LOCUS       NZ_CP102512            22563 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces sp. CA-210063 chromosome, complete genome.
ACCESSION   NZ_CP102512
VERSION     NZ_CP102512.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CA-210063
  ORGANISM  Streptomyces sp. CA-210063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10859970)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Jorgensen,T.S., Klitgaard,A.K.,
            Mourched,A.S., Blin,K., Oves-Costales,D., Genilloud,O., Larsen,T.O.,
            Tanner,D., Weber,T., Gotfredsen,C.H. and Charusanti,P.
  TITLE     Identification of the Biosynthetic Gene Cluster for Pyracrimycin A,
            an Antibiotic Produced by Streptomyces sp
  JOURNAL   ACS Chem Biol 17 (9), 2411-2417 (2022)
   PUBMED   36040247
REFERENCE   2  (bases 1 to 10859970)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Assembly Name                     :: M642_aaa1.6.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 55.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 11:12:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,501
            CDSs (total)                      :: 9,410
            Genes (coding)                    :: 9,051
            CDSs (with protein)               :: 9,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 141 of 359
            Pseudo Genes (incomplete)         :: 302 of 359
            Pseudo Genes (internal stop)      :: 23 of 359
            Pseudo Genes (multiple problems)  :: 101 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4243571
            Orig. end                         :: 4266134
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102512.1.
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22563
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="16"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22563
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22563
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12563](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12563
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(121..825)
                     /locus_tag="JIX56_RS18225"
                     /old_locus_tag="JIX56_18225"
     CDS             complement(121..825)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986215.1"
                     /locus_tag="JIX56_RS18225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18225"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_257550951.1"
                     /transl_table=11
                     /translation="MTIAVLGATGMVGSRVIAEAGARGHRVLALSRKPASENPNQTNQV
                     NRANQASLTSITVDANDSHAVREAFAGSASSGAADAVVLTVRTDPVDQEFLVGTTRTVL
                     DIAAQLGMRVLVVGGAGALRSPDDHDLLVADNPAYVPDELKPVAAAGVAQLRTCQAHAA
                     ADWVYLSPPALLEPGERTGSYRRGTDTLLTGPDGRSWISAEDLAAAVIDELETPGPEHL
                     ITVVHHEEHPPT"
     gene            1009..1938
                     /locus_tag="JIX56_RS18230"
                     /old_locus_tag="JIX56_18230"
     CDS             1009..1938
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986213.1"
                     /locus_tag="JIX56_RS18230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18230"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_257542025.1"
                     /transl_table=11
                     /translation="MLAMAAMNDNDDGVDLQQMRYVVAVAETRNFTRAAERCSVVQSSL
                     SHRIAGLERELGVKLFARSSRRVELTSAGTAFVAGARECLAAADRAVADAAAANGVVRG
                     RLAVGVIVTTAAVDVPELLQRYRARHPDVRVFLRSGRSDDLAAAIRNGDLDIAFLGLPE
                     GERPSGVEAIVLDHDEHVLVVPAGHRLAGASRVALQEIAEETFVDFVAGTPARAQSDQA
                     FAAAGLVRDVAYEAGVVELITRLITRGLGIALLPSAFVRPLAADHPELALVPVADGPRR
                     TEYLAWSRFNPSPATRAILDVLGVGRQA"
     misc_feature    complement(1030..1044)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            complement(1975..3159)
                     /locus_tag="JIX56_RS18235"
                     /old_locus_tag="JIX56_18235"
     CDS             complement(1975..3159)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959479.1"
                     /locus_tag="JIX56_RS18235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18235"
                     /product="M20 family metallopeptidase"
                     /protein_id="WP_257542027.1"
                     /transl_table=11
                     /translation="MTASHAAALTARAQDVSAEIIADILTLVRHETGSYDLPALAAGLD
                     VLREVAVTRLGAPDGEHRYPGGACGDTLTLTYAGTGAGHVALVGHYDTVWPTGTLAGWE
                     QPEATDEDGRARLSGPGIFDMKTGLAQGIWALKLARESGAPVPTVTFLFNGDEEIGSLS
                     SRPVIEETAKKVDATLVLEPTAHGAVKTARKGSGIFKVTATGVEAHAGLAPQDGASATL
                     ALSEFIVAAAAVAAPPRGTTINPGLISGGSAINVVAGSASAGIDIRVSSESEQHRVDAE
                     FAAIQVSDPRVRIEVDHAWNRPPMTLNAASAPLLDLAREVAHDQGRAPLPDTAVGGASD
                     ANFISALGLPVLCGMGAIGDGAHARGEYIHPDTVPAQTALVAGLLCRLTEPLPG"
     gene            complement(3219..4826)
                     /locus_tag="JIX56_RS18240"
                     /old_locus_tag="JIX56_18240"
     CDS             complement(3219..4826)
                     /GO_function="GO:0015558 - secondary active
                     p-aminobenzoyl-glutamate transmembrane transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:1902604 - p-aminobenzoyl-glutamate
                     transmembrane transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005476483.1"
                     /locus_tag="JIX56_RS18240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18240"
                     /product="AbgT family transporter"
                     /protein_id="WP_257542028.1"
                     /transl_table=11
                     /translation="MSATSAQPQPPDPTEPHPTEPRPTESQPAEPRSKALRAAFRSLAA
                     VEKVGNKLPHPFWLFWILAGVVAVLSAVLAALDVSAVHPGTDEKIKVLSLLSGDGITMA
                     VEGAVENYAAFPPLATILTVMFGIAVAERSGLFSALLRRMVARVPGRYLTFALSMTAMV
                     SHVAGDAAYVTLIPLGALVYRAAGRSPVLGCIVAYVSISAGYDASPSLTTTDVLLSSIS
                     TAAAQTIDADHVVTPVANYFFGLASSVLVALVITLVVDKVLARRPDLEPDEPVTALSAD
                     EREAIEVTPRQRRALRVTGLVALGYVALLAAAMIPTSSPLRGEHGGIVDSPLIGGMALV
                     LGVFFAVLGTVYGRMTGAFSAARDIVSAMADGTRSMAPILVLFFAISQFLAYFKWTNIG
                     NVLAVSGAETLRDLRLDGWTVLVGIAVLITLMNLLITSGSALWALAAPVFVPMLMLIGI
                     EPETTQAVYRVADSVTNCVTPMSPYFVMALGFVQQYRKSAGIGTLASFTLPIAAVVWVV
                     WIAFFVAWYLLGLPFGIS"
     gene            4942..5973
                     /locus_tag="JIX56_RS18245"
                     /old_locus_tag="JIX56_18245"
     CDS             4942..5973
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959150.1"
                     /locus_tag="JIX56_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18245"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_257542030.1"
                     /transl_table=11
                     /translation="MTRPLLDELDRRLIGALHLAPRATWDDIGGILSADASTLKRRYDR
