LOCUS       NZ_CP102509            24537 bp    DNA     linear   CON 06-JAN-2024
DEFINITION  Streptomyces sp. NBC_00162 chromosome, complete genome.
ACCESSION   NZ_CP102509
VERSION     NZ_CP102509.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NBC_00162
  ORGANISM  Streptomyces sp. NBC_00162
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8635149)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Joergensen,T.S., Klitgaard,A.,
            Mourched,A.-S., Blin,K., Larsen,T.O., Weber,T., Gotfredsen,C.H. and
            Charusanti,P.
  TITLE     Identification of the biosynthetic gene cluster for pyracrimycin A
            and elucidation of a key reaction during its biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8635149)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/05/2024 18:03:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,275
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,805
            CDSs (with protein)               :: 7,805
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 371
            CDSs (without protein)            :: 370
            Pseudo Genes (ambiguous residues) :: 0 of 371
            Pseudo Genes (frameshifted)       :: 186 of 371
            Pseudo Genes (incomplete)         :: 231 of 371
            Pseudo Genes (internal stop)      :: 27 of 371
            Pseudo Genes (multiple problems)  :: 68 of 371
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:41:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3479930
            Orig. end                         :: 3504467
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24537
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="25"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24537
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24537
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14537](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14537)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(80..1036)
                     /locus_tag="JIW86_RS15970"
                     /old_locus_tag="JIW86_15970"
     CDS             complement(80..1036)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266319.1"
                     /locus_tag="JIW86_RS15970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15970"
                     /product="ABC transporter permease"
                     /protein_id="WP_215145097.1"
                     /transl_table=11
                     /translation="MRDTTTVGDELTDTQTTGAPATSAPVKGNGKKKKDREASLWSDAI
                     RDLRRNPIFLIGTVLVLAMLVLSAVPQWFTDGSPFDATACTLQNSLKTPSADHWFGFDI
                     QGCDVYTRTVWAARNSVIVGVVTTTLVIIVGGGLGLLAGWLGGIADSVLSRFAEIFFAL
                     PLLLGGMLIMSALPGNAWTVSIVLATLGWPQIFRIMRSSVLQNKNNDYVMAARALGAGA
                     WRITIRHILPNAVAPVIVVGAISLGVYISAEAALSYLGIGVQPPEISWGLMVSDASVRW
                     LQAPHVLLFPAGALSITVLAFIMVGDAVRDALDPKLR"
     gene            complement(1029..1976)
                     /locus_tag="JIW86_RS15975"
                     /old_locus_tag="JIW86_15975"
     CDS             complement(1029..1976)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550237.1"
                     /locus_tag="JIW86_RS15975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15975"
                     /product="ABC transporter permease"
                     /protein_id="WP_215145095.1"
                     /transl_table=11
                     /translation="MGRYLIRRLIQAIPVLLGATFLIYTLTFHMPGADPIQLLAGDKKA
                     DPLVAAMLREKYHLDDPFLMQYWNYISGVFQGDLGETLTGRKVIDLITEAFPYTVNLGL
                     IAFIMEAIVGVLAGVMAALRRGKFLDQLVLLSTLMVISIPVFVTGFVLQLTLGVELKDA
                     WGIDFFPVSFNEADGIRAYLLPAFVLASTSLAYVARLTRTSLMETMRADYVRTATAKGL
                     PRRRVVVNHALRNALIPIVTFLGADLGGLMGGAVITERIFNIHGLGGLLAQSVYLKQGA
                     VVVGGVTLLVLIYLVANLLVDLLYAVLDPRIRYA"
     gene            complement(2073..3695)
                     /locus_tag="JIW86_RS15980"
                     /old_locus_tag="JIW86_15980"
     CDS             complement(2073..3695)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008737265.1"
                     /locus_tag="JIW86_RS15980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15980"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_257554332.1"
                     /transl_table=11
                     /translation="MRGATSAKWVAGAVIVAMAATACSTSKDEAGSKSGGNITVVLGEP
                     QHGLVGQNTAESEGAEVLNALFKGLVEYDNKTNEPKLAVAESITTTDSKTWTIKIKDGF
                     TFHNGEKVDAQSFVRAWNWGANQDNAAEGLPFYDKIEGSEELAPGKDKKPTATELKGLK
                     VVDEKTFTVSLKAPFSQFKTMLGYNAFYPLPKAFEADPKKFGEAPIGNGAFQMDGTWEH
                     NKQIKIKRYDKYPSEGRAKLEGVTFKIYDNLDTAYNDLRADTIQIVDKLPISAMATVSQ
                     EFGDRYLYKPESGVGYIGLPLKTNPEAFGKVEIRKAISMAIDREAITKTIFNGTRKPAD
                     DFISPIVPGYRKGALGEVGTYNPTKAKELYTQAGGIPGNKLELGYNADGGHKEWIEAVG
                     NQLKANLGIEVTAKPFTKFGDMLTELGDQKYKGAFRMAWSMDYPAAENYLRPIFSKIAI
                     DNGSNYGAYVNEEFETVMDNADKATDPAEGLKLYQQADDIIIKDLPYIPVFTYMSSSAY
                     SKSVKNVEIDAQGRMDLATVELN"
     misc_feature    complement(3760..3771)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.68"
                     /tool="antismash"
     misc_feature    complement(3924..3941)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    4027..4042
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            complement(4057..7368)
                     /locus_tag="JIW86_RS15985"
                     /old_locus_tag="JIW86_15985"
     CDS             complement(4057..7368)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523489.1"
                     /locus_tag="JIW86_RS15985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15985"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_257554333.1"
                     /transl_table=11
                     /translation="MFHYRVLGPLDVRRAGESIAITAPKERDLLALLLLNADRPVPAEE
                     LIDGIWGGEPPSTARTTLQNYVKRLRHALHGCRADGEVLATQPGGYVLRLDHGVLDLRE
                     FELLTRGAAEASERGDDATASARLRAALALWQGEALAGSRADRLTQVEAPRLNESRMVA
                     FENRVQADLRLGRHADVIIDVQSAIVGHPLRERLHGQLMLALYRSGRRGDALTAYQQAR
                     AQLVHDLGLEPGPELAALHRRVLAGDPELLEPRAPRTEPGASRAAGRSAGAASGQLSGQ
                     APPAQLPGSTPAFAGRADVLRRLDAMLPAGGTVPSGVVRIGLITGQGGAGKTALAVHWG
                     HRRRDAFPDGQLYVNLRGHDAGRPLRSIDALGGFLQAFGVPAQHIPVEEDRAAALYRSL
                     CAGKRMLVVLDNARCADQVRPLFPGSSECLVLVTSRDSLAGLVAREGAAPLPLRTLEPG
                     EAEEVLLNIIGAARVHAEPEAAAVLTAACAYLPLAVAITAADLAVHPDRSLADQAARLA
                     GDRLGALQVPGDEGTAVRAVLDMSFATLSPAAARMFRLFGMVPGCDVPLRAAAALAGAE
