LOCUS       NZ_CP102512            13450 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces sp. CA-210063 chromosome, complete genome.
ACCESSION   NZ_CP102512
VERSION     NZ_CP102512.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CA-210063
  ORGANISM  Streptomyces sp. CA-210063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10859970)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Jorgensen,T.S., Klitgaard,A.K.,
            Mourched,A.S., Blin,K., Oves-Costales,D., Genilloud,O., Larsen,T.O.,
            Tanner,D., Weber,T., Gotfredsen,C.H. and Charusanti,P.
  TITLE     Identification of the Biosynthetic Gene Cluster for Pyracrimycin A,
            an Antibiotic Produced by Streptomyces sp
  JOURNAL   ACS Chem Biol 17 (9), 2411-2417 (2022)
   PUBMED   36040247
REFERENCE   2  (bases 1 to 10859970)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Assembly Name                     :: M642_aaa1.6.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 55.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 11:12:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,501
            CDSs (total)                      :: 9,410
            Genes (coding)                    :: 9,051
            CDSs (with protein)               :: 9,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 141 of 359
            Pseudo Genes (incomplete)         :: 302 of 359
            Pseudo Genes (internal stop)      :: 23 of 359
            Pseudo Genes (multiple problems)  :: 101 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7473018
            Orig. end                         :: 7486468
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102512.1.
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..13450
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aminopolycarboxylic-acid"
                     /region_number="24"
                     /rules="(AesA and AesB and AesC)"
                     /tool="antismash"
     cand_cluster    1..13450
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(AesA and AesB and AesC)"
                     /kind="single"
                     /product="aminopolycarboxylic-acid"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..13450
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8450](+)"
                     /cutoff="10000"
                     /detection_rule="(AesA and AesB and AesC)"
                     /neighbourhood="5000"
                     /product="aminopolycarboxylic-acid"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8450
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(AesA and AesB and AesC)"
                     /neighbourhood="5000"
                     /product="aminopolycarboxylic-acid"
                     /protocluster_number="1"
     gene            complement(387..1202)
                     /locus_tag="JIX56_RS32660"
                     /old_locus_tag="JIX56_32660"
     CDS             complement(387..1202)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006138032.1"
                     /locus_tag="JIX56_RS32660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32660"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_257545892.1"
                     /transl_table=11
                     /translation="MTPRLRATAVRVLPPLLLVCLALVGPWIAPHPIDAPVTAPYAEPG
                     PDALLGGDQLGRDVLSRLLAGGRDLVLSSTLVAVLVTGSAAVLGAIGALRPRVGRLVER
                     TADVVMLLPAVLGILLVTLSWPDGGRLAVIAAAVVLGVPYAVRLAAGAAGPVAASGYVE
                     AAAAGGERLWHLVLREVLPNLRATLLALFGLRFVAAVYLVATAAFLQVGPQPPAADWAL
                     MIRENSSGILLNPWAVVAPSAAIGLLALSVNLAAAALAPQTGRKAVTVL"
     gene            complement(1199..2119)
                     /locus_tag="JIX56_RS32665"
                     /old_locus_tag="JIX56_32665"
     CDS             complement(1199..2119)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998460.1"
                     /locus_tag="JIX56_RS32665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32665"
                     /product="ABC transporter permease"
                     /protein_id="WP_257545894.1"
                     /transl_table=11