                     LHEARMVRVIGQADWGMHSTAMPVHVFLDITGETPLAVLDRLRDLPHLQLLAQVSGDYP
                     LYAVVHAPSEAATSEAVDRMFSVPGVRRVNSLPALSTLRRGITWDPQFLTDTERAELLK
                     LTGGRPEGTATATATPPAKPLSEAERTVVAQLIRDGRASSASIGRAAGLATSTAHRVVR
                     RVLDEGWVRPRLEVVSQWLGFQTPFILRLRVAPGETPDVMRRIDRLPQTRLAAHVASDM
                     SVLATGLVTDRSALSSFIDHELAEIPGIVTAGVDVMLAEPRRYWLDRDLTSGLGEFHAP
                     ALL"
     gene            6106..6996
                     /gene="bla"
                     /locus_tag="JIX56_RS18250"
                     /old_locus_tag="JIX56_18250"
     CDS             6106..6996
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) Exo"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357442.1"
                     /locus_tag="JIX56_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18250"
                     /product="class A beta-lactamase"
                     /protein_id="WP_257550952.1"
                     /transl_table=11
                     /translation="MLALGAVGAGAAFAAAVPGAAYASAPGDAGLSRRLGELEREYSAR
                     LGIFAHDTATGRTVAYRADERFPICSVFKTLAAGAVLRDLDRDGEYLARRIHYTKEYVT
                     AAGYAPITGTDANVAAGMTVGELCAATVSHSDNGAANLLLRELGGPAAITRFSRSLGDR
                     TTRLDRWEPELNTAEPWRTTDTTSPRAIGKTYARLVLGRALPDRDRELLTDWLIANSTN
                     VQRFRAGLPADWTLADKTGGGSAYGVANDVGIVWPPGRPPLVLSVLSTKYDPAGPTDNP
                     LVARAAGLVAGELTG"
     misc_feature    7226..7241
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 20.59"
                     /tool="antismash"
     misc_feature    7227..7240
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    7236..7247
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            7264..7950
                     /locus_tag="JIX56_RS18255"
                     /old_locus_tag="JIX56_18255"
     CDS             7264..7950
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_18255"
                     /product="hypothetical protein"
                     /protein_id="WP_257542032.1"
                     /transl_table=11
                     /translation="MLTSTTGRLTTAAVATVAGLAVLAPAAQAVEQAPAKPAVKLTVAG
                     YTKYLKAQKTPAAKQTLKKFQGLSKGQQTVFVKDLQDRRIYKALLGKVAAPVGKPVSII
                     DPYNKEVRFVTKASSIVAKDKSRTTTVSFTVTQEIFRIPVTSETLTISYPTVGKGPKRA
                     RASATVTNVNAAIKIKNDRVSVKGFGATASWAAIPQVKSFGKPAYKAQTVLGAKSSYRA
                     TLKNVG"
     gene            8090..9301
                     /locus_tag="JIX56_RS18260"
                     /old_locus_tag="JIX56_18260"
     CDS             8090..9301
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (42-394). E-value:
                     9.5e-61. Score: 197.8. Matches aSDomain:
                     nrpspksdomains_JIX56_RS18260_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322846.1"
                     /locus_tag="JIX56_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18260"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_257542034.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.3e-58, bitscore:
                     198.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 3.2e-08, bitscore:
                     32.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.6e-06,
                     bitscore: 25.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNVSGRTDTSGMRISRRAQAVAPFYAMEFAKQAASLAAQGHDVV
                     RLSLGEPDFGAPPAVLEAMREVMDGRPMTYTAALGLPALRQAIAGFYGDQHGVDVDPGR
                     IVVTAGASAALVLATAALVDPGDEVLIGDPSYPCNRQIVESFGAGVTLVPTTAESRFQL
                     DAASVRSHWTDHTRGVMVATPSNPTGTSVPADELAAICDLARERDAWRLVDEIYLDLGD
                     HDERGRPPRSALSLDPGAVVINSFSKYFGMTGWRLGWCVVPEPLVPALERLAQNYFLCA
                     SAPAQHAALACFTPESLAVCEARRVEFGERRALVLDGLARIGLPVPVPPDGAFYVYFDV
                     GGTGLTSWQFCERALREAHVALTPGKDFGTHTAGTHVRLSYAASADELREGIARLGKFM
                     ATLR"
     aSDomain        8216..9271
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIX56_RS18260_Aminotran_1_2.1"
                     /evalue="9.50E-61"
                     /label="JIX56_RS18260_Aminotran_1_2.1"
                     /locus_tag="JIX56_RS18260"
                     /protein_end="394"
                     /protein_start="42"
                     /score="197.8"
                     /tool="antismash"
                     /translation="DVVRLSLGEPDFGAPPAVLEAMREVMDGRPMTYTAALGLPALRQA
                     IAGFYGDQHGVDVDPGRIVVTAGASAALVLATAALVDPGDEVLIGDPSYPCNRQIVESF
                     GAGVTLVPTTAESRFQLDAASVRSHWTDHTRGVMVATPSNPTGTSVPADELAAICDLAR
                     ERDAWRLVDEIYLDLGDHDERGRPPRSALSLDPGAVVINSFSKYFGMTGWRLGWCVVPE
                     PLVPALERLAQNYFLCASAPAQHAALACFTPESLAVCEARRVEFGERRALVLDGLARIG
                     LPVPVPPDGAFYVYFDVGGTGLTSWQFCERALREAHVALTPGKDFGTHTAGTHVRLSYA
                     ASADELREGIAR"
     misc_feature    9557..9572
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.83"
                     /tool="antismash"
     gene            9676..9810
                     /locus_tag="JIX56_RS18265"
                     /old_locus_tag="JIX56_18265"
     CDS             9676..9810
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="JIX56_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18265"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_257542036.1"
                     /transl_table=11
                     /translation="MEQPQMDEKPVYQPPAVAEVAEFSELTTGCGFDFFEMPAQHNIC"
     misc_feature    complement(9988..10002)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            10001..11857
                     /locus_tag="JIX56_RS18270"
                     /old_locus_tag="JIX56_18270"
     CDS             10001..11857
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="JIX56_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18270"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_257542038.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.3e-38, bitscore:
                     131.9, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPESTTPGSGWFAVLPDCDAARAAAAVLGAEATRIVEHASGRPWL
                     VGRWAEDEAVVATVGDARVAVVGLSPLTESRLAALVREDDALGSLDRLATGPVGGCHLL
                     ASQSGRLRSQGTASGLRQLFSARLAGVVVACDRADVLATAVDAGIDERLVALRLMDPLI
                     PHPLAERPLWRGVSAVPAGTALLTDAAGNARTRRWWQAPEPELPLAEGAERLAEALADA
                     VAVRTAGGGVISSDLSGGLDSTSLCFLAARGPARLLALTLTGADPANDDLSWARRAAAH
                     LSDTDHQVLPMDELPPHYTGVLRAGEGVDEPFTGVRVRAPFAETARRLAGMGSRLHLSG
                     EGADQILSARPPYLHTTFRTRPRTALTHLRATLSAQRWHLLPTLRALADRRSYGRWLAD
                     TARDLSPVLALDGTPALGWQMLRPQLPPWASPDAAAAVRELLWQTALEAEPLAPTRGQH
                     EVLWSVRNGTRLARQLTRVTSEAGLPTHYPFYDDRVVEAALAVRLHERTTPFAYKPLLV
                     RAMREAVPAELLARRTKGEYSAEMQSGLRTRRADLADLLDRPLLATLGLVDADALRRAC
                     LSMFPPRLSPVTLEATLAVETWLRAHAGPASATPAMGSEAAA"
     gene            11854..12144
