LOCUS       NZ_CP102509            22643 bp    DNA     linear   CON 06-JAN-2024
DEFINITION  Streptomyces sp. NBC_00162 chromosome, complete genome.
ACCESSION   NZ_CP102509
VERSION     NZ_CP102509.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NBC_00162
  ORGANISM  Streptomyces sp. NBC_00162
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8635149)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Joergensen,T.S., Klitgaard,A.,
            Mourched,A.-S., Blin,K., Larsen,T.O., Weber,T., Gotfredsen,C.H. and
            Charusanti,P.
  TITLE     Identification of the biosynthetic gene cluster for pyracrimycin A
            and elucidation of a key reaction during its biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8635149)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/05/2024 18:03:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,275
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,805
            CDSs (with protein)               :: 7,805
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 371
            CDSs (without protein)            :: 370
            Pseudo Genes (ambiguous residues) :: 0 of 371
            Pseudo Genes (frameshifted)       :: 186 of 371
            Pseudo Genes (incomplete)         :: 231 of 371
            Pseudo Genes (internal stop)      :: 27 of 371
            Pseudo Genes (multiple problems)  :: 68 of 371
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:41:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8027348
            Orig. end                         :: 8049991
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22643
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="33"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22643
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22643
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12643](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12643
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(308..754)
                     /locus_tag="JIW86_RS36970"
                     /old_locus_tag="JIW86_36970"
     CDS             complement(308..754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005313821.1"
                     /locus_tag="JIW86_RS36970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_36970"
                     /product="hypothetical protein"
                     /protein_id="WP_257558694.1"
                     /transl_table=11
                     /translation="MRRTGTILGAAALTMLTIPANAHAAAIACGGGTSTGRVAINGCIS
                     AQRGSVGEFPSREITAHIKARNTGTKGLNVSYEAFFRVVDGGHWEKVGSGRSYVRAGEA
                     IGPVEVGSTTRVCGPVKVEIRVHARADGAAWSGWSPASTKQCQT"
     misc_feature    896..909
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     gene            1131..1742
                     /locus_tag="JIW86_RS36975"
                     /old_locus_tag="JIW86_36975"
     CDS             1131..1742
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072840.1"
                     /locus_tag="JIW86_RS36975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_36975"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_215140456.1"
                     /transl_table=11
                     /translation="MNQRFTWPDERLIRAAQDGDVTSLTTVVMESQPHVRRFAISLCAS
                     PQDAEDAAQEALIILYRKIGTLRATGALASWMFRIVRNECLRQVRLLVSRSDEASAGPD
                     GSAEQSAEPSAEDAVLHRLEAERIAAAVSSLPSDQRQVLILRDVQGLPGRTVAHSLGLS
                     NAAMKSRLHRARAALRHSLAVTDQAPDQAIAQPVGGDSRP"
     gene            1739..>2071
                     /locus_tag="JIW86_RS36980"
                     /old_locus_tag="JIW86_36980"
                     /pseudo=""
     CDS             1739..>2071
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037681.1"
                     /locus_tag="JIW86_RS36980"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_36980"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNTLNTLNTVKPAQAAKARAITQSAGPEMNFASKSVPRHLGRGAI
                     GFGLIIGSIALVPVVGPVTLLAAPLALIAFRGCPTCWMVGLAQTISRGRLERQCVDGVC
                     TLTKAHP"
     gene            complement(2072..2512)
                     /locus_tag="JIW86_RS36985"
                     /old_locus_tag="JIW86_36985"
     CDS             complement(2072..2512)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047669.1"
                     /locus_tag="JIW86_RS36985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_36985"
                     /product="DUF2809 domain-containing protein"
                     /protein_id="WP_257559586.1"
                     /transl_table=11
                     /translation="MIPGTRDRSAADPVRTRLAAAGAAVVIVGVGLGLRAVAAGSVAKY
                     GGDALYTVLLLALVVLAAPRVTPLKAAGCALAVSWLVEFLQLSGVPAELSERSTVARFA
                     LGSTFNPPDLLWYAVGAAAGWLIHTVVTTRHSVGSRLVRGHR"
     gene            complement(2655..3095)
                     /locus_tag="JIW86_RS36990"
                     /old_locus_tag="JIW86_36990"
     CDS             complement(2655..3095)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.4"
                     /locus_tag="JIW86_RS36990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_36990"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_257558695.1"
                     /sec_met_domain="PF07366 (E-value: 1.7e-07, bitscore: 29.9,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPETLSPREVFQKLIEGIGAGRFTELAELYAEDAVVETVFEPVGP
                     RRVEGRAALRERFAQVSASSPVELTPVNVVVRETDDAEVVVAEFDYQVHHRVTGRTFEA
                     ANIQVLRVRDGLIVSSRDYHDHLALVVAGGNLPQLVEALDGK"
     gene            3217..3789
                     /locus_tag="JIW86_RS36995"
                     /old_locus_tag="JIW86_36995"
     CDS             3217..3789
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF044515.1"
                     /locus_tag="JIW86_RS36995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_36995"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_257558697.1"
                     /transl_table=11
                     /translation="MGGAQERPLRADAARNRARLLDVATEVFTTRGVGVPTEEIARIAG
                     VGVGTLFRHFPTKEALLEAVMVRRLEEMAARTAQLAAESGPAEAFFACFRLVVEQSEGK
                     NEFAQALAVAGVDVHASLQEPTMEIQARLADLLAGAQRAGAVRPELGLPEFIALLAGTG
                     RAMEQLGVDPAPRERIFEVVFDGLRPR"
     gene            4009..4689
                     /locus_tag="JIW86_RS37000"
                     /old_locus_tag="JIW86_37000"
     CDS             4009..4689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077676.1"
                     /locus_tag="JIW86_RS37000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37000"
                     /product="transcriptional regulator"
                     /protein_id="WP_257558699.1"
                     /transl_table=11
                     /translation="MEDIDAIAVLQDRVRRRLYEYVAAQGREVGRNEAAEAVGVARTLA
                     AHHLDRLTEAGLLESGSRRLTGRSGPGAGRPAKVYTRARAEWSVSLPARDYRTAAELLA
                     EAAEQAGLDAGLCAAARRRGEALRGSAEPCGGLEEAMEMLAARGYEPHLEGIEGAEGAA
                     GPVVRMRNCPFHAVAERFPPLVCGMNLALLEGLLGADGPVRARMDARPGECCVVVETSK
                     NNDD"
     gene            4722..5246
                     /locus_tag="JIW86_RS37005"
                     /old_locus_tag="JIW86_37005"
     CDS             4722..5246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670410.1"
                     /locus_tag="JIW86_RS37005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37005"
                     /product="DUF3291 domain-containing protein"
                     /protein_id="WP_257558700.1"
                     /transl_table=11
                     /translation="MTASTHAAHLAQLNVATLLYPFDDPRVAPFVEMLDPVNSAADGAP
                     GFVWRLAEEGEADATGLRPAGEDVIVNLSVWETQEALWDFAYRSGHLEVMRRRREWFER
                     HVEAHLVLWWVPAGHLPTADEALERLADLQAHGPSPRAFTFASSYTAAEAAQHLQTVPP
                     AQPEQAAGARG"
     gene            5416..6174
                     /locus_tag="JIW86_RS37010"
                     /old_locus_tag="JIW86_37010"
     CDS             5416..6174
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005322092.1"
                     /locus_tag="JIW86_RS37010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37010"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_257558701.1"
                     /transl_table=11
                     /translation="MDWSIAEVARISGVTARTLRHYDEIGLLPPARIGANGHRYYEDRQ
                     LLLLQQILVLRALGVGLPEIGRILSEQVAEVDALRGHHRRLLAERDRLDALAGTVFRTI
                     VELEQSGKDGRPMTINRPENLFEGVQPSQYEENMRDFPELAEEVGRRAATMSQADAEAG
                     HRERTAQMIRLAELMAAGHRADAEPVQAEIGAQYGALTELRAVSAEEYRAIGRSCVDNE
                     AWRAAYEAITPGLAAYQRDAIDAYATSRLS"
     gene            complement(6193..6972)
                     /locus_tag="JIW86_RS37015"
                     /old_locus_tag="JIW86_37015"
     CDS             complement(6193..6972)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (19-126). E-value: 2e-11.