                     /translation="MGAVVLKRAALLVVLLALVFLTVELLPGDAAAATSERGESAADIE
                     RRRELLGLNRPVLERFWDWMSGLPTADLGTSARGEKVTDLLSSAFPNTLVLGGLALLLT
                     AALSLGLGCWAALRPDGRVDRAVSGTATAVLALPEFVVAVALLLVLSLWTGWLPAVTLT
                     DADGTPSDWTMLILPALALTIPQTGWNTRIVRAALADEARAPHVETAVLDGLPPHRVLT
                     HHVLPGALPTVTAGLATSTGMLLGGAVVVETIFNYPGIGSVLASAVTDRDSPVIAGVTA
                     LAGAVITGVLLLADLVRDLTTGSRR"
     gene            complement(2206..3759)
                     /locus_tag="JIX56_RS32670"
                     /old_locus_tag="JIX56_32670"
     CDS             complement(2206..3759)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006138034.1"
                     /locus_tag="JIX56_RS32670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32670"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_257545896.1"
                     /transl_table=11
                     /translation="MELTRRHMLWLGGAIGAGTLLTACGGGDEEPAASATGGTAKPVKG
                     GTLRVGALGRAGAITRDPHGSQANESDYLILSLIYDTLTVPGAKPNTAPRLAASWKASD
                     DLKTWRFTIAKGAKFHDGSPVTAEDLVFSLKRLRATPAGASRLPGIQEKNITAEGTDTV
                     VLVSDYANAELPLLTRLTTFVIPKGTTDKDIAKAPGTGPFKLDWFRGGNARLVRNEDWY
                     GGDVHLDAIEVKIFESPQAMASALLAGQIDLASNVGAVAARTAESRKDIQAVRRPNDMA
                     MPIVMRTADGPFADAKVREALRLAVDREAMVKQVLSGYGTVANDILGTGDPAFDKSIPQ
                     RTRDLAKAKELLKEAKFDTSKTYELYTTEDISGLAESATLFATQVREAGVKVKVVKQES
                     GTFWDKTWLKGDLYTTYWGTNDSVVFFASKTMVSDSGQNEAGWKDEAFDEAYEKAIGTA
                     DASARTQLLKQLQQIEYDSSGYLLWGMADGIDLAGAKVNGLPTLPGYGRVQLEQAWLAR
                     "
     misc_feature    3761..3775
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.57"
                     /tool="antismash"
     misc_feature    3789..3807
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.97"
                     /tool="antismash"
     misc_feature    complement(3843..3858)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.91"
                     /tool="antismash"
     misc_feature    complement(3860..3878)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 26.13"
                     /tool="antismash"
     gene            4015..5004
                     /locus_tag="JIX56_RS32675"
                     /old_locus_tag="JIX56_32675"
     CDS             4015..5004
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998462.1"
                     /locus_tag="JIX56_RS32675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32675"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_257545898.1"
                     /transl_table=11
                     /translation="MPTGIAPVRLLDPDSVAELTAAARTLLTSYDGSSTHPGLLAQVPA
                     VAAALSDRIRHACRPVDTAEGLFVLRGLPVDDAALGPTPGHWSTVGDAGAVYDVVLLLL
                     STVMGTPIAWEGQQEGRFVHNIVPSPGHEEEQTGASSSVLLSPHTEDAFHPGRAHLLVL
                     GCMRNPDSVATTAASIRQVELDAGEVKLLSRPVLPILPDDAYEEAQGYAGEPPAVPTLW
                     ESEDGLTLRFDPAYTPLDQAPEDHRAAYARLEDELARVSGAVSLNPGEVLVVDNDLVVH
                     GRVPFKARYDGTDRWLKRSSVRVKGRRTRPPAEESEHGYGQAAVEAFA"
     gene            5001..6023
                     /locus_tag="JIX56_RS32680"
                     /old_locus_tag="JIX56_32680"
     CDS             5001..6023
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998463.1"
                     /locus_tag="JIX56_RS32680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32680"
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="WP_257545900.1"
                     /sec_met_domain="AesA (E-value: 9.7e-178, bitscore: 588.7,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRIDSPGGNAVTPDDKTLRVLSTSDVAGIDITLPDVVSVVEQAY
                     RTLAEGRSDNPQKLTVKPEDGHSVAYAMLGRDGERGVVAVKTSYKYGLHEDRDKQHYYT
                     TLSLYDDATGLPVAMMDCGRVGALRTPAVSALLARELAAPGSRSALVIGTGVQGRLALP
                     FLLTTLPDLDRLMLFGTHPDGIRAVREQLHAHFPERDVEIVTDLRAAAEEADIVLATAG
                     PNTPASVEAEWLKPSALSVLIGYGIAASTLHTADRVIATSEAQMRVTGTDMADASGRLR
                     DVDAEFPEVLAGRAEGRTDAGQRIFAYNSGLVVTDIALGHRFAQLALAQGLGTAVPLWT
                     "
     gene            6020..7381
