LOCUS       NZ_CP102509            21080 bp    DNA     linear   CON 06-JAN-2024
DEFINITION  Streptomyces sp. NBC_00162 chromosome, complete genome.
ACCESSION   NZ_CP102509
VERSION     NZ_CP102509.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NBC_00162
  ORGANISM  Streptomyces sp. NBC_00162
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8635149)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Joergensen,T.S., Klitgaard,A.,
            Mourched,A.-S., Blin,K., Larsen,T.O., Weber,T., Gotfredsen,C.H. and
            Charusanti,P.
  TITLE     Identification of the biosynthetic gene cluster for pyracrimycin A
            and elucidation of a key reaction during its biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8635149)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/05/2024 18:03:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,275
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,805
            CDSs (with protein)               :: 7,805
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 371
            CDSs (without protein)            :: 370
            Pseudo Genes (ambiguous residues) :: 0 of 371
            Pseudo Genes (frameshifted)       :: 186 of 371
            Pseudo Genes (incomplete)         :: 231 of 371
            Pseudo Genes (internal stop)      :: 27 of 371
            Pseudo Genes (multiple problems)  :: 68 of 371
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:41:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8482065
            Orig. end                         :: 8503145
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21080
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="35"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21080
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21080
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11080](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11080)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(340..350)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(377..862)
                     /locus_tag="JIW86_RS39245"
                     /old_locus_tag="JIW86_39245"
     CDS             complement(377..862)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013752.4"
                     /locus_tag="JIW86_RS39245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39245"
                     /product="transposase family protein"
                     /protein_id="WP_257559062.1"
                     /transl_table=11
                     /translation="MQVGERALHDPALLAQTRTVLKHHSHGLHFLALTDERGRLIWISA
                     ARPGRTHDNTAARHDHIPAHLRATGLGALADLGFRGLDNDVRDPVIVTGFHASRTHKLT
                     AGQKNANRVLAIGRAPVEHGFAHLKNWRILAKLRTDPAHATQLLRALLVLTNLEVNR"
     gene            <800..980
                     /locus_tag="JIW86_RS39250"
                     /old_locus_tag="JIW86_39250"
                     /pseudo=""
     CDS             <800..980
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012492354.1"
                     /locus_tag="JIW86_RS39250"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="JIW86_39250"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="EHGSGLGKQRWVVERAFAHLHWFRRPADPLGDTRRHPRSLPPPGM
                     RTHLLEASELSCRSL"
     gene            complement(977..2533)
                     /locus_tag="JIW86_RS39255"
                     /old_locus_tag="JIW86_39255"
     CDS             complement(977..2533)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995212.1"
                     /locus_tag="JIW86_RS39255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39255"
                     /product="oxidoreductase"
                     /protein_id="WP_257559063.1"
                     /transl_table=11
                     /translation="MLSYDQLTSPERELWDLFPEGSRVDLRTGVPEDDRVSEGGQWGPG
                     RTVRAAVIVALLQGANTVQTGAVACLRLAGARISGHLNLAGAQIAHTLWLEDCWFEEGV
                     DLSGASTQSIAIVGSRVPGVEAGLIRIEGRLDMRRSRLGGGSASPFHRRVTALSLINAH
                     VSGAVNLSGAEISAPEEWAVSAGGLVAEGGLYCGDGFVARGEVRLMGAQLPGGLHMRGA
                     LLERPGRRGVALALDNAVASTLDFSDGFVANGTVRLRGARISDNLTFEGAVLNGPPDGH
                     GPSLVALLMQAVDFDFTLARQPSAAVDLRGAQVSYLHDSDHSWPEVVELDGFVYGSIKV
                     DEAGERREAVGRRDSVARRVAWIRRSPGYNPQPYEQLASWYRKAGHDDDARRVLLAKQR
                     HRRQTLPPAARVWGHLLEATVGYGYRPWLAGIWLLALTLLGTLSFGTRSPNPVKQGEGA
                     PFQPLVYTLDLLIPIGGLGQRTAWYWSNGSLQALAYLLIVFGWVLTTAVIAGVTRTLQK
                     S"
     gene            complement(2638..3489)
                     /locus_tag="JIW86_RS39260"
                     /old_locus_tag="JIW86_39260"
     CDS             complement(2638..3489)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139034.1"
                     /locus_tag="JIW86_RS39260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39260"
                     /product="IS5 family transposase"
                     /protein_id="WP_257559617.1"
                     /transl_table=11
                     /translation="MSARRAYRSDVSDARWALIEPVFVAWRAARSGPGTAARVHDLREI
                     VNAILYVNRTGIPWEYLPHDFPPFKTVYDYFAKWEADGTTELVHDLLRDRTRRANARSA
                     EPSAAVVDAQSVKTSSNVSEASQGIDAGKKIKGRKRHLITDTLGLVLTVLVTAASVHDS
                     VGGKQALTELAAAHPSVTKVWADGGYQTSVIQHGAGLGIDVQVVQRPRVKGFRPLPKRW
                     VIERTFGWLMQHRRLARDYEALPQRSRTMIHWAMANKMSRELTGESSPTWRIETDIPFT
                     TI"
     gene            complement(3554..3745)
                     /locus_tag="JIW86_RS39265"
                     /old_locus_tag="JIW86_39265"
     CDS             complement(3554..3745)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS39265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_39265"
                     /product="hypothetical protein"
                     /protein_id="WP_257559064.1"
                     /transl_table=11
                     /translation="MTGASKDLWDRRAGLYLALLLHLDGSMTFATDPLVPGYYGPKTPE
                     QFQLQRELAARISLLEGI"
     misc_feature    complement(3566..3568)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3753..4070
                     /locus_tag="JIW86_RS39270"
                     /old_locus_tag="JIW86_39270"
     CDS             3753..4070
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS39270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_39270"
                     /product="hypothetical protein"
                     /protein_id="WP_257559065.1"
                     /transl_table=11
                     /translation="MVRAHIATLRGAPAGQPPRPPTVRQVTGWLTRHPTALSEDDRDGL
                     KDVLARCPELDTAAGHVRGFGEILTGRLGSTLPTWIDAVEASQLPGLTASHSTCSGTLT
                     P"
     misc_feature    4117..4130
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            4117..4338
                     /locus_tag="JIW86_RS39275"
                     /old_locus_tag="JIW86_39275"
     CDS             4117..4338
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS39275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_39275"
                     /product="hypothetical protein"
                     /protein_id="WP_257559066.1"
                     /transl_table=11
                     /translation="MNRIKKIKRQLYGRAESQSRGDALVGEGSEPPGGIGVGLRFGQEG
                     AQHLDEEQARWVSGVAGRGITLRQPNLT"
     gene            complement(4498..6618)
