LOCUS       NZ_CP102509            20786 bp    DNA     linear   CON 06-JAN-2024
DEFINITION  Streptomyces sp. NBC_00162 chromosome, complete genome.
ACCESSION   NZ_CP102509
VERSION     NZ_CP102509.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NBC_00162
  ORGANISM  Streptomyces sp. NBC_00162
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8635149)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Joergensen,T.S., Klitgaard,A.,
            Mourched,A.-S., Blin,K., Larsen,T.O., Weber,T., Gotfredsen,C.H. and
            Charusanti,P.
  TITLE     Identification of the biosynthetic gene cluster for pyracrimycin A
            and elucidation of a key reaction during its biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8635149)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/05/2024 18:03:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,275
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,805
            CDSs (with protein)               :: 7,805
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 371
            CDSs (without protein)            :: 370
            Pseudo Genes (ambiguous residues) :: 0 of 371
            Pseudo Genes (frameshifted)       :: 186 of 371
            Pseudo Genes (incomplete)         :: 231 of 371
            Pseudo Genes (internal stop)      :: 27 of 371
            Pseudo Genes (multiple problems)  :: 68 of 371
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:41:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3133954
            Orig. end                         :: 3154740
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20786
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="23"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20786
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20786
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10786](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10786
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            complement(266..1000)
                     /locus_tag="JIW86_RS14345"
                     /old_locus_tag="JIW86_14345"
     CDS             complement(266..1000)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743374.1"
                     /locus_tag="JIW86_RS14345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14345"
                     /product="enhanced serine sensitivity protein SseB"
                     /protein_id="WP_257554058.1"
                     /transl_table=11
                     /translation="MQGGGWPGNELEQVLGAALGQPDAGGRILEVLGRSMVWVPLPGGG
                     APDAESLDLPTMDIGGAAYVPVYSSEAQFRYCVGPGMDFAVAPAVEFARGLPPQLGIAL
                     NPEGAVGVPLPPQAVAELCRTGRTPLDGPSTGGRVRLYEPDWQEDPVDFLAAAAEEFRT
                     AGVVTAAYRCLASVEGGEPELFIGVRLVGWEPEMRNAPMEALGRALARVPAPWPVQLIL
                     LDAAQDPVTDWIRERVRPFYLP"
     gene            complement(1170..1787)
                     /locus_tag="JIW86_RS14350"
                     /old_locus_tag="JIW86_14350"
     CDS             complement(1170..1787)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127743.1"
                     /locus_tag="JIW86_RS14350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14350"
                     /product="AAA family ATPase"
                     /protein_id="WP_257559318.1"
                     /transl_table=11
                     /translation="MDAVPAQRGACAGPGRVRDLRGAGARGARRLGFAQGDIVVVSGLP
                     GGGKSTLIKRAAGEGGAIDSQDTRERWERRMPGGLPYGVYRPLVRAAHYWGLWRTLRSG
                     ASVVVHDCGTQAWVRGLLAAAARRRGRALHLLLLDSSPEEALSGQAARGRRVTAYAFAR
                     HRGAVTRLLREAEAGRPPAGCASVTLLDRPSAAAVARITFHS"
     regulatory      2011..2114
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            2272..3387
                     /gene="gcvT"
                     /locus_tag="JIW86_RS14355"
                     /old_locus_tag="JIW86_14355"
     CDS             2272..3387
                     /EC_number="2.1.2.10"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004047 - aminomethyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /gene="gcvT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018509776.1"
                     /locus_tag="JIW86_RS14355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14355"
                     /product="glycine cleavage system aminomethyltransferase
                     GcvT"
                     /protein_id="WP_215140183.1"
                     /transl_table=11
                     /translation="MSTAPRLTALDALHRSLGATMTDFAGWDMPLRYGSERDEHNAVRT
                     KAGLFDLSHMGEITLTGPEAVKVLDYALVGNISTVGVGRARYTHICQEDGGIVDDLIVY
                     RLGETEFMVVANASNAQVVLDALTERAAGFDAEVRDDRDAYALIAVQGPESPGILASLT
                     DADLDGLKYYAGLPGTVAGVPALIARTGYTGEDGFELFVAPEHAVELWQALTKAGEGVG
                     LVPAGLSCRDTLRLEAGMPLYGHELTTSLTPFDAGLGRVVKFEKEGDFVGRAALEAAAE
                     RAASNPPRKLVGLIAEGRRVPRAGFPVVADGQVIGEVTSGAPSPTLGKPIAMAYVDAAH
                     AAPGTSGVGVDIRGTHEPYEVVALPFYKRQK"
     gene            3477..3857
                     /gene="gcvH"
                     /locus_tag="JIW86_RS14360"
                     /old_locus_tag="JIW86_14360"
     CDS             3477..3857
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /gene="gcvH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743370.1"
                     /locus_tag="JIW86_RS14360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14360"
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="WP_215140184.1"
                     /transl_table=11
                     /translation="MSNPQQLRYSKEHEWLSDAEGGVATVGITEFAANALGDVVYAQLP
                     EVGDTVTAGETCGELESTKSVSDLYSPVSGEVVESNQDVVDDPALVNTAPFEGGWLFKV
                     RVAEEPADLLSADEYAKLTAGN"
     gene            3873..5129
                     /gene="glyA"
                     /locus_tag="JIW86_RS14365"
                     /old_locus_tag="JIW86_14365"
     CDS             3873..5129
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (77-366). E-value:
                     2.9e-11. Score: 35.0. Matches aSDomain:
                     nrpspksdomains_JIW86_RS14365_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="glyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311636.1"
                     /locus_tag="JIW86_RS14365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14365"
                     /product="serine hydroxymethyltransferase"
                     /protein_id="WP_257554059.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.1e-09, bitscore:
                     34.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLNTPLHELDPDVAAAVDAELVRQQSTLEMIASENFAPVAVME
                     AQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRIKALFGAEAANVQPHSGAQANAA
                     AMFALLKPGDTIMGLNLAHGGHLTHGMKINFSGKLYNVVPYHVDETGRVDMAEVERLAK
                     ESRPQLIVAGWSAYPRQLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHV
                     VTTTTHKTLGGPRGGVILSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFLVAASEDF
                     KERQVRTLEGAKIIAERLVQPDVTEVGVSVLSGGTDVHLVLVDLRNSELDGQQAEDRLH
                     EIGITVNRNAIPNDPRPPMVTSGLRIGTPALATRGFGAEDFKEVAEIIAAALKPAYDSE
                     SLKARVTALAAKFPLYPSL"
     aSDomain        4104..4970
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS14365_Aminotran_1_2.1"
                     /evalue="2.90E-11"
                     /label="JIW86_RS14365_Aminotran_1_2.1"
                     /locus_tag="JIW86_RS14365"
                     /protein_end="366"
                     /protein_start="77"
                     /score="35.0"
                     /tool="antismash"
                     /translation="AIDRIKALFGAEAANVQPHSGAQANAAAMFALLKPGDTIMGLNLA
                     HGGHLTHGMKINFSGKLYNVVPYHVDETGRVDMAEVERLAKESRPQLIVAGWSAYPRQL
                     DFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHVVTTTTHKTLGGPRGGVIL
                     STQELAKKINSAVFPGQQGGPLEHVIAAKAVSFLVAASEDFKERQVRTLEGAKIIAERL
                     VQPDVTEVGVSVLSGGTDVHLVLVDLRNSELDGQQAEDRLHEIGITVNRNAIPNDPRPP
                     MVTSGLRI"
     gene            5395..6777
                     /locus_tag="JIW86_RS14370"
                     /old_locus_tag="JIW86_14370"
     CDS             5395..6777
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009063 - amino acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889625.1"
                     /locus_tag="JIW86_RS14370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14370"
                     /product="L-serine ammonia-lyase"
                     /protein_id="WP_257554060.1"
                     /transl_table=11
                     /translation="MAISVFDLFSIGIGPSSSHTVGPMRAARMFVTRLKKDGVLAQTAS
                     VRAELFGSLGATGHGHGTPKAVLLGLEGHSPRTVNVETADDEVERIRKSGRLRLLGAEI
                     GDGHEIAFDEPNQLILHRRRSLPYHANGMTLFAYDAAGAPLLEKTYYSVGGGFVVDEDA
                     VGEDRIKLDDTVLKYPFRSGDEMLRLANETGLSISSLMLENEKAWRTEDEIREGLLEIW
                     RVMQSCVSRGMSREGILPGGLRVKRRAASTARQLRTEGDPMMHRSEWTTIYAMAVNEEN
                     AAGGRVVTAPTNGAAGVLPAVLHYYVNFVPGADEDGVVRFLLAAGAIGMLFKENASISG
                     AEVGCQGEVGSACSMAAGALAEVLGGTPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCI
                     ERNGMAAVKAVTAAKMAMRGDGTHKVSLDKVIKTMKETGADMKVKYKETARGGLAVNVI
                     EC"
     gene            6933..7466
                     /locus_tag="JIW86_RS14375"
                     /old_locus_tag="JIW86_14375"
     CDS             6933..7466
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891460.1"
                     /locus_tag="JIW86_RS14375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14375"
                     /product="hypothetical protein"
                     /protein_id="WP_257554061.1"
                     /transl_table=11
                     /translation="MIHPLRPHRRRIVALASGILLTAGLSLAAPASAAGITATRTETQP
                     QTPLVVNARWGGHATYDRIVIDLQGFVPGVTVTAVPRLIQDGSGKPVPLAGNYFLEIRL
                     NPAAAHNDAGESVYHGPTLQKIYLSKLKGLAKTGDFEGYVTFGAAFDTVPYYRTFALHS
                     PERFVVDIAHANQC"
     gene            complement(7506..7925)
                     /locus_tag="JIW86_RS14380"
                     /old_locus_tag="JIW86_14380"
     CDS             complement(7506..7925)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JIW86_RS14380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JIW86_14380"
                     /product="hypothetical protein"
                     /protein_id="WP_257554062.1"
                     /transl_table=11
                     /translation="MAMDRMFKDGCPFDDRDADWAAYTLVPKIGDMVKAVAGARGTDYL
                     DLRDALAGHEVCSLGTEQVGQGGPDPREHEWFRFLYYVNTQGTLDESMHPNAHGQRATA
                     ACLGLVAAAAPGRRSCTQDWFGDGDPGRMRIRPAA"
     misc_feature    7903..7918
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            complement(8094..8843)
                     /locus_tag="JIW86_RS14385"
                     /old_locus_tag="JIW86_14385"
     CDS             complement(8094..8843)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677015.1"
                     /locus_tag="JIW86_RS14385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14385"
                     /product="flavodoxin family protein"
                     /protein_id="WP_257554063.1"
                     /transl_table=11
                     /translation="MAAAPPPAEAGTVAADYDYSDLTAVYVNCTLKRSPETSNTEGLID
                     KSRAVMTAAGVRTSLIRAVDHDIATGVWPDMTEHGWESDQWPVLYSQIMDADILVLCGP
                     IWLGDNSSVMKQVIERLYACSSVLNDRGQYAYYGRVGGALITGNEDGVKHCAMNILYSL
                     QHLGYTIPPQADAGWIGEAGPGPSYLDAGSGGPENDFTNRNTAFMSWNLMHLATLLKRS
                     GGVPAHGNQRSLWDAGCRFDFPNPEHR"
     gene            8918..9478
                     /locus_tag="JIW86_RS14390"
                     /old_locus_tag="JIW86_14390"
     CDS             8918..9478
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884089.1"
                     /locus_tag="JIW86_RS14390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14390"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_257554065.1"
                     /transl_table=11
