LOCUS       NZ_CP102512            25248 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces sp. CA-210063 chromosome, complete genome.
ACCESSION   NZ_CP102512
VERSION     NZ_CP102512.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CA-210063
  ORGANISM  Streptomyces sp. CA-210063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10859970)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Jorgensen,T.S., Klitgaard,A.K.,
            Mourched,A.S., Blin,K., Oves-Costales,D., Genilloud,O., Larsen,T.O.,
            Tanner,D., Weber,T., Gotfredsen,C.H. and Charusanti,P.
  TITLE     Identification of the Biosynthetic Gene Cluster for Pyracrimycin A,
            an Antibiotic Produced by Streptomyces sp
  JOURNAL   ACS Chem Biol 17 (9), 2411-2417 (2022)
   PUBMED   36040247
REFERENCE   2  (bases 1 to 10859970)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Assembly Name                     :: M642_aaa1.6.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 55.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 11:12:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,501
            CDSs (total)                      :: 9,410
            Genes (coding)                    :: 9,051
            CDSs (with protein)               :: 9,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 141 of 359
            Pseudo Genes (incomplete)         :: 302 of 359
            Pseudo Genes (internal stop)      :: 23 of 359
            Pseudo Genes (multiple problems)  :: 101 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4948740
            Orig. end                         :: 4973988
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102512.1.
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25248
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="18"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25248
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25248
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15248](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15248
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(435..1916)
                     /locus_tag="JIX56_RS21425"
                     /old_locus_tag="JIX56_21425"
     CDS             complement(435..1916)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21425"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_257542823.1"
                     /sec_met_domain="ThiF (E-value: 2.3e-10, bitscore: 39.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDYSRSVRLGGLAAGVEESTLRERMDGISIHLTADGHLPAAAE
                     TLEVLVADLRRWPVRLSLDPGRGPARLDDELIRRLVETAAGIDPDRPLRIGEAQGKASL
                     HLHVGTAPPLGTAVAGTPDGHGVRLRHTGHPFPRLNAPGTGLGAVLTAAMLAGEAFKVV
                     AGLPEGKFQVIPVVDFCPVLPGEQPGIVVAPLPALERVLLGGGGAIGTGIALVLDLLQV
                     SGELTVVDREVFEKPNVTSYSIGTLADAAAGLPKVGLIDARLRRIEVTPFHGTIQASIE
                     AVDAGTLPWPRIVLGGLDSVEARHDLQRLQVDLILDGSTGGPVGTTVALHEALPTGPCL
                     RCYFKANHTGKSAEQRLHELTGLPLSRIARGQEPLTERDLESLDNQQRELVGQFLGRPV
                     CGLVNSAELTGGTEDGFRPSAAFVAQQAACLVVGAWIARSTGLVSGPPRRIEYDTRFGP
                     RPDQMIDHRLPTPGCVCQKDAALISLIREARRTRR"
     gene            complement(1906..2406)
                     /locus_tag="JIX56_RS21430"
                     /old_locus_tag="JIX56_21430"
     CDS             complement(1906..2406)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21430"
                     /product="Mov34/MPN/PAD-1 family protein"
                     /protein_id="WP_257542824.1"
                     /transl_table=11
                     /translation="MTTATRRLMLPAGAADPVLQEIRRHGLADQETGALLLTGQSDMHV
                     LVMAVAGTAGIVRGPGLFTVSAVAYDRLFTFAEERFYRVRAMIHSHPEEAFLSRTDRAY
                     SLRVPGFVSAVVPTYAAPPTDPASWGWWRFEQDWVPCTAPVVDPALPPVRTVMFDEEGV
                     REY"
     gene            complement(2403..2846)
                     /locus_tag="JIX56_RS21435"
                     /old_locus_tag="JIX56_21435"
     CDS             complement(2403..2846)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21435"
                     /product="hypothetical protein"
                     /protein_id="WP_257542825.1"
                     /transl_table=11
                     /translation="MDLESRLRLAGDIPAVEEFLSSAAGRLHHRKQDTDGLFWAEMQPN
                     NGERAAFIARIEWTVYPDRPPSLVFVESIGASGVGAPSAWPGANGYRYGSNDVCKPFTA
                     EGQRLHAEWSSGPHSWRSTGNPFLYVVENVQDDIDRVDGRRAG"
     gene            complement(2863..3126)
                     /locus_tag="JIX56_RS21440"
                     /old_locus_tag="JIX56_21440"
     CDS             complement(2863..3126)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21440"
                     /product="hypothetical protein"
                     /protein_id="WP_257542826.1"
                     /transl_table=11
                     /translation="MPQPHEIKITVTSALAEHPYQHDYDPQVTATSVLSDSLTAFGFTS
                     DGTTRYYLFHDGHEVPPEATVGELAGHAKALHLKLRTETTNG"
     gene            3262..3795
                     /locus_tag="JIX56_RS21445"
                     /old_locus_tag="JIX56_21445"
     CDS             3262..3795
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="JIX56_RS21445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21445"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_218780775.1"
                     /transl_table=11
                     /translation="MSPDRSQLPLPDPEMTGPDAVEQFDIAELGRLLKEHRGPLSLRQA
                     AAEAGVSFSTLTRVEAGAQPDLATFTRLCAWLGVSPSRFFTPTATRQVSPLDQAITHLH
                     ADPRLTDDAANKISSVLRDLYDALAKEAVPAVPALACHLRAASVLRPGVPQRLADLLTD
                     MNTELERLVEAGEL"
     gene            3792..4343
                     /locus_tag="JIX56_RS21450"
                     /old_locus_tag="JIX56_21450"
     CDS             3792..4343
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017885.4"
                     /locus_tag="JIX56_RS21450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21450"
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="WP_257542827.1"
                     /transl_table=11
                     /translation="MTLPRGFKANAEREALRLRRELDLSDTDALNVDDLAAHLKVKIVS
                     AEKLVSHTRLEELERVQAYAFSAATFQVSGRNVVVTNPLRTPGRRASDVAHELSHLVLK
                     HDLTEIREVNGMPFRTCRPDEEEQATAFGGTLMLPRPLLLGAVRRQWGPAQIAEHYGVT
                     EEMARYRYNTTGVAKQVRGR"
     gene            complement(4549..4869)
                     /locus_tag="JIX56_RS21455"
                     /old_locus_tag="JIX56_21455"
     CDS             complement(4549..4869)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21455"
                     /product="hypothetical protein"
                     /protein_id="WP_257542828.1"
                     /transl_table=11
                     /translation="MNGADEEKWSQLLTFTVGGRSSVVKQTAVRTGTVVVVVSGSVALL
                     DVQVAKAVDKAHGAGLPVFWAIACSCPTLPGLAPRANGERMSTAATEVRRTSLIVLLSH
                     DS"
     gene            complement(4890..5069)
                     /locus_tag="JIX56_RS21460"
