LOCUS       NZ_CP102509            20654 bp    DNA     linear   CON 06-JAN-2024
DEFINITION  Streptomyces sp. NBC_00162 chromosome, complete genome.
ACCESSION   NZ_CP102509
VERSION     NZ_CP102509.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NBC_00162
  ORGANISM  Streptomyces sp. NBC_00162
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8635149)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Joergensen,T.S., Klitgaard,A.,
            Mourched,A.-S., Blin,K., Larsen,T.O., Weber,T., Gotfredsen,C.H. and
            Charusanti,P.
  TITLE     Identification of the biosynthetic gene cluster for pyracrimycin A
            and elucidation of a key reaction during its biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8635149)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/05/2024 18:03:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,275
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,805
            CDSs (with protein)               :: 7,805
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 371
            CDSs (without protein)            :: 370
            Pseudo Genes (ambiguous residues) :: 0 of 371
            Pseudo Genes (frameshifted)       :: 186 of 371
            Pseudo Genes (incomplete)         :: 231 of 371
            Pseudo Genes (internal stop)      :: 27 of 371
            Pseudo Genes (multiple problems)  :: 68 of 371
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:41:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5004631
            Orig. end                         :: 5025285
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20654
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="26"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20654
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20654
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10654](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10654)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(292..306)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.63"
                     /tool="antismash"
     gene            449..2185
                     /locus_tag="JIW86_RS23395"
                     /old_locus_tag="JIW86_23395"
     CDS             449..2185
                     /NRPS_PKS="Domain: AMP-binding (17-449). E-value: 5.8e-92.
                     Score: 300.3. Matches aSDomain:
                     nrpspksdomains_JIW86_RS23395_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007264675.1"
                     /locus_tag="JIW86_RS23395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23395"
                     /product="AMP-dependent synthetase/ligase"
                     /protein_id="WP_257555791.1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-90, bitscore:
                     302.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVDGRPSTLAQFTQWTEERYGPEIALRFRAPGDGGWQTRTYGEL
                     GAEVRAVGRALLGMGVAAGERVAVLAETRPQWTYTHFGVLAAGAVLVPVYPTAGEEELA
                     WVLADSEAVVVVCDDAAQAQRVEALRAELPALRAVVGMDALPSLPQAPEAELLARAAAV
                     APGADASIVYTSGTTGLPKGCRLTHGNLGAIQDATLPLIRGGPGDSTYLYLPLAHLLAQ
                     LIQFSTLLEGGELCYFGGRIEDVLAELAVVRPTHLPSVPRLFEKLHSVVLSLAEAREGG
                     RERLEEAVRLGVLAAEGRLPESRREEYEAAEKSLYSLVRGAFGGRLKWALTGGAPIAPA
                     TLDLLRACGIAVYEGYGMTESGGVISLNHPDAVRYGTVGRPIAGCEVRIAEDGEVLARG
                     AMVFPGYHANEKATAEALDPEGWLHTGDLGELDAEGYLRITGRKKEIVITSAGKNLTPT
                     EVEFAIQRSRYVSRAVMIGDRRPHPVALITLDAEEIGAWAAREGHDLGAAPSTHPAVRA
                     LIEAAVTEANATVSRPARIRAFHVLPEDFTIASGTLTPTLKLRRRAVAERYAGEIEGLY
                     GG"
     aSDomain        500..1795
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS23395_AMP-binding.1"
                     /evalue="5.80E-92"
                     /label="JIW86_RS23395_AMP-binding.1"
                     /locus_tag="JIW86_RS23395"
                     /protein_end="449"
                     /protein_start="17"
                     /score="300.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EERYGPEIALRFRAPGDGGWQTRTYGELGAEVRAVGRALLGMGVA
                     AGERVAVLAETRPQWTYTHFGVLAAGAVLVPVYPTAGEEELAWVLADSEAVVVVCDDAA
                     QAQRVEALRAELPALRAVVGMDALPSLPQAPEAELLARAAAVAPGADASIVYTSGTTGL
                     PKGCRLTHGNLGAIQDATLPLIRGGPGDSTYLYLPLAHLLAQLIQFSTLLEGGELCYFG
                     GRIEDVLAELAVVRPTHLPSVPRLFEKLHSVVLSLAEAREGGRERLEEAVRLGVLAAEG
                     RLPESRREEYEAAEKSLYSLVRGAFGGRLKWALTGGAPIAPATLDLLRACGIAVYEGYG
                     MTESGGVISLNHPDAVRYGTVGRPIAGCEVRIAEDGEVLARGAMVFPGYHANEKATAEA
                     LDPEGWLHTGDLGELDAEGYLRITGRKKEIVIT"
     CDS_motif       953..1012
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIW86_RS23395_0001"
                     /evalue="1.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="JIW86_RS23395"
                     /protein_end="188"
                     /protein_start="168"
                     /score="21.0"
                     /tool="antismash"
                     /translation="ASIVYTSGTTGLPKGCRLTH"
     gene            2247..3092
                     /locus_tag="JIW86_RS23400"
                     /old_locus_tag="JIW86_23400"
     CDS             2247..3092
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265753.1"
                     /locus_tag="JIW86_RS23400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23400"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_257555792.1"
                     /transl_table=11
                     /translation="MPVDKRTVVTVVLCAAAALGASAAVAELVPPPEGVAPVRAKAAPT
                     GSATAPSRSQAAKPQLSTPPKSTLPPAVTPQPGGPAAFTGALFTDGLDSDHFCTATVVQ
                     SPGRNLIVTAGHCLLDGDQGGGTAVFAPAYANGVAPYGTWKLEEAFEDDRWAEGTDDSY
                     DLAFARLAPDATGRSIEDVTGAAVLDTSGRSGEEVTVTGYPADRKVPRTCTAVTVRESA
                     TEQRFDCADFPGGTSGSAWIARDGKIIGILTGGDTDDVSTSTVLGEYAASLYAKATAKR
                     "
     gene            complement(3117..3557)
                     /locus_tag="JIW86_RS23405"
                     /old_locus_tag="JIW86_23405"
     CDS             complement(3117..3557)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265757.1"