                     /translation="MSLPHAILTALLEKPSSGLELTRRFDRSIGYFWSATHQQIYRELG
                     RLEESGLIRALPSEVPVRGQKKEYEVLAAGSAELARWVGESQDPKPMRDPLLLRIRAAG
                     VVGPQGLGPELRRHLELHRRQLAQYGAIEEKDFPPERDAVEDRLRRLVLHGGIALEMFW
                     LHWLEEALAEVEDMTAGGPGSGA"
     gene            complement(9534..9746)
                     /locus_tag="JIW86_RS14395"
                     /old_locus_tag="JIW86_14395"
     CDS             complement(9534..9746)
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266682.1"
                     /locus_tag="JIW86_RS14395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14395"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_215140193.1"
                     /transl_table=11
                     /translation="MADIESARATFNKFDVNGDGFITADEYSAAMKAMGDAYVTGAVAD
                     AVLAAKDANGDGLLSFDEFWAALNK"
     misc_feature    9904..9917
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.0"
                     /tool="antismash"
     gene            10001..10786
                     /locus_tag="JIW86_RS14400"
                     /old_locus_tag="JIW86_14400"
     CDS             10001..10786
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889609.1"
                     /locus_tag="JIW86_RS14400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14400"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_257554066.1"
                     /sec_met_domain="CDPS (E-value: 2.3e-83, bitscore: 278.0,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITADASFEVLPFTRTCRHIWEDGDHVLIGVSPGNSYFSSERIS
                     SLAQWATTRFAQVDFVYADLHVDRMFAAFGYTREHAEKRATKEIKAVRRRILKGVEESG
                     PPQAEIRVRALSEFQENPVYQLLHRRVLHFLATDDEFRKGCEKMALHFVGSKLPEGESI
                     TDAQLQVCFDYMAAELPFFVDTPSILDVPSSVAAYHVKMPLTDVLFARGGGLRATRNQA
                     YAVVRPEAAAAERPPVSGTAGNHVDHAPTERTVDERRAA"
     gene            10767..12008
                     /locus_tag="JIW86_RS14405"
                     /old_locus_tag="JIW86_14405"
     CDS             10767..12008
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999282.1"
                     /locus_tag="JIW86_RS14405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14405"
                     /product="cytochrome P450"
                     /protein_id="WP_215140195.1"
                     /sec_met_domain="p450 (E-value: 6.1e-13, bitscore: 47.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVEQLEGREGRERQPLLDFPLSRRGDVLPEECGWLREKAPVAKV
                     RTLTGDPAWLVSSYALAKQVLEDERFSLKDTANAGVPRQYALTIPPEVVNNMGNINSAG
                     LRNAVMKALNPRQKGLQDRLRATAGELIDQLVAEGGPADLRAGFADPFSAALHCQVLGV
                     PFEDWRRLMSGLDVAFMTAREPFADSALNWYKDVGYFAEQLNVQLALPAEERTGLLGRF
                     AGLKEADPESAHLTDDMFATVAVSLFGAGAVSTSAFLVLAVLALLQRPELIGYLRKHPE
                     RMGKAVDELLRWNLSVGDGLPRIALADIQVGDVLVKEGELVLVLLEGANFDPEAFENPD
                     ELNLERESPNAHLAFGAGRHFCPASALGRAHAEIALEVLVERLSGLRLAVPAENLVWRT
                     GFIKRLPERLPVAW"
     gene            complement(12068..13255)
                     /locus_tag="JIW86_RS14410"
                     /old_locus_tag="JIW86_14410"
     CDS             complement(12068..13255)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743359.1"
                     /locus_tag="JIW86_RS14410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14410"
                     /product="YncE family protein"
                     /protein_id="WP_257554067.1"
                     /transl_table=11
                     /translation="MKTTCLPRKAAVLLAGLVLAALAGCGSADKGPAEALGTKGPAQPP
                     KAVPAAPPGLAGMPPLLDPNDVYAADRPNKLSPVVKDFPSRVYVPNTNSNTVSVIDPVT
                     YQVIDTIPVGVQPQHVVPSWDLKTLWVNNNRGHTLTPINPATGEAGQPVEVHDPYNLYF
                     TPNGKYAIVMASMDKELVFRDPHTMDRVKTVPVTCYGVNHADFSADGRYFIVSCEFSGE
                     LLKVDTEKMEVIGQQKLPFEGAMPQDVKVSPDGKTFYVADMMAHGMWVLSGDTFEVPKL
                     LPTGKGCHGLYVSRDSKEMYVSNRGEGTISVFNFPQNKLTKKWTLPDGGSPDMGGVSAD
                     GKVLWLSGRYNSEVYAIDTATGKELARIPVGGGPHGLAVYPQPGRYSLGHTGIFR"
     gene            complement(13252..13983)
                     /locus_tag="JIW86_RS14415"
                     /old_locus_tag="JIW86_14415"
     CDS             complement(13252..13983)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266680.1"
                     /locus_tag="JIW86_RS14415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14415"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_257559319.1"
                     /transl_table=11
                     /translation="MAGLTAACGSGRPATSPSAAPPGPARPARPAEAAPAVPRRYPGQP
                     VEIAHGPRDRPRVALTFHGNGEPAIARAVLAEAERAGARVTVLAIGGWLDAHPDLARRI
                     LDGGHDLGNHTQRHLAINDMPEAEAYAEITGCAQRLKRLTGSIGTWFRPSQAQYATPLV
                     RKLAQRAGYPHVLSYDVDSLDFTSPGAAAVTRTVTGTIRPGSVVSLHFGYADTVDAMPP
                     LLEELARRKLRAVTTTELLTP"
     misc_feature    14051..14067
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.23"
                     /tool="antismash"
     gene            complement(14416..14928)
                     /locus_tag="JIW86_RS14420"
                     /old_locus_tag="JIW86_14420"
     CDS             complement(14416..14928)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127688.1"
                     /locus_tag="JIW86_RS14420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14420"
                     /product="ATP-binding protein"
                     /protein_id="WP_215140198.1"
                     /transl_table=11
                     /translation="MAGLEGVEQPRQRSSASAVRLTAAIEDEQGLKALELYGNPAEAEV
                     ILPSMPESAGTARRLTQCVVIRLWGLSPQISEHAVLLVSELVGNAVRHTGARSFGLRML
                     RRRGWIRVEVRDPSRGLPCLMPVHELDTTGRGLFLVDKLSDRWGADLLPRGKITWFEMR
                     VADRQNA"
     misc_feature    complement(14626..14628)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14943..14957
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     gene            complement(15186..15953)
                     /locus_tag="JIW86_RS14425"