                     /old_locus_tag="JIX56_21460"
     CDS             complement(4890..5069)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.4"
                     /locus_tag="JIX56_RS21460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21460"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_257551006.1"
                     /transl_table=11
                     /translation="MTPNWRTSSYTETQNCIEVADNDLTTVMVRDTKARGRGTIEVQRA
                     TWTAFVEHTRRRQH"
     gene            complement(5090..5944)
                     /locus_tag="JIX56_RS21465"
                     /old_locus_tag="JIX56_21465"
     CDS             complement(5090..5944)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056637.1"
                     /locus_tag="JIX56_RS21465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21465"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257542829.1"
                     /transl_table=11
                     /translation="MSTQVQEALQALGARLRGFRKDAGFASGRAFARATTWQESKVSRI
                     ENGKQRPSEDDIRVWCETTGQGDQLGDLVAIVRHVDELWLEWRRQLQTGVEKRQRQAIP
                     VYAKTKLFRIWHPTLIWGTLQTADYAAEVFQQGVSYYEIPNDTEAAVAKRLERQQYLYQ
                     GERIFNVLLGEQALYTNFGGPEVMKGQLDRLLAVMRLPRLSLGIVPKSAPTLIWPGNAF
                     SMFDSRLVLVETYSAEFSVSQPREIELYTKAFALLKQSAVYGTAVRDLISTAIQHYDQI
                     PND"
     gene            complement(5952..6476)
                     /locus_tag="JIX56_RS21470"
                     /old_locus_tag="JIX56_21470"
     CDS             complement(5952..6476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056638.1"
                     /locus_tag="JIX56_RS21470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21470"
                     /product="DUF6879 family protein"
                     /protein_id="WP_257542830.1"
                     /transl_table=11
                     /translation="MELISSAERNQLFESFAQDAFHLELRDDYSVPDEDSPFTSWLRGE
                     TVDYSYMEPWTRLIRRVTGEGKTVRRVRVVTEPHTPYIQWEHATTALNEEAGEEIRWLP
                     RHRLPENITFPVGGNDWWLYDDRLLAVGHFAPDGRVLGSELIEDPNTVAECVRLRDLLW
                     SAATPHPEYKP"
     gene            complement(6436..6855)
                     /locus_tag="JIX56_RS21475"
                     /old_locus_tag="JIX56_21475"
     CDS             complement(6436..6855)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010469724.1"
                     /locus_tag="JIX56_RS21475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21475"
                     /product="hypothetical protein"
                     /protein_id="WP_257542831.1"
                     /transl_table=11
                     /translation="MKLRFLGKNSTVGDCPTLYATDRDTYLVQGWKIFANDLLMQLEIP
                     EGETAVEVPTELFEHLTKDGLAVGEIRRVEDPIMILTPSGTFVVQGREVTDPEALAQME
                     IPDYETVVEVPKAAITALLEEPRGADLQRRAQPAL"
     misc_feature    6938..6954
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            7054..7422
                     /locus_tag="JIX56_RS21480"
                     /old_locus_tag="JIX56_21480"
     CDS             7054..7422
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056640.1"
                     /locus_tag="JIX56_RS21480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21480"
                     /product="hypothetical protein"
                     /protein_id="WP_257542832.1"
                     /transl_table=11
                     /translation="MTTVTDRRKAPAVDNQPIDTELIADSTDAALRMKLGTSTRESIDI
                     RTTAVIEQLNRLLGMDLGADEDPDIRHLVRRANKLLDLSERPTKETPAFSAFFYMRDVA
                     SLTRRLLWVCPEAGGHAP"
     gene            8224..8394
                     /locus_tag="JIX56_RS21485"
                     /old_locus_tag="JIX56_21485"
     CDS             8224..8394
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955488.1"
                     /locus_tag="JIX56_RS21485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21485"
                     /product="hypothetical protein"
                     /protein_id="WP_172638966.1"
                     /transl_table=11
                     /translation="MATEEPDDDTLFDLIGAVGAGINASKDEGLPLDVRELAADLADNT
                     ADRLAQFKKTT"
     misc_feature    8402..8420
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.66"
                     /tool="antismash"
     misc_feature    complement(8405..8420)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.87"
                     /tool="antismash"
     gene            8415..9662
                     /gene="fxlM"
                     /locus_tag="JIX56_RS21490"
                     /old_locus_tag="JIX56_21490"
     CDS             8415..9662
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009334866.1"
                     /locus_tag="JIX56_RS21490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21490"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_257542833.1"
                     /sec_met_domain="PCMT (E-value: 3.3e-40, bitscore: 137.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDTPAPTSEKHNAPASEQQMRGAMVERLIELGAARSGRVVAAFR
                     SVPRHLATPEVDMAKTYEAEFAPVTKTDATGVNISSVSAPRIQAMQIEQADIQPGMNVL
                     EIGSGGVNAAYLAEMVGERGHVVTMDIDHDVTQRAKDFLKATDYDRIVTVITADGEHGV
                     PGHAPYDRIVVTVQAADIPPAWVHQLKEGGRLVVPLRMRGMTRTVAFVRDRERLVSDGF
                     ELCGFVPMQGVGENRVRLVLLHDVEGEEIALRLDGHPEPDAEALRVALGMPRVEAWSGV
                     TVAGDESVEHLDLWLTTALDNLPLMAAKVGARKRGLVASASPIGVPTLVDGDSFAYRTA
                     RPTDEPDRYELGAIGHGPQGQKVADRLAEGIQVWHSDHRAHRAYIEVHPAGTPDDRLPA
                     GRLVDRPHTRVTITWP"
     gene            9733..9927
                     /locus_tag="JIX56_RS21495"
                     /old_locus_tag="JIX56_21495"
     CDS             9733..9927
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="JIX56_RS21495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21495"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_220647796.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 8.2e-13, bitscore:
                     47.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQQNPTTTLKAATDYSTNTGSDFDLNIETLASAPVIGSLLNDTS
                     DNCTSTCQSACTNSTCIGG"
     CDS_motif       9733..9852
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAQQNPTTTLKAATDYSTNTGSDFDLNIETLASAPVIGSL"
                     /locus_tag="JIX56_RS21495_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9853..9927
                     /prepeptide="core"
                     /locus_tag="JIX56_RS21495_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.50"
                     /molecular_weight="2234.3"
                     /monoisotopic_mass="2232.9"
                     /core_sequence="LNDTSDNCTSTCQSACTNSTCIGG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAQQNPTTTLKAATDYSTNTGSDFDLNIETLASAPVIGSL"
                     /leader_location="[9732:9852](+)"
                     /alternative_weights="2252.4"
                     /alternative_weights="2270.4"
                     /alternative_weights="2288.4"