                     LPAAARLLEELVRSHLLEEHAPGRFTFHDLLRAYAVERVREQEGEEGQAAALDRLHSWY
                     LGSTDNAVRLLQPETVRLPVEAAGEALGFDGAGEALEWMDAERPNAVALVQRAAEHGPR
                     QLAWTLADALRPYMMRRAYAVDWLAVGTAGLAAAEADGNLAGQAAAHRSLSSAYLNQSD
                     YDRSMVHDHRALELYRATGSTQGQSSAHNSLCIATWYVGDLNCALLHGEQCLELSRSTG
                     FLVGEAITMGNVGAILHETGRLAEAEERLIQALARYEELGLQTAMAIAERNLGAVLFES
                     GQAQRARGALERAAAMQRRLGNETDLAYTFFWLALTMIQSGDRAGALDHIDQGFEIATG
                     EARAESYLYVGRALLSQSLGNHGTALHHFGTARDLARRCNARTPELRALLGLAESSLRL
                     GRHTEAAGFAEAAREPASRSGYGLFHAKALILLAELDLNGGEFEASARRAGQAVDLQPE
                     AGHRAGRADALVVLGHARRGAGDEKGALRSWTDALDLYEALGAGPAGELCALMAR"
     gene            7508..8185
                     /locus_tag="JIW86_RS15990"
                     /old_locus_tag="JIW86_15990"
     CDS             7508..8185
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523488.1"
                     /locus_tag="JIW86_RS15990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15990"
                     /product="response regulator transcription factor"
                     /protein_id="WP_257554334.1"
                     /transl_table=11
                     /translation="MTKSAPDQNNLRVALVERHPLLRAGIRSALDSAGGIEVVAEAGEF
                     DHVVPLVLSAAPDVVLMDLDLPGSASVEVCRTLVRDAGVRGILGMTGHGDDERLLRAAL
                     MAGVRGYVSKSAGAAEMIGAVHMVGNGFMVASDSAARLVTGLLWAPGRAAEHDPLPMLT
                     RREREILDLVARGYDNRRIARALTLAEKTVRNHVSAVFAKIGVNCRAQAVVYGREAGMG
                     LTA"
     gene            complement(8238..10004)
                     /locus_tag="JIW86_RS15995"
                     /old_locus_tag="JIW86_15995"
     CDS             complement(8238..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="JIW86_RS15995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15995"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257554335.1"
                     /transl_table=11
                     /translation="MSRLGVRALRLLWGISPRQVLSVSVISLVSALLPAVQVYFTARMV
                     QAVVDAVSRGTGTAPALTAGGCLAGVAVVSHFLAVFQDHQQALLRSRLPEAVGLSVMEK
                     SARLSLRQFEDPDTYDRLQRATRESAFRPLQVFTHLIAVGSAAVSFLSVGAVLLGTSVP
                     VALAICLAPVPAALVSLYFSRRTHAVEHARSEGRRRLTYLEHLLTNDQTYKETRLFGLV
                     PLLLGRSRTLVDEFHATDRRIEHRRALFSALFGLLSAGTTAVAILLAVRSALGTGQVGV
                     LAGYIAGVTLIQASVRGLFASGVQLYENCLFLSHLFAFLDMAEEPSEPDGLPVPTVLRR
                     GIEFQNVSFRYPGDERAVLDGVSFTVPAGACVALVGRNGAGKSTLLKLLTRFYEPTGGR
                     ILLDGRPLTHYALSELRDSIGVIFQDYQQYEAPVRENIGFGRVSALDDDQLLWEAAETA
                     GARDILAGLPRGLDAQLGRWFPGGHQLSGGQWQKVALARAVVRRAPIMILDEPTAAIDA
                     AAEAEVFDVLRSVHTRATSLLVAHRFSAVRTADHIVVLDGGRVLEEGSHDELMAADGLY
                     ASLFDLQAAGYH"
     gene            complement(10001..13195)
                     /locus_tag="JIW86_RS16000"
                     /old_locus_tag="JIW86_16000"
     CDS             complement(10001..13195)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="JIW86_RS16000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16000"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_257554336.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.5e-162,
                     bitscore: 540.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.2e-13,
                     bitscore: 49.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-32, bitscore:
                     112.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLYTPAGFFLVRSPALPVDPYVEALDGRGRGARDHLWTLGEQPL
                     VRQAVRVASHSLAEELEKSAPGADSRAADRMHSSLLRYLSRMSSRPTPYGLFAQVEAGE
                     FGEATTLARTGEHPAAGRTRADMGWLMALVKEMEGDPELRGELTVGVNPLLQRTGDRIT
                     LAVAQTSVTADQQSSSVRATRAVDAVLARAAARPRWSELIAALAGEFPAAPPAKITALM
                     DQLWDLGMLTSDLRPALTHPCPEQAVLDRIEGLAGAGRYRRALRRTRQLAAAADQAPPE
                     EGSRLLAELYDHQRVVVPGHTQSPFHADARLDLRGTTLHSQVADAAAEAADVLLRLGQQ
                     TPRLHHLAVYHREFLERYGVGAEVPVLDLLNPETGLDAPETYRYPPRELPLTPSPRKDR
                     REQEEALAALAAAALHQGKREVEITDAFLKAWQPRDDGGSGPDARPSLDIMGQVVAGSR
                     GQLDDGDWKFVLSTGPMRDGGRFGGRFFDLLGENFQKLLQEYATAEEELCTATVFAELN
                     YAQLEGRRGNVAVHPPVRRYEICVNASPTGGDVQQIDLSDVLVGATPDRFYLRSARLDR
                     QLHVTQSHLVNWGSAPNVCRFLLEASEDGWAPLAEFSWGAMERAPFLPRVTRGRIVLKP
                     ARWLFGSDVPGFPDGCADAAAMDREAFFDAFGQWRQAWQVPRWVHLSLFDHRILLDLEN
                     PLCVDELQRALRTSYGPGGPGALVLEESVADPAQPSWLRDADGRSYANEIVVPLLARKT
                     AVETPVPVVSPAAALAARELAADPARAKRQTAGGDWAHVKLYAAAARHEDILSGSLPEL
                     IRGLREEGLIDRWFFIRYGDPHPHLRIRVRRAPGADASAPLVRLVGWAKGLVDAGLAAD
                     LAVVSYDRETERYGGPLVMDAAEAVFEAGSDMATALLGLLRSRPGLDADIVGAYALDAL
                     HRQWGAAPDGGHGLAGKEIPSATRERFRTVRRTLCDLIAPWDERPDPLAREWADALGTV
                     LAVQADVVADAGRLVRSLAESGQLIGTEREILGSLAHMQSIRLQGLDREREVRCGHLRA
                     LALRAVQGRRAAGGRR"
     aSDomain        complement(12482..12745)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JIW86_RS16000_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="8.00E-16"
                     /identifier="RREFam001.1"
                     /label="JIW86_RS16000"
                     /locus_tag="JIW86_RS16000"
                     /protein_end="238"
                     /protein_start="150"
                     /score="49.5"
                     /tool="antismash"
                     /translation="VNPLLQRTGDRITLAVAQTSVTADQQSSSVRATRAVDAVLARAAA
                     RPRWSELIAALAGEFPAAPPAKITALMDQLWDLGMLTSDLRPA"
     gene            complement(13221..14537)
                     /locus_tag="JIW86_RS16005"
                     /old_locus_tag="JIW86_16005"
     CDS             complement(13221..14537)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="JIW86_RS16005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16005"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_257554337.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-43, bitscore:
                     148.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITGPLAGQARRTAHLIASRLADAGYVADRVAASTADPNTSGARR
                     ASSLLAGDAGIAMVLRLASEADPESGDHWRRAAHGTLTRAVRSTHDRPLFGHGIVGGSA
                     GLALALSEFAAGDQRYQRPLDSLHTRLADQLGARDKPAVGSHASIAEYDALQGAAGTLG
                     YLLSVPGPDAALRDGVHGLVDELVRLCTPAPAEAESRWVVPPEDYPLLPRDLEEYPHGY
                     INLGLAHGIPGPLAALSLAWRAGYRRPGLREAIGNGIALLSSAAVEDGFGIDWPSGIAM
                     DPEGRRTQARHPARTAWCYGAPGIAAALLIAADALEDEELRAYAVAAFEAALRRSEEHI
                     HTLSPTICHGLAGLLAICEVFARTTDSVQARAALPVLTERLLAHCSEDLAFGVQNLERP