                     /old_locus_tag="JIW86_14425"
     CDS             complement(15186..15953)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (5-246). E-value: 4.8e-76. Score:
                     247.2. Matches aSDomain:
                     nrpspksdomains_JIW86_RS14425_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432556.1"
                     /locus_tag="JIW86_RS14425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14425"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_257554068.1"
                     /transl_table=11
                     /translation="MTISLEVSEGVGTIRLDRPPMNALDIATQDRLRELAVEATDRDDV
                     RAVIIYGGEKVFAAGADIKEMQAMDHAAMIARSRALQDSFTAVARIPKPVVAAVTGYAL
                     GGGCELALCADYRIAADNAKLGQPEILLGLIPGAGGTQRLSRLIGPSKAKDLIFTGRMV
                     KADEALALGLVDRVVPAAEVYEQAHAWAAKLAQGPAIALRAAKECVDAGLEADIDTGLT
                     IERNWFAGLFATEDRERGMRSFVEEGPGKAKFV"
     aSDomain        complement(15216..15938)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS14425_ECH.1"
                     /evalue="4.80E-76"
                     /label="JIW86_RS14425_ECH.1"
                     /locus_tag="JIW86_RS14425"
                     /protein_end="246"
                     /protein_start="5"
                     /score="247.2"
                     /tool="antismash"
                     /translation="EVSEGVGTIRLDRPPMNALDIATQDRLRELAVEATDRDDVRAVII
                     YGGEKVFAAGADIKEMQAMDHAAMIARSRALQDSFTAVARIPKPVVAAVTGYALGGGCE
                     LALCADYRIAADNAKLGQPEILLGLIPGAGGTQRLSRLIGPSKAKDLIFTGRMVKADEA
                     LALGLVDRVVPAAEVYEQAHAWAAKLAQGPAIALRAAKECVDAGLEADIDTGLTIERNW
                     FAGLFATEDRERGMRSFVE"
     gene            complement(16040..17263)
                     /locus_tag="JIW86_RS14430"
                     /old_locus_tag="JIW86_14430"
     CDS             complement(16040..17263)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266677.1"
                     /locus_tag="JIW86_RS14430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14430"
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_257559320.1"
                     /transl_table=11
                     /translation="MQPIRGRVRTGLPALLLGAALLLTTACSGGGGGNNGSGSGGDNAG
                     GGAKNGTEASKAVVSVKPDDGAKEVATSGILKITSTGGKLTTVTVADTKGNAVEGKLAD
                     DGASWEPSRHLASATEYKVHAVAKDEAGRESAKDTTFTTLTPTNTFIGHYTPEDGSTVG
                     VGMPVSINFTRGITNPEAVEKAITVTAEPAVPVEGHWFGNDRLDFRPEKYWAAGTKVTV
                     KLALDGVEGRPGVYGKQTRTVTFTVGRSQVSTVDASEHTMEVVRDGQVLKNIPITAGAP
                     STTTYNGQMVISEKYKVTRMNGATVGFGGEYDISDVPHAMRLSNSGTFVHGNYWASSGT
                     FGSENVSHGCVGLKDVRGAGDGNQPAAWFFNESLIGDVVIVKNSKDKQISPDNGLNGWN
                     MDWAEWIK"
     misc_feature    17315..17331
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.23"
                     /tool="antismash"
     misc_feature    17359..17374
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(17389..18609)
                     /locus_tag="JIW86_RS14435"
                     /old_locus_tag="JIW86_14435"
     CDS             complement(17389..18609)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266675.1"
                     /locus_tag="JIW86_RS14435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_14435"
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_257559322.1"
                     /transl_table=11
                     /translation="MTRRAGAGLAAVAAWAGLLGGLAGCTQDGRSPVEIELPGKPRSPD
                     EAIRITPDDNAKGVPAGGRLSVTVPEGRLERVVVTKVEDAQEEKVPGAIAEDGLSWSPD
                     PEAARLSLAAKYTVDAVALDGHDRRQARHTTFTTYVPEERFIGYFKPENRSTVGTGMIV
                     SFNFNRAIARRAEVERAITVTSNPPVEIVGHWFGKERLDFRPKEYWKSGTEVTVKMNLR
                     DIEGAPGSYGIQAKTITFTVGRSQISTVDAAAHTMEIRRDGRLLQTLPITAGAPKTTTY
                     NGKMVVMELFDVTRMNGQTVGFGGEYDIPDVPHAMRLTSSGTFLHGNYWASPDTFGSAN
                     VSHGCVGLRDDKGGGSDTPAGWFFDRSLVGDVVEILNSQDKTVAPNNGLGGWNMSWADW
                     VAGSAIA"
ORIGIN
        1 gaggtcacgc agggcgcgta gccgaggctc tcgacctcca tgccgccgta ctgggcatcg
       61 ggggaacccg gctgcccctg ccagagcagc atccacagcc ggccctcgga aagggcatgc
      121 agaagtgact cgtagctctc atagcgcccg ggagtcacct ggcgcagcat gtgctcgacc
      181 tgcccggccg cggccgtgcc tgacgcactc acccggtacc cctcttcgtc cgcccgtcgt
      241 ccacgcgtac ccagcttaag cggccctacg ggaggtagaa ggggcgtacg cgctcacgaa
      301 tccagtccgt gaccgggtcc tgggcggcgt ccaggagaat caactgcacg ggccagggcg
      361 ccgggacccg ggccagggcc cggccgaggg cctccatcgg ggcattccgc atctcaggct
      421 cccatcccac caggcggaca ccgatgaaca gttccggttc cccgccctcg acgctggcga
      481 ggcagcggta ggcggccgtg accacaccgg cggtacggaa ctcctcggcc gcggcggcca
      541 ggaagtccac cgggtcctcc tgccagtcgg gctcgtagag ccggacccga ccgccggtgg
      601 acgggccgtc gagcggggtc cgcccggtgc ggcaaagctc cgcgacggcc tgcgggggca
      661 gggggacgcc gacggcgccc tcggggttga gggcgatgcc gagctgcggg ggcaggccgc
      721 gggcgaactc gacggcgggg gccacggcga agtccatgcc ggggccgacg cagtagcgga
      781 actgggcctc ggagctgtag acggggacgt acgccgcccc gccgatgtcc atggtgggca
      841 ggtcgaggct ctcggcgtcc ggggcgccgc cgccgggcag gggcacccag accatgctgc
      901 gtccgagcac ctccaggatc cgccccccgg catccggctg cccgagcgcc gccccgagca
      961 cctgctccag ctcattcccc ggccagccgc cgccttgcat gtgcccctgc ctccgtcttg
     1021 ggtcccgccg atgtcgtgcc cgaggttatc ggtgcgggtc cgctgctcgg gctccgcccc
     1081 agagctcgcg cctcaaacgc cggcggggct ggatctggcc ggcgtaagcc tcaaagcgca
     1141 ctgcccggtc ttgagcccgg caacggcgat cagctgtgga acgtgatgcg ggcgacggcg
     1201 gcagccgagg ggcggtccag gagggtgacc gaggcgcagc ccgccggggg gcggccggct
     1261 tccgcttcgc gcagcaggcg ggtcaccgca ccccggtggc gggcgaaggc gtacgccgtc
     1321 acccggcgcc cccgcgccgc ctggccggac agcgcctcct ccgggctgct gtccaggagc
     1381 agcaggtgca gcgcccggcc ccggcggcgc gcggccgccg cgagcaggcc ccgtacccag
     1441 gcctgggtac cgcagtcgtg gacgaccacc gaggctccgg agcgcagggt ccgccacagc
     1501 ccccagtagt gcgcggcccg caccagcggc cggtacaccc cgtacggcag cccgcccggc
     1561 atccgccgct cccagcgctc tcgcgtgtcc tgggagtcga tcgcgccgcc ctcgccggcc
