LOCUS       NZ_CP102509            21074 bp    DNA     linear   CON 06-JAN-2024
DEFINITION  Streptomyces sp. NBC_00162 chromosome, complete genome.
ACCESSION   NZ_CP102509
VERSION     NZ_CP102509.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NBC_00162
  ORGANISM  Streptomyces sp. NBC_00162
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8635149)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Joergensen,T.S., Klitgaard,A.,
            Mourched,A.-S., Blin,K., Larsen,T.O., Weber,T., Gotfredsen,C.H. and
            Charusanti,P.
  TITLE     Identification of the biosynthetic gene cluster for pyracrimycin A
            and elucidation of a key reaction during its biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8635149)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/05/2024 18:03:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,275
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,805
            CDSs (with protein)               :: 7,805
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 371
            CDSs (without protein)            :: 370
            Pseudo Genes (ambiguous residues) :: 0 of 371
            Pseudo Genes (frameshifted)       :: 186 of 371
            Pseudo Genes (incomplete)         :: 231 of 371
            Pseudo Genes (internal stop)      :: 27 of 371
            Pseudo Genes (multiple problems)  :: 68 of 371
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:41:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3327310
            Orig. end                         :: 3348384
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21074
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="24"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11074](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11074)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    182..197
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.96"
                     /tool="antismash"
     misc_feature    complement(548..561)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.54"
                     /tool="antismash"
     misc_feature    563..576
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    complement(565..578)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.29"
                     /tool="antismash"
     gene            822..2024
                     /locus_tag="JIW86_RS15205"
                     /old_locus_tag="JIW86_15205"
     CDS             822..2024
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266483.1"
                     /locus_tag="JIW86_RS15205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15205"
                     /product="NADP-dependent malic enzyme"
                     /protein_id="WP_257554235.1"
                     /transl_table=11
                     /translation="MAAEIVNPHTDSATDNNPDAVFALHRGGKMAIQATVPVNNKDDLS
                     LAYTPGVAKVCSAIAEQPDLVNEYTWKSNVVAVVTDGTAVLGLGDIGPEASLPVMEGKA
                     ILFKQFGGVDAVPIALATKDTDEIIETVIRLAPSFGGVNLEDISAPRCFEIERRLQEAL
                     DIPIFHDDQHGTAIVTLAALRNAAKLTGRTLGDLRAVISGAGAAGIAIAKILVDAGIGD
                     VCVTDRKGVVSADRSDLTDVKAEIAGLTNKTGQTGSLEKALAGADVFIGVSGGTVPEAA
                     VASMAKDAFVFAMANPNPEVHPDVAHKYAAVVATGRSDFPNQINNVLAFPGIFAGALKV
                     RATRITEGMKIAAADAIAGVVGDELAADYVIPSPFDPRVAEAVSSAVAAAAKADGVARL
                     A"
     gene            2180..3142
                     /locus_tag="JIW86_RS15210"
                     /old_locus_tag="JIW86_15210"
     CDS             2180..3142
                     /NRPS_PKS="Domain: PKS_ER (16-318). E-value: 1.5e-34.
                     Score: 111.4. Matches aSDomain:
                     nrpspksdomains_JIW86_RS15210_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966331.1"
                     /locus_tag="JIW86_RS15210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15210"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_257554236.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.4e-19, bitscore:
                     69.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAAYAARIDRDHPLNGLELGERPAPEARPGWVTVNVKAASLNHH
                     DLWSLRGVGLGQDKLPMILGCDAAGTDQDGNEVVLHSVIGQSGHGVGPDEPRSILTERY
                     QGTFAEQVTVPAWNVLRKPAGLSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAG
                     GGVATAAIVLGKAAGLRVFATSRDEAKRKRAVELGALEAYEPGARLPQRVDAVIETVGA
                     ATWSHSVKSLRPGGTLVISGATSGDRPEHAELTRIFFLELKVVGSTMGSKDELEDLLSF
                     CATTGVRPVIDEVLPLDRAREGFEKLASGDLFGKIVLTP"
     aSDomain        2228..3133
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS15210_PKS_ER.1"
                     /evalue="1.50E-34"
                     /label="JIW86_RS15210_PKS_ER.1"
                     /locus_tag="JIW86_RS15210"
                     /protein_end="318"
                     /protein_start="16"
                     /score="111.4"
                     /tool="antismash"
                     /translation="GLELGERPAPEARPGWVTVNVKAASLNHHDLWSLRGVGLGQDKLP
                     MILGCDAAGTDQDGNEVVLHSVIGQSGHGVGPDEPRSILTERYQGTFAEQVTVPAWNVL
                     RKPAGLSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGKAAGL
                     RVFATSRDEAKRKRAVELGALEAYEPGARLPQRVDAVIETVGAATWSHSVKSLRPGGTL
                     VISGATSGDRPEHAELTRIFFLELKVVGSTMGSKDELEDLLSFCATTGVRPVIDEVLPL
                     DRAREGFEKLASGDLFGKIVL"
     CDS_motif       2570..2608
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIW86_RS15210_0001"
                     /evalue="5.60E-04"
                     /label="PKSI-ER_m4"
                     /locus_tag="JIW86_RS15210"
                     /protein_end="143"
                     /protein_start="130"
                     /score="13.4"
                     /tool="antismash"
                     /translation="AACLPTAWLTAYR"
     CDS_motif       2639..2692
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIW86_RS15210_0002"
                     /evalue="5.90E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="JIW86_RS15210"
                     /protein_end="171"
                     /protein_start="153"
                     /score="15.7"
                     /tool="antismash"
                     /translation="GDSVLVQGAGGGVATAAI"
     gene            3204..3413
                     /locus_tag="JIW86_RS15215"
                     /old_locus_tag="JIW86_15215"