                     /locus_tag="JIX56_RS32685"
                     /old_locus_tag="JIX56_32685"
     CDS             6020..7381
                     /EC_number="5.1.1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998464.1"
                     /locus_tag="JIX56_RS32685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32685"
                     /product="alanine racemase"
                     /protein_id="WP_257545902.1"
                     /sec_met_domain="AesB (E-value: 1.6e-224, bitscore: 744.1,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 5.6e-27, bitscore:
                     93.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTLTSHTTEEVRALLAPPGSALPHELSHGLGGPYHLLFPQRFD
                     ANAAAFRQAFADAGVDGRVYFAKKANKAAVFVERAAVAGLGVDVASHGELREALAAGVR
                     GTDLVVTGPAKDDQLLRVAVLHGALVAVDALDELDRVLALADELGRTARVLLRRLPPGQ
                     PHSRFGLDDAEMNTALRRCRTEHVDMAGFSFHLSGYDIRERADLAAELVRLCAQARTWG
                     LRADRISVGGGFAVDYVGAEDWRRFQESTRPEHFHKHKAFSGYYPYHSPVAGADALAAM
                     LTTTPAGEESTLAELVRAAGVTLLVEPGRALLDQAGCTVFRVQGVKERDGYDILTVDGS
                     SLSLSEQWFESEFLPDPVLIPADRADIADAGPYPACVGAATCLESDMLTWRKIPFPVRP
                     ATGDLLVYLNTAGYQMDSNESPFHELPLPPKVVIEPPTYDSPSARPRWRLDRHP"
     gene            7404..8450
                     /locus_tag="JIX56_RS32690"
                     /old_locus_tag="JIX56_32690"
     CDS             7404..8450
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006138038.1"
                     /locus_tag="JIX56_RS32690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32690"
                     /product="cysteine synthase family protein"
                     /protein_id="WP_257551265.1"
                     /sec_met_domain="AesC (E-value: 9.4e-191, bitscore: 632.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PALP (E-value: 3.1e-54, bitscore: 183.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHPLHRPAIVRQVSELIGATPLFELCRTESDARLLLKLEQFNPT
                     GTAKIRMARQMVIDAEERGLLRPGGRIIESTSGNTGLGLAVVAAERGYTFTAVVDHHAS
                     KDKLRAMKAMGTELVYVADEGDDDLATAAREELAERMAAESDNAYFTEQHNNLANGVGY
                     HPVARELDAALDGRIDILIGAVGTGGGLFGTGGALRRTVPEVTIVGVEPKGSIAFGPPA
                     HDYHQSGTGTPEGATIGAMVDYGLLDEGAKVGDVEAFATARAVARRTGLLLGGSAGGVV
                     YEALTRMTSLAPGTTMVALINDGGEKYLDTVFDDDWMSARDLLSPDVEREVDELLAKLR
                     RVAPDARG"
     gene            8491..9891
                     /locus_tag="JIX56_RS32695"
                     /old_locus_tag="JIX56_32695"
     CDS             8491..9891
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998466.1"
                     /locus_tag="JIX56_RS32695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32695"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_257545904.1"
                     /transl_table=11
                     /translation="MPPALARLLGDSRALASLAVPLALTQLAQVALTTTDTVMMGLLGT
                     EALAAGGLAMVIFNQLRTMGVGMVTAVGNQVAAADARAESAGVSEEAQEDVRDLVRASL
                     LLSTLAGVVGAVLMVLIGHAVILLGQDPEVVDAAKPVLYTMAPGLIPCLWFQAIRQFTV
                     GMRRPQALLRITLASIAVNVGLNWAFIHGTWIFPELGLPGIGLSTSLVYALSCLALYFS
                     ARRDARLAPVLSLSIWKTRPATLRRLTGLGTPIAATYGSEAGFFFVVALFAGSFGTSAL
                     AAHTAVNQLVYIVFQIAVGLSHAASIGVSRELALHHLAAAQRLKTTALACAAAVMAVVG
                     LVYVTLPGLVLAPFFDSGDDRAVEIATQLLLVAAVLQFFDCTQNIGVGLLRGLDDTKGG
                     FRVTLVGYWLVGLPAAVLLGLATGLDTLGIWLGLLTGLATTAVLLLRRFNRGLDRLPRA
                     TEPAPSQA"
     gene            complement(9947..10393)
                     /locus_tag="JIX56_RS32700"
                     /old_locus_tag="JIX56_32700"
     CDS             complement(9947..10393)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003967.1"
                     /locus_tag="JIX56_RS32700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32700"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_257545905.1"
                     /transl_table=11
                     /translation="MAMEKTTVPTPRVDSLTLEVVELIGTVVARYHEEYEDAAAEHSLT
                     GAQARLLGLLSLEPLPMRRLAQKLRCEPSNVTGIVDRLEGRGLVERRPDPNDRRVKLAA