     1621 gccctcttga tcagcgtgct cttgccgccg cccggcaggc cggacaccac gacgatgtcc
     1681 ccctgcgcga agccgagccg gcgcgccccc cgcgccccgg ccccgcgcag gtcacgtacc
     1741 cgcccggggc cggcgcaggc accgcgctgc gccggcaccg cgtccacggt ccccgtagcc
     1801 gccactactc cgaatctccg cacagtgttc gcctcccccg aatcgggtca ccaggaccct
     1861 tgcccactga gtgtaaagag acggtaatcc ggcagccccg gttccggtcc gccctcccgg
     1921 tccccgtacc aactttcggg gccccacacc cgatcaccac ggtggcgtgc aatgatgtgc
     1981 gccatctgga ccaactgcat accggccgct tgaatccgcg cgggagagtc ccggcacgcc
     2041 gcaaggccgt gctcgggcgc cgaaggagca agaacctccc ttgaatctct caggccccgt
     2101 accgcgtgga tgaggcagat ctgaaaagcg agctgttcga cagctccacc caaggtgcaa
     2161 gccgacgatc cctggcaacc ggggcactct cggcgaacct ctcaggttcc gatgacagat
     2221 ggggaggacc ctcctcgtca tgtcatgccc tgggactcgg gagccacacc catgagcact
     2281 gccccccgtc tgaccgccct cgatgcgctg caccgctcgc tcggtgcgac catgaccgac
     2341 ttcgcgggct gggacatgcc cctgcggtac ggcagtgagc gcgacgagca caacgccgta
     2401 cgcaccaagg ccggtctctt cgatctgtcc cacatgggcg agatcaccct gaccggcccg
     2461 gaggccgtca aggttctgga ctacgcgctg gtcggcaaca tctcgaccgt cggcgtcggc
     2521 cgtgcccgct acacgcacat ctgccaggaa gacggcggga tcgtcgacga cctgatcgtc
     2581 taccgcctcg gtgagaccga gttcatggtc gtcgccaacg cctccaacgc ccaggtagtc
     2641 ctggacgccc tgaccgagcg cgccgccggc ttcgacgccg aggtccgcga cgaccgcgac
     2701 gcgtacgcgc tgatcgccgt ccagggtccg gagtcccccg gcatcctcgc ctcgctcacc
     2761 gacgccgacc tggacgggct caagtactac gccggtctgc cgggcacggt ggccggggtc
     2821 cccgcgctga tcgcccgtac gggctacacc ggcgaggacg gcttcgagct gttcgtcgcc
     2881 cccgagcacg ccgtggagct gtggcaggcg ctgaccaagg cgggcgaggg cgtcggcctg
     2941 gtcccggccg gtctgtcctg ccgcgacacc ctgcgcctgg aggcgggcat gccgctgtac
     3001 gggcacgagc tgaccacctc gctcaccccc ttcgacgcgg ggctgggccg ggtcgtgaag
     3061 ttcgagaagg agggggactt cgtcggccgt gccgcgctgg aggccgccgc cgagcgcgcc
     3121 gcctcgaacc cgccgcgcaa gctggtcggc ctgatcgccg agggccgccg cgtcccgcgc
     3181 gccggtttcc ccgtcgtggc ggacggccag gtcatcggcg aggtcacctc gggcgccccg
     3241 tcgccgacgc tgggcaagcc gatcgcgatg gcgtacgtcg acgcggcgca cgccgcgccc
     3301 ggcacctccg gtgtcggcgt ggacattcgc ggtacgcatg agccgtacga ggtcgtggcc
     3361 ctgccgttct acaagcggca gaagtaaccc tcgtaagccg tctccgcagt accggccgtc
     3421 tcagtaccca agaccgctgt tcgtatccac tcccccgcat ccaggagaat caggtcatga
     3481 gcaaccccca gcagctgcgt tacagcaagg agcacgagtg gctgtcggac gccgagggcg
     3541 gcgtcgcgac ggtcggcatc acggagttcg cggccaacgc gctcggtgac gtcgtctacg
     3601 cccagctccc cgaggtaggc gacacggtga ccgcgggtga gacctgcggc gagctggagt
     3661 cgaccaagtc ggtcagcgac ctgtactccc ccgtctccgg cgaggtcgtc gagtccaacc
     3721 aggacgtcgt ggacgacccg gccctcgtga acaccgcgcc gttcgagggt ggctggctgt
     3781 tcaaggtgcg cgtcgcggag gagccggccg acctgctctc cgctgacgag tacgccaagc
     3841 tcaccgccgg taactgaccc caggggatcc tgatgtccgt actgaacacc cctctccacg
     3901 aactcgaccc cgacgtcgcc gccgccgtcg acgccgagct cgtgcgccag cagtcgaccc
     3961 tggaaatgat cgcgtcggag aacttcgctc cggtcgccgt catggaggcc cagggctcgg
     4021 tcctgaccaa caagtacgcc gagggctacc ccggccgccg ctactacggc ggctgcgagc
     4081 acgtcgacgt ggtcgagcag atcgcgatcg accgcatcaa ggcgctcttc ggcgccgagg
     4141 ccgcgaacgt ccagccgcac tcgggtgcgc aggcgaacgc cgccgcgatg ttcgcgctgc
     4201 tgaagccggg cgacacgatc atgggtctga acctggccca cggcggtcac ctgacccacg
     4261 gcatgaagat caacttctcc ggcaagctct acaacgtggt cccgtaccac gtcgacgaga
     4321 ccggccgcgt ggacatggcc gaggtcgagc gcctcgccaa ggagtcccgc ccgcagctga
     4381 tcgtcgcggg ttggtccgcc tacccgcgcc agctggactt cgccgccttc cgccgcatcg
     4441 cggacgaggt cggcgcgtac ctgatggtcg acatggcgca cttcgccggc ctggtcgccg
     4501 cgggcctgca cccgaacccg gtgccgcacg cccacgtcgt caccaccacc acgcacaaga
     4561 ccctcggcgg tccgcgcggc ggtgtgatcc tgtcgacgca ggagctggcc aagaagatca
     4621 actccgcggt cttccccggc cagcagggcg gcccgctgga gcacgtgatc gccgccaagg
     4681 cggtctcctt cctcgtcgcc gcctcggagg acttcaagga gcgccaggtg cgcaccctcg
     4741 agggcgcgaa gatcatcgcc gagcgcctgg tgcagccgga cgtcaccgag gtcggcgtct
     4801 ccgtcctctc cggcggtacg gacgtccacc tggtcctggt cgacctgcgc aactccgagc
     4861 tggacggcca gcaggccgag gaccggctcc acgagatcgg catcacggtc aaccggaacg
     4921 ccatcccgaa cgacccgcgg ccgccgatgg tcacctcggg tctgcggatc ggcaccccgg
     4981 cgctcgccac ccgcggtttc ggcgccgagg acttcaagga ggtcgcggag atcatcgcgg
     5041 ccgcgctgaa gccggcgtac gacagcgagt ccctcaaggc ccgcgtcacc gcgctcgccg
     5101 cgaagttccc gctgtacccg tcgctctgag caacggctag ggggcccggc cttgtcttgc
     5161 acagggccgg gcctttctca tgaccgcgtc atcctccccc ggggacttcg ccctggtggc
     5221 ggcccctgcg gcgcgtgggc cgacacccgc ccgaccccgt ctcgaccacg ccccgacccc
     5281 gtccggcaga cgagccgttc atttcgccgc gttaagctcg tctctcggac aaaatccgaa
     5341 caatccacca ctcctgcccc ctcccacccc acgagcagac aagggagtcc gccagtggcc
     5401 atctccgtct tcgatctctt ctccatcggc atcggcccgt cctcctccca cacggtcggt
     5461 ccgatgcgcg ccgcacgcat gttcgtgacg cggctgaaga aggacggtgt gctcgcccag
     5521 accgcgtccg tgcgcgccga gctcttcggc tccctcggcg cgacgggcca cggccacggc
     5581 acgcccaagg cggtactgct gggtctggag ggccactccc cgcgcaccgt gaacgtggaa
     5641 acggcggacg acgaggtcga gcgcatccgc aagagcggcc gcctgcggct gctcggagcg
     5701 gagataggcg acgggcacga aatcgccttc gacgagccga accagctcat cctgcaccgc
     5761 cggcgctcgc tgccctacca cgccaacggc atgacgctct tcgcgtacga cgccgccggc
     5821 gccccgctgc tggagaagac gtactactcg gtcggcggcg gtttcgtcgt ggacgaggac
     5881 gcggtcggcg aggaccggat caagctcgac gacacggtgc tgaagtaccc cttccgctcc
     5941 ggtgacgaga tgctgcgcct ggcgaacgag acgggcctgt cgatctcctc cctgatgctg
     6001 gagaacgaga aggcctggcg caccgaggac gagatccgcg agggcctgct ggagatctgg
     6061 cgcgtcatgc agtcctgcgt ctcgcgcggc atgtcccgcg agggcatcct cccgggcggc
     6121 ctgcgggtca agcgccgggc cgcctccacg gcgcgccagc tgcgcaccga gggcgacccg
     6181 atgatgcacc gcagcgagtg gacgaccatc tacgcgatgg cggtgaacga ggagaacgcg
     6241 gcgggcgggc gcgtggtcac cgcgcccacc aacggcgcgg ccggagtgct gcccgccgtc
     6301 ctgcactact acgtgaactt cgtgccgggc gcggacgagg acggcgtggt ccgcttcctc
     6361 ctcgccgcgg gcgcgatcgg catgctgttc aaggagaacg cctcgatctc cggcgccgag