                     /locus_tag="JIX56_RS18275"
                     /old_locus_tag="JIX56_18275"
     CDS             11854..12144
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009308634.1"
                     /locus_tag="JIX56_RS18275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18275"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_257542039.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 6.9e-10,
                     bitscore: 38.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.6e-26,
                     bitscore: 89.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-15, bitscore: 55.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAAGKRNRNAAGTRLRRHVSVSDVEDGMVLLDERKGRYFKVNAS
                     GALILRALLDGAPPADAVRALVERYEVSEERAAADVDALTAELAGNGLVVS"
     aSDomain        11893..12060
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JIX56_RS18275_Lasso_Fused_RRE.1"
                     /evalue="2.10E-12"
                     /identifier="RREFam003.1"
                     /label="JIX56_RS18275"
                     /locus_tag="JIX56_RS18275"
                     /protein_end="69"
                     /protein_start="13"
                     /score="38.0"
                     /tool="antismash"
                     /translation="TRLRRHVSVSDVEDGMVLLDERKGRYFKVNASGALILRALLDGAP
                     PADAVRALVER"
     aSDomain        11896..12138
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JIX56_RS18275_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.00E-28"
                     /identifier="RREFam002.1"
                     /label="JIX56_RS18275"
                     /locus_tag="JIX56_RS18275"
                     /protein_end="95"
                     /protein_start="14"
                     /score="89.3"
                     /tool="antismash"
                     /translation="RLRRHVSVSDVEDGMVLLDERKGRYFKVNASGALILRALLDGAPP
                     ADAVRALVERYEVSEERAAADVDALTAELAGNGLVV"
     gene            12141..12563
                     /locus_tag="JIX56_RS18280"
                     /old_locus_tag="JIX56_18280"
     CDS             12141..12563
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009308635.1"
                     /locus_tag="JIX56_RS18280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18280"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_257542041.1"
                     /sec_met_domain="PF13471 (E-value: 6.5e-23, bitscore: 80.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPSVFQERRRLPMRRRPLPLLAVGAAHLIGRLSPLRIRQILTA
                     CSLGGRPATYAEAARARADVVAVSVRCAGQGCLPRSIATALLCRARGTWPTWRTGMRTV
                     PMVAHAWVEAEGRPVDDLPLTPGIPPLITVAPRARS"
     gene            12579..13505
                     /locus_tag="JIX56_RS18285"
                     /old_locus_tag="JIX56_18285"
     CDS             12579..13505
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385816.1"
                     /locus_tag="JIX56_RS18285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18285"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_257542043.1"
                     /transl_table=11
                     /translation="MPGDDIAVHAEELSKLYGTREAVVGLDLTVPAGRIFGFLGPNGAG
                     KSTTIGMLCTLLRPTLGDAWVAGAHVVREAARVRRRIGVVFQEQTLDQDLTVMESMRLQ
                     AELYGLPGAAARAAGTALLGLVGLADRAGHVVRTLSGGTRRRLEIARALVHGPRVLFLD
                     EPTAGLDPQTRAAVREYLRLLCREHGITVFLTTHHLEEAEHCDRIAIIDHGELVTEGTP
                     RELKAVIGADLVTLRTDDDERVAEAVRRSFGLPTETGPDGVRLRAADGAALVPRLCAQL
                     TVPVRSVTVTSPTLDDVFLHHTGRTIR"
     gene            13531..14424
                     /locus_tag="JIX56_RS18290"
                     /old_locus_tag="JIX56_18290"
     CDS             13531..14424
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123205.1"
                     /locus_tag="JIX56_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18290"
                     /product="ABC transporter permease"
                     /protein_id="WP_257542045.1"
                     /transl_table=11
                     /translation="MPLSSATTSDSLSPPAPDATGGRGAPDRRAGPFVADLRTLRILWR
                     REMTRFLRNRARLVMGLAAPLLFLFVLGNGIGSAGGDLGHYQAFLFPGTLLMVVQGPAV
                     AVGTVLMWDRQSGFLRQMLVAPVRRGAILAGICLGGATTGALYALPVLALAGPMGLPYH
                     PRLLLVLGEVALLSFALTALGVSAAVCIRRPETFQIVSGLAMAPAMLLSGALFPVGGLP
                     SWLGAAVLANPLSYGVDALRRTMPDPDPTTAAPAWFHAGPEWWGWTPPVLLELALVVLP
                     SLLLLLLAGRRFARID"
     misc_feature    complement(14477..14497)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.52"
                     /tool="antismash"
     misc_feature    complement(14497..14515)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.02"
                     /tool="antismash"
     gene            14651..15613
                     /locus_tag="JIX56_RS18295"
                     /old_locus_tag="JIX56_18295"
     CDS             14651..15613
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS18295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_18295"
                     /product="hypothetical protein"
                     /protein_id="WP_257542047.1"
                     /transl_table=11
                     /translation="MSYPTPPQPPGSAGGYGQQPGPYGQQPQQYGQPPQLGSWPQDRPQ
                     QYPGQAPYPGQAPHPAPVPTPPPAKGGAARGCLAGALGFLGLLGMLGGGLLVGHAYSNA
                     SQDIPNRDGYGPTMWRNEPADKLFPDYLAPRVSATTTKADSARATWHRVGISEDTDCAT
                     GLNKATSAAVAKLDCEAVLRATYVDPTGNTVGTVALIVLPAGESAKTEMTTFFEADEEK
                     LDPEVGVKALAVPGTIAAKWSDARSNGGAGIVVPEGSLPYVLVASTGAVDGRKAGHLPG
                     EFGSHNWDAGDDRAPWRGAAKALCDDLNYHLGDLILETS"
     gene            15610..16812
                     /locus_tag="JIX56_RS18300"
                     /old_locus_tag="JIX56_18300"
     CDS             15610..16812
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014176481.1"
                     /locus_tag="JIX56_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18300"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_257542049.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 7.3e-40, bitscore:
                     136.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTGTGMSRGAGIGMGRTVRRAGAATAAAALLLGTAAAGAASAAE
                     TTPQSWEYQALKLGAAQRLAQGEGVTVAVLDTGVEADHPALKGKVTTGPDYIGDGSDSD
                     EADNEGRHGTAMASDVLKVAPKAKILSIRVTDGSGEPGYSKGGNPVAQGINYAIEHGAD
                     VISMSIGDQLLGSSYDEDEADALGRAALAGVPVLASAGNNGDLFNDAQYPAGYPGVIAV
                     AALQPGGTRAAFSTVRTYNAVAAPGVDIMSASNTGGYATIDGTSPATALASGVVALMLS
                     HNDKLTPAQVRTILTTTAGHAAQGHSPLDGYGVIDAPAAIEAAEKPPADRTEPVAYKGE
                     EHLGTPDGTSKTKHPELDTEMVTIGGGAAAVGLLMAVGAVLIGRAGRRRATPAGGRAVT
                     R"
     gene            16830..17225
                     /locus_tag="JIX56_RS18305"
                     /old_locus_tag="JIX56_18305"
     CDS             16830..17225