                     /locus_tag="JIW86_RS39280"
                     /old_locus_tag="JIW86_39280"
     CDS             complement(4498..6618)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.4"
                     /locus_tag="JIW86_RS39280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39280"
                     /product="MMPL family transporter"
                     /protein_id="WP_257559067.1"
                     /transl_table=11
                     /translation="MKPSRRRAWLTVVLAMLAAVCAGVLAPAAMASLTTGGSVATGIEA
                     VHAQRRAERLGVPSPDLFLALSRAGAHPAQPPLEDGVVAVAAALAGDREVAGVWAPTAR
                     DNAWLRSRDGETMLVAARLKGVDGQPPPDVSRLIKAARTAAGGLRVEASGPAAANEEID
                     ETSARDLMRAELITAPVLFLLLIFAYGSLVAALLPVLVAVLAVGCTIPVLGLLAQVTEV
                     SWAAVNAASAIGAGLAVDYSLFLLARVREQRARGDSAQQALSTALHSTRRSIVFSAAAI
                     TACLAAALVVPVPVLRALSMAGMIVSILSAAVALLVLPALLRLLGPHTYALDPLSRWRR
                     THHENGSKFWRSTARTVTTRPLLTTALAAVLLGVITLPLGHARLGLADERTLPPSAPAA
                     AAAQHVRDTFAAPPERLLTLVVTGPDTAQGLPAYTERLARVPHIIGVRIVRPAQPANGP
                     SHTDRPSLAAVLLLASAADPGTEQAAAVVRAVRATTAPGAVLVGGRAAEVTDTITAIRN
                     TMPLCFLLLACALLTLLAAYTRTIIAPLKALLVAMASLGASLAILVVLFQDGHGRTLLG
                     NFTVTGTLDTPMLLFTLLVALALSIDYEIFLLGRIREEYDRTGSNRTAIIDGIARTGRL
                     VSSAAAALALSAAAMGTSDVSLLKFTGVGIAICALVDAVLVRGILVPAVMAALGPANWW
                     TPAPWRKPVTAS"
     misc_feature    complement(5647..5649)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6922..8265)
                     /locus_tag="JIW86_RS39285"
                     /old_locus_tag="JIW86_39285"
     CDS             complement(6922..8265)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056274.1"
                     /locus_tag="JIW86_RS39285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39285"
                     /product="FAD-binding monooxygenase"
                     /protein_id="WP_257559068.1"
                     /transl_table=11
                     /translation="MNQSVGDRAVVLGGSIAGTFSARVLSEFYREVIVVDRDRVVSVSR
                     PRRGTPHAGHAHGLHARGCLILEELFPNLLRDIRHAQLPVGDLGEQRWYFNARPFRSTR
                     TGLPSVTAQRPVLEEYFRDKVAALPNVTFLERTEVLGFLSTPDGRQVTGVRLRSTAADA
                     GSAFDLDADLLVDATGRGSRTPVWLEELGYERPVEQRMTIGLAYTTRLYRRGLDMLNGT
                     QFINCIASREFPRGAFFGQVDRETCIVSLTGILGDHPPTDPGGFLAFARSLPVADVYEQ
                     IRHAEPLSDPVCFRFPASVRRHYERLPRLPERLLVLGDAVCSLNPNYSQGMTVAAMEVM
                     ALQRHLSRGTPSTIAFMRDVGRIVNQPWFISTTSDLKYNGMAGHRGLTARMGNAYVTRL
                     HHAAAKDPAVTNALMRVAGLIDRPTALMRPRVLLGALRPQEPGTGPVE"
     gene            complement(8262..9221)
                     /locus_tag="JIW86_RS39290"
                     /old_locus_tag="JIW86_39290"
     CDS             complement(8262..9221)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="JIW86_RS39290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39290"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_257559069.1"
                     /transl_table=11
                     /translation="MTATQTPIAASIRPRPKIISYLRLAKARVYHYAYGWALGLLLLRS
                     DGFLSGGTLLAMAFMLVGTLAIQWSASAADDVSGFLNGSDARNYAGRPLVTMVRKPLLT
                     GALALPEAVRFAVAAWIGGMLAISLAAGVLDWRVPLPALVVAFGVPALAVQYSCGIKLS
                     YRPLGLESTIFFTGVCTVLVPYWFAAGTVSRETLLMSALFGLWLLLVVSYGNASDRAGD
                     AAVSRKTLAVVLPPMAFAVVLHVLVAVNAVLLVLLFTTTRLNAGFIVLSAPAVALQLAQ
                     LYYGVYRRELRKARFLVLISIDLGFLGLATALLTGRPS"
     misc_feature    complement(8802..8804)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9218..9970)
                     /locus_tag="JIW86_RS39295"
                     /old_locus_tag="JIW86_39295"
     CDS             complement(9218..9970)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962905.1"
                     /locus_tag="JIW86_RS39295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39295"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_257559070.1"
                     /sec_met_domain="PCMT (E-value: 6.1e-05, bitscore: 21.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASRYVPSLLAPAAAPGGDALFDVGLQLVERHDGGRKPQEFEMLG
                     LRWDLIPQVFAPVHTDSTQLFTQWLPFPVGGSFLEVGCGAGVTAVMAALAGCSRVTAVD
                     INPEAVHNTELNAARHGVTDRMNVLHSDLYDALAPGEQFDVVFWNSNVICAPEEFVYTS
                     PMQHAIFDRGYATHHRYLREGLARLTDSGRLFLGFNSLGDPGRLNSLAARCGVRLTEQE
                     QTTRQAGDVPVTFQLLEAAGVRDERRSA"
     gene            complement(10001..11080)
                     /locus_tag="JIW86_RS39300"
                     /old_locus_tag="JIW86_39300"
     CDS             complement(10001..11080)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058774.1"
                     /locus_tag="JIW86_RS39300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39300"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_257559071.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.9e-48, bitscore:
                     162.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLTSHGTVRADAPAPWDCSAVDGLLARFLADKEQASGGPEIAM
                     FVELLEGFLSGGKRLRPLLCYYGWQAAGGHGSTVAVTHLGAALELFHAGALIHDDVMDG
                     SDIRRGRPTVHRSLAESHGRHPSADRFGVSTAILLGNLAMCWSFDLIHVAELATPRAGM
                     LRALLDAMRMQAVTGQYLDLLAAGSSDIAVEEALAICRAKTARYTVEYPLMAGAQLAGA
                     DEGMLDACSAYGVPLGEAFQLRDDLLGVFGDPGTTGKSDLDDLRDGKHTVLLAIARQRA
                     DSVQAGALRALIGNARLDRTGAQDIRDILVATGARDAVEDMIAQRRMRALAVLDGFPFP
                     AAAAASLRHLADMATRRDR"
     misc_feature    complement(11069..11071)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11283..11296)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.35"
                     /tool="antismash"
     gene            complement(11303..11665)
                     /locus_tag="JIW86_RS39305"
                     /old_locus_tag="JIW86_39305"
     CDS             complement(11303..11665)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024673.4"
                     /locus_tag="JIW86_RS39305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39305"
                     /product="IS3 family transposase"
                     /protein_id="WP_257559072.1"
                     /transl_table=11
                     /translation="MNRCQFVEDHQRRHGVKRLCDILGLSRSSFYYWRRTAAARAARQT
                     AEAGLAARIRKAHQDSDGTYGAPRITAELRDEGGPVVNHKRVARIMRAIGLEGVRLRRR
                     HRTTVASLAPADHTPE"
     gene            complement(11662..11967)
                     /locus_tag="JIW86_RS39310"
                     /old_locus_tag="JIW86_39310"
     CDS             complement(11662..11967)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (68-83). E-value:
                     0.00054. Score: 11.5. Matches aSDomain:
                     nrpspksdomains_JIW86_RS39310_PKS_Docking_Nterm.1"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="JIW86_RS39310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39310"
                     /product="transposase"
                     /protein_id="WP_257559618.1"
                     /transl_table=11
                     /translation="MKHYPAGFKADAVALYRSRPGATVKSVAADLGVNTETLRNWIKAA
                     DGRRPGAHSAPPAAAQTGGDVVQAELTAARKRIRELEEERDILRKAARHFATETRW"
     aSDomain        complement(11719..11763)
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS39310_PKS_Docking_Nterm.
