LOCUS       NZ_CP102512            20882 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces sp. CA-210063 chromosome, complete genome.
ACCESSION   NZ_CP102512
VERSION     NZ_CP102512.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CA-210063
  ORGANISM  Streptomyces sp. CA-210063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10859970)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Jorgensen,T.S., Klitgaard,A.K.,
            Mourched,A.S., Blin,K., Oves-Costales,D., Genilloud,O., Larsen,T.O.,
            Tanner,D., Weber,T., Gotfredsen,C.H. and Charusanti,P.
  TITLE     Identification of the Biosynthetic Gene Cluster for Pyracrimycin A,
            an Antibiotic Produced by Streptomyces sp
  JOURNAL   ACS Chem Biol 17 (9), 2411-2417 (2022)
   PUBMED   36040247
REFERENCE   2  (bases 1 to 10859970)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Assembly Name                     :: M642_aaa1.6.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 55.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 11:12:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,501
            CDSs (total)                      :: 9,410
            Genes (coding)                    :: 9,051
            CDSs (with protein)               :: 9,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 141 of 359
            Pseudo Genes (incomplete)         :: 302 of 359
            Pseudo Genes (internal stop)      :: 23 of 359
            Pseudo Genes (multiple problems)  :: 101 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6647793
            Orig. end                         :: 6668675
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102512.1.
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20882
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="bottromycin"
                     /region_number="21"
                     /rules="botH"
                     /tool="antismash"
     cand_cluster    1..20882
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="botH"
                     /kind="single"
                     /product="bottromycin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20882
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10882](-)"
                     /cutoff="20000"
                     /detection_rule="botH"
                     /neighbourhood="10000"
                     /product="bottromycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10882)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="botH"
                     /neighbourhood="10000"
                     /product="bottromycin"
                     /protocluster_number="1"
     gene            complement(15..491)
                     /locus_tag="JIX56_RS29100"
                     /old_locus_tag="JIX56_29100"
     CDS             complement(15..491)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980613.1"
                     /locus_tag="JIX56_RS29100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29100"
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_257544939.1"
                     /transl_table=11
                     /translation="MDTSWWLALAAVVLLALLATVVDGWGRSRRPSRRSERPGGRTRPP
                     GRPGRARGPVPRPRPSEIWWASVPFEDGPGGKDRPCLVLAVRGDRARVAKITSRYRDER
                     AGVIPLPPGTVGDARGRPSFLETGELREVPVGDFRRKAGVVDPVLWDQIRRLSN"
     misc_feature    763..775
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.78"
                     /tool="antismash"
     gene            849..1601
                     /locus_tag="JIX56_RS29105"
                     /old_locus_tag="JIX56_29105"
     CDS             849..1601
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009336460.1"
                     /locus_tag="JIX56_RS29105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29105"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_257544940.1"
                     /transl_table=11
                     /translation="MKLTVVGCSGSFPSAESACSSYLVEADGFRLLLDMGNGALGELQR
                     HCGLYDLDAIFLSHLHADHCIDMCAYFVARYYRHDGGRCDPIPVYGPEGTEQRLTTAYA
                     DTPSASSMSEVFDFHTVKPSTFELGPFTIHTERVAHPVEAYGIRIEHGGRVLTYSGDTG
                     VTHTLDELARDSDLFLCEAAFTHGKENIPDLHLNGREAGETAARAGARRLVLTHIPPWT
                     DPQVNLVDAREVYDGPVELAVPRMSYEI"
     gene            complement(1686..2939)
                     /locus_tag="JIX56_RS29110"
                     /old_locus_tag="JIX56_29110"
     CDS             complement(1686..2939)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388569.1"
                     /locus_tag="JIX56_RS29110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29110"
                     /product="PTS transporter subunit EIIC"
                     /protein_id="WP_257544941.1"
                     /transl_table=11
                     /translation="MSTATAPSAAPAKKWGSGLMQGLQKVGRSLQLPIAVLPAAGLLVR
                     LGQPDVFGAEGLGWDKVAAVFDKAGGAITGNLAMLFCIGVAIGFAKKADGSTALAALVG
                     FLVYSKVLEAFPVTEAEITKGADVAATYNNPGVLGGIVMGLLSAVLWQRYHRKKLPDWL
                     GFFNGRRLVPIIMAFVGVAVGVFFGLVWEPIGEVIGSFGEWMTGLGSAGAALFGAINRA
                     LIPIGMHQFVNTVAWFQLGEFKDASGVVSHGDLSRFLAGDPTAGMFMSGFFPIMMFGLP
                     AAALAIAHTARPERRKVVTGMMISLALTSFVTGVTEPIEFSFMFIAPLLYVIHALLTAL
                     SMAITWGLGVHAGFNFSAGFIDYALNWNLATKPWLIIPIGLVFGAIYYVVFRFAIVRFN
                     LPTPGREPDEEIEDLTKA"
     misc_feature    complement(2958..2973)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.49"
                     /tool="antismash"
     misc_feature    complement(2975..2990)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.9"
                     /tool="antismash"
     gene            complement(3070..4584)
                     /locus_tag="JIX56_RS29115"
                     /old_locus_tag="JIX56_29115"
     CDS             complement(3070..4584)
                     /EC_number="3.4.11.1"
                     /GO_function="GO:0030145 - manganese ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000048: Hydrolysis (97% identity)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486722.1"
                     /locus_tag="JIX56_RS29115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29115"
                     /product="leucyl aminopeptidase"
                     /protein_id="WP_257544942.1"
                     /transl_table=11
                     /translation="MTRVVAGDVGTDTPDTADTADTADTADTADTASRAADVVAYGRHT
                     GAAVGAFSRRRGFVARPGQVVAEPSADGRAVVLNVGLGPAGSATAATFRAAAAASVRAA