                     /locus_tag="JIW86_RS23405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23405"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_257555793.1"
                     /transl_table=11
                     /translation="MRTPRHAARVVILSPAGSVFLFREDNVEVGIHWLPPGGGIDPGES
                     PEECVRRELREETGWTDVEPGRLLCTWEHDFTHQGIPVRQHEHIYLTTGPHRDPVPEYP
                     GIHWQWLSPQHLATLGEPLWPPRLPDLLANAPAEPVHLGLVT"
     misc_feature    complement(3531..3544)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.52"
                     /tool="antismash"
     misc_feature    complement(3576..3591)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.32"
                     /tool="antismash"
     gene            complement(3597..4835)
                     /locus_tag="JIW86_RS23410"
                     /old_locus_tag="JIW86_23410"
     CDS             complement(3597..4835)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019764614.1"
                     /locus_tag="JIW86_RS23410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23410"
                     /product="ABC transporter permease"
                     /protein_id="WP_257555794.1"
                     /transl_table=11
                     /translation="MSRARTRTRTRTARRAGRLTPPRLSPRDVLHVGSAGLRSRPMRVF
                     LSALGIAIGIATMIAVVGISSSSQAKLLRELDRLGTNMLVATPGQGMFTGQDTKLPKDA
                     PGMISRIQGVESVGTTGDVGESVRRSENIPAEETGGIVLKAAKDDLLGTLRARTDSGTW
                     LNEATGRYPSVVLGDVSARRLGITEPGQQVFIGGRYFTVIGILAPVPLAPEIERSALIG
                     WDAAERLLGFDGHPTAVYERSADDRVAQVRNLIAPTATPQTPSAVAVTDPSAALQAKAA
                     TEGAFSTLLLGLGGIALLVGGVGVANTMIISVLERRHEIGLRRSLGATKGQIRIQFVTE
                     SLLLSGLGGLAGIALGAAATAVYARAGDLPWVVPLWAVTGGFAATLAIGTLAGLYPAVR
                     AARLSPTLALAAG"
     gene            complement(4835..5542)
                     /locus_tag="JIW86_RS23415"
                     /old_locus_tag="JIW86_23415"
     CDS             complement(4835..5542)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006350644.1"
                     /locus_tag="JIW86_RS23415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23415"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257555795.1"
                     /transl_table=11
                     /translation="MTHTHPVVELAGVTKEYPGGVAALRGVDLTVTSGELLAIVGPSGS
                     GKSTLLHIVGTLDRPTAGGVRIAGHDVAALSDRSLSALRSRHVGFVFQSFHLVPGVSAR
                     ANVAEGLLYSGLSRAERGRRAERALERVGLGDRMEHRPHELSGGQKQRVAIARAVAGTP
                     DLLLADEPTGALDTASGESVMALLHELNADGATIAVITHDHEIAASLPRQVRIRDGEIV
                     ADVRNATAGAGVA"
     gene            complement(5539..6639)
                     /locus_tag="JIW86_RS23420"
                     /old_locus_tag="JIW86_23420"
     CDS             complement(5539..6639)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126694.1"
                     /locus_tag="JIW86_RS23420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23420"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_257555796.1"
                     /transl_table=11
                     /translation="MSRRGRWLLGSLAVVLAASGGGYAVMAQPQQESRNEQRGDGLPPA
                     TAPVQRGDLSSGLQVEGTLGYAQERKVNAAGPGVLTWLAGEGTAVERDGRLYEVNGKAV
                     RLMYGSTPVYRPLKAGDKGEDVKQLKRNLQALGHGTGLDPEDATFTAGTATAVKRWQKA
                     HKMPETGEVAKEDIAFASGPQRVRKNDSAVGDEPGPGKPVMTLTGTERVVRFQMDAAKA
                     GAAKTGEPVTVRLPGGTTVTGKIESVGGTAAPDGKNEGGGPGGGSGGDKKAKVEVGVAL
                     DKPSEVNAPDQSPVSVGLTGEIRKGVLSVPVNSLLALAGGGFGVQVVEDGRAREVKVEP
                     GMFGNGRVEVTGDALKEGMQVGIPKL"
     gene            complement(6636..7163)
                     /locus_tag="JIW86_RS23425"
                     /old_locus_tag="JIW86_23425"
     CDS             complement(6636..7163)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS23425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_23425"
                     /product="hypothetical protein"
                     /protein_id="WP_257555797.1"
                     /transl_table=11
                     /translation="MKRSLIMTTAVAITGLTLAVTGCANGSGGSGGSGGSGGEKKDSAS
                     GGSGGGSGSGSGTDADNAVKMRQCLREHGIDAPDPKPGQDPRGMTVGGGVDPEKMQEAM
                     KACGMGGPGSGKEPTQEEKDKELKWIRCMRENGIQLKDPEYNGGARTGIEIPQGQEKAF
                     EDAQKKCEAARS"
     misc_feature    7234..7251
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            7254..7916
                     /locus_tag="JIW86_RS23430"
                     /old_locus_tag="JIW86_23430"
     CDS             7254..7916
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265761.1"
                     /locus_tag="JIW86_RS23430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23430"
                     /product="response regulator transcription factor"
                     /protein_id="WP_257559405.1"
                     /transl_table=11
                     /translation="MRVLVVEDEEFLREMIAEGLRRDALAVDEAADGLEALERLRLGAY
                     DVLVLDRDLPGLHGDEVCRQVVRERLLTRVLMLTASGTVRDRVEGLGLGADDYLTKPFA
                     YDELLARVLALGRRARPALPPVLERAGVAVDTARRSATRDGRRLALSRKEFAVLEALLR
                     AEGAVVSNDDLIEDVWEQDTSYSTNAVRVTLSKLRAKLGEPPLIETVPGAGYRIAAR"
     gene            7913..9154
                     /locus_tag="JIW86_RS23435"
                     /old_locus_tag="JIW86_23435"
     CDS             7913..9154
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265763.1"
                     /locus_tag="JIW86_RS23435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23435"
                     /product="ATP-binding protein"
                     /protein_id="WP_257555798.1"
                     /transl_table=11
                     /translation="MTGFPRGVLRTERGRLTALYGSLLLLAGGGLVALVYVLVGQGLYA
                     SVSGAVSTVSPALRAGEKLDLDPGRSPEAARSPGPGETPTPEEMRTYALTRNLSDAVTQ
                     AAQHRLLIVSLIALAVFAVLSIWLAWWMAGRVLRPVAVITGTARRLSGENLDERIALDA
                     PPGELKELADTFDAMLGRMEHLVSAQRRFAANAAHELRTPLAVQRAAAEIGLAGDPSPE
                     RVARIRERLIGVAESSEHLIESLLLLAVSEEGLESTGRVDLAALAAAELAACPQEGLTV
                     ERTLAPLAVTGDRTLLGHLVRNLLTNAVRHNRAGGRLTLATSAEGELTVSNTGPVIDPA
                     DVPRLLEPFRRSAERQHTAGEGAGLGLSIVASIARAHGAELTARANPAPDGGLTIRLRF
                     PVADARRQGSVQPE"
     gene            9181..10029