                     /alternative_weights="2306.4"
                     /alternative_weights="2324.4"
     misc_feature    9979..9995
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.11"
                     /tool="antismash"
     gene            10001..13048
                     /locus_tag="JIX56_RS21500"
                     /old_locus_tag="JIX56_21500"
     CDS             10001..13048
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319705.1"
                     /locus_tag="JIX56_RS21500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21500"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_257542834.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-183, bitscore:
                     611.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.1e-18,
                     bitscore: 64.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.5e-32, bitscore:
                     110.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYHAFDASMIRTSVFPLAATLPPWPDLDGETPADVERWRDWIAQV
                     WSDDTRAAAIEFAAPLLAAAIRDVLDGKRQRPRPVRRTAASLARYLLRMQHRATPFGLF
                     AGPAPVSIGGTARVKWGKEHRAFARADAEWLNAAITALEGNREVLRRLPAMADPTCTVR
                     GTRVAVPHQSCTNGPTDTTLRRTRAVEAVLTLARTPIMVGDLVVKLHGDYPDTPTAVIE
                     DMVSSLVAHRVLLTSLHAPMTCDDALGHLIAQLDATGAAATSGGAETAEELRKIHQLLT
                     LHDIAAQGEQQALRVQAAARMNTLTDATTHTLVVNVRPDCDIVLPTAVTCEAERALEVV
                     SRISPYPNGSPAWQDYRARFLERYSMGAIVPLRDLTDPDTGLGFPVGYRGTVLKRPVLA
                     TTRRDDHLLALAQSAALNDRREVVLTEEDIEAMSLGEPTQAPAHVELCFTVLSPSLEDL
                     EHGRFELVTAGLSLAAGTTTGRFLTMLDQSDRERMTAEYAALPTLAAGAVRGQVSSPPL
                     RIPTRNVGRAPSVVPHVLSVSEHNPDATLDLDDLGVVADSRRLYLLSLSTGQLIEPSVM
                     NAVELSSATHPLVRFVTELHRSHTAILTPFAWGAAARLPFLPEVRVGRTILSAACWRLN
                     AHDLSGDSRDWTFRFTDWRIRYGVPRTVYVGGNDQRLRLDLDISAHRQLLRAELNRHGT
                     VTLHEAPDEAAFGWVGHAHEITASFASDQPPSLAPINRTATVVRHDSSRLPGAGEWAYL
                     KLYGNADRAPELLTAHLPSLLHGWDADAPTWWFTRYNDPDSHLRLRLRLPNPNTFGAVA
                     QQVAAWAGELRTEGLLQRVQWDTDEPETGRYGTGPALTAAEQVFAADSAAALAQMALPI
                     PDSLRPAVTASSFVDIADAFLGSPADGRAWLTTNLLKNDGEATTRDVLSAAVHLSAPGP
                     DHAALQALPHGEHLATTWALRRTALTAYRQALEAHGADPATVLPSLLHMHHNRAAGIAP
                     DSEAICRRLARAAALSWTAREEGALR"
     misc_feature    complement(10002..10017)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
     aSDomain        10466..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JIX56_RS21500_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-20"
                     /identifier="RREFam001.1"
                     /label="JIX56_RS21500"
                     /locus_tag="JIX56_RS21500"
                     /protein_end="241"
                     /protein_start="155"
                     /score="64.4"
                     /tool="antismash"
                     /translation="ADPTCTVRGTRVAVPHQSCTNGPTDTTLRRTRAVEAVLTLARTPI
                     MVGDLVVKLHGDYPDTPTAVIEDMVSSLVAHRVLLTSLHAP"
     gene            13045..14193
                     /locus_tag="JIX56_RS21505"
                     /old_locus_tag="JIX56_21505"
     CDS             13045..14193
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326102.1"
                     /locus_tag="JIX56_RS21505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21505"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_257542835.1"
                     /sec_met_domain="LANC_like (E-value: 5.8e-44, bitscore:
                     149.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPPALDTDATLRQSLARGSLGIALLHVERARQGTGSWQTAHQ
                     QLTDIGPLLDGNETGLFLGAPAMAYVLHWTTVDSNRYTGALQTLDRIVAAHIQRRLAAA
                     HARIDRGEPTTFAEYDLLRGLTGLGALLLRRAPKGNELKGVLEYLVRLTEPLHTADGRT
                     RLGWWVSHSPVNLTAPASDGHANAGLAHGITGPLALLALAKIRGTTVPGHETAMLRICR
                     WLDQIRVNDHRGTRWPRWITETTPVPPHLAAPSWCYGTPGLARAQQLAALALNDPDRKR
                     MAERALLYCLADPTQLDQLTSRGLCHGLGGLLRVVQRVTQDADEPRAFAHHLPQLSERF
                     LTTEPPTETGFLNGSVGATLAVQNIQEGALPTSDWDACLLLI"
     gene            14238..15248
                     /locus_tag="JIX56_RS21510"
                     /old_locus_tag="JIX56_21510"
     CDS             14238..15248
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326099.1"
                     /locus_tag="JIX56_RS21510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21510"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_257542836.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.7e-26, bitscore:
                     91.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEQAILAVLTGTPLTEAAGRAQTSPEHLAETTERYRDAGRSALD
                     PQLSGWHQVNIEFTDYPTAERTFGAYLLPALRTGPIGAWWFVRKYPWWRLRVQPGPGTR
                     VEDAVAHLTEVLDRALSWGVAMRWWPFLYEPETIAFGGPHGMTLAHTLFHTDSVGVLDY
                     HQHLTHSTSVLPGPKETSLLVTTLMLRAAGLEWGEQGDVWGQVEARRPLPTDVDPDQVS
                     TMVAPVQRLLTLDAGSALTDGPLAPLGNWVTGVERSGQALVDAARAGTLQLGLRGILAR
                     HILFHWNRMGFTTRQQAIYSRAARETILGGRESPWPRPFTSLSDNREAPLFHRPR"
     gene            complement(15533..16357)
                     /locus_tag="JIX56_RS21515"
                     /old_locus_tag="JIX56_21515"
     CDS             complement(15533..16357)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604110.1"
                     /locus_tag="JIX56_RS21515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_21515"
                     /product="hypothetical protein"
                     /protein_id="WP_257542837.1"
                     /transl_table=11
                     /translation="MQREDVLYQVARRALAIKMIVPVATSVSAGGALATTIERTTWHVW
                     RDALAIGALMAPLLITAVVASLVTNQGMQRWTTEAVTVTARRAYEALLQPLEVTGKEPP
                     TATPFNSPHVAAVRALEDFAIALERYAVQRALPDGRNPMPQVIARFSAAAALVRELRDG
                     VELDRIDGAKRTLLEVERILKVLSSGRLYDLAPGGESGDGLLHSHRERKAWRQQVLRGA
                     AFTLCLAGIVFALASSAVGVALATAVAAGLVVTWDKILRLSTSGDASGTTSS"
     misc_feature    16462..16476
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.18"
                     /tool="antismash"
     gene            16702..17475
                     /locus_tag="JIX56_RS21520"
                     /old_locus_tag="JIX56_21520"
     CDS             16702..17475
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21520"
                     /product="hypothetical protein"
                     /protein_id="WP_257542838.1"
                     /transl_table=11
                     /translation="MRYEQRPLMPQPGAFPDEKALSAVVLGKLDRWFHIEEQIPGRYWT
                     GEETRIDAVLRPRDPKGWHDDAPAFGVEFKNPTPNTSTGHRYGWVTQAVGYAHCEWQGY
                     GRLGIFLCPSPLSWLLSRADEVASARQKRIGPESLEQERVRVREYGRLFGKEYSDAYVD
                     REALLAHRRTLGELTYEEFTARADGFVNADERQQEHDLRMADELTHLIGQLGVGELMPY
                     EKIGWALTRSGMRLWSEQDGVTRVPFQLRPRIGSR"
     gene            complement(17764..18603)
                     /locus_tag="JIX56_RS21525"
                     /old_locus_tag="JIX56_21525"