                     DLRIDNPDFLCGAAGVAAVLWTVSAPAPRRRWQRALLIA"
     gene            complement(14534..15634)
                     /locus_tag="JIW86_RS16010"
                     /old_locus_tag="JIW86_16010"
     CDS             complement(14534..15634)
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012888.4"
                     /locus_tag="JIW86_RS16010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16010"
                     /product="sulfotransferase domain-containing protein"
                     /protein_id="WP_322975527.1"
                     /transl_table=11
                     /translation="MPRTAATRRQRSLPALSADNDREAACPFRAGRRTHVKGRPEVSSE
                     RVFVISPRKSGTHLVQELLVHLGYRIYGEPVPPSAGRPAFSIRERLEMAEKFLDPAEFE
                     ALDHERDRDAFIRTTDEVWLQLAWAWQTRLAVAPLAHVEAMAPEARFGPKMRPEIWTAP
                     FSSTPAGVSWIFHSVDVWRMDSSFLAEWVNTGSPKVILNYRDPRDVLVSLVDFFSRNNG
                     LKFMRYPESAIFGPVLESIEDYGKKLDYALSDPQMPLLSDFESAISFLHHPNVCHVSFE
                     DLVGPQGGGSRAAQLAAVGRVADWLDHDVDPESVVDRLFNPQSFTLNKGRTGRWRESFS
                     PAHVERFEARFGHLLDSFGYAREAGQ"
     gene            complement(15579..15773)
                     /locus_tag="JIW86_RS16015"
                     /old_locus_tag="JIW86_16015"
     CDS             complement(15579..15773)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="JIW86_RS16015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16015"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_257554339.1"
                     /transl_table=11
                     /translation="MSVSLVEPVVQDHGLDDFDLDVRIAVSSDIPSIEGGFSNWYSCKG
                     TCASYCCDQEATLITCAVC"
     CDS_motif       complement(15678..15773)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSVSLVEPVVQDHGLDDFDLDVRIAVSSDIPS"
                     /locus_tag="JIW86_RS16015_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15579..15677)
                     /prepeptide="core"
                     /locus_tag="JIW86_RS16015_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-2.10"
                     /molecular_weight="3319.7"
                     /monoisotopic_mass="3317.4"
                     /core_sequence="IEGGFSNWYSCKGTCASYCCDQEATLITCAVC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSVSLVEPVVQDHGLDDFDLDVRIAVSSDIPS"
                     /leader_location="[15677:15773](-)"
     misc_feature    complement(15596..15598)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16155..16170
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.25"
                     /tool="antismash"
     gene            complement(16167..17531)
                     /locus_tag="JIW86_RS16020"
                     /old_locus_tag="JIW86_16020"
     CDS             complement(16167..17531)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04267.2"
                     /locus_tag="JIW86_RS16020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16020"
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_257554340.1"
                     /transl_table=11
                     /translation="MARFVLGLQLLAQKDARHPDALRRLSLLSREQLLPLLGDPVLRNV
                     FEDDMAKLENGHSGALGLAELAARLPLDPDGLGPCERMATPHVRPWPEHGPAWLWTEMS
                     PADRVPGDLSARLRRLYDGSIEGGPAADPVIPTPEMCRALTRGADLLTRLLPQVGPSVL
                     RHVSVVGFTRGESADGPLQSLSGGDPLPSAILMAPERLDDPWTAAETLLHEGVHLKLFD
                     ALRSGALLKDADLSVPIPWRQTQWRLVRVLVALHFYVHMLVFQEAARHADDTLRAQFGD
                     PPSGEVIDAVSPDTEAARNGTYGSSLERARYLAEYALGLPEGRLTADGRRFLSWLLDAL
                     HLVHEDSGITPPTGVAGVAPAQPPAVPEGVVVRRTTCAMARPLPERGELLVVNTDTAAM
                     HWLNARSWLIYSLCDGRDVGSVRDEYGRRAGLDSESARTQVDACLSELTAAGLVR"
     gene            complement(17727..17864)
                     /locus_tag="JIW86_RS16025"
                     /old_locus_tag="JIW86_16025"
     CDS             complement(17727..17864)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS16025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_16025"
                     /product="hypothetical protein"
                     /protein_id="WP_257554341.1"
                     /transl_table=11
                     /translation="MPQLEIEFPAIAQNWLAAESVPQIGRDSGEERAWVPAYWAGPAAA
                     "
     gene            complement(18067..19971)
                     /gene="typA"
                     /locus_tag="JIW86_RS16030"
                     /old_locus_tag="JIW86_16030"
     CDS             complement(18067..19971)
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /GO_process="GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="typA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008737269.1"
                     /locus_tag="JIW86_RS16030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16030"
                     /product="translational GTPase TypA"
                     /protein_id="WP_257554343.1"
                     /transl_table=11
                     /translation="MPTRHDIRNVAIVAHVDHGKTTIVDAMLKQAGAFAAHQHLDDRMM
                     DSNDLEREKGITILAKNTAVKYHPKDGGAPITINIIDTPGHADFGGEVERGLSMVDAVV
                     LLVDASEGPLPQTRFVLRKALQAKMPVILCINKTDRPDSRIDEVVNETYDLFLDLDADE
                     DQIEFPIVYACGRDGVASLTKPEDGTVPADSTNLEPFFSTILEHVPAPVYDDEAPLQAH
                     VTNLDADNFLGRIALVRVEQGELRKGQTVAWIKRDGTISNVRITELMMTEALTRKPAEV
                     AGPGDICAVAGFPDIMIGETLADPENPIALPLISVDEPAISMTIGTNTSPMVGRGGSGK
                     GADAKSAVKDRKVTARQVKDRLDRELVGNVSLRVLDTERPDAWEVQGRGELALAILVEQ
                     MRREGFELTIGKPQVVTQEINGKVHEPVERMTVDVPEEHMGAVTQLMGVRKGRMDNMSN
                     HGSGWVRMEFVVPSRGLIGFRTEFLTGTRGTGIAHSIHEGLEPWFGPLVTRNNGSLVAD
                     RSGSVTPFAMINLQERGVLFTEPGTEVYEGMIVGENSRADDMDVNITKEKKLTNMRAAS
                     ADNTENVVPPRKLSLEQSLEFCRDDECVEVTPEAVRIRKVVLDQKDRSRTASRAKSGK"
     gene            complement(20318..22678)
                     /locus_tag="JIW86_RS16035"
                     /old_locus_tag="JIW86_16035"
     CDS             complement(20318..22678)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239903.1"
                     /locus_tag="JIW86_RS16035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16035"
                     /product="ABC transporter family substrate-binding protein"
                     /protein_id="WP_257554344.1"
                     /transl_table=11
                     /translation="MSQRRRRSLALLTSGVLALPLLTGCGAGDDEGGPAAAGPDIATTA
                     RDKVADGGVLRWAVDALPETLNTFQADADATTNRIAAAVLPQLFVLDAKGRPVANPDYL
                     EKAEVVEREPKQVVLYKLNQQAVWSDGREIGAPDFVAQWRALNGKDSAFWTARNAGYER
                     IEKIERGKTDLEVKVTFAKPYADWRSLFSPLYPKQVTATPDAFNEGARGALKVTAGPFG
                     LGTIDKKTGTAALTRNPRWWGQPAKLDTLVLTAVPRAERPAALAAGKLDLAEIDRSGAD