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134308.1"
                     /locus_tag="JIX56_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18305"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257542050.1"
                     /transl_table=11
                     /translation="MQSYTIGQAARLLGVSPDTARRWADAGRVATRRDESGRRLIDGKD
                     LAAFSVELASDTADEADVPYTSARNAFAGIVTAVKLGDVAAQVEIQAGPHRLVSLLTRE
                     AVEELGLEVGMEATARVKSTNVHIDRT"
     misc_feature    17386..17400
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.1"
                     /tool="antismash"
     gene            17388..18182
                     /gene="modA"
                     /locus_tag="JIX56_RS18310"
                     /old_locus_tag="JIX56_18310"
     CDS             17388..18182
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015412 - ABC-type molybdate transporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0030973 - molybdate ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015689 - molybdate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="modA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019981416.1"
                     /locus_tag="JIX56_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18310"
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_257542052.1"
                     /transl_table=11
                     /translation="MIRSVRLVAGVGAAALLVTLSACSSSDEASPAASGSSDELSGTVT
                     VFAAASLKESFTTLGKRFEEEHPGTKVTFNFGGSDSLAASITGGAPADVFASASPKTMA
                     IVTDAGDASGAPATFVRNQLEIVTLPGNPDRIASLKDLTESGLKVVLCDKEVPCGAATQ
                     KALEASGLKLTPVSYEQDVKAALTKVELKEADAAVVYKTDVQAAGDKVEGVDFPESADA
                     VNDYPIALLKDAPNADAAEAFIELVRSAEGRQVLTGAGFLEP"
     gene            18179..19042
                     /gene="modB"
                     /locus_tag="JIX56_RS18315"
                     /old_locus_tag="JIX56_18315"
     CDS             18179..19042
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015412 - ABC-type molybdate transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015689 - molybdate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="modB"
                     /gene_functions="transport (smcogs) SMCOG1214:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474069.1"
                     /locus_tag="JIX56_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18315"
                     /product="molybdate ABC transporter permease subunit"
                     /protein_id="WP_257542054.1"
                     /transl_table=11
                     /translation="MSRPSGSPDASGTVVAGGARRVRRVRRLRGSVPVPLLLPALIGVA
                     FLVLPLVALLVRTPWSSLPEQLTSAEVWEALRLSLVCATLATVVSLVLGVPLAWVLARV
                     EFPGRGLVRALVTLPLVLPPVVGGVALLMALGRNGVVGRLLDDWFGLTLPFTTTGVVIA
                     EAFVAMPFLVISVEGTLRAADPRYEEAATTLGASRFTAFRRVTLPLIAPGVAAGAVLAW
                     ARALGEFGATITFAGNFPGRTQTMPLAVYLALQSDPAAAISLSLVLLAVSVAVLAGLRD
                     RWMTAS"
     gene            19143..20417
                     /locus_tag="JIX56_RS18320"
                     /old_locus_tag="JIX56_18320"
     CDS             19143..20417
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010041362.1"
                     /locus_tag="JIX56_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18320"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_257542056.1"
                     /transl_table=11
                     /translation="MSETPAAVDPALAANGADRSEGLDAHLVVQRGDFRLDVSLTAAPG
                     DVVALLGPNGAGKTTALRALAGLTPLTGGHLRLEGAALERTAPESRPVGVVFQDYLLFP
                     HLTALDNIAFGPRCQGATKAEARAQAAEWLDRMGLAEYAGTKPRRLSGGQAQRVALARA
                     LATRPRLLLLDEPLAALDARTRLDVRAQLRRHLAEFEAVAVLVTHDPLDAMVLADRLVV
                     VEHGRVVQEGTPRDIARHPRTDYIAHLVGLNLYRGQAEGHVVRLDTEGMATTGAVGDTG
                     GRGPAGAPTKNAGRPADTPAKTTGRPAGAPTKTTGRPADTPAKTTDRPAITTTEDLTGP
                     VFVAFPPSAVTLHRDRPTGSSARNLWRCEVAGLEVHGDQIRADLTGELPLTADLTTVAA
                     AELGLHPGTPVWVTVKATQTHAYPA"
     gene            complement(<20454..20834)
                     /locus_tag="JIX56_RS18325"
                     /old_locus_tag="JIX56_18325"
                     /pseudo=""
     CDS             complement(<20454..20834)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005476488.1"
                     /locus_tag="JIX56_RS18325"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18325"
                     /product="aminoglycoside phosphotransferase family protein"
                     /pseudo=""
                     /sec_met_domain="APH (E-value: 2.2e-05, bitscore: 23.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSRADFIAEAYGLGAGAWRMEPVARGALGQIWRLSGGGGGGVSW
                     AVKELLFECDEEQVGREAALRNAAEALGISAPRLFADREGAYVSRLPGSSGGSYVKLYD
                     WVDGDEADPADPEILGWCGRTLA"
     gene            complement(20928..22445)
                     /locus_tag="JIX56_RS18330"
                     /old_locus_tag="JIX56_18330"
     CDS             complement(20928..22445)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133242.1"
                     /locus_tag="JIX56_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_18330"
                     /product="MFS transporter"
                     /protein_id="WP_257542058.1"
                     /transl_table=11
                     /translation="MTYDGCARTVHEERKGLDDMSVTDSEAAGTAPRRRRDTAPGPAAA
                     TALTPRLRLTLVVLLAAQFMLAVDFSILNVALPVIGEGLGFSLAGLQWIGTAFALCAAG
                     FTLLFGRVADLFGRRRLFLGGLVVLAVASLVGGLARDPEVLIAARVFQGLATAAVTPAG
                     LSLLTTSFPEGPLREKALGLNGALMSAGFTTGAILGGLLTDLLSWRWAFFVNVPVALAV
                     LVIAPTVIKESRIQERPRLDVPGAVSVTLGLLAVVLGLTRAGEHGWGSPAALLSLAVGA
                     VLLVVFHAVERRAAAPLVPVGVLGKRSVAWGNVAGLIAFLTETSLVFLLTLYLQEVLGF
                     SPLAAGLSFGVLGVGTVVGGTLAPRVIGRLGTRRTLIVGGVVQTVFTAALLGLGDDRSW
                     MWLLLVATFAGGVGNMLVIVGFMVTATSGLADHEQGLATGLATMTQQIGITMGTPIMSA
                     VATAALGGSGAAAVLGGLKVAIALNAAVVLLGTLTSALFLREGRVRE"
ORIGIN
        1 tgcatgaggc ggggcatcag ccgtactgcc tggtctggcc ctgacccggg gactcatggt
       61 tggcgggcgg agctttcggg ctccgccctc gtcatgggtg ggtcggtgag ggtcttgggc
      121 tcacgtcggc ggatgttcct cgtggtggac gaccgtgatg aggtgttcgg ggccaggggt
      181 ctccagttcg tcgatgacgg cggcggccag gtcctcggcg ctgatccagg atcggccgtc
      241 ggggccggtg agcaaggtgt cggtgccgcg ccggtagctg ccggtgcgtt caccgggctc
      301 cagcagggcc ggcgggctca ggtagaccca gtcggcagcg gcatgagcct ggcaggtccg
      361 caactgggcg accccggcgg cggctacggg cttcaactcg tccggcacat aggcggggtt
      421 gtcggcgacc agcagatcgt ggtcgtcggg gctgcgcaac gccccggctc cgccgaccac
      481 gaggacgcgc attccgagct gtgcggcgat gtccagcacc gtacgggtgg tgccgaccag
      541 gaactcctgg tcgaccggat cggtccgcac ggtcaggacg acggcgtccg cggcgccgct
      601 cgaggcggag cccgcaaacg cctcgcgtac ggcgtgcgag tcattcgcgt cgaccgtgat