                     GPARTLRLDLALADGSGVPAADRARAVTEGAVLGLYRYDEYRSARAASPLAEVIVATPE
                     RRAVAEGLAAAEATCLARDLVNCPAGTLTPPAFADRIRELAHTAGLDCAVYEGAGLTEL
                     GLTGLTAVGRGSAEPPRYVELTYDPPDADPALTVGLVGKGVTFDSGGLSLKPSGERHAM
                     KADMGGAAAVVAALTALPRLGLPLRVRGHLPLAENMPDGGALRVGDVVRHLDGTTTEIT
                     HTDNEGRVVLADVLVRASRPGPHRSDLVVDVATLTSAAVHALGTRTGALFTPDDQLAQT
                     VLAASERAGESFCRLPLLAHERRNLRSAVADRVNCSHRHGDTIQAALFLQDFVAAGVPW
                     AHLDIAAPAYNDEGPYAEVPYGGTGFAVRTLIETLRALSEGSPDVP"
     gene            complement(4589..5143)
                     /locus_tag="JIX56_RS29120"
                     /old_locus_tag="JIX56_29120"
     CDS             complement(4589..5143)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003256.1"
                     /locus_tag="JIX56_RS29120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29120"
                     /product="DUF2087 domain-containing protein"
                     /protein_id="WP_257544943.1"
                     /transl_table=11
                     /translation="MTTAPTEDQTRAEDLPPSCRDLIGILAQTDRRDAFAALALGATSV
                     AQVAERAGLRPAAAAVALQKLVDGRIAAYDADARTYRLIDDTFRLAVQAEVRISGRGGG
                     DGAGAYFRKGRLTSIPGKAEVRSRVLTVVADSFEAGVTYSEAKVNAICGQWFDDWVTLR
                     RALVDENLLRRDESGTQYERV"
     gene            complement(5308..7362)
                     /locus_tag="JIX56_RS29125"
                     /old_locus_tag="JIX56_29125"
     CDS             complement(5308..7362)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bottromycin_Methyltransferase_RRE"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000047: Methylation (98% identity)"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003257.1"
                     /locus_tag="JIX56_RS29125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29125"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_257544944.1"
                     /sec_met_domain="TIGR03975 (E-value: 3.3e-158, bitscore:
                     526.8, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 1.9e-35, bitscore: 119.9, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTTERTEAIGTAGTTEATGTTEPTLATTPTEPTTPSVPTRPGR
                     VALVSMPWNNVRRPSIQVGTLRSVARAEGWRVDSHYAYLSFYGLARAALGMRDAEWSQA
                     YETVSEGLYQLSVGDWIFACRDGGAAPREAYFRMLRTKGVDDATIELVDALREVADRHV
                     ERTAAELLESAPDLIGFTSTFSQNGPTLAVAERLRDLGYGGVIVLGGSNCEGSMGRALL
                     ANYPAVDAIVDGPGEDAFVTLLRQVGAGDPPRSHGRLITRLPALADSAPAGMSAGQSLE
                     VPTPDYDGFFEQLHTAGLHTLEPEITLPVEFSRGCWWGAKTHCTFCGLNGATMTYRSKN
                     PDTVADELRHLMDRYGVLDFFAVDNILDLKYLDTALPLVEKLNTDHSLFFEVKANMEWA
                     DIQAARRAGVRSVQPGIESLSTEGLRLLKKGATAFQNIRFLLGCAEFGVLPVWNILTGF
                     PHETPESMLTQIDLLPSLTHLEPPDNDILAVHFDRFSPYVEHPQDYGLTLTHPLPGYQY
                     AYPRLSPGDLWDLAYHFEGDFTEDPRNTAVRERLATAVHHWRTEHHRARFTYRLGFDSV
                     TLTDHRPGLPAHTTVLRDEDARLFRAIIGGTRFRDLQNQEGRDGQPLEKLHTWQEKRWV
                     YIEGTKVIALPVREKPSAYRTPPRKGTPRRSRTAVPLTLTGPPPPRRPG"
     aSDomain        complement(5443..5661)
                     /aSDomain="Bottromycin_Methyltransferase_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing methyltransferase protein in a
                     bottromycin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JIX56_RS29125_Bottromycin_Methyltrans
                     ferase_RRE.1"
                     /evalue="5.70E-38"
                     /identifier="RREFam008.1"
                     /label="JIX56_RS29125"
                     /locus_tag="JIX56_RS29125"
                     /protein_end="640"
                     /protein_start="567"
                     /score="119.9"
                     /tool="antismash"
                     /translation="TYRLGFDSVTLTDHRPGLPAHTTVLRDEDARLFRAIIGGTRFRDL
                     QNQEGRDGQPLEKLHTWQEKRWVYIEGT"
     gene            complement(7370..8596)
                     /locus_tag="JIX56_RS29130"
                     /old_locus_tag="JIX56_29130"
     CDS             complement(7370..8596)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000044: Decarboxylation, Oxidation (99% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115557.1"
                     /locus_tag="JIX56_RS29130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29130"
                     /product="cytochrome P450"
                     /protein_id="WP_257544945.1"
                     /sec_met_domain="p450 (E-value: 7.7e-09, bitscore: 33.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQADREPDRTGQEAKRPAEPDHPPQQATCPVDFDFFAAPQTYRDA
                     AAEHAGEHGAFYSDRGFWVLTTYDGIVDAFKDEGTFTVGRVSAAEGAEEERWIPLTVEG
                     REHTAWRQRLGAWFTPQRVRELTPSMRAGARRRIEGFLEKGEVSFNEDFARPYVLENLM
                     TAVGWPPDGFDLLIAINRAMIDSRSAPDPRAAAYGELGLPALERFAREHIARRRAEPAD
                     DLTTASFGWEIDGAEVTDDDRASLLCTLFLAGIDSTVNHLANAVQHLAHHEEDRRRFLA
                     GPEVRPPAVEEFLRANSCMYPGRQAATGGAGGVADRGDTVLLPLALANHDPEVFPEPGR
                     IDFDRARNPHIAFGTGPHQCLGAAFARAQILVALEEWHALVPDYAPSPEQRTAEPPFLR
                     NSYDLRLVW"
     gene            complement(8586..10004)
                     /locus_tag="JIX56_RS29135"
                     /old_locus_tag="JIX56_29135"
     CDS             complement(8586..10004)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000050: Hydrolysis (99% identity)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009298712.1"
                     /locus_tag="JIX56_RS29135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29135"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_257544946.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.9e-06, bitscore:
                     26.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATEDTMWRRRRGLLPDGDPLVRALEELAERGRGHRLRAVGLVD
                     PATGRPGPPHDLTVTDGTVTAWTPTPPASDGRAAPYTSYAVPGLVDSHAHVSSAADLVG
                     LLVHGVTGFRQLWGEPAHLYAAGVHRARHAVLPRPWVTAGVVDGPGSRIPQGVTVVDGV
                     RSVRQVIEDALAFGFDGIKVYDDVARPAFEVLVREAERAGLPVVGHIPEAVPLDLAQRT
                     LRSSEHLYGIVPNVFRLPPERRWDALAAALRDHPAPGAVPGHFVCPTLVCWRARSGERR
                     YTRPSRAALQAVDEGRRRSWQSAARDALRLDAAEVHRRGGLVDELGRIARALADTGTRL
                     LAGTDCGNPFVLAGPSFHKELAELSRAGLDFGAVLRAATTHAYEAMGRRAGPVPGDPAD
                     LVLYRRPPDGDVTALARPDAVLVDGVLLDGTDLDRLWALRLAASGLDPSGWARGTLDPP
                     VTTGRPTKETAHAG"
     gene            complement(10001..10882)
                     /locus_tag="JIX56_RS29140"