                     Score: 35.9. Matches aSDomain:
                     nrpspksdomains_JIW86_RS37015_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383727.1"
                     /locus_tag="JIW86_RS37015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37015"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_257558702.1"
                     /sec_met_domain="PF00561 (E-value: 7.8e-07, bitscore: 27.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.3e-15, bitscore:
                     56.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIRVGQVVVHYVEYGTGRPVLVLHGAGVDHREAEACFELAFDGV
                     AGLRRIYPDLPGMGRTVAPGTLRSADDVLDTLLDFADEVTGGSAHLLVGHSAGAYYAQA
                     MAARRPAQVAGLALVCPLLSELRDVPEHRVVAGSGEIGDDVFRSYFVIQTPEMLERYER
                     YVAPAAALVDHAALERIGERWTLTPDHAPAYAGPTVVVAGRLDSTVGYAAATDLVDHYP
                     HASLAVADDAGHALPHEQPELLRALLTDWLARVERSS"
     aSDomain        complement(6595..6915)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS37015_Abhydrolase_1.1"
                     /evalue="2.00E-11"
                     /label="JIW86_RS37015_Abhydrolase_1.1"
                     /locus_tag="JIW86_RS37015"
                     /protein_end="126"
                     /protein_start="19"
                     /score="35.9"
                     /tool="antismash"
                     /translation="PVLVLHGAGVDHREAEACFELAFDGVAGLRRIYPDLPGMGRTVAP
                     GTLRSADDVLDTLLDFADEVTGGSAHLLVGHSAGAYYAQAMAARRPAQVAGLALVCPLL
                     SEL"
     CDS_motif       complement(6649..6699)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIW86_RS37015_0001"
                     /evalue="6.70E-05"
                     /label="NRPS-te1"
                     /locus_tag="JIW86_RS37015"
                     /protein_end="108"
                     /protein_start="91"
                     /score="15.5"
                     /tool="antismash"
                     /translation="LVGHSAGAYYAQAMAAR"
     misc_feature    complement(7042..7055)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.28"
                     /tool="antismash"
     gene            7415..8656
                     /locus_tag="JIW86_RS37020"
                     /old_locus_tag="JIW86_37020"
     CDS             7415..8656
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572754.1"
                     /locus_tag="JIW86_RS37020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37020"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_257559587.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 5.4e-43, bitscore:
                     146.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRALGEGPLGAVEQADVLMRDGLISAVGKRLPAPPGTQVIDAAG
                     KLVMPGFVDVHTHLWQSSMRGGCADRDLFGWLADCNWRTFSRIAPADMYRFVRLGALDS
                     LQSGVTTLVDWVDAIPYDTTVQYVRALADTGVRFAYAMFQAERDATLITRAKRELIDPV
                     PLASAQVATHAARAIQGLNRVHWEIAQDLGVMLNSHVLERSEQRADDPIGTLTDIGALG
                     PRLLMNHAIHLTDDELAAVASHDVRVSHCPLSNMRLASGIMRLPDFGRRGVKVGLGQDG
                     GTNDTSDFFALMKTAVGLQRVRAQETSVFPQIHDVLRIATLGGAEAIGMADTVGSLTPG
                     KSADVIVIDPAALNFAPRFDWINQIVLNGRPENVHAVFVNGRPLKLNGRLVDVDPGRVV
                     HEAEAAAARLRAVS"
     gene            8803..9846
                     /locus_tag="JIW86_RS37025"
                     /old_locus_tag="JIW86_37025"
     CDS             8803..9846
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS37025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_37025"
                     /product="hypothetical protein"
                     /protein_id="WP_257558703.1"
                     /transl_table=11
                     /translation="MVEQVLAIFTQMAGGTAAVVGAEVGHAVSTIVRDRLGTTEQGRAA
                     ISTVETSPTDPAAVEQLRDIVESEMAADPRFAERIALALAGPPPASAPRINTGISFDNS
                     PVRGRPIISMAGVTVSNTRNVRFSLLAAALVLVALLALGLYGGTQLFNGDDSPAQGGAG
                     SPKSATAIKDAALAKTIPPGMDSLPTGWSVGSGYPKEFRCGGMPAKCRDALLDIQTSYT
                     PGFYFDQAQIEVVTYPSVEAATAGYAEIKRENADFGSTPTPVAMSNAGGDESAAVEWAN
                     SPTPGITEATGAFAVVRVGTVVINVVMMDEGAGGTDLGILQSFAATATARAQQTQNGQA
                     PSAVMTR"
     misc_feature    8818..8820
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..12643
                     /gene="lanKC"
                     /locus_tag="JIW86_RS37030"
                     /old_locus_tag="JIW86_37030"
     CDS             10001..12643
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992235.1"
                     /locus_tag="JIW86_RS37030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37030"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_257558704.1"
                     /sec_met_domain="micKC (E-value: 7e-239, bitscore: 794.0,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.6e-10, bitscore: 38.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.1e-08, bitscore:
                     31.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAAFCDSDRWFYDAPYRRVGESYAAALAPVPPGWRSHRSGD
                     WLALRPVGAELPAQGWKIHVSATLDNAESVLTTVYEYCTSRGIAFKFIPSRYLLHLRNA
                     KYADRAASGKFITVYPADEQQCGRIAEDLDASLAGAAGPYILSDLRWAAGPVHLRYGSF
                     TLRHCYDEHGALVPAIEAPDGRLVPDRRGPAFQPPEWLELPDFLKPHLAARSAVTLTGV
                     PFTVERALHFSNGGGVYLGKDSRTGEAVVLKEARPYAGLAADGADAVTRLHREQAALER
                     LTGLGCVPEVRGTFTVGDHHFLVLEHLAGKPLNTYFARRHPLIEADPDPAELASYTEWA
                     LTIHRRVTEAVDAVHARGVVFNDLHLFNIMVAEDETGEPSVALLDFEAAAHVDEGLRQT
                     VANPAFVAPAERRGFSVDRYALACLRLALFLPLTSLLVLDRAKAAHLAAVAAEQFPVPR
                     RFLDEAVEEILSGVPQGAPGDRVPAPAGPYLPVEPREWPAARTSMTAALRASATPDRED
                     RLVPGDIAQFATAGGGIGFGYGVAGVLHALAETGAEPWPEAEEWLLDRTAEPASGTPLG
                     FYDGLAGTAWTLHRLGHHDRALALADLLLHQPWESAGPDLHSGLAGIGLALDALGTASG
                     ESELHAAALRCAELIARPEHRPTRAGLLYGNSGPALLLVRLYERTGDKELLIQAAHALH
                     RDLDRCVTSAYGTLQVNEGWRTMPYLGEGSVGIGMVLDDWLEHGPDERFEQARREIVRA
                     AQATFYAQPGLLRGAAGMILHLARTTTPGPGTGPQAIARQIDALARHAVPYQGHLAFPG
                     EQMMRLSMDLATGTAGALLALGSAAPGGRAHLPFLPPLRERGAPKPVPPGAVTHRTTRE
                     KKRNRHDAS"
     misc_feature    10295..10297
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12630..12764
                     /locus_tag="JIW86_RS37035"
                     /old_locus_tag="JIW86_37035"
     CDS             12630..12764