                     RIALAHRDAKQGGAGAGGAGAGGAPAHGPAASMTAAQATMSWAVAFGADEEKAEAEKET
                     RKKHAESVTRYAAEQEALRRFTIRKSLEPAYTQLAMNGATGPLADERVRRAVARALNRK
                     ELAEIVLKPLGLPAKPVGSHLALAGQRAYADNSDALGGQDTQAAQALLADAGWRRGGKI
                     TEPAGAKAGPESAPQDDSKTPSGPGTGNDGLYIVGQDDERNGDHGGTHGALPEGAQYGP
                     DGEIVDADVFAPDAPGAARNRPSPVLAPAPFAARQEAFLRAQAAAAGSVDDGKDGKDGE
                     AAEPADPAKGTAPPAKQATRTSGAMLAKDGKALNLRFVLPAGPGSEALRSVGERIAQML
                     RKVGVNTEIKKVADESFFKDHIASGQYDLALYSWPATAYPATDARPIFAKPEPAADGSL
                     LVEQNYTRVGTDHIDQLFDQAAGELDEEQSRELMRKADARIWAAAGSVPLYQRPELVAV
                     KPALANAGAFGLGAPRFQDIGWKKPPTAKNKKQ"
     misc_feature    complement(22879..22893)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     gene            23028..23261
                     /locus_tag="JIW86_RS16040"
                     /old_locus_tag="JIW86_16040"
     CDS             23028..23261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480660.1"
                     /locus_tag="JIW86_RS16040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16040"
                     /product="hypothetical protein"
                     /protein_id="WP_257554345.1"
                     /transl_table=11
                     /translation="MSLQDDLNAVRRNLDELTRKVEQLEQQAKRKDPASPRTGSAPPDP
                     SRMVTVPDTPYDSSLWTDTDDEGLGARDRRAP"
     gene            23364..24188
                     /locus_tag="JIW86_RS16045"
                     /old_locus_tag="JIW86_16045"
     CDS             23364..24188
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983797.1"
                     /locus_tag="JIW86_RS16045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_16045"
                     /product="hypothetical protein"
                     /protein_id="WP_215146042.1"
                     /transl_table=11
                     /translation="MATGTQPPQQRPGGVHDASRAAIAARHLRTDRWWLAPAGTAAGLL
                     AFIVYSTWRAFANADYYAAPYVSPFYSPCLAENCQEMRGGPNWDLFGSWWVLSPALLIL
                     IFPLGFRLTCYYYRKAYYRGFWASPPACAVAEPHAKYTGETRFPLIFQNAHRYFFYTAL
                     PVAGILTYDTVLTFRDEHYEWGHMGLGTLIFLVNIVLIWAYTVSCHSCRHIMGGRLKHF
                     SKHPVRYRLWGWVSRLNTRHMQLAWASLVSVALCDFYVYLLATGAFTDPRIF"
ORIGIN
        1 cagcgggatg ccctccggcg ccgagcgggg cgcggggacg ttcgaggtct tgtcgatgat
       61 ggtcaacgta cgcccttcct cagcgcagct tcgggtcgag ggcgtcgcgc accgcgtcgc
      121 cgaccatgat gaacgcgagc accgtgatgc tcagcgcgcc ggccgggaag aggagcacgt
      181 gcggagcctg gagccagcgg acggaagcgt cgctgaccat caggccccag gagatctccg
      241 ggggctggac gccgataccg aggtacgaca gggccgcctc ggcggagatg tacacaccca
      301 ggctgatcgc gccgaccacg atgacggggg cgacggcgtt cggcaggatg tgccggatcg
      361 tgatgcgcca ggcgccggcg ccgagggcgc gggcggccat cacgtagtcg ttgttcttgt
      421 tctgcagcac cgaggaccgc atgatgcgga agatctgcgg ccagccgagg gtggccagaa
      481 cgatggagac cgtccaggcg ttgccgggca gggcggacat gatcagcatg ccgccgagga
      541 gcagcgggag cgcgaagaag atctcggcga agcgggacag cacgctgtcg gcgattccgc
      601 cgagccagcc ggccagcaga ccgaggccgc cgccgacgat gatcaccagg gtggtggtga
      661 cgacgccgac gatcacggag ttccgggccg cccagacggt acgcgtgtag acgtcgcagc
      721 cctggatgtc gaaaccgaac cagtggtccg cgctcggggt cttgagcgag ttctgcaggg
      781 tgcaggcggt ggcgtcgaac gggctgccgt cggtgaacca ctgcggcacg gccgacagga
      841 ccagcatggc cagcaccagc acggtgccga tcaggaagat cgggttgcgg cgcaggtcgc
      901 ggatcgcgtc ggaccagagg ctggcctcgc ggtccttctt cttcttgccg ttgcccttga
      961 ccggggcgct cgtggcgggg gctccggtgg tctgggtgtc ggtcaactca tcccccaccg
     1021 tagttgtgtc acgcatagcg gatcctcggg tcgagcacgg cgtacagcag gtccaccagc
     1081 aggttggcga cgaggtagat gaggaccagg agcgtcacac cgccgacgac gacggcgccc
     1141 tgcttgaggt acacggactg ggcgagcaga ccgccgaggc cgtggatgtt gaagatgcgc
     1201 tcggtgatga ccgcgccgcc catgaggcca ccgaggtcgg ctccgaggaa cgtgacgatc
     1261 gggatgagcg cgttgcgcag cgcgtggttc acgacgacgc ggcgacgggg caggcccttc
     1321 gcggtcgcgg tgcggacgta gtccgcgcgc atcgtctcca tcaggctggt ccgggtcagt
     1381 cgggccacgt acgccagcga ggtcgaggcg aggacgaacg ccgggaggag ataggcacgg
     1441 atgccgtcgg cctcgttgaa ggagaccggg aagaagtcga tgccccaggc gtccttgagc
     1501 tccacgccga gcgtcagctg cagcacgaag ccggtgacga agacggggat ggagatgacc
     1561 atcagggtgg acagcagcac cagctggtcg aggaacttcc cgcggcgcag cgcggccatg
     1621 acgccggcga ggacgccgac gatggcctcc atgatgaaag cgatcagacc gaggttcacc
     1681 gtgtacggga acgcttcggt gatgaggtcg atcaccttgc ggccggtgag ggtttcaccg
     1741 aggtcgccct ggaagacgcc gctgatgtag ttccagtact gcatcaggaa cgggtcgtcg
     1801 aggtggtact tctcgcgcag catcgccgcg acgagcgggt cggccttctt gtcacccgcg
     1861 aggagctgaa tcgggtcagc tcccggcatg tggaaggtca acgtgtagat caggaacgtg
     1921 gcaccgagca gaacagggat cgcctgtatg agtcggcgga tgaggtagcg gcccatcaga
     1981 cctccagcag aagagcaggg ggaaggggca gacagacgga aacctgattc cgtctgcccg
     2041 cccccgttgt ccccttggtg tgaagaaggg tgttagttga gctcgaccgt ggccaggtcc
     2101 atgcggccct gggcgtcgat ctcaacgttc ttcacggact tggagtaggc cgaggaagac
     2161 atgtaggtga agaccgggat gtacggcagg tccttgatga tgatgtcatc ggcctgctgg
     2221 tacagcttga ggccctctgc cgggtccgtc gccttgtcgg cgttgtccat gacggtctcg
     2281 aactcctcgt tgacgtaggc accgtagttg gagccgttgt cgatcgcgat cttggagaag
     2341 atcggacgga ggtagttctc ggccgccggg tagtccatgg accacgccat gcggaaggcg
     2401 cccttgtact tctggtcgcc cagctcggtc agcatgtcgc cgaacttggt gaacggcttg
     2461 gcggtgacct cgatgccgag gttcgccttc agctggttgc cgacggcctc gatccactcc
     2521 ttgtggccgc cgtcggcgtt gtagccgagc tccagcttgt tgccggggat gccaccggcc
     2581 tgggtgtaga gctccttggc cttggtcggg ttgtacgtac cgacctcacc cagggcgccc
     2641 ttgcggtagc ccgggacgat ggggctgatg aagtcatcgg ccggcttgcg ggtgccgttg
     2701 aagatggtct tcgtgatggc ttcccggtcg atggccatcg agatggcctt gcggatctcg
     2761 accttgccga acgcctcggg gttcgtcttc agcgggagac cgatgtagcc gacgccggac
     2821 tcgggcttgt agaggtaacg gtcgccgaac tcctgggaga cggtggccat cgccgagatc
     2881 gggagcttgt cgacgatctg gatggtgtcg gcgcgcaggt cgttgtacgc ggtgtccagg
     2941 ttgtcgtaga tcttgaaggt gacgccctcg agcttggcgc gaccctcgga ggggtacttg
     3001 tcgtacctct tgatcttgat ctgcttgttg tgctcccagg tgccgtccat ctggaaggcg
     3061 ccgttgccga tcggggcctc gccgaacttc ttcgggtcgg cttcgaaggc cttcggcagc
     3121 gggtagaagg cgttgtagcc cagcatcgtc ttgaactggg agaacggagc cttcagcgag
     3181 acggtgaagg tcttctcgtc gacgaccttc aggcccttga gctcggtggc ggtgggcttc
     3241 ttgtccttgc ccggcgccag ctcctcggag ccctcgatct tgtcgtagaa gggcaggccc
     3301 tctgcggcgt tgtcctggtt ggctccccag ttccaggcgc ggacgaacga ctgcgcgtcg
     3361 accttctcgc cgttgtggaa ggtgaagccg tccttgatct tgatcgtcca ggtcttcgag