                     /old_locus_tag="JIX56_29140"
     CDS             complement(10001..10882)
                     /NRPS_PKS="Domain: Abhydrolase_1 (33-140). E-value:
                     6.1e-14. Score: 44.2. Matches aSDomain:
                     nrpspksdomains_JIX56_RS29140_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     bottromycin: botH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000051: Epimerization (99% identity)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115556.1"
                     /locus_tag="JIX56_RS29140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29140"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_257544947.1"
                     /sec_met_domain="botH (E-value: 4.4e-157, bitscore: 520.0,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2e-10, bitscore: 39.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.9e-08, bitscore:
                     33.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDGNGTSRRDVFEVFSRDGTPIRGFSRPGPGETVVLVHGVAMDR
                     RIWAESGFLDALPDAHVLALDLRGRGESGRVGTAEGHALRRYVEDVRAVLDRFGRARYS
                     LFGTFFGGRIALQVAAVDTRVARAFSFCAHAEQVEIPEDAVEEEAVAVEGPGGHAYLRD
                     HFTGRGAPPWMVEACARVDPGELGAATRGLLHGSDRRTERGHPDQELVLITADGDADLA
                     PFHAGERRLGAHLWLVDAPTRIKAAGRLAEVGRRVAGVLAEGGHGTGDAPGEARTTGDA
                     PAEARASGTGVV"
     aSDomain        complement(10463..10783)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIX56_RS29140_Abhydrolase_1.1"
                     /evalue="6.10E-14"
                     /label="JIX56_RS29140_Abhydrolase_1.1"
                     /locus_tag="JIX56_RS29140"
                     /protein_end="140"
                     /protein_start="33"
                     /score="44.2"
                     /tool="antismash"
                     /translation="TVVLVHGVAMDRRIWAESGFLDALPDAHVLALDLRGRGESGRVGT
                     AEGHALRRYVEDVRAVLDRFGRARYSLFGTFFGGRIALQVAAVDTRVARAFSFCAHAEQ
                     VEI"
     gene            complement(10869..12851)
                     /locus_tag="JIX56_RS29145"
                     /old_locus_tag="JIX56_29145"
     CDS             complement(10869..12851)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bottromycin_Methyltransferase_RRE"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000046: Methylation (99% identity)"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486708.1"
                     /locus_tag="JIX56_RS29145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29145"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_257544948.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.3e-128, bitscore:
                     429.1, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 7.4e-35, bitscore: 118.0, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLALVAPPWNSLYRPSIQIATLAALEGTGDGDPITPVYAYLDWF
                     EYAVDALECDPAEFVTVYDTIGEELYGLGVGDWIFGGVLDAHGPGEEADVRDRYAAFLT
                     EHGVAEELVGRVLALRAVAPGFTAGLAGRLVATGAECFGFTTSFSQLMPALAVARAVKD
                     QAPERLVLLGGANCDRPMGQAVMRAYPFVDAVVQGEGEAAVAAVRAARGAHDLAAAPGL
                     VLRHEGGLRVSLPTVQPAESAPVPRYAEYFERLRALPHRELIAPHVALPFQMSRGCWWG
                     EKLQCTFCGENGSGMVYRSKPGEQLTKTLRRLTEEHGVFDTYAVDTILARNDNGLAELA
                     AAEVDITTFFEVKANLGPREVGEMRAAGVTMVQPGIESLSSGALKLLRKGATAFHNLRF
                     LVLCQELGIDAQWNLLSAMPDETAAMLQEQLRLIPFITHLAPPSTVSKVRVDRYSPYFE
                     KPEEFGIALDGPEPKYRFVHAGRTAAERAELAYSFDHVELAGRDDSAMAAEMLALRRRL
                     GARVGLWKKLHDQSRFSFRFGPNMTVLHDGRPHVGTGRHVLRGGDDQLFRCLVHGGRLH
                     QAVGQVAAMTGRPEDEVHATVREWARRGWIHLEGRRGLVLAVRDGMRDELGRAAELREA
                     AAESERAAAESGMAGAGSGRVGAGR"
     aSDomain        complement(11019..11252)
                     /aSDomain="Bottromycin_Methyltransferase_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing methyltransferase protein in a
                     bottromycin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JIX56_RS29145_Bottromycin_Methyltrans
                     ferase_RRE.1"
                     /evalue="2.20E-37"
                     /identifier="RREFam008.1"
                     /label="JIX56_RS29145"
                     /locus_tag="JIX56_RS29145"
                     /protein_end="611"
                     /protein_start="533"
                     /score="118.0"
                     /tool="antismash"
                     /translation="SFRFGPNMTVLHDGRPHVGTGRHVLRGGDDQLFRCLVHGGRLHQA
                     VGQVAAMTGRPEDEVHATVREWARRGWIHLEGR"
     gene            complement(12848..14203)
                     /locus_tag="JIX56_RS29150"
                     /old_locus_tag="JIX56_29150"
     CDS             complement(12848..14203)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) YcaO"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000053: Cyclization (99% identity)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003262.1"
                     /locus_tag="JIX56_RS29150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29150"
                     /product="YcaO-like family protein"
                     /protein_id="WP_257551184.1"
                     /sec_met_domain="YcaO (E-value: 6.8e-37, bitscore: 127.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTAALLDGAAKDDVPPERETAIQQALSSVGDWLAAERLTADIRK
                     YGIESAPTYEVRLTDARGALCSRSSGKGLGHRSMASALFESAEHYHLDWRRDPRASEAE
                     FLPGREIAGQDTARRSALLRRLGGIMPDAPVLTRTYRPVEETLTGRADHGPAGRPHRHP
                     VFLRDGGYRNWPHPDDDRSFQPLWHYTSSAGYAAGATVHEALVHAVNELIERDAWSYQL
                     ARSYFGLPGEGPELRVVDHDTLPAELRELTGTVEQVREAPVLIVDITCDTGVPAYVVCD
                     ARSREEVRLIGSGASPVRTYALQRALLEYLQVRTMFEHGPVDADTEAGQIATALARYPR
                     HLAAARFDVGQLPHERRAFDADDGLPAAASPEQLLRHLVDRLRDLGVDVHHRVLTPPGS
                     VTVVDVVAPGLEMFDKARAGYPVLPTGRLGERLRPRKNHGEDHGKDHGGAPR"
     gene            complement(14151..15410)
                     /locus_tag="JIX56_RS29155"
                     /old_locus_tag="JIX56_29155"
     CDS             complement(14151..15410)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) YcaO"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000052: Heterocyclization (94% identity)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486705.1"
                     /locus_tag="JIX56_RS29155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29155"
                     /product="YcaO-like family protein"
                     /protein_id="WP_257544949.1"