                     /locus_tag="JIW86_RS23440"
                     /old_locus_tag="JIW86_23440"
     CDS             9181..10029
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605054.1"
                     /locus_tag="JIW86_RS23440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23440"
                     /product="L,D-transpeptidase family protein"
                     /protein_id="WP_215146578.1"
                     /transl_table=11
                     /translation="MSKHRRARSRTLRTSRTPRPGSTRTSSPTSRRVALAATFGLLTFA
                     AGWVYALDDNAVGTASQARADSRPQAPDRAARDAQREAPRAPLQGLTGISEQTLARIPA
                     ESRQLVLVTGKAGDSSESTAALYTRPAAGADWVRTESWPARNGAKGWSTERTYGDLTSP
                     QGVFALTDAGGLLAPPPGTRLPYDKDRAFVATGRGVNGESLAGSFDYVVAIDFNRRPGK
                     SPLDPVKPEGEDKGGNIWLHVDHDGPSQGCVGIPKEAMKKVLATLDPAAKPVIVMGPEG
                     F"
     gene            complement(10001..10654)
                     /locus_tag="JIW86_RS23445"
                     /old_locus_tag="JIW86_23445"
     CDS             complement(10001..10654)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TS_Pyr4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265765.1"
                     /locus_tag="JIW86_RS23445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23445"
                     /product="hypothetical protein"
                     /protein_id="WP_257555799.1"
                     /sec_met_domain="TS_Pyr4 (E-value: 2.8e-23, bitscore: 81.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLILTLVSGIAWTVVYLEAIRVGLRDRTYAMPVAALALNFAWES
                     IYAVREFTDSGMTAQGVVNVVWAAADVVIVFTYLRFGRAELPRFVTRPMFAAWSVLVFA
                     TGFAVQGLFLAHFGAHDASRYSAFLQNLLMSGLFIGLFAARQGPRGQSLTIAVAKWLGT
                     LAPTVLFGVLADAPFILGLGILCSVFDLVYIGLLLQARRRTPAAPVRSLPDPSR"
     misc_feature    complement(10639..10653)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            10792..11748
                     /locus_tag="JIW86_RS23450"
                     /old_locus_tag="JIW86_23450"
     CDS             10792..11748
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641028.1"
                     /locus_tag="JIW86_RS23450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23450"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_257555801.1"
                     /transl_table=11
                     /translation="MARVFPEGRLVYGMQLPVQSQSTIYAEPWEASATAADLAEVARAA
                     DRAGFGYLATCDHVAIPRRLAGPMSTVWYDPVATLSFLAGITEHVRLLSHVAILGLRHP
                     LISAKQYATLDHLSGGRLILGVGAGHVQEEFEILGVDFARRGAVLDETLDALRAALGPE
                     EYPEFEGELFSFKDLGQLPRPAQERIPVWVGGSSPAAVRRAALRGDGWLPQGDPREKLP
                     AQIARIKELRAAAGVAGPVEFGAITEALYVGEPGWDTGRRTLTGKAEVLAESLREYKAL
                     GVDQIQVRFRNRDRAELVDQITAFGAEVAPLLNDWES"
     gene            11751..12536
                     /locus_tag="JIW86_RS23455"
                     /old_locus_tag="JIW86_23455"
     CDS             11751..12536
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-164). E-value: 1.9e-10. Score:
                     32.9. Matches aSDomain:
                     nrpspksdomains_JIW86_RS23455_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740713.1"
                     /locus_tag="JIW86_RS23455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23455"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_215146581.1"
                     /sec_met_domain="adh_short (E-value: 1.6e-30, bitscore:
                     105.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKLDGRVVIITGAARGQGEQEARLFAAEGARVLLGDVLDEQGAA
                     VAKEIGEDRARYVRLDVSREEDWAGAVAVAKEAFGPVDGLVNNAGILRFNELTATPLEE
                     FQQVVQVNQVGAFLGIKSVAPEIEAAGGGTIVNTSSYTGLTGMAYVGTYAATKAAILGL
                     TRVAALELAGKGIRVNAMCPGAVDTPMANPGLLDPAGMTDEAREAMADLYKRVVPMGRV
                     GQPEEIAKLALFLTSEDSSYITGQPFVIDGGWMAGVSIL"
     aSDomain        11772..12242
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS23455_PKS_KR.1"
                     /evalue="1.90E-10"
                     /label="JIW86_RS23455_PKS_KR.1"
                     /locus_tag="JIW86_RS23455"
                     /protein_end="164"
                     /protein_start="7"
                     /score="32.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVIITGAARGQGEQEARLFAAEGARVLLGDVLDEQGAAVAKEIGE
                     DRARYVRLDVSREEDWAGAVAVAKEAFGPVDGLVNNAGILRFNELTATPLEEFQQVVQV
                     NQVGAFLGIKSVAPEIEAAGGGTIVNTSSYTGLTGMAYVGTYAATKAAILGLT"
     misc_feature    complement(12615..12624)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            12642..13763
                     /locus_tag="JIW86_RS23460"
                     /old_locus_tag="JIW86_23460"
     CDS             12642..13763
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740712.1"
                     /locus_tag="JIW86_RS23460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23460"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_257555802.1"
                     /transl_table=11
                     /translation="MEFGLFVQGYVAESRSKVDPEAEHKALIEETEYVIQADKSGFKYA
                     WASEHHFLEEYSHLSANEVFLGYLAHATERIHLGSGIFNPLAPVNHPVKVAEKVAMLDH
                     LSKGRFEFGTGRGAGSHEILGFLPGIEDMNGTKEIWEETIAEFPKMFLQEEYEGFQGKH
                     WSLPPRKIFPKPYGKAHPAMWYAAGSPSSYAMAAKKGLGVLGFSVQKVSDMEWVLDQYK
                     TAIQEAKAIGAFVNDNVMVTSTAICAETHDKAIEIAVNANMNRFQSLVFRYHDTFPRPE
                     AIPQWPELLPEYNAEIIELLIAEELMICGDPSEVLQQCKRWEQAGADQLSFGLPTGVSY
                     EDTMTTIKLLGEHVIPEIDTDPVHRTTRFRQAV"
     gene            14038..15777
                     /locus_tag="JIW86_RS23465"
                     /old_locus_tag="JIW86_23465"
     CDS             14038..15777
                     /EC_number="3.5.1.-"
                     /GO_function="GO:0047420 - N-acyl-D-amino-acid deacylase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552179.1"
                     /locus_tag="JIW86_RS23465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23465"
                     /product="D-aminoacylase"
                     /protein_id="WP_257555803.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.5e-07, bitscore:
                     29.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDHLIKGATVVDGTGAPARPADVGIRDGRIVAIAPPGTVEEDAR
                     TTEDATGLVLTPGFIDPHTHYDAQLFWDPYATPSMNHGVTTVAGGNCGFTLAPLHPDRP
                     EDADYTRRMMSKVEGMALKALEDGVDWTWSTFGEYLDALEGRIAVNAGFMVGHCALRRH
                     VMGEDAVGGQPTPEQLQQMLDLFHDAMNAGAWGLSTTQSSTHSDGAGAPVASRHAKPAE
                     LLALSKAVAEHEGTQLEAIVAGCLDQFSDEEIDLFVEMSAAAGRPLNWNVLTIDASVPE
                     RVPRQLIPSERAREAGGRIVALTMPILTPMNMSLGTFCALNLIPGWGEVLALPVAERIE
                     KLRDPAVRAEMLKRADSKEAGVFRRLANFGRYVIGDTYSKENEGLSGRVVNDIAAERGQ
                     DAFQCLVEICANDELRTVLWPMPTDNDPASWALRAETWQHEDVMLGGSDAGAHLDRMCG
                     APYTTRFLGDCLRGRKLVPLEQAVRMLTDDPAQLFGLRERGRIAEGFHADLVLFDPERI
                     EAGPATLVHDLPGDSPRLDARAVGIVSVRVNGVETIRDDEVTGAIPGIVLRSGRDTRTV
                     STR"
     misc_feature    complement(14042..14057)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            15774..17231
                     /locus_tag="JIW86_RS23470"
                     /old_locus_tag="JIW86_23470"
     CDS             15774..17231
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265772.1"
                     /locus_tag="JIW86_RS23470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23470"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_257555805.1"
                     /sec_met_domain="Aldedh (E-value: 1.4e-157, bitscore:
                     523.8, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKLFIGGEWVEPEGGHYEVVNPADESVVGLAPEASPAQVAEAAR
                     AAAEAFGAWSRTRPEERAAILDRAADIIQREYEPWTALAQAETGAPTGIARGMQVGVGV
                     ARFRRYARGALEPVEKGLPPQVTEAGPMGKAGVLGALEVRQPVGVVTCITSYNNPWANP
                     AGKVAPALAMGNTVVVKPAPQDPLSVFKMAEALAEAGVPPGVVNVVNGQSVAVGEAAVD
                     SPDVDMVSFTGSTAVGQRIAEVCGRTMKRQLMELGGKGAAIVFEDADLDAAMMGIGTTF
                     SFYSGQICTAPTRVIVHRSVHDALVEKLTGYLAFMKVGEPAAQGTVVGPVISAAHRDRV
                     ESYIELGKKEGARIAVGGDRPAVRADGKGFYVAPTLLVDCTNDMRVVREEVFGPVVVVV
                     PFDTEEEAVALANDSDFGLISYVWSGDPSRAFGVARRLRSGGVGVNTIGRNMEAPFGGF
                     KRSGVGRDVGSYALHAYSEIQSIVWTT"
     gene            complement(17240..18091)
                     /locus_tag="JIW86_RS23475"
                     /old_locus_tag="JIW86_23475"
     CDS             complement(17240..18091)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055057.1"
                     /locus_tag="JIW86_RS23475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23475"
                     /product="RNA polymerase sigma-70 factor"
                     /protein_id="WP_257555806.1"
                     /transl_table=11
                     /translation="MIEIADFEQHRPMLFGIAYRMLGSVADAEDLVQDTWLRCSQVPGP
                     VDNPRGYLARTITNLALNRLSSAAVKREQYVGPWLPEPLVTVPDATGDMELAESVSLAM
                     LVVLESLSPLERAVFVLKEVFGFSYREIAETLDRTETSVRQVGSRAKSHVQARRPRYAA
                     PAEVRRQVTDEFLAACLGGDLNRMLELLAPDVTAWNDGGGKVRAALRPLHGAENVARFL
                     AAVLAQPMEAPQLVAVDVNGLPGLLLTTAGRPDTVACVEVENGRITEIRVIRNPDKLRH
                     LA"
     gene            complement(18088..18648)
                     /locus_tag="JIW86_RS23480"
                     /old_locus_tag="JIW86_23480"
     CDS             complement(18088..18648)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055058.1"
                     /locus_tag="JIW86_RS23480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23480"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_257555807.1"
                     /transl_table=11
                     /translation="MTARISLAPPRTLLNRMGSWYSRRKYGEVLDPGLAIGHNQKVLLS
                     YVKLERSVAKWNALEPALRHLAVMATAARINCSWCMDFGHWEGSELGLPLDKISLVPQW
                     RHHREAFTELELQVMEYAEAMTETEPGVTDGLAEALLRRLGEAAFVELTAMVALENWRS
                     RMNSAFGLTSQGFSEACTVPSRT"
     gene            complement(18728..20482)
                     /locus_tag="JIW86_RS23485"
                     /old_locus_tag="JIW86_23485"
     CDS             complement(18728..20482)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037500.1"
                     /locus_tag="JIW86_RS23485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_23485"
                     /product="hypothetical protein"
                     /protein_id="WP_257555808.1"
                     /transl_table=11
                     /translation="MSARDERTALTAGTSLYDYALFRQGIDPDGPFPRRGHPLPDGPPE
                     PSRRSGLTWAQAGDEVAAALAPLLADADPVRAAEAVHLRADALRMPYRTLRAHVGRLPL
                     TDEAAARRTARRLTRTGTSTAAVSVGLALLIRLGEPEDVPCLKVLGLLRGLGQAAAAAL
                     DPLDRQAAALLLLAHRSRAPEMAPLLAAFSTRDAQDARTALVALPPDAEVLWLARRIAE
                     AADLEGLLRAYPQDGELLDRAGRLLYRMASQRDYRAEILDYGPAVAVYEALVGHADRLS
                     PTLDHHVLLLVLALDLHTGPGVLLDWRPGQREALLDALDRLLAGPAWTAVSVREQQDAD
                     ARRRADWIRRTRRQPFVRLPAPKRFRLEVVVRDPAEANAVETRILVDGRPLVTEHFGKG
                     PAGSPELLLDTGELRAGAEPREVQLAEAYCTEGCCGALYVTIRRDGDEVVWGDWRGAVG
                     PTPPEYRFAAAAYDAEVGRAERDRSWCWPARNTARLIKAGLRERPDLLTRWDVEPGWVG
                     TSWREPDTVDVGFSIRPEAETEAESEGGSRRYFHWTLRDDGRPPEAQAAAALDRLATAD
                     PKTFADGR"
ORIGIN
        1 tgccgtatga gcagcaacgc caactgccag gccagcaccg cgtgcacgag caggcaggtg
       61 ccccaggcgc gcccgcgcga tccgtggcgc gccaccgcga cccatccggc cgccaccagc
      121 acggcggcca ggatccacag ggcccagcag gcgatgagcc acgcgccggt gggctccgcg
      181 aagagccgga tgaccgcggg cggcgcgagc accaggaggg gaacgcccca cgtgccctcg
      241 gtggcggtgc gaggagaacg cgtatcggac atcggtgaaa cctccgtgtc gccttacctg
      301 aaaatcccac tctgtcatcc gcaacggtcg ggcggacggc gggtgttcgt gagcgatccg
      361 gtcagtgggg gtgacgcttc cggtcatgcc cttcgggcgc cgcggctgcc tagcgtcggg
      421 ggtcaccaac tcccggggag ggcatgcgat ggacgtcgac ggccggccga gcacgctggc
      481 gcagttcacc cagtggaccg aggagcggta cgggccggag atcgccctcc ggttccgggc
      541 gccgggagac ggcggctggc agacccgcac gtacggggaa ctgggcgcgg aggtacgggc
      601 cgtcgggcgg gcgctgctcg ggatgggggt ggccgcgggc gagcgggtgg ccgtactggc
      661 ggagacccgg ccgcagtgga cgtacaccca cttcggggtg ctggcggcgg gcgcggtcct
      721 cgtccccgtg tatccgacgg cgggggagga ggagctcgcc tgggtgctgg cggactccga
      781 ggcggtggtc gtggtctgcg acgacgcggc gcaggcgcaa cgggtcgagg cgctgcgggc
      841 cgaacttccc gcgctgcggg cggtggtggg gatggacgca ctgccgtccc tgccgcaggc
