LOCUS       NZ_CP102512            22586 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces sp. CA-210063 chromosome, complete genome.
ACCESSION   NZ_CP102512
VERSION     NZ_CP102512.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CA-210063
  ORGANISM  Streptomyces sp. CA-210063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10859970)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Jorgensen,T.S., Klitgaard,A.K.,
            Mourched,A.S., Blin,K., Oves-Costales,D., Genilloud,O., Larsen,T.O.,
            Tanner,D., Weber,T., Gotfredsen,C.H. and Charusanti,P.
  TITLE     Identification of the Biosynthetic Gene Cluster for Pyracrimycin A,
            an Antibiotic Produced by Streptomyces sp
  JOURNAL   ACS Chem Biol 17 (9), 2411-2417 (2022)
   PUBMED   36040247
REFERENCE   2  (bases 1 to 10859970)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Assembly Name                     :: M642_aaa1.6.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 55.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 11:12:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,501
            CDSs (total)                      :: 9,410
            Genes (coding)                    :: 9,051
            CDSs (with protein)               :: 9,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 141 of 359
            Pseudo Genes (incomplete)         :: 302 of 359
            Pseudo Genes (internal stop)      :: 23 of 359
            Pseudo Genes (multiple problems)  :: 101 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 899193
            Orig. end                         :: 921779
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102512.1.
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22586
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="3"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..22586
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22586
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12586](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12586)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    978..992
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.24"
                     /tool="antismash"
     misc_feature    complement(995..1010)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.55"
                     /tool="antismash"
     misc_feature    complement(1022..1037)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.84"
                     /tool="antismash"
     gene            complement(1280..1948)
                     /locus_tag="JIX56_RS03925"
                     /old_locus_tag="JIX56_03925"
     CDS             complement(1280..1948)
                     /NRPS_PKS="Domain: PKS_ER (53-163). E-value: 2.3e-10.
                     Score: 32.0. Matches aSDomain:
                     nrpspksdomains_JIX56_RS03925_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543866.1"
                     /locus_tag="JIX56_RS03925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03925"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_257537360.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.4e-08, bitscore:
                     33.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAAVVRESGGPEAIEIVDVATPEPGPGEVLVKVAAASVNFADVM
                     VRTGLKVALEPGEWLLVSGAAGGVGLFTVELARLRGLNVIAQAGPADEKLVREAGARLF
                     VSRDDDLVPTVRRLVPGGVDGAVDAANLAAGAADAVRHGGVFVSLLNSAPMARRQVRMI
                     NMAWHTDAGRLAKLAAYAGAGLISLRVARTYSLEQIADAHRALAEGGLRGRIVLVPDHR
                     "
     aSDomain        complement(1460..1789)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIX56_RS03925_PKS_ER.1"
                     /evalue="2.30E-10"
                     /label="JIX56_RS03925_PKS_ER.1"
                     /locus_tag="JIX56_RS03925"
                     /protein_end="163"
                     /protein_start="53"
                     /score="32.0"
                     /tool="antismash"
                     /translation="LEPGEWLLVSGAAGGVGLFTVELARLRGLNVIAQAGPADEKLVRE
                     AGARLFVSRDDDLVPTVRRLVPGGVDGAVDAANLAAGAADAVRHGGVFVSLLNSAPMAR
                     RQVRMI"
     CDS_motif       complement(1718..1780)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIX56_RS03925_0001"
                     /evalue="9.30E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="JIX56_RS03925"
                     /protein_end="77"
                     /protein_start="56"
                     /score="15.1"
                     /tool="antismash"
                     /translation="GEWLLVSGAAGGVGLFTVELA"
     gene            2011..>2283
                     /locus_tag="JIX56_RS47605"
                     /pseudo=""
     CDS             2011..>2283
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="JIX56_RS47605"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSCEEGPLLPGSSRARQVCGRRRTVGGVETTIGEFLRIRRERITP
                     EQAGLPPSLTRRRVPGLRREEVALLAGVSPDHYQRLEQGRTAQVSD"
     misc_feature    2035..2037
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2517..2882
                     /locus_tag="JIX56_RS47610"
     CDS             2517..2882
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.4"
                     /locus_tag="JIX56_RS47610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_306819817.1"
                     /transl_table=11
                     /translation="MRLLTGRRPDDAKLAALVGELAIRSEPFQRLWATGDVREKRLGVV
                     RVVHPVVGTLEFDYHMLTVPARPDRSLITYLPRLGSPTAEALGMLLSWVAGRTGPAGRE
                     VPAAAPESDGDAGPATA"
     gene            complement(3055..3489)
                     /locus_tag="JIX56_RS03935"
                     /old_locus_tag="JIX56_03935"
     CDS             complement(3055..3489)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.4"
                     /locus_tag="JIX56_RS03935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03935"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_257537361.1"
                     /transl_table=11
                     /translation="MTPEETTTWSLARLNTAFFHHYDRREYDELLELFAPDALYEVHGR
                     KLRGHAEILDVLHARSGPEVTVRHLVTNQHFHTIGDGSAQGTVSLLAYAGPTPVDEGPA
                     LYPAANAGHIVELNDHYRLDSGHWKITHRATHPILAPALN"
     gene            complement(3486..4175)
                     /locus_tag="JIX56_RS03940"
                     /old_locus_tag="JIX56_03940"
     CDS             complement(3486..4175)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012976.4"
                     /locus_tag="JIX56_RS03940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03940"
                     /product="hypothetical protein"
                     /protein_id="WP_257537362.1"
                     /transl_table=11
                     /translation="MPLYGELFQGGRDGYTPSEDVKSPTVIPGSPRIDNPGTLPMRPDE
                     PGTPLVVSGRVLDGHGQPLAGAKLEIYHAANNGNYSGLYDDGVPKYNLRGHLFTDADGR
                     YTFTTVTPVAYADAYAMAIDRVVEAAAAIGRSLYRPAHIHYEVHHPDLITPWFGEIYFK
                     GDPVIPVDFVGPKLAHPALQADTALHEDPEDIAAHGFQGPYRSMEFDFVLKTRTSPDTI
                     TPKGEKA"
     gene            complement(4594..5142)
                     /locus_tag="JIX56_RS03945"
                     /old_locus_tag="JIX56_03945"
     CDS             complement(4594..5142)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIX56_RS03945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIX56_03945"
                     /product="hypothetical protein"
                     /protein_id="WP_257537363.1"
                     /transl_table=11
                     /translation="MPGLTMVAPSEATVGNLQPQIEYVFYGAVAATHAVLPAMREAGVG
                     TLLFTTGGGSVDLVPMLGNVNAAGAALRNWVNNLANELAGSGVHAAHVAINVWIGDGGP
                     EGFPSVPRPPAHRRPLPAGHARHQQLTQDRPAMTFELGVYSFGNTPRRADGSRGPTAQA
                     LRDVLEAIKLADEVGLDFW"
     misc_feature    complement(5274..5288)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(5448..6386)
                     /locus_tag="JIX56_RS03950"
                     /old_locus_tag="JIX56_03950"
     CDS             complement(5448..6386)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (15-299). E-value: 1.1e-32.