     CDS             3204..3413
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005312042.1"
                     /locus_tag="JIW86_RS15215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15215"
                     /product="HTH domain-containing protein"
                     /protein_id="WP_257554237.1"
                     /transl_table=11
                     /translation="MTEATDLAERAGDRDPRVGLRAVAALRRLLEQLEAVQVRSARTQG
                     WSWQEIAAELGVSRQAVHKKHGRL"
     gene            3413..3925
                     /locus_tag="JIW86_RS15220"
                     /old_locus_tag="JIW86_15220"
     CDS             3413..3925
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266479.1"
                     /locus_tag="JIW86_RS15220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15220"
                     /product="Clp protease N-terminal domain-containing
                     protein"
                     /protein_id="WP_257554238.1"
                     /transl_table=11
                     /translation="MFERFTTEARDTVTGAAAEARQAGSATVTEEHLLLALLSRGALDF
                     LGVDRAAVAADLAAARRRGGMSRADEEALAGLGIDLSEIVSRVEEAHGEGALSPAAPRR
                     RTRHVPFTQGAKKVLEQSLRIALGRKDRRIAAPHLLLALLSRPGTVAEVLTDHGVTYAT
                     AETGLAA"
     gene            complement(3926..4831)
                     /locus_tag="JIW86_RS15225"
                     /old_locus_tag="JIW86_15225"
     CDS             complement(3926..4831)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154110.1"
                     /locus_tag="JIW86_RS15225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15225"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257554239.1"
                     /transl_table=11
                     /translation="MPPVFAHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAG
                     TVYPRLAKLEAEGLVTHATEGGRKVYSITEAGRAELADRGGELADLELEIRDSVTELAA
                     EIRDDVRGAAGDLRREMRAAASASATRVDDESWKTIKEEMSKARQEWKEQARRAKDESR
                     RAREEAQQARRQAKEAQERAREEVQRIAGQLQEQFAKSGGVLGSLAGAWLGGGTTPTAP
                     TQPSAPADSAAPPVADTGWAEDLTPTGDPARDLDRLLDRFRDDVRDAARDHGVSAAQLA
                     EARAHLAAAASRLKAALNGA"
     gene            complement(4833..5774)
                     /locus_tag="JIW86_RS15230"
                     /old_locus_tag="JIW86_15230"
     CDS             complement(4833..5774)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741545.1"
                     /locus_tag="JIW86_RS15230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15230"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_251065075.1"
                     /transl_table=11
                     /translation="MAEQASQSTWHIAEAQKLTFEEPVTRLRVRLVSGTVNVIAAEEGP
                     ARLEVTEVDGPPLYVVQEGGTLTVSYEDLPWNGSQGFKKWWEAKPWKAWSSSASGRKAW
                     ERSAAVTLTVPATTHVEVAVVDATSFVSGISGGTEVNAVSGGATLSGLSGKVKAHTVSG
                     NVEAQSVTGDLGFHSVSGDLTVVDGAGVSVRGDSVSGDMLIDLDLDPSAPRPVDIAVNS
                     VSGQVAIRLPHPADARVEANTATGGVSNAFEDLRVSGQLGSKRITGTLGSGTGTLRATT
                     VSGAIALLRRPPADTDGTASAPTPLALDKKVL"
     gene            5924..6154
                     /locus_tag="JIW86_RS15235"
                     /old_locus_tag="JIW86_15235"
     CDS             5924..6154
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS15235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_15235"
                     /product="hypothetical protein"
                     /protein_id="WP_257559644.1"
                     /transl_table=11
                     /translation="MWACRSPASGFRCAAAYEWDERGRPDGEPDGLTPGEPADRLRESV
                     RRRSPGWAAAGAVLTAQGAPSLAYDHARRSR"
     gene            complement(6482..7417)
                     /locus_tag="JIW86_RS15240"
                     /old_locus_tag="JIW86_15240"
     CDS             complement(6482..7417)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889347.1"
                     /locus_tag="JIW86_RS15240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15240"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_215146804.1"
                     /transl_table=11
                     /translation="MELEVRHLRALCAIADAGSLHKAARHLGVSQPSLTTQLRRIERAL
                     DGELFLRDRTGCRPTPFGRTVLGRARPLLAEMAALVAEARALAHGPRLRIGSTASRALP
                     GWLRRIHRRLPDTETSLVVDVSANALLRMVASGQLDVAFVHEVEGSPLRVPAGLQLHVL
                     MEREPQFVSMSRDHPAAGQAVVSLRDLADDRWMVDPSVDGEWDGLRRVFAGAGLDPPVL
                     HADYHTASSLIVSGEAVAPCQPTSGPREDMAIRPLSGDPLAVRLLLATRPGAHAEVYED
                     LRAAYREAALRTPPYRAWLHHHASPLLEAA"
     misc_feature    complement(6857..6859)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7627..8283
                     /gene="snpA"
                     /locus_tag="JIW86_RS15245"
                     /old_locus_tag="JIW86_15245"
     CDS             7627..8283
                     /EC_number="3.4.24.77"
                     /codon_start=1
                     /gene="snpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266475.1"
                     /locus_tag="JIW86_RS15245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15245"
                     /product="snapalysin"
                     /protein_id="WP_257554240.1"
                     /transl_table=11
                     /translation="MRHSRKAVLATTIGLGLAAALGVVPTATAATAPAGTPASYAAYDN
                     SQENQAANKAFFEAVQRSVAEQRAANPGILAVTVTYNTRNAPSFRTQIARSTQIWNSSV
                     TNVKLQEVSSGGNFSYREGNDSRGSYASTDGHGRGYIFLDYRQNQQYNSTRVTSHETGH
                     VLGLPDHYSGPCSELMSGGGPGTSCQNATPNSTERARVNQLWANGLVASGLDTKG"
     gene            complement(8568..9149)
                     /locus_tag="JIW86_RS15250"
                     /old_locus_tag="JIW86_15250"
     CDS             complement(8568..9149)
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953992.1"
                     /locus_tag="JIW86_RS15250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15250"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_257554241.1"
                     /transl_table=11
                     /translation="MRKLTYLVATSADGFIADPDGDGDFFNRWLDADYSGAMFGEFPET
                     VPTHVRASLGVEGVEGKHFDAVVMGRGTYDPGLRLGITSPYSHLAQYVASRSLGTSPDP
                     AVEIVSGDVPDRVRKLKEQPGLGIWLAGGADLAGQLVEEIDEFVVKTYPVFAGSGIPMS
                     RAGFGIRELELTDLKRFGGGQVVTTYARRR"