      661 cgacgtcagg cttgcctggt tcgcccggtt cacctggttc gtctggttcg ggttctcgct
      721 cgcgggcttc cgagacaggg cgagcacccg gtgtccgcgt gcgccggcct cggcgatgac
      781 ccggctgccg accatccctg tggcgccgag cacggcgatc gtcatggctg ccttcacctt
      841 caccttcacc ttcacctgct cctgctcctg ctcctgctcc tgctcctgct cctggcccgg
      901 taaccgctcg gtcgaggtcc gcgggttctg cgcgccacga gcactctgcg ggctctgtgt
      961 gttctgcatg tgatgaagtc tcagtaccac tcaccatgaa tccaaagcat gcttgccatg
     1021 gcagccatga acgacaacga tgatggtgtg gatctccagc agatgcgcta cgtcgtcgcc
     1081 gtcgccgaaa cccgcaactt cacccgcgcc gccgagcgct gctccgtggt gcagtcgtcg
     1141 ctcagtcacc ggatcgccgg gctggaacgg gagctcgggg tcaagctgtt cgcccggtcc
     1201 agccgccgcg tcgagctgac cagtgccgga acggcgttcg tcgccggcgc gcgcgagtgt
     1261 ctggccgctg ccgaccgcgc ggtcgccgac gccgccgccg cgaacggcgt ggtacgcggc
     1321 cgactcgccg tcggcgtgat cgtgaccacg gctgccgtcg acgtacccga gttgctgcag
     1381 cgataccgtg cccggcaccc ggacgtccgc gtcttcctcc gttccggacg cagcgacgac
     1441 ctggccgcgg cgatccggaa cggcgacctg gacatcgctt tcctgggcct gccggagggc
     1501 gaacggccgt ccggcgtgga agccatcgtc ctcgaccatg acgagcacgt actggtggtg
     1561 ccggccggac accggctggc cggcgcttcc cgcgtcgcgc tccaggagat cgccgaggag
     1621 acgttcgtgg acttcgtggc cgggacacct gcccgggccc agtccgacca ggcgttcgct
     1681 gccgcgggcc tggtccgcga cgtcgcgtac gaggccggcg tcgtcgagct gatcacccgg
     1741 ctgatcacgc gcgggctcgg catcgcgcta ctgccgtcgg cgttcgtccg accgctggcc
     1801 gccgaccatc ccgaactcgc gctggtcccg gtggccgacg ggccgcgtcg caccgagtat
     1861 ctggcgtgga gccgcttcaa ccccagcccg gccacccgag cgatactcga cgtcctcggg
     1921 gtcgggcgac aggcgtagcc cgggcagggg tggtgatggc ccatccgccg gcgttcagcc
     1981 cggtagcggc tccgtcaggc ggcacagcag ccccgcgacc agggccgtct gggccgggac
     2041 cgtgtcgggg tggatgtact cgccccgggc gtgggcgccg tcgccgatgg cgcccatgcc
     2101 gcagaggacg gggaggccga gggcggagat gaagttggcg tcgctggcgc cgccgacggc
     2161 ggtgtcgggg aggggggcgc ggccctggtc gtgggcgact tcgcgggcga ggtcgaggag
     2221 gggcgcggag gcggcgttga gggtcatcgg ggggcggttc caggcgtggt cgacctcgat
     2281 gcgtacgcgg gggtcgctga cctggatcgc ggcgaactcg gcgtccacac ggtgctgttc
     2341 gctctcgctg ctgacccgga tgtcgatgcc cgcgctggcc gaccctgcga cgacgttgat
     2401 ggccgaaccg ccgctgatga ggccggggtt gatcgtcgta ccccgtgggg gcgcggccac
     2461 ggccgcggcg gcgacgatga attcggacag tgccagggtc gcgctcgccc cgtcctgcgg
     2521 tgcgagcccg gcgtgtgcct ccacaccggt ggccgtgacc ttgaagattc cggagccctt
     2581 gcgggcggtc ttgaccgcgc cgtgggccgt gggctccagg accagcgtcg cgtccacctt
     2641 cttggcggtc tcctcgatca ccgggcggga cgagagggag ccgatctcct cgtcgccgtt
     2701 gaagaggaag gtgacggtgg ggaccggggc gccgctctcc ctggccagct tcagggccca
     2761 gatcccttgc gccaggccgg tcttcatgtc gaagatgccc ggcccgctga gcctcgcccg
     2821 tccgtcctcg tccgtcgcct ccggctgctc ccagccggcc agcgtgcccg tcggccacac
     2881 cgtgtcgtag tggccgacca gcgcgacgtg tccggcgccc gtgcccgcgt aggtgagcgt
     2941 cagggtgtcc ccgcacgccc cgccggggta ccggtgttca ccgtcgggcg caccgaggcg
     3001 ggtgaccgcc acctcccgca ggacgtccag gcccgccgcg agcgcgggca ggtcgtagct
     3061 gccggtctcg tggcgtacga gggtcaggat gtcggcgatg atctccgccg agacgtcctg
     3121 ggcgcgggcg gtgagggcgg cggcatgcga tgcggtcatg gtctgccttc tcgtgcgacg
     3181 gcgtttgtgt gcgggggggt gtctctgggg gttgcgggtc agctgatgcc gaacgggagg
     3241 cccagcaggt accaggccac gaagaacgcg atccagacga cccagacgac ggcggcgatc
     3301 gggagggtga aggaggcgag ggtgccgatg ccggcggact tccggtactg ctggacgaag
     3361 cccagcgcca tcacgaagta cgggctcatc ggggtgacgc agttggtgac ggagtcggcg
     3421 acgcggtaga cggcctgggt ggtctcgggc tcgatgccga tgagcatcag catggggacg
     3481 aagacgggcg cggccagggc ccagagcgcg gaaccgctgg tgatgaggag gttcatcagg
     3541 gtgatcagta cggcgatgcc gaccagcacg gtccagccgt cgagcctcag gtcgcgcagc
     3601 gtctccgcgc ccgagacggc gaggacgttg ccgatgttcg tccacttgaa gtaggcgagg
     3661 aactgggaga tcgcgaagaa caggacgagg atcggcgcca tcgaccgggt gccgtcggcc
     3721 atcgcggaga cgatgtcgcg ggcggcggag aaggcgccgg tcatacggcc gtagacggtg
     3781 ccgaggacgg cgaagaacac gccgaggacg agtgccatcc cgccgatgag cggggagtcg
     3841 acgatgccgc cgtgctcgcc gcgcagcggt gaggacgtgg ggatcatggc ggcggccagc
     3901 agggcgacat agccgagggc gaccagcccg gtcacgcgca gggcgcggcg ctggcgcggg
     3961 gtcacctcga tcgcctctcg ctcgtcggcg ctcagcgcgg tgacgggctc gtcgggctcc
     4021 aggtccgggc ggcgggcgag gaccttgtcg acgacgaggg tgatgaccag ggcgacgagg
     4081 accgacgagg cgagcccgaa gaagtagttg gcgaccgggg tgacgacatg gtcggcgtcg
     4141 atggtctgtg cggcggcggt ggagatcgac gacagcagga cgtcggtcgt ggtgagggac
     4201 ggcgaggcgt cgtagccggc cgagatggag acgtacgcga cgatgcagcc gaggaccggg
     4261 ctgcggcccg ccgcgcggta gacgagcgcg ccgagcggga tgagggtgac gtacgcggcg
     4321 tcgccggcga catggctgac catggccgtc atcgacagcg cgaaggtcag ataccggccg
     4381 gggacgcgcg cgaccatgcg gcgcaggagg gcggagaaga ggccgctgcg ctcggcgacg
     4441 gcgatgccga acatcacggt gaggatggtg gccagcggcg ggaaggccgc gtagttctcg
     4501 accgccccct cgacggccat cgtgatgccg tccccgctga gcagggacag caccttgatc
     4561 ttctcgtccg tccccgggtg cacggcgctg acgtcgagcg ccgccagcac ggcactgagg
     4621 acggcgacga cccccgcgag gatccagaac agccagaacg ggtgggggag cttgttgccg
     4681 accttctcga ccgccgccaa gctccggaac gcggcacgca gggctttcga ccggggctcg
     4741 gccggctgtg actcggtcgg gcgtggctcg gtcgggtgtg gctcggtcgg gtcgggcggc
     4801 tgtggctggg cagaggtggc actcatcggt acctcttcgt gcactggagg gatgttcctg
     4861 catacgatgg cacccacatg agagatttcc caggacgccg acgtaacatc gggattaatc
     4921 ggcggtctaa ggtggggcag catgacccgc cctctcctcg acgagctcga ccggcgcctc
     4981 atcggggcac tgcacctggc gccccgggcg acctgggacg acatcggcgg gatcctgtcc
     5041 gccgacgcca gcacgctcaa acgccgttac gaccggctgc acgaggcccg gatggtgcgg
     5101 gtgatcgggc aggcggactg gggcatgcac tccacggcca tgccggtcca cgtcttcctg
     5161 gacatcaccg gcgagacccc gctggccgtc ctcgaccggc tgcgcgacct gccccacctc
     5221 cagctcctcg cgcaggtctc cggcgactac ccgctctacg ccgtcgtgca cgccccctcc
     5281 gaggcggcga ccagcgaggc ggtcgaccgg atgttctccg tccccggcgt ccgccgcgtc
     5341 aactccctgc ccgcgctcag cacgctgcgc cggggcatca cctgggaccc gcagttcctg
     5401 accgacaccg agcgggccga gctgctgaag ctcaccgggg gccggccgga gggcaccgcg
     5461 accgcgaccg ccacgccccc cgcgaaaccc ctcagcgagg ccgaacgcac cgtcgtcgcc
     5521 cagctgatcc gggacggccg ggcctcctcc gcgagcatcg gacgggccgc gggcctggcc
     5581 acctccaccg cgcaccgcgt cgtccgccgg gtcctggacg agggctgggt caggccccgg
     5641 ctggaggtcg tgtcgcagtg gctgggcttc cagaccccgt tcatcctccg gctgcgggtc
     5701 gcccccggcg aaacccccga cgtcatgcgc cgtatcgacc ggctcccgca gacccgcctc
     5761 gccgcccacg tcgccagcga catgtccgtc ctcgccaccg gcctcgtcac cgaccgctcc
     5821 gccctctcgt ccttcatcga ccacgagctg gccgagatcc ccggcatcgt cacggccggc
     5881 gtcgacgtga tgctcgcgga gccgcgccgc tactggctgg accgcgatct gacctcgggc
     5941 ctcggggagt tccacgcacc ggcgttgctg tgagcgacct ggggcggagg gaaacctgtg
     6001 tggccacggt ggcgtcttca gaggcgagcg gagatcaaga ccaggcaggg gaaaaccttg
     6061 gaaaccacag gatcacgtcc caccccggag cgaagccgcc gcgcggtgct cgccctcggt
     6121 gccgtcggtg ccggcgcggc gttcgcggcc gccgtgccgg gggcggcgta cgcctcggct