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="JIW86_RS37035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37035"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_257558705.1"
                     /transl_table=11
                     /translation="MTLLDLQSMETPKEESTEAAMTGGGSRASLLLCGDSSLSLTTCH"
     CDS_motif       12630..12692
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTLLDLQSMETPKEESTEAAM"
                     /locus_tag="JIW86_RS37035_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12693..12764
                     /prepeptide="core"
                     /locus_tag="JIW86_RS37035_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="19.10"
                     /molecular_weight="2092.3"
                     /monoisotopic_mass="2091.1"
                     /core_sequence="TGGGSRASLLLCGDSSLSLTTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTLLDLQSMETPKEESTEAAM"
                     /leader_location="[12629:12692](+)"
                     /alternative_weights="2110.3"
                     /alternative_weights="2128.4"
                     /alternative_weights="2146.4"
                     /alternative_weights="2164.4"
                     /alternative_weights="2182.4"
                     /alternative_weights="2200.4"
     gene            12833..14617
                     /locus_tag="JIW86_RS37040"
                     /old_locus_tag="JIW86_37040"
     CDS             12833..14617
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940770.1"
                     /locus_tag="JIW86_RS37040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37040"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257558706.1"
                     /transl_table=11
                     /translation="MRSPDAAVHTPETQTVERGADRALVAAARHSGGRTAAVLGCAVTA
                     AAAALAEPAVLGHTLDLLLRKDPSGPAWTLLCAAVIAAEVVLDAAAARLTGEVDGRSTA
                     RLRRLGLARLLRTAPHHAARYAPGETAARLTAHATEAGKVPAAVAHAVAALLPPIGAVA
                     ALFLIDLWTALAFVMGVPLLVLLLRAFARDTLGSVARYQQVQLATAGRLVEALAGARTI
                     AAAGTADRERARILAQLPELGTEGRRMWQVYGGTTARSAVLMPMLLYAVLAVGGIRLSA
                     GAIGVGELLAALRYAGLAAGVGAVTGGLAAVVRGRAAARKTAALLALPVLDHGRSELPE
                     GGPGTLELRDVRVVRGGSTVLHDISLVIPGGSTVAVVGRSGSGKTLFAAVAGRLTDPDA
                     GLVLLDGVPLREVTAEALRREVGYAFDRPALLGDTVADAIGFGAGPDPGPEAVRVAARA
                     AGADLFVRRLPHGYGTCLADAPMSGGEVQRLGLARAFCHAGRLLVLDDATSSLDTVTAR
                     EVERALAHEVRPGTRIVVAHRLSSAVRADLVVWLDDGRVRAAGTHRELWQHEPDYRAVF
                     AADAKPAPEGEPATEAAR"
     gene            14614..16392
                     /locus_tag="JIW86_RS37045"
                     /old_locus_tag="JIW86_37045"
     CDS             14614..16392
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972311.1"
                     /locus_tag="JIW86_RS37045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37045"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257558707.1"
                     /transl_table=11
                     /translation="MSESEAWRRVAPEGRRFLRGRKGALGRLAAWSLLESAHTFLGGYG
                     VARALDDGFLAGRTATGLAWLAAAGAGAVLGGFALRGVFAGLADLVEPLRDGLVRRSVR
                     QALDRAVVDPARAPDAGAVSRLTQQTEMARDSFAGLVLTVRSFVFTAVGAFAGMAALAP
                     VLLLIVLPPLLLGVAAFLATLRPMASVQRLSLDTDEALSDRVAALGEGLRDIVACGGQA
                     AAEARVEPLIATQERMARRLARWAALRTLALGTAGRLPVIALLAATPWLLGHGITAGAL
                     AGGLMYVVQALLPALNSLMTALGSAGTRLLVVLERFCDPLSPAPDHGRATKPRGSVVHA
                     GRRTAAAAELRGVTFAYGPGAAPVLDALDLVVRPGEHLAVVGPSGIGKSTLTALLAGML
                     SPDAGTVLVAGAAARREPGATGPDPRRTLLPQQAYVFTGTVRENLTHLSPGPGATGPGD
                     ADAQVRRAVSALGLEDLVERLGGLDAEVSPRLLSRGESQHLALAAAYLSTAPLLLLDEA
                     TCHLDPRTEERAERALADRAGTLVVVAHRVSSAARADRVLVLDGTRAVCGTHAELPARS
                     ALYRDLVGRWNGTSDE"
     gene            complement(16427..17035)
                     /locus_tag="JIW86_RS37050"
                     /old_locus_tag="JIW86_37050"
     CDS             complement(16427..17035)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142169.1"
                     /locus_tag="JIW86_RS37050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37050"
                     /product="response regulator transcription factor"
                     /protein_id="WP_257558708.1"
                     /transl_table=11
                     /translation="MTKVLVLHSVSLVRSALAALLRSEGPFEVTSAGWRTAVRQAESLR
                     PDVTVVDLDCPGATAVLADNGRADGQVLTSPSPVLVLASIGAPGSLHRAFRAEARGYVD
                     KDGSPGRLVRAVRKVAAGERFIDASLASAFMEADPVPLSPRELSVLARAAEGDSIPEIA
                     RTLHLASGTVRNYMAAATRKTGARNLIDAIRISRRAGWV"
     misc_feature    complement(16904..16906)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17212..17661)
                     /locus_tag="JIW86_RS37055"
                     /old_locus_tag="JIW86_37055"
     CDS             complement(17212..17661)
                     /NRPS_PKS="Domain: Polyketide_cyc (9-128). E-value:
                     2.4e-14. Score: 45.6. Matches aSDomain:
                     nrpspksdomains_JIW86_RS37055_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033581.1"
                     /locus_tag="JIW86_RS37055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37055"
                     /product="SRPBCC family protein"
                     /protein_id="WP_215140443.1"
                     /transl_table=11
                     /translation="MSHVEEYVEVNVPVSTAYNQWTQFEEFPAFMEGVERIEQRTDTLT
                     HWVTNVNGVQREFDARITEQLPDRRVAWMTVGGEARQAGIVTFQPIDATTTKVVLHMNW
                     VPDGLAETAADKLGFVKRQVVGDLKRFKLFIESRGVETGAWRGEV"
     aSDomain        complement(17278..17634)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS37055_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="2.40E-14"
                     /label="JIW86_RS37055_Polyketide_cyc.1"
                     /locus_tag="JIW86_RS37055"
                     /protein_end="128"
                     /protein_start="9"
                     /score="45.6"
                     /tool="antismash"
                     /translation="VNVPVSTAYNQWTQFEEFPAFMEGVERIEQRTDTLTHWVTNVNGV
                     QREFDARITEQLPDRRVAWMTVGGEARQAGIVTFQPIDATTTKVVLHMNWVPDGLAETA
                     ADKLGFVKRQVVGDL"
     gene            17873..18307
                     /locus_tag="JIW86_RS37060"
                     /old_locus_tag="JIW86_37060"
     CDS             17873..18307
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128554.1"