     3421 tccgtggtgg tgatggactc ggcgaccgcg agcttcggct cgttggtctt gttgtcatac
     3481 tcgacgaggc ccttgaagag cgcgttgaga acctcagcgc cttcggactc ggcggtgttc
     3541 tgaccgacca gaccgtgctg cggctcgccg agcaccacgg tgatgtttcc accggacttg
     3601 ctgccggcct cgtccttgct ggtgctgcag gccgtggcag ccatcgccac gatgacggca
     3661 cccgcgaccc acttggcgct cgttgctccg cgcatgggta attgcctcct caggagtcac
     3721 tgtcgatacg tgaagggccc ggcactcgct gacacccctg acagcgattt ccggccccat
     3781 cgtgtgtgct cgtgagtcgg cgctccccac agcgcgtgac ccattgaccc gagctcaatg
     3841 gagccatcct cagggacgcc tagaccgtaa accacactta agtggtctcg ttttcacaac
     3901 atcgccccat gtcgaaaacc cgaaatccgg acaaacggat aggagacaga cacgtgcgaa
     3961 acggacggtt agttcacctt ccggagcgtc acggtcggta tgcggacacg tgaaccccta
     4021 aatccgcttg acaaaagtga acgtcacacc gctctgtcaa cgggccatca gggcacacag
     4081 ttccccggcc ggcccggcac cgagagcctc gtacaggtca agggcatccg tccaggaccg
     4141 cagggcccct ttctcatcac ccgcaccccg ccgggcgtgc cccaggacga ccagggcatc
     4201 ggcccggccg gcccggtggc cggcctccgg ctgcagatcg accgcctgcc cggcccgtcg
     4261 cgcggaggcc tcgaactcgc cgccgttcag gtccagctcg gccagcagga tcagcgcctt
     4321 ggcatggaac agcccgtatc cgctgcggct cgccggctcc cgcgccgcct ccgcgaaccc
     4381 ggccgcctcc gtgtgccgcc ccagcctcag gctgctctcg gccagcccca gcagggcccg
     4441 gagctcgggg gtacgggcgt tgcagcgccg ggccaggtcg cgcgccgtac cgaagtggtg
     4501 cagggcggtg ccgtggttgc cgaggctttg cgagagcagg gcccgcccga cgtacaggta
     4561 cgactccgcg cgcgcctcac cggtcgcgat ctcgaaccct tgatcgatgt ggtcgagggc
     4621 gcccgcccgg tcgcccgact ggatcatggt cagagcgagc cagaagaagg tgtatgcgag
     4681 gtcggtctcg ttgccgaggc gtcgctgcat cgcggccgcc cgttcgaggg ctccacgcgc
     4741 ccgctgcgct tgcccgctct cgaagaggac cgccccgaga ttgcgctcgg cgatcgccat
     4801 ggccgtctgg agccccagct cctcgtagcg ggccagtgcc tggatcagcc gctcctcggc
     4861 ctcggccagc cgacccgtct catgcaggat cgcccccacg ttgcccatcg tgatcgcctc
     4921 gccgaccagg aagcccgtac tgcgggagag ctccagacac tgctcgccgt ggagcagggc
     4981 acagttcaga tcgcccacgt accaggtggc gatgcagagg ctgttgtggg cggagctctg
     5041 gccctgcgtc gatccggtcg cacggtagag ctccagagcc cggtggtcgt ggaccatgga
     5101 cctgtcgtag tcgctctggt tcaggtacgc gctcgacagg ctgcggtgtg cggccgcctg
     5161 gccggccagg ttcccgtccg cctcggccgc ggcgaggccc gccgtcccga cggcgagcca
     5221 gtcgaccgcg taggcccgcc gcatcatgta cgggcgcagg gcatcggcca gggtccacgc
     5281 gagctgccgc ggaccgtgtt ccgcggcgcg ctgcaccagg gccacggcgt tcggccgttc
     5341 cgcgtccatc cactccaggg cctcaccggc gccgtcgaag ccgagcgcct cgccggcggc
     5401 ctccacgggc aggcgcacgg tctcgggctg cagcagccgc acggcgttgt cggtgctccc
     5461 caggtaccag gagtgcagcc ggtccagggc ggccgcctgc ccctcctccc cctcctgttc
     5521 ccggacccgt tccacggcat aggcgcgcag cagatcgtga aaggtgaacc ggccgggcgc
     5581 gtgctcctcc agcaggtggc tccggaccag ctcctccagc agccgggcgg cggcggggag
     5641 ctccgcaccg gccagcgccg cggcggcccg cagcgggacg tcgcaaccgg ggaccatccc
     5701 gaagagacgg aacatccggg cggcggccgg cgagagcgtg gcgaaggaca tgtcgagcac
     5761 tgcgcggacg gcggtcccct cgtcccccgg aacctgcagt gcccccagcc ggtccccggc
     5821 cagccgggcc gcctggtcgg cgagggaccg gtccgggtgg acggccaggt cggccgccgt
     5881 gatcgcgacg gcgagcggca ggtaggcgca ggcggcggtg aggacggcgg ccgcctcggg
     5941 ctctgcatgg acccgggccg caccgatgat gttgagcagt acttcctcgg cctcgccggg
     6001 ttccagtgtc cgcagcggca gcggagccgc gccttcccgt gcgacgaggc cggccagcga
     6061 gtcccggctg gtgacgagga ccaggcactc cgagctgccc gggaagagcg ggcggacctg
     6121 atcggcgcag cgcgcgttgt ccaggacgac gagcatccgc tttcccgcgc acagggagcg
     6181 gtagagcgcc gccgcccggt cctcctccac cgggatgtgc tgcgccggca cgccgaaggc
     6241 ctggaggaag ccgccgagcg cgtcgatgga ccgcagcggc cggcccgcat cgtgaccgcg
     6301 gaggttgacg tagagctgtc cgtccgggaa ggcgtcccgt ctgcgatggc cccagtggac
     6361 cgcgagggcc gtcttccccg cgccgccctg cccggtgatc agcccgatcc gcaccacccc
     6421 agaaggcacg gttccgccgg ccggcagcat cgcgtcgagc cggcgcagta cgtccgctcg
     6481 cccggcgaag gccggtgtgg atccgggcag ttgggcgggc ggcgcctgcc ccgacagctg
     6541 cccggacgcc gcgcccgcgg agcgccctgc ggcccgcgac gcgcccggct cggtccgcgg
     6601 cgcgcgcggc tccaggagtt ccgggtcgcc ggccaggacg cgccggtgca aggcggccag
     6661 ttccgggccg ggctccagtc ccaggtcgtg gaccagttgg gcgcgcgcct gctggtaggc
     6721 ggtgagcgcg tcgccccggc ggcccgagcg gtacagggcg agcatcagct ggccgtgcag
     6781 ccgctcccgc agcgggtggc ccacgatcgc ggactggacg tcgatgatga cgtccgcatg
     6841 acggcccagc cgcaggtccg cctggacccg gttctcgaag gcgaccatcc gggattcgtt
     6901 cagccggggc gcctcgacct gggtcagccg gtccgcgcgg ctccccgcca gggcctcccc
     6961 ctgccacagt gccagcgccg cccgcagccg cgccgacgca gtggcgtcgt ccccgcgctc
     7021 cgacgcctcg gccgcaccac gggtcagcag ctcgaactcc cgtagatcca gcactccgtg
     7081 gtccagccgg agcacgtacc cgccgggctg ggtcgccagt acctcaccgt cggcgcggca
     7141 accgtgcagg gcgtggcgca gccgcttgac gtagttctgc agtgtggtgc gggccgtcga
     7201 ggggggctcg ccgccccaga tcccgtcgat cagctcctcg gccggaaccg gacggtcggc
     7261 gttcagcagg agcagggcga gcagatcgcg ctccttcgga gccgtgatcg ctatggactc
     7321 gcccgcgcgc cggacgtcca acggccccag gacccgatag tggaacaacc cgcacccctc
     7381 ccccaacgcc cgaacgggcg ttggggggag cctacgggaa cgcctcgctc aagcctcgct
     7441 agtaatccgc tagtaccgcc ctcgcatgct gacgccacgt tgaccgcgct acaccggagt
     7501 tgcattcatg accaagtctg cgcccgatca gaacaatctt cgtgtcgccc tcgtggaacg
     7561 ccatccgctg ctgcgggcgg gcatccgttc ggcactcgac agcgcggggg gcatcgaggt
     7621 cgtcgcggag gccggggagt tcgaccacgt ggtgcccctg gtactgagcg ccgctcccga
     7681 tgtggtgttg atggatctgg atctgcccgg ttccgcctct gtggaggtgt gcagaacgct
     7741 ggtccgcgat gccggggtga gggggatcct gggcatgacg ggccacgggg acgacgagag
     7801 gctgctgcgg gcggccctga tggccggggt ccgcgggtac gtgtcgaagt cggcgggggc
     7861 cgccgagatg atcggcgcgg tgcacatggt gggcaacggg ttcatggtcg ccagcgacag
     7921 cgcggcccgg ctggtcacag gcctgttgtg ggcgcccggc cgggccgcgg agcacgatcc
     7981 gctgccgatg ctgacccggc gcgagcggga gatcctggac ctcgtggccc gggggtacga
     8041 caaccgccgg atcgcccgtg ccctgaccct ggccgagaag accgtacgca accacgtctc
     8101 ggccgtcttc gcgaagatcg gcgtcaactg ccgggcgcag gcggtggtgt acgggcgtga
     8161 ggcgggcatg ggcctgacgg cctgaggtcc gttgcggggg gcgggcgggg ccgggcgggc
     8221 cggggggggc ggcctggtca gtggtacccg gcggcctgga ggtcgaacag ggaggcgtac
     8281 aggccgtcgg cggccatcag ctcgtcgtgc gagccctctt cgaggacccg gccgccgtcc
     8341 agcaccacga tgtggtcggc ggtacggacg gcggagaagc ggtgcgccac cagcagcgag
     8401 gtggcccggg tgtggacgct gcgcagtacg tcgaacacct ccgcttccgc ggcggcgtcg
     8461 atggctgccg tgggctcgtc gaggatcatg atcggagccc tgcggaccac cgcccgggcc
     8521 agggccacct tctgccactg gccgccggag agctggtgcc cgccggggaa ccagcggccg
     8581 agctgggcgt cgagtccgcg cgggagcccg gccaggatgt cgcgggcgcc ggccgtctcg
     8641 gcggcttccc acagcagctg gtcgtcgtcc agggcggaca ccctgccgaa gccgatgttc