     CDS             complement(17764..18603)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21525"
                     /product="hypothetical protein"
                     /protein_id="WP_257542839.1"
                     /transl_table=11
                     /translation="MTEQAASPLRAHDAWALPVEVLGDILGVTFSERELIDDHQAWLIA
                     LRGRILVITVPGLSEEAKKHRIRRLFAEHIGHGWAAITVDSEEEVTFAETFLEEVDPED
                     VPAVDPPEVRTKQSKEVRELYEGSAYAPLHGWRSDEESIAALRTLITDALAGTAEDMPE
                     EVYPLPDGVGAMVAIGYDDQGVLHPLVWVRTDIPSGLRADLWGYCAALSASLDRVDAEP
                     DENGIFYVGMERSPVTGPGVALLAAVIAQRMGRRPEDCAFPLLAPPAQAEEAPPLAA"
     misc_feature    18768..18779
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            18905..20419
                     /locus_tag="JIX56_RS21530"
                     /old_locus_tag="JIX56_21530"
     CDS             18905..20419
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21530"
                     /product="hypothetical protein"
                     /protein_id="WP_257542840.1"
                     /transl_table=11
                     /translation="MKSTGSPLTSTAARRRRTLAHLSPIFEVHLNRARNPSSVQWEAYD
                     FVALIQSCVDMIALSSGLEGNLGAPRDEVLADMARVSGSMAPHRPAEEHAHVARHLLDH
                     LLRHAEPTPYFNVEYADPDSSWQPVPLQVRVLYETLAADGRALYVNADNTAVTLLLIAT
                     NRSLEDEHEAVIAVMRAQAESGRLDAAIDSAEDALTLSRTYAANVRRMIAEAERDVTRV
                     DYLRVLRPELVAAAAHLERRISVDGTLLRHLENLRADASEEQEPVAVRQLSVAASRLGD
                     AVETLAVLQTDVIGAAPRWREAQAAQAFSAVPVSEIDPTADVLSALLGGLPLPRGAELS
                     PPAPRVLLDVAALADRLAVPPKQVPEPDAAPIVDEPLEDADGVYEQFPEQFHDVAHVLR
                     AHRIMPGAKARLTDLLADADRLFAAEGPSAVVDGLVAVVGGSRDTARRRLRLLLALDAM
                     MLWRPDGWPDASDEWWALDDGIRGVFADLDVPDVLVCRKEDEDDSS"
     gene            20469..21197
                     /locus_tag="JIX56_RS21535"
                     /old_locus_tag="JIX56_21535"
     CDS             20469..21197
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS21535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_21535"
                     /product="hypothetical protein"
                     /protein_id="WP_257542841.1"
                     /transl_table=11
                     /translation="MSPARHDLYSRLLDRFHTDPDLRTAFDETADGLGLRVLTADRSAG
                     LVLIAEPTSPLAVTDTSHWLRIRGTGDRAVYGLALGGATAWCYPTARAVREPGTRRVTA
                     LDVDRLVREHAATIETEEITLDGGLGEAWREYATNRKQVALTSSGRLKRDCTVRMCEDV
                     LLMLAAFGLVMVDRTVPPPRAELKVWRSTDRFRAHVATAGGPLVWQTIIGSQAPEEHRK
                     DSRDQSPHTDYGEPFDERGE"
     misc_feature    21805..21816
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    21821..21830
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(21988..22006)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.16"
                     /tool="antismash"
     misc_feature    22213..22226
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    complement(22761..22776)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.17"
                     /tool="antismash"
     misc_feature    complement(23889..23904)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.66"
                     /tool="antismash"
ORIGIN
        1 ccttcccgac ctcgccgaga ccatcctggc cgaaaccggc tgggacgcct tggccgcaac
       61 cctcgccgac gccgaacgca ccggccacaa tccccgcgcc ctgctcgccg aggccgccgc
      121 cgaccgggaa ctggacaccg ccgattccgt cagcgacgtt ctcgtctggc gtctgcgccg
      181 caccgcagat ctcccgttgt acgccccacc ccaggaagcc acccaggccg accgccccaa
      241 cgatcacatg cctgccgcgc agacaatgcc gatatcaccg acatcgcgga cacggcgccg
      301 ttgatcacgg cacgacgaac gcgttgaggg tgcctgaata gctcccggta aacagatgac
      361 gggcccgacc gcaccaaggt cgggcccgtc accacctgca cactccgccc cttgctgcca
      421 cctccagccg cgcgtcaacg gcgggtgcgt cgggcttctc ggatgaggct gatgagagca
      481 gcgtccttct ggcacacgca cccgggggtg ggaagtcggt ggtcgatcat ctggtcgggc
      541 cgggggccga agcgggtgtc gtactcgatg cgtcgtggag gcccgctgac caggcccgtg
      601 ctccgtgcga tccaggcacc gacgaccagg caggcggcct gctgggccac gaacgcggcc
      661 gaaggacgga acccgtcctc cgttccaccg gtcagctcag ccgagttgac cagcccgcac
      721 accggccgtc cgaggaactg cccgacgagc tcccgctgtt gattgtccag gctttccagg
      781 tcccgttcgg tcagcggctc ctgcccgcgg gcgattcggg atagcgggag cccggtcagt
      841 tcatgcagtc gttgctccgc gctcttcccg gtgtggttgg ccttgaagta gcagcgcaga
      901 caggggccgg tgggcagtgc ctcgtgcagg gcgacagtgg tgccgaccgg gccgccagtg
      961 ctcccgtcca ggatgagatc cacctgcagc cgctgcaggt cgtgccgggc ctcgacgctg
     1021 tccagcccgc cgaggacgat ccggggccac ggcagggtgc ccgcatcgac ggcctcgatg
     1081 gaagcctgga tcgtcccgtg gaacggggtc acctcgatcc gccgtaggcg tgcgtcgatc
     1141 aaccccacct tcggcaggcc agcagccgcg tcggccaggg taccgatgct gtacgaggtg
     1201 acgttcggtt tctcgaagac ctccctgtcc accaccgtca actcgccgga aacctgcagc
     1261 aggtccaaga ccagggcgat gccggtaccg atcgcaccgc ccccgcccag cagcacccgc
     1321 tccagcgcag gcagcggggc gacgacgatc ccgggctgct caccggggag gacggggcag
     1381 aagtccacca ccgggatcac ctgaaacttc ccctccggca gcccggcaac aaccttgaac
     1441 gcctcgccgg ccagcatcgc cgcagtgagg accgcgccca gcccggtgcc gggcgcgttg
     1501 agccggggga aaggatgacc ggtgtgccgc agacggaccc cgtgcccgtc cggcgtaccg
     1561 gccaccgcag tccccagcgg tggtgctgtt cccacgtgga gatgcagcga cgccttgccc
     1621 tgggcctcac cgatgcgaag aggccggtcc ggatcgatcc cggccgccgt ttccaccagc
     1681 ctgcggatga gttcgtcgtc gagccgtgcc ggtccgcggc cggggtccag actcagccgg
     1741 accggccacc ggcgaaggtc cgccaccagt acttcgagag tctcggcggc cgcgggcagg
     1801 tgcccgtccg cggtcaggtg gatcgagatg ccgtccatcc gctcccgcag ggtgctctct
     1861 tccacgccgg cggccaggcc gcccaggcgt acgctgcggc tgtagtcagt actcacggac
     1921 gccctcctcg tcgaacataa ccgttcgcac cgggggcagc gccgggtcga caaccggagc
     1981 ggtgcagggc acccagtcct gctcgaaacg ccaccacccc cacgacgccg ggtcggtggg
     2041 cggcgccgcg taggtcggga cgacagcgct aacgaaccct ggcacccgca acgagtacgc
     2101 gcggtcggtc cgcgacagga aagcctcctc ggggtgcgag tggatcatcg cccgcactcg
     2161 gtagaaccgt tcctcggcga aggtgaacag ccggtcgtac gcgaccgcgc tcaccgtgaa
     2221 cagacccgga ccccgcacga tccccgccgt cccggccacc gccatgacca gcacatgcat
     2281 gtccgactgc ccggtgagca gcagcgcgcc ggtctcctgg tcggccagcc cgtggcgccg
     2341 aatctcctgg agtaccgggt cggccgcgcc tgccggcagc atcagccttc tcgtggcggt
     2401 ggtcatccgg cacgcctccc gtcaacgcga tcgatgtcgt cttgcacgtt ctccaccacg
     2461 tacaggaagg gattgccggt gctcctccag gagtgcggcc cgctgctcca ctcggcgtgg
     2521 agcctctgac cttcggcggt gaacggcttg cacacgtcgt tggagccgta gcggtagcca
     2581 ttcgctcccg gccaggcact gggcgctccg actccggatg cgccgatcga ctcgacgaag
     2641 actagggagg gcggccggtc cgggtagacc gtccactcga tccgggcgat gaacgctgcg
     2701 cgctcaccgt tgttcggttg catctcggcc caaaacaggc cgtcggtgtc ctgcttgcgg
     2761 tggtggaggc ggccggcggc cgaggagagg aactcctcga ccgccgggat gtcgcccgcc
     2821 agccgcagac ggctctcgag atccacgact gactccccgg ctctagccgt tggtggtctc
     2881 ggtgcgcagc ttcaggtgca gggccttggc gtgcccggcc agctcgccca ccgttgcctc
     2941 gggcgggacc tcgtgcccgt cgtggaacag gtagtagcgg gtggtgccgt cgctcgtgaa