                     Score: 105.3. Matches aSDomain:
                     nrpspksdomains_JIX56_RS03950_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382508.1"
                     /locus_tag="JIX56_RS03950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03950"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_257537364.1"
                     /sec_met_domain="ADH_N (E-value: 6.2e-10, bitscore: 38.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1e-08, bitscore:
                     34.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAATLDSVPSPPAVAEVETPRPKAGELLVKVAAASLNGFDLATA
                     AGYTQAFMEHRFPLVLGQDFAGTVEELGEGVYGFAVGDAVFGVVLKPFLGAGSLAQYVT
                     VPAGHGVAHIPVGLTVGDAGALGVAGATAQVSLDAVALSEGETVLVSGASGGVGALAVQ
                     LAASRGAKVVATARPGAQADFVAGLTGAEVHVVDFTGDLEGQVRAIAPDGVDAVLHLAG
                     DGPAPAALLRPGGQLASATGLSQDDVKGQEVTVHAIMATPGAQILTSLAEQVASGALRV
                     PVTATYSLEQAPEAFAAFGASTPGKIAVTCA"
     aSDomain        complement(5490..6341)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIX56_RS03950_PKS_ER.1"
                     /evalue="1.10E-32"
                     /label="JIX56_RS03950_PKS_ER.1"
                     /locus_tag="JIX56_RS03950"
                     /protein_end="299"
                     /protein_start="15"
                     /score="105.3"
                     /tool="antismash"
                     /translation="AEVETPRPKAGELLVKVAAASLNGFDLATAAGYTQAFMEHRFPLV
                     LGQDFAGTVEELGEGVYGFAVGDAVFGVVLKPFLGAGSLAQYVTVPAGHGVAHIPVGLT
                     VGDAGALGVAGATAQVSLDAVALSEGETVLVSGASGGVGALAVQLAASRGAKVVATARP
                     GAQADFVAGLTGAEVHVVDFTGDLEGQVRAIAPDGVDAVLHLAGDGPAPAALLRPGGQL
                     ASATGLSQDDVKGQEVTVHAIMATPGAQILTSLAEQVASGALRVPVTATYSLEQAPEAF
                     AAF"
     CDS_motif       complement(5892..5954)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIX56_RS03950_0001"
                     /evalue="1.40E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="JIX56_RS03950"
                     /protein_end="165"
                     /protein_start="144"
                     /score="20.8"
                     /tool="antismash"
                     /translation="GETVLVSGASGGVGALAVQLA"
     gene            6486..7178
                     /locus_tag="JIX56_RS03955"
                     /old_locus_tag="JIX56_03955"
     CDS             6486..7178
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382513.1"
                     /locus_tag="JIX56_RS03955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03955"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_257537365.1"
                     /transl_table=11
                     /translation="MTSPPSDQTPSRQPGTGLRADAERNRDRILAAARRLYATEGLGVS
                     MTSVAREAGVGKATLSRRFATREELVNAVFADRMDAYADAVTAALDDPDPWHGFTGYIT
                     AVCAMQAADRGFADVLTMTFPTAKALEARRAEAYQSLLELIAHAKDTGHLRDDFTHQDV
                     VILLMANAGVIAATGDAAPDTWRRLVGHMLRSYAAPGAPIPALPEAPAPTVLYRAMVRL
                     SRTGPAAT"
     gene            complement(<7326..7556)
                     /locus_tag="JIX56_RS03960"
                     /old_locus_tag="JIX56_03960"
                     /pseudo=""
     CDS             complement(<7326..7556)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038607.1"
                     /locus_tag="JIX56_RS03960"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03960"
                     /product="aminoglycoside phosphotransferase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEVKVVVAHSERATLRVGGMFLKVDVDQARIDVEVEAMSLAPVP
                     TPEVLWRKPPVLATAALPGTTLGRLGGPSTGS"
     gene            complement(7877..9034)
                     /locus_tag="JIX56_RS03965"
                     /old_locus_tag="JIX56_03965"
     CDS             complement(7877..9034)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978802.1"
                     /locus_tag="JIX56_RS03965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03965"
                     /product="hypothetical protein"
                     /protein_id="WP_257537366.1"
                     /transl_table=11
                     /translation="MTAVTDKVGSVSRQRYEQIVAELRDVVQQQTKGQFLIGDRALEIE
                     RMQLRGGQHEAAPGEELLTVRQALFMHPAGSHDPPVDAARFTAPVMTMRGAVATADTPS
                     GAVRFLGAHLGLLDCDGARLANTSGPALHADGLRVDHSVFLRAGFRATGAGHAVLALNG
                     LSGEGSLFLDTSGVTRSGQATGALVGIDGLTYADLPAPVGLSRWLELLRDHTPGYSAQP
                     YQQLAAVHRAAGHDSEVRDILMAQRRDQIDRGGLRRRDRAWARFTGLALGFGYQPWRAL
                     LLLFAVLAGSVALAVVLGGPGGLGHTARASTPTTPCSVVERVGVGLDLGLPVVKTGARD
                     LCAPVLTTGTPAGQTLTVAGWLLQLAAWALATLFVAGFTGAVRKT"
     misc_feature    complement(9797..9811)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.58"
                     /tool="antismash"
     gene            complement(10001..12586)
                     /locus_tag="JIX56_RS03970"
                     /old_locus_tag="JIX56_03970"
     CDS             complement(10001..12586)
                     /EC_number="4.1.99.1"
                     /NRPS_PKS="Domain: Beta_elim_lyase (447-823). E-value:
                     1e-75. Score: 246.6. Matches aSDomain:
                     nrpspksdomains_JIX56_RS03970_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114547.1"
                     /locus_tag="JIX56_RS03970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03970"
                     /product="tryptophanase"
                     /protein_id="WP_257537367.1"
                     /sec_met_domain="indole_PTase (E-value: 9e-145, bitscore:
                     481.2, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIGSGTGSTGSDRTLGGLVTGQLLRLCQVSGLGRSDAETYAHV
                     LNDSLGAVAERPLDLPPPSRTFLSDDSTPVEFSLSFTPDAPPTVRVLLEPGCDADSLRD
                     NGRAGLRVVRSMARRWAFATDQLDVLEDLFLPTDPQGPLALWIALELRPGGVPKAKVYL
                     NPAAAGATRAAETLREALDRLGHRHAFDALPPADGYPFFALDLGDWAAPRVKIYATHHG
                     LPTTAAGGLCRMESGPDNQTLEEFLRTAGGFDDGTQHPSALRATFDRRPVLTCHSFTRT
                     TGGPTGFTLHVPIRDYVRDDAEALQRAGAVLGRHGLDTGALARSLGAITPRRPQDGAGL
                     IAYVALAHEQDQPPRVTTYLSSEAYEVRPPNTPPSGYGTPSSGRHEPSRRHINHAATRS
                     TSGARTGMEPYRIKVVEPIALTTRQQREAALERVHYNLFDLRAEEVTIDLLSDSGTGAI
                     SAAQLAAGMEGDESYAGSRSFYRFHETVTELTGYKHILPAHQGRAAERILFTTLLEPGG
                     IVLSNTHFDTTRANVQLAGCQAHDIPCAEARDLDSAHPFKGNIDLAVLRRTLEGPDGSR
                     VRVVIMTITNNGGGGQPVSMENLKQTAEICRRHGVPMILDAARFAENAWLVTRHEEAYR
                     GRTPRQVAEEAFRLADGCVMSAKKDGIVHIGGFIGLNDPELAEKCERLLIATEGFATYG
                     GLAGRDLDMMATGLLEVTEPAYLAERADVASHLADRVRAAGVDILEPPGLHALYLNAGR