     8701 tcccggaccg gcgcctcgta ctgctggtag tcctggaaga tcaccccgat gctgtcccgg
     8761 agctcgctca gcgcgtagtg cgtgaggggc ctgccgtcga gcaggatccg gccgccggtc
     8821 ggctcgtaga accgggtgag gagcttgagc agggtcgact tgcccgcgcc gttccttccg
     8881 acgagtgcca cgcacgctcc cgccggcacc gtgaaggaca cgccgtcgag taccgcccgc
     8941 tcgtcccccg ggtaacggaa tgagacgttc tggaactcga tcccccgtcg cagcacggtc
     9001 ggtacgggca gtccgtccgg ctcggacggc tcctccgcca tgtccaggaa ggcgaacagg
     9061 tggctcagga agaggcagtt ctcgtagagc tgcacgccgc tcgcgaacag gccccgcacc
     9121 gaggcctgga tcagcgtgac gcccgcgatg tatccggcga ggacgcccac ctggccggtg
     9181 cccagcgccg aacgcacggc cagcaggatc gccactgcgg tcgtccccgc gctgagcagg
     9241 ccgaacagcg cgctgaacag ggccctgcgg tgctcgatgc gccggtcggt cgcgtggaac
     9301 tcgtccacca gcgtccgcga ccgtccgagc agcagcggca ccaggccgaa cagccgggtc
     9361 tccttgtagg tctggtcgtt ggtgagcagg tgctccaggt aggtgagccg ccggcgtccc
     9421 tccgaccggg cgtgctccac cgcgtgggta cgccggctga agtacaggct caccagcgcg
     9481 gcgggcaccg gggcgaggca gatggccagg gccaccggca cgctcgtccc cagcagaacc
     9541 gctccgaccg acaggaagga caccgccgcg gagcccaccg cgatcaggtg cgtgaagacc
     9601 tggaggggcc ggaacgcgga ctcccgggtg gcgcgttgca ggcggtcgta cgtatccggg
     9661 tcctcgaact ggcgcaggga cagccgggcc gacttctcca tgaccgacag cccgaccgcc
     9721 tccggcagcc ggctgcgcag cagggcctgc tggtggtcct ggaacaccgc gaggaagtgg
     9781 ctcaccacgg ccacacccgc cagacacccg cccgccgtga gcgccggtgc ggttcccgtc
     9841 ccccggctca ccgcgtccac cacggcctgg accatccgcg cggtgaagta cacctggacc
     9901 gcggggagga gcgccgagac cagggagatc acggacaccg acagcacctg gcgggggctg
     9961 atcccccaca gcaggcgcag ggcccgcacc ccgagccggc tcaccgccgc ccgcccgccg
    10021 cgcgacggcc ctggacggcg cgcagcgcga gcgcccgcag atgcccgcac cggacctcgc
    10081 gctcccggtc gaggccctga agccggatgg actgcatgtg ggcgaggctc ccgaggatct
    10141 cgcgctccgt gccgatcagc tgcccggact cggcgaggct ccgcacgagc cgtcccgcgt
    10201 ccgccaccac gtccgcctgc accgcgagca ccgtgcccag cgcgtccgcc cactcgcgtg
    10261 cgagcgggtc cgggcgttcg tcccacggcg cgatcaggtc gcacagcgtg cggcgcacgg
    10321 tgcggaaccg ttcacgggtg gccgacggga tctccttccc ggcgaggccg tggcctccgt
    10381 cgggggcggc gccccactgc cggtggagcg cgtccagtgc gtacgcgccg acgatgtcgg
    10441 cgtccaggcc gggacggctg cggagcaggc ccagcagcgc ggtcgccatg tcgctgcccg
    10501 cttcgaagac cgcctcggcg gcgtccatca cgagcggacc cccgtaccgc tcggtctccc
    10561 ggtcgtagga gacgaccgcc aggtccgcgg ccagccccgc gtcgaccagc cccttcgccc
    10621 agccgacgag ccggaccagc ggcgccgagg cgtcggcccc gggtgcccgc ctcacgcgta
    10681 tccgcaggtg cgggtggggg tcgccgtagc ggatgaagaa ccaccggtcg atcaggccct
    10741 cctcgcgcag cccccggatg agttccggaa ggctgccgct gaggatgtcc tcgtgccggg
    10801 cggctgccgc gtagagcttc acgtgggccc agtcgccgcc ggcggtctgg cgcttggcac
    10861 gggcggggtc ggcggccagt tcgcgggcgg ccagggccgc ggccggggag acgaccggga
    10921 ccggcgtttc caccgccgtc ttcctggcca gcagggggac gacgatctcg ttcgcgtacg
    10981 agcggccgtc cgcgtcgcgc agccaggacg gctgcgcggg atcggcgacc gactcctcga
    11041 gcaccagggc gccggggcca ccgggtccgt aggaggtacg cagggcgcgc tggagctcgt
    11101 ccacgcacag cgggttctcc aggtcgagga ggatccggtg gtcgaacagg ctcaggtgga
    11161 cccagcgggg cacctgccag gcctgccgcc attgcccgaa cgcgtcgaag aaggcctcgc
    11221 ggtccatggc cgcggcgtcg gcgcagccgt cggggaatcc cgggacgtcg gagccgaaca
    11281 gccagcgtgc gggcttgagt acgatccgcc ccctggtcac gcgcggcagg aacggcgccc
    11341 gctccatggc gccccaggag aactcggcga gtggggccca gccgtcctcc gaagcctcca
    11401 gcaggaaccg gcacacgttg ggcgcgctgc cccagttgac gaggtggctc tgggtcacgt
    11461 gcagttgcct gtcgaggcga gccgaccgca ggtagaagcg gtcgggagtc gcccccacca
    11521 gtacatcgga gaggtctatc tgctgtacgt cgcctcctgt gggcgaggcg ttgacgcaga
    11581 tctcgtagcg gcgaaccggc gggtgaacgg cgacgtttcc tcgccgcccc tccagctggg
    11641 cgtagttgag ctcggcgaag accgtggcgg tgcagagctc ctcctcggcc gtggcgtact
    11701 cctgtagcag cttctggaag ttctcgccga gcaggtcgaa gaaccgcccc ccgaagcggc
    11761 cgccgtcccg catggggccc gtgctgagca cgaacttcca gtctccgtcg tccagttgtc
    11821 cccgcgatcc cgcgacgacc tgccccatga tgtccagcga cggccgggcg tccgggcccg
    11881 agcccccgtc gtcccgaggc tgccacgcct tgagaaaggc atccgtgatc tccacttcac
    11941 gcttcccttg gtggagcgct gcggcagcga gggcggccag tgcctcctcc tgctcccgcc
    12001 ggtccttcct cggggaagga gtcaggggca gttcgcgggg cggatacctg tacgtctcgg
    12061 gtgcgtcaag gccggtctcg ggattcagca ggtccaggac ggggacctcc gcccccacgc
    12121 catagcgctc gaggaattcc ctgtggtaca cggcgagatg gtgcagccgg ggtgtctgct
    12181 gccccagtcg cagcagcacg tcggcagcct cggcggcggc gtcggccacc tgcgagtgga
    12241 gggtggtgcc cctcaggtcg agccgtgcgt ccgcgtggaa cgggctttgt gtgtggccgg
    12301 gcaccaccac ccgctggtgg tcgtacagct ccgccagcag tcggctgcct tcctcgggcg
    12361 gggcctggtc cgctgccgcg gcgagctgcc gggtgcggcg cagggcccgg cggtagcggc
    12421 cggcgccggc gaggccttcg atgcggtcga ggaccgcctg ctcgggacag gggtgggtca
    12481 gggcggggcg gaggtcactc gtcagcatgc ccaggtccca caactggtcc atcagggccg
    12541 tgatcttcgc cggcggcgcc gccgggaact cccccgccag cgcggcgatc agctctgacc
    12601 agcgcggccg ggcggcggct cgggccagga cggcatcgac ggcccgggtg gcgcggacgc
    12661 tgctcgactg ctggtccgcc gtgaccgatg tctgagccac ggccagcgtg atgcggtcgc
    12721 cggtgcgctg gagcagcggg ttcactccga ccgtcagctc gccccgcagc tccggatcgc
    12781 cctccatctc cttgaccagt gccatgagcc accccatgtc cgcgcgggtc ctgccggccg
    12841 ccgggtgttc accggtccgc gccagcgtgg tggcttcgcc gaactccccc gcctccacct
    12901 gcgcgaacag accgtacggg gtgggccggg agctcattcg ggacaggtag cgcagcagtg
    12961 aggaatgcat ccggtcggcg gcgcggctgt cggccccggg cgcgctcttc tccagctcct
    13021 ccgcaaggct gtggctggcc acgcgcacgg cctgtcggac caggggctgc tcccccagcg
    13081 tccaaaggtg atcgcgggca ccccggcccc ggccgtcgag tgcctcgacg tacgggtcga
    13141 ccggcagcgc cggcgagcgg accaggaaga atccggcagg ggtgtacaga ctcatggggt
    13201 cactttcttc cgcaggtggg tcaggcgatg agcagggcgc gttgccaccg ccgtcggggg
    13261 gcgggcgcgg acacggtcca cagcactgcg gcaacaccgg ctgctccgca caggaagtcc
    13321 gggttgtcga tccgcaggtc gggcctttcg aggttctgca ccccgaaggc caggtcctcg
    13381 gagcagtgcg cgagcagccg ctccgtcagt acggggagcg cggccctggc ctggacgctg
    13441 tccgtcgtac gggcgaagac ctcacagatc gccagcaggc ccgccaggcc gtggcagatc
    13501 gtgggcgaca gggtgtggat gtgctcttcg gaccgtcgca gcgccgcttc gaacgccgcg
    13561 acggcgtagg cccgcagttc ctcgtcctcc agggcgtcgg ccgcgatgag cagggcggcg
    13621 gcgatccccg gcgctccgta gcaccaggct gtcctggcgg ggtgccgggc ctgggtgcgc
    13681 ctgccttcgg ggtccatcgc tatgccgctc ggccagtcga tcccgaagcc gtcctcgacg
    13741 gcggcggacg acagcagggc gatcccgttg ccgatcgcct cgcgcaggcc ggggcggcgg
    13801 tagccggctc gccaggccag ggacagcgcg gcgagcgggc cggggatgcc gtgggcgagg
    13861 cccaggttga tgtacccgtg cggatactcc tccaggtccc tgggaagcag cgggtagtcc
    13921 tcgggcggga cgacccagcg ggactccgcc tccgccgggg cgggggtgca gagccgcacc