     3001 gccgaaggcg gtgaggctgt cggacagaac gctcgtggcg gttacctgcg ggtcgtagtc
     3061 gtgctggtac gggtgctcgg cgagggcgga ggtcaccgtg atcttgatct cgtggggctg
     3121 gggcataccg atctcctaaa gcgttcgggt gacacagggg cactctgctg attcagcaaa
     3181 gcgtcagtga gtccagtgtg atcatctctc cccgatgcag tcaagcttca acgccgcatc
     3241 gctgcgcgct acgctgcccg tatgagcccc gaccggagcc agctccccct cccggacccc
     3301 gaaatgaccg gaccggacgc tgtcgagcag ttcgacatcg ccgaactcgg acgcctgctg
     3361 aaggaacacc gcggccccct ttccctccgg caggccgccg ccgaagcggg cgtcagcttc
     3421 agcacgctca cccgggtcga agccggcgct cagcctgacc tcgccacctt cactcgcctc
     3481 tgcgcctggc tcggcgtctc cccgagccgc ttcttcaccc cgaccgccac ccgccaggtg
     3541 tcgcccctcg accaggccat cacccacctc cacgcagacc ctcggctcac cgacgacgcg
     3601 gcgaacaaga tcagctctgt tctgcgcgac ctctacgacg ccctcgcgaa ggaggcggtc
     3661 cccgccgtac ccgcccttgc ctgccacctc cgggctgcct cggtgctgcg ccctggcgtc
     3721 ccccagcggc tcgccgacct gctcaccgac atgaacaccg aactcgaacg actcgtcgaa
     3781 gcaggcgaac tgtgaccctc ccccgaggct tcaaggccaa cgccgaacga gaagcactcc
     3841 gactgcgccg cgaactcgac ctcagcgaca ccgacgccct gaacgtcgac gacctcgccg
     3901 cccacctcaa ggtcaagatc gtcagcgccg agaagctcgt cagccacacc cgcctcgaag
     3961 aactcgaacg ggtccaggcg tacgctttct ccgccgcgac cttccaggtc tccggcagga
     4021 acgtcgtcgt caccaacccg ctccgaaccc cgggtcgcag ggccagcgac gtggcccacg
     4081 agctctccca cctcgtcctg aagcacgacc tcaccgagat ccgcgaagtc aatggcatgc
     4141 ctttcaggac ctgccgcccc gacgaggaag aacaagccac tgcctttggc ggaacactca
     4201 tgcttccccg ccccctgctg ctcggcgcag tccgccgcca gtgggggccg gcgcagatcg
     4261 ccgagcacta cggagtgacc gaagagatgg cccggtaccg gtacaacacc actggggtgg
     4321 ccaaacaggt ccgaggccgc tgacggcacc ggaggtaggc gctgtcggtc tgccacttac
     4381 cgccgggacg tggcgcggga gcgggcaagt actgcggttg gcgggctctg tggcgcatgc
     4441 ccggcggcgc gagcgatgaa ggacgcgcgc gtacgtgcgg tgtgacggcc cgtcgatact
     4501 cagcgggcgc caggcggtcc taccgggcag ccgctcaagg aggatcgttc agctgtcgtg
     4561 cgacagcaga acgatcagcg atgtccgacg cacttccgtg gcggcggtgc tcatgcgctc
     4621 accgtttgcc cgtggggcca gccccggcaa tgtggggcag ctgcatgcga tagcccaaaa
     4681 aacaggcaag cccgcgccat gagccttgtc gacggccttc gccacctgga cgtctagcag
     4741 ggccacgctg ccagagacca ccacgaccac cgtcccggta cggacggctg tctgcttgac
     4801 cacgctgctg cgtccgccga cggtgaaggt gagcagctgg ctccacttct cctcgtcggc
     4861 accgttcaca gggccctacg cgaacgccat cagtgctgtc tccgcctggt gtgctccacg
     4921 aaagccgtcc acgtggcccg ttggacttcg atcgttcccc ggccgcgtgc cttggtgtcc
     4981 cgaaccatca ccgtggtcag gtcgttgtct gctacttcga tgcagttctg cgtttccgtg
     5041 taggagctgg ttcgccagtt cggggtcatc ggctgcacgg tgcgctctcc tagtcgttcg
     5101 ggatttggtc gtagtgctgg atcgccgtgg agatgaggtc tcggacggcg gtgccataga
     5161 ccgctgactg cttcaggagg gcgaacgcct tggtgtacag ctcgatttcg cggggctggg
     5221 agacggagaa ctccgccgag taagtctcga cgaggacgag tcggctgtcg aacatcgaga
     5281 acgcgttgcc cggccagatg agggtcgggg cggacttggg gacgatgccc aggctgaggc
     5341 ggggaaggcg catcaccgcc aggaggcggt cgagctggcc cttcatcact tctgggccgc
     5401 cgaagttggt gtagagggcc tgttcgccga ggaggacgtt gaagatgcgc tcgccctggt
     5461 acaggtactg ctggcgttcg aggcgcttgg ccacggccgc ttcggtgtcg ttgggtatct
     5521 cgtagtagct gacgccctgt tggaagacct cggcggcgta gtccgcggtc tggagggttc
     5581 cccagatgag tgtggggtgc cagatgcgga agagcttggt cttggcgtac accgggatgg
     5641 cttggcgctg tcgtttctcg acgccggtct ggagttgtcg gcgccattcg agccacagtt
     5701 cgtcgacgtg gcggacgatc gcgaccaggt cgccgagttg gtcgccctgc cctgtcgtct
     5761 cgcaccagac tcggatgtcg tcctcgctgg ggcgctgctt gccgttctcg atgcgggaga
     5821 ccttcgactc ctgccacgtg gtggcgcgcg cgaatgcccg gccgctggcg aatccggcgt
     5881 ccttgcggaa gccgcgcagc cgggcaccga gcgcttgcag tgcctcttgt acttgggtgc
     5941 tcactggtcg gtcagggctt gtactcgggg tgcggggtgg cggcggacca cagcaggtcc
     6001 cgtaggcgta cgcactcagc cacggtgttc gggtcctcga tcagttccga tccgagcacc
     6061 ctgccgtcgg gtgcgaagtg gcccacggcg agcaggcggt cgtcgtacag ccaccagtcg
     6121 ttgcctccca cggggaaggt gatgttctcc ggcaggcggt gccggggcag ccagcggatc
     6181 tcctcgccgg cctcctcgtt cagggcggtg gtggcgtgct cccactggat gtagggggtg
     6241 tgcggctctg tgaccactcg gacgcgtcgg acggttttcc cttcacccgt gacacgcctg
     6301 atgagtcgcg tccagggttc catgtaggag tagtcgacgg tctcgccgcg gagccagctc
     6361 gtgaacgggc tgtcctcgtc ggggacggag tagtcgtccc tcagctccag atggaatgcg
     6421 tcctgcgcga agctctcaaa gagctggttg cgctcggcgc tggagatcag ctccacgcgg
     6481 ttcctccagt agggcggtga tcgcggcctt ggggacctcg accacggtct cgtagtccgg
     6541 aatctccatc tgggccagcg cttcggggtc ggtcacctcg cggccctgga cgacgaacgt
     6601 accgctcggc gtcaggatca tgatcggatc ctcgacacgc ctgatctccc cgaccgccag
     6661 gccgtccttt gtgaggtgct cgaacagctc tgtgggcacc tccaccgctg tctccccctc
     6721 cgggatctca agctgcatca gcaggtcgtt cgcgaagatc ttccagccct ggacgaggta
     6781 ggtgtcccgg tctgtggcgt acagggtcgg gcagtcgccg accgtggagt tcttaccaag
     6841 gaaccgtagc ttcatggtgg ttctcctgtc tgctgccttg cttgggattg cgcgacatga
     6901 cgatggtcga tgggctgttg tgggccgtca atcggattgc tgcaaactcg cgcaatctgc
     6961 ttgggacttg ggtgacggcc gctctacgtt cgtctccgaa cccgagcaac cgaggcagcc
     7021 gccgcacgtt gcggtaccga ggggagatgc gtggtgacca ccgtgacgga cagacgcaag
     7081 gctccagccg tcgacaacca gcccatcgac acggagctga tcgcggacag caccgacgcc
     7141 gccctgagga tgaagctggg cacctccacc cgagaaagca tcgacatcag gaccacggcc
     7201 gtcatcgagc agctgaaccg gcttctcggc atggacctgg gcgcggacga ggaccccgac
     7261 atcaggcatc tggtcagacg ggcgaacaag ctgctggatc tgtcagagcg tcctacgaag
     7321 gagacaccgg ccttcagcgc cttcttctac atgcgcgacg tcgccagtct cacccgccga
     7381 ctgctgtggg tctgcccgga ggcaggcggc catgcgccct gatcaccccg tgctccttca
     7441 tgtctctccc acgccggcac gcgccgtctg cgggcctgag tccgggttct ggtgcgagtg
     7501 gcgtcatacg gatgggcggc gcatcagctg tgctgcacag ccgaccgccg cttcggctgt
     7561 ccgatgggca cgcattcaag tccgcgtcat cgcctcggcc gccgagccgg ccttcatcga
     7621 ccttctcgtg gaccgacgtg cccagagctg gcgggacgcc gtctcagctc ttcaacaagg
     7681 tgtggatttc acgctgccgc tcgcagcggg gtcgtgctcc ttcgtgtggc atgcgcgccc
     7741 cgtcgccttt ctgcccctcg tcggcggtaa cccgatgccc catctcccgg gaggaggccc
     7801 gccatgggag tgaggccagg agagttgtgg agccgtttcg actggcgacc ggcaactgct
     7861 tcaggtgcga gcagacgaac gtccccgtgg ccgaggtcgg cgagatcgcg atggcaggca
     7921 cggcttttcc cctctgcgcc tgccagcgat gcgtcttcag gctcgaacag ctccactgga
     7981 cgatgagcga gcgcgccgcc cgcctgcgga atgccccggc tcccggacag cccactcccc
     8041 tcggccagtg gcccaccaaa gcgccactca acagaccgcc cgcccacgtc gcgtaggaga
     8101 acggccgcgt cctgggcggg ccttcaaccc cgctcccgct gttcgagctg gaggtatccc
     8161 cgacctcaga aggacaggtc acagcgggag cgggtcgcac cgccacaaga agagagagcc
     8221 gccttggcaa ccgaggaacc agacgacgac acgttgttcg acctgatcgg cgccgtcggc
     8281 gccggaatca atgccagtaa ggacgagggc cttccccttg acgtgcgcga actcgccgct
     8341 gacctggccg acaacaccgc ggacaggctg gcccagttca agaagacgac gtagtgccga
     8401 gaaggagaat gcttgtgaat gacactcccg ccccaacgtc cgagaagcac aacgcccccg
     8461 catccgaaca gcagatgcgt ggtgccatgg tggagcggct gatcgaactg ggggccgcgc
     8521 gcagtggccg cgtcgtggcc gcgttccgtt cggtaccccg gcacctggcc acccccgaag