                     ATQEGRRVARSLRDSLGFAREPLAGLSAAERESLRNLLRRMLDA"
     misc_feature    10409..10425
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.49"
                     /tool="antismash"
     misc_feature    complement(10411..10424)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.33"
                     /tool="antismash"
     misc_feature    10434..10447
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            10506..11528
                     /locus_tag="JIX56_RS32705"
                     /old_locus_tag="JIX56_32705"
     CDS             10506..11528
                     /NRPS_PKS="Domain: PKS_ER (73-338). E-value: 1.1e-23.
                     Score: 75.8. Matches aSDomain:
                     nrpspksdomains_JIX56_RS32705_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048551.1"
                     /locus_tag="JIX56_RS32705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32705"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_257545907.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.2e-21, bitscore:
                     74.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTPALPATSREWHLLSRPVGWPKDEDFALVEAEIRQPGTGEVL
                     VRNKYLSVDPYMRGRMSDAKSYVAPFELGKVMQGGAVGEVVASGAEGIAVGDHVLHFGG
                     WREYATFDAKQAVKVDPDAAPLSAYLGVLGMTGLTAYAGLLRVGAFKEGDAVFVSGAAG
                     AVGSQVGQIAKLKGASRVIGSAGSDEKVKLLVEEYGFDAAFNYKNGPVWEQLKEAAPDG
                     IDVYFDNVGGEHLEAAIGALNLRGRAVICGMISQYNATEPTPGPRNMVKILQNRLRVEG
                     VLVGDHYDLQPQFVQDIGPWVASGELKYRETVVEGIENNLEAFLGVLRGDNTGKMIVKL
                     "
     aSDomain        10725..11519
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIX56_RS32705_PKS_ER.1"
                     /evalue="1.10E-23"
                     /label="JIX56_RS32705_PKS_ER.1"
                     /locus_tag="JIX56_RS32705"
                     /protein_end="338"
                     /protein_start="73"
                     /score="75.8"
                     /tool="antismash"
                     /translation="GKVMQGGAVGEVVASGAEGIAVGDHVLHFGGWREYATFDAKQAVK
                     VDPDAAPLSAYLGVLGMTGLTAYAGLLRVGAFKEGDAVFVSGAAGAVGSQVGQIAKLKG
                     ASRVIGSAGSDEKVKLLVEEYGFDAAFNYKNGPVWEQLKEAAPDGIDVYFDNVGGEHLE
                     AAIGALNLRGRAVICGMISQYNATEPTPGPRNMVKILQNRLRVEGVLVGDHYDLQPQFV
                     QDIGPWVASGELKYRETVVEGIENNLEAFLGVLRGDNTGKMIV"
     gene            complement(11643..12821)
                     /locus_tag="JIX56_RS32710"
                     /old_locus_tag="JIX56_32710"
     CDS             complement(11643..12821)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004001553.1"
                     /locus_tag="JIX56_RS32710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_32710"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_257545909.1"
                     /transl_table=11
                     /translation="MTQQTGTVTVHGTVADGFEAVREEFAAFVATERADYEGQLTAYVH
                     GRRVVDLWAAPEADAAAGGDSLHGVFSSTKGAAHLVVALLVQDGVLKLDREVAHYWPEF
                     AAEGKGSVTLRELITHRAGLIGIDAGFTDEELADDRVIAERLAVQRPFWRPGSAFGYHA
                     LVIGALTGEVVRRATGRTLPEVYEERVRAPYGLDFFLGLPPGHEPRFRTVLPMVPTPAQ
                     QAELDAVPRGPHTLSSIAFNSQVPDPGELTDFPNSPAVRASGQASAGGIASARGLAGMY
                     AAAISTVDGRPPLLKPDTIAEVGQIHSLGFDLVARAPRAYGLGFQATGENLYPFLGAGA
                     FGHSGAGGSQAFADPRSGLAYGYTRRRMAFPGGAAPENAQLVRAVHTAASAG"
     misc_feature    12919..12933
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.13"
                     /tool="antismash"
     misc_feature    13425..13440
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.79"
                     /tool="antismash"
ORIGIN
        1 gagttcgcgc aggagggagc ggacgcgcat ccgggggttc agtcccgagc cggggtcctg
       61 accgacgtag gcgagccgct cgcggcgcag ggcacgcagc tcccgttcgg acagggcgaa
      121 cacgtcacgg ccgaggactt ccacacgtcc ggacgtgcgc tccgtgccgg gcggcaggag
      181 tccggtgagg gcgcgcagca gcgtggtctt gcccgaaccg gagggaccgg tcagcgcggt
      241 caccctgccc gggtgcaggg tgagtcgggc gtcctggagc aggatccgcc cgtcgggggc
      301 ggccacggtg aggtccgtga cccgggccgc cggggtggcg gcgggcgtgg gggagtcgtc