    13981 agctcgtcga cgagtccgtg gacgccgtcc cgcagtgcgg catccggtcc gggcacggac
    14041 agcaagtagc cgagggtgcc cgccgctccc tgtagcgcgt cgtactcggc gatgctcgca
    14101 tgggagccga cagccggctt gtcccgagcg cccagctggt cggcgaggcg ggtgtgcagg
    14161 ctgtcgagcg gtcgctggta gcgctggtcg cccgcggcga actccgaaag tgcgagggcc
    14221 aggccggccg acccgccgac gatgccatgg ccgaacagcg gcctgtcgtg ggtgctccgc
    14281 accgctcggg tcagcgtccc gtgtgcggcc cggcgccagt ggtcaccgga ttccgggtcg
    14341 gcctccgagg ccaggcgcag caccatcgcg atcccggcgt caccggcgag cagcgagctg
    14401 gcgcgccgcg ctcccgaagt gttggggtct gcggtcgacg cggccacgcg gtcggcgacg
    14461 tacccggcat cggcgaggcg cgaggcgatc aggtgtgcgg tgcggcgtgc ctgcccggcg
    14521 agggggccgg tgatcactgt ccggcctccc gcgcgtagcc gaagctgtcg aggaggtggc
    14581 cgaacctggc ctcgaaccgc tccacgtgcg cgggggagaa ggactcccgc cagcgtccgg
    14641 tacggccctt gttgagcgtg aaggactgcg ggttgaagag gcggtcgacg acggactcgg
    14701 ggtcgacgtc gtggtccagc cagtccgcga cgcgccccac cgcggccagc tgcgccgcgc
    14761 ggctcccgcc gccctgcggg ccgacgagat cctcgaagga gacgtggcag acgttcgggt
    14821 ggtgcagaaa gctgatggcg gactcgaagt cggacagcag cggcatctgc ggatcggaca
    14881 gcgcgtagtc cagcttcttc ccgtagtcct cgatcgactc caggaccgga ccgaagatgg
    14941 ccgactccgg gtacctcatg aacttgagcc cgttgttccg ggagaagaag tccacgagcg
    15001 agacgaggac gtccctgggg tcccggtagt tcaggatcac cttgggggag ccggtgttca
    15061 cccactcggc caggaacgag ctgtccatcc gccagacgtc caccgagtgg aagatccagc
    15121 tcacaccggc cggggtactg gaaaacggag cggtccagat ctcggggcgc atcttcgggc
    15181 cgaagcgtgc ctccggagcc atcgcctcga catgggccag cggcgccacg gccaggcggg
    15241 tctgccacgc ccaggccagc tggagccaga cctcgtccgt ggtacggatg aaggcgtccc
    15301 ggtcccgctc gtggtcgagt gcttcgaatt cggcggggtc gaggaacttc tccgccatct
    15361 cgagccgctc gcggatactg aaggccgggc gccccgcgct cggcggtacc ggctcaccgt
    15421 agatcctgta gccgaggtgc acgagcagtt cctgcaccag gtgggttccg cttttccgcg
    15481 gagatatgac gaagacccgc tcgcttgaca cttcaggccg ccctttcaca tgagtacggc
    15541 ggcctgccct gaaagggcag gccgcctccc gatcattgtc agcagacagc gcaggtaatg
    15601 agcgttgcct cctggtcgca gcagtacgag gcacacgtgc ccttgcacga gtaccagttg
    15661 ctgaacccgc cctcgatgga cgggatgtcc gagctcaccg cgatgcgcac atcgaggtcg
    15721 aagtcatcga ggccgtggtc ctggacgacg ggctccacca aagaaaccga catgttttct
    15781 cccatgagtt gattggggcc gaatggaacg agatgatttt ctctcgccat ccgtcccgga
    15841 ttcctgatgc aaatgtcccg accgtgtccc gattcagcaa aaacagtggg agtacataat
    15901 gggctgcgaa acgcattgca tgccacacgt gcccttgcag gagtaccagt tgctgaagcc
    15961 ggcctcgatg ggcgccatgt ccgaactcac cgcgatgcgc acatcgagat cgaactcatc
    16021 gaggccgaac tcccggacga ccggatctac cagagaaact gacacgtttc cccctcgcaa
    16081 ttggggccga atgaatcgag acgatcatct cccggattcc gtcccggata cctgatccag
    16141 atgtcccgac tgcgtcccgg cttttctcac cgcacgagcc cggccgccgt caattcggaa
    16201 aggcaggcgt cgacctgggt gcgcgcggac tcggaatcca gtcctgccct gcgcccgtat
    16261 tcatcccgta cggatcccac gtctcggccg tcgcacagcg aatagatcag ccatgagcgt
    16321 gcgttgagcc agtgcatcgc ggcggtgtcc gtgttcacca cgagcagttc cccccgctcg
    16381 ggcagcggcc gggccatcgc gcacgtggta cggcgtacca ccacgccctc cggcacggcg
    16441 ggcggctgcg ccggggccac gcctgccacc cccgtgggcg gcgtgatccc ggagtcctcg
    16501 tgcaccaggt gcagcgcgtc gagcagccag ctcaggaacc gccggccgtc ggccgtcagg
    16561 cgcccttccg gcaggccgag ggcgtactcg gccaggtagc gggcgcgctc caggctcgac
    16621 ccgtaggtgc cgttccgggc cgcctccgtg tccgggctca ccgcgtcgat gacctccccc
    16681 gacggcggat cgccgaactg cgcccggagc gtgtcgtccg cgtgccgggc ggcctcctgg
    16741 aacaccagca tgtggacgta gaagtggagc gcgacgagca cccgtacgag ccgccattgc
    16801 gtctgccgcc acgggatcgg caccgacagg tccgcgtcct tcagcagcgc gcccgagcgc
    16861 agcgcgtcga agagcttgag gtggacgccc tcgtgcagga gggtctcggc ggccgtccac
    16921 gggtcgtcga ggcgctccgg ggccatcagg atggccgacg ggagggggtc accgcccgag
    16981 agcgactgca gcgggccgtc ggccgactcc ccccgggtga agccgacgac ggagacgtgc
    17041 cgcagcacgc tggggccgac ctgcggcagc agccgcgtga gcaggtcggc tccccgggtc
    17101 agcgctcggc acatctccgg ggtcggtatg acgggatccg cggccggacc gccttcgatg
    17161 ctgccgtcgt agagccggcg cagccgggcc gacaggtccc ccggcacccg gtcggccggg
    17221 ctcatctcgg tccacagcca ggcgggcccg tgctccggcc acggcctgac gtgcggggtg
    17281 gccatccgct cgcacggccc caggccgtcc gggtcgagcg gcaggcgggc ggccagttcg
    17341 gcgaggccga gggcgccgga atggccgttc tccagcttgg ccatgtcgtc ctcgaagacg
    17401 ttgcgcagga ccgggtcgcc gagcagcggt agcagctgct cgcggctcag cagcgagagc
    17461 cgccgcaacg cgtccgggtg gcgggcgtcc ttctgcgcca gcagctggag gccgaggacg
    17521 aagcgggcca cgttgcgttc tccgatggcc ccggaatcac cgaatcggcc atcggcgacc
    17581 agcagtccgt ccgcgcggcc gattttctct cgggaggaat cacgtgatgc tacaagcgac
    17641 atcgaaaaca ccgtccggta cggagtgcgg gaaaaaggga accggggggt gcccggaact
    17701 ggcacccccc ggctgaatgt cacgcctcag gcggcggcgg gaccggccca gtaggcggga
    17761 acccaggcgc gctcctcgcc ggaatcccgc ccgatctgcg ggacgctctc ggctgccagc
    17821 cagttctgcg cgatggccgg gaattcgatc tccaactgcg gcatcagctt ctcctctcgt
    17881 ccactccctc tggaatggac ttcgtcagga tgtccgaatc cggtcccgac cttcatgagg
    17941 cggctgtccc gtacttgtcc cgataccggg aagaaatccc gggagcaggg gaagcggacg
    18001 cgaaaaagcc cggccccgca cggaatccgt gcggggccgg gctttgaacc gcttacgcgg
    18061 ctgtgactac ttgccggact tggcgcgcga cgcggtgcgc gagcggtcct tctggtccag
    18121 gacgaccttg cggatgcgga cggcctccgg ggtcacctcg acgcactcgt cgtcgcggca
    18181 gaactccagg gactgctcca gggagagctt gcggggcggc accacgttct cggtgttgtc
    18241 cgcggaagcc gcacgcatgt tggtgagctt cttctccttg gtgatgttca cgtccatgtc
    18301 gtcggcgcgc gagttctcgc cgacgatcat gccctcgtac acctcggtgc cgggctcggt
    18361 gaacaggacg ccgcgctcct gcaggttgat catcgcgaac ggcgtgaccg aaccggagcg
    18421 gtcggcgacc agcgaaccgt tgttacgggt caccagcggg ccgaaccacg gctccaggcc
    18481 ctcgtggatc gagtgggcga tgcccgtgcc gcgcgtaccg gtcaggaact cggtacggaa
    18541 gccgatgagg ccgcgcgacg ggacgacgaa ctccatgcgg acccagccgg agccgtggtt
    18601 cgacatgttg tccatgcggc ccttgcggac gcccatgagc tgcgtgaccg cgcccatgtg
    18661 ctcctcgggg acgtcgaccg tcatgcgctc gaccggctcg tgcaccttgc cgttgatctc
    18721 ctgcgtgacc acctgcggct tgccgatggt cagctcgaag ccctcgcggc gcatctgctc
    18781 gaccaggatg gcgagcgcga gctcaccgcg gccctggacc tcccaggcgt cgggacgctc
    18841 ggtgtcgagg acgcggagcg agacgttacc gaccagctca cggtccagac ggtccttgac
    18901 ctggcgggcg gtgaccttgc ggtccttgac cgcggacttg gcgtccgcgc ccttgccgct
    18961 gccgccgcgg ccgaccatcg gggaggtgtt cgtaccgatg gtcatggaga tcgccggctc
    19021 gtccaccgag atcagcggca gggcgatcgg gttctccggg tcggccaggg tctcgccgat
    19081 catgatgtcg gggaaaccgg cgaccgcgca gatgtcaccc gggcccgcca cctcggccgg
    19141 cttgcgggtg agcgcctcgg tcatcatcag ctcggtgatg cgaacgttgg agatcgtgcc
    19201 gtcacgcttg atccacgcga cggtctgacc cttgcgcagc tcgccctgct cgacgcggac