     misc_feature    complement(9146..9157)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.28"
                     /tool="antismash"
     misc_feature    complement(9178..9193)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            complement(9290..9892)
                     /locus_tag="JIW86_RS15255"
                     /old_locus_tag="JIW86_15255"
     CDS             complement(9290..9892)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741540.1"
                     /locus_tag="JIW86_RS15255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15255"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_257554242.1"
                     /transl_table=11
                     /translation="MGLDIRQADQSDRDAVARLLDEAFRTDPVSSWVFPDPEHRAAVHG
                     KFLGVFVDVALAEGRIDYAVDGSAAALWLRIPAGDQEGEAVEDEVPARMRAEADPDNER
                     CELVGRLTGAVHPTAEEHEYLLMIAVAPGRQGEGLGSELMRPVLERCDREGVPAYLEAS
                     SERSKGLYERLGWEFTGEAVRLPDGPLMWPMWRKPRG"
     misc_feature    complement(9915..9929)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(10001..11074)
                     /locus_tag="JIW86_RS15260"
                     /old_locus_tag="JIW86_15260"
     CDS             complement(10001..11074)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741539.1"
                     /locus_tag="JIW86_RS15260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15260"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_257554243.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.8e-57, bitscore:
                     192.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTEAIATGEGQEAAALLERTRETVNPELRRTVESLPGSMRRVA
                     MYHFGWEHADGTPAAGNAGKAIRPALVLAAAQALQGQGHGHGQASGGQVGDAVRAAAAV
                     ELAHNFTLLHDDVIDKDTRRRGRATAWTVFGIPDAIITGDAMMALALRLLAEDPHPASA
                     EASARLAACVIELCAGQQADCAFEQRAYVSLDECLTMATAKTGALLGCACALGALYAGA
                     GPDEADAMDAFGREAGLAFQLIDDLIGIWGDPGHTGKPAGADLLARKKSLPVVAALTSG
                     TEAGEELAALYAGPMSGDDVRKAADAVDRAGGRDWAQAHAADRMGRAVQQLSRAVPDLG
                     AAGGLLALAEFVTRRTR"
     gene            complement(11113..12513)
                     /locus_tag="JIW86_RS15265"
                     /old_locus_tag="JIW86_15265"
     CDS             complement(11113..12513)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741538.1"
                     /locus_tag="JIW86_RS15265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15265"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_215146799.1"
                     /transl_table=11
                     /translation="MSVQAGSETQTPQRSLGTSAARNLATTTKSAPQMQEITSRWLLKT
                     LPWVSVQGGTYRVNRRLSYSVGDGRVEFIKTGTQVQVIPAELGELPLLREYEDLEVLGE
                     LAQRCRQIDFEAGQELTSFGSPSDQVFLLAHGRIDQVGPGPYGDDAVLQTVADGAYFGE
                     DSLADEEAIWEYTARAATSGTALVLSRQDFQLLADRVDSLREHVEHVRTLPAQRTNKYG
                     EAAIDLSAGHQGEAVLPGTFVDYDAHPREYELSIAQTVLRVHTRVADLYNQPMNQTEQQ
                     LRLTVEALRERQEHEMLNNRDFGLLHNTDYDQRIQPHDGAPSPDDMDQLLSMRRGSKFF
                     LAHPKAIAAFGRECNKRGLYPEPVDIGGHHVPAWRGVPIFPSNKIPISDARTTSILCMR
                     TGEEEQGVIGLHQPGIPDEIEPSLSVRFMGISEQAIISYLVTAYFSAAVLVPDALGVLE
                     NVEIGRWR"
     misc_feature    12703..12721
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.64"
                     /tool="antismash"
     misc_feature    complement(12706..12722)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.32"
                     /tool="antismash"
     misc_feature    complement(12707..12725)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.73"
                     /tool="antismash"
     misc_feature    12717..12733
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.17"
                     /tool="antismash"
     misc_feature    12721..12739
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            12741..13205
                     /locus_tag="JIW86_RS15270"
                     /old_locus_tag="JIW86_15270"
     CDS             12741..13205
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031657.1"
                     /locus_tag="JIW86_RS15270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15270"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_257554244.1"
                     /transl_table=11
                     /translation="MRLTRFTDLALRVLMRLAVTDADAAALPTTREVAATMEVPYTHTA
                     KVVARLQHLGLVEARRGRGGGLTLTPAGRDASVGGVVRELEGAGDVVDCDGATPCPLRG
                     GCVLRGALRRAQEAFFAALDPLTVNDLVAAPTGPLLLGISGSSPAGAERP"
     gene            13353..14549
                     /locus_tag="JIW86_RS15275"
                     /old_locus_tag="JIW86_15275"
     CDS             13353..14549
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127491.1"
                     /locus_tag="JIW86_RS15275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15275"
                     /product="globin domain-containing protein"
                     /protein_id="WP_257554245.1"
                     /transl_table=11
                     /translation="MLSEKSTATVRATLPAVGAAIGEITELFYTKLFAAHPELLRDLFN
                     RGNQNAGLQKQALAGSIAAFATHLVAHPDTRPDVMLGRIAHKHASLGVTREQYPVVHRH
                     LFEAIAEILGEAVTPAVAEAWNEVYWLMANALIAIEERLYAEQRIVAGDVWREWTVTGR
                     VEETADCTTFRMTPADGAPAPAFKPGQYVSVQVELPDGARQIRQYSLSTAPGSPVRAIT
                     VKRVHGPAAAGPDGEVSNHLHARVRAGDTLRVSAPYGDLVLRDSTAPVLLASAGIGCTP
                     MLSMLEHLAETGHSAPVTVLHADRSPADHPLRGDHRALTHKLADASARFWYEESAEPGD
                     GTGRLDLTAVPVSPGTRAYLCGPLPFMRSVREQLLAKGVPAADIHYEVFGPDLWLAPA"
     gene            14664..15254
                     /locus_tag="JIW86_RS15280"
                     /old_locus_tag="JIW86_15280"
     CDS             14664..15254
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154135.1"
                     /locus_tag="JIW86_RS15280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15280"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_215146796.1"
                     /transl_table=11
                     /translation="MAAPMSAGRFLDALRAEGLTVVEVGAWRTHNRNHKGPWGPVHGVM
                     IHHTVSNGTANTVSFCRQGDSDLPGPLCHGVITKDGRVHLVGYGRANHAGAGDSDVLAA
                     VIAEKRLPPDHHANTDGNRHFYGFECENLGNGKDPWPAVQLDAITRASAALCRVHAWTA
                     RSVIGHLEWQPGKIDPKGFTMESLRNRIAERLK"
     gene            15280..16173
