaggcgaac acggcactcg gcggcctgag gttcctccgc
    20461 tggaagccgg ccacgccggt cgcgatggtc ggtgtgctcg tcctcgcact ggtcgccggc
    20521 ggcctgaacg tcttcggcag gacggacgac ggcaccgagg tcggcgcgaa cgtcggccag
    20581 ggccgcccgg tcagcatggg ctacatcgac tggcccgagg gcgtggcctc cacgtacctc
    20641 tggaaggaga tcctccacca gcgcggcttc acccccgagg tgaagtcgct ggaggtcggc
    20701 gccctctaca acggtcaggc gcagggcagc gtcgacatcc agaccaactc ctggctcccg
    20761 gccacgcacg cctcgtactg ggcgaagtac aaggaccggc tggaggacta cggcagctgg
    20821 tacgacaaga cctcgctgga gatcgccgtc ccgtcctacg tcaagggcgt ggactcgctc
    20881 gacgacctca agggcaaggg cgatctgttc aaggggaaga tctacggcat cgagccgggc
    20941 gcgggcgaga ccaagctcta cgaggacaag gtccgacacg ccta
//