                     1"
                     /evalue="5.40E-04"
                     /label="JIW86_RS39310_PKS_Docking_Nterm.1"
                     /locus_tag="JIW86_RS39310"
                     /protein_end="83"
                     /protein_start="68"
                     /score="11.5"
                     /tool="antismash"
                     /translation="AELTAARKRIRELEE"
     gene            <12063..12515
                     /locus_tag="JIW86_RS39315"
                     /old_locus_tag="JIW86_39315"
                     /pseudo=""
     CDS             <12063..12515
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262284.1"
                     /locus_tag="JIW86_RS39315"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39315"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ALNFEPGAYKIDVPGKPLNWSAPLLANDGIRLRVSTFFSAHLDNW
                     RLCNVTENNGVLEASLWNWGNGGCATIPANIANQEQAYLTTAICGEDDLQRFCIYRDVP
                     GSSKIGVQNKCTGSMMGHDRYADGELIRQYSNGRQDGTGTYPLTGV"
     gene            complement(12838..15039)
                     /locus_tag="JIW86_RS39320"
                     /old_locus_tag="JIW86_39320"
     CDS             complement(12838..15039)
                     /GO_function="GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007261859.1"
                     /locus_tag="JIW86_RS39320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39320"
                     /product="endonuclease"
                     /protein_id="WP_257559073.1"
                     /transl_table=11
                     /translation="MTVEQLSHVDTGFLEQVEDAGRRYATRTAERDGHMEALEQHGILY
                     ADTQERVNNRLNRLGVDWAMATAIERTPETATTGTSLDLDRELVSTDLLVLERFMGRND
                     LIGIDYLEGGFLAARSVGRITVRSPGSSHHGTGFLVSPSLLMTNNHVLGSAEEAAAGVI
                     EFNFQAGVDGRPQVPVVFQLDPQSFFVTHRDLDFTVVAVSERSRDGQPLASFGRLPLKE
                     AQGKAVIGELVNIIQHPNGEPKQLALRDNQIVDVLDDFVHYSADTARGSSGAPVLNDQW
                     EVVALHHAGAPRKDRDGNVLAVDGTRWHPSMGEHRVDWKANEGVRVSRILGMIQQFPLS
                     GAAASLRTELFAAGSSLHPVEVSPPTVLTDRMNGAAPQNTTMDRSGEQPATAGSVHWSV
                     PLHISVSLDADALQPRAESPAAAPAHHATTTSYVGSLAGIGSIDGQSPAERDLAAALVN
                     LAAFRARPYYDEAADLTARDAYYAGIHAGNPTALRLALTQRLESTHERRPAYKPMRLLY
                     PWVDLQPDEKLHGIYSGKGFTPEELMEADAAVEAARIGRWQEFMLHESAPGPEAIEAEL
                     DLLEASLPFNCEHVVPQSWFAKKEPMRGDLHHLFTCEPPCNSFRGNIPYFDFPDFDEVV
                     MHGCGRREPGKFEPSKGKGPVARATLYFLLRYPGKIGDEARELQRAGLELLLNWHRDNP
                     VGIYEQHRNAAIAEMQGNRNPLIDHPEWAEQIDFAGAWP"
     misc_feature    complement(15263..15278)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            15330..15620
                     /locus_tag="JIW86_RS39325"
                     /old_locus_tag="JIW86_39325"
     CDS             15330..15620
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013252.4"
                     /locus_tag="JIW86_RS39325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39325"
                     /product="hypothetical protein"
                     /protein_id="WP_257559074.1"
                     /transl_table=11
                     /translation="MPTRIRRGAPGLAARWPAYFVAFDVLQLDGVELLARPYPERRALL
                     EELFTGHGLTAPAPWTLCPMTTDLAKAREWLESWTDVSGVEGIVRSPRRPG"
     gene            15563..16017
                     /locus_tag="JIW86_RS41860"
                     /pseudo=""
     CDS             15563..16017
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997902.1"
                     /locus_tag="JIW86_RS41860"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDGCVRSRGHRQVAEAAGVNVQTLRYYERRGLLAEPERSNGGHRL
                     YGEDAVTALRVIKAAQRLGFPWKKSPNCSRPAAIATAAPSPGSRSAPRPSSPRSTRRSP
                     TSPPSAPPWPPRSRRAATT"
     gene            15998..16312
                     /locus_tag="JIW86_RS39340"
                     /old_locus_tag="JIW86_39340"
     CDS             15998..16312
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143048.1"
                     /locus_tag="JIW86_RS39340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39340"
                     /product="hypothetical protein"
                     /protein_id="WP_257559075.1"
                     /transl_table=11
                     /translation="MPDPAADPHSHKAPKALAGLAALACVACCALPVLIAAGVLGAGAG
                     AVVGWLPALAVVLAVLAGGTWWLGQRRRSCSCGTKSTGEGGCGCQKDADPLKITSGGRR
                     "
     gene            16324..16659
                     /locus_tag="JIW86_RS39345"
                     /old_locus_tag="JIW86_39345"
     CDS             16324..16659
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128380.1"
                     /locus_tag="JIW86_RS39345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39345"
                     /product="YnfA family protein"
                     /protein_id="WP_257559076.1"
                     /transl_table=11
                     /translation="MTVARSVALFAVAALFEIGGAWLVWQGIREHKGWVWIGAGVIALG
                     LYGVVATFQSDDNFGRILAAYGGIFVAGSIAWGMVADGYRPDRYDVIGALVCLAGMAVI
                     MYAPRGN"
     gene            complement(16690..16902)
                     /locus_tag="JIW86_RS39350"
                     /old_locus_tag="JIW86_39350"
     CDS             complement(16690..16902)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268229.1"
                     /locus_tag="JIW86_RS39350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39350"
                     /product="hypothetical protein"
                     /protein_id="WP_257559077.1"
                     /transl_table=11
                     /translation="MRMRRMLGLALAAAALAGASAVGAVSAQAAASPTITGEECAAAGG
                     QVKENPYRASTCTLPDGSQQTITVG"
     misc_feature    complement(17252..17267)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.16"
                     /tool="antismash"
     gene            complement(17283..17525)