                     /locus_tag="JIW86_RS15285"
                     /old_locus_tag="JIW86_15285"
     CDS             15280..16173
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266466.1"
                     /locus_tag="JIW86_RS15285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15285"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_257554246.1"
                     /sec_met_domain="PALP (E-value: 3.9e-18, bitscore: 64.7,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPELRPRPPSPLVEAADERFGAYGVRLLLKRDDLVHPELPGNK
                     WRKLAPNLRAAVEGGHRAVATFGGAYSNHLRATAAAGRLLGMETVGIVRGDELAGRPLN
                     GSLARCAADGMRLRFVSRSEYRRKAEPEVLARLLDGAGASEAYVVPEGGSNALALTGCA
                     ELGRELRGAADVVAVACGTGGTLAGLAAGLAPGQRALGVPVLAGGFLAAEIRSLQRQAF
                     GGPAGDWTLAEEFHHGGYARVPAALDAFAADFESRHGLPVERIYVAKLLWALTELTRSG
                     AFPRGTTLAAVITGRP"
     gene            complement(16187..17767)
                     /locus_tag="JIW86_RS15290"
                     /old_locus_tag="JIW86_15290"
     CDS             complement(16187..17767)
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036096.1"
                     /locus_tag="JIW86_RS15290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15290"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_215146794.1"
                     /transl_table=11
                     /translation="MEVLQLVALVAGSAVVAGVARRTPVPAPLLLVAAGLFAAYVPGVP
                     EYTLDPHIVLPLLLPPLLHTAAVDSSYLDLRANIRPIAMLSVGYVLFATIAVGYAAYLV
                     VPGLSLPVALVLGAVVAPPDAVAATAIARKLRLPNRITTILQGESLVNDATAITAYKVA
                     LAAAVGVSAGWAGGIAEFLLASVGGVGVGLLLMVPIHQLRKRLKEPLLQNTLSLLIPFV
                     AYAAAERVHASGVLAVVVVALYLGHRNWQVDFATRLQEEAVWKVISFVLESVVFALIGL
                     QLPVVLKGLGEYEGAAAAWYAVAVFLAVVVARFLWVFPATFMPRWMSARIRTREPDTDW
                     KAPVVVGWAGMRGVVSLAIAFSVPMTVPHRNLILFLTFTTVIGTLVIQGLTLPPLIRML
                     RLPPRDLQAETLMEAQAQSEASTAADERLTELLEAPANQLPPPLADRLRTVLERRRNAV
                     WERLGEVNPVTGESADEVYRRLAREMIEAEREVFVTLRDRRRIDDEMLRGLLRRLDLEE
                     AAAYREETA"
     gene            17832..18092
                     /locus_tag="JIW86_RS15295"
                     /old_locus_tag="JIW86_15295"
     CDS             17832..18092
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966374.1"
                     /locus_tag="JIW86_RS15295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15295"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_215146793.1"
                     /transl_table=11
                     /translation="MSECTHVAELPRPEPIPSAQTCTECLALGSHPVQLRMCLGCGYVA
                     CCDSSPYRHATAHHKDTGHPVMRSFEPGEIWRWCFVDGSIV"
     gene            18297..18710
                     /locus_tag="JIW86_RS15300"
                     /old_locus_tag="JIW86_15300"
     CDS             18297..18710
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966375.1"
                     /locus_tag="JIW86_RS15300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15300"
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_030153599.1"
                     /transl_table=11
                     /translation="MSQIAGEPGTQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGRAPERDTFAWTV
                     LSALAGKVESTVEEDRTVSISLYKQRGAGPGPA"
     gene            18707..19762
                     /locus_tag="JIW86_RS15305"
                     /old_locus_tag="JIW86_15305"
     CDS             18707..19762
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266462.1"
                     /locus_tag="JIW86_RS15305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15305"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_257554247.1"
                     /transl_table=11
                     /translation="MSGGEIPVRGGDRPRVRHEVDGSIPEQQHARPHPADTDAEDGFLD
                     SAERRAGPMSDNQHEEPQPAQPPAAAATAPEVPVPPEVPVLPEVPAFQPTAPLPDPRDR
                     SGARALFIELRALPDGSVEKAELRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVATIG
                     LIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLSLTTATAEL
                     SQQHGRSPTVHELAERLGISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGSED
                     EALEGVEYRESLKPLLEGLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTL
                     AQLREKLLVEE"
     gene            complement(19793..20242)
                     /locus_tag="JIW86_RS15310"
                     /old_locus_tag="JIW86_15310"
     CDS             complement(19793..20242)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700024.1"
                     /locus_tag="JIW86_RS15310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_15310"
                     /product="hypothetical protein"
                     /protein_id="WP_257554248.1"
                     /transl_table=11
                     /translation="MSKKQPANAAAPATTPAAALPGRLTAAAALTALEGLALAGLGVYM
                     LFVGIAGDPDSPQQAETGGITLLALAALPLIAARGLRLGRRWSRGPALITQLMALPVAW
                     TLYSTGGAMIAAAVALGVAAVAVAALLVNPTATEALGIGPGEQAR"
     misc_feature    20918..20933
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
ORIGIN
        1 cagggccgcc gccacgtcgg ggtcgacacc gacgatcttg ccgccctcgg tgaactccat
       61 cggagcgtag gtcgcgtccg taccgacctt gatgacaccc gcgtcctgga tcttcttcgg
      121 aagcttcgag aagagcggtg cgctgctgtt gttcgcctgg cccgacgggg tcgtggaggc
      181 cttgtccgtc tggtcgccac agccggtgag gatcagggcg ccggcgaccg cgatcgcgcc
      241 gaccgcggcg atccgggacc gtgcggcggt cgtacgacgg gtgatgcttg cggtcatgag
      301 cgggttcctc cggctggtgg aaaagcaccg aaaaatggtc gggcacgcac catcgagtgt
      361 cgcgaccttg tgtgattacg gcatcttgcc attcggactg ccgcattcag ggtgcccgtg
      421 aggtcaaaat cagataacgg acacgcccga cgacccaaca ggactgcggg caagggccct
      481 cggagccgca caaaacgccg tgaccagccc gtttgggctc actatttgcg gcgcgtctcg
      541 cccattggac acaagggttt ggacttttag ccaaaaccat gacaagcagc ctatggtcga
      601 gccggaatcg actcgtctgg gtgagcgttc atccggtaga acagatcctt acacccctca
      661 tccggggctc agggcgcgcg tgcggcgcgc ccgcgcgtac gaacctcccc tccgcggagg
      721 cggtccaacc gtcgatgcgg agtacgaacg cggtgcccgc ccacccctta accaggagtg
      781 gccaccctca acgattcaaa ggacttaagg ggtcacacaa agtggcagcg gagatcgtca
      841 accctcacac tgacagcgcg acggacaaca acccggacgc ggtgttcgcg ctgcaccggg
      901 gcggcaagat ggccatccag gccacggtgc cggtcaacaa caaggacgac ctgtccctcg