      361 cttccggtac cggtcgggtg tgtgactcac aggacggtca ccgccttccg gccggtctgc
      421 ggggcgaggg ctgccgccgc gaggttgacg ctcagggcga gcaggccgat ggcggcgctg
      481 ggggcgacca cggcccaggg gttgagcagg atgccggagg agttctcgcg gatcatcaac
      541 gcccagtcgg cggccggggg ttggggcccg acctggagga acgcggccgt ggcgaccagg
      601 tagacggcgg cgacgaagcg cagaccgaac agggcgagga gggtggcccg caggttcggc
      661 agcacctcgc gcagcaccag gtgccacagc cgttcgccgc cggccgccgc ggcctcgacg
      721 taaccggacg cggcgacggg gcccgccgcg ccggccgcga ggcgcaccgc gtacggcacg
      781 ccgaggacga cggcggcggc gatcacggcg agtcggccgc cgtccggcca ggagagggtg
      841 acgaggagga tgccgagcac ggcgggcagc agcatcacca cgtcggcggt ccgttccacc
      901 aggcgtccga cgcggggccg gagcgcgccg atcgcgccga gcaccgccgc actgccggtg
      961 acgagcaccg cgacgagagt ggaggacagg accaggtcgc ggcccccggc cagcagccgg
     1021 ctgagcacgt cccggccgag ctggtcgccg ccgagcaggg cgtccgggcc gggttccgca
     1081 tagggcgcgg tgaccggggc gtcgatggga tgcggcgcga tccagggccc gacgagggcc
     1141 agacacacga gcagcagcgg gggcaggacg cgtacggcgg tggcgcgcag gcggggggtc
     1201 atcggcggct tcccgtcgtc aggtcccgta ccaggtcggc caggagcagt acgccggtga
     1261 tgaccgcgcc ggcgagggcc gtcaccccgg cgatgacggg gctgtcgcgg tcggtgaccg
     1321 ccgaggccag gaccgagccg ataccggggt agttgaagat ggtctccacg acgacggcgc
     1381 cgccgaggag catgcccgtg gaggtcgcga ggccggcggt gacggtgggc agggcaccgg
     1441 gcaggacgtg gtgggtgagg acccggtgcg gcgggagccc gtcgaggacg gcggtctcca
     1501 cgtgcggggc gcgggcctcg tcggcgaggg cggcgcgcac gatgcgggtg ttccagccgg
     1561 tctgcgggat ggtcagggcg agcgcgggca ggatcagcat ggtccagtcg gagggggttc
     1621 cgtcggcgtc ggtgagggtg acggcgggca gccagccggt ccacagcgac agcaccagga
     1681 gcagggcgac ggccaccacg aactcgggca gcgcgaggac cgcggtcgcc gtgccggaca
     1741 ccgcccggtc cacccgcccg tccggtcgga gcgcggccca gcagccgagc cccagggaca
     1801 gcgcggcggt gagcagcagc gcgagcccgc cgaggacgag ggtgttgggg aaggcactcg
     1861 acagcaggtc ggtcaccttc tcgccgcgcg ccgaggtgcc caggtccgcg gtgggcaggc
     1921 cgctcatcca gtcccagaag cgttccagga ccggtctgtt caggcccagc agctcccgcc
     1981 gccgttcgat gtcggccgcg ctctcgccgc gctcggaggt cgcggccgcg gcgtccccgg
     2041 ggagcagttc gacggtgagg aacaccagcg cgaggagcac cacgagcagc gccgcccgct
     2101 tcaggacgac agcacccacc cgggcgagca gcagcagggg agcccgcgcc ggccggaccc
     2161 tcggagtcag gggagagggt ccggccggcg cggtcgtgtc aggcgtcaac gggccagcca
     2221 cgcctgttcg agctggaccc tgccgtagcc gggcagcgtg ggcagcccgt tgaccttggc
     2281 cccggcgagg tcgatgccgt cggccatgcc ccacagcaga tagccggagc tgtcgtactc
     2341 gatctgctgg agttgcttca gcaactgggt gcgcgcgctc gcgtcggcgg tgccgatggc
     2401 cttctcgtag gcctcgtcga aggcctcgtc cttccagccg gcctcgttct ggccgctgtc
     2461 ggagaccatc gtcttgctgg cgaagaagac gacggagtcg ttggtgcccc agtaggtggt
     2521 gtagaggtcg cccttgagcc aggtcttgtc ccagaaggtc cccgactcct gcttgacgac
     2581 cttgaccttc acgccggcct cgcggacctg ggtggcgaag agggtggccg attcggcgag
     2641 accggagatg tcctcggtgg tgtacagctc gtacgtcttg gaggtgtcga acttcgcctc
     2701 cttcagcagt tccttggcct tggcgaggtc acgggtgcgc tgcgggatgc tcttgtcgaa
     2761 ggccgggtcg ccggtgccga ggatgtcgtt ggcgacggtg ccgtagccgg agaggacctg
     2821 cttgaccatg gcctcgcggt cgacggccag gcgcaacgcc tcacggacct tcgcgtcggc
     2881 gaacgggccg tcggcggtgc gcatgacgat gggcatggcc atgtcgttgg ggcggcggac
     2941 ggcctggatg tccttgcggc tctcggccgt acgcgcggcg acggcgccga cgttggaggc
     3001 gaggtcgatc tggccggcga gcagggcgct cgccatggcc tgcgggctct cgaagatctt
     3061 gacctcgatg gcgtcgaggt gcacgtcgcc gccgtaccag tcctcgttgc ggacgaggcg
     3121 ggcgttgccg ccacggaacc agtcgagctt gaaggggccg gtgccggggg ccttggcgat
     3181 gtccttgtcg gtggtgccct tcggtatgac gaaggtggtg aggcgggtca gcaggggcag
     3241 ttcggcgttg gcgtagtcgg agacgaggac gacggtgtcg gtgccctcgg cggtgatgtt
     3301 cttctcctgg atgccgggca gccgggaggc gcccgcgggg gtggcgcgca ggcgcttcag
     3361 cgagaagacg aggtcctcgg cggtgaccgg tgaaccgtcg tggaacttcg cgcccttggc
     3421 gatcgtgaac cgccaggtct tcagatcgtc cgaggccttc cagctcgcgg cgaggcgggg
     3481 cgccgtgttg ggcttggcgc cggggacggt cagggtgtcg tagatcaggc tgagaatgag
     3541 gtagtcgctc tcgttggcct gactcccgtg cggatcacgg gtgatggcgc cggcgcggcc
     3601 gagcgcgccg acccgcaggg tgccgccctt gacgggcttg gccgtaccgc ccgtggcgga