                     /locus_tag="JIW86_RS39355"
                     /old_locus_tag="JIW86_39355"
     CDS             complement(17283..17525)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS39355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_39355"
                     /product="hypothetical protein"
                     /protein_id="WP_257559078.1"
                     /transl_table=11
                     /translation="MKATASGPRAGGEAFQKGLQALQQYIAREGALPGRAVVERLPDGT
                     EHRTGIWIGNQKARRDRHDAAQLAALAELGVEWAQ"
     gene            18105..18587
                     /locus_tag="JIW86_RS39360"
                     /old_locus_tag="JIW86_39360"
     CDS             18105..18587
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010275200.1"
                     /locus_tag="JIW86_RS39360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39360"
                     /product="hypothetical protein"
                     /protein_id="WP_257559079.1"
                     /transl_table=11
                     /translation="MTVFLCSQCGTAITPELAERATVSDISDDERDRDKETRPPSTVPR
                     GHYVIVPGPWGPPYIVQDDQEDPKPAQSRGPVVCREEGFVIAAGTRHTVLVHPDDAADI
                     QPLPNWENSNGCCGPTGDEGLNRACPCGAPVATLADDCFGPYELHLDPVRTYAFSQ"
     gene            <18723..19385
                     /locus_tag="JIW86_RS39365"
                     /old_locus_tag="JIW86_39365"
                     /pseudo=""
     CDS             <18723..19385
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029007.1"
                     /locus_tag="JIW86_RS39365"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_39365"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="DCSHRLGLALNTVKRYARMPEPQALRIAPTYRPTLVGPYRDHLRA
                     RRRTDPAVPVTHLLREIRELGYTGSANLLVRYLNQGRAEGDRPVTTPRHASRLLLTDPE
                     NLCPKETTLLEKIAAACPEMTALTDLVRGFAALLKPADGNDAKLTEWIATARAIDLPYL
                     RSLTNGLEIDRAAVDAGLTLPYHNGRTEGVNTRTKRIMRQMHGRAGFDLLRHRILLP"
     gene            complement(19672..19896)
                     /locus_tag="JIW86_RS39370"
                     /old_locus_tag="JIW86_39370"
     CDS             complement(19672..19896)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS39370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_39370"
                     /product="hypothetical protein"
                     /protein_id="WP_257559080.1"
                     /transl_table=11
                     /translation="MDRAAAAESRLAPAGVWLYHDHSICDMENVGLGVIGIIVIHNPAD
                     DRNEVDVRLPGDPTSADPALLPDRVEHVT"
     misc_feature    20215..20229
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     misc_feature    20215..20230
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.21"
                     /tool="antismash"
     misc_feature    complement(20610..20625)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.62"
                     /tool="antismash"
ORIGIN
        1 acggttgtcc gtgatctctc tgaagttgtg ggcggctagg gtgacggtcg gccgacgcct
       61 ggtgtttggt gtggtgctca gcaggacgga cacggctgtt gacagcgatt tgaacgccac
      121 gtagggctgg aatccggagg accaccagtc gagcggttca ccccgctgga tggtccgccg
      181 gacggccttg agcgcttggc ggacaccgcc gagcacgtcg acctcctccc cggtcagcac
      241 gcgttcggcg gccacttggg ccaggagggc ctcgatctct ccttcggctg cggtcgcccg
      301 ctcgaggcat gctgaccttc gttcactcac cctcgccgag tgactttgca cgtcagacgg
      361 tgcggcccca ccgccgtcag cgattgactt cgaggttcgt caggacgagc agggcgcgca
      421 ggagctgggt ggcgtgagcg ggatcggtgc ggagcttggc gaggatccgc cagttcttca
      481 ggtgggcgaa gccgtgctcg actggcgcgc gtccgatggc gaggactcgg ttggcgttct
      541 tctgacctgc ggtcagcttg tgggtgcggc tggcatggaa gcccgtgacg ataacggggt
      601 cgcggacgtc gttgtccagg ccgcggaagc cgaggtcagc gagagcgccg aggccggtgg
      661 cgcgcaggtg ggccgggatg tggtcgtggc gggcggcggt gttgtcatgg gtgcggccgg
      721 gccgggcggc cgatatccag atcaggcggc ctctctcgtc ggtcagggcg aggaagtgca
      781 ggccgtgact gtggtgtttg agcacggttc gggtctgggc aagcaacgct gggtcgtgga
      841 gcgcgcgttc gcccacctgc actggttccg ccgccctgcg gatccattgg gagatacgcg
      901 acgacatcca cgaagccttc ctccccctgg gatgcgcact catctgctgg aggcgtctga
      961 actcagctgt cgctcgctag ctcttctgca gggtgcgggt gacacccgcg atgacggcgg
     1021 tcgtcagtac ccagccgaag acgatcagca ggtaggccag cgcctggagg ctgccgttcg
     1081 accagtacca ggccgtgcgc tggcccaggc caccgatggg gatcaagagg tcaagtgtgt
     1141 agacaagggg ctggaacggg gcgccctcgc cttgtttgac agggttgggg gagcgagtgc
     1201 cgaaggacag cgtgcccagc aaggtcagcg cgagcagcca gatgccggcc agccaggggc
     1261 ggtagccgta accgacggtt gcctcgagca ggtgccccca cacgcgcgcg gccgggggca
     1321 gagtctgacg ccgatggcgc tgtttggcca ggagtacgcg gcgggcgtcg tcgtcgtggc
     1381 cggccttccg gtaccagctc gccaactgct catagggctg ggggttgtag cccgggctgc
     1441 gtcgtatcca cgccacgcgg cgggccaccg agtcccgccg tcccacggcc tcccgccgct
     1501 cgcctgcctc atccaccttg atggagccgt agacgaagcc gtccagctcg accacctccg
     1561 gccagctgtg gtcgctgtcg tgcaggtagg acacctgcgc gccccgcagg tccacggcgg
     1621 cggacggttg ccgggcgagg gtgaagtcga agtcgaccgc ctgcatcagc agggcgacca
     1681 atgacgggcc gtggccgtcg ggcggcccgt tcaggacggc tccttcaaag gtcaggttgt
     1741 ccgagatccg ggcaccccgc agccgtacgg tcccgttggc gacgaacccg tcggagaagt
     1801 cgagcgtcga ggccacggcg ttgtccaggg cgagcgccac cccgcgccgg ccggggcgtt
     1861 ccagtagtgc gccccgcatg tgcagtccgc ctggcagctg tgcccccatg agacggactt
     1921 caccgcgcgc cacgaatccg tcaccgcagt agaggccgcc ctccgcgacc agtccgccgg
     1981 cggacacggc ccactcctcg ggtgcgctga tctcggcgcc gctgaggttc acggcgccgc
     2041 tcacgtgggc gttgatgagc gacaaggcgg tgaccctgcg gtggaagggc gaggcagagc
     2101 cacctcccag gcgggagcgc cgcatgtcga ggcgtccctc gatgcggatc aagccagctt
     2161 ccacgcccgg tactcggctg cccacgatcg caatcgactg ggtcgacgct ccggagaggt
     2221 ccacgccctc ctcgaaccag cagtcctcca gccagagagt gtgagcgatc tgcgcgccag
     2281 ccaggttgag gtgcccggat atccgcgctc cggcgagcct caggcaggcg acggcgcccg
     2341 tctgtacggt gttcgcgccc tgaaggagcg ccacgatcac ggcggcccga accgtccgcc