                     /locus_tag="JIW86_RS37060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37060"
                     /product="VOC family protein"
                     /protein_id="WP_257558709.1"
                     /transl_table=11
                     /translation="MTVPKTSVLILDCAEPEPLARFYAELLGATAGPATGNGELFLVTG
                     RTGTVLGVRRDPHHAPPSWPLPEESQQAHLRILVAADSLDEAEREAVVLGARPVAAEED
                     GTRLDNRTTLRRFTDPAGHSFVIAAVREDPDPTPLTGWRP"
     misc_feature    17885..17898
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.72"
                     /tool="antismash"
     misc_feature    complement(17887..17902)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.18"
                     /tool="antismash"
     gene            18466..19830
                     /locus_tag="JIW86_RS37065"
                     /old_locus_tag="JIW86_37065"
     CDS             18466..19830
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.4"
                     /locus_tag="JIW86_RS37065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37065"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_257558710.1"
                     /transl_table=11
                     /translation="MKRGVRAGLAGPALVAALAGCFGPQPPMFDDGRSERVVSWRGGLP
                     VAPGADGTWVLHQDSTGIFGQGTKLARFPDRPAGEAPAAAGRRKDGEVPGWTVELPPEF
                     ALTSKVPGSPNSALSDPGSGSMVVLVGGRPGRTGPTDVARVDTEHGTLAWRHELPDGAL
                     VSYSSEGSSSVLVEAACAPDGCRVTGWDPWSGQQRWERTEPGATSVLDGCGRDALFRNA
                     HRCETYLVSGERMARVNPETGEPHWVEGLRLPEGRIDRVGLQADSRLIVVTAPAEDDCR
                     AAVVGSAVTSGTGDEGWRLDVTWDQPQSARDPETGCRWDRTVPLDAGVRLVVPDAQGAY
                     VLNPYFGTLRPVSRLAPGEYPVPDAGRTIVRAPGRADRDLNDPARPVRPSGLGPEAVVV
                     GEGFWQDGRQLYLYGRDGRMLWRTESACRANLTRHGALRYCDGGELVLLSPVARK"
     gene            20124..20855
                     /locus_tag="JIW86_RS37070"
                     /old_locus_tag="JIW86_37070"
     CDS             20124..20855
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262388.1"
                     /locus_tag="JIW86_RS37070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37070"
                     /product="hypothetical protein"
                     /protein_id="WP_257558711.1"
                     /transl_table=11
                     /translation="MSAADEGRQWPDEASVDNARTTLLQLLARTGVPSGDARQLIGLLE
                     AGALALAHEELSGGARSAPGDKGEAYEAGRLDGAGGLLEELGAIAERTLLRVVGEDGQQ
                     GPAGERPRAGRMEVERARVAVTPLYLSFTAVSELDPEVTDEVLTAVLGTMSLRQRARYA
                     GRLTEFAAAHRARLERLFAAYGPGSAIRVHGRYSLLHSATSIAVLERLVAAPQELREEW
                     DAAELPPAWLDGLMTAWNAPA"
     gene            complement(20891..21757)
                     /locus_tag="JIW86_RS37075"
                     /old_locus_tag="JIW86_37075"
     CDS             complement(20891..21757)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006130402.1"
                     /locus_tag="JIW86_RS37075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_37075"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_257558712.1"
                     /transl_table=11
                     /translation="MQIFITGGSGYIGRSTIRALTAHGIGVTALARSEHAARTVSDLGA
                     TPVAGALTDTDVLHEAARAADGVIHLGVDYAEGTADVDRAAAEALQDGVGRGPYVHTGG
                     VWVYGDTDGVVDEDAPLSPPRITAWRLENEKRVLARAATGERPVVVMPGLVYGRSGGLV
                     QSFFVEPGRTAGAVPCIGDGSNHWALVHVDDIAELYVLALNAPAGSVYAGVSGQNPALT
                     YVTRALGQAAGCPGRIDSLTLEEAVQRMGPIAEAFALDQQFSGAKARRELGWTPTRLDA
                     LAELAQG"
ORIGIN
        1 gacggccccg gacacccggc agaggccggc tacctgctgc cgcacgaggg cggcttcccg
       61 gaggacgcct tcgacgggga caacctgatc gcgatccccg acacttgtta cgccgtcgac
      121 atcgccgcac ggctgtcggt cgacccggca tcgatcgggg ccacgacaca ggtcaggggc
      181 cacggcttgc tcgccctgac cgcatgcggc cgcgaacagg ggcaccccgc gggtgcactg
      241 cccgtctgag cctccgaacc ggggcgtact ccgtgcgccc cggcccgccg gttcaacgtt
      301 caggcgctca ggtctggcat tgcttggtgg acgcgggaga ccagccgctc caggcagcgc
      361 cgtcggcccg agcatgtact cggatctcga ccttcacggg gccgcatacc cgggtcgtgc
      421 tacccacttc gacagggccg atggcctcgc cggcccggac gtaggagcga ccgctgccca
      481 ctttctccca gtgaccaccg tcgaccacac ggaagaacgc ctcgtaggag acattcagtc
      541 ccttggttcc ggtgttacgc gccttgatgt gcgccgtgat ctctcgactg gggaactcgc
      601 cgacagatcc ccgctgggca ctgatgcagc cattgatggc gacacggccg gtcgacgtac
      661 ctccgccgca cgcgattgcc gcagcgtgag cgttggccgg gatggtcagc atggtcagcg
      721 cggctgcgcc caggatcgtt ccggtacgcc tcaaatacaa cgttccatac ccttctttga
      781 gcccgtttct ctgaacagac cacggctcac cttggggtac gacgtctcac cgagtttttc
      841 gcccaaatgg gtgcaggtgg tggcgtaggt ggccggtgat gggacgggtg cgctcacgtt
      901 caaagaaaac ttcggccaga ggtgaatcct ttccggacct ccccgcctct tgtctgtgta
      961 ccggccgaac gggccggcag aaccgggagg aacacccatg atggtcgctg gcctcgtagt
     1021 gatcggagcc ctgctcgtgg gcgcgtgcag ctggcatctg atgcggcgtt acaagagccg
     1081 aagctgacca gtgcctgcgc cgggaggcgc cttccgggag tgtgtagcag atgaaccaac
     1141 gtttcacctg gccggacgag cggctgatca gggccgctca ggacggcgac gtcacttcac
     1201 tcaccaccgt cgtcatggaa tcccagcctc atgtgcgcag gttcgccata tcgctctgcg
     1261 cctcgccgca ggacgcggag gacgcggcgc aggaggcgct gatcatcctt taccggaaga
     1321 tcggcacctt gcgggccact ggcgcgcttg cctcatggat gttccggatc gtgcgcaacg
     1381 aatgcctccg gcaggtacgg ctgctcgtct cgcggagcga tgaggcgtcg gccggaccgg
     1441 acggttccgc ggaacagtcc gcggaaccgt ccgccgagga cgcggtgctg cacaggctgg
     1501 aagcggagcg gatcgcggct gcggtcagtt cccttcccag tgaccagcgg caggtcctga
     1561 tcctgcgcga cgtacagggc ctgcccggca ggaccgtcgc ccattcgctc ggtctgagca
     1621 acgccgcgat gaaatctcgg ctgcacagag cacgtgcggc actgcgccac tctctggcag
     1681 tgaccgacca agcacccgat caagccatcg cccaaccagt cggaggagac tcacgaccgt
     1741 gaacaccctg aacaccttga acaccgtgaa gcccgcgcag gccgcgaagg cccgggccat
     1801 cacacagtcc gcagggcccg agatgaactt cgccagcaag tccgtcccgc gccacctggg
     1861 gcgcggcgcc atcggattcg ggctgatcat cggctcgatc gccctggtgc ccgtcgtcgg
     1921 cccggtcacc ctgctggcgg ccccgttggc cctgatcgcc ttccgcggct gccccacctg
     1981 ctggatggtc ggcctggcgc agaccatctc ccggggccgt ctggagcgcc agtgtgtgga
     2041 cggcgtctgc acccttacca aggcgcaccc gtcagcggtg gccacggacg agccgagatc
     2101 cgacactgtg cctggtcgtg accacggtgt ggatgagcca tccggccgcc gcgccgactg
     2161 cgtaccagag caggtcgggt gggttgaagg tggaaccgag cgcgaagcgg gcgacggtac
     2221 tgcgctcgga gagctccgcc gggacgccac tgagctgtag gaactcgacc agccaactga