      961 cgtacacccc cggcgtggcg aaggtgtgca gcgccatcgc cgagcagccg gacctggtga
     1021 acgagtacac ctggaagtcc aacgtggtcg ccgtcgtcac cgacggcacg gccgtgctcg
     1081 ggctcggtga catcggtccc gaggcctccc tccccgtgat ggagggcaag gccattctct
     1141 tcaagcagtt cggcggcgtg gacgcggttc cgatcgcgct cgcgaccaag gacacggacg
     1201 agatcatcga gacggtcatc cgtctcgcgc cgtccttcgg cggggtgaac ctggaggaca
     1261 tctccgcgcc ccgctgcttc gagatcgagc gccgccttca ggaggcgctc gacatcccga
     1321 tcttccacga cgaccagcac ggcacggcca tcgtcacgct ggccgcgctg cgcaacgccg
     1381 cgaagctcac cgggcgcacg ctcggcgacc tgcgcgccgt gatctcgggt gcgggcgccg
     1441 cgggcatcgc catcgccaag atcctggtgg acgcgggcat cggcgatgtg tgcgtgacgg
     1501 accgcaaggg cgtcgtctcg gccgaccgct cggacctgac ggacgtcaag gcggagatcg
     1561 cgggcctgac caacaagacg ggccagaccg gctcgctgga gaaggccctc gcgggcgcgg
     1621 acgtcttcat cggcgtctcc ggcggcacgg tccccgaggc ggcggtggcc tcgatggcga
     1681 aggacgcgtt cgtcttcgcc atggccaacc cgaacccgga ggtccacccg gacgtcgcgc
     1741 acaagtacgc ggcggtcgtg gccacgggcc gctcggactt cccgaaccag atcaacaacg
     1801 tgctggcctt cccgggcatc ttcgcgggcg ccctcaaggt gcgcgccacc cggatcaccg
     1861 agggcatgaa gatcgccgcc gccgacgcca tcgccggcgt cgtgggtgac gagctcgccg
     1921 ccgactacgt gatcccgtcg ccgttcgacc cgcgcgtcgc ggaggccgtc tcctcggccg
     1981 tcgccgccgc ggcgaaggcc gacggcgtgg cccgcctggc ctgatctccg caacaagctg
     2041 tacgggcagc ggcccggccg gatccatccg gccgggccgc tgcctttttt acgcgccgct
     2101 cgcccggtgc gacgaagacc tcaccgtccc ggtcccggag gggctggaac cccggcctac
     2161 ccagcggtag cgtcgcggca tgttcgctgc ctatgccgcc cgaatcgacc gtgaccaccc
     2221 gctgaacggc ctggagctgg gtgagcgccc cgctcccgag gcccgccccg ggtgggtgac
     2281 cgtgaacgtc aaggccgcct cgctcaacca ccacgacctg tggtcgctgc gcggggtggg
     2341 cctcggccag gacaaactcc cgatgatcct cggctgcgac gccgccggga ccgaccagga
     2401 cggcaacgag gtcgtcctgc actccgtgat cggccagagc ggtcacggag tcggcccgga
     2461 cgagccccgc tcgatcctga ccgagcgcta ccaggggacc ttcgccgagc aggtcaccgt
     2521 gcccgcctgg aacgtcctgc gcaagcccgc cgggctctcg ttcgaggagg ccgcgtgtct
     2581 gccgacggcc tggctgacgg cgtaccggat gctgttcacc aacgccgggg tccgccccgg
     2641 ggactccgtc ctcgtccagg gcgccggcgg cggggtggcc accgccgcca tcgtcctcgg
     2701 caaggcggcc ggcctgcgcg tcttcgccac cagccgggac gaggccaagc gcaagcgggc
     2761 ggtggaactg ggcgccctgg aggcgtacga gcccggcgcg cggctgccgc agagggtgga
     2821 cgcggtgatc gagacggtgg gcgcggccac ctggtcgcac tcggtgaagt ccctgcgccc
     2881 gggcggcacc ctggtcatct ccggcgccac gagcggcgac cgcccggagc acgccgagct
     2941 gacccggatc ttcttcctgg agctgaaggt ggtcggctcg acgatgggct cgaaggacga
     3001 gctggaggac ctgctgtcgt tctgcgcgac caccggggtg cggccggtca tcgacgaggt
     3061 gctgccgctg gaccgggcgc gcgaggggtt cgagaagctc gcgtcgggcg acctcttcgg
     3121 gaagatcgtc ctcaccccgt agcccgcacc cgggcgtcaa taagggttga caccccctcc
     3181 cgcgtcaacc tacattgaca tccatgacgg aagctaccga cctcgccgag cgggccggcg
     3241 accgcgaccc gcgtgtgggc ctgcgtgccg tggccgccct ccgcagactg ctggagcagc
     3301 tggaggccgt acaggtacgc agtgcccgca cgcagggatg gtcctggcag gagatcgcgg
     3361 ccgagctggg cgtcagccgg caggccgtgc acaagaagca cgggaggctt tgatgttcga
     3421 acgcttcacg accgaggccc gcgacaccgt gacgggcgcc gcggccgagg cccggcaggc
     3481 cggatccgcc acggtcaccg aggaacacct gctgctcgcc ctgctgtccc ggggcgcctt
     3541 ggacttcctg ggcgtcgacc gtgcggcggt ggccgcggac ctcgccgcgg cccgccgccg
     3601 gggcggcatg tccagggcgg acgaggaggc gctggccggg ctcggcatcg acctctctga
     3661 gatcgtctcc cgcgtcgagg aggcccacgg cgagggcgcg ctgtccccgg cggccccccg
     3721 gcggcggacg cggcacgtcc ccttcaccca gggcgcgaag aaggtcctgg aacagtccct
     3781 gcggatcgcc ctgggccgca aggaccgccg catcgccgcc ccgcacctgc tactggcact
     3841 gctctcccgc cccggcacgg tcgccgaggt cctgacggac cacggcgtca cgtacgcgac
     3901 cgcggagacg ggcctggcag cctagtcacg caccgttgag agcggccttg aggcgggagg
     3961 ccgccgcggc gaggtgggcg cgggcctcgg ccagctgggc cgcggacacc ccgtggtcgc
     4021 gggccgcgtc gcggacgtcg tcacggaaac ggtccagcag ccggtccagg tccctggccg
     4081 ggtcgccggt gggggtcagg tcctcggccc agccggtgtc ggccaccggg ggcgccgcgg
     4141 agtcggccgg cgcgctcggc tgggtcggcg cggtcggcgt cgtaccgccg ccgagccagg
     4201 ctccggccag actgcccagg accccgcccg acttggcaaa ctgctcctgg agctggcccg
     4261 cgatgcgctg gacctcctca cgggcccgct cctgggcctc cttggcctga cggcgggcct
     4321 gctgggcctc ctcgcgggcc cggcggctct cgtccttcgc ccgccgagcc tgctccttcc
     4381 actcctgccg ggccttgctc atctcctcct tgatcgtctt ccaggactcg tcgtcgaccc
     4441 tcgtcgccga cgcggaggcc gccgcccgca tctcgcgccg caggtcaccg gccgcacccc
     4501 ggacgtcgtc gcggatctcg gcggccagtt cggtgaccga gtcgcggatc tccagctcca
     4561 ggtcggcgag ttcgccgccg cggtcggcca gttcggcccg gcccgcctcg gtgatcgagt
     4621 acaccttgcg cccgccttcg gtggcgtgcg tgaccaggcc ctcggcctcc agcttggcca
     4681 gccgcgggta caccgtgccc gcagagggcg cgtacaggcc ctggaaacgc tcctccagca
     4741 gtcggatcac ctcgtacccg tgccgcggag cctcgtccag cagcttgagg aggtagaggc
     4801 ggaggcggcc gtgggcgaag acgggcggca tgtcagagca ccttcttgtc gagcgcgagc
     4861 ggggtggggg cggaggccgt gccgtcggtg tcggccgggg ggcggcgcag cagtgcgatc
     4921 gctcccgaga ccgtggtggc gcgcagggtg ccggtgcccg agccgagggt tccggtgatc
     4981 cgcttggagc ccagctggcc ggagacccgc aggtcctcga aggcgttgga gacgccgccg
     5041 gtggcggtgt tggcctccac gcgggcgtcg gcggggtgcg gcaggcggat ggcgacctgg
     5101 ccggacacgg agttcaccgc gatgtccacc ggacgcgggg cggacgggtc gaggtccagg
     5161 tcgatgagca tgtcgccgct gaccgagtcg ccccgtacgc tcacgcccgc gccgtcgacg
     5221 accgtcaggt cgccggacac cgagtggaag ccgaggtcgc cggtgacgga ctgggcctcg
     5281 acgttgccgg agacggtgtg cgccttgacc ttgcccgaca gcccggacag cgtggcgccg
     5341 ccggagaccg cgttcacctc ggtgccgccg gagattccgg agacgaagga ggtcgcgtcg
     5401 accacggcca cctccacgtg cgtggtggcg gggacggtga gggtgacggc ggcactgcgc
     5461 tcccacgcct tgcggccgga ggcggaactc gaccaggcct tccagggctt ggcctcccac
     5521 cacttcttga agccctggga cccgttccag ggcaggtcct cgtaggagac ggtgagggtg
     5581 ccgccctcct gcaccacgta caggggcggt ccgtcgacct cggtcacctc caggcgggcg
     5641 gggccctcct cggcggcgat cacgttcacc gtgccgctca cgaggcggac gcggagcctg
     5701 gtcacgggct cctcgaaggt gagcttctgc gcttcggcga tgtgccacgt cgactgcgac
     5761 gcctgctcgg ccatggggct gatcctcctc gtgcgttcac ggacgggact cgacgcacgc
     5821 aacatatcgc gtcttctgag taacacgata tatcgcggtt gggggaagtc aagcatgccg
     5881 ccgagatccc cgctctgagc caattgaggc gatttacctt gaggtgtggg catgccgatc
     5941 tccggcgagc gggttccggt gcgccgccgc gtacgagtgg gacgagcggg gccggccgga