     2401 cggggcccca ctgcccaccc tcggagacac ggtcgtcctc gggcacaccc gtgcgcaggt
     2461 ccacgcggga tccctcgggg aacagatccc acagctcacg ctcgggtgaa gtcaactggt
     2521 cgtatgagag cactcgtgca gagtagtgat cttccttcgc acccgcctgc cctatggcgc
     2581 acggatcgga gggcggctca ttctgttagg agttctaaga gggcatctga tcaacgttca
     2641 tatggttgtg aatgggatgt ccgtttcgat tcgccaggtt ggtgacgatt ctccggtgag
     2701 ctcacggctc attttgttag ccatggccca gtggatcatc gtgcgggatc tctgaggtag
     2761 ggcttcgtag tcacgtgcca ggcggcggtg ctgcatcagc cagccgaagg tccgctcgat
     2821 cacccaccgc ttgggcagcg gccggaagcc cttcacgcgc ggtcgctgca ctacctgaac
     2881 atcgatcccg aggccggcgc cgtgctggat cacgctggtc tggtagccgc cgtcggccca
     2941 caccttggtc acgctcggat gggccgctgc caactcggtc agagcctgct tgccgccgac
     3001 ggagtcgtgg accgaggcgg cggtgacgag gactgtcagg accagtccga gggtgtcggt
     3061 gatcaggtga cgtttgcgtc ctttgatctt cttgccggca tcgatgccct gactggcttc
     3121 ggagacattg ctcgaggtct tcacgctctg cgcgtccacc acggctgcgg acggctcggc
     3181 gcttcgagcg ttcgcccggc gggtccggtc acgcaagagg tcatggacca gctcggttgt
     3241 tccgtccgcc tcccacttgg cgaagtagtc gtagacggtc ttgaacggcg ggaagtcgtg
     3301 gggcaggtac tcccacggaa taccggtgcg gttgacgtac aggatcgcgt tcacgatctc
     3361 tcgcaggtcg tgcacccgcg ctgcggtacc gggccctgat cttgcggccc gccaggcgac
     3421 gaacaccggc tcgatcaagg cccagcgggc atccgagacg tcactgcgat acgcacgccg
     3481 agcactcata ccccaggcaa cgaccaccgg cacgtgcagt cacaagaaca tcccaaaaca
     3541 ccaactacct agatcagatg ccctctaaga gtgagatccg ggcggcgagc tcgcgctgca
     3601 gctgaaactg ctccggagtc ttcgggccgt agtagccggg gacgagtggg tcggtcgcga
     3661 aggtcatcga gccgtcgaga tggaggagca gggcgaggta gagcccggct cgcctgtccc
     3721 acaggtcctt cgacgcgccc gtcacctacc agatggtccg cgcccacatc gccaccctcc
     3781 gcggggctcc ggccggccag ccgccccggc ctccgacggt gcgccaggtg accggctggc
     3841 tcacccgaca ccccaccgcg ctgagcgagg acgaccgcga cggcctgaag gatgtcctgg
     3901 cccgctgccc cgaactggac acggccgccg ggcatgtccg cgggttcggc gagatactca
     3961 ccggccgcct cggctccaca cttcccacct ggatcgacgc ggtcgaggcc agccagctgc
     4021 ccgggctcac cgcttcgcac tccacctgct ccgggacctt gacgccgtga cagccgggct
     4081 caccctggac tggagctcgg cagcatcgag ggcgccgtga accggatcaa gaagatcaag
     4141 cgacagctct acggtcgagc cgagtcgcag agcaggggcg acgcgctcgt cggcgagggc
     4201 tcggagccac ccggtgggat aggcgtcgga cttcgcttcg gtcaggaagg cgcgcagcac
     4261 ctagacgaag agcaggcccg ctgggtgagc ggcgtcgctg ggcggggaat cacgctgcgt
     4321 caaccaaacc tgacctgacc ggcggacggg gtcaccactc cgccgacgtt cttgagttct
     4381 tcggcggtga actcctggcc accgccgcgc gaccacccgg ccgacagcgg cgacatagga
     4441 gcgtcggatc cgatcgggac caggctctca tcgtccggtc cggctgatca gcgccgttca
     4501 ggaggcggtg acgggttttc gccatggtgc gggtgtccac cagttggcgg ggccgagtgc
     4561 tgccatgacg gcagggacga ggatgccgcg gacgagaacg gcgtcgacca gggcgcagat
     4621 ggcgatgccg acgccggtga atttgaggag gctgacgtct gaggtgccca tggctgcggc
     4681 ggacagggcg agggctgcgg cggcactgct gacgaggcgg ccggtgcggg cgatgccgtc
     4741 gatgatggcg gtgcggttgc tgccggtgcg gtcgtattcc tcgcggatgc ggccgaggag
     4801 gaagatctcg tagtcgatgg acagggcgag ggcgacgagg agagtgaaca ggagcatggg
     4861 ggtgtcgagg gttcctgtca cggtgaagtt gccgagcagg gtgcggccgt ggccgtcttg
     4921 gaagaggact accaggattg cgaggctggc tcccaggctg gccatggcga ccaggagggc
     4981 tttgagcggg gcgatgatcg tgcgggtgta ggcagcgagg agggtcagga gtgcgcaagc
     5041 caggaggagg aagcacaggg gcatggtgtt gcggatggcc gtgatggtgt cggtgacctc
     5101 tgcggcccgg ccgcccacca ggacggcccc gggtgcggtt gtggcgcgta cggcccgtac
     5161 gactgctgcc gcctgctcgg tgcctgggtc ggcggcggag gcgagcagga gcacggcggc
     5221 gagggaagga cggtcggtat ggctaggtcc gttcgcgggc tgggcggggc gcacgatgcg
     5281 gacgccgatg atgtggggga cgcgggccag tcgttccgtg taggcgggca ggccttgggc
     5341 ggtatcgggg ccagtgacga ccagggtcag cagccgttcg ggtggggcgg cgaaggtgtc
     5401 cctcacgtgc tgggcggcgg ccgccgccgg ggcggagggc ggcaaagtgc gctcgtccgc
     5461 caggccgagc cgggcgtggc caagcggcag ggtgatcact cccagcagga cggccgcgag
     5521 agcggtggtg agcaggggac gtgtggtgac cgtgcgggcg gtggaccgcc agaatttgct
     5581 gccgttctcg tggtgggtgc gtcgccaccg ggacaagggg tcgagagcgt aggtgtgcgg
     5641 accgagtaaa cgcaggagag cgggtagcac tagcagggca acggcggcgg acaggatcga
     5701 gacgatcatg cccgccatgg acagggcgcg cagtaccggt acgggcacca ccagtgcggc
     5761 cgccaggcag gcggtgatcg cggcggcgga gaagacgatg gaccgcctgg tggagtgcag
     5821 cgcggtggac agcgcctgct gtgcgctgtc gcctcgtgca cgctgctcgc ggacccgggc
     5881 caggaggaag aggctgtagt cgactgcgag tcccgcgccg atcgccgagg cggcgttgac
     5941 cgctgcccag gagacttcgg tgacctgggc aagcagtccc agcacaggga tggtgcagcc
     6001 gactgccagc acggccacca ggaccggcag gagggcggct accagggagc cgtaggcgaa
     6061 gatcagcagc agaaacagta cgggggctgt gatcagctct gcgcgcatga ggtcgcgtgc
     6121 gcttgtttcg tcgatttcct cgttggcggc agctggaccg ctggcctcca cccgcaggcc
     6181 gccggccgcc gtgcgggcgg ctttgatcag acgggagaca tcaggcgggg gctgcccgtc
     6241 cacccctttc aaacgggcgg cgaccaacat ggtctcgcca tcccgggagc gcaaccacgc
     6301 gttgtcgcgc gcggtggggg cccacacgcc ggccacttcg cggtcgccgg ccagggctgc
     6361 ggccactgcc acgacgccgt cttccaaagg cggctgcgcc gggtgcgctc cggcgcggga
     6421 cagggctagg aacaggtctg gagagggaac acccagccgt tcggcccgcc gctgggcgtg
     6481 cactgcttcg atcccggtgg ccaccgagcc gccggtggtc agcgatgcca tcgcagccgg
     6541 cgccaggaca ccggcgcaca ccgcggccag catcgccagg accacggtca gccaggctcg
     6601 tcgtctcgac ggtttcatcc gcgccctctc tggtgtgtcg cagggcctgt ccaacgatca
     6661 cgttgtcggc ccggtacgtg ccttgttctg cctcttctgc tctggctcgt ccggccgggc
     6721 cagcgcagca gaggcaggcg ggtaccgcgg agcatgagcc gtcgcgacgc cgccggtgat
     6781 ctggcggctg tgcggccaag ggggagccgg ccgaggtggc gaacgccgta aggcagcggc
     6841 cggtcattcc cggaccgtgg aggcgctcgc cgcgcgctgt gccggccagg tcggttggca
     6901 ccgcagccgt gggcggcccg gtcactcgac gggccctgtc ccaggttcct gaggtcgcag
     6961 tgccccgagg agaacgcgtg ggcgcatgag cgcggtcggc cggtcgatca gccctgcgac
     7021 tcgcatcagg gcattggtga cggcggggtc cttcgccgcc gcatgatgca accgcgtcac