                     /sec_met_domain="YcaO (E-value: 6.5e-09, bitscore: 35.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEATATECELREVVHRSYPSDRTVTVRCTVRPAEGTAQADGYGT
                     ATTEAVARAKALSEAVERLVACTPFATVARPPTTPAPGSGSGPVPPFPAAGVRTAPDGC
                     ASREYRPLSGDGPRRVPLYWSSPWVAGEELRAGTLSAAEARLSSTVGWAVAPTPEAALR
                     GALLELTELIDYGVFLHRRLAGPARPRSAGDETLVVPLGGAVRTPTVLAVAYGRGRLMP
                     ATGLGCGASRAEATDRALLELAQAETMWRSNPTAEPAERFFLRRFERWPLLTRCATLDF
                     ELNDLSGLSGLDGLSAPNDPAGRPAPYDDGPHPASPLEELEAGGITVWADSGAVDISGP
                     DIPRTRLCFAHVVSDPQPLLGLVRAGIPVFDTGEVRRTLDPSRRDAHRDTPRGAPRDAA
                     RDRSADRGPAGRGRQGRRSA"
     gene            complement(15474..15608)
                     /gene="botA"
                     /locus_tag="JIX56_RS29160"
                     /old_locus_tag="JIX56_29160"
     CDS             complement(15474..15608)
                     /codon_start=1
                     /gene="botA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486703.1"
                     /locus_tag="JIX56_RS29160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29160"
                     /product="bottromycin family RiPP peptide"
                     /protein_id="WP_005486703.1"
                     /transl_table=11
                     /translation="MGPVVVFDCMTADFLNDDPNNAELSALEMEELESWGAWDGEATS"
     gene            complement(15705..17627)
                     /locus_tag="JIX56_RS29165"
                     /old_locus_tag="JIX56_29165"
     CDS             complement(15705..17627)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bottromycin_Methyltransferase_RRE"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000049: Methylation (99% identity)"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009298726.1"
                     /locus_tag="JIX56_RS29165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29165"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_257544950.1"
                     /sec_met_domain="TIGR03975 (E-value: 2.6e-157, bitscore:
                     523.9, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 3.3e-38, bitscore: 128.8, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAAKNVSLVSMPWNSVIRPSIQVGILRSLAESEGWQVDARYSYL
                     DFYGLAQRMLGFSDEKWSEAYELVSEKLYHLSVGDWIFSCRRGDAERREAYFAQLRARR
                     VDDTSIELVDALREVADRHVERTAAELLESAPDVVGFTSMFSQNGPSLAVAERLRDLGY
                     GGVIVLGGSNCEGSMGRALLANYPAVDAIVDGPGEDAFVALLRQVGAGGPLRTRGRLVT
                     RLPADDDAAPAAPLTAAALDVPTPNYDGFFEQLHAAGLHGLEPEITLPVEFSRGCWWGA
                     KTHCTFCGLNGATMAYRSKNPDTVADELRHLMDRYGVLDFFAVDNILDLKYLDTALPSV
                     EKLNTDHSLFFEVKANMEWADIRAVRRAGVRSVQPGIESLSTEGLRHLRKGATAYQNIR
                     FLLGCAEYGVRADWNILTGYPHETPDSLKAQLDVVASLTHLTPPHITLIRFDRFSPYVE
                     APESYGLTLTSPLPGYQYAYPRLSPEDLWDIAYHFEGDFTDDPDNGPVRRRLAARVRLW
                     RAHHDSARFSYRLGFDSVTLTDERPGLPPHTTTLRGEEARLFRAVVGGTRFRDLQGQEW
                     QGERWDQALETLRTWRRKRWVYIEGTKVIALAVREQPSAYRTPPPKGTPRRARTPVPLT
                     LTARP"
     aSDomain        complement(15822..16049)
                     /aSDomain="Bottromycin_Methyltransferase_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing methyltransferase protein in a
                     bottromycin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JIX56_RS29165_Bottromycin_Methyltrans
                     ferase_RRE.1"
                     /evalue="9.70E-41"
                     /identifier="RREFam008.1"
                     /label="JIX56_RS29165"
                     /locus_tag="JIX56_RS29165"
                     /protein_end="602"
                     /protein_start="526"
                     /score="128.8"
                     /tool="antismash"
                     /translation="SYRLGFDSVTLTDERPGLPPHTTTLRGEEARLFRAVVGGTRFRDL
                     QGQEWQGERWDQALETLRTWRRKRWVYIEGT"
     misc_feature    17681..17696
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            18033..18872
                     /locus_tag="JIX56_RS29170"
                     /old_locus_tag="JIX56_29170"
     CDS             18033..18872
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000045: Methylation (99% identity)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009298713.1"
                     /locus_tag="JIX56_RS29170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29170"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_257544951.1"
                     /transl_table=11
                     /translation="MKISLTGAAETLLAPLYARALDARSAHPLLGDHIAAELLDRIDYD
                     FDRLGMGEASAVGVALRARYFDRRVRAFLDAHPESTVVHLGCGLDSRFERLAPGPGVRW
                     FDLDQPDVIELRKQLYPARPGHETLATSVTEPDWPAQVPTDRPVLVVAEGLSMYLSADE
                     GPRMLRTLVAHFPQGELLFDTYSRFAVRSTRSLTLFRKTGARLAWGVNDPRELERGIPG
                     LRLIETDSAYATAAGVDVSHLPRTLRRRMRIDTHILARLPVLRHIGHISRYAFGPPA"
     gene            19142..20437
                     /locus_tag="JIX56_RS29175"
                     /old_locus_tag="JIX56_29175"
     CDS             19142..20437
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486693.1"
                     /locus_tag="JIX56_RS29175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_29175"
                     /product="MFS transporter"
                     /protein_id="WP_257544952.1"
                     /transl_table=11
                     /translation="MLPLYLISHGLSLLGNTVASIALPWLVLLRTGDATAVGLVAAASA
                     LPMLLSAVAGGVLIDRVGRRRLSIGADLASAACVAALPVVDGLLGLTVVWFVVLGVAGA
                     VFDVPGMTAREALAPDIAEATGIGMERLAGLRESIAGGVVILAPAAAGGLIMLVDPATV
                     LWLTAGCSALAALVTLALPKTIGAQPTATAQGDGAGLRGDLKRGLGVLRGDRVLTAVTL
                     VSAGSVAVLAPLQNLVLPVHLVGKDSPGGFGVVVSLLAVGGIAGAGLYAAIGTRWSRRT
                     VFVAAQLTSTIGIAGLALLPPVPVMWAAAVLAGAGAGPLPALFLVLVTERIPEEVRGRV
                     LGLQNAVSMTAVPLGTLVAGLTVDRIGLRQTGALLAIAWCAVTLAIVALPALRNLDAGR
                     AKSEPPAEDQPTPDGGSPIPGQGSETADTPTA"
     misc_feature    complement(20640..20655)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.86"
                     /tool="antismash"
ORIGIN
        1 cgaaagggcg gccgtcagtt cgacaggcgg cggatctggt cccacagcac cgggtccacc
       61 acccccgcct tcctccggaa gtcacccacg ggcacctcac gcagctcccc cgtctccagg
      121 aagctgggac ggccgcgggc atcgccgacc gtgcccggcg ggaggggaat cacaccggcc
      181 cgctcgtcgc ggtaccgact ggtgatcttg gccacgcggg cgcggtcccc gcggacggcc
      241 aggacgaggc aggggcggtc cttgccgccg ggcccgtcct cgaaggggac gctggcccac