      901 cccggaggcc gaactcctcg cgcgcgcggc ggccgtcgcg cccggggcgg acgcgtcgat
      961 cgtctacacc tcgggcacca cgggcctgcc gaagggctgc cgcctcaccc acgggaacct
     1021 cggcgcgatc caggacgcca ccctcccgct gatcaggggc ggcccggggg actcgacgta
     1081 cctctacctg ccgctcgcgc acctgctggc acagctgatc cagttctcga cgctgctgga
     1141 gggcggggag ctctgctact tcggcggcag gatcgaggac gtgctggcgg agctggcggt
     1201 ggtccgcccg acccatctcc cttccgtgcc ccggctgttc gagaagctcc actcggtggt
     1261 gctgtccctg gcggaggccc gggagggcgg ccgggaacgc ctcgaggagg cggtacggct
     1321 gggcgtgctg gcggcggagg gccggctgcc ggaatcccgg cgggaggagt acgaggcggc
     1381 cgagaaatcg ctgtactccc tggtccgggg cgcgttcggg ggccgcctga agtgggcgct
     1441 caccggcggc gccccgatcg ccccggcgac cctggacctg ctgcgggcct gcgggatcgc
     1501 ggtgtacgag gggtacggga tgacggagtc gggcggtgtc atctccctca accacccgga
     1561 cgcggtgcgg tacgggacgg tggggcgccc gatcgcgggc tgcgaggtgc ggatcgcgga
     1621 ggacggggag gtgctggcgc ggggggcgat ggtgttcccg ggctaccacg cgaacgagaa
     1681 ggcgacggcg gaggcgctgg acccggaggg ctggctgcac accggcgacc tgggcgaact
     1741 ggacgccgag gggtacctgc ggatcaccgg ccggaagaag gagatcgtca tcacctcggc
     1801 ggggaagaac ctcaccccga cggaggtcga gttcgccatc cagcgctcgc gctacgtctc
     1861 ccgcgcggtg atgatcggcg accgccggcc gcacccggtg gccctgatca ccctggacgc
     1921 ggaggagatc ggggcctggg cggcccgcga gggccacgac ctgggcgccg ccccatccac
     1981 ccacccggcg gtccgcgccc tgatcgaggc ggccgtgacg gaggccaacg ccacggtctc
     2041 ccgcccggcc cgcatccggg ccttccacgt cctccccgag gacttcacga tcgcctcggg
     2101 gaccctgacc ccgacgctga agctccggcg gagggcggtg gcggagcggt acgcggggga
     2161 gatcgagggc ttgtacgggg ggtgaggcct tgcacccggc cctgcccgcg gggcatgctt
     2221 cgccggggca aagcggaagg atcatcatgc cggtggacaa gcggaccgtc gtgaccgtgg
     2281 tgttgtgtgc cgcggcggca ttgggggctt ccgccgccgt ggccgagctg gtgccaccgc
     2341 ccgagggggt cgcgcccgtg cgggcgaagg ccgcgccgac ggggtcggcg acggctccgt
     2401 cgcgttcgca agcagcgaag ccgcagctct cgaccccgcc caagagcacc ctgccgcccg
     2461 ccgtcacccc tcagcccggc gggcccgcgg ccttcaccgg ggccctgttc acggacggcc
     2521 tggacagcga ccacttctgc accgcgaccg tggtgcagag ccccggccgg aacctgatcg
     2581 tcaccgccgg gcactgcctg ctcgacgggg accagggcgg cggcaccgcc gtcttcgcac
     2641 ctgcatacgc caacggggtc gccccgtacg gcacatggaa gctcgaggaa gccttcgagg
     2701 acgaccgctg ggccgagggc acggacgaca gctacgacct cgccttcgcc cgcctggccc
     2761 ccgacgccac gggccggtcc atcgaggacg tgaccggtgc ggccgtgctg gacaccagcg
     2821 gccgctcggg tgaggaggtc accgtcaccg gttaccccgc cgaccgcaag gttccccgta
     2881 cctgcacggc ggtcaccgtc cgcgagagcg cgaccgaaca gcgcttcgac tgcgccgatt
     2941 tccccggcgg caccagcggc agcgcgtgga tcgcccggga cggcaagatc atcggcatcc
     3001 tgacgggcgg cgacaccgac gacgtgtcga ccagcaccgt cctcggcgag tacgccgcct
     3061 cgctgtacgc caaggccacc gccaagcgct gagcggtcac cgcgtcctgg actgggctag
     3121 gtgaccagtc ccaagtggac cggctcggca ggggcgttcg ccaggaggtc cggcaggcgc
     3181 ggcggccaca gcggttcgcc gagggtggcc aggtgctgcg gggagagcca ctgccagtgg
     3241 atgccgggat actccggcac cggatcgcgg tgcgggcccg tcgtgaggta gatgtgctcg
     3301 tgctggcgga ccgggatccc ctggtgcgtg aagtcgtgct cccaggtgca cagcagccgc
     3361 ccgggctcca cgtcggtcca gccggtctcc tcgcgcagct cgcgccgtac gcactcctcg
     3421 gggctctcgc cggggtcgat ccccccgccg ggcggcagcc agtggatgcc gacctccacg
     3481 ttgtcctcgc ggaagaggaa caccgacccg gcgggggaca ggatgacaac gcgcgctgcg
     3541 tgacgtggag ttctcatcga atcagcctac gccggtgatc cctcccggcg tccgggttat
     3601 cccgccgcca gcgccagcgt gggggacagc cgggccgccc ggaccgccgg gtagaggccg
     3661 gccagggtgc cgatcgccag ggtggccgcg aagcctccgg tcaccgccca gagggggacc
     3721 acccaaggga ggtcgcccgc ccgggcgtag acggccgtgg ccgccgcgcc cagggcgatg
     3781 cccgccaggc ctccgagccc ggacagcagc agggactccg tcacgaactg gatccggatc
     3841 tgccccttcg tggcccccag cgagcggcgc aggccgatct cgtggcggcg ttccagcacc
     3901 gagatgatca tggtgttggc gacgccgacc ccgcccacca gcagtgcgat cccgcccagc
     3961 cccagcagca gggtgctgaa ggcgccctcc gtggccgcct tcgcctggag ggccgccgag
     4021 gggtcggtga ccgcgaccgc gctcggcgtc tggggggtgg ccgtcggggc gatcaggttc
     4081 cgcacctgcg ccacccggtc gtccgccgac cgttcgtaca ccgccgtcgg gtgcccgtcg
     4141 aagcccagca gccgctctgc cgcgtcccag ccgatcagcg ccgagcgctc gatctccgga
     4201 gccagcggaa ccggcgccag gatgccgatc accgtgaagt accggccgcc gatgaacacc
     4261 tgctggcccg gctcggtgat gcccaggcgc cgcgccgaga cgtcgccgag caccaccgac
     4321 ggatagcggc cggtggcctc gttgagccag gtgccgctgt ccgtccgggc gcgcagcgtg
     4381 cccagcagat cgtccttggc cgccttcagc acgatcccgc ccgtctcctc cgcggggatg
     4441 ttctccgagc ggcgtacgga ctcgcccaca tcgccggtgg tgccgaccga ctcgaccccc
     4501 tggatgcggg agatcatgcc cggggcgtcc ttgggcagtt tggtgtcctg cccggtgaac
     4561 atcccctgcc cgggcgtcgc gaccagcatg ttcgtaccga gccggtccag ctcgcgcagc
     4621 agcttggcct ggctggagga ggagatcccg accaccgcga tcatcgtcgc gatgccgatg
     4681 gcgatgccga gcgcggacag gaacacccgc atcgggcgcg agcgcaaacc ggccgaaccg
     4741 acgtgcagga cgtcgcgggg ggacagcctc ggcggggtca gccgcccggc acgacgggcc
     4801 gtacgggttc gggtacgggt gcgcgcacgg ctcatcacgc cacccccgcc ccggccgtcg
     4861 cgttccgtac gtccgccacg atctcgccgt cccggatccg cacctgccgc ggcaggctgg
     4921 cggcgatctc gtggtcgtgg gtgatcacgg cgatggtggc cccgtccgcg ttcagctcgt
     4981 gcagcagcgc catcaccgac tccccggacg ccgtgtccag cgcgcccgtc ggctcgtcgg
     5041 ccagcagcag gtccggggtg cccgccacgg cgcgggcgat cgccacccgc tgcttctgcc
     5101 cgccggacag ctcgtgcggc cggtgttcca tccggtcgcc gaggccgacc cgctccaggg
     5161 cccgctccgc ccggcggccg cgctcggccc gcgagaggcc ggagtagagc aggccctcgg
     5221 cgacgttcgc ccgggcgctg acgcccggca ccaggtggaa ggactggaag acgaagccga
     5281 cgtgccggga gcgcagcgcc gacagcgagc ggtccgagag ggccgcgacg tcgtgaccgg
     5341 cgatccgcac gccgcccgcc gtcggccggt ccagggtgcc gacgatgtgc agcagggtgg
     5401 acttcccgga tccggacggg ccgacgatgg ccagcagttc gccgctcgtg acggtcaggt
     5461 cgaccccgcg cagggccgcg accccgcccg ggtactcctt ggtgaccccg gccagttcga
     5521 ccacgggatg cgtgtgcgtc atagcttcgg gatccccacc tgcatgccct ccttgagggc
     5581 gtcgccggtc acctcgaccc ggccgttgcc gaacatgccc ggctccacct tgacctcgcg
     5641 cgccctgccg tcctcgacga cctggacgcc gaagcccccg ccggccagcg ccagcagcga
     5701 gttgaccggt acggagagca cgcccttgcg gatctcgccg gtcaggccga ccgacaccgg
     5761 ggactggtcg ggggcgttga cctcggaggg tttgtccagc gcgacgccca cctcgacctt