     3661 cgcggccggc tcctcgtcgc cgcctccgca ggcagtgagc agggtgccgg ctccgatggc
     3721 gccaccgagc cagagcatgt gacgtcgcgt cagctccact tgttcctcat tttcccgcag
     3781 ttggctggat tgcttagcct tacctaccct gtgtcgcccc tgtacgacaa gaccaccaac
     3841 ggtgtgacat agatcaaagt taggtaagcc ttccctgttt acctgtgggg tggctatgtt
     3901 tccaacgggc tacccgagat cgcatccgac cacgcgatcg ggatcgggag gccttcttcg
     3961 ccatgcccgg agatcctcaa caccttgccc cgcaccggaa cgaacggatc ccccatgccc
     4021 acgggaatcg cccccgtacg tctgctcgat cccgactcgg tggccgaact gaccgccgcc
     4081 gcccgcaccc ttctcacctc gtacgacggc tcatccaccc acccgggcct gctggctcag
     4141 gtccccgccg tcgccgctgc gttgagcgac cggatacgcc acgcctgccg ccccgtcgac
     4201 accgccgagg gcctgttcgt gctgcgcggt ctgcccgtcg acgacgcggc gctcggtccc
     4261 actcccggcc actggtcgac cgtcggcgac gccggtgccg tatacgacgt cgtcctgctc
     4321 ctgctgtcga cggtgatggg tacccccatc gcctgggagg gacagcagga aggccgtttc
     4381 gtgcacaaca tcgtgccgtc tcccggccac gaggaggagc agaccggcgc cagcagcagc
     4441 gtgctgctca gcccgcacac cgaggacgcc ttccaccccg gccgggccca cctcctggtc
     4501 ctcggctgca tgcgcaaccc cgactcggtc gccaccacgg cggccagcat ccgccaggtc
     4561 gaactcgacg ccggtgaagt gaagttgctc agccgcccgg tcctgccgat cctccccgac
     4621 gacgcctacg aggaggccca gggctacgcg ggcgagccac cggccgtgcc cacgctgtgg
     4681 gagtcggagg acggcctgac cctgcgcttc gacccggcct acaccccgct ggaccaggca
     4741 cccgaggacc accgcgcggc ctacgcccgc ctggaggacg aactcgcccg cgtcagcggc
     4801 gcggtgagcc tgaaccccgg tgaggtcctg gtcgtcgaca acgatctggt cgtccacggc
     4861 cgggtgccct tcaaggcccg ctacgacggc acggaccgct ggctgaaacg ttcctccgtg
     4921 cgcgtgaagg gccgccggac ccggccgccc gccgaggagt ccgagcacgg ttacggccag
     4981 gccgccgtgg aggcgttcgc atgacccgca tcgacagccc cggagggaac gccgtgacgc
     5041 ccgacgacaa gaccctgcgc gtcctcagca ccagcgacgt ggccggcatc gacatcacgc
     5101 tgcccgacgt cgtctccgtg gtggaacagg cctaccgcac cctggccgag ggccgctccg
     5161 acaatccgca gaagctcacc gtcaagcccg aggacggcca ctccgtggcc tacgcgatgc
     5221 tcggccggga cggggagcgc ggggtcgtcg cggtcaagac gtcgtacaag tacggcctcc
     5281 acgaggaccg cgacaagcag cactactaca cgacgctgag cctctacgac gacgccacgg
     5341 gcctgccggt cgcgatgatg gactgcggcc gcgtcggggc actgcgcacc ccggccgtct
     5401 ccgcgctcct cgcccgcgaa ctcgccgccc ccggcagccg cagcgccctc gtcatcggca
     5461 ccggcgtcca gggccggctc gctcttccct tcctgctgac cacgctgccg gacctggacc
     5521 ggctgatgct cttcgggacc caccccgacg gcatccgggc cgtacgcgaa cagctgcacg
     5581 cccacttccc cgagcgggac gtggagatcg tgacggatct gcgcgcggcc gccgaggagg
     5641 cggacatcgt gctcgccacc gccggcccca acacgcccgc gtccgtcgag gccgagtggc
     5701 tgaagccgtc ggccctgtcc gtgctgatcg ggtacggcat cgcggcctcc accctgcaca
     5761 cggccgaccg cgtcatcgcc accagcgagg cccagatgcg ggtcaccggt accgacatgg
     5821 cggacgcgag cggtcgactg cgcgacgtgg acgccgagtt ccccgaggtc ctggcgggcc
     5881 gtgccgaggg ccgtacggac gccggacagc ggatcttcgc gtacaacagt gggctggtcg
     5941 tcaccgacat cgcgctcggc caccggttcg cacagctcgc gctcgcccag gggctgggca
     6001 cggcggtacc gctgtggacg tgaccaccac cctcacctcg cacaccaccg aggaggtgcg
     6061 cgcgctcctc gccccgcccg gcagcgccct tccgcacgag ctgagccacg gtctgggcgg
     6121 gccgtaccac ctgctgttcc cgcagcggtt cgacgccaac gccgccgctt tccggcaggc
     6181 gttcgccgat gcgggcgtgg acggccgggt gtacttcgcc aagaaggcca acaaggccgc
     6241 cgtcttcgtg gagcgggcgg ccgtcgcggg cctgggcgtg gacgtggcga gccacggcga
     6301 gctgcgcgag gcgctggcgg ccggtgtgcg cggtacggac ctggtcgtca ccggcccggc
     6361 caaggacgac caactgctgc gggtcgccgt gctgcacggc gcgctcgtcg ccgtggacgc
     6421 cctcgacgaa ctggaccgcg tcctcgccct cgccgacgaa ctcggccgta ccgcccgggt
     6481 gttgctacgt cgccttcccc ccggccagcc gcacagccgc ttcgggctgg acgacgccga
     6541 gatgaacacg gccctgcgcc gctgccgcac cgagcacgtg gacatggcgg ggttcagctt
     6601 ccacctctcc ggctacgaca tccgtgaacg ggccgacctc gccgccgagt tggtacggct
     6661 gtgcgcccaa gcccgtacgt gggggctgcg ggccgaccgg atcagcgtcg gcggcggctt
     6721 cgcggtggac tacgtgggcg cggaggactg gcgccgcttc caggaaagca cccgccccga
     6781 gcacttccac aagcacaagg ccttctccgg ctactacccg taccactcgc ccgtcgccgg
     6841 agccgacgcc ctcgccgcca tgctcacgac cacgccggcg ggcgaggagt cgaccctggc