      301 cagatctcgg acggccgggg ccgcggcacg ggcccgcgcg cccgcccggg gcgccccggc
      361 ggccgcgtcc gcccacccgg ccgctccgat cgcctcgacg gccgtcgcga ccgcccccac
      421 ccgtcgacca cggtcgcgag cagcgccagc agcaccaccg ccgcgagcgc caaccaccag
      481 gacgtgtcca tagcccgacg gtaccggcgc acaccgcgcc acgcccgccc tgtcgcacgc
      541 tcccgcgccc ttcggtgcca cctcaccccg gcccacgcgc gccccaacgg ccccaccacc
      601 agccgaaccg gtgacagcac aggtgagttc gcccacaaca gcccctggcg gaggagcgac
      661 ccaccctttt gcgccttacg ctcatcggac cgcacaaccc ttgctgcacc cacgtccgtc
      721 cttggcaacc ccgccaactg caatccgcac cacgcatccg tcacgcactc tgcaatccgc
      781 aacccgtctg cacgtcacga ctgacacgac tgtcacgact tcacgccagc gcggaggttc
      841 cagctctcat gaagctcacc gtcgtcggct gctcggggtc gttcccgtcc gcggaatcgg
      901 cctgttcgag ctacctcgta gaggccgacg gcttccggct gcttctcgac atgggtaacg
      961 gtgccctggg cgagctgcag cgccactgcg gtctctacga cctcgacgcg atcttcctca
     1021 gccatctgca cgccgaccac tgcatcgaca tgtgcgcgta cttcgtcgcg cgctactacc
     1081 gccatgacgg cggccgctgc gaccccatcc cggtctacgg accggagggc accgagcagc
     1141 gtctgaccac ggcctacgcc gacaccccgt cggcctcctc catgagcgag gtcttcgact
     1201 tccacacggt caagccgagc acgttcgagc tgggcccctt caccatccac accgaacggg
     1261 tcgcccaccc cgtcgaggcg tacggcatcc ggatcgagca cggcggccgg gtcctgacgt
     1321 actccgggga caccggtgtc acccacaccc tggacgaact ggcccgcgac agcgacctgt
     1381 tcctgtgcga ggccgccttc acccacggca aggagaacat cccggacctc cacctcaacg
     1441 gccgcgaggc cggtgagacg gccgcccggg cgggcgcccg ccgtctcgtc ctcacgcaca
     1501 tcccgccgtg gaccgacccg caggtcaacc tggtcgacgc ccgcgaggtg tacgacggcc
     1561 cggtggagct ggcggtgccc aggatgtcgt acgagatctg accccgtacg ttcgtacgcc
     1621 cgtacgcatg aagagggccc ccggagcgag acgctccggg ggcccgacgt cgtttccggg
     1681 gctgctcacg ccttggtgag gtcctcgatc tcctcgtcgg gctcgcggcc cggggtgggg
     1741 aggttgaacc tgacgatggc gaagcggaag acgacgtagt agatggcgcc gaacaccagg
     1801 ccgatgggga tgatcagcca gggtttggtg gccaggttcc agttcagggc gtagtcgatg
     1861 aagccggcgg agaagttgaa gccggcgtgg acgcccagcc cccaggtgat ggccatggag
     1921 agcgcggtca gcagcgcgtg gatcacgtag aggagcgggg cgatgaacat gaacgagaac
     1981 tcgatcggct cggtcacacc cgtcacgaag gaggtcaggg cgagcgagat catcatgccc
     2041 gtgacgacct tgcggcgctc ggggcgggcg gtgtgcgcga tggccagggc cgcggccggg
     2101 aggccgaaca tcatgatcgg gaagaagccg gacatgaaca ttccggcggt tgggtcgccg
     2161 gccaggaagc ggctcaggtc gccgtgcgag accacgccgg aggcgtcctt gaactcaccg
     2221 agctggaacc acgccaccgt gttgacgaac tggtgcatgc cgatcgggat gagcgcccgg
     2281 ttgatcgcgc cgaacagggc cgcgccggcc gaaccgaggc cggtcatcca ctcgccgaag
     2341 ctgccgatga cctcaccgat cggctcccag acgagcccga agaagacacc gaccgcgaca
     2401 ccgacgaagg ccatgatgat cggcaccagg cggcggccgt tgaagaagcc gagccagtcg
     2461 ggcagcttct tgcggtggta ccgctgccac aggaccgccg agagcagacc catgacgatg
     2521 ccgccgagga caccggggtt gttgtacgtc gcggcgacgt ccgcgccctt ggtgatctcg
     2581 gcctcggtca ccgggaacgc ttccaggacc ttgctgtaga ccaggaagcc caccagcgcg
     2641 gcgagggcgg tggagccgtc ggccttcttg gcgaagccga tcgcgacgcc gatgcagaag
     2701 agcatcgcga ggttgccggt gatggcgccg cccgccttgt cgaagaccgc ggcgaccttg
     2761 tcccagccga ggccctcggc cccgaagacg tccggctggc cgagccggac cagcaggccc
     2821 gcggccggca gtacggcgat gggcagctgc aggctgcggc cgaccttctg caggccctgc
     2881 atcaggcctg atccccactt tttcgcgggc gccgccgagg gcgcggtggc ggtgctcata
     2941 gacttcctcc atcgggtggt ggtctacacc actcagtggt gtagacctgt tgtagcagat
     3001 ggggaagcga tcaggaaccc tcgattccta cccggcacgc ggacggctcg cagagtgccc
     3061 ggtgagagtt caggggacgt ccggtgagcc ttcggagagg gcgcgcagcg tctcgatcag
     3121 cgtgcgcacc gcgaacccgg taccgccgta cggcacttcg gcgtacgggc cctcgtcgtt
     3181 gtacgcgggc gcggcgatgt ccagatgggc ccaggggaca ccggcggcga cgaagtcctg
     3241 gaggaagagg gccgcctgga tcgtgtcgcc gtgccggtgc gagcagttca cccggtccgc
     3301 cacggcggag cgcaggttcc gccgctcatg ggcgagcagc ggcagccggc agaacgactc
     3361 cccggcccgc tccgaagcgg ccagcaccgt ctgggccagc tggtcgtccg gcgtgaacag
     3421 ggccccggtg cgggtgccga gcgcgtggac ggcggcggag gtgagggtgg ccacgtcgac
     3481 gacgaggtcg ctgcggtgcg ggccggggcg gctcgcgcgg accaggacgt cggccagcac
     3541 cacccggccc tcgttgtccg tgtgggtgat ctccgtggtc gtaccgtcca gatgccgtac
     3601 gacgtccccc acccgcaggg cgccgccgtc cggcatgttc tccgcgaggg ggaggtggcc
     3661 gcgtacccgc aggggcaggc cgaggcgggg cagtgcggtc agcgcggcga cgacggccgc
     3721 cgcgccgccc atgtcggcct tcatcgcgtg ccgctcgccg gacggtttca gggacagccc
     3781 gccggagtcg aacgtgacgc ccttgccgac caggccgacc gtgagggcag ggtcggcatc
     3841 cggcgggtcg tacgtcagct ccacgtaccg gggcggttcc gccgagcccc ggcccacggc
     3901 ggtcaggccc gtgaggccca gctccgtcag gccggctccc tcgtacaccg cgcagtcgag
     3961 gccggcggtg tgcgccagct cccggatccg gtcggcgaac gccgggggag tgagggtccc
     4021 ggccgggcag ttgacgaggt cgcgggccag acaggtggcc tcggcggcgg ccaggccctc
     4081 ggcgacggcc cgccgctccg gggtcgccac gatcacctcg gccagcggac tcgcggcccg
     4141 cgcggagcgg tactcgtcgt agcggtacag gcccagcacc gcgccctccg tcacggcccg
     4201 ggcccggtcg gcggccggga ccccgctgcc gtcggccagc gcgaggtcga ggcggagcgt
     4261 acgggcgggg cccgcggccc gtaccgaggc ggccgccgcg gcgcggaacg tggcggccgt
     4321 ggccgaaccg gcgggcccca ggcccacgtt gagcaccacc gcgcggccgt cggcggacgg
     4381 ctcggcgacc acctgcccgg gccgtgccac gaagccccgg cggcggctga aggcgccgac
     4441 ggccgcgccg gtgtgccggc cgtacgcgac gacgtcggcc gcccggctcg ccgtatcggc
     4501 tgtatctgcg gtatctgcgg tatctgcggt atcggccgta tccggcgtgt ccgtgccgac
     4561 gtcacccgcc acgacccgtg tcatgcggtc atacgcgttc gtactgcgtg cccgactcgt
     4621 cgcggcgcag caggttctcg tccacgagcg cccggcgcag ggtcacccag tcgtcgaacc
     4681 actggccgca gatcgcgttg accttggctt cggagtaggt gacaccggcc tcgaaggagt
     4741 cggccacgac ggtgagcacc cggctgcgga cctcggcctt gccggggatc gaggtcagcc
     4801 gtcccttgcg gaagtaggcc cccgcgccgt cgccgccgcc ccggccggag atcctgacct
     4861 ccgcctggac ggccagccgg aacgtgtcgt cgatcagccg gtaggtgcgg gcgtcggcgt
     4921 cgtacgcggc gatccgcccg tcgacgagct tctgcagggc gacggcggcg gcggccgggc
     4981 gcagccccgc ccgctccgcc acctgtgcca cggaggtcgc gccgagcgcg agagccgcga
     5041 aggcgtcgcg ccggtcggtc tgggcgagga tgccgatcag atcgcggcag gacggcggca
     5101 ggtcctcggc gcgggtctgg tcctcggtgg gggccgtggt catagtgatc aacttccggg
     5161 tcgtgatgcg gcgttgtgct cggtgctgcg tggtggtgtt ggtgtggtgt gtcgtgtgtg
     5221 gtgctcggag ctgtgcacag tgatcctcta cgagtaccgc gccgacgggc ggtcaccgca
     5281 aacgggaaac gccgtgcggg acggatttca gccaggccgc cgcggcggag gcggaccggt
     5341 gagcgtgagg ggtacggcag ttcgggaccg gcggggagtt cctttgcggg gcggggtccg