     5821 ggccttcttg tcgccgccgg agccgccgcc ggggccgccg ccttcgttct tcccgtccgg
     5881 agcggccgtg ccccccaccg attcgatctt cccggtgacg gtggttcctc ccggcagccg
     5941 cacggtgacc ggctcgccgg tcttcgccgc gcccgccttc gccgcgtcca tctggaagcg
     6001 gacgacccgc tcggtgccgg tcagcgtcat cacgggcttg cccggccccg gctcgtcacc
     6061 gacggccgag tcgttcttcc gcacccgctg cggccccgag gcgaaggcga tgtcctcctt
     6121 ggcgacctcg cccgtctccg gcatcttgtg cgccttctgc caccgcttga cggccgtcgc
     6181 cgtacccgcc gtgaacgtgg cgtcctcggg gtccagcccc gtcccgtggc ccagcgcctg
     6241 gaggttgcgc ttgagctgct tgacgtcctc gcccttgtcc ccggccttca gcggccggta
     6301 cacgggcgtg gacccgtaca tcaggcgcac cgccttgccg ttgacctcgt acagcctccc
     6361 gtcccgctcg accgccgtgc cctcgcccgc gagccaggtc aggacgcccg gcccggccgc
     6421 gttgaccttg cgctcctgcg cgtagccgag ggtgccctcc acctggaggc ccgagctgag
     6481 gtcgccgcgc tgcacgggcg cggtggccgg cggcaggccg tcgccgcgct gttcgttcct
     6541 gctctcctgc tgcggctggg ccatgaccgc gtacccgccg cccgaggcgg cgagcacgac
     6601 ggccagcgaa cccagcagcc acctgccgcg cctgctcacg agcgggccgc ttcgcacttc
     6661 ttctgggcgt cctcgaaggc cttctcctgg ccctggggta tctcgatgcc ggtccgcgcg
     6721 ccgccgttgt actcagggtc cttgagctgg atcccgttct cgcgcatgca gcggatccac
     6781 ttgagctcct tgtccttctc ctcctgggtg ggctccttgc ccgagcccgg gccgcccatc
     6841 ccgcaggcct tcatggcctc ctgcatcttc tccgggtcga cgccgccgcc gaccgtcatc
     6901 ccgcgcgggt cctggccggg cttggggtcg ggcgcgtcta tgccgtgctc gcgcaggcac
     6961 tggcgcatct tcacggcgtt gtccgcgtcc gtacccgatc cggagcccga gccgccgccg
     7021 gagccgccgg acgcggagtc cttcttctcg ccgcccgagc cgcccgagcc gcccgagccg
     7081 cccgagccgt tcgcgcaccc ggtgacggcg agggtgaggc cggtgatggc cacggccgtg
     7141 gtcatgatga gggatcgctt catgggcccg accctgcggc aaagggccct ttcgcttccc
     7201 tctcccaccg tgcttacaac gccgaaatgc cgatctccgg tagagaggac ggcatgcgcg
     7261 tactggtggt ggaggacgag gaattcctcc gggagatgat cgccgagggg ctgcgccgcg
     7321 acgcgctggc cgtcgacgag gccgccgacg gcctcgaggc cctggagcgc ctgcgcctgg
     7381 gcgcgtacga cgtcctggtc ctggaccgcg acctgcccgg tctgcacggt gacgaggtct
     7441 gccgccaggt ggtgcgcgag cggctgctga cccgcgtcct gatgctgacc gcgtccggga
     7501 ccgtacggga ccgcgtcgag ggcctgggcc tgggcgccga cgactacctc accaagccgt
     7561 tcgcctacga cgagctcctg gcccgcgtcc tcgcgctggg ccgccgcgcc cgccccgcgc
     7621 tgccgcccgt actcgagcgc gccggggtcg ccgtcgacac cgcccgccgc agcgccaccc
     7681 gcgacggacg ccggctcgcc ctgtcccgca aggagttcgc cgtcctggag gcgctgctgc
     7741 gcgccgaggg cgcggtggtc agcaacgacg acctcatcga ggacgtctgg gagcaggaca
     7801 ccagctactc caccaacgcc gtccgcgtca cgctcagcaa gctccgcgcc aagctgggcg
     7861 agccgccgct catcgagacc gtgcccggtg cgggctaccg gatcgccgcc cgatgaccgg
     7921 gttcccgcgg ggcgtcctgc gcaccgagcg cggccggctc accgccctgt acgggtccct
     7981 gctgctcctg gcgggcggcg gactggtggc gctggtgtac gtcctggtcg gccaggggct
     8041 gtacgcgagc gtcagcgggg ccgtcagcac cgtcagcccc gcgctgcgcg cgggcgagaa
     8101 gctggacctg gacccaggcc gcagccccga ggccgcccgg agcccgggcc cgggcgagac
     8161 gcccaccccg gaggagatga ggacgtacgc cctcacccgc aacctgtcgg acgccgtcac
     8221 ccaggccgcc cagcaccggc tgctgatcgt ctcgctcatc gccctcgccg tcttcgccgt
     8281 cctgtcgatc tggctggcct ggtggatggc cgggcgggtg ctgcgccccg tcgccgtgat
     8341 caccgggacc gcgcggcggc tgtccggcga gaacctggac gagcggatcg ccctggacgc
     8401 cccgcccggc gagctcaagg agctcgccga caccttcgac gcgatgctgg ggcggatgga
     8461 gcatctggtc tccgcccagc ggcggttcgc ggcgaacgcg gcgcacgagc tgcgcacccc
     8521 gctcgccgtg cagcgggcgg cggccgagat cgggctggcc ggggacccgt cgccggagcg
     8581 ggtcgcccgg atccgcgagc ggctcatcgg cgtcgcggaa tccagcgagc acctcatcga
     8641 gtcgctgctg ctgctcgcgg tgtcggagga ggggctggag tccaccgggc gggtggatct
     8701 tgcggcgctg gccgccgccg aactggcggc ctgcccgcag gagggcctga cggtggaacg
     8761 caccctggcc ccactggccg tgacgggcga ccggacgctc ctgggccacc tggtccggaa
     8821 cctgctgacc aatgccgtac gtcacaaccg cgcgggcggg cggctcaccc tggccacctc
     8881 cgccgagggg gaactgacgg tgtccaacac cggccccgtg atcgatccgg ccgatgtgcc
     8941 gaggctcctg gagccgttcc ggcggagcgc ggaacggcag cacaccgctg gtgagggcgc
     9001 cggtctggga ctttcgatcg tcgcctcaat cgcgcgggcg cacggggcgg agctgacggc
     9061 gcgggccaat ccggcgccgg acggcgggct gacgatccgg ctccgcttcc cggtggcaga
     9121 cgcccggcgg cagggcagcg ttcagccgga gtgaagggcg gctgatgtac ggtcggttca
     9181 atgagcaagc accgccgagc ccgctcccgc acgctccgta cgtcgcgtac gcctcgtccg
     9241 ggaagtactc gtacgtcctc gcccacgtcc cggcgcgtgg ccctcgccgc gaccttcggc
     9301 ctgctgacct tcgcggccgg ctgggtgtac gcccttgacg acaacgccgt cggcaccgcc
     9361 tcgcaggcac gcgccgactc ccgtccccag gccccggacc gcgccgcgcg cgacgcccag
     9421 cgggaagctc cccgggcccc gctgcagggg ctgaccggca tcagcgagca gaccctggcg
     9481 aggatcccgg ccgagtcccg ccagctcgtc ctggtcaccg gcaaggccgg ggactcctcg
     9541 gagtccaccg ccgcgctcta cacccgtccc gcggccggcg ccgactgggt gcggaccgag
     9601 agctggccgg cccgcaacgg tgcgaagggc tggtccacgg agcgcacgta cggggacctg
     9661 acctccccgc agggcgtctt cgcgctcacc gacgcgggcg ggctgctggc gccgccgccc
     9721 ggcacccggc ttccgtacga caaggaccgg gcgttcgtcg ccacggggcg cggggtcaac
     9781 ggcgagtccc tggcggggtc cttcgactac gtcgtcgcca tcgacttcaa ccgcaggccg
     9841 gggaaatcgc ccctcgaccc ggtcaagccg gagggtgagg acaagggcgg caacatctgg
     9901 ctccacgtgg accacgacgg cccctcacag ggctgcgtcg gcattccgaa ggaggcgatg
     9961 aagaaggtcc tggcgaccct cgacccggcg gcgaagccgg tcatcgtgat gggtccggaa
    10021 ggcttctgac cggggcggcg ggagtccgtc ggcgggcctg gagcagcagc ccgatgtaca
    10081 ccaggtcgaa gacgctgcac aggatcccga gcccgaggat gaacggcgcg tccgcgagga
    10141 ccccgaacag cacggtcggg gccagcgtgc ccagccactt ggcgacggcg atggtcaggg
    10201 actgcccgcg cggcccctgc cgggctgcga agaggccgat gaacaggccg gacatcagca
    10261 ggttctgcag gaacgccgag tagcgcgagg cgtcgtgcgc cccgaagtgg gcgaggaaca
    10321 gcccctgcac ggcgaacccg gtggcgaaca ccaggaccga ccaggcggcg aacatcggac
    10381 gggtgacgaa ccgcggcagc tcggcccgcc cgaaccgcag ataggtgaag acgatcacca
    10441 cgtcggccgc cgcccacacc acgttcacca cgccctgggc ggtcatcccg gagtccgtga
    10501 actcgcggac cgcgtagatc gactcccagg cgaagttcag cgcgagcgcg gcgacgggca
    10561 tcgcgtacgt ccggtcgcgc agcccgacgc ggatcgcctc caggtacacg acggtccagg
    10621 cgatcccgct gaccagcgtg agtatgagat ccatccgcgc accctaggcg gtgtcccggc
    10681 cggggcacag cgccgggtcc tgtccgcccc cttgcctgac ggtccgtcag ctacgacgat