     6421 gtcggctgcc agggcgaggt cggctcggcc tgctcgatgg cggccggcgc cctcgccgag
     6481 gtcctgggcg gcaccccgga gcaggtcgag aacgcggccg agatcggcat ggagcacaac
     6541 ctgggcctga cctgcgaccc ggtcggcggc ctggtccaga tcccgtgcat cgagcgcaac
     6601 ggcatggcgg cggtcaaggc cgtcaccgcg gccaagatgg ccatgcgcgg cgacggcacc
     6661 cacaaggtct ccctcgacaa ggtcatcaag accatgaagg agaccggcgc cgacatgaag
     6721 gtcaagtaca aggagaccgc ccgcggcggc ctcgcggtca acgtcatcga atgctgacca
     6781 gcgacggctg acgcagcgca caggggcccg gcgcacgcgc gccgggcccc tgtcgcgtgg
     6841 ctccggttcc acgggaagtg gaactacggg gtccgaatcg gcgtcctagg ctgtgtcaca
     6901 tgtccccgtc tctcgagaat cgaggggacg tcatgatcca cccgcttcgt ccgcaccgcc
     6961 gccggatcgt ggccctggcc tccggcatcc tgctcaccgc cgggctctcg ctcgcggcgc
     7021 cggcctcggc cgccggaatc accgccaccc gcaccgagac ccagccccag accccgctcg
     7081 tcgtcaatgc ccgctggggc gggcacgcca cgtacgaccg gatcgtcatc gacctgcagg
     7141 ggttcgtccc cggggtgacc gtcaccgccg tcccacgact gatccaggac gggtccggca
     7201 agccggtacc gctggccggg aactacttcc tggagatccg cctcaacccc gccgccgcgc
     7261 acaacgacgc gggcgagagc gtctaccacg ggcccacgct gcagaagatc tacctcagca
     7321 agctcaaggg cctcgccaag accggcgact tcgaggggta cgtgaccttc ggcgccgcct
     7381 tcgacaccgt gccgtactac cgcaccttcg ccctgcactc gccggaacgg ttcgtcgtgg
     7441 acatcgcgca cgcgaaccag tgctgaccac gggcccgggg cggccgcgcc ccgggccccg
     7501 tacggtcagg cagccgggcg gatccgcatc cggcccggat ccccgtcgcc gaaccagtcc
     7561 tgggtgcagg accggcggcc cggagcggcc gcggccacca ggccgaggca tgccgccgtc
     7621 gcccgctgcc catgggcgtt ggggtgcatg gactcgtcca gcgtgccctg ggtgttgacg
     7681 tagtacagga agcggaacca ctcgtgctca cgcgggtccg ggccgccctg gcccacctgc
     7741 tccgtgccca gcgagcacac ctcgtgcccg gccagcgcgt cacgcaggtc caggtagtcg
     7801 gtgccgcgcg cgccggccac cgccttgacc atgtcgccga tcttcgggac gagcgtgtac
     7861 gccgcccagt ccgcgtcccg gtcgtcgaag gggcagccgt ccttgaacat ccggtccatc
     7921 gccacggcga cggtgggccc ggagggggtg gcggccgagg cctcgggggc ggtcagtccg
     7981 gccagcccga gcagttcgcg cggttacgcg cggctgcgcg gccgctgctg gcccggctgg
     8041 agtgggcgct ggcggaggtg ccggtgtagc cggcggtgga actgcccggg tggctaccgg
     8101 tgttcggggt tcgggaagtc gaagcggcag cccgcgtccc acagcgagcg ctggttcccg
     8161 tgtgccggga cgccgcccga gcgcttgagc agggtggcca ggtgcatcag gttccacgac
     8221 atgaaggccg tgttccggtt ggtgaagtcg ttctcggggc cgcccgagcc cgcgtcgagg
     8281 taggagggcc ccggcccggc ctcgccgatc cagccggcgt cggcctgcgg ggggatcgtg
     8341 tagccgaggt gctggaggct gtagaggatg ttcatggcgc agtgtttgac gccgtcctcg
     8401 ttgccggtga tcagcgcgcc gccgacgcgc ccgtagtagg cgtactggcc ccggtcgttc
     8461 aggaccgagg agcaggcgta gagccgctcg atgacctgtt tcatcacgga gctgttgtcg
     8521 ccgagccaga tcgggccgca caggacgagg atgtcggcgt ccatgatctg gctgtagagg
     8581 accggccact ggtcgctctc ccagccgtgc tcggtcatgt ccggccagac gccggtcgcg
     8641 atgtcgtggt cgacggcgcg gatcagcgag gtccggacgc ccgccgccgt catgaccgcg
     8701 cggctcttgt cgatcaggcc ctcggtgttg ctggtctcgg gcgagcgctt gagcgtgcag
     8761 ttcacgtaga cggcggtcag gtctgagtag tcgtagtcgg cagccacggt cccagcctct
     8821 gcgggcggcg gcgcagccgc cacccggccg cgcccgtacg gggccgggtt gtcacggcag
     8881 acgcctgggc tccgcggggc gtccctagga tggcgtcatg tcgctccccc acgccatcct
     8941 caccgccctg ctcgagaagc cctcgtccgg gctggagctg acccggcggt tcgacaggtc
     9001 gatcgggtac ttctggtccg cgacgcacca gcagatctac cgcgagctcg gccggctcga
     9061 ggagtccggg ctgatccggg ccctgccgag cgaggtgccc gtacgggggc agaagaagga
     9121 gtacgaggtc ctggccgcgg gcagcgcgga actggcgcgc tgggtcggcg agagccagga
     9181 ccccaagccg atgcgcgatc ccctgctgct gcgcatccgc gcggcgggcg tggtcggacc
     9241 gcaggggctc ggccccgagc tgcggcgcca tctggagctg caccggcggc agctggcgca
     9301 gtacggggcg atcgaggaga aggacttccc gccggagcgc gacgccgtgg aggaccggct
     9361 gcgccgcttg gtcctgcacg gcgggatcgc cctggagatg ttctggctgc actggctgga
     9421 ggaggccctg gccgaggtcg aggacatgac ggccggcgga cccggctccg gggcatgacc
     9481 gcgcccccgc cccggcaggg gggcgggggc ggcgcgggac ctgcctgcgg gacctacttg
     9541 ttgagggcgg cccagaactc gtcgaagctc agcaggccgt cgccgttggc gtccttggcg
     9601 gcgagcacgg cgtccgcgac cgcaccggtg acgtaggcgt cacccatggc cttcatggcc
     9661 gcgctgtact cgtcggccgt gatgaagccg tcaccgttca cgtcgaactt gttgaacgtc
     9721 gcccgtgcgc tctcgatgtc cgccactggg tccacccctt cttggtgctt gttgaccggc
     9781 tcagggtagc cgccccgtgc acggaccccc gctccgggtc ccgttcgggc ggcagataga
     9841 tattcaatta cccttccgca atgcggaagc gataattcca gccaataaat ccagcccgga
     9901 cttgtcacgc tccgggacca cggcataacg taacgacatt gccgccacac caggagcgca
     9961 gggctcccag ggacaagcgg caacaagggc gatcacacag gtgacgatca cagctgacgc
    10021 atcattcgaa gttctgccct tcacccgcac ttgccgccat atctgggaag acggcgacca
    10081 tgtgctcatc ggagtgagtc ctggaaacag ctacttcagt tccgagcgca tcagcagcct
    10141 cgcccagtgg gccacgaccc gcttcgcgca ggtcgacttc gtctacgcag acctccacgt
    10201 ggaccggatg ttcgccgctt tcggctacac ccgggaacat gcggagaagc gcgccacgaa
    10261 ggagatcaag gcggtccgga ggaggattct caagggcgtg gaggaatcag gacctccaca
    10321 ggccgaaatc cgcgtgaggg cactttcgga gttccaggag aaccccgttt accaactact
    10381 gcaccggcgc gtactgcatt tcctggcgac cgacgacgaa ttccgcaagg gctgcgagaa
    10441 aatggccctg cactttgtcg gctccaagtt gccggaaggt gaatcgatca cagacgcgca
    10501 gttgcaggtc tgtttcgatt acatggcggc cgagctgccg ttcttcgtgg acaccccgag
    10561 cattctcgac gtgccgtcct cggtggcggc ctaccacgtc aagatgccgc tgaccgatgt
    10621 cctcttcgcc cgcggcgggg gcctgcgcgc gacccgcaac caggcctatg ccgtcgtccg
    10681 gcccgaggcc gcagccgccg agcgcccccc ggtctccggg accgccggga accacgtgga
    10741 ccacgcaccg accgaaagga ccgtcgatga gcgtcgagca gcttgagggc cgggagggcc
    10801 gggagcggca gccgctcctc gacttcccgc tctcgcggcg cggtgacgtg ctcccggagg
    10861 agtgcggctg gctgcgcgag aaggcgccgg tcgccaaggt ccgtaccctc accggggacc
    10921 cggcctggct ggtgagcagc tacgcgctgg ccaagcaggt gctggaggac gagcggttca
    10981 gcctcaagga cacggcgaac gccggtgtgc cgcgccagta cgcgctgacg atcccgcccg
    11041 aggtcgtcaa caacatgggc aacatcaaca gcgcgggcct gcgcaacgcc gtgatgaagg
    11101 cgctcaaccc gcgccagaag gggctccagg accggctgcg cgccacggcg ggcgagctca
    11161 tcgaccagct ggtcgccgag ggcggtccgg ccgacctccg ggcggggttc gccgacccct