     6901 cgaactggta cgggcggccg gggtgacgct gctcgtcgag ccgggcaggg cgctgctgga
     6961 ccaggcgggc tgcaccgtct tccgggtcca gggcgtcaag gaacgcgacg gctacgacat
     7021 cctcaccgtg gacggcagca gcctcagcct gtccgagcag tggttcgaga gcgagttcct
     7081 cccggacccg gtgctcatcc ccgccgaccg ggccgacatc gccgacgcgg gcccgtaccc
     7141 ggcctgtgtg ggcgccgcga cgtgcctgga gtcggacatg ctcacctggc gaaagatccc
     7201 cttccccgtc cgcccggcca ccggcgacct gctggtgtat ctgaacaccg cgggctacca
     7261 gatggactcc aacgagtccc cgttccacga gctgccgctg ccgcccaagg tcgtcatcga
     7321 gccacccacg tacgactccc cctccgcccg tccccgctgg cgtctcgacc gccacccgta
     7381 gggagttctc agccatgaac cctctggacc accctctgca ccggccggcc atcgtccgcc
     7441 aggtctccga actcatcggc gccaccccgc tgttcgagct gtgccgcacc gagagcgacg
     7501 cacggctgct gctgaagctg gagcagttca acccgaccgg gacggcgaag atacgcatgg
     7561 cccggcagat ggtgatcgac gccgaggagc gcgggctgct gcgccccggc ggccggatca
     7621 tcgagtccac ctcgggcaac accgggctcg gtctcgcggt cgtcgccgcc gagcgcggct
     7681 acacgttcac cgcggtcgtc gaccaccacg cctccaagga caagctgcgc gccatgaagg
     7741 ccatgggcac ggaactcgtc tacgtcgccg acgagggtga cgacgacctg gccacggccg
     7801 cgcgtgagga gctggcggag cgcatggccg ccgagtccga caacgcctac ttcaccgagc
     7861 agcacaacaa cctcgccaac ggggtcggtt accacccggt ggcccgggag ctcgacgccg
     7921 cgctggacgg ccgtatcgac atcctgatcg gcgcggtcgg caccggcggc ggcctgttcg
     7981 gcaccggggg cgcactgcgc cggaccgtgc ccgaggtcac gatcgtcggg gtcgagccca
     8041 agggctccat cgccttcggg ccgcccgcgc acgactacca ccagtcgggg accggcacac
     8101 ccgagggcgc caccatcggc gccatggtcg actacgggct gctggacgag ggcgcgaagg
     8161 tcggcgacgt ggaggccttc gcgaccgcgc gggccgtcgc ccgccgcacc gggctgctgc
     8221 tcggcggctc ggcgggcggg gtggtgtacg aggcactgac ccggatgacc tcgctcgcgc
     8281 cggggacgac tatggtcgct ctgatcaacg acggcgggga gaagtacctg gacaccgtct
     8341 tcgacgacga ctggatgagc gcccgggacc tgctctcccc cgacgtcgaa cgcgaggtgg
     8401 acgagctgct cgccaaactc cgccgcgtcg caccggacgc gcggggataa caccccgtcg
     8461 tacgcccccc acaccccagg aacggaaccg atgccgcccg ccctcgcccg cctcctcggc
     8521 gacagccgcg ccctcgcctc gctcgccgtg ccgctggcgc tcacccagct cgcccaggtc
     8581 gccctgacca ccaccgacac cgtcatgatg ggcctgctcg gcaccgaggc cctggcggcg
     8641 ggcggcctcg ccatggtgat cttcaaccag ttgcgcacga tgggcgtcgg catggtcacc
     8701 gccgtcggca accaggtcgc ggcggccgac gcgcgggcgg aatccgccgg ggtctccgag
     8761 gaggcgcagg aggatgtccg ggacctcgtc cgcgccagcc tcctgctgtc caccctcgcg
     8821 ggcgtcgtcg gtgccgtcct gatggtgctc atcgggcacg ccgtgatcct gctcggccag
     8881 gacccggagg tggtcgacgc cgcgaagccc gtcctctaca cgatggcgcc cggactgatc
     8941 ccctgcctgt ggttccaggc gatacggcag ttcaccgtcg gcatgcgccg cccccaggcc
     9001 ctgctgcgca tcaccctcgc ctcgatcgcc gtcaacgtgg gcctcaactg ggccttcatc
     9061 cacggcacct ggatcttccc cgagctgggc ctgccgggca tcggcctgtc caccagcctg
     9121 gtgtacgccc tgtcctgcct ggccctctac ttctccgccc ggcgcgacgc ccggctcgcc
     9181 ccggtgctgt ccctcagtat ctggaagacc cggcccgcca cgctgcgcag gctcaccggc
     9241 ctcggcacgc cgatcgccgc cacctacggc tccgaggcgg gcttcttctt cgtcgtcgcg
     9301 ctcttcgcgg gcagcttcgg cacgtcggcg ctggccgcgc acaccgccgt caaccagctc
     9361 gtctacatcg tcttccagat agccgtcggc ctctcccacg ccgcgtccat cggggtcagc
     9421 cgtgagctgg cgctgcacca cctggccgct gcccagcgcc tgaagaccac ggccctggcc
     9481 tgtgcggcgg cggtgatggc cgtggtcggg ctggtgtacg tgaccctgcc gggcctggtc
     9541 ctcgccccct tcttcgacag cggcgacgac agggccgtgg agatcgccac gcagctgctg
     9601 ctggtcgccg ccgtactgca gttcttcgac tgcacccaga acatcggcgt cggtctcctg
     9661 cgcggcctcg acgacaccaa gggcggcttc cgggtcaccc tcgtcggcta ctggctcgtg
     9721 ggcctgcccg ccgcagtcct tctcggcctc gccaccgggc tggacaccct cggcatctgg
     9781 ctcggcctcc tcaccggcct cgccaccacc gccgtactcc tcctgcgccg cttcaaccga
     9841 ggcctcgacc ggctgccccg ggcgacggaa ccggcgccgt cccaggcctg atgctccgct
     9901 cggttcggcc ggcggaccac ccgccggccg tccgccgccc tacgtcttac gcgtccagca
     9961 tccgccgcag cagattccgc aacgactccc gctcggccgc gctcaacccg gccagcggct
    10021 cccgggcgaa gcccagggaa tcccgcaggc tgcgagccac ccgccgcccc tcctgcgtcg
    10081 ccgcggccag cttcacccgt cggtcgttgg ggtcgggtcg ccgctcgacc agcccccgcc
    10141 cctccagccg gtccacgatc cccgtcacgt tcgacggttc gcagcggagt ttctgggcga