                     LLPHIPPHHYPGHALACRLYLEGGIRSAELGSLYLGEEDEDGNPTKSAPYELVRLALPR
                     RVYTRSHYDHVGRTLERIAKGAESVRGYRIVDQSPILRHFRAKLQPVTG"
     aSDomain        complement(10118..11245)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIX56_RS03970_Beta_elim_lyase.1"
                     /evalue="1.00E-75"
                     /label="JIX56_RS03970_Beta_elim_lyase.1"
                     /locus_tag="JIX56_RS03970"
                     /protein_end="823"
                     /protein_start="447"
                     /score="246.6"
                     /tool="antismash"
                     /translation="DLLSDSGTGAISAAQLAAGMEGDESYAGSRSFYRFHETVTELTGY
                     KHILPAHQGRAAERILFTTLLEPGGIVLSNTHFDTTRANVQLAGCQAHDIPCAEARDLD
                     SAHPFKGNIDLAVLRRTLEGPDGSRVRVVIMTITNNGGGGQPVSMENLKQTAEICRRHG
                     VPMILDAARFAENAWLVTRHEEAYRGRTPRQVAEEAFRLADGCVMSAKKDGIVHIGGFI
                     GLNDPELAEKCERLLIATEGFATYGGLAGRDLDMMATGLLEVTEPAYLAERADVASHLA
                     DRVRAAGVDILEPPGLHALYLNAGRLLPHIPPHHYPGHALACRLYLEGGIRSAELGSLY
                     LGEEDEDGNPTKSAPYELVRLALPRRVYTRSHYDHV"
     CDS_motif       complement(11603..11686)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIX56_RS03970_0001"
                     /evalue="7.90E+00"
                     /label="C2_DCL_024-062"
                     /locus_tag="JIX56_RS03970"
                     /protein_end="328"
                     /protein_start="300"
                     /score="-1.1"
                     /tool="antismash"
                     /translation="DAEALQRAGAVLGRHGLDTGALARSLGA"
     misc_feature    complement(12056..12058)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12182..12184)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12801..12815)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.16"
                     /tool="antismash"
     misc_feature    12875..12888
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.15"
                     /tool="antismash"
     gene            complement(12918..14258)
                     /locus_tag="JIX56_RS03975"
                     /old_locus_tag="JIX56_03975"
     CDS             complement(12918..14258)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475230.1"
                     /locus_tag="JIX56_RS03975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03975"
                     /product="cytochrome P450"
                     /protein_id="WP_257537368.1"
                     /transl_table=11
                     /translation="MTSDSTFPAPPPGCPAHDSGQRVPLYGPDFAADPQAYYAHMRHYG
                     PTAPVEIAPGVDATLVTDHATALKLLQDPGNFRKDARRWRDVAEGKVGPDSPVVPMLGY
                     RPNCMFTDGAEHARLRQAVTDSLAKVDSRRLSDMTKRASDYLMAQVASRGSVDLMNDYV
                     KQLPLLVFNELFGCPADIGDRVVFGISGVFEGVNAEKANEVLGQAVFELVALKRARPAD
                     DVTSYLMRHQARLTDEELVHQLILLLGAGAEPLRNLIGNTLHRLLLHDRYADGGLIEEA
                     IDDTLWENPPMANYAPHYPAADMEFGGTKLRAGDLVLVSMTAANTDPALAAARQTGGRR
                     AHLSWSAGPHACPSKELARLVTMVAIENLLNRLHDIELAVPEDSLTWRPGPFHRALAAL
                     PCRFTPQVVERPNPPQATQAPALGENTPAARKTERGVWGSFLSWLKG"
     gene            complement(14272..14865)
                     /locus_tag="JIX56_RS03980"
                     /old_locus_tag="JIX56_03980"
     CDS             complement(14272..14865)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="JIX56_RS03980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03980"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_257537369.1"
                     /transl_table=11
                     /translation="MVSSPSLDERAYVPDGETQTAVKILVVGHFAVGKTTFIGSISEIS
                     PLSTEETMTQAGEAIDDLKGVQGKTTTTVAMDFGRLTVSDRVVLYLFGTPGQLRFVQMW
                     EDMARGALGALVLVDPERLADSFAVIDLIEQYGLDYAIAVNHFDGTSIRDARALREALD
                     LLDDTPIVTCDARDERSSAEALITLVRYLMDRAR"
     gene            complement(14840..15217)
                     /locus_tag="JIX56_RS03985"
                     /old_locus_tag="JIX56_03985"
     CDS             complement(14840..15217)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="JIX56_RS03985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03985"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_257537370.1"
                     /transl_table=11
                     /translation="MTDSDKQEPEAAELVRPYVITGGRSLPGESQFSLITLVTAVADQQ
                     QRPARLSPEEQDLLSMCVGGYLSVAEIAGHTQLPVGVVKILLAALSEAGYLVTRPPVPR
                     APVANLQILEEVLNGLQSKFG"
     misc_feature    complement(15176..15178)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15214..15615)
                     /locus_tag="JIX56_RS03990"
                     /old_locus_tag="JIX56_03990"
     CDS             complement(15214..15615)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475236.1"
                     /locus_tag="JIX56_RS03990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03990"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_257537371.1"
                     /transl_table=11
                     /translation="MNNDLSWMLDSALEIPGALHAVLVSSDGLLRARSKGVDKDDADKA
                     AAAMSGMQSLSRSLAFFCSRSDLRWQQTLVEFDGGWIFLISAGDGAYLAVSASSDIDMA
                     DITFRMQQLVGQLGKVMTAPPRESSVIRP"
     gene            complement(15612..16820)
                     /locus_tag="JIX56_RS03995"
                     /old_locus_tag="JIX56_03995"
     CDS             complement(15612..16820)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475238.1"
                     /locus_tag="JIX56_RS03995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_03995"
                     /product="ATP-binding protein"
                     /protein_id="WP_257537372.1"
                     /transl_table=11
                     /translation="MTQYIQNPALWALVVVTLAAVALIVRQRRAARTLRQEIAGLRKHY
                     GELESQYSESVRAAQQEAEGETRTALKSAMRTLQGLAAEQQRIISGLQRKYGDSVMLQD
                     LLEIDHMNAQFGRRAQSIAVLCEGWLGRHRDTASVYDVVRSAQGRIRHFQRAQILSKVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINVRSVPKGVCIVVDDAGVGMNEEEK
                     ARAERLLTSERVTGVSGLGNPPQFGFAVIGVLCERFGFTVSVDSTSPYGGVRAVVLLPD
                     ELLTSMPEPRQPTVPVDSVAPKEVPPPPAEERPSVYETDPEPSLPIATTEDGLPKRRRK
                     RPMALVSTDSPASPATRRRSEDTAAIMAAFKQGTDAGRATHPQAGERPSSTRDASSEGH
                     EAE"
     misc_feature    complement(16719..16721)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17344..18840
                     /locus_tag="JIX56_RS04000"
                     /old_locus_tag="JIX56_04000"
     CDS             17344..18840
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009308287.1"
                     /locus_tag="JIX56_RS04000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_04000"