     8581 tggacatggc caagacctac gaggccgagt tcgccccggt cacgaagacg gatgcgacgg
     8641 gcgtgaacat cagctcggtg tccgccccgc gcatccaggc catgcagatc gagcaggcgg
     8701 acatccagcc ggggatgaac gtcctggaga tcggctccgg tggggtgaac gcggcctacc
     8761 tcgccgagat ggtgggcgag cggggccacg tcgtcacgat ggacatcgac cacgacgtca
     8821 cccagcgtgc gaaggacttc ctcaaggcga ccgactacga ccggatcgtc acggtgatca
     8881 cagccgacgg cgagcacggc gtgcccggcc acgcgccgta cgaccgcatc gtcgtcaccg
     8941 tgcaggccgc cgacatcccg cccgcctggg tccaccagct gaaggagggt ggtcggctcg
     9001 tggtgccgct gcggatgcgt ggcatgaccc gcacggtggc gttcgtccgc gacagggagc
     9061 ggctcgtcag tgacgggttc gagctgtgcg ggttcgtgcc gatgcagggc gtcggggaga
     9121 accgcgtgcg cctggtattg ctccacgacg tggaagggga ggagatcgcc ctccgcctgg
     9181 acggccatcc cgagccagac gccgaggccc tgcgtgtggc tctgggcatg ccccgtgtcg
     9241 aggcgtggtc gggcgtcacc gtggccggcg acgagtccgt cgagcacctg gacctgtggc
     9301 tgacgaccgc cctcgacaat ctccccttga tggctgccaa ggtcggcgca cggaagcgtg
     9361 gtctggtcgc ctccgcgtcg ccgatcggcg tccccacgct ggtggacggt gacagcttcg
     9421 cctaccgcac cgcgcgcccc accgacgaac ccgaccggta cgagctcggg gcgatcggcc
     9481 acgggccgca gggacagaag gtcgcggacc gcctggcgga ggggatccag gtctggcaca
     9541 gcgaccaccg ggcccaccgt gcgtacatcg aggtccaccc ggcaggtacg ccggacgacc
     9601 ggcttcccgc gggccgtctc gtcgaccggc cccacacgcg ggtcacgatc acctggccgt
     9661 gacgccgtcg gcggcgccac ggtcaggccg gcacagcaca tcccacccgc cttttcccgt
     9721 gaggagtacg tgatggcaca gcagaacccc acgacaacgc tgaaggccgc gaccgactac
     9781 agcaccaaca ccgggtcgga cttcgacctc aacatcgaga ccctcgcctc cgccccggtc
     9841 ataggctcac tgctgaacga caccagcgac aactgcacct ccacctgcca gtccgcctgc
     9901 accaacagca cctgcatcgg cggctgaccc caccgcgggc cgggcggaac ctgacccgcc
     9961 cggccccgcg caccgccgtg acgaagaagg aggcacagcg atgtaccacg cattcgacgc
    10021 gagcatgatc cgcacatcag tcttcccgct ggccgcgacg cttcctcctt ggcccgactt
    10081 ggatggcgaa acccccgccg acgtcgagcg ctggcgcgac tggatcgccc aggtctggtc
    10141 ggacgacacc cgggctgccg caatcgagtt cgccgcgccg ctactcgccg ccgcaatccg
    10201 cgacgtcctc gacggaaagc ggcaacggcc gcgccccgtc cggcgcaccg cggcctcgct
    10261 cgcccgctac ctgctgcgca tgcagcaccg cgccacaccg ttcgggctgt tcgccggccc
    10321 cgcccccgtg agcatcggcg gcaccgctcg ggtgaaatgg gggaaggagc accgtgcttt
    10381 cgcccgggcc gatgccgagt ggttgaacgc cgccatcacc gccctggaag gcaaccggga
    10441 ggtgctgcgg cgcctgccgg cgatggcaga tccgacctgc acggtacgag gcactcgggt
    10501 ggcagtaccg caccagtcct gcacgaatgg ccccaccgac accacgttgc gacgaacccg
    10561 agctgtggaa gcggtgctga ccttggcccg tacgccgatc atggtcggcg acctcgtggt
    10621 caaactccac ggcgactacc cggatacgcc gaccgcggtg atcgaggaca tggtgtccag
    10681 cctcgtcgcc catcgcgtcc tgctgacgag cctccacgcc cccatgacgt gcgacgacgc
    10741 gctcggacat ctcatcgcgc agctcgacgc cacgggtgcc gccgccacat caggtggggc
    10801 ggagacagcc gaggagctgc gaaagatcca ccagctcctc acgctgcacg acatcgctgc
    10861 ccagggtgag cagcaggccc tacgcgtcca ggcggctgct cggatgaaca ccctcaccga
    10921 cgccaccacc cacaccctgg tcgtcaatgt gcgccccgac tgcgacatcg tcctgccgac
    10981 agcggtcaca tgcgaggcgg agcgtgccct ggaggtcgtc tcccgcatct cgccgtaccc
    11041 gaacggctct ccggcgtggc aggactaccg cgcacggttc ctggagcgct acagcatggg
    11101 cgccatcgtc cccctgcgcg acctcaccga cccggacacc ggcctcggct tccccgtcgg
    11161 ctaccgcggc acggtcctga agcggccggt gctggccacg acccgccgcg acgaccacct
    11221 cctcgccctc gcccagtcgg cggccctcaa cgatcggcgc gaagtcgtcc tcaccgagga
    11281 ggacatcgag gccatgtcac tcggggaacc cactcaggcg cccgctcacg tcgaactgtg
    11341 cttcaccgtg ctgtccccct cactggagga cctggagcac ggccggttcg aactggtcac
    11401 cgccggtctg tccctcgcgg ccggcaccac gacgggccgt ttcctgacga tgctggacca
    11461 gtcggaccgc gagcggatga ccgccgagta cgccgccctg ccaacgctgg ccgcaggagc
    11521 cgtacgcggg caggtgtcca gcccacccct gcgcatcccg acccgcaacg tcggccgcgc
    11581 cccatccgtc gtcccgcacg tcctctcggt cagcgagcac aacccggacg ccaccctcga
    11641 cctggacgac ctcggcgtcg tcgccgactc ccgacgcctc tacctgctct ccctctccac
    11701 cggacagctc atcgagccct cggtcatgaa cgccgtggaa ctcagcagcg ccacccaccc
    11761 cctcgtccgc ttcgtcactg aactgcaccg ctcccacacc gccatcctca cccccttcgc
    11821 ctggggcgcg gcggcccggc tgccgtttct gcccgaagtc cgcgtcggcc gcaccatcct
    11881 gtccgccgcc tgctggcggc tgaacgcaca cgacctctcc ggcgacagtc gcgactggac
    11941 gttccgtttc accgactggc gcatccgcta cggcgtgccc cgcaccgtgt acgtcggcgg
    12001 caacgaccaa cggctccgcc tcgacctcga catcagcgcc caccgccaac tcctgcgcgc
    12061 cgaactgaac cgccacggaa cggtgaccct gcacgaagcg cccgacgagg cggcgttcgg
    12121 ctgggttggc cacgcccacg aaatcaccgc gtccttcgct tccgaccaac cgccttccct
    12181 cgcgccgatc aaccgcacgg caaccgtcgt ccgccacgac tccagccgcc tgcccggcgc
    12241 cggcgagtgg gcctacctga agctgtacgg caacgccgac cgggcacccg aactgctgac
    12301 cgcgcacctc ccgagccttc tccacggctg ggacgccgac gcaccgacgt ggtggttcac
    12361 ccgctacaac gaccctgaca gccacctccg gctgcgactc cgcctcccga acccgaacac
    12421 cttcggtgcg gtggcgcagc aagtcgccgc ctgggcaggt gagctgcgca cggagggcct
    12481 gctccaacgt gtccagtggg ataccgacga gccggagacc ggccgctacg gcactggccc
    12541 cgccctcacc gcagccgaac aggtcttcgc cgcagactcc gccgccgccc tcgcacagat
    12601 ggctctcccc atccccgaca gcctccggcc cgccgtcacc gccagcagct tcgtcgacat
    12661 cgccgacgcc ttccttggct ccccagcgga cggacgggca tggcttacga cgaacctcct
    12721 gaagaacgac ggcgaagcca ccacccgcga cgtactctcc gcagccgtcc acctctccgc
    12781 cccgggtccc gaccacgcgg ccctgcaagc cttgccccac ggtgagcacc tcgccacgac
    12841 gtgggccctg cgccgcaccg ccttgactgc ctaccgccag gctctcgaag cgcacggtgc
    12901 cgaccccgcc acggttctgc cgtcccttct gcacatgcac cacaaccggg ccgccggcat
    12961 cgcccccgac agcgaagcca tctgccgccg cctggcccgc gccgccgccc tttcctggac
    13021 cgcaagagaa gaaggagccc tgcggtgacc accgctccgc ccgccctgga cacggacgcc
    13081 accctccggc agtccctcgc ccgaggctcc ctcggcatcg cactgctcca cgtcgaacgc
    13141 gctcgccagg gcaccggatc ctggcagacc gcccatcagc aactcaccga catcggaccg
    13201 ctcttggacg gcaatgagac cggcctgttc ctcggcgcgc ccgcgatggc gtacgtgctg
    13261 cactggacca ccgtcgacag caaccggtac accggcgccc tgcagaccct cgaccgaatc
    13321 gtcgccgccc acatccaacg ccgactggca gcagcacacg cccgcatcga ccgcggcgag
    13381 ccgaccacct ttgccgagta cgacctcctg cgcggcctga ccggcctcgg cgccctcctc
    13441 ctacgccgcg cccccaaagg caacgagctc aagggcgtac tggagtatct ggtgcgcctg
    13501 accgagccgc tccacaccgc cgacgggcga acccgcctgg gctggtgggt gagccacagc
    13561 cccgtcaacc tcactgctcc cgcctcagac ggccacgcca acgccggcct cgcccacggc
    13621 atcaccggcc cgctcgccct cctcgcactc gccaaaatcc gcggcaccac cgtgcccggc
    13681 cacgagacgg cgatgctgcg gatctgccgc tggctggacc agatacgagt gaacgaccac
    13741 cgaggcaccc gctggccacg ctggatcacc gaaaccacac ctgtgccgcc gcacctggcc
    13801 gccccctcct ggtgctacgg cacccccggc ctggcccgcg cccaacagct cgccgccctc
    13861 gccctgaacg accccgaccg caaacgcatg gccgaacgag cactcctcta ctgcctggcc
    13921 gaccccaccc agctcgacca actcaccagc cgcggcctgt gccacggcct cggcgggctg
    13981 ctccgcgtcg tccaacgcgt cacccaggac gccgacgaac cccgagcctt cgcccaccac
    14041 ctgccacagc tcagcgaacg cttcctgacc accgaacctc caaccgagac cggcttcctc
    14101 aacggctcgg tcggcgcgac cctcgcagtc cagaacatcc aagaaggcgc cctcccaacc