     2281 cggccagcgc acatccggcg gctttcaggg gtgtcacgcg gggcgcggcc aagacgacaa
     2341 gagcgaggag caggacggtg tacagggcgt ctccgccgta cttggccacg ctccccgccg
     2401 ccacggccct gagccccagc cccacgccga cgatcaccac cgcggcaccc gctgccgcca
     2461 gacgggtccg tacggggtcg gcggcggaac ggtcacgggt tccgggtatc aggggcacgg
     2521 ggtcatcctg ccggagacct ggtgctcgcc cgtgctcgcc ccgcccgctg cgagccggcc
     2581 agcctccctc caacgcgagt cggccgcttg gcgtgacgga ccggcaggtc atcgaggtca
     2641 agaccgcact ggtgctactt gccgtccagc gcctccacca gctgaggcag gttgccgccg
     2701 gccacgacga gggcaaggtg gtcgtggtag tcccggctgc tgacgatcag gccgtcgcgg
     2761 acccgcagca cctggatgtt ggcggcctcg aaggtccgcc cggtcacccg gtggtgcacc
     2821 tggtagtcga actcggcgac gaccacctcg gcgtcgtcgg tttcccggac gaccacgttc
     2881 accggggtca gctccacggg cgaacttgcg gagacttgag cgaaccgctc cctgagtgcg
     2941 gcccgcccct cgacccggcg cggaccgacc ggctcgaaga cggtctccac cacggcgtcc
     3001 tcggcgtaga gctcggccag ttccgtgaac cgtcccgcgc cgatgccctc gatcagcttc
     3061 tggaagactt cgcgcggtga cagcgtttca ggcatgccaa acctccggtg ggatccacgg
     3121 ctagaatcgg actggaaact ccgttttcac gatacggact ggagagtccg gttgtccagg
     3181 gtggctctgc cgtcgacggc gaaaggtggg acagggatgg gtggcgctca ggagcgcccg
     3241 ctgcgggctg acgcggcccg caaccgggcc aggctgctgg atgtcgccac ggaggtgttc
     3301 accacccgcg gcgtgggcgt gccgaccgag gagatcgccc ggatcgccgg ggtcggagtc
     3361 ggcacgctct tcaggcactt cccgaccaag gaggcactgc tggaggcggt gatggtgcgc
     3421 cggctggagg aaatggcagc ccggacggct cagttggccg ccgagtccgg tcccgccgaa
     3481 gccttcttcg cgtgcttccg cctggtggtg gaacagtccg aggggaaaaa cgagttcgcc
     3541 caggctctcg ctgtggccgg ggtggacgtg catgcgtccc tgcaggagcc gaccatggag
     3601 atccaggccc ggctggccga tctgctggcc ggggcacagc gggctggcgc ggtccgcccg
     3661 gagctgggcc tgccggagtt catcgccctc ctggccggca ccggcagggc gatggaacag
     3721 ctcggagtgg atccggcacc ccgggagcgg atcttcgagg tggtcttcga cggactacgg
     3781 ccacgctgaa tcgaaggcgt gcaatccgta cttgttcggg cgcaccgacg agtacgtcga
     3841 caccaaccac ttccggagac ttcaacccac gaggtcgcac cagaacgaga cggtcgcctt
     3901 gcggtcccat gcctcgtcct gacggtccaa gccaggtcca ccgaacttct acgccccgca
     3961 ggcacccgtc cttctatcac caacctgtgt tgttcctaga atggccgtgt ggaggatatc
     4021 gatgcgatcg cggtgttgca ggaccgggtg cggcggcgcc tgtatgagta cgtggccgcg
     4081 cagggccgtg aggtcggccg caacgaggcc gccgaggcgg tcggggtggc gcgcacgctc
     4141 gctgcgcacc atctggacag gctgaccgag gcggggctgc tggaaagcgg cagtcgtcgc
     4201 ctgacgggcc gctcggggcc gggggcggga cgcccggcca aggtgtacac gcgggcgcgg
     4261 gccgagtggt cggtgtcgct gcccgcccgc gactaccgca ccgccgctga gctgctcgcc
     4321 gaggccgccg agcaggccgg gctggacgcc gggctctgcg cggccgcgcg ccgtcggggt
     4381 gaggcccttc gtggctcggc ggagccctgt ggcggcctcg aagaggccat ggagatgctg
     4441 gccgcccgcg gctacgaacc gcaccttgaa ggtatcgagg gtgccgaggg ggcggccgga
     4501 cccgtcgtcc gtatgcgcaa ctgccccttt catgctgtcg ccgaacgctt cccgccgctc
     4561 gtctgcggca tgaatctcgc gctgctggag gggctgctcg gcgcggacgg ccccgtccgc
     4621 gcccgtatgg acgccaggcc gggggagtgc tgcgtggtgg tcgagacttc taaaaacaat
     4681 gatgattgac atagaaaagt gagtcgtgct gggatgggtc catgaccgca tccacgcatg
     4741 ccgcccacct cgcccaactc aacgtcgcca cactcctcta ccccttcgac gacccgcgcg
     4801 tggcgccctt cgtcgagatg ctcgatccgg tcaactccgc cgccgatggc gcgcccggtt
     4861 tcgtatggcg gctcgcggag gagggggagg ccgacgccac cggcctgcgc ccggcgggcg
     4921 aggacgtcat cgtcaacctg tcggtgtggg agacccagga ggctctgtgg gacttcgcct
     4981 accgcagcgg gcacctggag gtgatgcggc ggcgccgcga atggttcgaa cggcacgtcg
     5041 aggcgcacct ggtgctctgg tgggtccccg ccggtcacct cccgaccgcc gacgaggccc
     5101 tggagcggct ggcggacctg caggcgcacg ggccgtcccc gcgcgcgttc acctttgcct
     5161 cctcctacac cgccgccgag gccgcccagc accttcagac agtgccgccg gcgcagccag
     5221 agcaggccgc cggagcgcgc ggttgacgtc ggccggggac tcgccggcgg tctgaagcaa
     5281 ggacgttcag cccagcaggg caacgaagtc gggtgagtcc gggttccggg gttgaagttg
     5341 tcgctgcgtc agcttctacc gtcctttcca gggccggaga gaccggcccg gtgacgcact
     5401 cgtgagggag cggtgatgga ctggtccatc gcggaggtgg cccgaatctc gggcgtgacc
     5461 gcccggaccc tgcgccacta cgacgagatc ggtctcctcc cgccggcccg gatcggcgcc
     5521 aacggccacc gctactacga ggaccgccag cttctgctgc tgcagcagat cctcgtcctg
     5581 cgggcgctgg gcgtcgggct gccggagatc ggccggatcc tgtccgagca ggtcgccgag
     5641 gtggacgcgc tgcgcggcca tcaccggcgg ctgctcgcgg agcgagaccg gctcgacgcc
     5701 ctggccggca ctgtcttccg cacgatcgtc gaactggagc agtccggaaa ggacggccga
     5761 cccatgacca tcaaccgacc tgagaacctg ttcgagggcg tgcagccctc ccagtacgaa
     5821 gagaacatgc gcgacttccc cgagctcgcc gaggaggtcg gtcggcgggc ggccacgatg
     5881 agccaggccg atgccgaggc cggacaccgc gagcgcacag cgcagatgat ccggctggcc
     5941 gagctgatgg ccgccggcca ccgggccgac gccgagcccg tgcaggccga gatcggcgcc
     6001 cagtacgggg cgctcaccga gctgcgcgcc gtgtccgccg aggagtaccg cgcgatcggg
     6061 cgctcctgtg tggacaacga ggcctggcgc gccgcttacg aggcgatcac cccgggcctg
     6121 gccgcgtacc agcgggacgc catcgatgcc tacgccacgt ccaggctgag ctgacgccga
     6181 gcctgtttcg ggtcagctcg agcgctcgac gcgcgcgagc cagtcagtga ggagggcgcg
     6241 caggagttcc ggttgctcgt ggggcagggc gtgtcccgcg tcgtcggcca cggcgagcga
     6301 ggcgtgcggg tagtggtcga ccaggtcggt cgcggcggca tatccgacgg tcgagtccag
     6361 ccgccctgcc acgaccactg tcggccccgc gtaagccggc gcgtgatcgg gagtcagcgt
     6421 ccatcgttcg ccgattcgct cgagcgctgc atggtcgacg agcgcggcgg ctggggcgac
     6481 gtagcgttcg taccgttcga gcatctccgg ggtctggatc acgaagtagc tccggaagac
     6541 gtcgtcgccg atctcacccg atccggcgac gacgcggtgc tccggcacgt cgcgcagttc
     6601 tgacaacaac ggacagacga gcgccagacc ggcgacctgc gccgggcgcc tcgcggccat
     6661 cgcctgcgcg tagtacgcgc ccgccgagtg gccgacaagg aggtgcgcgc tcccgccagt
     6721 gacctcgtcg gcgaagtcga gcagcgtgtc gagcacgtcg tcggcgctgc gcagcgttcc
     6781 gggagcgact gtccggccca ttccgggaag gtcgggatag atccgccgca gccccgcaac
     6841 gccgtcgaaa gccagctcga agcaagcctc ggcctcgcgg tggtcgacgc cggcgccatg
     6901 gagtaccagt acgggtcgac cggtcccgta ctccacgtag tggaccacca cctggcccac
     6961 tcggatctcc atccccgcag gctacccgcg caggggcgac tgaaggatga gtacgtgccg
     7021 acggcgttct cgaacccacc cgatttctac aaaatgttga cgcgcctcta tcggaaatcc
     7081 cgccgcctga cggacgatcc aggtaccctc cccgcttttc gtctgacgtc tcgtcggcgc
     7141 agggaagggc gagcccaccc cggccgttgg gaggcaacac gacatggacc cgctccgtga
     7201 atgtcccggc accgcctcag acgcagcgca tgcagcgcat acagccccgc accctgatcc
     7261 ccggcccgcg ccgcccagcc gccgcggcgt actggctggc ctgggcatgg ccgcggccgt
     7321 gcccttggtc ctcggcgccg gtcgtacgca gccgcgaggg ggaaccccga cgggccgggc