     7081 gtacgcgttc cccatccgcg cggtgagccc acgatgccct gccattccgt tgtacttgag
     7141 gtcgctggtc gtcgagatga accacggctg gtttacgatc cgcccgacgt cgcgcatgaa
     7201 cgcgatggtg ctcggcgtgc cgcgtgacag gtgccgttgc agggccatca cttccatggc
     7261 cgcgacggtc atgccctggc tgtagttggg gttgaggctg cacactgcgt cgccgagcac
     7321 gagtagccgc tcgggaaggc gaggcagccg ttcgtagtgt cggcgcacgc tcgccgggaa
     7381 gcggaagcag actgggtcgc tcagcggttc ggcgtgccga atctgctcgt agacgtcagc
     7441 gacgggcagg gacctggcga atgcgagaaa tccgccggga tcggtcggtg gatggtcgcc
     7501 gaggatgccg gtcagcgaca cgatgcaggt ttcgcggtcg acctgaccga agaacgcccc
     7561 tcgcgggaac tcgcgtgatg cgatgcagtt gatgaactgc gtaccgttga gcatgtccag
     7621 gccgcggcgg tagagccgtg tggtgtaggc cagaccgatc gtcatccgct gctcgaccgg
     7681 tcgctcgtac cccagctcct cgagccatac cggcgtgcgc gatccgcggc cggtggcatc
     7741 gacgagcaga tcggcatcga gatcgaatgc gcttccggca tccgctgcag tcgaacgcag
     7801 ccggaccccg gtcacctgtc tgccgtccgg tgtggagaga aagccgagaa cctcagtccg
     7861 ctccaggaaa gtgacgttgg gcagcgcggc gactttgtcg cggaagtact cctccagcac
     7921 gggccgctgg gcagtcacgg acggcaagcc ggtccgcgtg gaccggaacg gccgggcgtt
     7981 gaagtaccag cgctgctcgc ccaaatcccc cacgggaagt tgtgcgtgcc gtatgtcccg
     8041 aagcaggttc ggaaagagtt cctccaggat taggcagccg cgggcgtgca gtccgtgggc
     8101 atgcccggca tggggagtgc cgcgccgcgg ccggctcacg ctgaccaccc ggtcgcggtc
     8161 cacgacgatg acttcacggt agaactccga gaggaccctg gccgagaacg ttccggcgat
     8221 gcttcctccg agtacgacag cccggtcgcc aacgctttgg ttcatgaggg gcgccccgtc
     8281 aggagcgcgg tggcgaggcc gaggaacccg aggtcgatgg agatcagcac gaggaaccgg
     8341 gccttgcgca actcgcggcg atacaccccg tagtacagct gggcgagttg gagtgccacc
     8401 gctggagcac tgagcacgat gaatcccgcg ttcagccgtg tcgtggtgaa aagcagaaca
     8461 agcagtacgg cattgaccgc gaccagcaca tgaagtacga cggcgaacgc catgggtggc
     8521 aggacgacgg caagggtttt ccgggagacg gcagcgtctc ctgcccggtc ggaggcgttc
     8581 ccgtacgaca ccaccaggag caaccacagt ccgaacaacg cactcatgag gagcgtctca
     8641 cggctgacgg ttccggcggc gaaccagtag ggcacgagta cggtgcagac accagtgaag
     8701 aagatcgtcg actcgagtcc cagcggccgg tagctcagct tgataccgca ggagtactgg
     8761 acagcgagag cgggcacacc gaaggcgacc accagggccg gtaagggaac ccgccagtca
     8821 agaacgccag cggcaagcga gatcgcgagc atcccaccga tccacgcggc gacggcgaac
     8881 cgaaccgcct ccggcaaggc cagcgcaccg gtgagcagtg gtttcctcac catcgtcacc
     8941 agtggccgtc ccgcgtagtt acgggcgtca ctgccgttca ggaacccgct cacgtcgtcg
     9001 gcggctgacg cgctccactg gatggccagc gtgccgacaa gcatgaatgc catggcgagc
     9061 agcgtgccgc cgctcaggaa accgtccgac cgcaggagca gcagccctag ggcccagcca
     9121 taggcatagt gatagacccg ggccttggcg agcctgaggt agctgatgat tttgggccgg
     9181 ggcctgatcg aggcggcgat cggtgtttgc gtggcggtca cgcgctcctc cgctcatcgc
     9241 ggacgccggc ggcctcaagc agttggaacg tcactggaac gtcaccagct tggcgggtcg
     9301 tctgttcctg ctccgtgagc cgcacaccgc accgggcggc cagcgagttc agccggccgg
     9361 ggtcaccgag gctgttgaac ccaaggaaca ggcgacccga atcggtcagc cgtgccaggc
     9421 cttcacgcag gtacctgtgg tgcgtggcat agccacgatc gaagatcgcg tgctgcatgg
     9481 gggatgtata gacgaactcc tcgggggcgc agatgacgtt ggagttccag aacaccacgt
     9541 cgaactgttc accgggcgcc aaggcgtcgt acagatcgct gtgcagcacg ttcatccggt
     9601 cggtcacacc gtggcgggcg gcgttgagct cggtgttgtg taccgcctcg gggttgatgt
     9661 ccaccgcggt gaccctcgag caccccgcca acgccgccat caccgcggtg acgccggctc
     9721 cgcagcccac ctccagaaag cttcccccga cggggaacgg cagccattgg gtgaacagct
     9781 gggtggagtc ggtgtggacc ggagcgaaca cctggggaat gagatcccac cgcaacccaa
     9841 gcatctcgaa ttcctgcggc ttccttcctc cgtcgtgcct ctccaccagc tgcaggccga
     9901 catcgaagag ggcgtcgcca cccggcgcag cagcaggggc gaggagtgag gggacatacc
     9961 gacttgccat gacagttcct tgttcggggt gatggcctgt tcagcggtcg cggcgggtgg
    10021 ccatgtcggc cagatgcctc agggatgcgg ccgcggcagc cgggaaagga aagccgtcga
    10081 gaacagccag ggcacgcatc cggcgttggg cgatcatgtc ttcgacggcg tcgcgtgctc
    10141 ccgtggcgac gagaatgtcg cggatgtcct gggcaccggt acggtcgaga cgggcgttcc
    10201 cgatcagggc gcgcagagcg ccggcctgga ccgagtcggc acgttgcctg gcaatggcca
    10261 gcagcacggt gtgcttgccg tcacgcagat cgtcgagatc cgatttgccg gtggttcctg
    10321 gatcgccgaa gaccccgagc aggtcatcgc ggagctggaa ggcttcaccg agcggaacac
    10381 cgtaggcgct gcacgcgtcc agcatgccct cgtcggcgcc cgccagttgc gcaccggcca
    10441 tcaagggata ctccacggtg taacgggcgg tcttggcacg gcagatggca agcgcttcct
    10501 cgacagcgat gtcggagctc cccgctgcga gaaggtcgag atactggccg gtcaccgcct
    10561 gcatgcgcat ggcgtccagc agggctctca gcattcctgc ccgaggggtg gccagctcgg
    10621 cgacatggat caggtcgaag gaccagcaca tcgcaagatt gcccaacagg atcgccgtgc
    10681 tcaccccgaa acggtcagcc gagggatgcc ggccatggct ttcggcgagc gagcggtgca
    10741 ccgtcggacg gccccgccgg atgtcgctgc cgtccatgac gtcgtcgtgg atcaaagcgc
    10801 cggcgtggaa cagttccaac gcggcaccca gatgagtcac ggcgacggta cttccgtgcc
    10861 cacccgcggc ttgccagccg tagtaacaca gcagcgggcg cagccgcttg ccaccggaca
    10921 ggaacccttc cagcagttcc acgaacatcg cgatttcggg accgcccgat gcctgctcct
    10981 tgtcggcgag gaaccgagca agcaacccat caaccgccga acagtcccac ggcgcaggtg
    11041 catccgctcg tacggtgccg tgggatgtta aaagcgacat gcaaatcctc caggtgggca
    11101 aaccgaagag acaggcaagc ggtaagacgc ccgtcatcgt gaacgccgga accactcgtc
    11161 tgccggtcac atggcgggtg agaggaccga tcaggcttcg ctgtgtcgaa atccatgacc
    11221 gcaaacgatg ccgcgaagtc gactgctgat cacgcgtaca cattcgcacc gtatcagtcc
    11281 ggacacgaag cgtgacaacc agtcattcgg gcgtatgatc tgctggagcc aatgaggcga
    11341 cggtggtccg atgccgacgg cgcagacgga ccccctcgag cccgatggcc cgcatgatcc
    11401 tcgcgacccg cttgtggttg accaccgggc cgccctcgtc acggagctcg gcagtgattc
    11461 ttggggcgcc gtaggtaccg tcggagtcct ggtgggcctt gcgtatccgg gctgcgagcc
    11521 cggcctcggc agtctgccgg gccgctcttg cggccgcggt gcggcgccag tagtagaaac
    11581 tcgagcggga caagcccagg atgtcgcaga gccgcttcac gccgtgacgg cgctggtgat
    11641 cttcaacgaa ctggcagcgg ttcaccagcg cgtctccgtc gcgaaatgcc gggccgcctt
    11701 gcggagaatg tcgcgctctt cctcgagctc acggatcctc ttgcgtgccg cggtcagctc