                     /product="FAD-binding protein"
                     /protein_id="WP_257537373.1"
                     /transl_table=11
                     /translation="MALKEPGPVNRRQFLFRCGAGTVALVAGFDLLARQWVTEAAAAES
                     ASFATAPPLDGTLTFDAESIAANSHDQGNIVFRTPCAVLRPGSVQDIRKMVGFCADHDI
                     TVAPAGTHHAMFGQPLVSGGLIIEMQSLNTIHSIGTDGADVDAGVLWKDVIEAAYEQGL
                     TPASITSYIRTTVGGTLSMGGIGMMSAYRAGAQVDHAQQLQVVTGEGRLKWCSGTQNSD
                     LFEAALAGLGQCGVITRATIDLVPAKRLARTYRIEYSDIPTFFQDIRVLANRGEFDSLG
                     SIPQPGTAQPLTLWATVFHNPGDVPDASHLLRGLSSAADAAAFEDYPYLDYISLVTTMY
                     DAFAANLDWDAKVKPWSDLFLPDGAVEQYVESVFPSLTAEDLGPTGFGLIFPMLRSSYG
                     RPLLRLPDEAGGPWVWLVSVLTDSAESGPDPEFASRMMDRNYRFYQEAAALGGVRYPHG
                     ACAFTQADWQAHYGSMWAQFLSWKNHYDPSGILTPGPSIF"
     misc_feature    complement(19057..19072)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.06"
                     /tool="antismash"
     gene            19282..19899
                     /locus_tag="JIX56_RS04005"
                     /old_locus_tag="JIX56_04005"
     CDS             19282..19899
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009328790.1"
                     /locus_tag="JIX56_RS04005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_04005"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_257537374.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 9.4e-09, bitscore:
                     34.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDLAGPDDDGLPPDRTQAILEAAKEVASLLKAGGHSFALAGGVA
                     VYAHGGPGTLQHDVDFCVLPEDIDAVTVTLEAAGLKVVEPPEDWLLKTRSQGQDVDLIF
                     RPSQRPVSRELLDRAEMLSVESVWMPVLAPTDLLIGRLMAFSEHYCDFGAVLPIARTLR
                     EKIDWSRVRRECGAEPMPDAFLYLLERLNVIEPEETGDGDRT"
     gene            19883..20194
                     /locus_tag="JIX56_RS04010"
                     /old_locus_tag="JIX56_04010"
     CDS             19883..20194
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321225.1"
                     /locus_tag="JIX56_RS04010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_04010"
                     /product="BON domain-containing protein"
                     /protein_id="WP_257537375.1"
                     /transl_table=11
                     /translation="MATGHDNPPVSGPGDGAAHPAAHTEYRIAHLEERLARSDLAELGM
                     RIEARGDAVHITGTASTVADRETILRIAAAELPGVAVRADITLADVTAPDPDRSEELS"
     gene            20191..20931
                     /locus_tag="JIX56_RS04015"
                     /old_locus_tag="JIX56_04015"
     CDS             20191..20931
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009328783.1"
                     /locus_tag="JIX56_RS04015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_04015"
                     /product="metallophosphoesterase"
                     /protein_id="WP_257537376.1"
                     /sec_met_domain="Metallophos_2 (E-value: 1.4e-06, bitscore:
                     27.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVAAVGDIHLGPDSRGLLRPAFETLPDHADLLLLAGDLTRHGT
                     PQEARVVAGEVAGLPVPVVAVLGNHDHHAERPDDVTAVLRDAGVTVLEGEGTAFDVDGV
                     RVGVAGTKGFGGGFAGRSGSEFGEPEMKAFVRHTRGLADGLRRALDALAEDGCAVRIAL
                     THFSPVPDTLVGEPLEIYPFLGSYLLAEAMDESGADLAVHGHAHLGTEHGITSGGVRVR
                     NVAQPVIRRAFAVYQLPVDGARAS"
     gene            21067..21498
                     /locus_tag="JIX56_RS04020"
                     /old_locus_tag="JIX56_04020"
     CDS             21067..21498
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009328761.1"
                     /locus_tag="JIX56_RS04020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_04020"
                     /product="hypothetical protein"
                     /protein_id="WP_257537377.1"
                     /transl_table=11
                     /translation="MPWRWRWRWGWGAAAGTVLLLTTGCGTVEERRTGALDAALDFERA
                     LGAGDGVAVCAVLAPAVREEIEQSAGASCEEGVLEEEVPSVTAASNDVEGIDVSGRQAR
                     VEFPTDTLFLSQFSGGWKVVAAGCGPQPERPYRCRLKGG"
     gene            21586..22272
                     /locus_tag="JIX56_RS04025"
                     /old_locus_tag="JIX56_04025"
     CDS             21586..22272
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009328779.1"
                     /locus_tag="JIX56_RS04025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIX56_04025"
                     /product="DUF6766 family protein"
                     /protein_id="WP_257537378.1"
                     /transl_table=11
                     /translation="MTRAVRRFLWENSLGLAFLTLFGLAVVGQAFAGRADFNNQLAAED
                     LQQVTLGEYMTSSDFAVDVMENWQSEYLQFFLYVFLTVWLVQRGSPESKSLHKSGVESD
                     EEQRVGPHASPESPRWAAAGGLRLKLYASSLGYVMGAVFVLSWLAQSITGVSAYNEERL
                     RQLQAPTSWPEYIVSADFWDRTLQNWQSEFLAIASMAILSIYLRQRGSPESKPVGSAHT
                     STGVEG"
ORIGIN
        1 cgttcgctcg cgggcggccc gtggttcctc atggagcact cgaccggtgc cgtcaactgg
       61 cagcccgtca accgtgccaa gctccccggg gaaatgcgcc gcaacgcgct cgcgcacgtg
      121 gcccacggcg ccgacggcat cgcgttcttc cagtggcggg cggcgagggc gggcgccgag
      181 cagtggcact cggcgatgct cccgcacgcc ggcaccgaca gccagatctg gcgcgacgtc
      241 gtccaactcg gcgccgaact acgggcgttg gccgaagtgc gggactccac cagcacggca
      301 caggtggcga tcgtgtggga ctgggacgcc cgctgggcac tggaactgcc ctcccagccc
      361 agcggcgaac tgcgctacca ggacttggta cgggactggt acacccccct gcggcgggcc
      421 ggggtcgccg tcgacttcgt acgccccgac gaccccggac tcgaccgcta caaactcgtc
      481 ctggcaccct cgatgtacct ggtcacggag gcggccgcgg cgaacctcac ccggttcacc
      541 gaacgcgggg gcactcttgc cgtcggcttc cacagcggca tggtcgacga gaactgccat
      601 gtgtacctgg gcggttaccc cggcgccttc cgcgatgtcc tcggcgtggt caccgacgag
      661 ctcttccccc tgctgccggg cgagacgacc ggcctgaccg gcgacgtggc gccgggagcc
      721 acggccgacc tgtggtcgga acgcgtccgg ctcaccggcg cacaggccgt cgcctcccac
      781 gccgacggcc cactggccgg ccaccccgcc gtcacccgcc accggcacgg cgacggcact
      841 gcctggtatc tggccacaca ccccgaccag gacacgctcg ccgccctgct cgaccgcatc
      901 cgtcaggacg ccggcgtcac accggagcac gacgcacccg ccgggatcga ggtcgtccgg
      961 cgccggggtg cggaagccga ctatctgttc ctcatcgacc acacgggaaa gggcgccgaa
     1021 gtgttcgccg aaggcgtcga actcctcacc ggcacgccgg tctccggcac tgtcagcgtc
     1081 ccaccgggag ccgtcgccgt catccgcgag ccacgctgac cagagcgcag gtcctgggcc
     1141 gccgacatcg cggtcgagta cgtcaggggg acgcggcggt ggtgacgccc tcgccaggga
     1201 gcgtgccgac gaaccgtggg cacgctgccg tggaacagtc agacgatccc cgcctgcccg
     1261 ccgtcgacca gggcttgtgt caccggtggt ccgggaccaa cacgatccgg cctcggagcc
     1321 cgccttcggc gagggcccgg tgggcatccg cgatctgctc cagggaatag gtcctggcca