    11221 tctcggcggc gctgcactgc caggtgctcg gggtgccatt cgaggactgg cggcggctga
    11281 tgtcggggct ggacgtcgcg ttcatgaccg cgcgcgagcc gttcgccgac tcggccctca
    11341 actggtacaa ggacgtgggc tacttcgccg aacagctgaa cgttcagctc gccctgcctg
    11401 ccgaggagcg tacggggctc ctcggcaggt tcgccgggct gaaggaggcg gacccggagt
    11461 cggcgcacct gaccgacgac atgttcgcga cggtcgccgt ctcgctcttc ggcgcgggcg
    11521 cggtctccac ctccgcgttc ctggtcctcg ccgtcctcgc gctgctccag cggcccgagc
    11581 tcatcggcta cctgcgcaag caccccgagc gcatgggcaa ggcggtcgac gagctgctgc
    11641 gctggaacct gtccgtgggc gacggcctgc cgcgcatcgc actggccgac atccaggtcg
    11701 gcgacgtcct ggtgaaggag ggcgagctcg tcctcgtcct tctggagggg gccaacttcg
    11761 acccggaggc cttcgagaac ccggacgagc tgaacctgga gcgcgagagc cccaacgccc
    11821 acctcgcctt cggcgcggga cggcacttct gcccggcctc cgcgctgggc cgggcgcacg
    11881 ccgagatcgc cctggaggtg ctggtcgagc ggctgtccgg gctgcgcctc gcggtgccgg
    11941 cggagaacct ggtctggcgc accggcttca tcaagcggct gccggaacgg ctcccggtcg
    12001 cctggtaagg cgcaccggcg gacgtgtccc gggagctgtg cgagctcccg gggcactgcc
    12061 gtgtccgcta ccggaagatg ccggtgtggc cgagcgagta gcggccgggc tgcgggtaca
    12121 cggcgaggcc gtgcgggccg ccgccgaccg ggatccgggc gagctccttg ccggtcgcgg
    12181 tgtcgatcgc gtagacctcg gagttgtagc ggcccgagag ccacagcacc ttgccgtcgg
    12241 cggagacgcc gcccatgtcc gggctgccgc cgtcgggcag cgtccacttc ttggtgagct
    12301 tgttctgcgg gaagttgaag accgagatgg tgccttcgcc gcggttggag acgtacatct
    12361 ccttggagtc gcggctcacg tacaggccgt gacagccctt tccggtcggc agcagcttcg
    12421 ggacctcgaa ggtgtcaccg ctgagcaccc acatcccgtg cgccatcatg tccgcgacgt
    12481 agaaggtctt tccgtccggg gagaccttga cgtcctgggg catcgcgccc tcgaacggca
    12541 gtttctgctg gccgatgacc tccatcttct cggtgtcgac cttgaggagt tcgccggaga
    12601 actcgcaact cacgatgaag tagcggccgt cggcggagaa gtccgcgtgg ttgacgccat
    12661 aacaggtcac tgggacggtt ttcacccggt ccatcgtgtg cggatcgcgg aagaccagct
    12721 ctttgtccat cgaggccatg acgatcgcgt acttgccgtt cggcgtgaag tacaggttgt
    12781 acgggtcgtg cacctcgacg ggctgtccgg cctccccggt ggccggattg atcggggtga
    12841 gcgtgtggcc gcggttgttg ttgacccaca gggtcttcag gtcccaggag ggcaccacgt
    12901 gctggggctg gacgccgacc gggatggtgt cgatgacctg gtaggtcacc gggtcgatga
    12961 cggacaccgt gttggagttg gtgttcggca cgtagacgcg ggacgggaag tccttgacca
    13021 ccggggagag tttgttcggc cggtccgccg cgtacacgtc gttcggatcg agcagcgggg
    13081 gcattccggc cagacccggc ggggcggccg ggacggcctt gggcggttgg gccgggccct
    13141 tggtgccgag cgcctcggcg ggtcccttgt cggccgatcc gcagccggcc agggcggcga
    13201 ggaccagacc ggccagcagc acggcggcct tccggggaag gcaggtggtc ttcatggcgt
    13261 cagcagctcc gtggtggtca ccgcgcgcag cttgcggcgc gcgagttctt cgaggagggg
    13321 cggcatcgcg tcgaccgtgt ccgcgtagcc gaagtgcagg ctcaccaccg atccgggtcg
    13381 gatcgtcccg gtgacggtgc gggtgacggc cgcggcaccg ggcgaggtga agtcgaggga
    13441 gtccacgtcg tacgagagga cgtgcggata gccggcccgc tgggccagtt tccggacgag
    13501 cggggtggcg tactgggcct gggagggccg gaaccaggtg ccgatggagc ccgtgagccg
    13561 cttgagccgc tgggcgcagc cggtgatctc ggcgtaggcc tccgcctcgg gcatgtcgtt
    13621 gatcgcgagg tggcgctggg tgtggttgcc gagatcgtga ccgccgtcga ggatccggcg
    13681 ggccaggtcc gggtgggcgt cgagccagcc gccgatcgcc agtacggtga cccgcgcgcc
    13741 cgctctctcg gcctcggcca gtaccgcccg ggcgatggcg ggttccccgt tgccgtggaa
    13801 ggtcagggcg acccgggggc ggtcgcgcgg accgtgggcg atctcgacgg gctgtccggg
    13861 gtaccggcgc gggacggccg gggccgcctc ggccggccgg gccggtctgg cgggaccggg
    13921 gggtgcggcg gagggcgagg tggcggggcg gcccgatccg caggcggcgg tgaggccggc
    13981 cacggcgacg ccggccgtgc cgagactggc cgcgcgcagg accgcgcggc ggcctggatg
    14041 tgagagcacc tgcccattta aggggtggaa ggcccggaag gtaatgattg acccaattta
    14101 ggacgttcgc cggaatgggc caaccaggcc gcctgtccgc tatgtgatca acgattcaca
    14161 cagagcggtc gatagttatt catcgaatac gaggtgagtg gcccacctca cctaggattt
    14221 agctagaaac tctcactatt tgcacactta tgtccgagta gggacttttg gcgttcgagg
    14281 ccgcgtctgc catagtcgga accacggctt cccattgacc cgagcgaagt cgccacgccg
    14341 aggatcacac cccaatcgat cctcggcgca cccatgaagc ccccacaaac cgcccaccac
    14401 ggcgaccagg gggcttcagg cgttctggcg gtcggcgacg cgcatctcga accaggtgat
    14461 ctttccgcgc ggcagcaggt cggcgcccca gcggtcggag agtttgtcga cgaggaagag
    14521 cccccgcccg gtggtgtcca gctcgtggac cggcatcaga cagggcagtc cgcgcgaggg
    14581 gtcgcgcact tccacccgga tccagccgcg ccgccgcagc atgcgtaagc cgaaggagcg
    14641 ggccccggtg tgccggaccg cgttgccgac gagttccgag accagcagga cggcgtgctc
    14701 ggagatctgc ggcgagagtc cccagagccg tatcaccacg cactgggtga gcctgcgcgc
    14761 ggtgccggcc gattccggca tggacggcag gatcacttcc gcctcagccg ggttcccgta
    14821 caactccagt gccttgaggc cctgttcatc ctcaatcgcc gccgtgagcc gtacggccga
    14881 agcgctgctg cgctgccgcg gctgttccac accctccagg cccgccatgc acccatcatg
    14941 gagggccgac ctgcccctcc gggccgttcc acgggaaaag cccctacgga agcatcgatt
    15001 ccgcaggggc gtcctgtcat atgcaaacgg caagcggagg ctatgtatac ccactttgac
    15061 caggggtgac gcaccgctca gaagtgatca ccgtgagtgg atcaccgatt gcgcttaagg
    15121 ctcccttaag gcctggctaa tccacccaca gggaggaccg gccgcatccg ctcagcggac
    15181 cgggttcata cgaacttcgc cttgcccggg ccctcttcga cgaaactgcg catgccgcgc
    15241 tcgcggtcct cggtggcgaa caggcccgcg aaccagttgc gttcgatggt gagcccggtg
    15301 tcgatgtcgg cctccaggcc cgcgtccacg cactccttgg cggcgcgcag cgcgatcgcc
    15361 ggaccctggg ccagcttggc ggcccaggcg tgcgcctgct cgtacacctc ggccgcgggg
    15421 accacccggt cgacgaggcc cagcgcgagc gcctcgtcgg ccttgaccat gcgcccggtg
    15481 aagatgaggt ccttggcctt ggacggaccg atcagccggg acagccgctg ggtgccgccg
    15541 gcgcccggga tcaggccgag caggatctcg ggctggccga gcttcgcgtt gtcggcggca
    15601 atccggtagt cggcgcagag cgcgagctcg caacccccgc ccagcgcata gccggtgacg
    15661 gccgcgacga cgggcttggg gatgcgggcc acggcggtga aggagtcctg cagcgcgcgg
    15721 gaccgggcga tcatcgccgc gtggtccatc gcctgcatct ccttgatgtc cgcgcccgcc
    15781 gcgaacacct tctcgccacc gtagatgatc accgcgcgga cgtcgtcccg gtcggtcgcc
    15841 tccaccgcga gctcgcgcag ccggtcctgg gtggcgatgt ccagggcgtt catgggcggc
    15901 cggtccaggc ggatggtgcc gacgccttcg gagacttcga gagagatggt catacgggga
    15961 aggttagcgc cggttaacgg acggtggccc ggtgctgtgt gtcacagcac cgggccacct