     6181 cccggcgacg cggggctctc ccggcgactg ggtgagctgg agcgggagta ctccgcgcgg
     6241 ctggggatct tcgcccacga cacggccacg gggcgcacgg tggcgtaccg cgcggacgag
     6301 cggttcccca tctgctcggt gttcaagacg ctcgccgccg gggcggtcct acgggacctc
     6361 gaccgcgacg gcgagtacct cgcccggcgg atccactaca cgaaggagta cgtcacggcg
     6421 gcgggctacg ccccgatcac cggcacggac gcgaacgtgg ccgccggcat gaccgtcggg
     6481 gagctgtgcg ccgccaccgt ctcgcacagc gacaacgggg cggcgaacct gctgctgcgc
     6541 gagctgggcg ggccggccgc gatcacccgg ttcagccgct cgctcggcga ccgcacgacc
     6601 cggctcgacc gctgggagcc cgagctgaac acggcggaac cgtggcggac cacggacacc
     6661 accagcccgc gcgcgatcgg gaagacctac gcgcggctcg tcctcggccg ggccctgccg
     6721 gacagggacc gggaactgct gaccgactgg ctgatcgcca actcgaccaa cgtccagcgc
     6781 ttccgcgcgg gtctccccgc cgactggacc ctcgcggaca agaccggggg cggatcggcg
     6841 tacggcgtcg ccaacgacgt gggcatcgtc tggccgcccg gccgcccgcc cctcgtcctg
     6901 tccgtcctgt cgaccaagta cgaccccgcg gggcccacgg acaatccgct ggtggccagg
     6961 gcggcggggc tggtggcggg ggaactcacg ggctgagcgc tccgctggta ggacggtggc
     7021 gaagctgcgg gccggtgggg gctggtcgcg cccacgcggc ggtagccgca cattcgacac
     7081 agccccgcgc ccctcacggg gcgcggggac gatcaggcag tgcccttccg ggtgctgccc
     7141 cttcgggtgg tggccttcgg ggtggtggcc ttcggggcag tggctggaga gacaatttcg
     7201 ggcgagtgcc ggggttcgta gggtcgttga cgcaggtaaa cgcacgcgtc acggggagcc
     7261 cagatgctta cttccaccac cggtcgactc acgaccgcgg ccgtcgccac ggtcgccggt
     7321 ctcgctgttc tcgcgcccgc cgcccaggcc gtggagcagg cgccggcgaa gcccgcggtc
     7381 aagctgaccg tcgccggtta caccaagtac ctcaaggcac agaagacgcc cgcggcgaag
     7441 cagaccctca agaagttcca ggggctgagc aagggtcagc agaccgtctt cgtgaaggac
     7501 ctccaggacc gcaggatcta caaggcgctg ctcggcaagg tggcggcgcc cgtgggcaag
     7561 ccggtcagca tcatcgaccc gtacaacaag gaagtgcgct tcgtcaccaa ggcgtcctcg
     7621 atcgtcgcca aggacaagag ccgcacgacg accgtcagct tcacggtgac ccaggagatc
     7681 ttccgtatcc cggtcaccag cgagaccctg accatcagct acccgacggt cggcaagggc
     7741 ccgaagcggg cgagggccag cgccacggtc accaacgtca acgcggccat caagatcaag
     7801 aacgaccgcg tcagcgtgaa gggcttcggc gccaccgcct cctgggccgc catcccgcag
     7861 gtgaagtcct tcggcaagcc cgcgtacaag gcgcagaccg tcctcggcgc caagagcagc
     7921 taccgggcca ccctcaagaa cgtcggctga cccacaagct cggccatcgg ctgacccacc
     7981 ccgcgcgccc ctgccccggg cgcgcccgcg aggcccagga ccacctcccg tcctgggcct
     8041 cgcccctgcc gctggccccg atccccctcg gggccgcagc atgagcggca tgagcaacgt
     8101 gagcggcagg acagacacga gcggcatgcg gatctcgcgg cgggcccagg ccgtcgcccc
     8161 cttctacgcg atggagttcg ccaagcaggc cgcctcgctg gccgcccagg ggcacgacgt
     8221 cgtcagactc agcctcggcg agccggactt cggcgcaccc ccggccgtcc tggaggcgat
     8281 gcgcgaggtc atggacgggc ggccgatgac gtacacggcg gcgctcgggc tgccggccct
     8341 gcggcaggcc atcgcggggt tctacggcga ccagcacggc gtcgacgtcg atccgggccg
     8401 gatcgtcgtc acggccggcg cctcggccgc gctcgtgctg gccaccgccg cgctcgtcga
     8461 ccccggtgac gaggtcctca tcggcgaccc ctcctacccg tgcaaccggc agatcgtcga
     8521 gagcttcggc gccggggtca ccctcgtccc caccaccgcc gagtcccggt tccagctgga
     8581 cgcggcgtcg gtccgctccc actggacgga ccacacgcgc ggggtgatgg tcgccacccc
     8641 gtccaacccc acgggcacct ccgtaccggc cgacgaactg gccgcgatct gcgacctcgc
     8701 ccgcgaacgc gacgcgtggc gcctcgtcga cgagatctac ctcgacctcg gggaccacga
     8761 cgagcggggc cgcccaccgc gcagcgcgct ctcactggac cccggcgccg tcgtcatcaa
     8821 cagcttctcc aagtacttcg gcatgaccgg ctggcggctc ggctggtgcg tcgtccccga
     8881 acctctcgtc ccggccctcg aacgcctcgc ccagaactac ttcctctgcg cctccgcccc
     8941 cgcccagcac gccgccctcg cctgcttcac ccccgagtcg ctcgcggtgt gcgaggcccg
     9001 ccgggtcgag ttcggcgagc ggcgcgcgct cgtcctggac gggctggcgc ggatcgggct
     9061 gccggtcccg gtgccgcccg acggggcgtt ctacgtctac ttcgacgtcg gcgggaccgg
     9121 cctcacctcc tggcagttct gcgaacgggc cctgcgggag gcgcacgtcg ccctcacccc
     9181 gggcaaggac ttcggcacgc acaccgccgg cacccatgtc cgcctctcct acgcggcttc
     9241 ggcggacgag ctgcgcgagg ggatcgcccg gctggggaag ttcatggcca cgctgcggtg
     9301 atccggcggg cgagggcgac gcctcagccc tttcagccat tgtcggatta gcggaggacg
     9361 gaaagcggcc atggctcgat gaatatcctt cctccgcatt cgatcgcatt cgatctctcc
     9421 gagtgggata ccgaatcacc gggaggaagg gtttggccgc accggggtgg acaccgggga
     9481 atccgagccc gacaatcgcc cgcgcgaacg acggccgccg cagcccgtcc attcggccat
     9541 cgacacgcac ctaaactcga atatccgctc gacattcgct ggtccgcagc ggcgaaaacc
     9601 gtctcttgtg ggccgcactt ccggcatcgc agcatgtatc cggattttcc acccgttcac
     9661 ggaaggagac atgcgatgga gcagccccag atggacgaga agccggtgta ccagccgccg
     9721 gcggtggccg aggtcgccga attctcggag ctgaccaccg gttgtgggtt cgacttcttc
     9781 gagatgcccg cccagcacaa catctgctga ttccaaccat cccgatcgcc acggcgcgtc
     9841 cggcgtgacg gggcgcggcc gggaccgcac tccgcccttt cctgccgggg tgcgagttcc
     9901 cggccgctgc cggaattcat tcacccattc ccacatgctt tcggaaaagc ttcttgaatt
     9961 cgggctgcaa gcagagaaga ccagggggtc gatgagcgtg atgccggaaa gtacgacgcc
    10021 gggcagcggc tggttcgcgg tgctgcccga ctgtgacgcg gcgcgggcgg cggccgcggt
    10081 gctgggcgcg gaggcgacgc ggatcgtgga gcacgcgtcc gggcggccct ggctcgtcgg
    10141 gcggtgggcg gaggacgagg cggtcgtcgc gacggtcggc gacgcccggg tggcggtggt
    10201 ggggctctcc ccgctgaccg agtcccgcct cgccgcactc gtccgggagg acgacgcgct
    10261 cggctcgctc gaccggctcg ccaccggccc ggtcggcggc tgccatctgc tggcgtcgca
    10321 gtcggggcgg ctgcgctccc agggcacggc ctcggggctg cggcagctgt tctccgcccg
    10381 gctggccggg gtcgtggtcg cctgcgaccg ggcggacgtc ctggccacgg ccgtcgacgc
    10441 cgggatcgac gaacgcctgg tggcgctgcg gctcatggac ccgctgatcc cgcaccccct
    10501 cgccgaacgc cccctgtggc ggggcgtgtc ggcggtcccg gccggtacgg ccctgctgac
    10561 ggacgccgcc ggcaacgccc gcacccgccg ctggtggcag gcccccgagc ccgaactgcc
    10621 cctcgccgag ggcgcggagc ggctggccga ggcactcgcg gacgcggtgg ccgtacgcac
    10681 cgccgggggc ggggtgatca gctcggacct gtccggcggg ctggactcga cctcgctgtg
    10741 cttcctggcc gcgcgcggcc ccgcccggct gctggccctc accctcaccg gcgcggaccc
    10801 cgccaacgac gacctctcct gggcccggcg ggcggcggcg cacctgtcgg acacggacca
    10861 ccaggtgctg ccgatggacg aactgccgcc ccactacacc ggtgtgctgc gggccggcga
    10921 aggtgtcgac gagccgttca caggtgtccg cgtccgcgcg cccttcgccg agaccgctcg
    10981 ccgtctggcg ggcatgggct cgcggctgca tctgtccgga gagggcgccg accagatcct
    11041 gtccgcgcga ccgccgtatc tgcacaccac gttccgcacc cggccacgca ccgcgctcac
    11101 acatctgcgc gccaccctct ccgcccagcg ctggcatctg ctccccaccc tgagagcgct
    11161 ggccgaccgc cgctcgtacg ggcgctggct cgcggacacc gcccgtgacc tctcccccgt
    11221 cctggccctg gacggcaccc ccgccctggg ctggcagatg ctgcggcccc aactcccgcc
    11281 ctgggcgagc ccggacgcgg cggcggccgt acgcgaactc ctctggcaga ccgccctcga
    11341 agccgaaccc ctcgcaccga cccgggggca gcacgaggtc ctgtggtccg tgcgcaacgg
    11401 cacccggctc gcccgccagc tcacccgcgt caccagtgag gcgggcctgc ccacgcacta
    11461 cccgttctac gacgaccgcg tggtcgaggc ggccctcgcc gtacggctgc acgagcgcac
    11521 caccccgttc gcctacaagc cgctcctggt gcgggcgatg cgggaggcgg tgcccgccga
    11581 actgctcgcc cgccgcacca agggcgagta cagcgccgag atgcagagcg ggctgcgcac