    19261 gagcgcgatg cggccgagga agttgtcggc gtccaggttg gtgacgtggg cctggagggg
    19321 cgcctcgtcg tcgtacaccg gggccgggac gtgctcgagg atcgtggaga agaacggctc
    19381 gaggttggtg ctgtccgccg ggacggtgcc gtcctcgggc ttggtcagcg aggccacgcc
    19441 gtcacggccg caggcgtaga cgatcgggaa ctcgatctgg tcctcgtccg cgtccaggtc
    19501 caggaagagg tcgtacgtct cgttgacgac ctcgtcgatc cgggagtccg ggcggtcggt
    19561 cttgttgatg cagaggatga ccggcatctt cgcctgcaga gccttgcgca ggacgaagcg
    19621 ggtctggggc agcggaccct ccgaggcgtc caccagcaga acgacggcgt ccaccatcga
    19681 cagaccgcgc tcgacctcac caccgaagtc ggcgtggccg ggggtgtcga tgatgttgat
    19741 cgtgatcggg gccccgccgt ccttggggtg atacttcacc gccgtgttct tggcgaggat
    19801 cgtgatgccc ttctcacgct ccaggtcgtt cgagtccatc atgcggtcgt cgaggtgctg
    19861 gtgggcggcg aaggcaccgg cctgcttgag catggcatcg acgatggtcg tcttgccatg
    19921 gtcgacgtgg gcgacgatgg cgacgttacg gatgtcgtgg cgcgtgggca cttcggcgct
    19981 tctcccggga tcgtggatgg cgtcgcgtac ggcctggcac gcgcgcctcg accgggcgaa
    20041 aacctgccac ggccttaccc catggtacgt cgcgcggcgg gaaccgcccg ccggggggtc
    20101 tgtcaagagg ccggacgaat gaggacggcc gggtgcgggg tggggtgcac cggccgttgg
    20161 tcctgccgga aatcatgcgg gtcaacgggt atccacgacc ttgcccgccg gggatccggc
    20221 gggcaaggga cttgagtcac atctgagctt ggaagccaag ggtcaacctg acaggccccc
    20281 ctttgtcacc acttcttcgc ccactctcct tctgcggcta ctgcttcttg ttcttggccg
    20341 tcgggggctt cttccagccg atgtcctgga agcggggagc cccgagtccg aaggcgccgg
    20401 cgttggccag ggccggcttg acggccacca gctccgggcg ctggtagagg gggaccgagc
    20461 cggcagcggc ccagatcctg gcgtccgcct tgcgcatcag ctcacgggac tgctcctcgt
    20521 ccagctcgcc ggccgcctgg tcgaagagct ggtcgatgtg gtcggtgccg acccgtgtgt
    20581 agttctgttc gacgaggagc gagccgtccg cggccggctc cggcttggcg aagatcggcc
    20641 gggcgtcggt ggccgggtag gcggtcgcgg gccaggagta gagcgccagg tcgtactggc
    20701 ccgaggcgat gtggtccttg aagaagctct cgtcggccac cttcttgatc tcggtgttca
    20761 ccccgacctt ccggagcatc tgggcgatcc gctcgccgac cgagcgcagg gcctccgatc
    20821 cgggacccgc cgggagcacg aagcgcaggt tgagcgcctt gccgtccttg gcgagcatgg
    20881 cgccggaggt acgggtggcc tgcttggccg ggggcgcggt gcccttggcg ggatcggccg
    20941 gctcggctgc ctcgccgtcc ttgccgtcct tgccgtcgtc gacgctgccc gccgcggcgg
    21001 cctgggcacg gaggaaggcc tcctgccggg ccgcgaacgg cgccggggcg agcaccgggg
    21061 agggccggtt ccgggccgcg ccgggggcgt ccggggcgaa gacgtcggca tcgacgatct
    21121 cgccgtcggg gccgtactgc gccccctcgg ggagggcgcc gtgcgtaccg ccgtggtcgc
    21181 cgttgcgctc gtcgtcctgg cccacgatgt agaggccgtc gttgccggtc cccgggcccg
    21241 agggggtctt cgagtcgtcc tgcggcgcgc tctccggtcc cgccttcgcg cccgccggtt
    21301 cggtgatctt gccgccgcgg cgccagcccg cgtccgcgag cagggcctgg gccgcctggg
    21361 tgtcctggcc gccgagggcg tcgctgttgt cggcgtacgc gcgctgcccg gccagtgcca
    21421 ggtggctgcc gaccggcttc gcgggcaggc cgagcggctt cagtacgatc tcggccagtt
    21481 ccttgcggtt cagggcccgc gccaccgccc ggcggacccg ctcgtcggcc agcggaccgg
    21541 tggcgccgtt catggcgagc tgggtgtagg cgggctccag ggacttgcgg atggtgaacc
    21601 tccgcagggc ctcctgctcg gcggcgtacc gcgtgaccga ctcggcgtgc ttcttgcggg
    21661 tctccttctc cgcctccgcc ttctcctcgt ccgcgccgaa ggcgaccgcc caggacatgg
    21721 tggcctgcgc ggcggtcatg gaggctgcgg ggccgtgggc cggggccccg cccgcacccg
    21781 ccccgccggc acccgcgccg ccctgcttcg cgtcccggtg ggcgagcgcg atccggtcgg
    21841 cgccggagcg gtcgatctcc gccagatcca gcttcccggc ggccagcgcg gccgggcgct
    21901 ccgcccgggg caccgccgtc agcaccaggg tgtccagctt ggccggctgg ccccaccagc
    21961 gcggattgcg ggtcagggcg gcggtgccgg tcttcttgtc gatcgttccc aggccgaagg
    22021 gtccggcggt caccttgagg gcgcctcggg ccccttcgtt gaaggcgtcc ggggtggcgg
    22081 tgacctgctt ggggtaaagg gggctgaaca gggagcgcca gtcggcgtac ggcttggcga
    22141 aggtgacctt cacctccagg tcggtcttgc cgcgctcgat cttctcgatc cgttcgtagc
    22201 cggcgttgcg ggccgtccag aaggccgagt ccttgccgtt cagggcccgc cactgcgcga
    22261 cgaagtcggg ggcgccgatc tcgcggccgt cgctccacac cgcctgctgg ttcagcttgt
    22321 acaggacgac ctgcttgggc tcccgctcga cgacctcggc cttctccagg tagtcgggat
    22381 tggccaccgg ccgccccttg gcgtccagca cgaacagctg cggcagcacg gccgcggcga
    22441 tccggttggt ggtggcgtcc gcgtcggcct ggaaggtgtt cagggtctcc ggaagggcgt
    22501 ccaccgccca gcgcagcacg cccccgtcgg cgaccttgtc acgcgcggtc gtcgcgatgt
    22561 ccggtccggc ggcggccggg ccgccctcgt cgtcacccgc gccgcagccc gtgaggagcg
    22621 gcagtgcgag gactcccgag gtcaggagcg ccaaggacct gcgccttctc tgggacatgg
    22681 gtggtacctc cggggcgggg cgtgggggaa gcatgatcac gttcggcggt atatggagct
    22741 gatcacaccg gttgccggaa cccactgaaa tcgacagccc gccacacccc tcgcagccgc
    22801 ctcgcgccac gccgcgaacc ccacccgtgc ggaccaatcc cgcttgcgcg ccaaagaggc
    22861 gttccctcgg aagagggatg agaatggggt ccagggaggg gcgcacagtt cacgcctgcg
    22921 cgcccgcaat cgctgcacgt cccttcacaa cgggggacgt gaagggcgac actcgcaggc
    22981 gcacatgagc gttgccaccg caccctgcgg aagtgagggc acaaatcatg tccctgcaag
    23041 acgatctgaa tgccgtacgg cgcaacctgg acgagctgac gcgcaaggtc gagcagctgg
    23101 aacagcaggc caagcggaag gacccggcga gcccgcggac cggatccgcc ccgccggacc
    23161 cgtcccggat ggtgacggtc cccgacaccc cgtacgacag ctcgctgtgg acggacaccg
    23221 acgacgaggg tctgggcgcc cgcgaccgcc gcgccccctg acgtcccccg ccccgcgagc
    23281 acccgtacgc ccttcacccc atctggcccg gccgcccacg gcggccgggt ctcctgggcc
    23341 catcactcct cccggagtct cctttggcca caggcacaca accaccccag cagcggcccg
    23401 gcggcgtcca cgacgcctcc cgggccgcga tcgctgcccg gcacctgcgg accgaccggt
    23461 ggtggctggc ccccgccggc accgcggccg ggctgctcgc cttcatcgtc tactcgacct
    23521 ggcgggcgtt cgctaacgcc gactactacg cggccccgta cgtctccccg ttctactccc
    23581 cgtgtctcgc ggagaactgc caggagatgc gcggcggccc caactgggac ctcttcggca
    23641 gctggtgggt cctgtccccc gccctgctga tcctgatctt cccgctcggc ttccggctga
    23701 cctgctacta ctaccgcaag gcctactacc ggggcttctg ggcctcgccg cccgcctgcg
    23761 cggtcgccga accgcacgcg aagtacaccg gcgagacccg cttcccgctg atcttccaga
    23821 acgcgcaccg gtacttcttc tacacggcgc tgccggtcgc gggcatcctc acgtacgaca
    23881 ccgtgctgac gttccgcgac gagcactacg agtggggcca catgggcctg ggcacgctga
    23941 tcttcctcgt caacatcgtg ctgatctggg cctacaccgt gtcctgccac tcctgccggc
    24001 acatcatggg cggccgcctc aagcacttct cgaagcaccc ggtgcgctac cggctgtggg
    24061 gctgggtcag ccggctcaac acccgtcaca tgcagctggc gtgggcctcc ctggtcagcg
    24121 tggccctgtg cgacttctac gtgtacttgc tggccaccgg cgcgttcacc gacccgagga
    24181 tcttctgaga tggctcaagt ggaacggcag cagtgggacg tggtggtcgt gggcgcgggc
    24241 ggcgccgggc tgcgggccgc gatcgaggcc cgcgagcgcg gcgcccgtac ggccgtgatc
    24301 tgcaagtccc tcttcggcaa ggcccacacg gtgatggcgg agggcgggat cgccgcctcc
    24361 atgggcaacg tcaacgaggg cgacaactgg caggtgcact tccgcgacac catgcgcggg
    24421 ggcaagttcc tcaaccagtg gcggatggcc gagctgcacg cgaaggaggc cccggaccgg
    24481 gtctgggagc tggagacctg gggcgcgctc ttcgaccgca cgccggacgg gaagatc
//