    14161 agcgactggg acgcctgcct cctcctcatc tgaccccgcc accgaaaggg atcgggatga
    14221 acttgcccga ttgcagcatg ctcgagcagg ccatcctggc cgtcctcacc ggcaccccgc
    14281 tcacggaggc cgccggacga gcgcagacgt cgcccgagca tctcgccgag accaccgagc
    14341 gctaccggga cgccggccgg tcggcactcg acccccaact cagcggctgg caccaggtga
    14401 acatcgagtt caccgactac cccacggcag aacgaacctt cggcgcctac ctcctgcccg
    14461 ccttgcgcac cgggccaatc ggagcgtggt ggttcgtgcg caagtacccc tggtggcgtc
    14521 tacgcgtcca gccgggcccg ggtacacggg tggaggacgc cgtcgcacac ctcactgaag
    14581 tactcgacag ggccctgtcc tggggcgtcg ccatgcggtg gtggcccttc ctgtacgagc
    14641 cggaaaccat cgccttcggc ggcccgcacg gcatgacgct cgcccacacc ctgttccaca
    14701 ccgacagcgt cggagtcctc gactaccacc agcacctgac ccacagcacc agcgtgctcc
    14761 ccggccccaa agagacctcc ctcctcgtca ccactctgat gctgcgggcc gccgggttgg
    14821 agtggggcga acagggagac gtatgggggc aggtcgaagc acgacgccca ctgcccacag
    14881 acgtagaccc cgaccaggtc agcaccatgg tggccccggt acagcgactc ttgacgctcg
    14941 acgccggctc cgcactcacc gacggcccac tcgcgccgct cgggaactgg gtgaccggcg
    15001 tggagcgctc cggtcaagcc ctcgtagacg cggcacgcgc gggcacgctt cagctcggcc
    15061 tgcgcggcat cctggcccgg cacatcctct tccactggaa tcggatgggc ttcaccaccc
    15121 gccaacaggc catctactcc agagcagcca gggagacgat tctcggtggc cgggagtctc
    15181 cctggccgcg gccgttcacc tcactcagcg acaacaggga ggccccgttg ttccacaggc
    15241 cgagataatc gcggtgcacc gcgaggatgc tgtgctgcac cgcgaacggc tcgagggacg
    15301 gctgaggcgc gtggtcgtca cgaacacggc cgggtcggcc gcgaagtgca ctcggcgaag
    15361 atcgggccct gccgccaggg ccgcagctcc ctcgcggcgc tgaaggccac gttcattcct
    15421 cccccgcccc gggtctactc cggttccgat ggcctcggcg agcgtgacca cgacggcgtc
    15481 gacctggcgt tggcggatat agacgagcgt acggttgccc agtcctttcc actcagctgc
    15541 tcgttgtccc actcgcgtcc ccgctggtgg atagacgaag gatcttgtcc caagtaacca
    15601 ctagccctgc agcgacggct gtggccaggg caacgcccac agcagatgaa gccagggcaa
    15661 acacaatgcc agcgagacag agggtgaacg cggcccctcg cagcacctgc tgccgccatg
    15721 ctttgcgctc tcggtgactg tgcaacagtc cgtcaccgga ttcgcccccg ggtgcgagat
    15781 cgtacagacg gccgctggag aggactttca ggattcgctc cacttcgagc agagtacgct
    15841 tcgcaccgtc gatccgatca agttcaaccc cgtcgcgaag ctcacgtaca agggcagcag
    15901 ctgctgagaa ccgggcgatg acctgaggca tggggttacg gccgtcggga agcgcccgct
    15961 gcacggcata cctctccagt gcgatggcga agtcctccaa agcccggacg gctgcaacgt
    16021 gcggggagtt gaagggtgtt gctgtcggag gctccttccc cgttacctcc agaggctgga
    16081 gaagagcctc gtaggccctc cgtgccgtga ccgtcacagc ctcggttgtc caccgttgca
    16141 tgccttggtt cgtgaccagt gaggcgacca cggcagtgat caacaagggc gccatcaggg
    16201 ccccgatcgc gagcgcgtcg cgccagacgt gccaggttgt gcgctcgatg gttgttgcaa
    16261 gagcgccgcc cgcggagacg gatgtcgcga cggggacgat catcttgatg gcgagcgccc
    16321 tcctggccac ctgatagagg acgtcttcgc gctgcaagta gtccagcgtt ggacggtctg
    16381 gacgggtcgc caaggagctg tcacggacct ggcgcaccag gtaagcgcgg cggcgtcttg
    16441 cgtgtgcccg cgcgtgagcc cagcagatcc gttccaagag tgttctggta cctcggcgct
    16501 gcgacgttgc cgtcatggtc agggcccata ccgacattgt ccaagcagcg aagatgaccg
    16561 ccccaagctc ggctttcgac acgttctccc cctctgaaac ttcgtggggc gcgccccatc
    16621 gcaagttacc cccaggagag gggtgttggc cgagccggag tcgggctcgt caccggcgcg
    16681 gcggcaacgt acagtcccca agtgcgctac gagcaaaggc cattgatgcc tcaacctgga
    16741 gcgttccctg atgagaaggc gctctctgct gttgtcctag gcaagctcga ccggtggttc
    16801 cacatcgagg agcagatacc agggcgctac tggaccggcg aagagacgcg catagacgca
    16861 gtactcaggc ccagagatcc gaaagggtgg cacgatgatg cccccgcgtt cggtgttgag
    16921 ttcaagaatc ccaccccgaa caccagcacc ggacaccgct acggctgggt cacccaggcc
    16981 gttggttacg cccattgcga gtggcaggga tacggaagac tcgggatctt cttgtgccca
    17041 tcgcctctgt cctggcttct gtcccgcgct gatgaagtcg cctccgcccg tcagaagagg
    17101 attggtcccg aatcgctgga gcaggagcga gtgagggttc gtgagtatgg acgactattc
    17161 ggcaaggagt actccgatgc ctacgtcgac cgtgaagcgc tgctggccca tcggcgcacc
    17221 ctcggggaat tgacctacga ggagttcacc gctcgcgccg acgggttcgt caacgcggac
    17281 gagcgccagc aggagcatga tctccgaatg gccgacgaac tgacccacct catagggcaa
    17341 ctcggcgtcg gtgagctcat gccctacgag aagatcggct gggcgctcac gcggtcaggt
    17401 atgcggctgt ggagcgagca ggacggagtg acccgtgtcc cattccagct gcggccgcgt
    17461 atcggctccc gatgaaatgc gtgagtgggt gcgtccacgg cgcatcactg tgtcaacctc
    17521 ggtcccgcaa gagcagcgct cccggcgcgg ccagcgaatg acgccgcgcc ttggacgcgg
    17581 cattcccaac tgatgcgcgc aacaaatcca ggtgccgcag gccccctaag cagcaggaac
    17641 ccgtcggccc cctgtacccg gtggtgggac cggctacagg gggccttgga tgagggcggg
    17701 tgggaaaagc ggccggggct cagacagacc atctctctgg ctgtcgggcg gcgttctccc
    17761 ccgtcacgca gccagcggcg gtgcctcctc tgcctgcgcg gggggcgcaa ggagggggaa
    17821 ggcacagtcc tctgggcgcc ggcccatccg ttgcgcaatg accgccgcga gcagcgcgac
    17881 ccccggaccg gtcaccggcg agcgttccat tcccacgtag aagatcccgt tctcgtcggg
    17941 ttcggcatcc acgcggtcga ggctggcgga cagcgcggcg cagtaccccc acaggtccgc
    18001 tcgcagcccg ctggggatgt ccgtgcggac ccagaccagg gggtgcagca ctccctggtc
    18061 gtcgtagccg atcgcgacca tagcccccac gccgtcggga agcggataga cctcctccgg
    18121 catgtcctcg gccgtgccag cgagtgcgtc ggtgatcagc gtgcgcagtg ccgcgatcga
    18181 ctcctcgtcg ctgcgccagc cgtgcagtgg cgcgtaggca gatccttcgt agagctcgcg
    18241 cacttccttg ctctgcttcg tgcggacttc gggtggatcg actgctggaa cgtcctccgg
    18301 gtcgacctcc tccaggaagg tctcggcgaa ggtcacctct tcctccgagt ccactgtgat
    18361 ggcggcccag ccatgaccga tgtgttcggc gaagagccgc cggattcggt gcttcttcgc
    18421 ctcctcggac agtccgggga ccgtgatgac gaggatccgg ccgcggaggg cgatgagcca
    18481 tgcctgatgg tcgtcgatca gctccctctc ggagaacgtc acacccagga tgtcacccag
    18541 gacctcgacc ggcagagccc acgcgtcatg cgcccgcagc ggcgatgctg cttgctctgt
    18601 caccgaggga gatgagcgcg gcgcgccggt agcaggctgt ttctcgtcag actcgggcgc
    18661 tgtccgtgac tgtgtgatcc gaattgggca ccacgatgct tcctttcgcc aggaaattga
    18721 gtaaatccag tctttgctgg gaaagtgcac ggcgccacat atagtcggaa aaggtcttct
    18781 cgtttgctct gcacctgcca gactgggagc cccgcacgcc ggaggggtcg cggcttcggc
    18841 ggctggacat actcttttgc atcagggagt cgacggctga gcccaaccgg ctgaggaggt
    18901 gcgcgtgaag agcaccggtt ctccgctgac gagcactgcc gcgcgccgcc gtcgaacact
    18961 tgcgcacctc tcgccaattt tcgaggtgca cctgaaccgg gcgaggaacc cgtcgagtgt
    19021 gcaatgggag gcgtatgact tcgtcgcctt gatccagtcg tgcgtggaca tgatcgctct
    19081 gtcctctggg ctggagggca atcttggcgc gccacgtgac gaggtgctcg ccgacatggc
    19141 ccgtgtctct gggagcatgg ccccacaccg ccctgctgag gaacacgcgc acgttgcccg
    19201 gcatctcctc gaccaccttc tccgccacgc cgagccgacc ccgtacttca atgtcgagta
    19261 cgcggatccg gattccagct ggcagccggt gccccttcag gtacgcgtgc tgtacgagac
    19321 gctggccgcc gacgggcgcg ccctgtatgt caacgccgac aacaccgccg tgactctgct
    19381 gctcatcgcg accaaccggt cgttggagga cgagcacgag gcggtgatcg cggtcatgcg
    19441 agcgcaggcc gagagcgggc gtctggatgc ggcgatcgac tcggcggagg acgccctgac
    19501 gctgtcgcga acctacgcgg cgaacgtccg gcgcatgatc gccgaggccg agcgggatgt
    19561 cacccgcgtc gactacctgc gagtcctgcg gcccgagctg gtagctgcgg ctgcgcatct
    19621 ggagcggcgc atcagcgtcg acggcacgtt gttgcggcac ctggaaaacc tacgggccga