    11641 ccgccgcgcc gacctggcgg acctcctcga ccggccgctc ctcgccaccc tcggcctcgt
    11701 cgacgccgac gccctgcgcc gcgcctgcct cagcatgttc ccgccccggc tctcccccgt
    11761 gaccctggag gcgaccctgg ccgtcgagac ctggctccgc gcccacgcgg gccccgcctc
    11821 cgccacgccc gccatgggaa gcgaggcggc ggcatgagcg cggcaggaaa gcggaacagg
    11881 aacgcggcgg ggacgcggtt gcgacggcat gtgtccgtct ccgacgtgga ggacgggatg
    11941 gtcctgctgg acgagcgcaa gggccggtac ttcaaggtga acgcgagcgg cgcgctgatt
    12001 ctgcgggccc tgctcgacgg cgccccgccg gccgacgcgg tccgggcgct cgtggagcgg
    12061 tacgaggtct ccgaggagcg ggcggcggcc gatgtcgacg cgctcaccgc cgagttggcg
    12121 ggcaacgggc tggtggtgtc atgagcgtcc cctccgtctt ccaggaacgg cgccggctgc
    12181 ccatgcgccg gcggccgctc ccgctgctcg cggtgggcgc cgcgcatctg atcggccggc
    12241 tctccccgct gcgcatccgg cagatcctga ccgcctgttc actcggcggc cgcccggcga
    12301 cgtacgccga agccgcgcgg gcccgcgccg acgtggtcgc ggtgagcgtg cgctgcgccg
    12361 ggcagggctg tctgccccgg tccatcgcca ccgcgctgct ctgccgcgcc cggggcacct
    12421 ggcccacctg gcgcacaggg atgcgtacgg tcccgatggt cgcccacgcg tgggtggagg
    12481 cggagggccg tccggtggac gacctgccgc tcaccccggg catcccaccg ctcatcaccg
    12541 tcgcgccacg ggcgcgctcg tagcaggggg ggaatgtcgt gccgggcgac gacatcgccg
    12601 tacacgccga ggaactcagc aagctctacg ggacgcggga ggccgtggtc gggctcgacc
    12661 tcaccgtccc ggcgggccgg atcttcggct tcctcggccc caacggggcg ggcaagtcca
    12721 ccaccatcgg catgctctgc accctgctgc gcccgaccct gggcgacgcg tgggtggccg
    12781 gggcgcacgt ggtccgcgag gccgcgcggg tacggcgccg gatcggcgtc gtcttccagg
    12841 agcagaccct cgaccaggat ctgacggtca tggagagcat gcggctgcag gccgagctgt
    12901 acgggctgcc cggcgcggcg gcccgcgcgg ccggtacggc cctgctcggc ctggtcggtc
    12961 tcgccgaccg ggccgggcat gtggtccgca ccctctccgg cggcacccgc cgccgcctgg
    13021 agatcgcccg ggcgctggtg cacggccccc gggtgctctt cctcgacgag cccaccgccg
    13081 ggctcgaccc gcagacccgg gccgccgtcc gggagtatct gcggctgctg tgccgggagc
    13141 acggcatcac cgtcttcctg accacgcacc atctggagga ggccgagcac tgcgaccgca
    13201 tcgccatcat cgaccacggc gaactggtca cggagggcac gccccgcgag ctgaaggcgg
    13261 tcatcggcgc cgacctcgtc accctgcgca ccgatgacga cgagcgggtc gccgaggccg
    13321 tgcgccggtc cttcggcctg cccacggaga ccggccccga cggcgtacgc ctccgcgcgg
    13381 ccgacggcgc cgccctcgtc ccccgcctct gcgcccagct caccgtgccc gtccgctccg
    13441 tgacggtcac ctcacccacc ctcgacgacg tgttcctgca ccacacgggc cgcacgatcc
    13501 gctagcgccg cccggctctc cagaggaggc atgcccttgt cgtcggcgac cacgtccgac
    13561 tccctctcgc cccctgcccc cgacgcgacc ggcggccgcg gtgcacccga ccgccgtgcc
    13621 gggcccttcg tcgccgatct gcggaccctg cggatcctgt ggcggcggga gatgacgcgg
    13681 ttcctgcgca accgggcccg gctggtgatg gggctggccg cgccgctgct gttcctgttc
    13741 gtgctcggca acgggatcgg gtccgccggg ggcgatctcg ggcactacca ggcgttcctg
    13801 ttccccggca cgctgctgat ggtcgtgcag ggcccggccg tggccgtcgg cacggtgctc
    13861 atgtgggacc ggcagtccgg gttcctgcgc cagatgctgg tggcgccggt gcggcgcggc
    13921 gccatcctgg cgggcatctg cctgggcggt gccaccaccg gggccctgta cgcgctgccg
    13981 gtcctcgccc tcgccggtcc catggggctg ccgtaccacc cccggttgct gctcgtcctg
    14041 ggcgaggtgg ctctgctgtc gttcgcgctc accgccctcg gcgtctcggc ggccgtgtgc
    14101 atccggcgcc ccgagacctt ccagatcgtc tccggcctgg cgatggcccc ggcgatgctc
    14161 ctgtccggcg cgctgttccc cgtcggcggc ctgccgtcgt ggctcggcgc cgccgtcctc
    14221 gccaacccgc tcagctacgg cgtcgacgcc ctgcgccgca ccatgcccga cccggacccg
    14281 accaccgccg ccccggcctg gttccacgcc ggccccgagt ggtggggctg gaccccgccg
    14341 gtccttctcg aactcgccct cgtcgtgctc ccgtcactgc ttctgctgct cctcgcgggg
    14401 cgccgcttcg cccgtatcga ctgaggccgg gcggcgggtg aggggacggc tgatcacgtc
    14461 ttggtagcgg gtcgacgact cgtcaaagtg gctctatatg atcggcgttc gcatgtacgg
    14521 gggcatgtgc gggtgcaact ctgccgtttt cgttccgcgt tgccgatttc ggctcgtgtt
    14581 tgccgtttcc gttcactcct ccgtgcgtcg cgcgcccttt cagtgacacc cgacgacgag
    14641 gagaggggcc atgtcctatc cgacaccgcc ccagccgccc ggcagtgccg ggggctacgg
    14701 ccaacagccc ggtccctacg ggcaacagcc ccagcagtac ggccaaccgc cccagctggg
    14761 gtcatggccg caggaccggc cccagcagta ccccggccag gcgccctacc cgggtcaggc
    14821 accgcacccc gccccggtcc cgacccctcc cccggccaag ggcggcgcgg cccgcggctg
    14881 tctcgccggc gccctgggtt tcctcggcct gctcggcatg ctcggcggcg gtctcctggt
    14941 cggtcacgcg tactcgaacg cgagccagga cattcccaac cgtgacggct acggcccgac
    15001 catgtggcgg aacgagccgg cggacaagct gttccccgac tacctggccc cccgggtgag
    15061 cgcgacgacc acgaaggccg acagcgcgcg ggccacctgg caccgcgtcg gcatatccga
    15121 ggacaccgac tgcgcgaccg ggctgaacaa ggccacctcg gccgctgtgg cgaagctcga
    15181 ctgcgaggcg gtgctgcgcg ccacgtatgt ggacccgacg gggaacaccg tcgggacggt
    15241 cgcgctgatc gtgctgcccg cgggggagtc cgcgaagacg gagatgacca cgttcttcga
    15301 ggcggacgag gagaaactcg accccgaggt cggggtcaag gcgctcgccg tacccggcac
    15361 catcgccgcg aagtggagcg acgcgcggag caacggcggg gcggggatcg tggtccccga
    15421 agggtccctg ccgtacgtcc tcgtggcctc caccggcgcg gtcgacggcc gcaaggcagg
    15481 ccatctgccc ggcgagttcg gcagccacaa ctgggacgcg ggcgacgacc gcgcgccgtg
    15541 gcggggcgcg gcgaaggccc tgtgcgacga cctgaactac cacctcggcg acctgatcct
    15601 ggagacctca tgagcacggg cacgggcatg agcaggggtg cgggcatagg catgggcagg
    15661 accgtgcggc gggccggcgc ggccacggcg gccgccgccc tgctgctcgg cacggcggcc
    15721 gcgggtgcgg cgagcgcggc cgagacgacc ccgcagtcct gggagtacca ggcgctgaag
    15781 ctgggcgctg cacagcggct cgcgcagggc gagggcgtca ccgtcgctgt cctggacacc
    15841 ggcgtcgagg cggaccaccc cgcgctcaag ggcaaggtga ccacgggccc cgactacatc
    15901 ggggacggct cggactccga cgaggcggac aacgagggcc gccacggcac ggcgatggcc
    15961 tcggacgtcc tcaaggtcgc cccgaaggcg aagatcctgt cgatccgggt gaccgacgga
    16021 agcggggagc cggggtacag caagggcggc aacccggtcg cgcagggcat caactacgcc
    16081 atcgagcacg gcgccgacgt gatctccatg tcgatcggcg accagctcct cggcagcagc
    16141 tacgacgagg acgaggccga cgccctgggc cgcgcggccc tggcgggcgt ccccgtcctc
    16201 gcctcggcgg gcaacaacgg cgacctgttc aacgacgccc agtacccggc gggctacccg
    16261 ggcgtgatcg cggtcgccgc gctccagcca ggcggcaccc gggccgcgtt ctccaccgtg
    16321 cggacgtaca acgcggtcgc ggcacccggc gtcgacatca tgagcgcgag caacaccggt
    16381 ggctacgcga cgatcgacgg cacctcgccc gcgacggccc tcgcgtccgg tgtcgtcgcc
    16441 ctgatgctct cccacaacga caagctgacc ccggcccagg tccggacgat cctgaccacg
    16501 accgccgggc acgccgccca gggccacagc ccgctggacg gctacggcgt catcgacgcg
    16561 cccgccgcga tcgaggccgc cgagaagccg ccggcggacc ggacggagcc ggtggcgtac
    16621 aagggcgagg agcacctcgg caccccggac ggcacctcga agacgaagca ccccgagctg
    16681 gacacggaga tggtgacgat cgggggcggc gcggcggccg tcgggctgct gatggccgtg
    16741 ggggccgtac tgatcggccg ggcggggcgg cggcgcgcga caccggccgg cggccgtgcc
    16801 gtgacccgct gacgcatatc ttggcgttca tgcagtccta cacaatcggt caggccgcgc
    16861 ggctgctcgg ggtcagcccc gacaccgcgc ggcggtgggc ggacgcgggc cgggtggcga
    16921 cccggcgcga cgagagcggg cgccggctca tcgacgggaa ggacctcgcg gccttctccg
    16981 tggagctggc ctcggacacc gccgacgagg ccgacgtgcc gtacacgtcg gcccgcaacg
    17041 ccttcgccgg catcgtcacc gccgtgaagc tcggtgacgt ggcggcccag gtcgagatcc