     6001 cggcgagccg gacgggctga ccccgggaga gcccgccgac cggctgcggg agtcggtccg
     6061 ccggcgcagc cccggctggg cggcggccgg ggccgtcctg acggcccagg gtgccccgtc
     6121 cctggcgtac gaccacgccc gccggtcccg ctgaccaggc cggggccgct gcgcggggct
     6181 tcccccgccc cgccccttct cccccagcta ccgctgggag gtgcccccag aaaccgggct
     6241 ccgcccggac cctcccccag actccgtccg gggggacccc cactcaaacg ccggcgaggc
     6301 tgggttgtgc cagccggacg gcatcagcca aaatccagcc ccgcctgggg gcccctccca
     6361 gcggtagctg ggggagtttg aggcgcgggg tctggggcgg agccccagca gcggcgccgc
     6421 accggtccgg cctgcgtccg gcggagccca ccggcggagc cccagcagcg gtgccgcagg
     6481 gctacgccgc ctccaggagc gggctcgcgt ggtggtggag ccatgcccgg tacgggggcg
     6541 tgcgcagggc cgcctcgcga taggcggcgc ggaggtcctc gtagacctcc gcatgggcgc
     6601 cgggccgggt cgccaggagc agccgcacgg cgagggggtc gccggacagc ggccggatcg
     6661 ccatgtcctc gcgcggcccg gaggtcggct ggcagggagc caccgcctcg ccggagacga
     6721 tcagcgagct cgcggtgtgg tagtcggcgt gcagcaccgg cgggtccagc cccgcaccgg
     6781 cgaagaccct ccgcaggccg tcccattcgc cgtcgaccga cgggtccacc atccagcggt
     6841 cgtcggccag gtcccgtaag gacaccaccg cctgcccggc ggccggatgg tcccgggaca
     6901 tcgacacgaa ctgcggctcg cgctccatca gcacgtgcag ctgcagcccg gccggcaccc
     6961 gcagcggact gccctctacc tcgtgcacga aggccacgtc cagttgtccc gaagccacca
     7021 tcctcagcag cgcgttggcc gacacgtcca ccaccagcga ggtctcggtg tccggaagcc
     7081 gccggtggat ccgccggagc cagcccggca gcgcacggct ggccgtggag ccgatccgca
     7141 gccgcggccc gtgcgccagc gcccgggcct ccgccaccag cgcggccatc tcggcgagca
     7201 gcggacgggc ccggcccagt acggtgcgcc cgaagggggt gggccggcag ccggtccggt
     7261 cgcgcaggaa cagctcgccg tccagggccc gttcgatacg gcgcagctgg gtcgtgaggg
     7321 agggctggct cacgccgagg tgccgggcgg ccttgtgcag actcccggcg tcggcgatgg
     7381 cgcacagcgc gcgcaggtgc ctgacctcaa gctccatgtc ccgagggtag gccgcggccg
     7441 ggggacaaca ccagccaccg atagcccccc taatcccgcc attctcatac cagttgctct
     7501 gtcgaaatct ccccgatagg cccgcgctat cggggagtga catcatccgc cgggcacttc
     7561 cgctccctca gactccggtt cgaacgacca ccccccaccg caccggacga gtaggagctc
     7621 ccccacatgc gccactcccg taaggccgtt ctggccacca ccatcggcct cggcctcgcc
     7681 gccgccctcg gcgtcgtccc caccgccacc gccgccaccg cccccgccgg cactcccgcg
     7741 agctacgcgg cgtacgacaa ctcgcaggag aaccaggccg ccaacaaggc cttcttcgag
     7801 gccgttcagc gctcggtcgc cgagcagcgc gccgcgaacc cgggcatcct ggccgtgacc
     7861 gtcacctaca acacccgcaa cgcgccgagc ttccgcaccc agatagcccg ctccacgcag
     7921 atctggaaca gctcggtgac caacgtcaaa ctgcaggagg tctcctccgg cgggaacttc
     7981 tcgtaccgcg agggcaacga ctcgcgcggt tcgtacgcga gcacggacgg ccacggccgg
     8041 ggctacatct tcctcgacta ccggcagaac cagcagtaca actccacccg ggtgacctca
     8101 cacgagaccg gtcacgtgct gggtcttccg gaccactact cgggtccgtg cagcgagctg
     8161 atgtcgggcg gcggcccggg cacctcgtgc cagaacgcca ccccgaacag caccgagcgg
     8221 gcgcgcgtca accagctgtg ggccaacggc ctcgtcgcct ccggcctgga cacgaagggc
     8281 taggaaggac cggaccgggg ccgggccggg ccgggcctgg ctagggccgg gccccctccg
     8341 gagccacgta ccgcgggcag tccgggttcc ggcaggaacc cgccacccac tccggaatga
     8401 agatcccgag ggacttgcgc cttctgatca gcgtatcgac ggggctcccg cataccgggc
     8461 acatctgctg ctcgtgcccg gcatgcgggg ctaccgtctc ctgcgcgtgc tgctgctcgt
     8521 caccggccat acctccacgg taggccggtt tcgcgcgtcc ggcggagtca gcgcctgcgc
     8581 gcgtacgtgg tcacgacctg gcctccgccg aagcgcttga ggtcggtcag ctccagctcg
     8641 cggatcccga agccggcgcg cgacatcggg atgccggatc cggcgaacac cgggtacgtc
     8701 ttgaccacga actcgtcgat ctcctcgacc agctgtccgg ccaggtccgc gccgccggcg
     8761 agccagatcc ccagacccgg ctgctccttc agcttccgca cccgatccgg cacgtcgccc
     8821 gagacgatct ccacggccgg gtcgggcgag gtgccgaggg agcgggaggc gacgtattgg
     8881 gccagatggg agtacgggct ggtgatcccc agcctgagcc ccgggtcgta ggtgccgcgc
     8941 cccatcacga ccgcgtcgaa gtgctttcct tccaccccct cgacacccag ggacgcccgg
     9001 acgtgcgtgg gcaccgtctc cgggaactcc ccgaacatgg cgccggagta gtccgcgtcc
     9061 agccaccggt tgaaaaagtc gccgtctccg tccgggtcgg cgatgaagcc gtcggcggac
     9121 gtggcgacga ggtacgtgag cttgcgcaag cggtttctct tccgttcgac aggggggtac
     9181 ctcccagcgg tagctggggg agccaccaca ccgaggcacg tcaaataaag tacttcagat
     9241 gaagtggtta cgcaaacagc cccgtcgccg ccccgcggcg accccgcgac tacccgcgcg
     9301 gtttgcgcca catcggccac atcagcggac cgtccgggag cctgaccgcc tcgcccgtga
     9361 actcccagcc gagccgctcg tacagcccct tgctgcgctc gctgctcgcc tccaggtacg
     9421 ccggcacgcc ctcccggtcg cagcgctcca gcacgggccg catcaactcg ctgcccagcc
     9481 cctccccctg ccggcccggg gcgaccgcga tcatcaggag gtactcgtgc tcctccgccg
     9541 tcgggtgcac cgcgcccgtg agccggccga ccagctcgca ccgctcgttg tcggggtcgg
     9601 cctcggcccg catcctcgcc gggacctcat cctcgacggc ctccccctcc tgatcgcccg
     9661 ccgggatccg cagccacagc gcggccgcgg aaccgtccac cgcgtagtcg atccggccct
     9721 cggccagcgc cacgtccacg aacaccccga ggaacttgcc gtgcaccgcg gcccggtgct
     9781 cggggtccgg gaagacccag ctgctcaccg ggtcggtccg gaaggcctcg tcgagcagcc
     9841 gcgccaccgc gtcccggtcc gactgatccg cctgacgtat gtccagcccc atgggcctca
     9901 cccttcgctc aatcatcaac aaccttgagc gatcctagag ttgggcccga tgcgcggaca
     9961 gcccggttcc ggcacccgtc ggcgccggaa ccggaccccc tcaccgtgtc cggcgcgtca
    10021 cgaactccgc gagagccagc agcccgcccg ccgccccgag gtccggtacg gcccgggaca
    10081 gctgctgcac ggcccggccc atccggtcgg cggcgtgggc ctgcgcccag tcccgaccgc
    10141 cggcccggtc caccgcgtcg gcggccttgc gcacgtcgtc cccgctcatg gggcccgcgt
    10201 acagggcggc cagttcctcc cccgcctcgg tgcccgaggt gagggcggcc accaccggca
    10261 gggacttctt gcgggcgagc agatcggccc cggcgggctt gccggtgtgc cccggatccc
    10321 cccagatgcc gatcaggtcg tcgatcagct ggaaggccag acccgcctcc cgcccgaagg
    10381 cgtccatcgc gtcggcctcg tccggcccgg cgcccgcgta cagcgcgccc agggcgcagg
    10441 cgcagcccag cagggccccc gtcttggccg tcgccatggt cagacactcg tcgagcgaga
    10501 cgtacgcgcg ctgctcgaag gcacagtccg cctgctggcc cgcgcacagc tcgatgacgc
    10561 aggccgcgag ccgcgccgag gcctccgccg acgccggatg cggatcctcc gcgagcaggc
    10621 gcagcgccag cgccatcatc gcgtcgcccg tgatgatcgc gtccggtatc ccgaagacgg
    10681 tccaggccgt ggcccggccg cgccgccggg tgtccttgtc gatgacgtcg tcgtgcagca
    10741 gcgtgaagtt gtgcgccagc tccacggccg ccgccgcccg gacggcgtcg cccacctgcc
    10801 cgcccgacgc ttgcccgtgc ccgtgccctt gcccttgcag ggcctgggcc gcggccagca
    10861 ccagggccgg ccggatggcc tttccggcgt tgcccgcggc cggtgtgccg tccgcgtgct
    10921 cccagccgaa gtggtacatc gcgacgcgcc gcatggaacc gggcaggctc tcgaccgtcc
    10981 ggcgcagttc cgggttaacc gtttctcttg tccgttccag cagggccgcg gcctcctgac