    19681 cgcctccgag gagcaggaac ctgtggctgt gcggcagttg tccgtggccg cgtcgcggct
    19741 tggtgacgcg gtggaaaccc tggctgtgct gcagaccgat gtgatcgggg ccgctccgcg
    19801 ctggcgtgag gcccaggccg cgcaggcttt cagcgctgtg ccggtgagcg agatcgaccc
    19861 gacagcggac gtactgtcgg cgctgctggg cggcctaccg ttgccccgtg gtgctgagtt
    19921 gtctccaccg gctccacggg tgctgttgga tgtcgcggcg ctcgcggacc gacttgccgt
    19981 accgccgaag caggtgccgg agccggatgc tgcgcccatt gtggacgagc cgctcgaaga
    20041 cgctgacggg gtgtacgagc agttcccgga gcagttccat gatgtggccc atgtactgcg
    20101 ggctcatcgg atcatgcctg gcgccaaggc tcgtctgacc gacctgctgg ccgatgccga
    20161 ccggctgttc gccgccgagg ggccgtccgc cgtcgtcgac gggctggtcg ccgtcgtcgg
    20221 gggttcacgt gacaccgccc gccgcaggct gcggctgctg ctcgcgctcg acgcgatgat
    20281 gctctggcgg cccgacggct ggcccgacgc ttcggacgag tggtgggcgt tggacgacgg
    20341 gatacgaggg gtgttcgcgg acctggacgt tcccgatgtg ctcgtctgcc ggaaagagga
    20401 cgaagatgac agctcgtgac gacgctaggg atgtcggcct ccttctcagg tacggtctcg
    20461 accccgccat gtccccagcc cgccatgacc tctacagccg actgctggac cggttccaca
    20521 ccgaccctga cctgcgcacc gccttcgacg agacggccga cggcctcggc ctgcgggtgc
    20581 tgacagccga tcgctcagcg ggcctcgtgc tgatcgccga acccacgtcg ccgctggcgg
    20641 tgacggacac cagccactgg ctccgcatcc ggggaacggg tgatcgggcg gtgtacgggc
    20701 tggccctcgg cggtgcgacg gcgtggtgct acccaaccgc tcgtgcggtg cgtgagccgg
    20761 gtacgcggcg cgtcaccgcg ttggatgtcg accgcctcgt acgcgaacat gcggcgacta
    20821 tcgaaacgga agagatcacg ctcgacggcg ggctcggcga ggcatggcgc gagtacgcca
    20881 ccaaccgcaa acaggtcgct ctgacatcga gtggccgcct caagcgggac tgcacggtgc
    20941 ggatgtgcga ggacgtgttg ctgatgctcg cggctttcgg gctggtcatg gtcgatagga
    21001 cggttccgcc cccgcgcgct gagctgaagg tgtggcgttc cacggaccgc ttccgcgccc
    21061 acgtcgcgac cgccggaggc cctctcgtgt ggcagacgat catcggttcg caggcaccgg
    21121 aagaacaccg aaaggacagt cgcgatcagt ccccgcatac cgactacggc gagccgttcg
    21181 atgagagggg cgagtgatgc agacgggctg gcgcctcgag cgcacctacc tgaccggcgc
    21241 gggcttcccc gagtcacggc tggaggggct cagcatcaac tggtcggatc ccttcgagcc
    21301 gaccgggcat gccgcgctgt gggccgacaa cggcacggga aagacgacca tcacggctct
    21361 gcgtttcggg ttgtacctgc cgcacgcgcg ggacttcatc cgcggtgaat ccgaccggtc
    21421 tttggcgaag ctggtgcgct cgggcgacgt ctgtcatgtg gtcgagcagg ccacccgagt
    21481 cgtggacggc gaactccagc gcatcgtcat gggcatggtt accgactggg cagacggcgg
    21541 cactcaggac gtcgacaacc ctcgaagatt gcagcgcgac ttctacggat gggtgaccta
    21601 cgggtcaggt ccgactatcc aagacctgcc gttccgtacc agcgtcggtc gacgtgcgac
    21661 tcacgcccag tttgtggagg cagtgcgagg gatgctgccc aacggcggcg cgctcccgcc
    21721 gcatcgcccg tcggaccacc aacgggcatg gggcgactgg ctggccgccg ccggagtcga
    21781 tgtggagcag ttgcggttcc agtccgacat gaacgcctcc gaaggcggcg tcgaccacgt
    21841 gatgcgtttt cctgactccg acgcctgcgt ccggtggctc atcggcgcga caaccccgac
    21901 cacgaccgtc gagcagatcg gcaagagcat cgaggtccta cgggcgaacg ccgccgcccg
    21961 tccccgatgg tccgacgaac tcaccctgtg ggagagcctc accgaaccgt tgctccgcct
    22021 cgcgatcgcc catgaccagg tagccgttca ccgacgggcg gtggccaccg ccgaggtgaa
    22081 cgccgcggct gttgtggccg actccgaggc caccctggca gcactggatg tcgaggaggc
    22141 caatgccagc gagaagcacg aggagcacga acgcctgcgc cgggaggcgg gcgcgaccgc
    22201 gcggagggcg caggcacacc ggttgcgtat gcggctgaga gcggccgaac tcagggccac
    22261 cgtcgcagca gccctcgcgg acaagcgccg ctcggaccgc gaccggatgg tccgcgaact
    22321 ggccggctgg cgactcgtcc aggacgtact cgacgccaac acggccagaa gtcatctggc
    22381 cgggctcaag gcgcgcctgg aggctgccga aaagcacacc tcggagcttc gcgaggagga
    22441 acagcggcac ctgcacgccc tcgcgcggct cctcactgac caccgcgacc gtgccgccga
    22501 cgaccaccgt gctgcgaagg agcaacgggg acgggccgcc actgccctgg caacggccca
    22561 ggacgaacaa cggaaggccg tggcggccca cgcgacagct ggagagcagc ttcggcgcgt
    22621 cgctgaacag atcaccgagt ccgaacggat cctctccgaa gcagttacca ccggtctgct
    22681 tcgcgaaggt gccgatccgg taatggtgga agccggatgg actgagagag ccgctacggc
    22741 actgaggaac cgcgaggctg ctgaccaagc gctcaaagcc gccgacaaac aggctgatgc
    22801 ccagcagaag accatgacgg aagcccagaa cgcggtcgtc gccgcccagc acgacgtcga
    22861 gaacggagag cgtcagctcc aacaggtgaa cgacagggtc cgcgccctgg aggaggacga
    22921 acgcgtacag gacgccgtcg gcgacagcgg catcgagctg tggaccgccc gctcggcact
    22981 cacggacgca ttgagccaac gagccgagac ggccgacagg gacgccgccg aggcacgcac
    23041 tgcggtcggt gaggcccggc gtaccctcga cgcggtcggt gccgacggtc tacttccggc
    23101 atctgctctg gtcgaagaag ccgtccggcg ttgccaggac gccgatgtgc cggcctggcc
    23161 gggatggcgg tggctggcgg acacgatgtc ccctcaagcc gcccaatcct tcgcatcggc
    23221 acgtcccgac atcgcgtccg gcgtggtggt ctcccaccct gaccacttcc atcgcgccct
    23281 cgacgctatc gacgatctcg acaccgacac ggcggtctgg gtcggtgccg tccttgactc
    23341 agaggccgcc gtatcgccga gtgcgggcga ccactccgac ggaacactcg cccgagtcct
    23401 gctcccgcac cctggtacct acgaccggga ggccgcgggt gacatgatcg ccgccgccga
    23461 gaacgcgctg acctcggcga ctttgcgcct ccatgaagca ggtcagcgtg ccaccgacgc
    23521 ccgtagcgcc ctcgcggccc tgacccagtt ctggaaagac ctccctgagg acccgcgtac
    23581 cgctgtccag gagaagatcc gatccgctca ggtacggaga gaagcagctc gaagcgatga
    23641 acaaaccgca gcggacgcgc tccagaacct cacccagctc aagcaggagc accaagccgc
    23701 acgagacgcc gcgcaagaac tcatcgaccg cgcgaccgag aagcgacgac tcctcatccc
    23761 cgtgaccagt gctgcggaca ccctctccgg tgtccgcgca aagctgccgg gtctgcgtac
    23821 ggccgaggca gaacaccgcc gccgtgtcga ccagctcggc aaagagatac cggccctcac
    23881 caccgctgcc gaacaggcgc gcgaccaggt acgcgtccac gcacgccgcc gggacgacgc
    23941 agccgacgaa ctacgcagcg cagggctgtc agccaccact gacggcacca tccccaccga
    24001 tgacgcgccc accatccgag cacgcctgaa gagcgtcaca tcggccctgg aggacgcggc
    24061 ggtcgaccca gaactgcgcc agcgagccac cgacgccagg caactcgtcg cagacctgga
    24121 cgcgaaattg gacgccgaca tcgacctgcg gcatctggcc gaacggttcg ccagcaccga
    24181 tgacacacgc catcctgtcg cgctcgccac agcgacccgc caggccgagc atcgagaagc
    24241 ggaagcgcgc gaggagtacg cgaaagcatc gcaggccgca gaaaccgcca agcgggaaca
    24301 ccagaggcag gccgaagaac gcgcagaccg ctcctccccg gacatcgagg gcttcccgtc
    24361 ggccgatctg gttgccgagg ccgacgaagc cgatggcttc gccgaccaac tcgacgaact
    24421 cgcggcccag tccctactca cccagcgctc cgcggaacag ctcgcccgca acgcggagaa
    24481 cgccgcgacc gcggcccgcc aatcagccca gctcgtcgag gcaagcgtgg gcgcgctgcg
    24541 ctatctcacc gacccggtac tgaccggccg ccgcgcggac gacattgccg cactcaccac
    24601 ccggatctcg gctgtctccg agcgcgttcg cgagtcacgg aaacacctga cggacagcga
    24661 gcaagcccgg cagagggaag ccagcgcagt ccgcgcacac gccaacagcc cgcaggcacg
    24721 caaggtcgag gccgcagagg attcccgcgt catcgacctg atctcacggc tgcgcggcga
    24781 cgaacagctt cccgcagagg ccgaacgcat cgcgggagag ctcgaacagc gagctgtttc
    24841 gctgcgggac gacctggatc gacatgaccg cgacgtccac acctgcgcgg tcatgctgca
    24901 cgtgcaggca tcgcgggcac tcgaccggct tcgcgcctac cagaaccagt cccgactccc
    24961 ggacggtttg ggcgagtggt ccgaacggcg cttcgtcgtc atcgagcatg aaaaggctcc
    25021 ggccgacgaa tccgtcgcca tcgaccgcgt ggcccgcatc gtccacgctc tgctgacgcc
    25081 cggcgccggc cggtcggacg ctcagtccct tctgttcgcc gccacccgag ccctggtcga
    25141 cgcgcccttc agggtccgcc ttctcaaacc gcacatcgac ctctccctcg accgggtcga
    25201 cgtcgccgaa ctgaagaact tctctggtgg gcagcgggtt accgcggg
//