    17101 aggcgggccc gcaccgcctg gtctccctgc tcacccgcga ggccgtggag gagctcggcc
    17161 tggaggtcgg catggaggcc acggcccggg tgaagtccac gaatgtgcac atcgaccgga
    17221 cgtgaacggc acacccatgg gaacgcacat gcgctcccac aagcccaggt gacctggctc
    17281 atgcgatgcc acaggagact tacccctcgc acatgcgtca agatggtcgg cgtagcgtcc
    17341 ggcttgctgg gtgggccggc tccgagggag tgggtaggga gatcgtgatg atccgttccg
    17401 tgcgtctggt cgccggcgtg ggcgccgccg cgctgctggt gaccctgagc gcctgctcct
    17461 cctccgacga ggcgtcgccc gccgcgtccg gctcctcgga cgagctctcc ggcacggtga
    17521 ccgtgttcgc cgccgcgtcg ctgaaggaga gcttcacgac gctggggaag cggttcgagg
    17581 aggagcaccc cggtacgaag gtgaccttca acttcggcgg cagcgactcc ctcgccgcga
    17641 gcatcaccgg cggcgccccg gccgacgtgt tcgcctctgc cagcccgaag acgatggcga
    17701 tcgtgacgga cgcgggcgac gcctccggcg cacccgccac cttcgtccgc aaccagctgg
    17761 agatcgtgac cctgccgggc aaccccgacc ggatcgcctc cctgaaggac ctcaccgagt
    17821 cgggcctcaa ggtcgtgctg tgcgacaagg aggtgccgtg cggcgccgcc acgcagaagg
    17881 cgctggaggc cagtggcctc aagctcacgc ccgtctcgta cgagcaggac gtcaaggcgg
    17941 ccctgacgaa ggtcgagctg aaggaggccg acgcggcggt cgtctacaag accgatgtgc
    18001 aggccgcggg tgacaaggtg gagggcgtgg acttccccga gtcggccgac gccgtcaacg
    18061 actacccgat cgccctcctc aaggacgcgc ccaacgccga cgccgccgag gcgttcatcg
    18121 agctggtgcg gtccgccgag ggccgacagg tcctgaccgg ggccggattc ctggagccgt
    18181 gagcaggccc tccggcagcc cggacgcgtc cgggaccgtg gtggcgggcg gggcccgacg
    18241 ggtacggcgg gtacggcgcc tgcgcggctc cgtccccgtc ccgctgctcc tccccgccct
    18301 gatcggcgtc gccttcctgg tgctgccgct ggtcgcgctg ctcgtgcgga cgccgtggtc
    18361 gagcctgccg gagcagctga ccagcgcgga ggtgtgggag gcgctgcggc tgtcgctggt
    18421 gtgcgcgacg ctggccacgg tggtgagcct ggtgctgggg gtgccgctgg cgtgggtgct
    18481 ggcccgggtc gagttcccgg gccgtggtct cgtacgggcc ctcgtcaccc tccccctggt
    18541 cctgcccccg gtggtcggcg gtgtcgccct gttgatggcg ctcggccgca acggggtcgt
    18601 cgggcgcctg ctggacgact ggttcggtct cacccttccc ttcaccacca ccggggtcgt
    18661 gatcgccgag gcgttcgtgg cgatgccgtt cctcgtcatc agcgtcgagg gcacgctccg
    18721 ggccgccgac ccgcgctacg aggaggccgc gacgacgctg ggggcgtccc ggttcaccgc
    18781 gttccgccgg gtgaccctgc cgctgatcgc ccccggcgtc gccgccggcg cggtcctcgc
    18841 ctgggcgcgg gcactgggcg agttcggcgc gacgatcacc ttcgccggca acttccccgg
    18901 ccgcacccag accatgcccc tagccgtcta cctcgccctc cagagcgacc cggccgccgc
    18961 gatctccctg agcctcgtac tgctcgcggt gtcggtggcg gtgctggcgg gcttgcggga
    19021 ccgttggatg acggcgtcat gacgcaagcc ggcgaagcgg cggaccggcg caatcgcgag
    19081 ccggcgcaat cgcggtccgg cggcatgccg agcaagcagg ttggtgagtg agcgaagtgc
    19141 cgatgagtga aaccccggcc gccgtcgatc cggctctcgc cgccaacggc gccgaccgct
    19201 ccgaagggct ggacgcccac ctcgtcgtcc agcgcggtga cttccgcctg gacgtctccc
    19261 tgacggccgc ccccggcgac gtcgtggccc tgctcggccc caacggcgcc ggaaagacca
    19321 ccgcgttgcg cgccctggcg ggcctgaccc cgctcaccgg cggccatcta cggctggagg
    19381 gggccgcgtt ggagcgtacg gcgcccgagt cccggccggt cggtgtcgtc ttccaggact
    19441 acctgctctt cccgcacctc accgccctgg acaacatcgc cttcggcccc cgctgccagg
    19501 gcgcgaccaa ggcggaagcc cgcgcgcagg ccgccgagtg gctggaccgg atgggtctcg
    19561 ccgagtacgc cgggaccaag ccgcgccgcc tctccggcgg ccaggcccag cgcgtcgccc
    19621 tcgcccgcgc cctcgccacc cgcccccgcc tgctgctcct cgacgagccc ctcgccgcgc
    19681 tggacgcccg cacccgcctc gacgtacggg cccaactccg gcgccatctc gccgagttcg
    19741 aggccgtcgc cgtactcgtc acgcacgacc cgttggacgc catggtcctg gccgaccggc
    19801 tcgtcgtcgt cgagcacggc cgggtggtcc aggagggcac cccacgcgac atcgcccgcc
    19861 acccccgcac ggactacatc gcccacctgg tcggcctgaa cctgtaccgg ggacaggccg
    19921 agggccacgt cgtacgcctc gacacggagg gcatggcgac cacaggagcc gtaggagaca
    19981 caggcggcag gggcccggcg ggcgcgccga cgaagaacgc aggccgccct gcggacacgc
    20041 cggcgaaaac cacaggccgc ccggcgggcg cgccaacgaa aaccacaggc cgcccggcgg
    20101 acacgccggc caaaaccaca gaccgcccgg cgatcacgac caccgaggac ctcacgggcc
    20161 ccgtcttcgt cgccttcccc ccgagcgccg tgaccctcca ccgcgaccgg cccaccggct
    20221 ccagcgcccg caacctctgg cggtgcgagg tggccggcct ggaggtccac ggtgaccaga
    20281 tccgcgccga cctgacgggc gaactcccgc tcaccgccga cctcacgacc gtggcggccg
    20341 ccgaactcgg cctccacccg ggaacaccgg tatgggtgac ggtgaaggcg acgcagaccc
    20401 acgcgtatcc ggcgtgagaa cacccacgtc aggtcagctg atcaccactc gggagcgagc
    20461 gtccgcccgc accagcccag gatctccggg tcggccggat ccgcctcgtc cccgtcgacc
    20521 cagtcgtaca gcttcacgta cgacccgccc gacgagccgg gcagccgcga cacgtacgcc
    20581 ccctcgcggt ccgcgaacaa ccggggcgcg gagatcccca gcgcctccgc ggcgttccgc
    20641 aacgccgcct cccgccccac ctgctcctcg tcacactcga acagaagctc cttcaccgcc
    20701 cacgagacac cgccgccgcc cccgcccgac agccgccaga tctgccccag cgcgccacgg
    20761 gcgacgggct ccatgcgcca tgccccggcg ccgaggccgt acgcctccgc gatgaagtcc
    20821 gctctgctcc gcatgtggtc accttccggt cggccaacgg ggtctgcctc ttcgcatcca
    20881 cccctccgta tctgcccctc gacatgtgaa cagacccgtg cgccgcatca ctcccgcacc
    20941 cggccctccc gcaggaacaa cgcactggtg agggtgccca ggagcaccac ggcggcgttc
    21001 agggcgatcg cgaccttgag cccgccgagc acggccgcgg ccccgctgcc gccgagggcg
    21061 gccgtggcga cggcgctcat gatgggcgtg cccatggtga tgccgatctg ctgggtcatg
    21121 gtggccagac cggtggcgag gccctgctcg tggtcggcga gcccggaggt ggcggtgacc
    21181 atgaagccga cgatgaccag catgttgccg acaccgccgg cgaaggtggc gaccagcagc
    21241 agccacatcc acgaacggtc gtcgccgagc ccgaggagcg cggcggtgaa cacggtctgg
    21301 acgacacccc cgacgatcag cgtccgcctg gtgccgagcc ggccgatgac cctgggcgcg
    21361 agggtgccgc cgacgaccgt cccgacgccc agcaccccga acgacagccc ggcggcgagc
    21421 ggtgagaacc cgagcacttc ctggaggtac agggtgagca ggaagaccag cgacgtctcc
    21481 gtgaggaagg cgatcagacc ggcgacgttc ccccaggcca ccgaccgctt cccgagcacc
    21541 ccgaccggca ccagcggcgc ggccgcccgg cgctcgacgg cgtggaagac gacgagcagg
    21601 acggcaccca ccgcgagcga cagcagcgcg gcgggcgagc cccagccgtg ctcccccgcc
    21661 cgggtcagcc cgaggaccac ggccagcaga ccgagcgtga cgctcacggc acccggcacg
    21721 tccagcctcg gccgctcctg gatccgggac tccttgatga ccgtcggcgc gatgacgagg
    21781 acggcgaggg cgacgggcac gttgacgaag aacgcccagc gccaggagag cagatcggtg
    21841 agcagcccgc cgaggatcgc gccggtggtg aaaccggccg acatcaacgc cccgttgaga
    21901 ccgagcgcct tctcccgcag cggcccctcc gggaaggagg tcgtcagcag cgacagcccg
    21961 gccggggtga cggcggccgt cgccagcccc tggaagaccc gggctgcgat cagcacctcc
    22021 ggatcccgcg cgagcccgcc gaccagcgag gccacggcca gcaccaccag cccgccgagg
    22081 aagagacggc gacgcccgaa cagatcggcc acccgcccga agagcagcgt gaaaccggcc
    22141 gcgcacaacg cgaacgccgt gccgatccac tgcagccccg ccagcgagaa ccccagcccc
    22201 tccccgatca cgggcaacgc cacgttcagg atggagaagt ccacggccag catgaactgg
    22261 gccgcgagca gcaccacgag ggtcagccgg agccgggggg tgagtgcggt ggcggcagcc
    22321 gggccgggcg ccgtatcgcg tcggcggcgg ggcgccgtac cggccgcctc cgagtctgtg
    22381 acggacatgt cgtcgagtcc cttcctctcc tcgtgcaccg tccgcgcgca tccgtcgtac
    22441 gtcatcgtcg tcggcgtacg tcctcgtcct cggcgtacgc cttctcgtcc tcggcgtacg
    22501 tccatgtcgt acgccctcgt cgtacgacct cacgcgcggc tacggagaga ggctcgcccg
    22561 tcc
//