    11761 cgcctgaacg acgtcacctc cggtctgggc agcggccggc ggcgcggaat gagcgccggg
    11821 gcggcgtccg tcggcggcct tgatccagtt ccgcagcgtc tcggtgttca ccccgagatc
    11881 agccgcgacc gacttgaccg tcgctcccgg cctcgaccgg tacaacgcga ccgcgtccgc
    11941 cttgaacccg gcgggatagt gcttcatccc cacggggact ccgttctcct ggaccatcaa
    12001 gatccaagtc tctccggtgt ccaaaatccg gggtcagggc cccaaagggt ggtccccctc
    12061 ccgcgctcaa cttcgagccc ggcgcctaca agatcgacgt ccccggcaag cccttgaact
    12121 ggagcgcacc gctcctggcc aacgacggca tccgcctgcg cgtatctaca ttcttcagcg
    12181 cccacctgga caactggcgc ctgtgcaacg tgacggagaa caacggagtc ctcgaggcgt
    12241 ccctgtggaa ctggggcaac ggcggatgcg cgaccatccc ggcgaacatc gccaaccagg
    12301 agcaggccta cctgacgacg gccatctgcg gggaggacga cctccagcgg ttctgcatct
    12361 accgcgacgt acccggcagc tcgaagatcg gtgtgcagaa caagtgcacc ggctccatga
    12421 tgggccacga ccggtacgcg gacggggagt tgatccgcca gtactccaac ggcaggcagg
    12481 acggtacggg tacgtacccc ctgaccggag tctgacggcc cacaccccgt gatcggcccc
    12541 gcacgtgaac ccccgacctc ccggttccgt gcggggccct ccgcgtccct actccggttc
    12601 tgccgggtca ggcggctgtg ccgaaaccgg agcggtcggc tccatgggtc ctttgcatga
    12661 ttcgccatgg gtttcgacgc cgtcagcacc aacgcttcct acgacggctg ccggggcggc
    12721 gtacacacgc ccggatccca ggattagcaa cggtccagtt aatcctcgcg ccgtccaccc
    12781 ctcgcgccgg ctcctcctgg agtcggcgcg agggatggac gggacgggat cgtcaggtca
    12841 gggccaggca cccgcgaagt cgatctgctc ggcccactcc gggtggtcta tcagcggatt
    12901 gcggttgcct tgcatttcgg ctatcgccgc gttgcggtgc tgctcgtaga tgcccaccgg
    12961 attgtccctg tgccagttca gcagcagctc aaggccggcc cgctggagtt cacgcgcctc
    13021 gtcgccgatc ttgccggggt agcggagcaa gaagtagagc gtcgccctgg cgaccggccc
    13081 cttgcccttc gagggctcga acttacccgg ctcccggcgc ccgcagccgt gcataacgac
    13141 ctcgtcgaag tccgggaagt cgaagtaggg gatgtttccg cggaagctgt tgcacggggg
    13201 ctcgcaggtg aagagatggt gcaggtctcc gcgcatcggc tccttcttgg cgaaccagga
    13261 ctggggtacg acgtgttcgc agttgaaggg cagcgacgcc tccaggaggt cgagctcggc
    13321 ttcgatggcc tccgggccgg gcgcactctc gtggagcatg aactcctgcc agcgtccgat
    13381 ccgcgcggcc tccaccgccg cgtcggcctc catgagctcc tccggggtga agcccttgcc
    13441 cgagtagatg ccgtggagct tctcgtcagg ctgcaggtcc acccacgggt agagcagacg
    13501 catcggcttg tacgctggcc ggcgctcgtg cgtggactcc aggcgctggg tgagcgccag
    13561 gcgcagggct gtggggttgc cggcgtgaat gcccgcgtag taggcgtcgc gtgccgtcag
    13621 gtccgcggcc tcgtcgtagt aggggcgggc cctgaaggcc gcgaggttga ccagggcggc
    13681 tgccaggtcc cgctcggcgg gcgactgacc gtcgatactt ccgatcccgg ccagcgaccc
    13741 gacgtacgag gtggtggtcg catggtgcgc cggtgccgca gcaggtgatt cggcccgggg
    13801 ctgcagggcg tcggcgtcga ggctgacgct gatgtgcagg gggacgctcc agtggacgga
    13861 tcctgccgtg gcgggctgct caccgctccg gtccatcgtg gtgttctggg gcgcggcgcc
    13921 attcattcgg tccgtcagga ccgtcggcgg cgagacttcc acggggtgca gggacgagcc
    13981 ggccgcgaac agctccgtcc ggagcgacgc ggcagcgccg gacagtggga actgctggat
    14041 catgccgagg atgcggctga cccgcacgcc ctcattggcc ttccagtcca cccggtgctc
    14101 tcccatgctc ggatgccagc gggttccgtc gacggccagc acgttgccgt cgcggtcctt
    14161 gcggggagca cctgcgtggt gcagtgccac gacctcccac tggtcgttga gcaccggagc
    14221 gcccgaggag ccacgcgccg tgtcggccga gtagtgcacg aagtcgtcca gcacgtccac
    14281 gatctggttg tcccggagag ccagctgctt gggctcgccg ttggggtgct ggatgatgtt
    14341 gacgagttct ccgatgacgg ccttgccctg agcttccttg agcggcagtc tcccgaagga
    14401 cgccagcggc tgaccgtccc gggagcgttc ggagaccgcg accacggtga aatcgaggtc
    14461 acggtgggtg acgaagaagc tctgtggatc gagctggaac acgaccggga cctgcggccg
    14521 cccgtccacg cctgcctgga agttgaattc gatgactccg gcggccgcct cctcggcgga
    14581 gcccagcacg tggttgttcg tcatcagcag tgagggggac accaggaaac cggtgccgtg
    14641 gtgggacgac ccgggactcc ggacggttat tcggccgacc gagcgggcgg cgaggaaacc
    14701 gccttcgagg tagtcgattc cgatgagatc gttgcggccc atgaaccgtt cgagcaccag
    14761 taggtcggtg ctgaccagct cgcggtccag atccaggctc gtaccggtcg tggcggtctc
    14821 cggtgtccgc tcgatcgctg tggccatggc ccagtcgacg cccagacggt tcagcctgtt
    14881 gttgacccgt tcctgggtgt cggcatagag gatgccgtgc tgctcgagcg cttccatgtg
    14941 gccgtcacgc tccgcggtac gggttgcgta gcgccgaccg gcatcctcca cctgctccag
    15001 gaaacccgtg tcgacgtgtg acaactgctc cactgtcatc tcggctcgcc tcctcggcgg
    15061 cactcttccg cgctcagatg tcggatttcc tcccccattt cagtatgggc acagggcctg
    15121 gggtgccgct cagccgaaca gcgggacgct ccggagtggt tgttgcgtca atctttgaac
    15181 tgtctccgat ttcgggatga cggcgatttc gctgctgccc cggcacccga gccgttgcgc
    15241 gggatgcttc gtctggtcac agagtggttg agaccacttg ccccgtgtat aagtcattct
    15301 ggcctccgcc cagttgtgtg ctcgacgtga tgccgacccg catccgccgc ggcgctcccg
    15361 gtctggccgc caggtggccg gcctacttcg tggctttcga cgtgttgcag ctggacgggg
    15421 tggagctcct ggcgcgcccg tacccggagc gccgcgcact cctcgaggag ttgttcaccg
    15481 ggcacggcct gacggcccca gccccgtgga ccctgtgccc gatgaccacg gacctggcca
    15541 aggcacgcga gtggctggag tcctggacgg atgtgtccgg agtcgagggc atcgtcaggt
    15601 cgccgaggcg gccggggtga acgtgcagac gctgcgctac tacgagcggc ggggcctgct
    15661 ggccgagccg gaacgcagca acggcggaca ccgcctgtac ggcgaggacg cggtgaccgc
    15721 gctgcgggtg atcaaggccg cgcagcggct cggcttcccc tggaagaagt cgccgaactg
    15781 ctcgaggccg gccgccatcg ccacggccgc cccgtcgccg ggctccagga gcgcgcctcg
    15841 gccaagctcg ccgaggtcga cgcgaagatc gccgacctca ccaccatccg caccgccctg
    15901 gccaccgcgg tcgaggcggg ctgcgacgac ctgaccgtgt gcgcgtccag cgcctgctgt
    15961 cccattccct tcaccgacct tgccgaggag aaccgccatg ccggaccctg ctgctgaccc
    16021 ccactcccac aaggccccca aggcgcttgc gggtctggcc gctctggcct gcgtggcgtg
    16081 ctgcgcgctg cccgtcctga tcgccgcggg cgtcctgggg gccggcgcgg gtgcggtggt
    16141 gggctggctg cccgccctcg ccgtggtcct ggccgtgctc gccggcggga catggtggct
    16201 cggacagcgc cgccgctcct gctcttgcgg cacgaagagc acaggtgagg gcgggtgcgg
    16261 ctgccagaag gatgccgacc cgctgaagat cacgagcggg ggccgtcgat agggttcgcc
    16321 ggtatgactg tcgctcgttc cgttgccctg ttcgccgttg ccgccctctt tgagatcggc
    16381 ggggcctggc tggtgtggca gggcatccgc gagcacaagg gctgggtgtg gatcggcgcc
