LOCUS       NZ_CP102509            20906 bp    DNA     linear   CON 06-JAN-2024
DEFINITION  Streptomyces sp. NBC_00162 chromosome, complete genome.
ACCESSION   NZ_CP102509
VERSION     NZ_CP102509.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NBC_00162
  ORGANISM  Streptomyces sp. NBC_00162
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8635149)
  AUTHORS   Nielsen,J.B., Gren,T., Mohite,O.S., Joergensen,T.S., Klitgaard,A.,
            Mourched,A.-S., Blin,K., Larsen,T.O., Weber,T., Gotfredsen,C.H. and
            Charusanti,P.
  TITLE     Identification of the biosynthetic gene cluster for pyracrimycin A
            and elucidation of a key reaction during its biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8635149)
  AUTHORS   Joergensen,T.S., Gren,T., Blin,K. and Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2022) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-AUG-2022
            Assembly Method :: Flye v. 2.9-b1768; Polypolish v. 0.5.0; POLCA
            polisher from MaSuRCA v. 4.0.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/05/2024 18:03:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,275
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,805
            CDSs (with protein)               :: 7,805
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 371
            CDSs (without protein)            :: 370
            Pseudo Genes (ambiguous residues) :: 0 of 371
            Pseudo Genes (frameshifted)       :: 186 of 371
            Pseudo Genes (incomplete)         :: 231 of 371
            Pseudo Genes (internal stop)      :: 27 of 371
            Pseudo Genes (multiple problems)  :: 68 of 371
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:41:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1264154
            Orig. end                         :: 1285060
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102509.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Tilmann Weber, Dr.
            Professor, Novo Nordisk Foundation Center for Biosustainability,
            Kemitorvet, 220, 327D 2800 Kgs. Lyngby, Denmark.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20906
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20906
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20906
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10906](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10906)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    381..394
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            complement(808..2112)
                     /locus_tag="JIW86_RS06605"
                     /old_locus_tag="JIW86_06605"
     CDS             complement(808..2112)
                     /NRPS_PKS="Domain: Abhydrolase_1 (48-215). E-value:
                     4.7e-19. Score: 60.9. Matches aSDomain:
                     nrpspksdomains_JIW86_RS06605_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983441.1"
                     /locus_tag="JIW86_RS06605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06605"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_257559238.1"
                     /sec_met_domain="PF00561 (E-value: 7.4e-17, bitscore: 60.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHSYRQPGTVLTDHRFTVPLDHARPDGEHIELYAREVVASGKDP
                     QTLPWLLYLEGGPGFGARRFIGRQAWLERALADYRVLLLDQRGTGRSTPVNRQTLPLRG
                     APAQQAEYLAHFRSDSIVRDAEAIRPALTGGAPWTVLGQSFGGFCATHYLSTAPEGLSA
                     ALITGGLPSLTATADEVYEAAYPRIERKNLAHYARYPMDVERARRIAAHLAERPAELPG
                     GYRLTVEAFRSLGLLLGSGDGSHQLHYLLEDAFVRTPAGPALSDAFLEGAHALLSFAGH
                     PLYALVHEAIYAQDPAVPTAWAADRVGAGHPRFDAAKTLAGDEPLLFTGETIHPWHFTV
                     DPSLAPLRETAELLAARTGWEPLYDPARLAANEVPVAAAVYHDDMYVDTAHSLETARAV
                     RGLRTWVTDEFEHDGVRAGGPRVLDRLLALVRGEA"
     aSDomain        complement(1468..1968)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS06605_Abhydrolase_1.1"
                     /evalue="4.70E-19"
                     /label="JIW86_RS06605_Abhydrolase_1.1"
                     /locus_tag="JIW86_RS06605"
                     /protein_end="215"
                     /protein_start="48"
                     /score="60.9"
                     /tool="antismash"
                     /translation="PWLLYLEGGPGFGARRFIGRQAWLERALADYRVLLLDQRGTGRST
                     PVNRQTLPLRGAPAQQAEYLAHFRSDSIVRDAEAIRPALTGGAPWTVLGQSFGGFCATH
                     YLSTAPEGLSAALITGGLPSLTATADEVYEAAYPRIERKNLAHYARYPMDVERARRIAA