    10741 ggcccggcac cgatatgacg aatcggcaga cgaaggcgag gcgggtccgg catggcgcgc
    10801 gtgtttccgg agggtcggct ggtctacggg atgcagctcc cggtccagtc gcagagcacc
    10861 atctacgccg agccctggga ggcgtcggcc accgccgccg acctcgccga ggtggcgcgg
    10921 gccgccgacc gggccggctt cgggtacctg gccacctgcg accacgtggc catcccgcgg
    10981 cggctcgccg gacccatgag caccgtctgg tacgacccgg tggccaccct gtccttcctc
    11041 gccggcatca ccgagcacgt gcggctgctc agccacgtcg cgatcctcgg cctgcgccac
    11101 ccgctgatca gcgccaagca gtacgccacc ctcgaccacc tctcgggcgg ccggctgatc
    11161 ctcggcgtcg gcgccgggca cgtccaggag gagttcgaga tcctcggggt ggacttcgcc
    11221 cgccgcgggg ccgtcctcga cgagaccctc gacgcgctgc gggcggcgct cggccccgag
    11281 gagtacccgg agttcgaggg cgagctgttc tccttcaagg atctcggcca gctgccccgg
    11341 cccgcccagg agcggatccc cgtatgggtc ggcggctcct cgcccgccgc cgtccgccgg
    11401 gccgcgctgc gcggggacgg ctggctcccg cagggcgacc cgcgcgagaa gctcccggcg
    11461 cagatcgccc gcatcaagga gctgcgcgcc gcggccgggg tggccggccc cgtcgagttc
    11521 ggcgcgatca ccgaggccct gtacgtcggc gagcccggct gggacaccgg ccgccgcacc
    11581 ctcaccggca aggcggaggt gctcgccgag tccctgcggg agtacaaggc gctcggcgtg
    11641 gaccagatcc aggtccgctt ccgcaatcgc gaccgcgccg agctcgtgga ccagatcacc
    11701 gctttcgggg ccgaggtggc ccccctcctc aacgactggg agtcgtgacc atgggcaagc
    11761 tggacgggcg cgtcgtcatc atcaccggcg cggcacgggg ccagggcgag caggaggccc
    11821 gcctcttcgc cgccgagggc gccagggtgc tcctgggcga cgtactggac gagcagggcg
    11881 ccgcggtggc caaggagatc ggcgaggacc gggcccgcta cgtgcggctg gacgtgagcc
    11941 gagaggagga ctgggcgggc gcggtcgccg tcgcgaagga ggccttcggc ccggtcgacg
    12001 gcctggtcaa caacgcgggc atcctgcgct tcaacgagct gaccgcgacc ccgctggagg
    12061 agttccagca ggtggtccag gtcaaccagg tgggcgcctt cctcgggatc aagtcggtgg
    12121 cccccgagat cgaggcggcc ggcggcggca cgatcgtcaa cacctcctcg tacaccggcc
    12181 tgacgggcat ggcgtacgtc ggcacgtacg ccgccaccaa ggcggccatc ctcggcctga
    12241 cccgggtggc cgcgctggag ctggcgggca aggggatccg ggtcaacgcg atgtgcccgg
    12301 gcgccgtgga caccccgatg gccaacccgg gcctgctgga tccggcgggg atgacggacg
    12361 aggcgcggga ggcgatggcg gatctgtaca agcgggtcgt gccgatgggc cgggtcgggc
    12421 agccggagga gatagcgaag ctggccctct tcctgaccag cgaggactcc tcgtacatca
    12481 ccggccagcc gttcgtcatc gacggcggct ggatggccgg tgtgagcatc ctctagtcgt
    12541 atctgatgga gcgtcaggta ttgacgctcc cgccccagcg gtggaacagt cgagacatcg
    12601 aatctgacgc aacgtcagaa atcaaaggac ggtgaacccc cttggaattc gggctctttg
    12661 tgcagggata cgtggccgag tcacggtcca aggtcgaccc cgaggcagag cacaaggcgc
    12721 tgatcgagga gaccgagtac gtcatccagg cagacaagtc gggcttcaag tacgcctggg
    12781 cctccgagca ccacttcctg gaggagtact cgcacctgtc ggcgaacgag gtcttcctcg
    12841 ggtacctcgc gcacgccacc gagcggatcc acctcggctc cggcatcttc aacccgctcg
    12901 ccccggtgaa ccacccggtc aaggtggccg agaaggtcgc catgctcgac cacctctcca
    12961 agggccgctt cgagttcggc accggccgcg gcgcgggaag ccacgagatc ctcggcttcc
    13021 tgcccggcat cgaggacatg aacggcacga aggagatctg ggaggagacc atcgcggagt
    13081 tccccaagat gttcctccag gaggagtacg aggggttcca gggcaagcac tggtcgctgc
    13141 ccccgcggaa gatcttcccc aagccgtacg gcaaggcgca cccggccatg tggtacgccg
    13201 ccggctcccc ctcctcgtac gccatggcgg cgaagaaggg cctgggcgta ctgggcttca
    13261 gcgtgcagaa ggtctccgac atggagtggg tcctcgacca gtacaagacg gccatccagg
    13321 aggcgaaggc catcggcgcc ttcgtcaacg acaacgtcat ggtcacctcg accgcgatct
    13381 gcgccgagac ccacgacaag gcgatcgaga tcgccgtcaa cgccaacatg aaccgcttcc
    13441 agtcgctggt gttccgctac cacgacacgt tcccgcggcc ggaggccatc ccgcagtggc
    13501 ccgagctgct gccggagtac aacgcggaga tcatcgagct gctgatcgcc gaggaactga
    13561 tgatctgcgg cgacccgtcg gaggtcctcc agcagtgcaa gcgctgggag caggccggcg
    13621 ccgaccagct ctccttcggc ctgccgaccg gggtgtcgta cgaggacacg atgaccacga
    13681 tcaagctcct cggcgagcac gtgatccccg agatcgacac ggacccggtc caccgcacga
    13741 cgcgcttccg ccaggccgtc tgacccggcg gggggtcggg gcggcgtctt cccggaccgc
    13801 cgtcccgcag gccccggccg ggcggcctcc ggccggggcc cctgggctcc gcttacaggt
    13861 gcggcgccgc tgcgggggct ccgcccccgg acccccgcgc ctcaaacgcc ggcggggctg
    13921 ggttgtgccc ggcggacggc atcagccaga tccagccccg ccagcgtttg aggcgcgggg
    13981 tctggggcgg agccccagca cacggcccgc aacccgaaca ccggcagaag ggacgtcatg
    14041 ctcgaccacc tgatcaaggg cgccaccgtc gtggacggca ccggcgcccc cgcccgcccc
    14101 gcagacgtcg gcatacgcga cggccggatc gtcgccatcg caccccccgg cacggtcgaa
    14161 gaagacgcgc ggaccaccga ggacgccacc ggcctcgtcc tgacccccgg cttcatcgac
    14221 ccccacacgc actacgacgc ccagctcttc tgggacccgt acgccacccc ctccatgaac
    14281 cacggcgtca ccaccgtcgc cggcggcaac tgcggcttca ccctggcccc gctccacccg
    14341 gaccgccccg aggacgccga ctacacccgc cgcatgatga gcaaggtcga gggcatggcc
    14401 ctcaaggccc tggaggacgg cgtcgactgg acctggtcca cgttcggcga gtacctcgac
    14461 gccctcgagg gccggatcgc cgtcaacgcc ggcttcatgg tcggccactg cgccctgcgc
    14521 cgccacgtga tgggcgagga cgccgtcggc ggccagccca cccccgagca gctccagcag
    14581 atgctcgacc tcttccacga cgccatgaac gccggcgcct gggggctgtc caccacgcag
    14641 tcctccaccc actccgacgg ggccggcgcc cccgtcgcct cccggcacgc caagcccgcc
    14701 gaactcctcg ccctctccaa ggccgtcgcc gaacacgagg gcacccagct cgaagccatc
    14761 gtcgcgggct gcctcgacca gttctccgat gaggagatcg acctcttcgt agagatgagc
    14821 gccgccgccg gacggcccct gaactggaac gtcctcacca tcgacgcctc cgtcccggag
    14881 cgcgtcccgc gccagctgat cccgagcgag cgcgcccgcg aggccggcgg ccgcatcgtc
    14941 gcgctgacga tgccgatcct cacccccatg aacatgtcgc tcggcacctt ctgcgcgctc
    15001 aacctcatcc ccggctgggg cgaggtcctc gccctgcccg tcgccgagcg gatcgagaag
    15061 ctgcgcgatc cggccgtacg cgccgagatg ctgaagcggg ccgactccaa ggaggccggg
    15121 gtcttccgcc gcctcgccaa cttcggccgc tacgtcatcg gcgacacgta cagcaaggag
    15181 aacgagggcc tgtcgggccg cgtcgtgaac gacatcgcgg ccgagcgcgg ccaggacgcc
    15241 ttccagtgcc tggtggagat ctgcgccaac gacgaactgc gcacggtgct ctggccgatg
    15301 cccaccgaca acgacccggc gagctgggcc ctgcgtgccg agacctggca gcacgaggac
    15361 gtcatgctgg gcggctccga cgcgggcgcg cacctggacc gcatgtgcgg ggccccgtac
    15421 acgacccggt tcctcggcga ctgcctgcgc ggccgcaagc tggtcccgct ggagcaggcg
    15481 gtacggatgc tcaccgacga cccggcccaa ctgttcgggc tgcgcgagcg cggccggatc
    15541 gccgagggct tccacgcgga cctggtgctc ttcgacccgg agcgcatcga ggccggcccg
    15601 gcgacgctgg tccacgacct gcccggggac agcccgcggc tggacgcgcg ggccgtcggg
    15661 atcgtctcgg tacgggtcaa cggcgtggag accatccgcg acgacgaagt gacgggcgcg