    10201 ggcggcgcat ggggagcggt tccagggaca gaagaccgag gaggcgggct tgggccccgg
    10261 tgagggagtg ttccgcggcg gcgtcctcgt actcctcgtg gtagcgggcc acgaccgtac
    10321 cgatgagctc gacgacctca agggtcagcg agtcgacgcg gggggtcggg acggtcgtct
    10381 tctccatggc catgggctcc agactacctc tttacttgac aacatgaaat attcaagcgc
    10441 atggttgttt caggtagtga agtaaccgca cggtatgtac gaacgcaccc gcaggaaggc
    10501 cccccatgtc cgacaccccc gccctccccg ccaccagccg cgaatggcac ctgctgagcc
    10561 gccccgtcgg ctggcccaag gacgaggact tcgccctggt cgaggcggag atccggcagc
    10621 ccggcacggg tgaggtcctc gtacggaaca agtacctctc cgtggacccg tacatgcgtg
    10681 gccgcatgag cgacgcgaag tcgtacgtcg ccccgttcga gctgggcaag gtcatgcagg
    10741 gtggtgccgt gggcgaggtc gtggcctccg gggccgaggg catagccgtc ggtgaccacg
    10801 tgctgcactt cggcggctgg cgcgagtacg cgaccttcga cgccaagcag gccgtgaagg
    10861 tggacccgga cgcggcgccg ctctccgcct acctcggcgt cctcggcatg accggtctca
    10921 ccgcctacgc gggcctgctg cgggtcggcg ccttcaagga gggcgacgcg gtgttcgtgt
    10981 ccggcgccgc cggcgccgtc ggcagccagg tcggccagat cgccaagctg aagggcgcct
    11041 cccgtgtcat cggctccgcc ggctccgacg agaaggtcaa gctgctcgtc gaggagtacg
    11101 gcttcgacgc cgccttcaac tacaagaacg gcccggtctg ggagcagctc aaggaggccg
    11161 ccccggacgg catcgacgtc tacttcgaca acgtcggcgg cgagcacctg gaggccgcga
    11221 tcggcgcgct caacctgcgc ggccgggccg tgatctgcgg catgatctcc cagtacaacg
    11281 cgaccgagcc gacccccggc ccgcgcaaca tggtcaagat cctgcagaac cgcctccgcg
    11341 tcgagggcgt cctcgtcggc gaccactacg acctccagcc ccagttcgtc caggacatcg
    11401 gcccctgggt cgcctcgggc gaactcaagt accgcgagac ggtcgtcgag ggcatcgaga
    11461 acaacctcga agccttcctc ggcgtcctgc gcggcgacaa caccggcaag atgatcgtca
    11521 agctctgaag aagctcgcgc ggcagaaccc gtgacgcttg tatgactcag tcgttgcaca
    11581 cgccggagtc cgcacccctg gacgtggggt gcggactccg ccatgtgtgc ggacgtacgg
    11641 cctcagccgg ccgacgccgc cgtgtgcacc gcccgcacca gctgcgcgtt ctccggcgcc
    11701 gccccacccg ggaaggccat ccggcggcgg gtgtagccgt atgccaggcc gctgcggggg
    11761 tcggcgaagg cctgggagcc gcccgcgccg ctgtggccga aggcgccggc gcccaggaag
    11821 gggtagaggt tctcgccggt ggcctggaag ccgaggccat acgccctggg ggcgcgggcc
    11881 acgaggtcga agccgaggga gtggatctgg cccacctcgg cgatggtgtc gggcttcagt
    11941 agcggaggtc ggccgtccac cgtgctgatg gccgccgcgt acatgccggc gaggccgcgt
    12001 gcggaggcga tgccgcccgc cgaggcctgg ccgctcgccc ggacggcggg ggagttgggg
    12061 aagtcggtca gctcgcccgg gtccggcacc tggctgttga acgcgatcga ggacagcgtg
    12121 tgcggtccgc gtggcaccgc gtccagttcg gcctgctggg cgggtgtcgg gaccatcggc
    12181 aggacggtac ggaaacgggg ctcgtgcccg ggcggcagcc ccaggaagaa gtcgaggccg
    12241 tacggggcac ggacccgctc ctcgtacacc tccgggagcg tgcggcccgt cgcgcgccgt
    12301 acgacctctc cggtgagcgc cccgatgacg agcgcgtggt agccgaaggc gctgcccggg
    12361 cgccagaagg ggcgctggac ggcgaggcgt tcggcgatga cgcgatcgtc cgccagctcc
    12421 tcgtccgtga acccggcgtc gatgccgatg agccccgccc ggtgcgtgat cagttcccgc
    12481 agggtcaccg aacccttgcc ctcggccgcg aactccggcc agtagtgggc gacttcacgg
    12541 tccagcttca gcacaccgtc ctggacgagg agcgcgacga cgagatgggc ggcccccttg
    12601 gtggaggaga acacgccgtg cagcgagtca ccgcccgccg ccgcgtccgc ctcgggggcc
    12661 gcccacaggt cgacgacccg ccgcccgtgc acatacgcgg tcaactgccc ctcgtaatcg
    12721 gcccgttcgg tggccacgaa cgcggcgaac tcctcgcgca ccgcctcgaa gccgtcggcg
    12781 accgtgccgt ggacggtgac cgtccctgtc tgctgtgtca tcgcgctccc gcctgaatga
    12841 tcgaccgatg atgagtgggt caggacaccg tcagcaacgc ccgccccacc tgcgggaatt
    12901 ctcccttcgg gtggtcacgg aagagcggtt ccgtgccgaa gaggacagcg ttcgggccgc
    12961 tgacgacgga cggccggccc gccgccgctg ccgggccgcc ggcgccgtcc tcccgtggcc
    13021 gccagtgccc ggagacgagc gggtttccgg tgccgtacga ctgctcgacg gtgacgccgg
    13081 ggccgaggtc ggtgaaccag acgggcgcgt agacgaagct gtggtccggt gcgccacctg
    13141 tcaccgggcc gcccgaattc accacgcgga ccacgccgtt ggcgtccccg ttgcccgcca
    13201 ccgctgtcgc cttcagctgc ccggtggccg tggtgagcgc ggcgccggtc gcgccccggc
    13261 cgaccagccc gtggccgccg aggaagtcgg cgagggccgt acgggcggac gcgttcagac
    13321 cgccgtacga cagcccggac gacacgaaga gcacatcggc cctcgaccag tcgaagcccg
    13381 cgttgaggac cgccgtcgac accgggacga cgtcgaagtt catctcgcgg agtgcgaaca
    13441 gctcgcccgc
//