    11041 cctcaccggt cgcgatcgcc tcggtggtcg ccatggcgtg tccgtgtccc cgacgctctt
    11101 cggccggccg cctcagcgcc agcggccgat ctcgacgttc tccagtacgc cgagcgcgtc
    11161 cggcaccagc accgcggcgg agaagtaggc ggtgaccagg tacgagatga tcgcctgctc
    11221 gctgatcccc atgaagcgga ccgacaggct cggctcgatc tcgtccggga tgcccggctg
    11281 gtgcaggccg atcacgccct gctcctcctc gccggtacgc atgcacagga tggacgtggt
    11341 gcgggcgtcg ctgatcggga tcttgttgct cgggaagatc ggcaccccgc gccaggccgg
    11401 cacgtgatgg ccgccgatgt cgaccggctc cgggtacagc ccgcgcttgt tgcactcgcg
    11461 gccgaaggcg gcgatggcct tggggtgcgc gaggaagaac ttggagccgc gccgcatgct
    11521 gagcagctgg tccatgtcgt cggggctggg cgcgccgtcg tgcggctgga tgcgctggtc
    11581 gtagtcggtg ttgtggagca ggccgaagtc gcggttgttg agcatctcgt gctcctggcg
    11641 ctcgcgcagc gcctcgaccg tgagccgcaa ctgctgctcg gtctggttca tcggctggtt
    11701 gtacaggtcg gcgacgcgcg tgtgcacccg caggaccgtt tgtgcaatgg agagttcgta
    11761 ctcgcgcggg tgggcgtcgt agtccacgaa ggtgccgggg agcacggcct cgccctggtg
    11821 gccggcggag aggtcgatgg ccgcctcgcc gtacttgttg gtgcgctggg cgggcagcgt
    11881 ccgtacgtgc tccacgtgct cgcgcagcga gtccacgcgg tcggcgagca gctggaagtc
    11941 ctgccgggac aggacgagcg cggttccgga ggtggcggcg cgggcggtgt actcccagat
    12001 cgcctcttcg tcggcgaggg agtcctcacc gaagtacgcg ccgtcggcga cggtctggag
    12061 gactgcgtcg tccccgtagg ggcccgggcc gacctggtcg atgcggccgt gggcgaggag
    12121 gaagacctgg tcggaggggc tgccgaagga ggtgagctcc tggccggcct cgaagtcgat
    12181 ctgccggcac cgctgggcga gttcgccgag cacctcgagg tcttcgtact cccgcagcag
    12241 cgggagctcg ccgagctcgg ccgggatcac ctggacctgg gtcccggtct tgatgaactc
    12301 cacgcgcccg tcgccgaccg agtagctcag ccgtcggttg acgcggtacg tgccgccctg
    12361 cacggaaacc cacgggagcg tcttcagcag ccaccgggag gtgatctcct gcatctgcgg
    12421 cgcggacttg gtcgtggtcg ccaagttccg cgcggccgat gtccccagac tgcgctgcgg
    12481 cgtctgggtc tcggaacctg cctggaccga catgtgtatc cctttcgatc actccatgac
    12541 tctgcgggat gcagccttcc agtgcggaac gtgatgggac cattacacaa aaggatggga
    12601 ctactccgtc tgggcgtggg gcactcttct gggtccacct ccttcccacg cgcccctctg
    12661 gacccaccgg tttcagccac cgcaccccac cgcgggcgtc atattttgca ttgtggatgc
    12721 aagttttcta cggtggacgc atgcggctga cccgattcac cgacctcgcc ctgcgcgtcc
    12781 tgatgcgcct ggccgtcacg gacgccgacg cggcagccct ccccacgacg cgcgaggtcg
    12841 cggcgaccat ggaggtcccg tacacccaca cggcgaaagt ggtcgccagg ctgcagcatc
    12901 tcggcctagt cgaggcgcgg cgcggccgcg gcggcgggct caccctgacc cctgccgggc
    12961 gcgacgcctc ggtgggcggg gtggtgcgcg aactggaggg cgcgggcgat gtcgtggact
    13021 gcgacggcgc caccccctgc ccgctgcgcg gcggttgcgt gctgcgcggc gcactgcgcc
    13081 gggcccagga ggccttcttc gccgctctgg acccgctgac ggtgaacgac ctggtggcag
    13141 ccccgaccgg accgctcctg ctgggcatct cgggcagttc gccggcgggg gccgaaagac
    13201 cctgacaccc agggccgaat ggccgattcg cagcggcgtc cggcctgcct aggctgcccc
    13261 cgacggcagt tcgaacggaa gtccgcacca tggcggaccc gcgttcaaaa acatgcatct
    13321 catataccaa ttccatttcg cgaggagtcc cgatgctttc cgagaagtcg accgcgaccg
    13381 tacgagccac cctgcccgcc gtgggcgcgg cgatcggcga gatcacggag ctcttctaca
    13441 cgaagctgtt cgcggcccac ccggaactcc tgcgcgacct cttcaaccgg ggcaaccaga
    13501 acgccggcct ccagaagcag gccctggccg gctccatcgc cgccttcgcg acccacctcg
    13561 tcgcgcaccc ggacacccgc cccgacgtga tgctgggccg catcgcccac aagcacgcct
    13621 ccctgggcgt cacccgcgag cagtacccgg tcgtccaccg gcacctcttc gaggcgatcg
    13681 ccgagatcct gggcgaggcg gtcacccccg cggtcgccga agcctggaac gaggtctact
    13741 ggctgatggc caacgccctc atcgccatcg aggagcgcct ctacgccgag cagcggatcg
    13801 tcgccgggga cgtgtggcgc gagtggaccg tcaccggccg agtcgaggag accgcggact
    13861 gcaccacgtt ccggatgacc cccgccgacg gggctccggc gcccgccttc aagcccggcc
    13921 agtacgtctc ggtgcaggtc gaactccccg acggcgcccg ccagatacgc cagtacagcc
    13981 tctccaccgc ccccggctcc ccggtccgcg cgatcaccgt caagcgggtc cacggtccgg
    14041 ccgcggcggg cccggacggc gaggtctcga accacctcca cgcccgggtc cgggcaggcg
    14101 acaccctgcg ggtctcggcc ccgtacggcg acctggtcct ccgtgactcc accgccccgg
    14161 tcctgctcgc ctcggccggc atcggctgca ccccgatgct ctcgatgctg gaacacctcg
    14221 ccgagaccgg gcacagcgcc ccggtgaccg tcctgcacgc cgaccggtcc ccggccgacc
    14281 acccgctccg cggcgaccac cgggcgctca cgcacaagct ggccgacgcg tcggcccggt
    14341 tctggtacga ggagtcggcc gagccgggcg acggcacggg acgcctcgac ctgaccgccg
    14401 taccggtctc gcccggcacc cgtgcctacc tctgcggacc gctgcccttc atgcgctctg
    14461 tgcgcgagca gctgctggcc aagggcgtgc cggccgccga catccactac gaggtgttcg
    14521 gcccggacct gtggctcgcc ccggcctgac cgctgtccgg atccgctcgc tcgccgtacg
    14581 aatccactgg cgcggaagaa ccccctccac tacaccggag agtagcgacg tggacacaca
    14641 gggtgtccac ggaaggaggg gtcatggccg cacccatgtc cgcgggccgg ttcctcgacg
    14701 cactgcgcgc cgagggtctg accgtcgtcg aagtgggcgc ctggcgcacc cacaaccgca
    14761 accacaaggg cccctggggg ccggtgcacg gggtgatgat ccaccacacc gtctccaacg
    14821 gcacggcgaa cacggtgtcc ttctgccgcc agggcgactc cgacctcccg ggcccgctct
    14881 gccacggcgt gatcaccaag gacggccggg tccacctggt cggctacggc cgcgccaacc
    14941 acgcgggcgc cggggactcc gacgtcctcg cggcggtgat cgccgagaag cggctgccgc
    15001 cggaccacca cgccaacacc gacggcaacc gccacttcta cggcttcgag tgcgagaacc
    15061 tcggcaacgg caaggacccc tggccggcgg tccagctcga cgcgatcacc cgcgcgtccg
    15121 cggccctgtg ccgcgtccac gcctggacgg cccgctccgt gatcggccac ctggaatggc
    15181 aaccgggcaa gatcgacccc aagggcttca cgatggagtc cctccgcaac cgcatcgccg
    15241 agcgccttaa gtagggcgcc gaccagggac aatggccggg tgacccaccc cgaactgcgc
    15301 ccgcgtccgc cgtccccgct cgtcgaggcg gcggacgagc ggttcggcgc gtacggggtg
    15361 cggctgctgc tgaagcggga cgatctcgtg catcccgagc tgccggggaa caagtggcgc
    15421 aagctcgcgc ccaatctgcg ggccgccgtg gaggggggac accgggcggt ggccaccttc
    15481 ggcggggcct actcgaacca cctgcgcgcc accgcggccg ccgggcggct gctcgggatg
    15541 gagaccgtcg gcatcgtgcg cggcgacgag ctggccgggc ggccgctcaa cggctccctc
    15601 gcacggtgcg cggccgacgg gatgcggctg cgcttcgtgt cccggtcgga gtaccgccgc
    15661 aaggccgagc ccgaggtgct cgcccggctg ctggacgggg caggcgcgag cgaggcgtac
    15721 gtggttcccg agggcggcag caacgccctc gcgctgaccg gctgcgcgga gctcggccgg
    15781 gaactgcggg gcgcggccga tgtggtggcc gtggcctgcg ggaccggcgg gaccctggcc
    15841 ggcctggccg ccggactcgc ccccgggcag cgggcgctgg gcgtaccggt cctggcgggc
    15901 ggcttcctgg cagcggagat acgttccctc cagcggcagg ccttcggcgg tccggccggc
    15961 gactggaccc tggccgagga gttccaccac ggcggctacg cccgcgtgcc ggccgcgctg
    16021 gacgccttcg ccgccgactt cgagtcccgg cacggcctcc cggtcgagcg gatctacgtc