    15721 atcccgggca tcgtgctccg gtcgggccgg gacacgagga cggtgagcac gcggtgacca
    15781 agctcttcat cggcggcgag tgggtggagc cggagggcgg ccactacgag gtggtcaacc
    15841 cggcggacga gtcggtggtc gggctcgcgc ccgaggcatc accggcgcag gtcgcggagg
    15901 cggcgcgggc cgcggccgag gccttcgggg cgtggtcccg tacgaggccg gaggagcggg
    15961 ccgcgatcct ggaccgggcc gccgacatca tccagcggga gtacgagccg tggacggccc
    16021 tcgcccaggc cgagaccggc gcgccgaccg gcatcgcccg cggcatgcag gtgggggtgg
    16081 gcgtggcccg gttccgccgg tacgcgcgcg gagccctcga acccgtggag aagggcctcc
    16141 cgccgcaggt cacggaggcc ggcccgatgg gcaaggcggg cgtcctcggt gcgctggagg
    16201 tgcgccagcc ggtcggcgtg gtcacttgca tcacctcgta caacaacccg tgggcgaacc
    16261 cggccggcaa ggtcgccccc gccctggcga tgggcaacac ggtggtggtc aaacccgccc
    16321 cgcaggaccc gctgtcggtg ttcaagatgg cggaggcgct cgcggaggcg ggagttccgc
    16381 ccggtgtggt gaacgtggtc aacggtcagt cggtggcggt cggcgaggcc gccgtggact
    16441 ccccggacgt ggacatggtc tccttcaccg gctccacggc ggtcgggcag cgcatcgccg
    16501 aggtgtgcgg gcggaccatg aagcggcagc tgatggaact gggcggcaag ggcgcggcga
    16561 tcgtcttcga ggacgccgac ctggacgcgg cgatgatggg catcggcacc accttctcct
    16621 tctactccgg ccagatctgc accgctccga cccgggtgat cgtgcaccgg tccgtccacg
    16681 acgcgctggt ggagaagctg accggctacc tggccttcat gaaggtcggc gaaccggcgg
    16741 cgcagggcac ggtggtcggc ccggtcatct cggcggccca ccgcgaccgg gtggagtcct
    16801 acatcgagct ggggaagaag gaaggcgccc ggatcgcggt gggcggcgac cgcccggcgg
    16861 tccgggccga cggcaagggc ttctacgtgg ccccgaccct gctggtggac tgcaccaacg
    16921 acatgcgggt ggtccgcgag gaggtcttcg gcccggtcgt cgtggtcgtc cccttcgaca
    16981 cggaggagga ggccgtcgcc ctggccaacg actccgactt cgggctgatc agctacgtct
    17041 ggtcggggga cccgtcgcgc gccttcgggg tggcccgccg gctccggtcg ggcggggtcg
    17101 gcgtgaacac catcggccgg aacatggagg cgccgttcgg cggcttcaag cggtcgggcg
    17161 tgggacgcga cgtcggctcg tacgcgctcc atgcctacag cgagatccag tcgatcgtct
    17221 ggaccacgta gccggcgggt caggccaggt gccggagctt gtcggggttg cggatgaccc
    17281 ggatctcggt gatccggccg ttctcgacct ccacgcaggc gacggtgtcc ggccgcccgg
    17341 ccgtggtgag cagcaggccc ggcaggccat tgacgtcgac ggccacgagc tgcggggcct
    17401 ccatcggctg ggcgagcacg gctgcgagaa aacgagccac gttctcggcg ccgtgcagcg
    17461 ggcgcaaggc tgccctgacc tttccgccgc cgtcgttcca cgcggtgacg tcgggggcga
    17521 gcagctccag catgcggttc aggtcgccgc cgaggcatgc ggcgagaaac tcgtcggtga
    17581 cctggcgcct cacctcggcc ggggccgcgt agcgcggccg acgtgcctgg acgtgcgact
    17641 tggctcggga accgacctgg cgtaccgagg tctcggtgcg gtcgagcgtc tcggcgatct
    17701 cccgatacga gaagccgaag acctccttga gcacgaagac cgcgcgctcc agcggtgaga
    17761 ggctctccag aaccaccagc atggcgagcg agaccgactc ggccaactcc atgtccccgg
    17821 tggcgtccgg cacggtgacc agcggctcgg gcagccaggg gccgacgtac tgctcccgct
    17881 tgacggcggc cgaactcagc cggttgagcg cgaggttggt gatcgtgcgg gccaggtagc
    17941 cgcgcgggtt gtcgaccggg ccgggcacct ggctgcagcg gagccaggtg tcctggacca
    18001 ggtcctcggc gtccgcgacg ctgccgagca tccggtaggc gatgccgaag agcatcggcc
    18061 ggtgctgttc gaagtcggcg atctcgatca cgtacgcgac ggtaccgtgc aggcctcgga
    18121 gaagccctgg ctggtcaggc cgaaggcgct gttcatccgg gagcgccagt tctccagggc
    18181 gaccatggcg gtgagttcca cgaaggcggc ctcgcccagc cgccggagca gcgcttcggc
    18241 gagtccgtcc gtgacgccgg gctcggtctc ggtcatggcc tcggcgtact ccatgacctg
    18301 gagttccagc tcggtgaagg cctcgcgatg gtgccgccac tgcggcacca gagagatctt
    18361 gtcgagcggc aggccgagtt cgctgccttc ccagtgtccg aagtccatgc accaagagca
    18421 gttgatccgg gccgcggtgg ccatcacggc gagatgcctc agggccggct cgagtgcgtt
    18481 ccacttggcg acggagcgct ccagcttgac gtagctgagc aggaccttct ggttgtggcc
    18541 gatcgcgagc ccggggtcga gcacctcgcc gtacttccgc cgggagtacc aggaccccat
    18601 gcggttcagc agggtacggg gcggggcgag cgagatgcgg gcggtcattt cgggcctcca
    18661 ggcttacgga tggatgcttc tggaggtagg acaggacagc tgccgggaat gtgacatcag
    18721 agatgtccta gcggccgtcg gcgaaggtct tcgggtcggc ggtcgcgagg cggtccaggg
    18781 cggcggccgc ctgggcctcg ggcggacggc cgtcgtcccg cagcgtccag tggaagtagc
    18841 gccgcgatcc gccctccgat tccgcttccg tttccgcttc cggccggatg ctgaagccca
    18901 cgtccaccgt gtccggctca cgccaactgg tgccgaccca gcccggttcg acgtcccacc
    18961 gggtcagcag gtccgggcgc tcccgaaggc ctgccttgat cagccgggcc gtgttccggg
    19021 ccggccagca ccaggagcgg tcccgctcgg cgcgcccgac ctcggcgtcg taggcggccg
    19081 cggcgaagcg gtactcgggc ggtgtcggcc cgaccgcccc gcgccagtcg ccccacacca
    19141 cctcgtcgcc gtcccggcgg atggtcacgt acagcgcccc gcaacagcct tcggtgcagt
    19201 acgcctcggc gagctgcacc tcccgcggct cggccccggc gcggagttcg ccggtgtcga
    19261 gcagcaactc gggggagccg gccgggccct tcccgaagtg ctcggtcacc aggggccggc
    19321 catccaccag gatccgggtc tcgacggcgt tcgcttccgc cggatcgcgt acgaccacct
    19381 cgaggcggaa ccgcttcggc gccggcagcc ggacgaacgg ctgccggcgc gtgcgcctga
    19441 tccagtccgc ccgccggcgt gcgtcggcat cctgctgttc ccgtacggat acggcggtcc
    19501 acgcgggccc ggccagcagc cggtccaagg cgtcgaggag cgcctcgcgc tgtcccggcc
    19561 gccagtccag cagcacgccg gggccggtgt ggaggtccag ggcgaggacg agcaggagta
    19621 cgtggtggtc gagggtcggg gacagccggt ccgcgtgccc gaccagcgcc tcgtacacgg
    19681 ccacggccgg cccgtagtcg aggatctcgg cccggtagtc gcgctggctc gccatccggt
    19741 acagcagccg gccggcccgg tcgagcagct cgccgtcctg cggatacgcg cggagcagac
    19801 cctcgaggtc cgcggcctcg gcgatccgcc gggcgagcca gagcacctcc gcgtccggcg
    19861 gcagcgcgac cagagcggtt cgggcgtcct gcgcgtcgcg ggtggagaag gcggcgagca
    19921 gcggggccat ttccggggcc cgggagcggt gggccagcaa cagcagcgcg gccgcctgcc
    19981 ggtcgagcgg gtcgagcgct gcggcagccg cctggccgag gccgcgcagg agcccgagga
    20041 ccttgaggca gggcacgtcc tcgggttcgc cgaggcggat cagcagcgcc aggccgacgc
    20101 tgacggccgc cgtgctggtg ccggtacggg tcagccgccg ggcggtgcgc cgggcggcgg
    20161 cctcgtccgt cagcggcagc cgtccgacgt gcgcgcggag ggtgcggtac ggcatccgca
    20221 gcgcgtcggc acggaggtgg acggcttcgg cggcccgtac gggatccgcg tcggccagca
    20281 acggggcgag ggcggcagcc acttcgtccc ccgcctgggc ccaggtcagg ccgctgcgtc
    20341 ggctgggctc cggcggcccg tcgggcaagg ggtggccgcg gcgcgggaac gggccgtcgg
    20401 ggtcgatgcc ctgccggaac agggcgtagt cgtacaggga ggttccggca gtgagcgccg
    20461 tgcgctcgtc gcgggcgctc acagggcggg gtgggactcg attcggtagg tcatgtgcgg
    20521 agcctgccag gccggttcag ggcgcgtcca acgaaaatac ggcttcgccc cgcacccggc
    20581 cgttgatctg cagctgcacc aggtgctcgc cggagtggta gcggcgggtg gtgatcggct
    20641 tgaaggagtg gcgt
//