    16441 ggcgtcatcg cgctgggcct gtacggggtg gtggccacct tccagtccga cgacaacttc
    16501 ggccgcattc ttgccgcgta cggcgggatc ttcgtcgccg gatccatcgc ctggggcatg
    16561 gtcgccgacg gctaccgccc tgaccgctac gacgtcatcg gcgccctggt ctgcctcgcg
    16621 ggcatggccg tgatcatgta cgcgccccgc gggaactgac cccgcccggc cgtcccggac
    16681 cgcttgacgt cagcccaccg tgatcgtctg ctgactcccg tcaggcaacg tgcaggtgga
    16741 ggccctgtac gggttctcct tgacctgtcc accagcggcc gcgcactctt ccccggtgat
    16801 ggtcggagac gcggcggcct gagcgctgac agcaccgacc gcgctcgcgc cggccagggc
    16861 ggctgcagcc aaggcgaggc ccagcattct tctcatacgc atgacttcct cctctcaggc
    16921 gcccccgttc ggccctttca aggacaagtc tcgggccgac aacgccctcc tcctcagcat
    16981 gggcgatgca caggaggccc gcgaggcgag tcgcgcgccg caacagggat ccggtcgagg
    17041 gccagtgcgg gagtcacccg gagcgcaagg ctggcaggcg ctccgcctga tgggcgtcgc
    17101 ggattcttca ctggttcggc ggcgggtgtt tcaccagcgt gcgggggcgt tgagttgggg
    17161 cgtgtcgttt gtgtagtgca ggcgtgtgcc gtttcgcgga tggacggcat ggcgcgcctg
    17221 tagggccctt gacctacggt cgcccggggg ctgaccgcca ccagcgtgca gcgctcgcgc
    17281 gcctactgcg cccattccac gcccagctcg gcgagcgcgg caagctgcgc cgcgtcgtgc
    17341 cggtcgcggc gcgccttctg gttgccgatc cagattccgg tgcggtgttc ggtgccgtcg
    17401 gggagccgtt cgacgacggc gcgccccggc agggcgcctt cccgtgcgat gtactgctgg
    17461 agggcctgga ggcctttctg gaaggcttcg ccgcccgcgc gcggcccgga cgccgtagcc
    17521 ttcatcgccg ccgccctgcg ggcccgcccg accgcctgcg gcttgacgcc gtgtgcggcg
    17581 agtcggtgtt gctgttcgtc gttgagccgg ttccagttgc gtcgttgggt ggcgagccat
    17641 cgtccgacgt cctcgccgtg ccgggtgaca ccggggacga cagcggtcag acgcgccccg
    17701 tcgtcgagga gctgggtgag gtaggcgtag tggcgttgcc agtcgacggt ccacccgagc
    17761 gtccgcgggt tccagtcggg gtcgatggcg gcgagcgcgg cggcccgctg ctgcgcccgg
    17821 tcggggttct tgccgagtcc gccgggccgg cggatgttgg tcagccactg cccgacggcg
    17881 atgccgaggc tggtggcatg ccggggggcg gctcggcgag gtcgccgcga tcgaagccag
    17941 cctcgccgcc gccgagcaga agctcgccgc catgcgcgac ctcgccaccc ggcacaccac
    18001 cgtccacctg ggcatgcccg atttccgcag cgtcgtcgcg cgcatcgacc ccgagcagcg
    18061 aaacgagggt gcgaagcagc agtcctgagc actacaacga ggggatgacc gtcttcctct
    18121 gttcccagtg cggcaccgcg atcacgccgg agctggccga gcgtgccacc gtctctgaca
    18181 tctccgacga cgagcgcgac cgggacaagg agacacgccc accttccacc gtcccacggg
    18241 gccactacgt gatcgttccc gggccctggg gacctcccta catcgtgcag gacgatcagg
    18301 aggaccccaa gcccgctcag tcgcgcggac ctgtggtctg ccgtgaagaa ggcttcgtca
    18361 tcgcggccgg cacgcgacac acagtgctgg tgcatcccga cgacgctgcc gatatccagc
    18421 ccctgcccaa ctgggagaac agcaacgggt gctgcggacc gacaggcgac gaggggctca
    18481 accgcgcctg cccctgcggc gctcccgtcg ctaccctcgc ggacgactgc ttcgggccct
    18541 acgaactgca cctcgacccc gtccggacct acgcgttctc ccagtgagac cgcgaagcgc
    18601 gcgtggacga tgcactcgac acgcccggcg gagcgagtcc acccaacttc ttcacgacta
    18661 ctttccgtcg tgaaatccag ctcgcagacg ggcctgtcac tgagctgggc tagttcggat
    18721 aagactgctc ccaccgcctg ggcctggccc tgaacaccgt caaacgctac gcccggatgc
    18781 ccgaacccca ggccctgcgt atcgccccca cctaccggcc caccctcgtc ggcccctacc
    18841 gcgaccacct ccgcgcacgg cgccggaccg accccgccgt gcccgtcacc cacctgctgc
    18901 gggagatccg agagctgggc tacaccggca gcgccaacct gctggtccgc tacctcaacc
    18961 agggccgcgc cgaaggcgac cgccccgtca ccaccccgcg ccacgccagc cgcctcctgc
    19021 tcaccgaccc cgagaatctg tgcccgaagg aaacgaccct gctggagaag atcgccgcgg
    19081 cctgcccgga gatgaccgcg ctcaccgatc tcgtacgcgg cttcgccgcc ctgctgaagc
    19141 cggccgacgg caacgacgcc aaactcaccg agtggatcgc caccgcccgc gccatcgacc
    19201 tgccctacct gcgcagtctc accaacggcc tcgaaatcga ccgggccgct gtcgacgccg
    19261 gcctcacctt gccctaccac aacggccgca ccgaaggcgt caacacccgc accaagagga
    19321 tcatgagaca gatgcacgga cgcgccggat tcgacctcct ccgtcaccgc atcctcctac
    19381 cgtgacggct acctggcgtc accaccgact acgggacaga gccactgtgc gaggtgaaca
    19441 ggtcacagag gcctcgccct cgacctgccc ggcgactctg cccccgattc cgcggtagac
    19501 gagtaattcc gaagtgctgg tcagtggtcg taggcgatga gtgatcgggt gatgggtgtt
    19561 ccgttggccc ggttgtgcca ggtggctgcg gtcagggcga ggatgtgttg gggtcaaggc
    19621 cccaacgccc gactcgaatg tcggcccacc ggccagccgg ccgtggtcga cttacgtgac
    19681 gtgttcaacg cgatccggca gcagggcggg atcggctgac gtcgggtcgc cggggagccg
    19741 gacgtccacc tcgttccggt catccgcagg gttgtggatc acgatgatcc cgatcactcc
    19801 gagcccgacg ttctccatgt cgcagatgga gtggtcgtgg tagagccaga cacccgccgg
    19861 cgccagcctt gactcggcgg ccgccgcgcg atccatacgg gccaggcggt tccacgagcg
    19921 tttctggcgc cttgccagcc gttccccggg atgtcgggga attccacgaa agcctcaccc
    19981 gttcggcttg attccttgac cgccgggcga ggcatgaacg gggcgcctgc caccgccgag
    20041 tctccgcacc gcccatcctg gccaacaccg gatacgtgtc cggtaagcct cccgcgtccg
    20101 aacggagttt ccgttgagtt atcttcagtt cccgcgcctg cacttctcag gaaggttcgt
    20161 tttcgaccct tccaccgtca acaacgaccc aaggcacttc aacaacgaca cgttccaacc
    20221 tcgttttcac agacgcagtc ggtccgcgaa ggacggctgg tggaatccac ggggaagcgc
    20281 ctcgttccgc ctgcgcggct gcagggtgac cagcgtcgtg ggggcggatg gccgcctggt
    20341 gacgtccggt gcgatcgagc ccgtcgtcgg cggctccctg atggacgacg gcgatcgcgt
    20401 cagcgcaaag atccaggatc tggacccagt gcagcagggc gtctcccaga tctggggcct
    20461 ggggcttcgg ctgttcgaca gcgggcagcg gccagtgctg tacggggact tccgccacgc
    20521 ctcgttcgtc gacctgtggg cgcgctgccc ccaagccaca ggtctggacg ggtactccgc
    20581 cgcctaccag tccgtcatca ggctcagccc tgaccagacg gacacggggt cgtcgacgtt
    20641 cctgaaggaa ctggtggaga gcacggccga tgacgagttg tccatcaagt tcatgctcga
    20701 cggctacgaa gccgactggg actcgccgcg gttcggcacg ggccgtatcg tgggctccat
    20761 cgggccgacc gcgtccggag agccccggca cttcaccgcg gcgcgccgac tgcgcagccc
    20821 agccgagggc ggacctctca tggacgcgcc gtgccgcatc gacgggcagg accggctgca
    20881 catcgatctg ggcaacagcg tccccaccag tacccccggc ggccctcccc tcgacagcat
    20941 cggcctcctt caggtggtgg ccctgccgaa gggcggcggc gagccggatg tgctggctca
    21001 gctcggcccc ctcgacgaca ggttcctcac cgagcgcgcg ggcatcgcca ccatccaact
    21061 cgggcagggc aaggcgacgt
//