     5401 ataggcggag ggtttttcgc gtacggggag ggcgatgact ttcgtgccct cgatgtagac
     5461 ccaccttttc tcctgccagg tgtggagctt ttccaggggc tgcccgtctc gcccttcctg
     5521 attctggagg tcgcggaatc gggtgccgcc gatgatcgcg cggaagagcc gggcgtcctc
     5581 gtcgcgcagc acggtggtgt gggccggcag gccgggccgg tggtcggtga gggtgacgga
     5641 gtcgaagccg aggcggtagg tgaaacgggc ccggtggtgc tcggtgcgcc agtggtggac
     5701 ggccgtggcg aggcgttcgc ggacggcggt gttgcggggg tcctcggtga agtcgccctc
     5761 gaagtggtag gcgaggtccc acaggtcgcc gggggagaga cggggatagg cgtactggta
     5821 gccgggcagc gggtgggtca gggtgagacc gtagtcctgc gggtgttcca cgtacgggct
     5881 gaaccggtcg aagtgcacgg cgaggatgtc gttgtcgggt ggttccagat gggtcaggga
     5941 aggcagcaga tcgatctggg tgagcatcga ctccggggtt tcgtggggaa atccggtgag
     6001 gatgttccac accggcagga caccgaattc ggcgcagccg agcaggaaac ggatgttctg
     6061 gaaggcggtc gcgcctttct tcagcagtcg cagcccctcg gtgctgaggc tttcgattcc
     6121 cggctggacc gagcggactc cggcgcggcg ggcggcctgg atgtcggccc attccatgtt
     6181 ggccttgacc tcgaagaaca gggaatggtc ggtgttgagc ttttcgacca gcgggagtgc
     6241 cgtgtcgagg tatttgaggt cgaggatgtt gtcgacggcg aagaagtcga ggacgccgta
     6301 gcggtccatg aggtggcgga gttcgtcggc gacggtgtcg gggttcttgc tgcggtacgt
     6361 catggtcgcg ccgttgaggc cgcagaaggt gcagtgggtt ttcgcgcccc accagcagcc
     6421 gcgggagaac tccaccggaa gagtgatctc gggttcgagg gtgtgcaggc cggcggtgtg
     6481 caactgctcg aagaaaccgt cgtagtcggg ggtgggcacc tccagcgact gaccggcgga
     6541 catgccggcc ggggcgctgt cggcgagggc gggcagccgg gtgatcagtc ggccgtggga
     6601 gcgcggcggg tcgccggccc cgacctggcg gagcagggtc acgaaggcgt cctcgccggg
     6661 gccgtccacg atggcgtcca ccgccgggta gttggcgagc agggcgcggc ccatcgagcc
     6721 ctcgcagttg ctgccgccga gcacgatcac gccgccgtag ccgaggtccc gcaggcgctc
     6781 ggccacggcc agcgtcgggc cgttctggct gaaggtgctg gtgaatccga tgaggtcggg
     6841 ggctgattcc agcagctcgg cggccgtccg ctccacatgg cggtcggcca cctcgcgcag
     6901 cgcgtcgacc agctcgatcg tcgcgtcgtc gacgcccttg gtgcgcagca tccggaagta
     6961 cgcctcgcgc ggcgccgccc cgccgtcgcg gcacgcgaag atccagtcgc cgacggagag
     7021 ctggtacagc ccctcggaca ccgtctcgta cgcctgcgac cactcggcgt cccgcatgcc
     7081 gagggccgcg cgggcgaggc cgtagaagga gaggtaggcg tagtgcgagt cgacccgcca
     7141 cccctcggcg cgggcgacgg agcgcagggt gccgacctgg atggaggggc ggcggacgtt
     7201 gttccagggc atggagacga gggcgacccg gcctggtcgg gtgggcactg acggggtggt
     7261 gggctctgtc ggagtggtgg ccaaggtcgg ctcggtcgtg ccggtcgcct cggtcgtgcc
     7321 ggccgtgccg atcgcctcgg tcctctcggt cgttccggtc atggcgccct caccagacga
     7381 gcctcaggtc gtaggagttg cgcaggaacg gtggctcggc cgtgcgctgc tcgggggacg
     7441 gcgcgtagtc cgggacgagg gcgtgccact cctccagggc caccaggatc tgggcgcgcg
     7501 cgaaggccgc gccgaggcac tggtgggggc cggtgccgaa ggcgatgtgc gggttgcgcg
     7561 cccggtcgaa gtcgatccgg ccgggctccg ggaacacctc ggggtcgtgg ttggcgaggg
     7621 cgagcggaag cagcacggtg tcgccccggt ccgcgacccc gcccgcgccg ccggtcgcgg
     7681 cctgccggcc cgggtacatg cacgagttgg cccgcaggaa ctcctcgacc gccggcggcc
     7741 ggacctcggg accggcgagg aaccgccgcc ggtcctcctc gtggtgggcg aggtgctgga
     7801 cggcgttggc cagatggttc accgtcgagt cgatgccggc caggaacagc gtgcacagca
     7861 gggaggcacg gtcgtcgtcg gtgacctcgg caccgtcgat ctcccagccg aagctggcgg
     7921 tggtcaggtc gtcggcgggc tccgcgcgcc gccgggcgat gtgttcccgg gcgaaccgct
     7981 ccagcgccgg aagcccgagt tcgccgtacg ccgccgccct ggggtccggt gccgaacggg
     8041 agtcgatcat cgcccggttg atggcgatga gcaggtcgaa cccgtccggg ggccagccca
     8101 cggccgtcat caggttctcc aggacgtacg gccgggcgaa gtcctcgttg aacgacacct
     8161 cgcccttctc caggaacccc tcgatccgcc gccgggcgcc cgcacgcatc gacggggtca
     8221 gctcccgcac ccgctgcggg gtgaaccagg cacccagccg ctgccgccac gccgtgtgct
     8281 cgcggccctc gacggtcagc gggatccagc gctcctcctc ggcgccctcc gccgcgctga
     8341 cccgcccgac ggtgaacgtg ccctcgtcct tgaacgcgtc cacgatcccg tcgtacgtcg
     8401 tcagcaccca gaagccccgg tcgctgtaga aggcgccgtg ctcaccggcg tgttcggcgg
     8461 cggcgtcgcg atacgtctgc ggcgcggcga agaagtcgaa gtcgacgggg catgtggcct
     8521 gctgtggggg gtggtcgggt tctgcggggc gtttcgcctc ctgccccgtg cggtcgggtt
     8581 cccggtcagc ctgcatgggc tgtctccttc gtgggtcggc cggtggtgac cggtgggtcg
     8641 agggtgccgc gggcccagcc ggacgggtcg aggccggacg cggccaggcg tagcgcccac
     8701 aggcggtcga ggtcggtgcc gtcgaggagg actccgtcga cgagcaccgc gtcgggccgg
     8761 gccagggcgg tcacgtcgcc gtcgggcggc cgccggtaga ggaccaggtc cgccggatca
     8821 ccgggcaccg ggcccgcccg ccgccccatg gcctcgtacg cgtgagtggt cgccgcccgc
     8881 agtacggcgc cgaagtcgag ccccgcgcgg gacagttcgg ccagctcctt gtggaaggag
     8941 gggccggcga ggacgaacgg gttgccgcag tcggtgccgg ccagcagccg ggtgcccgtg
     9001 tcggcgaggg cgcgggcgat ccggcccagc tcgtcgacga ggccgccgcg ccggtgcacc
     9061 tcggcggcgt ccagccggag ggcgtcccgg gccgccgact gccaggaccg gcggcggccc
     9121 tcgtccaccg cctggagggc cgcgcgggag gggcgggtgt accggcgctc accgctgcgg
     9181 gcgcgccagc agacgagggt ggggcagacg aagtggccgg gtacggcgcc gggtgccggg
     9241 tggtcgcgca gggcagccgc cagcgcgtcc cagcgccgct cgggcggcag ccggaacaca
     9301 ttgggcacga tgccgtacag atgctcggac gaccgcaacg tgcgctgggc caggtccagg
     9361 ggcaccgcct cggggatgtg gcccacgacc ggcagcccgg cccgctcggc ctcccgcacc
     9421 aggacctcga acgccgggcg cgcgacgtcg tcgtacacct tgatcccgtc gaaaccgaac
     9481 gccagcgcgt cctcgatcac ctgccggacc gaccggaccc cgtccaccac ggtgaccccc
     9541 tgcgggatcc gcgacccggg cccgtcgacc accccggcgg tgacccaggg ccggggcagg
     9601 acggcgtgcc gggcgcggtg caccccggcg gcgtacagat gcgccggctc gccccacagc
     9661 tgccggaagc cggtgacacc gtggacgagg agaccgacca ggtcggcggc ggacgagaca
     9721 tgcgcgtggg agtcgacgag gcccggcacg gcgtacgagg tgtacggcgc cgcgcgcccg
     9781 tcggaggcgg gcggcgtcgg ggtccaggcg gtgaccgtgc cgtcggtcac cgtcagatcg
     9841 tgcgggggac cgggccgccc ggtggcgggg tcgacgagcc cgacggcccg cagccgatgc
     9901 ccgcgcccgc gctccgccag ctcctccagg gcccgcacca gcgggtcccc gtcgggcagc
     9961 agcccccggc gccgacgcca catggtgtcc tcggtcgccg tcatacgacc cccgtcccgg
    10021 acgcgcgggc ctcggccggt gcgtctccgg tcgtacgggc ctcacccggt gcgtctcccg
    10081 tcccgtgccc accctccgcc agtacccccg ccaccctccg cccgacctcc gcgagacgcc
    10141 ccgcggcctt gatgcgggtc ggggcgtcga cgagccacag gtgggcgccg aggcggcgct
    10201 ccccggcgtg gaagggggcc aggtcggcgt cgccgtcggc ggtgatcagt accaactcct
    10261 ggtcggggtg gccgcgttcg gtccgccggt cggagccgtg cagcagaccc cgcgtggccg
    10321 cccccagctc accggggtcg acgcgggcgc aggcctcgac catccacggc ggggcgcccc
    10381 gcccggtgaa gtggtcacgc agataggcgt gcccgccggg gccctcgacg gccaccgcct
    10441 cctcctcgac ggcgtcctcg gggatctcca cctgctcggc gtgcgcgcag aaggagaacg
    10501 cccgggccac ccgggtgtcc acggcggcga cctggagggc gatccgcccg ccgaagaacg