     1381 cccgcaggct gatcagaccg gcgcccgcat aggccgccag cttggccagg cgcccggcgt
     1441 ccgtgtgcca cgccatattg atcatccgca cctggcggcg cgccatgggc gcggagttga
     1501 gcagcgacac gaacacaccg ccgtgccgca cggcgtccgc cgccccggcg gccaggttgg
     1561 ccgcgtcgac cgctccgtcc acgcccccag gcaccagtcg gcgcaccgtg ggcacaaggt
     1621 cgtcgtcgcg cgagacgaaa agccgtgcgc cggcctcccg cacgagcttc tcgtcggccg
     1681 gtccggcctg ggcgatcacg ttcagccccc gcagccgcgc aagctcgacc gtgaagagcc
     1741 ccaccccgcc ggcggcgccc gacaccagca gccactcccc cggctccagg gccaccttga
     1801 gtcccgtgcg caccatgacg tcggcgaagt tgaccgaagc cgcggccacc ttgaccagca
     1861 cctctccggg ccccggttcg ggggtcgcca cgtcgacgat ctcgatcgcc tcggggccgc
     1921 cggactccct gactactgct gcacgcatct gacctgtcct tctctccgcg cctcccgtgc
     1981 ggaagtcgca ggtccgacgt tggtccaccg atgagctgcg aggaaggtcc gctgttacct
     2041 gggtccagca gggccaggca ggtctgtggt cggcggcgta ccgtcggtgg ggtggagacg
     2101 actatcgggg agttcctgcg catccgacgc gagcgcatca cacccgaaca ggcggggctg
     2161 ccccccagcc tcacccggcg gcgggtaccg gggctgcgac gcgaggaggt cgccctgctc
     2221 gccggtgtca gcccggacca ctaccagcgc ctggagcagg ggcgtaccgc tcaggtctcc
     2281 gaccaggtgc tcgacgctgt cgcgcaggcg ctctccctct cggacgtgga gaccgagcac
     2341 cttcgcaacc tggctcgccc gcgtcgagcc gacgccgagg cgagagccac gcaacgggta
     2401 tcgagagcag tgcccgacga gccgctggtc cggctgctgg aggccatggg ggacgcgccc
     2461 gcgctgctgc tcggtactcg aactgggagg cgatcgccgc cgagacggtc gcccagttgc
     2521 gcctgctcac ggggcgccgg cccgacgacg ccaaactggc agcgctggtc ggtgagctgg
     2581 ccatccgcag cgagccgttc caacggctgt gggcgaccgg cgacgtacgg gagaagcggc
     2641 tgggcgtcgt ccgtgtcgtg cacccggtcg tcggcacgct cgagttcgac taccacatgc
     2701 tcaccgtgcc agcacgtccc gatcgctcac tgatcaccta cctgccccgg ctcggctcac
     2761 cgaccgccga ggccctcggg atgctgctga gctgggttgc cggccgaacc ggcccggccg
     2821 gtcgggaagt acccgccgca gcgccggagt ccgacggaga tgcgggcccg gcgaccgcct
     2881 gagcgtcctt ggaagagacg tcgatgtccg gactccgcgg gacagcgtga cgcgtcccgt
     2941 gtccggtggt gatccgccgc cggtggtcgc ggctctttcc ccaacgggcg gatgctcgtc
     3001 ggcgggaacc gctgtgggtc ccgccgacga gaggtcacga caccgtgggg atgatcagtt
     3061 gagggccggg gcgaggatcg ggtgcgtcgc gcggtgggtg atcttccagt gcccgctgtc
     3121 gagccggtag tggtcgttca gttcgacgat gtgtccggcg ttcgcggccg gatagagggc
     3181 ggggccctcg tcgacagggg tgggtccggc gtaggcaaga agggagacgg tgccctgggc
     3241 gctcccgtcc ccgatggtgt ggaagtgctg gttggtgacg aggtggcgga ccgtcacctc
     3301 gggaccggaa cgagcgtgga gcacgtccag gatctcggca tgaccgcgca gcttgcgccc
     3361 atggacctcg tacagggcgt cgggggcgaa gagttcgagc agctcgtcgt actcgcgacg
     3421 gtcgtagtgg tggaagaagg ccgtgttcag ccgggccagc gaccaggtcg tggtctcctc
     3481 gggtgtcatg ccttctcccc cttcggggtg atggtgtccg ggctggtgcg ggtcttgagg
     3541 acgaagtcga actccatgct ccggtagggg ccctggaaac cgtgtgcggc tatgtcctcg
     3601 gggtcctcgt gcagggcggt gtccgcctgc agggcggggt gggccagctt cgggccgacg
     3661 aagtcgacgg ggatgacggg gtctcccttg aagtagatct cgccgaacca gggggtgatc
     3721 aggtcggggt ggtggacctc gtagtggatg tgggccggac ggtagaggct gcggccgatg
     3781 gccgcggcgg cctcgacgac cctgtcgatc gccatggcgt aggcatcggc gtaggcgaca
     3841 ggggtgacgg tggtgaaggt gtagcggccg tcggcgtcgg tgaacaggtg cccgcgcagg
     3901 ttgtacttgg gcactccgtc gtcgtacaga ccggagtagt tgccgttgtt ggccgcgtgg
     3961 tagatctcca gcttggcgcc cgcgagcggc tgtccgtggc cgtccaggac gcggccggac
     4021 acgaccagcg gggtgccggg ctcgtccggc ctcatcggca gagtgccggg gttgtcgatc
     4081 cgtggggagc cggggatgac ggtggggctc ttgacgtcct cggagggggt gtagccgtcc
     4141 cggccgccct ggaagagctc gccgtagagc ggcatggcgg ccagcgccag ggggggcgcc
     4201 ggtggcctgc tgcatctgct gcagcacgtc ggtgacggcg ttgaggtcgt cgaaggtcag
     4261 tccttcctcg tcgcggaggc gggccagggc gtccttgaac gcctcgacga gtcgtaccgt
     4321 gcgggggttg atcagcgccg ggtcgacgta ggacggatcg gtggtcgtgg tcattccggt
     4381 ctgctccttc atggtggggg atcactgagg gcgggcatca ggcgcccggg gtgcgagggg
     4441 agtcggaggg gcacggctgc gaaacccggt ggcgacggtc ttcatggcgt ggtcttttcg
     4501 gacggcgggc ggttcggtgg cgaggacttc gacggattcg tcggattcgt cggatgtcgg
     4561 ccatggggtg accccgcaag gcccgcagac gcctcaccag aagtccaggc ccacctcgtc
     4621 ggcgagcttg atggcctcca gcacatcgcg gagggcctgg gcggtggggc cgcggctgcc
     4681 gtccgcacgg cgcggggtgt tgccgaagga gtagacgccg agttcgaagg tcatggcggg
     4741 ccggtcctga gtcagttgct gatggcgggc atggcccgcc ggtagcgggc gtcggtgagc
     4801 tggaggacga ggaacgctcg ggaagccctc cgggccgccg tcaccgatcc agacgttgat
     4861 cgccacgtgt gcggcgtgca caccgctgcc ggccagttcg ttggccaggt tattgaccca
     4921 gttgcgcagg gcggcgccgg cggcgttgac gttgccgagc atgggaacga gatccaccga
     4981 accgccgccg gtggtgaaca gcagggtgcc gacgcccgcc tcgcgcatcg cgggcagcac
     5041 cgcgtgggtc gcggcgacgg cgccgtagaa gacatactcg atctgcggct gcagattgcc
     5101 cacagtggcc tcggaggggg cgaccatggt gaggccgggc accggggagt gcggccgggg
     5161 agtactccag tacgtcgatg ccgccgaaaa gggccttggc cgcgtccaga gcatccgtca
     5221 gtgaggcgcg gtccagcacg tcggcgggga acgcggcggc cgtgatgcct tcctggccga
     5281 gctggtcgac gagcgtctgc agcttcttcc ttggtgcggg agatcagggc gccgtcgaag
     5341 ccgcggctgc cgacggtgcg ggcgatggcc aggcccattc cggggcctgc gccgacgatg
     5401 gcggtagtgg gcacgatggc tttgtcttcc gtgaagaggg gccggtttca ggcgcaggtg
     5461 acggcgatct tgcccggggt actggcgccg aaggcggcga aagcctccgg ggcctgctcc
     5521 agcgagtagg tggccgtgac cggcacacgc agtgcgccgg aggcgacctg ctcggccagg
     5581 gaagtcagga tctgggcgcc aggggtggcc atgatcgcgt ggacggtgac ttcctgcccc
     5641 ttgacgtcgt cctgggacag gccggtagcg gaggcgagct gtccgcccgg ccgcagcaga
     5701 gcggccggcg ccgggccgtc gcccgccagg tgcagcaccg cgtccacacc gtccggggcg
     5761 atcgcgcgga cctgtccctc caggtcaccg gtgaagtcga ccacgtgcac ctccgcgccg
     5821 gtgaggccgg cgacgaagtc ggcctgggcg ccgggacggg cagtcgccac caccttcgca
     5881 ccgcggcttg cggcgagttg caccgccagc gcgcccaccc cgccggaggc cccggagacc
     5941 agcaccgtct cgccctcgga cagggccacc gcgtccaggc tcacctgggc ggtggccccg
     6001 gccacgccca gcgcgcccgc gtcccccacc gtcaggccga cgggaatgtg ggcgacgccg
     6061 tgtccggcgg gcacggtgac gtactgggcc agcgacccgg cgcccaggaa cggcttcagc
     6121 acgacaccga agaccgcgtc gccgaccgcg aagccgtaca cgccctcgcc gagttcctcg
     6181 acggtgcccg cgaagtcctg gccgaggacc agggggaagc ggtgctccat gaacgcctgc
     6241 gtgtagccgg cggcggtggc gaggtcgaag ccgttcaagg aggcggcggc caccttgacc
     6301 aacaattccc cggcttttgg acgaggggtc tccacctcgg ccacggccgg gggcgagggg
     6361 acggaatcga gtgttgcagc acgcatgaca gcactcctga ttaagtggac cggtcggccc
     6421 actttcactg tctcccaccg tacaacagaa ccggcccacc cgttccagtt gagtagagtg
     6481 ggagcatgac ctccccgcct tccgatcaga cgccgagccg gcagcccggc acgggactgc
     6541 gcgccgacgc cgagcgcaac cgcgaccgca tcctggccgc cgcccgccgc ctctacgcca
     6601 ccgaaggact cggcgtctcc atgacctcgg tcgcccggga ggcaggggtc ggcaaagcca