     7381 tgcggtgctc aggaacgccg cactcgtgct caccatggac cgcgccctcg gcgaaggccc
     7441 gctgggcgcc gtggagcagg cggacgtcct catgcgcgac ggtctcatct cggcagtcgg
     7501 caagcggctg ccggccccgc ccggcaccca ggtgatcgat gccgccggga agctggtgat
     7561 gccggggttc gtggacgtcc acacgcacct gtggcagtcg tcgatgcgag gcggctgcgc
     7621 ggaccgtgac ctcttcggat ggctggccga ctgcaattgg cggacgttct cccggatcgc
     7681 accggcggac atgtaccgct tcgtccgcct cggcgccctc gactccctgc agtccggtgt
     7741 gaccacgctc gtggactggg tggacgccat cccgtacgac accacggtcc agtacgtacg
     7801 ggccctggcc gatacggggg tgcgcttcgc ctacgccatg ttccaggccg agcgggatgc
     7861 caccctgatc acccgggcga agcgggaact catcgacccg gtgccgctcg cctcggcgca
     7921 ggtcgccacg cacgcggcgc gggccatcca gggcctcaac cgagttcact gggagatcgc
     7981 ccaggatctc ggcgttatgc tcaacagcca tgtcctcgaa cgcagcgaac agcgggcgga
     8041 cgacccgatc ggcaccctga cggacatcgg cgcgctgggc ccccggctgc tgatgaacca
     8101 cgcgatccac ctgaccgacg acgagctggc cgctgtcgcc tcgcacgacg tgagggtctc
     8161 gcactgcccg ctcagcaaca tgcggctcgc ctcggggatc atgcggctgc cggacttcgg
     8221 ccgacggggt gtcaaggtcg ggctcggcca ggacggcggc accaacgaca cctcggactt
     8281 cttcgccctc atgaagacgg ccgtcggcct gcagcgggtt cgcgcccagg agacgtcggt
     8341 gttcccccag atccacgacg tgctgcggat cgccacgctc ggcggagccg aagcgatcgg
     8401 catggccgac accgtcgggt cgttgacgcc cggcaagagc gccgatgtca tcgtgatcga
     8461 cccggccgcc ctcaacttcg cgcctcggtt cgactggatc aaccagatcg tgctcaacgg
     8521 ccgaccggag aacgtccacg cggtcttcgt gaacggccgg ccgctcaaac tcaacggacg
     8581 cctcgtcgac gtggaccccg gtcgggtcgt acacgaagcg gaagccgcgg ccgcgcgact
     8641 tcgggccgtc tcctgaaccc gattccccgg gtcaggccat cagggagagt tcggtccggt
     8701 tcggtccggt ccggtgcggc gatgtaaatg gcaaatctcc ttacggctga cgtgtccgcg
     8761 acgacaatga gggcttcggg tgtggctacg gggggacggc gcatggtcga gcaggtatta
     8821 gcgatcttca ctcagatggc cggaggaacg gccgcggtgg tcggggcgga agtgggccat
     8881 gccgtctcga ccatcgtgcg cgatcgtctg ggaacgaccg aacagggtcg cgcggcgatc
     8941 agcaccgtgg agaccagccc caccgacccg gcggccgtcg agcaattgcg ggacatcgtc
     9001 gagtcggaga tggccgccga tccgcgcttc gccgagcgga ttgccctggc cctcgcgggt
     9061 ccgcctcccg catccgcgcc tcgcatcaac acgggcattt cgttcgacaa cagcccggta
     9121 cggggccgcc ccatcatttc catggccgga gtgacggtca gcaatacccg caacgttcgt
     9181 ttctccctgc tcgccgcggc tctcgtgctg gtcgcgctgc ttgccttggg cctctacggc
     9241 ggcacgcagc tcttcaacgg cgacgattcc ccggcacagg gtggagccgg gtccccaaag
     9301 tccgccacgg ccatcaagga cgcggcgctg gccaagacga tccctcccgg tatggacagc
     9361 ctgccgaccg gctggagtgt cggctcgggc tatcccaagg agtttcgctg cgggggaatg
     9421 cccgcgaagt gccgagacgc gctgctcgac atccagacgt cctacacccc gggcttctac
     9481 ttcgatcagg cacagatcga agtggtgacc tatccgagcg ttgaagcggc gaccgccgga
     9541 tacgccgaaa tcaaacgaga aaacgcggac ttcggatcca ccccgacgcc ggtggccatg
     9601 tcgaacgcgg gcggagacga gtccgccgca gtcgaatggg ccaacagtcc gacgcccggc
     9661 attaccgagg cgaccggcgc gttcgcggtc gtcagggtgg ggacggtcgt catcaatgtc
     9721 gtcatgatgg acgagggcgc cggcggcaca gacctcggca tcctccagtc cttcgccgcg
     9781 accgcgaccg cccgcgccca gcagacacag aacggtcagg ctcccagcgc cgtcatgacg
     9841 cgctaggcag cggtgccaag ccggtgccaa gcgggtgtca tccggtgagg aatccctcgt
     9901 gactcgtgag tactgcacac cccgtcagtg acagcggtga ctgtcgccgc gtccgccggg
     9961 cgtgacacgg tcgggtctgc caccgaccga gggagcaggt gtgaacaagg ggtacgccgc
    10021 cttctgcgac tccgaccgct ggttctacga cgcgccgtac cggcgggtcg gtgagagcta
    10081 cgcggccgcc ctcgcccccg tcccgccggg gtggcgctcg caccggagcg gcgactggct
    10141 cgcgctgcgt cccgtcggcg ccgaactgcc cgcgcagggc tggaagatcc acgtctcggc
    10201 cacgctcgac aacgccgagt cggtgctgac gacggtgtac gagtactgca cctcccgagg
    10261 catcgccttc aagttcatac cgagccggta cctgttacac ctgcgcaacg ccaagtacgc
    10321 cgaccgcgcg gcgagcggga agttcatcac cgtctacccg gccgacgagc agcagtgcgg
    10381 ccggatcgcg gaggacctcg acgcctcgct ggcgggagcg gccggcccgt acatcctcag
    10441 cgatctgcgc tgggccgccg gaccggtcca cctgcgctac ggcagtttca ccctgcggca
    10501 ctgctacgac gagcacggcg cactggtccc ggccatagag gcccccgacg ggcggctcgt
    10561 accggaccgg cgcggaccgg ccttccagcc gcccgagtgg ctcgaactgc ccgacttcct
    10621 gaagccgcat ctcgcagcgc gctccgcggt caccctgacc ggcgtcccct tcacggtgga
    10681 gcgggcgctg cacttctcca acggcggcgg cgtctacctc gggaaggaca gccgcaccgg
    10741 cgaggccgtg gtcctcaagg aggcccggcc gtacgccggg ctcgccgccg acggcgccga
    10801 cgccgtgacc cggctgcacc gcgaacaggc cgcactggaa cggctgacgg gcctgggctg
    10861 cgtcccggag gtccggggca cgttcaccgt cggcgaccac cacttcctgg tgctggaaca
    10921 cctcgccggc aaaccgctca acacctactt cgcccgccgc cacccgctga tcgaggcaga
    10981 tcccgacccg gcggagctcg cctcgtacac cgagtgggcc ctcaccatcc accggcgggt
    11041 cacggaggcc gtcgacgccg tgcacgcccg cggcgtggtc ttcaacgacc tccacctctt
    11101 caacatcatg gtggcggagg acgagacggg cgaaccctcc gtcgcgctgc tggacttcga
    11161 agccgccgcg cacgtagacg aggggctgcg gcagaccgtg gccaaccccg ccttcgtcgc
    11221 accggccgag cgccgcgggt tctccgtcga ccgctacgcc cttgcctgcc tgcggctcgc
    11281 cctgttcctc ccgttgacca gcctgctcgt cctggaccgg gccaaggccg cacacctggc
    11341 ggccgtggct gccgaacagt tccccgtgcc gcggcggttc ctcgacgagg ccgtcgagga
    11401 gatcctgtcc ggcgtcccgc agggcgcacc gggcgaccgc gtgcccgcac cggccgggcc
    11461 gtacctgccc gtcgagccac gggaatggcc ggccgcccgt acgtcgatga ccgcggcgct
    11521 gcgcgcgagt gccaccccgg accgcgagga ccgcctcgtc ccgggcgaca tcgcccagtt
    11581 cgcgaccgcc gggggaggga tcggcttcgg ctacggggtc gccggagtgc tccacgccct
    11641 cgccgagacc ggtgccgaac cctggcccga ggccgaggaa tggctcctcg accgcaccgc
    11701 ggaaccggct tccggcactc cgctcggctt ctacgacggc ctggccggca cggcctggac
    11761 gctgcaccgg ctcggacacc acgaccgtgc cctcgccctc gccgacctgc tgctgcacca
    11821 gccgtgggag agcgcgggcc ccgacctgca cagcggactc gccggcatcg gcctcgccct
    11881 ggacgcgctc ggcaccgcga gcggcgagag cgagctgcac gctgcggccc tgcgctgcgc
    11941 cgaactgatc gcccggccgg agcatcggcc cacccgcgcg ggactgctgt acggcaactc
    12001 cggccccgcc ctgctcctcg tgcggctgta cgagcgcacc ggcgacaagg aactgctgat
    12061 ccaggccgcc cacgcgctcc accgcgacct cgaccgctgc gtcaccagcg cgtacggcac
    12121 cctccaggtg aacgagggct ggcgcaccat gccgtacctc ggcgagggca gcgtcggcat
    12181 cggcatggtg ctcgacgact ggctggagca cggtcccgac gagcgcttcg aacaggcccg
    12241 gcgcgagatc gtacgagcgg cgcaggcgac cttctacgcc cagcccgggc tgctgcgcgg
    12301 cgccgccggg atgatcctcc acctggcccg gaccaccacg ccgggcccgg gaaccggccc
    12361 ccaagccatc gcccgccaga tcgacgcact ggcccggcac gccgtgccgt accaggggca
    12421 tctggccttc ccgggcgagc agatgatgcg gctgtccatg gacctcgcca cgggcacggc