    10561 tgccgaacag gctgtaccgt gcgcggccga accggtccag gaccgcgcgg acgtcctcga
    10621 cgtaccggcg cagggcgtgg ccctccgccg tgccgacgcg cccgctctcc ccgcgtcccc
    10681 gcaggtcgag cgcgaggaca tgggcgtccg ggagcgcgtc gaggaacccc gactccgccc
    10741 agatccgccg gtccatggcc acaccgtgga cgaggacgac ggtctcgccc ggcccgggcc
    10801 tgctgaagcc ccggatcggc gtgccgtcgc gggagaacac ctcgaagacg tccctacggc
    10861 tcgtgccgtt accgtcccgc accgaccctc cccgatcccg caccggccat ccccgactcg
    10921 gcggcggccc gctccgactc ggccgcggct tcccgcagct ccgccgcccg gcccagctcg
    10981 tcccgcatgc cgtcgcgcac cgcgaggacg agaccgcgcc ggccctccag atggatccag
    11041 ccgcgccgcg cccactcccg taccgtcgcg tgcacctcgt cctccggccg gcccgtcatg
    11101 gcggcgacct ggccgacggc ctggtgcagc cgtccgccgt ggaccagaca gcggaacagc
    11161 tggtcgtcgc cgccccgcag cacatgccgc ccggtgccga cgtgcggccg gccgtcgtgc
    11221 agcacggtca tgttcggccc gaaccggaac gagaaccgcg actgatcgtg cagcttcttc
    11281 cacaggccca cccgggcccc gagacgccgc cgcagcgcca gcatctccgc ggccatggcg
    11341 gagtcgtccc gccccgccag ctccacatgg tcgaacgagt aggccagctc ggcgcgttcg
    11401 gcggcggtgc ggccggcgtg cacgaagcgg tacttcggct cgggcccgtc cagcgcgata
    11461 ccgaactcct cgggcttctc gaagtacggg ctgtagcggt cgacccggac cttgctcacc
    11521 gtcgacggcg gcgcgagatg cgtgatgaac gggatcagcc gcagctgctc ctgaagcatc
    11581 gccgccgtct cgtcgggcat cgccgacagc aggttccact gggcgtcgat gcccagctcc
    11641 tggcacagca ccaggaaacg caggttgtgg aaggccgtcg cccccttgcg cagcagcttc
    11701 agcgcaccgc tgctcaggct ctcgatgccc ggctgcacca tggtgacgcc cgccgcccgc
    11761 atctcgccca cctcacgcgg ccccagattg gccttcacct cgaagaacgt ggtgatgtcg
    11821 acctccgccg cggcgagttc ggcgaggccg ttgtcgttcc tcgcgaggat cgtgtcgacc
    11881 gcgtacgtgt cgaacacgcc gtgctcctcg gtcagccggc gcagggtctt ggtcagctgc
    11941 tcgcccggct tgctgcggta gaccatcccg ctgccgttct ccccgcagaa ggtgcactgc
    12001 agcttctcgc cccaccagca gccccgcgac atctggaacg ggagcgccac atgcggggcg
    12061 atcagctcac ggtgcggcag cgcccgcagc cgttcgaagt actccgcgta ccggggcacc
    12121 ggcgccgact cggccggctg caccgtcggc agcgacaccc gcagcccgcc ctcgtgccgc
    12181 aggaccagac ccggggccgc cgcgaggtcg tgggcgccgc gcgcggcccg gaccgccgcc
    12241 accgccgcct cgccctcgcc ctgcacgacc gcgtcgacga acgggtacgc ccgcatcacg
    12301 gcctgcccca tgggccggtc gcagttcgcc ccgccgagca gcaccagccg ctcgggcgcc
    12361 tggtccttga cggcccgggc gacggccagc gcgggcatca gctgactgaa cgacgtggtg
    12421 aacccgaagc actccgcgcc ggtcgccacg agccgcccgg cgagccccgc cgtgaacccg
    12481 ggcgccaccg cgcgcagcgc cagcacccgg cccaccaact cctcggccac accgtgctcg
    12541 gtgaggaagg cggcgtaccg gtcgcggacg tccgcctcct ccccgggacc atgggcgtcc
    12601 aggaccccgc cgaagatcca gtccccgacg ccgagcccgt acagctcctc gccgatcgtg
    12661 tcgtagacgg tgacgaactc cgccggatcg cactccagcg cgtcgacggc gtactcgaac
    12721 cagtccaggt acgcgtacac cggtgtgatc ggatcaccgt cccccgtgcc ctccagcgcc
    12781 gcgagggtgg cgatctggat ggacgggcga tacaggctgt tccagggtgg tgccacgagc
    12841 gcgagcttca ccggggcgca cctccgtggt cctttccgtg gtcctctccg tggttcttgc
    12901 gcggtcgcag ccgctcgccg agccgcccgg tcggcagcac cggatagccc gcccgcgcct
    12961 tgtcgaacat ctccaggccc ggcgcgacga cgtcgacgac cgtgacggac cccggcggcg
    13021 tgagcacccg gtggtggacg tccacgccca ggtcccgcag ccggtccacg agatgccgca
    13081 gcagctgctc ggggctcgcg gccgcgggca gcccgtcgtc cgcgtcgaac gcccgccgct
    13141 cgtgcggcag ttgaccgaca tcgaaccggg cggcggcgag atggcgggga tagcgggcca
    13201 gcgcggtggc gatctgcccg gcctcggtgt ccgcgtccac cggcccgtgc tcgaacatcg
    13261 tgcgcacctg gaggtattcg agcagggccc gctgcaacgc gtacgtccgc accggcgagg
    13321 ccccgctgcc gatcagccgc acctcctccc ggctccgcgc gtcgcacacc acataggccg
    13381 gtacgccggt gtcacaggtg atgtcgacga tcagcaccgg cgcctcgcgg acctgctcga
    13441 ccgtgccggt cagctcccgc agttcggcgg gcagcgtgtc gtggtcgacc acccgcagct
    13501 cgggcccctc gccgggcagc ccgaagtacg accgggccag ctggtacgac caggcgtccc
    13561 gctcgatcag ctcgttgacg gcgtgcacca gtgcctcgtg cacggtggcg cccgccgcgt
    13621 aaccggcgct ggaggtgtag tgccacagcg gctggaacga ccggtcgtcg tccgggtggg
    13681 gccagttgcg gtagccgccg tcacgcagga acacggggtg ccggtgcggc cgcccggccg
    13741 ggccgtggtc cgcccgcccg gtcagggtct cctccaccgg gcggtacgta cgggtcagca
    13801 cgggcgcgtc cggcatgatg ccgccgagcc ggcgcagcag cgcggaccgc cgggcggtgt
    13861 cctggcccgc gatctcccgg cccggcagga actccgcctc cgacgcccgc ggatcccggc
    13921 gccagtccag gtggtagtgc tcggcgctct cgaacagcgc gctcgccatg ctccggtgcc
    13981 ccagcccctt gccggagctg cgggaacaga gcgcgccccg ggcgtccgtc agccgcacct
    14041 cgtaggtcgg cgcggactcg atgccgtact tgcggatgtc ggccgtcagc cgctccgcgg
    14101 ccagccagtc cccgacggag gacagggcct gctggatggc cgtctcgcgc tcaggcggaa
    14161 cgtcgtcctt ggcggccccg tccagcaggg ccgcggtcag cagatcggtc tcgggctgcg
    14221 tctcggggtg cgcctcgggg tgtgtctcgg tgggcgtctc ggcgggacgg gtcaagggtc
    14281 ctcctcactt ctcccgtgtc gaacacgggg atgcctgcgc ggacaaggcc caggaggggc
    14341 tgcggatccg acaccacatg ggcgaagcag agacgggtcc tggggatgtc cgggcctgag
    14401 atgtcgacgg caccggagtc ggcccacacg gtgatgccgc cggcctccag ctcttccagg
    14461 ggggacgccg ggtgcggccc gtcgtcgtac ggcgccgggc ggccggccgg atcgttcgga
    14521 gcgctcaacc cgtcgagacc gctgagaccg ctcagatcgt tgagctcgaa gtccaaggtc
    14581 gcgcaccgcg tgagcagcgg ccaccgctcg aagcggcgca gaaagaaacg ctcggccggc
    14641 tcggcggtgg ggttcgaccg ccacatcgtc tcggcctgcg cgagctccag cagcgcccgg
    14701 tcggtcgcct cggcccgact cgccccgcag cccagcccgg tggccggcat cagccgcccg
    14761 cggccgtacg ccacggcgag cacggtcggc gtacggacgg cgccgcccag cggcaccacc
    14821 agcgtctcgt cacccgccga ccggggccgc gccgggcccg ccagacgacg gtgcaggaag
    14881 acgccgtagt cgatcagttc cgtcagctcc agcagcgccc cgcgcagggc cgcctcgggc
    14941 gtcggggcga cggcccagcc gaccgtgctc gacagccgtg cctccgcggc cgacagcgtg
    15001 cccgcgcgca gttcctcgcc ggcgacccag ggcgaggacc agtacagcgg cacccggcgc
    15061 ggtccgtccc cggacagcgg ccggtactcc cggctcgcac agccgtccgg cgcggtgcgt
    15121 accccggccg ccgggaaggg cgggaccgga ccggagcccg agccgggggc cggggtcgtc
    15181 ggcggacggg cgaccgttgc gaagggggtg cacgccacca gccgctccac ggcttccgac
    15241 agggccttcg cccgtgccac ggcctcggtc gtggcggtgc cgtagccgtc ggcctgggcg
    15301 gtgccctcgg cggggcgtac ggtgcaccgc acggtcaccg ttcgatccga cggatacgaa
    15361 cggtggacga cctcgcgcag ctcacactcc gtcgccgtcg cttcgagcat gctccctctc
    15421 ccggtggtcc gtctcgccga cttcacaccc gccggctact caccggccgg cgctcaagag
    15481 gtggcttcgc cgtcccaggc accccaggac tccagctcct ccatctccag agcgctcagt
    15541 tcggcgttgt tggggtcgtc gttgaggaaa tccgcggtca tgcagtcgaa tacgactacg
    15601 ggtcccatat ctcgatcctt tcgtcggtct ggcttgccgt tcgatttcgg ttccgtgcct
    15661 catggggtac gcggcggccc gcatccgcgc gatgggcggc ctccttacgg tcgagcggtg