     6661 ccctctcccg ccgcttcgcc acccgggagg aactcgtcaa cgcggtcttc gccgaccgca
     6721 tggacgccta cgccgacgcc gtcaccgccg ccctggacga ccccgacccc tggcacggct
     6781 tcaccggcta catcaccgct gtctgcgcca tgcaggccgc cgaccgcggc ttcgccgacg
     6841 tgctgaccat gaccttcccc accgccaaag cgctggaggc ccgtcgcgcc gaggcctacc
     6901 agagcctcct cgaactcatc gcccacgcca aggacaccgg gcacctgcgc gacgacttca
     6961 cccaccagga tgtggtcatc ctgctcatgg ccaacgccgg cgtcatcgcc gccaccggcg
     7021 acgccgcccc cgacacctgg cgccgcctcg tcggccacat gctccgctcc tacgccgcgc
     7081 ccggggcccc gatccccgcc ctgcccgaag caccggcgcc caccgtcctg taccgggcca
     7141 tggtccgcct ctcacgaacc gggccggccg ccacctaggg tggcggcctt ggctcgtcta
     7201 cggcgccatc gtgtgcgggg aaccggttgc ggggctctcg ctgcggtgca gcgacggccg
     7261 gaaccctcgg agtgggccac tcgacaagat gtcggcggcc ccggtcacgg cgagtccctg
     7321 gccggcgacc cggtcgacgg tccgccgagg cgcccaagcg tcgtccccgg gagtgcggcg
     7381 gtcgcgagca cgggcggctt gcgccacagg acctccgggg tcgggaccgg cgcgagggac
     7441 atcgcctcga cctcgacgtc gatgcgcgcc tgatcgacgt ccaccttcag gaacatgccg
     7501 ccgacgcgca gagtcgcccg ctcggaatgg gcgacgacga ctttgacctc atccatgggc
     7561 gaccagtatc ccggggatga tcgccggcgt cgccgggttt atcgcgtgcg attacgcggc
     7621 tgaccgcgtc cccctaccca gcggcctcgt gcacggcacc gacctctgac caggtcaagc
     7681 ccaccacttt tgttaggagt cccaacgcca gtacccggtg cgaaggttcg gagttcttcc
     7741 tccagcatcc gttcgggaga gtagctcagc gggaagagcg ccgctacctg cgtggcggag
     7801 gtcgcgggct cgaatcccgc ctcgcgatcg ccggaccgat cttgaatttc gggcgtatct
     7861 tcatttcggc gaatcgtcag gtcttgcgca cggcgccggt gaagccggcg acgaacaggg
     7921 tggccaacgc ccacgcggcc agctgcagca gccagcccgc gacggtgagg gtctgccctg
     7981 caggggtgcc ggtggtcaag acgggggcgc acaggtcccg cgcccccgtc ttgaccaccg
     8041 gcagacccag atccaaaccc acgccgaccc gctccacgac gctgcagggc gtcgtgggtg
     8101 tgctcgcgcg ggcggtgtgc cccaggccgc ccggcccgcc gaggacgacc gccagcgcga
     8161 ccgagccggc gaggacggcg aacaacagca gcagcgctcg ccagggttga taaccgaagc
     8221 cgagggccag cccggtgaat cgggcccagg cccggtcacg ccgccgaagc ccgccacggt
     8281 cgatctggtc ccgccgctgc gccatgagaa tgtcccgcac ctcgctgtcg tgaccggccg
     8341 cccggtggac ggcggccaac tgctggtacg gctgagcgga gtagccgggc gtgtggtcac
     8401 gcaacagctc cagccaccgg gacaacccga ccggcgccgg caggtccgcg taggtcagcc
     8461 cgtcgatgcc gaccagggcc cccgtggcct gacccgaccg agtcaccccg ctggtgtcca
     8521 aaaacagcga accttcaccc gacaggccgt tcaaggcgag cacggcgtgt ccggcgccgg
     8581 ttgcccggaa cccggcgcgg aggaacacgc tgtgatcgac ccgcagaccg tcggcgtgca
     8641 gggcgggacc ggacgtgttc gccagccgcg caccgtcgca atccagcaga ccgaggtggg
     8701 cgccgaggaa ccggaccgcg ccggaaggtg tgtcggcggt ggcaaccgct ccgcgcatcg
     8761 tcatcaccgg cgcggtgaag cgtgcggcgt caaccggtgg gtcgtgcgaa cccgcggggt
     8821 gcatgaacag cgcctggcgc accgtcagca gttcctcgcc aggagccgcc tcgtgctgtc
     8881 cgcccctcag ttgcatgcgc tctatctcca aggcccggtc cccgatgagg aattgcccct
     8941 tggtctgctg ctgtacgacg tcccgcagtt cggccacgat ctgctcgtag cgctgccggc
     9001 tgacgctccc gactttgtcc gtgacagccg tcatcgtggc caccacccct cgcggtcggg
     9061 gcccggcgga ccggaccgcc ggtgacacac cccggccctg ccatcagcag cagcgcaccc
     9121 gacagatcga ccaccggtag tgacgggaac tgagcgaaac tgggcgaaca gcgccgcaat
     9181 tggggccttt tcgccgttcg ttcaagcgtc agctggacgc ttgaacgaac gcttccctcc
     9241 ggtggtgcca ggccctcttc cggcactgcg gcgagcagta caccgcatcg ctgcggtggt
     9301 ccaccccggc cacccaggcc tccccgcact ccgggcagac acgccggccc tcgccccgct
     9361 ccaacgcggc cacccgccgc cgaagccgac gtacccggcg ccactgcctg gaccgacaca
     9421 cccccgagca gtgcaccgcc cgaggcgcgg cctccggcac cagccgcgaa ccgcacccgg
     9481 gacaacgccg ctctcccacc ggcccgttga ccccggccac ccagccagcc tagaccccct
     9541 caaagatcca gaagaggggt tcagaaacgg gcactgaaga ccgcccccat cccacgggcg
     9601 agctgtcgag ccacgtatca agccttccga gcagggcgtc gggcggggca gccgacacct
     9661 gccgcgggtg cacgtcagca agccggaagc cgtccggcct gatgctgacc gtttgctgac
     9721 ctggaggcgg agatcagcgc tctgacccgc ggaaacaccc aaacgctaga tcttggactt
     9781 gaacatgcta cgcagcatgg aggcgctccc ggacctaggc tccctgcctg cgtttttgca
     9841 ggtcaagggc tgtttccata ccttacgacg agtcgcatgt ccggtcagca tgcgcgggag
     9901 gcttttgagg gctcgtgcgg cagaccggcg gcgcacggcc cctgtcagcg gcggcggcga
     9961 acccggccgc cgccgctgaa caccagggtc gagcgtgctg tcagccggtc accggctgca
    10021 gtttggcgcg gaagtgccga agaatcgggg actggtccac gattctgtag ccccggacgg
    10081 attccgcgcc tttggcgatc cgttccaggg tcctgccgac gtggtcgtag tgactgcggg
    10141 tgtagacccg gcgcgggagc gccagcctga ccagttcgta cggcgcgctc ttggtggggt
    10201 tgccgtcctc gtcctcctcg ccgaggtaga gggaaccgag ttcggccgag cggatgccgc
    10261 cttcgaggta gaggcggcag gcgagggcgt ggcccgggta atggtggggc ggtatgtggg
    10321 gaagcaatcg tccggcgttg aggtacaagg catgcagccc cgggggttcg aggatgtcga
    10381 cgcccgccgc gcggacccgg tcggcgagat gggaggcgac gtcggcccgc tccgcgaggt
    10441 acgcgggctc ggtcacctcc agcaggccgg tggccatcat gtcgaggtcg cgtcccgcga
    10501 gaccgccgta cgtggcgaag ccctcggtgg cgatgaggag ccgttcgcac ttctcggcga
    10561 gttccgggtc gttgaggccg atgaagccgc cgatgtggac gatgccgtcc ttcttggcac
    10621 tcatcacaca gccgtcggcc agccggaacg cttcctcggc gacctggcgc ggggtacggc
    10681 cgcggtatgc ctcctcgtgg cgggtcacca gccaggcgtt ctcggcgaac ctggcggcgt
    10741 cgaggatcat cgggacgccg tgccggcggc agatctcggc ggtctgcttc aggttctcca
    10801 tggagaccgg ctggccgccg cccccgttgt tggtgatcgt catgatcacc acgcggacgc
    10861 gggagccgtc cggaccctcc agcgtgcgcc ggagtacggc caggtcgatg ttgcccttga
    10921 aggggtgggc actgtcgagg tcgcgggcct cggcgcacgg aatgtcatgc gcctgacatc
    10981 cagcaagttg gacgttggcc cgggtcgtgt cgaagtgggt gttggacagg acgatgccgc
    11041 cgggttcgag gagcgtcgtg aagaggatgc gttccgcggc gcgcccctgg tgggccggca
    11101 ggatgtgttt gtagccggtc agctccgtca cggtctcgtg gaagcgatag aaggagcgcg
    11161 aacccgcgta ggactcgtcg ccctccatgc ccgccgcgag ttgcgcggcc gagatggcgc
    11221 cggtgcccga gtcgctgagc agatcgatgg tcacctcctc ggcgcgcagg tcgaagaggt
    11281 tgtagtgcac ccgctccagc gccgcttcgc gctgttgccg agtggtgagc gcgatgggct
    11341 cgacgacttt gatgcggtag ggctccatgc cggtccttgc tcctgacgtg ctgcgggttg
    11401 ccgcgtggtt gatgtgtcgg cgactgggct catgccgtcc ggatgacggc gtgccgtagc
    11461 ccgacggcgg ggtgttcggc ggccggacct cgtaggcctc cgatgagagg tacgtggtca
    11521 cccggggtgg ctgatcctgc tcatgggcca gcgccacgta cgcgatgagc ccggcaccgt
    11581 cctgcggccg ccgcggggtg atggcgccca gcgaccgggc gagcgcgccg gtgtccagcc
    11641 cgtggcgacc gaggacggcc ccagcccgct ggagtgcctc cgcgtcgtcc cggacgtagt
    11701 ccctgatcgg gacatgcagg gtgaagccgg tggggccacc ggtcgtcctc gtgaaggaat
    11761 ggcaggtaag gacggggcgc ctgtcgaacg tggccctcag ggccgacggg tgttgcgttc
    11821 cgtcgtcgaa tccgcccgcc gtgcggagga actcctccag cgtctggttg tcggggccgg
    11881 attccatccg gcacagacca ccggcggctg tggtcggcag tccgtgatga gtggcgtaga
    11941 tcttcactcg gggcgccgcc cagtcgccca ggtcgagcgc gaagaacggg tagccgtcgg