    12481 cggcgctctc ctcgccctcg gcagcgcggc gcccggcggg cgcgcgcacc tgccgttcct
    12541 cccgccgctg cgcgagcgcg gcgcccccaa gccggtccca cccggggccg tgacccatcg
    12601 caccactcga gagaagaaga ggaaccgaca tgacgcttct tgacctgcag tcgatggaga
    12661 ccccgaagga agagtccacc gaggccgcga tgacgggcgg cggcagccgg gccagcctgc
    12721 tgctctgcgg tgacagcagc ctgagcctca cgacctgtca ctgattcagg tcacctcggg
    12781 cccgggcggt tcgccgcccg ggcccgcacc acatcactgg aggcatccgc cgatgaggtc
    12841 ccccgacgcg gcggtccaca cacccgagac gcagaccgtg gaacgcggcg ccgaccgggc
    12901 gctcgtggca gcggcgcggc acagcggcgg gcgcaccgcc gccgtcctcg gatgcgcggt
    12961 gacggccgcc gcggcagcac tcgcagaacc cgccgtcctc ggccacaccc tcgacctgct
    13021 gctccgcaaa gacccgtcgg gccccgcctg gacactgctg tgcgccgcgg tcatcgcggc
    13081 cgaagtggtg ctggacgccg ccgccgcacg gctgaccggt gaggtggacg gccgctccac
    13141 cgcccgactg cgcaggctgg ggctggcccg gctgctgcgg acggctccgc accatgcggc
    13201 gcgctacgca cccggcgaaa ccgccgcgcg actgaccgca cacgccaccg aggccgggaa
    13261 ggtcccggcc gccgtcgcgc acgccgtcgc cgcactgctg ccgccgatcg gcgcggtggc
    13321 cgcgctcttc ctcatcgacc tgtggacggc gctcgccttc gtcatgggcg ttccgttgct
    13381 ggtgctcctg ctgcgggcct tcgcccgcga caccctcggc agtgtcgccc gctaccagca
    13441 ggtgcagctc gcgaccgccg gccgcctcgt cgaggcactg gccggggcgc gcacgatcgc
    13501 cgccgccggc accgccgacc gcgaacgcgc gcggatcctc gcgcagttgc cggagctcgg
    13561 caccgagggc aggcgaatgt ggcaggtcta cggtggcacg acggcccgct ccgcggtcct
    13621 catgccgatg ctcctgtacg cggtgctcgc cgtcggcggc atacgcctgt cggccggggc
    13681 catcggggtc ggcgaactcc tcgccgcctt gcggtacgcc ggcctcgcgg ccggggtcgg
    13741 cgccgtgacc ggcggactgg ccgccgtggt ccggggccgg gcggccgccc ggaagaccgc
    13801 cgccctcctg gctctgcccg tcctcgacca cggccggtcg gagctgccgg aaggcggccc
    13861 cggcaccctg gaactgcgcg acgtccgggt cgtacgcggc ggatcgacgg tcctgcacga
    13921 catcagcctg gtgatccccg gaggcagcac agtggcggtg gtgggccgct ccggctccgg
    13981 caagacgctg ttcgccgccg tggccggccg gctcaccgac cccgatgcgg gcctggtcct
    14041 gctggacggc gtacccctgc gggaggtgac cgccgaagcg ctgcgccgcg aggtcgggta
    14101 cgccttcgac cggcccgcgc tgctcgggga cacggtcgcc gacgcgatcg ggttcggagc
    14161 cggtcccgac cccggcccgg aagcggtccg cgtcgcggcc cgggccgccg gcgccgacct
    14221 gttcgtacgg cgcctgcccc acgggtacgg cacgtgcctc gccgacgccc cgatgtccgg
    14281 cggtgaggtc caacgcctcg ggctggcccg ggcgttctgc cacgcgggcc ggctcctcgt
    14341 gctggacgac gccacctcca gcctcgacac cgtcacggcc cgcgaggtcg agcgggcgct
    14401 cgcccacgag gtccggcccg gcacgcggat cgtggtcgcg caccgcctct cctccgccgt
    14461 ccgcgccgac ctcgtcgtat ggctcgacga cgggcgggtg cgggcggccg gcacccaccg
    14521 cgagctgtgg cagcacgagc ccgactaccg ggcggtgttc gccgccgacg cgaagccggc
    14581 acccgaaggg gaaccggcaa cggaggcggc ccgatgagcg aaagcgaggc ctggcgtcgg
    14641 gtcgcccccg agggccgacg gttcctgcgt ggccgcaagg gcgctttggg gcggctggcg
    14701 gcatggtccc tcctcgagtc cgcgcacacg ttcctcggcg gctacggcgt ggcccgcgcc
    14761 cttgacgacg gcttcctcgc aggccgtacc gccaccggtc tcgcctggct ggccgcagcc
    14821 ggagccggag cagtgctcgg cgggttcgcg ctccgcggtg tgttcgccgg actcgcggac
    14881 ctcgtggagc cgctgcgcga cggcctggtg cggcggtcgg tacggcaggc actggaccgc
    14941 gcggtcgtcg acccggcgcg cgctcccgac gcgggcgcgg tgtcccggct gacccagcag
    15001 acggaaatgg cccgggactc cttcgccggg ctggtactga cggtgcgttc gttcgtgttc
    15061 accgccgtgg gcgcgttcgc gggcatggcg gccctggctc ccgtgctgct gctgatcgtg
    15121 ctgcccccgc tgctgctggg cgtggccgcc ttcctggcca cgctccgacc catggcatcc
    15181 gtacaacgcc tgtccctgga caccgacgag gcgctgtcgg accgggtggc ggcgctgggg
    15241 gagggcctgc gcgacatcgt cgcctgcggt ggacaggctg cggcggaagc ccgggtcgag
    15301 cccctgatcg ccacccagga gcggatggcc cgcaggctcg cgcgctgggc ggccctgcgc
    15361 acgctggccc tgggtacggc gggccggctg cccgtgatcg cactgctcgc cgcgacgccc
    15421 tggctgctcg ggcacggaat caccgccggt gcgctggccg gcggcctcat gtacgtggtg
    15481 caggcgttgc tgccggctct gaactccctg atgacggcac tgggttccgc aggcacccgc
    15541 ctcctggtgg tgctcgaacg cttctgcgac ccgttgtcgc cggccccgga ccacggccgc
    15601 gcgacgaagc cgcgggggag cgtcgtccac gccggccggc ggaccgccgc cgcagccgag
    15661 ctccggggcg tcacctttgc ctacggcccc ggggcggctc ccgtactcga cgccctagac
    15721 ctggtggtgc ggccggggga gcacctcgcc gtggtcgggc cgagcggcat cggcaagtcc
    15781 acgctcaccg cgctgctcgc cgggatgctg tcacccgacg cgggtacggt cctcgtcgcc
    15841 ggtgcggccg cccgccggga accgggtgcg acgggaccgg acccgcggcg gaccctgctg
    15901 ccgcagcagg cctacgtgtt caccggcacc gtgcgggaga acctgacgca tctgtccccg
    15961 ggccctgggg ccaccgggcc cggggatgcg gatgcccagg tgcggcgcgc cgtcagcgcc
    16021 ctggggctgg aagacctggt ggaacggctg ggcggcctgg acgccgaggt gtccccccga
    16081 ctgctgtccc ggggcgagag ccagcacctg gcactcgccg ccgcctacct ctcgacggcc
    16141 ccgctgctgc tgctcgacga ggccacctgc cacctggacc cgcgcacgga ggagcgtgcc
    16201 gaacgggccc tcgcggaccg ggccggcacg ctcgtcgtcg tggcccaccg cgtctcgtcc
    16261 gctgcccgcg ccgaccgggt cctcgtcctc gacgggaccc gggccgtgtg cggcacgcat
    16321 gcggaactcc cggccaggtc ggccctgtac cgcgatctgg tggggaggtg gaacggcacc
    16381 tcggacgagt gacgcgcctg ccgtgcccgg ccgcggcggc cgccgatcag acccagcccg
    16441 cccgccggga aatacggatc gcgtcgatga gattgcgggc accggtctta cgggtcgccg
    16501 cggccatgta gttgcgtacc gtcccgctcg ccaggtgcag tgtgcgtgcg atctcgggga
    16561 tggaatcgcc ctccgcggcc cgggccagca cactgagttc ccgagggctc agcggtacgg
    16621 ggtcggcctc catgaaggcg gaagccagcg aggcgtcgat gaaccgttcc cccgcggcca
    16681 ccttccggac cgcccgtacc agccgtcccg gcgagccgtc cttgtcgaca tagccgcggg
    16741 cctcggcccg gaaggcccgg tgcagggaac cgggtgcgcc gatcgaggcg agtaccagga
    16801 ccggagacgg ggacgtgagg acctggccgt ccgcgcgtcc gttgtcggcc aggacggccg
    16861 tcgcccccgg acagtcgagg tcgacgaccg tcacgtctgg tcgtaaggac tcggcctggc
    16921 gtaccgcggt ccgccagcct gccgatgtga cctcgaaggg cccttccgat ctcagcaggg
    16981 cggccagtgc cgatcggacc aggctgacac tgtgcaggac gaggaccttc gtcatcgtgt
    17041 gctctcctcg gttgacgaac caacggcacc acacgggtgc ccccgtacag gggtgatgga
    17101 acgtcactgc ggggggcgcg gaggggcgta cggacaactt ggccgagata cccagggatt
    17161 tcgctaccct taggcgggtt acccccttga gagcggcgcc gtcccgcgct gtcagacctc
    17221 gccgcgccag gcgcccgtct cgaccccacg cgactcgatg aacagcttga accgcttcag
    17281 atcacccacc acctgccgct tgacgaagcc gagcttgtcg gcggccgttt cggccaggcc
    17341 gtcgggcacc cagttcatgt gcaggacgac tttggtggtg gtcgcgtcga tcggctggaa
    17401 ggtgactatc ccggcctggc gggcctcccc gccgaccgtc atccacgcga cgcgccgatc
    17461 cgggagctgc tcggtgatcc gtgcgtcgaa ctcgcgctgg acaccgttca cgttcgtcac
    17521 ccagtgggtg agcgtgtccg tgcgctgctc gatgcgttcg accccctcca tgaaggcggg