    15721 agcgtgaggg gtacgggggt acgagcccgc cggggagtgc ccttgggcgg tggggtgcga
    15781 taggccgagg gctgctcgcg taccgccagt gcgatgacct tcgtgccttc gatgtagacc
    15841 caccgcttcc gccgccaggt gcgcagcgtt tccagggcct ggtcccagcg ttccccctgc
    15901 cactcctgcc cttggaggtc gcggaaccgg gtgccgccca cgacggcgcg gaacagccgc
    15961 gcctcctcgc cccgcagggt ggtggtgtgc ggcggcagcc cgggtcgttc gtcggtgagg
    16021 gtgaccgagt cgaaaccgag ccggtagctg aagcgggcgg agtcgtggtg cgcccgccac
    16081 agccggacgc gcgcggcgag ccgccgccgc acgggcccgt tgtcggggtc gtccgtgaag
    16141 tcaccctcga agtggtacgc gatgtcccac agatcctccg gagagaggcg gggataggcg
    16201 tactggtagc ccggcaacgg gctggtcagc gtgagcccgt agctctcggg cgcctcgacg
    16261 tacgggctga accggtcgaa gcggatcagt gtgatgtgcg gcggcgtcag atgcgtcagc
    16321 gacgcgacga cgtccagctg cgccttgagg gagtccggcg tctcgtgcgg atacccggtg
    16381 aggatgttcc agtccgcccg cacgccgtac tcggcgcagc ccagcaggaa ccggatgttc
    16441 tggtacgccg tggcaccctt cctgagatgc cgcagcccct ccgtgctgag gctctcgatc
    16501 cccggctgca cggaacggac ccccgcccgg cgcacggccc ggatgtcggc ccactccatg
    16561 ttggccttga cctcgaagaa cagcgagtgg tcggtgttga gcttctccac cgacggcagt
    16621 gccgtgtcga ggtacttgag gtccaggatg ttgtccaccg cgaagaagtc gagcaccccg
    16681 tagcggtcca tcagatgtcg cagctcgtcg gcgacggtgt cggggttctt gctccggtac
    16741 gccatggtcg cgccgttgag gccgcagaag gtgcagtggg tcttggcgcc ccaccagcag
    16801 ccgcgggaga actccaccgg aagggtgatc tcgggttcga ggccgtgcag accggcggcg
    16861 tgcaactgct cgaagaaccc gtcgtagttg ggggtgggta cgtccagggc ggcggcggtg
    16921 agcggggcgg ccggcgcggc gtcgtcgtcg gcgggcaggc gggtgaccag gcgtcctcgc
    16981 gtacggagcg ggccgccggc cccgacctgg cggagcaggg cgacgaaggc gtcctcgccg
    17041 gggccgtcca cgatggcgtc caccgcaggg tagttggcga gcagggcgcg gcccatcgag
    17101 ccctcgcagt tgctgccgcc gagcacgatc acgccgccgt agccgaggtc ccgcaggcgc
    17161 tccgcgaccg ccagcgacgg gccgttctgg ctgaacatcg aggtgaagcc gacgacgtcc
    17221 ggcgcggact ccagcagctc ggcggccgtc cgctccacat ggcggtcggc cacctcgcgc
    17281 agcgcgtcga ccagctcgat cgacgtgtcg tcgacccgcc tcgcccgcaa ctgggcgaag
    17341 tacgcctccc gccgctcggc atcaccccgg cggcacgaga agatccagtc gcccaccgaa
    17401 aggtggtaga gcttttcgga gaccagctca taagcctccg accacttctc gtcggagaac
    17461 cccagcattc tctgggccag tccgtagaaa tccagatagg aatatcgggc gtctacttgc
    17521 cagccttcac tctcggcgag cgagcgcaga ataccgacct gaatcgaagg ccggatgacg
    17581 ctgttccaag gcattgatac aagagaaacg tttttggcgg caggcacgaa aacaaccccc
    17641 ggagccggtt gcggcaactc gaatcaccgt agaaggggcc gattacgcga gtcaacagtg
    17701 cccaaagcat cggtataggt tggctggaaa cattcgtccg gcatgcaccc ctcgacaatg
    17761 cgtggccgag tatttgtgat caactccgtg atcgacgggg aaggtgcgca ggtcgtacgc
    17821 gtatacgcag gtgagatgcg tggtggacaa tgggaccggt cgggttgtac ggtgtatggt
    17881 gctccttgcg tatgctgtgt catgacgcgc cgggagtcga cgcgagctgt ccctgtcggt
    17941 cggaaaatcc ctgccgaggg ctttaccttg cgctcgccga atcaatattt cccgccgacc
    18001 ctatttctgt gcgcagagag gcgagaagtc gcgtgaagat ttccctgacc ggcgcggcgg
    18061 agaccctgct cgcacccctc tatgcccgcg cgctcgacgc ccgctccgcc caccccctgc
    18121 tgggcgacca catcgcggcc gaactgctgg accgcatcga ctacgacttc gaccgactcg
    18181 gcatgggaga ggcctccgcc gtcggcgtgg ccctgcgcgc ccgctatttc gaccggcggg
    18241 tccgcgcatt cctcgacgcg caccccgagt ccaccgtggt ccacctcggc tgcggcctcg
    18301 acagcaggtt cgagcgcctc gcccccggcc cgggcgtgcg ctggttcgac ctcgaccagc
    18361 ccgacgtcat cgaactgcgc aaacagctct accccgcccg ccccggccac gagaccctcg
    18421 ccacgtccgt caccgaaccg gactggccgg cccaggtccc caccgaccgc cccgtcctcg
    18481 tggtcgccga gggcctcagc atgtacctct ccgccgacga ggggccccgc atgctgcgca
    18541 ccctcgtcgc ccacttcccg cagggcgagc tgctgttcga cacgtactcc cggttcgccg
    18601 tacggtccac ccgctccctg accctcttcc gcaagacggg cgcccggctc gcctgggggg
    18661 tgaacgaccc acgcgaactg gagcgcggga tacccgggtt gcggctgatc gagaccgaca
    18721 gcgcgtacgc caccgcggcg ggcgtcgacg tgagccacct gccccgcaca ctgcggcgcc
    18781 ggatgcgcat cgacacccac atcctcgcca ggctcccggt actacgccac atcggccaca
    18841 tctcccgcta tgcgttcggc ccacctgcct gaacccgccg gagcccccgg cggaccgggg
    18901 gtcccggtca ctcgggggtc aggcctctcg ggaaggctcg acagatgggt agcccgggcc
    18961 acctgggaac cccgaccgcc ggaagacccc ggccatccgg ggaagcctcg gcaacccggg
    19021 ggcccgggcc acccgggacc ccggccgctg ggagacccgg actgccggga acccccggcc
    19081 acccggcggt gacgccggtc aaccatccga cgggccatcg gcccacgacc agaatgcccc
    19141 gatgctgccg ctctacctca tctcccacgg cctttccctg ctgggcaaca ccgtggcctc
    19201 gatcgccctg ccctggctgg tgctgctgcg caccggtgat gccaccgcgg tcggcctcgt
    19261 cgccgccgcg agcgccctgc cgatgctcct gtcggccgtc gccggcggcg tgctcatcga
    19321 ccgggtcggc cgccgccgcc tctccatcgg cgccgacctc gcctccgccg cctgcgtcgc
    19381 cgcactcccc gtcgtcgacg gcctcctcgg cctcaccgtc gtctggttcg tcgtcctcgg
    19441 agtcgccggc gccgtcttcg acgtacccgg catgaccgcc cgggaggccc tcgcaccgga
    19501 catcgccgaa gccaccggca tcggtatgga acgcctcgcc ggactccgcg agagcatcgc
    19561 cggcggcgtc gtgatcctcg ccccggccgc cgccggcgga ctcatcatgc tcgtcgaccc
    19621 ggcgaccgtc ctctggctca ccgccggctg ctcggccctc gccgcgctcg tcaccctcgc
    19681 cctcccgaag accatcggcg cccagcccac cgccacggcc cagggcgacg gcgccggact
    19741 gcgaggcgac ctcaagcgcg gactcggcgt cctgcgcggc gaccgcgtcc tcaccgccgt
    19801 caccctggtc tcggccggca gcgtcgccgt cctcgccccg ctccagaacc tggtgctccc
    19861 cgtccacctc gtgggcaagg actcacccgg cggcttcggc gtcgtggtct ccctcctcgc
    19921 cgtcggcggc atcgccggcg caggcctgta cgccgcgatc ggcacccgct ggtcacgccg
    19981 taccgtcttc gtggccgccc agctcacctc cacgatcggt atcgccgggc tcgcgctcct
    20041 gcccccggtg cccgtcatgt gggcggccgc cgtcctggcc ggcgccggcg cgggcccgct
    20101 gcccgccctc ttcctggtcc tcgtcaccga acggatcccc gaggaggtac gcggccgcgt
    20161 cctcggactc cagaacgccg tatcgatgac cgccgtcccg ctgggcaccc tcgtcgccgg
    20221 cctcaccgtc gaccggatcg gcctccgcca gaccggcgca ctcctcgcca tcgcctggtg
    20281 cgcggtcacc ctcgcgatcg tggccctgcc ggcactccgc aacctcgacg cgggccgtgc
    20341 caagtccgaa ccccccgcag aggatcagcc gacccccgac ggaggatccc ccatcccggg
    20401 ccagggctca gaaacggcgg ataccccgac ggcctgaact ccggagggcg ggggcgctgg
    20461 gcccgcaggg cccgcagggc ccgcgccccc gaaggggcgc ggggctgttt cgatgtgcgg
    20521 ctccgccgcg tgggcgcgac cagccacaac cgaccccggc cgcccgacaa caccacccgg
    20581 cacctccata ggcgcgacga cccagcagcc actcgcgttc atttggcgac ctttccccca
    20641 gtggtgtaga ccagtcgcgg gacagtcctg caagctgtcc ccgtacggtt ccgcggggaa
    20701 cgcggctcgg atcagggaaa cagggagcgt ggccatggcc agcaaggctg agaagatcgt
    20761 cgccggactc ggcggcctcg acaacatcga agaggtcgaa ggctgcatca cccgcctccg
    20821 caccgaggtc cacgacgcct ccctcgtgga cgaggccgcc ctcaaggccg ccggcgccca
    20881 cg
//