    12001 ccggcggcag cgcgtcgaag gcgtgccggt ggcccagccg gtccagtgct tcccgtaacg
    12061 tctcggcggc ccgcgtcgcg ccggccgccg ctgggttcag gtagaccttg gccttgggta
    12121 caccgccggg gcgcagctcc agcgcgatcc acagcgccag ggggccctga gggtccgtgg
    12181 gtaagaacag gtcctccagc acgtcgagtt gatcggtggc gaaggcccag cgccgcgcca
    12241 tcgaccggac gacgcgcagt ccggcgcggc cgttgtccct caggctgtcg gcatcgcatc
    12301 ccggttccag cagcacacgc accgtcggcg gcgcgtccgg tgtgaaggag agcgagaact
    12361 ccaccggcgt ggagtcgtcg gacaggaaag tgcgggaggg gggcggcagg tccaggggcc
    12421 gttcggccac cgctcccagc gagtcgttca gtacgtgcgc gtatgtctcg gcgtcggatc
    12481 gtccgagccc cgacacctgg cacaaccgca gcaactggcc cgtcacgagc ccgccgagcg
    12541 tccggtcact cccggtgctc ccggtgccgg acccgatggc gctcaccggt gctcccgccg
    12601 ctgctcggag tgcgggggtg gggcttgtgt cccgtggatg ggggtgcgag gggacacaga
    12661 aagatacccg ccgacctggg cgggtatctc gtctcgcggc gactggtggc ggggcacgcc
    12721 cctcgcagtc tccgcgtggt gtaacgcggt ctgtcgtcgg gagcgggaaa tgtcaggatg
    12781 tcgagcagaa gcggcgccgg tggacacgta ttccacgaca cctccctttg ttcattggtc
    12841 accacgaatg tcgccgcgtt actacccctt tggttgaata ctcatgcagt gcgttctgtt
    12901 acaggctgtt gcgtgcgtca ccccttcaac caggacagga aggagcccca cacacctcgc
    12961 tccgttttcc gggccgccgg ggtgttctcg ccgagtgcgg gcgcctgcgt cgcttgcggg
    13021 gggttgggcc gctccaccac ctgcggggtg aagcggcagg gcagcgcggc caaggcgcgg
    13081 tggaaggggc ccggacgcca ggtcaggctg tcctcgggca ccgcgagttc gatgtcgtgc
    13141 agccggttga gcaggttctc gatggccacc atggtgacga gccgcgcgag ttccttcgag
    13201 gggcaggcgt gcgggccggc gctccatgac aagtgggctc gcctgccgcc ggtctggcgg
    13261 gcggcggcga gcgccgggtc ggtgttggcg gccgtcatgc tgacgaggac cagatcgccc
    13321 gcccgcagct tcgtcccgcc gaactccatg tcggccgcgg ggtagtgcgg cgcgtagttc
    13381 gccatgggcg ggttctccca cagcgtgtcg tcgatggcct cctcgatcag gccaccgtcg
    13441 gcgtaccggt cgtggagaag caaccggtgc aacgtgttgc cgatgaggtt gcgcagcggt
    13501 tcggcgcccg cgcccaggag caggatcaac tggtggacca gctcttcgtc ggtcagccgc
    13561 gcctggtgtc gcatcaggta cgaggtgacg tcgtcggccg gcctggcccg cttgagcgcc
    13621 accagttcga acacggcctg ccccagcact tcgttcgcct tctcggcgtt gacgccttcg
    13681 aagactccgg atatgccgaa gacgaccctg tcaccgatgt ccgccgggca gccgaagagc
    13741 tcgttgaaca cgaggagcgg cagctgcttg acgtagtcgt tcatcaggtc gaccgaaccg
    13801 cgggaggcga cctgggccat gaggtagtcg gaggcccgct tggtcatgtc gctcagtcgg
    13861 cgggagtcca ccttggcgag gctgtcggtg accgcctgac gcagtcgcgc gtgctcggcg
    13921 ccgtcggtga acatgcagtt gggccggtac cccagcatcg gcacgaccgg gctgtccggg
    13981 ccgaccttgc cttcggcgac gtctcgccaa cggcgtgcgt ccttgcggaa gttgccggga
    14041 tcctggagca gtttcagcgc cgtcgcgtgg tccgtgacga gggtcgcgtc cacgccggga
    14101 gcgatctcga ccggcgcggt cggcccgtag tgccgcatgt gcgcgtagta cgcctgcgga
    14161 tccgccgcga aatccggccc gtacaacgga acgcgctgtc cgctgtcgtg ggccgggcag
    14221 ccgggtggcg gtgcggggaa ggtggaatcg gaggtcatgt ctgctctgct cctaacgggc
    14281 gcggtccatc aagtagcgga cgagcgtgat cagtgcttcg gccgacgacc tctcgtcccg
    14341 cgcgtcgcag gtgacgatag gggtgtcgtc gagcagatcc agcgcttcgc gcagcgccct
    14401 tgcgtcacgt atcgacgtac cgtcgaaatg gttgaccgcg atcgcgtagt cgagtccgta
    14461 ctgctcgatc aggtcgatca cggcgaatga gtcggccagc ctctcggggt cgaccagcac
    14521 gagcgccccg agggcgccgc gggccatgtc ctcccacatc tgcacgaagc gaagctggcc
    14581 gggggtgccg aagagataca gcacgacgcg gtcgctgacg gtgagacggc cgaagtccat
    14641 ggcgaccgtg gtggtggtct tgccctggac gcccttgagg tcgtcgatcg cctcgcccgc
    14701 ctgggtcatc gtctcctcgg tggagagcgg cgagatctcg gagatcgacc cgatgaacgt
    14761 ggtcttgccc accgcgaagt gcccgacgac caggatcttc acggcggtct gcgtctcgcc
    14821 gtccgggacg tacgcccgct catccaaact tggactggag accattgagc acctcctcga
    14881 gaatctgcag gttggcgacg ggagcacgcg gaaccggcgg gcgggtgacg aggtagccgg
    14941 cctcggacag cgcggccagc aggattttca ccacccccac cggcaattgg gtgtgccccg
    15001 cgatctcggc gacggagagg taaccgccga cacacatact cagcaggtcc tgctcctcgg
    15061 gcgagaggcg cgccggccgc tgctgctggt cggcgaccgc cgtgaccagt gtgatcaggg
    15121 aaaactggct ctcaccggga agactgcggc caccggtgat gacatacggc cgtactaact
    15181 cggcagcctc gggctcctgc ttgtcggaat cggtcatggc cgtatcacgc tgctctcccg
    15241 gggtggagcg gtcatgacct tgcccaactg gccgacgagt tgctgcatgc ggaaggtgat
    15301 gtccgccatg tcgatgtcgg aggaggccga cacggcgagg taggcaccgt caccggccga
    15361 gatcaggaag atccagccgc cgtcgaactc gacgagtgtc tgctgccacc gcagatccga
    15421 ccgggagcag aagaacgcca gcgatcggct gagcgactgc atgccgctca tcgcggcggc
    15481 tgccttgtcg gcgtcgtcct tgtccactcc cttcgaacgg gccctcagca acccgtcgga
    15541 ggagaccaga accgcgtgga gagctccggg gatctccaag gcgctgtcaa gcatccaaga
    15601 aagatcgttg ttcattcggc ctcgtgccct tcgctgcttg cgtcacgggt gctgctcgga
    15661 cgctcacccg cctgcggatg tgtggcgcgg cccgcgtccg tgccctgctt gaaggcggcc
    15721 atgatcgctg ccgtgtcctc actgcggcgc ctcgtggccg gtgaggcggg cgagtcggtc
    15781 gagaccaggg ccatcggccg cttgcgccgc cgcttgggca ggccgtcctc ggtcgtggcg
    15841 atgggcagcg agggctcggg gtcggtctcg tacaccgagg gacgttcctc ggcgggcggc
    15901 ggcggcacct ctttcggcgc caccgagtcc accggcaccg tcggctgcct cggctccggc
    15961 atgctggtca gcagctcgtc gggcagcagc acgaccgccc gcacacctcc gtagggggag
    16021 gtggagtcca ccgacaccgt gaagccgaag cgctcgcaga ggacaccgat caccgcgaag
    16081 ccgaactgcg gagggttgcc cagccccgag acgcccgtga cccgctcgct cgtcaggagc
    16141 ctctcggccc tggccttctc ttcctcgttc ataccgacac cggcgtcatc gacgacgatg
    16201 cagacaccct tgggcacgga gcggacgttg atctccacca cggtgtccgg gctggagtaa
    16261 ctggtcgcgt tgtcgagcaa ctcggcgagc gccagcgcca ccggttcgac ggcccggctg
    16321 gtgataccga agtcgacctt cgacaggatc tgcgcccgct ggaaatgccg gatcctgccc
    16381 tgggcactgc ggaccacgtc gtacaccgag gccgtgtcgc ggtgccggcc gagccagccc
    16441 tcgcacaaca cggcgatgga ctgggcacgt cgaccgaact gcgcgttcat gtggtcgatc
    16501 tccaggaggt cctggagcat gacggagtcg ccgtacttcc gctgcagccc ggaaatgatg
    16561 cgctgctgct cggcggcgag accctgcagt gtccgcatgg cggacttcag ggccgtcctc
    16621 gtttctccct cggcttcctg ttgggccgca cggacggact ccgagtattg gctctccaac
    16681 tcaccgtagt gctttctgag ccctgcgatc tcctgtcgta atgtccgcgc cgcccgtcgc
    16741 tgacgaacaa tcagggcgac ggcggcaagg gtcacgacaa cgagtgccca gagtgccgga
    16801 ttttgtatgt attgcgtcat gagaccttct tcaggcggct gatagccagc tactgaattc
    16861 ccgtcaattc acacagaccg aaggctcagc cactccgggg ttgccaccca ggcctccacc
    16921 aatggcgaga gatgctcctt ttgcacccat ccgtccgttc ggtaagtgcg gtgatcgtat
    16981 caccactccg ggtggtgacg ggtcgtcaat ctgcggagta cttgcgaagg ttgagcccta
    17041 cggcaagcag ccgcgcacgt ggggcgaggc cggctggagg cgtcgccctc ggcggcgata
    17101 cggaatcgac tccggccggc agcggttggt gcctgactgc cagggccagc cggtcgggaa
    17161 gcgcccggtg cgcagcacca tgtactcgtt caccgaccac aggtcaggcc gccgctggcg
    17221 attcggccca tcgcgcgatg tgcctcccgg actccatgat gggaagcaag cggaatctat