    17581 gaactcctcg aactgcgtcc actggttgta ggccgtgctc acggggacgt tgacctcgac
    17641 atactcctcg acgtgcgaca tgcgcacccc tttcgtgtcg tcggcagccc cgcaccctga
    17701 ggtgcgggtc gtccgtcagg acgtctcgag gcgcggttgc ccgcccctga gggccacatg
    17761 cgcgggggac gccgacgatc ggaaggtgct gcaccgtacg ggaggagccg gccaaccggc
    17821 tcgcgggccg tacggtgcgt gtacgggcga cgacgcaggg cacacgcggt ccatgacggt
    17881 ccccaagaca agcgttctca tcctggactg cgccgaaccc gagcctctgg cacggttcta
    17941 cgcggaactg ctcggcgcca cggcgggtcc ggcgaccggc aacggggagc tgttcctcgt
    18001 caccggccgc accggcacgg tgctcggcgt ccgccgcgat ccccatcacg cgccgccgag
    18061 ctggccgctg ccggaggagt cccaacaggc ccatctgcgg atcctggtgg cggcggactc
    18121 cctcgacgaa gccgagcgag aggccgtggt cctcggggcg cgcccggtgg cggcggagga
    18181 ggacggcacc cggctggaca accgcacgac gctgcgccgg ttcaccgacc ccgcggggca
    18241 ctcgttcgtc attgcggccg tacgggagga cccggacccc accccgctca caggatggcg
    18301 gccatgacgg accaaacgcc ccggcttgct gccactcaaa tggccgccgt tcacgggagg
    18361 ttttgagcta ctcgatctct catccgtcac gattcggcgg cccggaccgg tgggaggcag
    18421 ggcacggctt acggtggtcc ctcgtgtacg gcggggggag ccgtggtgaa gcgaggtgtc
    18481 cgtgcggggc tggcagggcc ggcgctcgtc gccgccctgg cgggatgttt cggaccgcag
    18541 ccgccgatgt tcgacgacgg caggtccgag cgggtcgtgt cctggcgcgg cggactgccg
    18601 gtggcgccgg gcgcggacgg cacctgggtc ctgcaccagg actccaccgg catcttcggg
    18661 cagggaacga agctggcccg tttccccgac cggccggccg gtgaggcgcc agccgctgcc
    18721 ggtaggcgca aggacggcga agttccgggc tggaccgtcg agttgccgcc tgagttcgca
    18781 ctcacctcga aggtccccgg gtcaccgaac tcggccctct ccgaccccgg cagcggctcc
    18841 atggtggtgc tggtcggagg ccgccccggc cggacggggc ccacggacgt ggctcgcgtc
    18901 gacaccgagc acggaaccct cgcctggcgg cacgaactgc cggacggcgc cctggtctcc
    18961 tactccagcg agggctcgag ctcagtgctc gtggaggccg cctgcgcccc ggacggctgc
    19021 cgggtcacgg ggtgggaccc gtggtcaggg cagcaacggt gggagcgtac ggagccggga
    19081 gccacgtcgg tactggacgg ctgcggccgc gacgccctct tccgtaatgc ccaccggtgc
    19141 gagacctacc tggtgtcggg cgagcggatg gcccgggtga acccggagac gggcgaaccg
    19201 cactgggtgg aagggctgcg cttgcccgag ggccggatcg accgggtggg tctccaggcc
    19261 gacagccgat tgatcgtggt gaccgcgccg gccgaggacg actgccgggc cgcggtggtg
    19321 gggagcgccg tcacctccgg gacgggtgac gagggctggc gccttgacgt cacctgggat
    19381 cagccccaat ccgcccgtga cccggagacc ggatgccgct gggaccgtac agtgccgctc
    19441 gacgccgggg tcaggcttgt ggtcccggat gcccaggggg cgtacgtcct caacccgtac
    19501 ttcggcacct tgcgacccgt ttcgcgcctg gccccgggcg aatacccggt ccccgacgcg
    19561 gggcggacga tcgttcgcgc gcccggacgg gccgaccgcg acctgaacga cccggcccgt
    19621 ccggtgcgcc cgtccggcct cggacccgag gccgttgtgg tcggcgaggg cttctggcag
    19681 gacgggcggc agctgtacct gtacggccgg gacggccgga tgctgtggcg aaccgagtcc
    19741 gcgtgccggg cgaacctcac tcggcacggc gcactgcgct actgcgacgg gggcgaactc
    19801 gtcctcctca gcccggtcgc ccgcaagtga ccgacgggtc cgtgtcccag agctacctgc
    19861 ccaccccagc aggtcccagg tctcgtccac gcgggtaaca acgcatgacg tccgcgcgcg
    19921 gctacgacgg tcggctgcag ctccgtgtcc tgggctgctt ggatgccagt ggtcagcgcg
    19981 cgagggtagg ccggtgggtg gagatcagta ccgacacctg ggctgcggcg ccggggagca
    20041 cagcccggcc gtcgggcgtt ggaccatgga agggagcgat ctcgttggac acactgcact
    20101 acccgagcga tgaagaggat ctgatgagcg cggctgacga gggacggcag tggccggacg
    20161 aggccagtgt cgacaacgcg aggacgacgc tgctgcagct cctcgcgcgg acgggggtcc
    20221 cttccggtga tgcgcggcaa ctgatcggtc tcctggaggc gggagcactg gctctcgcgc
    20281 acgaggagct gagcggcggc gcccggagcg cgccggggga caagggcgag gcgtacgagg
    20341 cgggccggct cgacggcgcc gggggcctcc tggaggagct cggcgccatc gccgagcgga
    20401 ccctgctgcg ggtcgtgggg gaagacgggc agcagggccc ggccggggag cgtccgcggg
    20461 ccgggcgtat ggaggtggag cgggcgcggg tggcggtcac acctctgtac ctgtcgttca
    20521 ccgcggtctc ggagttggat ccggaggtga ccgacgaggt gctcaccgcg gtcctcggta
    20581 cgatgagcct ccggcagcgg gccaggtacg ccgggcggct gacggagttc gccgcggccc
    20641 accgggccag gctggagcgg ctgttcgcgg cgtacggacc gggcagcgcc atcagggtgc
    20701 acggccgcta ttcgctcctc cactccgcca cgagcatcgc cgtgctggag cggctcgtcg
    20761 ccgcgccgca ggagctgcgc gaggagtggg acgccgcgga gctgccgccg gcgtggctgg
    20821 acgggctcat gacggcctgg aacgccccgg cctgacctcg tccggggcag gcaccgcttg
    20881 ccctgctggt tcagccctgg gccagttcgg ccaaggcatc gaggcgggtg ggcgtccagc
    20941 cgagctcgcg gcgcgccttg gcgccactga actgctggtc gagggcgaac gcctcggcga
    21001 tcgggcccat tcgctgcact gcctcctcga gggtcaggga gtcgatcctc ccggggcacc
    21061 cggcggcctg gccgagggct cgggtgacgt acgtcagcgc agggttctgg ccgctgaccc
    21121 cggcgtagac agaaccggcc ggggcgttca gggccaggac gtacagctcg gcgatgtcgt
    21181 cgacgtggac cagcgcccag tggttggagc cgtcgccgat gcagggcacg gcacctgcgg
    21241 tccgtcccgg ctcgacgaag aacgactgca ccagtccgcc ggagcggccg tagaccagcc
    21301 ccggcatcac caccaccggg cgctctccgg tggcggcccg ggcgagcacc cgcttctcgt
    21361 tctccagccg ccaagcggtg atgcgcggcg ggctcagcgg agcgtcctcg tcgacgaccc
    21421 cgtcggtgtc gccgtacacc cacaccccgc ccgtgtgcac ataggggccc cttcccacgc
    21481 cgtcctgcag cgcctccgcc gctgcgcggt cgacgtccgc ggtgccctcg gcgtagtcca
    21541 ccccgaggtg gatgaccccg tcggccgcgc gggccgcctc atggaggaca tcggtgtcgg
    21601 tgagcgcccc cgcgaccggg gtggcaccaa ggtccgacac ggtgcgcgcc gcgtgctcgc
    21661 tgcgcgccag cgccgtcacg ccgatgccgt gcgcggtcag tgcccggatg gtggagcggc
    21721 cgatgtagcc ggagccacct gtgatgaaga tctgcatcgc actcacggtc cttgtcgatc
    21781 gagggcggcg ggggattccg ccgctcctcc accctggccc cgcgcggagg ccggcgtcca
    21841 agacctcttc tgtcagcggt gatgtcccca gggcatcagt actgggcagc ggcgatgtcg
    21901 acgaactccg ggagcagagg ggagcggcgg ccggcgctcc aggcaaggca gacctcgccc
    21961 gggccgatgt cgtcgatggg caggtgcgcg acatcggtat gggtgtagta ggcggcggtg
    22021 gacaggggaa ggacgaggac gcccccggag gtcgcgacgt gttccagctt ctcctcgacg
    22081 gtggcgaacg agggcggcgg cccggccccc tcgccaccgg aacgctcggg aaggtcacgc
    22141 cactcgggga cggcgtcggg gtcctgcagc agccgctcgg gcgccagatc cgcgatgacg
    22201 atggactcct tgcccgccag ccggtggtcc gccggcagta cggcgacacg gggctcccgg
    22261 aagagcgggc gcagctccag gccgcgacgc tcgacgggca gccgtacgaa gctcacgtcg
    22321 agaaggccct cgtgcacccc ttggacctgg tcgccccagg aagtgcgcac cacctgcaca
    22381 ctcagctcgg gatgcctggc ggagaaggcg cgcaccgcgc cggtcacggt gatcccgggc
    22441 atgaatccga ccgtgaacgc cgaagatccg tgggtggcct gctggacccg gcggcgcaga
    22501 gcctgcgcgg tggccagcag ggggcgcgcg tcctcaagca gttgacggcc ggcggccgtc
    22561 aactcggtgg tctgcttgtt cctggtgaac agttgcgcgc ccagctcctg ctccagcgcg
    22621 cggatctgcc gggacagcac cgg
//