    16021 ggactacgtc atgcggggct tacttgatcc actccgccca gtccatgttc cagccgttga
    16081 ggccgttgtc cggggagatc tgcttgtcct tggagttctt cacgatgacc acgtcgccga
    16141 tcagggactc gttgaagaac caggcggcgg gctggttgcc gtcgccggcg ccgcggacgt
    16201 ccttcaggcc gacgcagccg tggctgacgt tctccgagcc gaacgtgccc gaagaggccc
    16261 agtagttgcc gtgcacgaag gtgcccgagt tcgacaggcg catcgcgtgc ggcacgtcgg
    16321 agatgtcgta ctccccgccg aagcccaccg tcgccccgtt catccgcgtg accttgtact
    16381 tctcgctgat gaccatctgc ccgttgtacg tggtcgtcga cggggcgccc gcggtgatcg
    16441 ggatgttctt gagcacctgg ccgtcgcgga cgacctccat ggtgtgctcg ctcgcgtcga
    16501 ccgtggagac ctgggagcgg ccgacggtga aggtgaccgt gcgggtctgc ttgccgtaga
    16561 cgcccgggcg gccttcgact ccgtcgaggg cgagcttcac ggtgaccttc gtacccgcgg
    16621 cccagtactt ctcggggcgg aagtcgaggc ggtcgttgcc gaaccagtgg ccctcgacgg
    16681 gcaccgccgg ctcggccgtc acggtgatgg ccttctcgac ggcctcgggg ttggtgatgc
    16741 cgcgggtgaa gttgatcgac acgggcatgc ccacgccgac ggtggagccg tcctcgggcg
    16801 tgtagtggcc gatgaaggtg ttcgtcgggg tcagggtggt gaaggtggtg tccttggcgg
    16861 actcccggcc ggcctcgtcc ttggcgaccg cgtgcacctt gtactcggtg gcggaggcca
    16921 ggtggcggga cggctcccag ctcgcgccgt cgtcggccag cttgccctcg accgcgttgc
    16981 ccttggtgtc ggcgacggtc accgtggtga gcttgccgcc ggtgctggtt atcttcagga
    17041 tgccgctggt ggcgacctcc ttggcgccgt cgtccggctt gacgctgacc acggccttgg
    17101 atgcctcggt gccgttcttg gcaccgcccc cggcattgtc gccaccgctg ccgctgccgt
    17161 tgtttccgcc gccgccaccg ctgcacgcgg tggtcagcag cagggcggcc cccagcagaa
    17221 gggccggcag gccggtgcgg acgcggccgc gtatcggctg caggttcact cttgttctcc
    17281 ccatgtcccc cgcgcgcggg cagtcgcgcg cttatcgaca ggaaatcaca tggggagaac
    17341 acgaaaagcc acggtcatgt caccgttccg tcccaagtgg cgggccggtc aggcgatggc
    17401 ggagccggcg acccagtcgg cccaggacat gttccagccg cccaggccgt tgttcggggc
    17461 gaccgtcttg tcctgcgagt tgaggatctc caccacgtcc ccgaccaggc tccggtcgaa
    17521 gaaccagccg gccggggtgt ccgagccgcc gcccttgtcg tcgcgcaggc ccacgcaccc
    17581 gtggctcacg ttggcggagc cgaaggtgtc gggactggcc cagtagttgc cgtgcaggaa
    17641 ggtcccggag gaggtgagcc gcatggcgtg cgggacgtcg ggaatgtcgt actccccgcc
    17701 gaagccgacg gtctggccgt tcatgcgggt gacgtcgaag agctccatca ccaccatctt
    17761 cccgttgtag gtggtggtct tgggcgctcc cgcggtgatg ggcagggtct gcagcagccg
    17821 gccgtcccgg cggatctcca tggtgtgcgc ggccgcgtcc acggtggaga tctgcgagcg
    17881 gccgacggtg aaggtgatcg tcttggcctg gatgccgtag gagccgggcg cgccctcgat
    17941 gtcgcgcagg ttcatcttca ccgtcacctc tgtaccggac ttccagtact ccttgggccg
    18001 gaagtcgagc cgctccttgc cgaaccagtg gccgacgatc tccaccggcg ggttcgaggt
    18061 gacggtgatg gcccgctcca cctcggcgcg tcgcgcgatg gcccggttga agttgaagga
    18121 gacgatcatt ccggtgccga cggtggagcg gttctccggc ttgaagtagc cgatgaaccg
    18181 ttcctcggga acgtaggtgg tgaaggtggt gtggcgggcc tggcggcggt cgtgcccgtc
    18241 gagggcgacg gcgtccacgg tgtacttggc cgcgagcgag agacgggcgg cctccggatc
    18301 ggggctccag ctgagcccgt cctcggcgat cgcgccggga accttctcct cctgcgcgtc
    18361 ctccaccttg gtcaccacga cccgctccag ccggccctcg gggaccgtga cgctgaggcg
    18421 cccgccggcg ggcaccccct tggcattgtc gtcgggggtg atgcggatgg cctcgtccgg
    18481 cgagcggggt ttgccgggca actcgatctc gaccggggaa cggccgtcct gggtgcatcc
    18541 ggccaggccg ccgagcaggc ccgcccatgc cgccacggcg gccaagcccg cccctgcccg
    18601 cctcgtcaga agtgtcacga tccctccaac gaccgggccc ctccggggga aacgtgagcg
    18661 gcgcgcacgt tccgggcgga acagtccggg cagaacagtg tgaaggacca gacgggggcg
    18721 ggcccaggcc gggacgccgg ggccgcaccc cccacccccg caggtaccca ggagccgtgg
    18781 aggcgggcag tgtcgagcgc agccgagcag gaagaggcgg tggaagccgt cggcaatgtg
    18841 gtggacgccg cgaacgcggt ggacaccgag agcgcggtcc ggggcggccg taccgcgccc
    18901 gtgccgggcg gccaggtcag gggccaggtg ttacgggcgt acgcgcgccc gggaccaccg
    18961 gtgtggcccg ggtcctcgca tcccctgggg gcccggttcc accacggtcc ggacgggacg
    19021 gcgggcacca acttcgcgct gtgggcgcag ggcgcggagg cggtggaggt gtgcctgttc
    19081 gaggagggcg gggccgagac ccgctgcgcc ctgacggagc tcacgcacga gatctggcac
    19141 ggtttcgtgc ccggcgtacg ccccgggcag cggtacggat ttagggtgca cgggcgctgg
    19201 gacccctgga ccggtgcccg gtacaacccg tcgaagctgc tcctggaccc gtacgcccgg
    19261 gccgtggacg gcgagttcgt cctgccgccc gaggtgtacg ggcacgtgcg ggactggccg
    19321 cagcagtaca tcgccgacac cgtgcgcgac gaccgcgact cggcgccgtt cgtccccaag
    19381 ggggtcgtgg tccacgatga cgacgactgg gcggacgacg tccggccgaa gaccccctgg
    19441 gccgattcgg tgatctacga gctgcacgtg cgcggcttca cgatgcggca tccgggggtc
    19501 cccgaggaac tgcgcggcac gtacgcgggc ctcgcccatc cggcggcggt cgagcacctg
    19561 gtgaagctgg gcgtgacggc ggtcgagctg ctgccggtgc accagttcgc gcacgaggac
    19621 cacctgctgc gccgggggct gcgcaactac tggggctaca actcggtcgg ctacttcgcc
    19681 ccgcacgccg gctactcgtc gagcggtacg acgggccagc aggtcgggga gttcaagcgg
    19741 atggtgcggg ccctgcacgc ggcggggatc gaggtcatcc tcgacgtggt ctacaaccac
    19801 acggcggagg cgggcgagct cggaccgacg ctgtccctgc gcgggatcga caaccggggc
    19861 tactaccggc tccagtccga ccagcgccgg tacgccgact acacgggctg cgggaacacc
    19921 ctgcacgcgg ggcgcccgca cgtactgcgc ctgatcacgg actcgctgcg gtactgggtg
    19981 acggagatgg gggtggacgg cttccgcttc gacctggcgg cggcgctggc ccgctcgatg
    20041 cacgacgtgg acatgctgtc gccgttcctg gcggtgatcg cccaggaccc ggtgctgcgg
    20101 cgggtcaagc tgatcgcgga gccctgggac gtgggctcgg gcggctacca ggtgggcgcc
    20161 ttcccgccgc tgtggacgga gtggaacgac cgctaccggg atgccgtgcg ggacttctgg
    20221 cggggcgcgc tgcccgacgt acgggacctc gggtaccggc tgtcgggatc gagcgacctc
    20281 tacgcgtggg gcgggcggcg gccgtacgcc tcggtgaact tcgtgacggc gcacgacggg
    20341 ttcaccctga gggacctggt gtcctacgag cgcaagcaca acgaggcgaa cggggaggcg
    20401 ggccgggacg ggacgaacga caaccggtcg tggaactgcg gggcggaggg cgatccgccc
    20461 gagggcacgg atgcccggat cgccgcgctg cgccgccggc agctgcgcaa cctcctcacc
    20521 accctgctgc tgtcgacggg ggtgccgatg ctcgtcgcgg gggacgagtt cgggcgcacc
    20581 cagggcggca acaacaacgc gtactgccag gacaacgaga cggggtgggt ggactggtcg
    20641 ctgctggagg atccggcgtg gcgggagctg ttcgcgctga ccgcgcggct gatctcgctg
    20701 cgccaggccc atccggtgct gcggcggcgg gcgttcttct ccgggcggcc gcagggggtg
    20761 gacgggctgc gggacctggc ctggtt
//