    16081 gccaaactgc tgtgggccct gaccgaactc accaggtccg gcgccttccc ccgcggcacc
    16141 accctggccg ccgtgatcac gggccggccc tgacccgcgg aggggatcac gccgtctcct
    16201 cgcggtacgc cgccgcttcc tccaggtcca gccggcgcag cagcccgcgc agcatctcgt
    16261 cgtcgatccg gcggcggtcc cgcaacgtca cgaagacctc ccgctccgcc tcgatcatct
    16321 cccgcgcgag gcgccggtag acctcgtccg ccgactcccc cgtcaccggg ttgacctcgc
    16381 ccagccgctc ccacaccgcg ttccgccgcc gctccagtac cgtccgcagc cggtccgcca
    16441 gcggcggcgg cagctggttg gcgggcgcct ccagcagctc cgtcagccgc tcgtccgccg
    16501 ccgtcgaggc ctcgctctgc gcctgcgcct ccatcagcgt ctctgcctgg aggtcccgcg
    16561 gcggcagccg caacatcctg atcagcggcg gaagggtgag tccctggatg acgagcgtgc
    16621 cgatgaccgt cgtgaacgtg aggaacagga tcagattccg gtgcggcacc gtcatgggca
    16681 cggagaaggc gatcgcgagc gagaccaccc cccgcatccc ggcccacccc acgaccaccg
    16741 gcgccttcca gtcggtgtcc ggttcccgcg tccggatccg cgccgacatc cagcgcggca
    16801 tgaaggtcgc cgggaagacc cacaggaagc gggccaccac caccgcgagg aacaccgcga
    16861 ccgcgtacca ggccgcggcc gccccctcgt actcccccag ccccttcagc accaccggca
    16921 gctggagtcc gatcagcgcg aagaccaccg attccagtac gaaggagatc accttccaca
    16981 ccgcctcctc ctggagccgg gtcgcgaagt cgacctgcca gttgcggtgc cccaggtaca
    17041 gcgccaccac gaccacggcg agcacccccg aggcgtgcac ccgctcggcc gccgcgtacg
    17101 ccacgaaggg gatcagcagc gagagggtgt tctggagcag cggctccttc agccgcttgc
    17161 gcagctggtg gatcggcacc atcagcagca ggcccacgcc gaccccgccc accgaggcca
    17221 gcaggaactc cgcgatcccg cccgcccagc cggcgctgac cccgaccgcg gccgccaggg
    17281 ccaccttgta ggcggtgatg gccgtggcgt cgttcaccag ggactcgccc tgcaggatcg
    17341 tcgtgatgcg gttcggcagc cggagcttgc gggcgatcgc ggtggcggcg acggcgtccg
    17401 gcggcgcgac caccgcgccc agcaccagcg cgaccggcag cgacagcccc ggcaccacca
    17461 ggtacgccgc gtacccgacg gcgatcgtcg cgaacagcac gtagcccacc gacagcatcg
    17521 cgatgggccg gatgttcgcc cgaaggtcca ggtacgagct gtccaccgcg gccgtgtgca
    17581 gcagcggcgg gagcagcagg ggcagcacga tgtgcgggtc gagggtgtac tcgggcaccc
    17641 ccggcacgta cgcggcgaac agcccggcgg cgaccagcag cagcggcgcc ggaaccggcg
    17701 tccggcgggc cacgccggcg accaccgcac tgcctgcaac cagcgccacc agctgcaaga
    17761 cctccatcga agatcccatc cgtgttcgtc ggagccgtgc gcacccgcac cctggccgta
    17821 cgctggccat catgagcgag tgcacccacg ttgccgaact gccgcgcccc gagcccatcc
    17881 cctctgccca gacctgcacc gaatgtctgg cgctcggcag ccaccccgtg cagctgcgga
    17941 tgtgtctggg atgcgggtac gtggcctgct gcgactcctc cccgtaccgg cacgcgacgg
    18001 cgcaccacaa ggacaccggc catccggtga tgcggagctt cgagccgggc gagatctggc
    18061 gctggtgttt tgtcgacggt tcgatcgtct gaggaggggt aggtcaaccc tccgccggtt
    18121 cccccgattt ggacccgcag acccctagcc actgtgcgta cccatgggct taccatcagt
    18181 cactggccgt gggaaggggt gcccccagcg ggcgccacga ggggtgccgc gacacgatcg
    18241 cccggatcgc gatagcgtca ccggcgaaca cagctcgtac caccttggag gtgagggtgt
    18301 cccagatcgc aggcgagccc gggacccagg acttcgtgga agtccggctg cccgctgcgg
    18361 gtgcctacct gtcggtgctg cggacggcca cggccggcct cgcagcacgt ttggacttca
    18421 ccctcgacga gatcgaggac ctccgcatcg cggtggacga ggcctgcgcg atcctgctcc
    18481 agcaggccgt gcccggctcc gtcctcagct gcgtcttccg gctggtggac gattcgctgg
    18541 aggtgaccgt ctcggcgccg accacggacg gccgtgcgcc ggagcgcgac acgttcgcct
    18601 ggaccgtact gtcggcgctg gccggcaagg tcgagtcgac ggtcgaggag gaccggacgg
    18661 tgagcatcag tctctacaaa cagcgcggcg cgggaccagg cccggcgtga gcggcgggga
    18721 gatcccggtg cggggcgggg atcggccccg ggtgcggcac gaggtcgacg gcagcatccc
    18781 ggagcagcag cacgcccggc cgcacccggc tgacacggat gcggaagacg gctttttgga
    18841 ctcggcggag cgacgggcgg gccctatgag cgacaaccag cacgaagaac cacagccggc
    18901 acagccaccg gcggccgctg ccacggcccc ggaggttccg gtgcctccgg aagtgccggt
    18961 actcccggag gtgcccgcgt tccagccgac cgcgccactg ccggatccgc gcgaccgcag
    19021 cggggcgcgc gccctgttca tcgagctgcg ggcactgccc gacggctcgg tggagaaggc
    19081 cgagctgcgc aaccggctcg tacggatgca cctgccgctg gtcgagcacc tggcacggcg
    19141 gttccgcaac cgcggcgagc cgctcgacga cctgacgcag gtcgcgacca tcggcctgat
    19201 caagtcggtg gaccggttcg acccggaccg cggggtcgag ttctccacgt acgccacgcc
    19261 cacggtggtc ggcgagatca agcgccactt ccgtgacaag ggctgggcgg tacgggtgcc
    19321 ccggcgtctg caggagctgc ggctctcgct gacgacggcc accgccgaac tgtcccagca
    19381 gcacggccgc tcccccacgg tgcacgaact ggccgaacgg ctggggatct ccgaggagga
    19441 ggtgctggag gggctggaat cggccaatgc ctacagcacg ctgtcgctgg acgtcccgga
    19501 caccgacgat gagtcgccgg cggtcgcgga caccctgggc tcggaggacg aggccctgga
    19561 gggcgtcgag taccgagagt ccctcaagcc gctgctggag ggcctgccgc cgcgggagaa
    19621 gcggatcctg ctgcttcggt tcttcgggaa catgacccag tcgcagatcg cccaggaggt
    19681 cggcatctcc cagatgcacg tctcccgtct gctggcccgc accctggccc agctgcgcga
    19741 gaagctcctc gtcgaggagt agccggtcga ggagcaacca ggagccgccg gactatcggg
    19801 cctgttcgcc gggcccgata cccagggcct cggtcgccgt cggattgacc agcagggccg
    19861 cgaccgccac cgcggccacg cccagggcca ccgcggcggc gatcatcgca ccgccggtgc
    19921 tgtacagagt ccaggccacc ggcagcgcca tcagctgggt gatcagcgcc gggccgcggc
    19981 tccagcggcg gcccaggcgc agaccgcggg ccgcgatcag cggcagcgcg gcgagcgcga
    20041 gcagggtgat gccgcccgtc tccgcctgct gcggggagtc gggatcgccg gcgatgccca
    20101 cgaacagcat gtagacaccg aggccggcca gcgccaggcc ctccagggcg gtcagcgcgg
    20161 cggcggcggt cagccggccc ggcagcgcgg cggcgggagt ggtggcgggg gcggcggcat
    20221 tcgcgggctg cttcttactc actccagcag ggtagccgcg tgccccggag gccggagggg
    20281 acggggcagc agggtcgcca ttcgaagctc atggacgggc tgggtagtct ggcgctcatg
    20341 cgtgcacttc tcgtggccaa cccagcagcg acgaccacca gtgcgcgcac gcgtgacgtc
    20401 ctgacccacg ccttggccag cgagatgaag ctggaggcgg tgaccaccga gtaccggggc
    20461 cacgcccggg acctgggacg ccgggccgcg cacgaagggc tcgacctcgt cgtggccctg
    20521 ggcggcgacg gcaccgtcaa cgaggtggtc aacgggctgc tgcacgacgg gcccgatccg
    20581 gaccggctgc cccggctggc cgtggtcccc ggcggctcca ccaatgtctt cgcccgcgca
    20641 ctcggcctgc ccaacgatgc ggtcgaggcg accggcgccc tgctggacgc actgcgggag
    20701 cagcgcgagc ggatcgtggg cctgggtctg gcggccggca ccccgggcac ggaggacgag
    20761 tcggtcccgg cgcgctggtt caccttctgc gcgggcttcg gtttcgacgc gggcgtggtg
    20821 gggcgggtcg agcagcagcg cgagcgcggc aagcgttcga cgcacgctct gtatgtacga
    20881 cagctgatgc gtcagttctg ggacgagccg aaccgccggc acggcacggt cacgctggag
    20941 cgctccggcg ccgatccggt gacggatctg gtgctgtcga tagtctgcaa cacctcgccg
    21001 tggacgtatc tgggcaatcg tccgctttac gcctccccgg aggcgtcgtt cgatacagcg
    21061 cttgacgtac tggc
//