    17281 tgcaggacga caaggcgagg cggtgtgccg acgaaccgcc gtatcaacac cacggaggct
    17341 gtcatggcac tcaaggaacc cggtcccgtc aacagacgtc agttcctgtt ccggtgcgga
    17401 gcggggaccg tagcactcgt ggcgggcttc gatctgcttg cccggcagtg ggtgacggag
    17461 gccgcagccg cggaaagtgc ctcgttcgcc acagcgccac ctctcgacgg caccctcaca
    17521 ttcgacgcgg aatccatcgc ggcgaattcg cacgaccagg gcaacatcgt gttccggaca
    17581 ccgtgcgcgg tgctccggcc aggttcggtc caggacatcc ggaagatggt cggcttctgc
    17641 gccgaccacg acatcacggt cgcaccggcc ggcacgcatc acgcgatgtt cggtcaacca
    17701 ctcgtgagcg gtggcctgat catcgaaatg caatcactga acacgatcca ctcgatcggc
    17761 acggacggcg ccgacgtcga tgccggcgtg ctgtggaagg acgtgatcga ggccgcgtac
    17821 gagcagggtc tcacgccggc gtcgatcacc agctacatca ggacgacagt cggcgggacc
    17881 ctgtccatgg gcggcatcgg gatgatgtcg gcctatcggg ccggcgcgca ggtcgatcac
    17941 gcccagcaac tccaggtggt cactggcgag ggtcggctga agtggtgctc gggcacgcag
    18001 aacagcgacc tgttcgaggc ggcactcgcc ggactgggcc agtgtggcgt gatcacgcga
    18061 gcgaccatcg acctggtgcc cgccaagcgg ctggctcgga cgtaccggat cgagtactcg
    18121 gacataccga ccttcttcca ggacatccgc gtccttgcga accggggcga gttcgactcg
    18181 ctcggcagca ttccccagcc aggcacggcg cagccgctga cgctgtgggc caccgtcttc
    18241 cacaaccctg gcgacgtgcc cgacgcgtcc catctgctcc gtgggctcag ctcggccgcg
    18301 gacgcggcgg ccttcgagga ctacccctat ctcgactaca tctccttggt caccaccatg
    18361 tacgacgcgt tcgcggcgaa cctggactgg gacgcgaaag tcaagccctg gtcggacctg
    18421 ttccttccgg acggcgccgt ggagcagtac gtcgagtcgg tgttcccgtc gttgaccgcc
    18481 gaggacctgg ggccgaccgg tttcgggctg atcttcccga tgctgcgttc gagctacggc
    18541 cgaccgctgc tgcgactccc cgacgaggca ggcggcccct gggtctggct ggtcagcgtg
    18601 ctgaccgatt cagcggagtc cggccccgat cctgagttcg cgtcacggat gatggaccgc
    18661 aactatcgct tctaccagga ggcggctgcc ctcggcggcg tgcgctaccc gcacggcgca
    18721 tgcgcgttca cgcaagccga ctggcaagcg cactacggct cgatgtgggc gcagttcctc
    18781 tcgtggaaga atcactacga cccgagcggc atcctcactc ccggcccgag catcttctga
    18841 cctggctcgc cgacggtact ccaccgcgcc ctacgtcgcc gctcggcctc ctcgatgagc
    18901 aacgcggacc tcgccctccc ggaccgcgtc agccggtccc cgagcagcgg tctttcccct
    18961 ggcgcttcgc ggtgtgccgc atgcgacgga cgtatcggca tgacaccgcc ggggggcgag
    19021 gacgcccgtg accggctcgg tcacgtggac ccgtgctcgt acgggcatgc gacgacgtcc
    19081 cgcagtcccc gtccggcgcc tggtcggccg gtccggcgcc cctcaccgcg cagggcgaca
    19141 tccaggacag gggttccggc cgggaggacg ttcgtccagg gcactgtccg gttcagctgt
    19201 tcgcctactc tgtgagtggg gctcactgtg agctgcgttg cacatctggc catcggctgg
    19261 agccgcacta tcgtggaagg catgggcgat ctcgccggcc cggacgacga cgggctccct
    19321 cccgaccgga cccaggccat cctcgaagcg gccaaagagg tcgcttcgct gctcaaggcc
    19381 ggtgggcact ccttcgcgct ggcgggcggt gtcgccgtgt acgcgcacgg cggcccgggg
    19441 acgctccagc acgacgtcga cttctgtgtg ctgccggagg acatcgacgc cgtcaccgtc
    19501 acgctggagg ccgcggggct gaaggtggtc gagccgcccg aggactggct gctgaagacc
    19561 cgcagccagg ggcaggacgt cgatctgatc ttccggccgt cccagagacc ggtcagccgc
    19621 gaactgctgg accgggcgga gatgctctcg gtcgaatccg tgtggatgcc cgtgctggcg
    19681 ccgacggatc tgctcatcgg gcgcctcatg gcgttctccg agcactactg cgacttcggt
    19741 gccgtgctgc ccatcgcccg caccctgcgc gagaagatcg actggagtcg ggtacggcgc
    19801 gaatgcggcg ccgagccgat gccggacgcc ttcctctatc tgctggaacg cctcaatgtg
    19861 atcgagccgg aggagaccgg cgatggcgac aggacatgac aacccaccgg tgagcgggcc
    19921 cggggacggt gccgcccacc cggcggcgca caccgagtac cgcatagccc acctcgagga
    19981 gcggctcgcc cggagcgatc tggccgagct ggggatgcgg atcgaggccc gcggcgacgc
    20041 cgtgcacatc acgggtacgg cgtccacggt ggccgatcgc gagacgatcc tgcggatcgc
    20101 ggcggcggag ctgccgggcg tggccgtacg ggcggacatc acgttggccg atgtcaccgc
    20161 cccggacccg gaccgttcgg aggagctgtc gtgatccggg tcgcggcggt cggggacatc
    20221 catctgggac cggacagccg aggtctgctc cgcccggcgt tcgagacgct gcccgaccac
    20281 gccgatctcc tgttgctcgc cggggacctc acccgccacg gcacaccgca ggaggcgcgg
    20341 gtcgtggccg gcgaggtggc ggggctgccg gtgccggtcg tcgccgtact cggcaaccac
    20401 gaccaccacg ccgagcggcc cgacgacgtg acggccgtgt tgcgggacgc gggcgtgacc
    20461 gtgctggagg gcgagggaac cgccttcgac gtcgacgggg tacgggtcgg ggttgccggg
    20521 acgaaggggt tcggcggcgg cttcgccggg cgcagcggca gcgagttcgg cgaacccgag
    20581 atgaaggcct tcgtccgcca cacccggggt ctcgcggacg gtctgcgccg cgccctcgac
    20641 gcgttggcgg aggacggctg cgcggtccgt atcgcgctca cccacttctc gcccgtgccg
    20701 gacacactcg tcggtgagcc gctggagatc taccccttcc tcggcagcta tctgctggcc
    20761 gaggcgatgg acgagtccgg cgccgacctc gccgtccacg gccacgccca tctgggcacc
    20821 gagcacggca tcacgagcgg cggtgtacgg gtgcgcaatg tcgcccagcc ggtcatccgg
    20881 cgcgccttcg cggtgtacca gttgccggtg gacggggccc gcgcctcgta aggccgcacg
    20941 ccccaggggt cgttgcccca gccgggggac ggcgtgtccg tgcccgtcgc gctgcccggg
    21001 ccggaccgcg aggccgcgct accgtccgtc gacacatccg tcgacagccg aacgggaggt
    21061 cctgggatgc cctggcgatg gcgatggcga tggggatggg gagccgcggc gggaaccgtc
    21121 ctgctgctga cgaccggctg cgggacggtc gaggagcggc gcacgggggc cctggacgcg
    21181 gccctcgact tcgagcgggc gctgggcgcg ggggacggcg tcgccgtctg tgccgtgctg
    21241 gcaccggccg tccgggagga gatcgagcag tccgccgggg cgtcgtgcga ggaaggtgtt
    21301 ctggaagagg aggttccgtc cgtcaccgcg gcctcgaacg acgtcgaggg catcgacgtc
    21361 agcggacgcc aggcccgggt ggagttcccg acggacaccc tgttcctgtc tcagttctcc
    21421 gggggctgga aggtcgtcgc cgccgggtgc ggcccgcagc cggagcggcc ctaccggtgt
    21481 cggctgaagg gcgggtgagg acgtcgtgcg cgtcatgttc gccctgtgcc tgctggtgat
    21541 cgcgggtggt ctggcctact gcatcacgct gggcgtgctg caccggtgac tcgggccgtg
    21601 cggcggttcc tgtgggagaa cagtctgggg ctcgcctttc tgacgctgtt cgggctcgcc
    21661 gtggtcggcc aggccttcgc cggtcgcgcc gacttcaaca accagctcgc ggcggaggac
    21721 ctccagcagg tcactctcgg cgagtacatg acgtcctcgg acttcgccgt cgacgtcatg
    21781 gagaactggc agtccgagta cctgcagttc ttcctgtacg tcttcctcac ggtctggctg
    21841 gtgcagcgcg gttcaccgga gtccaagagc ctgcacaaga gcggtgtcga gtccgacgag
    21901 gagcagcgcg tggggccgca cgcgagtccg gagtcccccc gctgggcggc ggccggcggc
    21961 ctccgcctca agctgtacgc cagttcgctc ggctatgtca tgggagccgt cttcgtgctg
    22021 tcctggctcg cccagtcgat caccggtgtg tccgcgtaca acgaggagcg gctgaggcag
    22081 cttcaggcgc ccacgagctg gcccgagtac atcgtctcgg ccgacttctg ggaccgtaca
    22141 ctgcagaact ggcagtcgga gttcctcgcc atcgcctcca tggcgatcct ctcgatctat
    22201 ctgcgtcagc gcggttcccc ggagtccaag ccggtcgggt ccgcccacac gtcgacgggc
    22261 gtcgagggct gaaccacggg gaaccgcacg gctcctacgc ggcggcgacc ggcgactccg
    22321 cgaccggccg gtcggcctcc gccgccgact tgtcgaactg cgtccggtac agctccgcgt
    22381 accgtccgcc gaccgccagc agctcctcgt gcgtgccgcg ttccacgatc cggccggcct
    22441 cgacgacgag gatctggtcg gcggtccgta cggtcgacag acggtgggcg atgaccacgg
    22501 cggtcctgcc ctccagcgcc tcggcgaggg cctcctggac ggctgcctcc gaggtgttgt
    22561 cgaggtgggc ggtggcctcg tcgagg
//