                     HLAE"
     gene            complement(2233..3321)
                     /locus_tag="JIW86_RS06610"
                     /old_locus_tag="JIW86_06610"
     CDS             complement(2233..3321)
                     /EC_number="1.1.1.306"
                     /GO_function="GO:0050607 - mycothiol-dependent formaldehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0010127 - mycothiol-dependent
                     detoxification [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (25-256). E-value: 1.5e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_JIW86_RS06610_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267920.1"
                     /locus_tag="JIW86_RS06610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06610"
                     /product="S-(hydroxymethyl)mycothiol dehydrogenase"
                     /protein_id="WP_257559239.1"
                     /sec_met_domain="ADH_N (E-value: 5.2e-28, bitscore: 95.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.6e-29, bitscore:
                     99.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHRVRGVIARSKGAPVETTTILVPDPGPGEALVRVQACGVCHTD
                     LHYREGGINDEFPFLLGHEAAGIVESVGPDVTSVAPGDFVVLNWRAVCGTCRACKRGRP
                     WYCFATHNATQPMTLEDGTPLSPALGIGAFAEKTLVAAGQCTKVDPAAAPAAAGLLGCG
                     VMAGLGAALNTGNVGRGDSVAVIGCGGVGNAAVAGARLAGASKIIAVDLDDRKLEWARG
                     LGATHTVNGRKEDVVQAIQGLTDGNGADVVIEAVGRPETYRQAFYARDLAGTVVLVGVP
                     TPEMKLELPLLDVFGRGGALKSSWYGDCLPERDFPMLVDLYLQGRLDLDAFVSETIPLD
                     GVEAAFARMERGEVLRSVVEFP"
     CDS_motif       complement(2485..2517)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIW86_RS06610_0002"
                     /evalue="1.00E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="JIW86_RS06610"
                     /protein_end="279"
                     /protein_start="268"
                     /score="3.0"
                     /tool="antismash"
                     /translation="RDLAGTVVLVG"
     aSDomain        complement(2554..3246)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JIW86_RS06610_PKS_ER.1"
                     /evalue="1.50E-10"
                     /label="JIW86_RS06610_PKS_ER.1"
                     /locus_tag="JIW86_RS06610"
                     /protein_end="256"
                     /protein_start="25"
                     /score="32.6"
                     /tool="antismash"
                     /translation="DPGPGEALVRVQACGVCHTDLHYREGGINDEFPFLLGHEAAGIVE
                     SVGPDVTSVAPGDFVVLNWRAVCGTCRACKRGRPWYCFATHNATQPMTLEDGTPLSPAL
                     GIGAFAEKTLVAAGQCTKVDPAAAPAAAGLLGCGVMAGLGAALNTGNVGRGDSVAVIGC
                     GGVGNAAVAGARLAGASKIIAVDLDDRKLEWARGLGATHTVNGRKEDVVQAIQGLTDGN
                     GADVVIEAV"
     CDS_motif       complement(3103..3141)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JIW86_RS06610_0001"
                     /evalue="3.10E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="JIW86_RS06610"
                     /protein_end="73"
                     /protein_start="60"
                     /score="10.6"
                     /tool="antismash"
                     /translation="LGHEAAGIVESVG"
     misc_feature    complement(3516..3529)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.19"
                     /tool="antismash"
     gene            complement(<3646..4326)
                     /locus_tag="JIW86_RS06615"
                     /old_locus_tag="JIW86_06615"
                     /pseudo=""
     CDS             complement(<3646..4326)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="JIW86_RS06615"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06615"
                     /product="LysR substrate-binding domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLDVRRLRLLRELARRGTIAAVAEALAFSPSAVSQQLAVLEREAG
                     LPLLERTGRRVRLTPAGQHLVGHAEAVLERLEQAESDLAEARGGLAGALRIGAFPTATR
                     AIVPAALTALARRHPGLEPMVRETDPAAVAHALRSGDLDVALIHAYDFVPAAQEPGLAT
                     EPLYGEAMYLAAPAAGFPEPPPGDDQNAVLRAHAEDPWITATPGTLCHAMTVRACQAAG
                     FSPRV"
     misc_feature    complement(4342..4355)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.66"
                     /tool="antismash"
     gene            4398..5335
                     /locus_tag="JIW86_RS06620"
                     /old_locus_tag="JIW86_06620"
                     /pseudo=""
     CDS             4398..5335
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012904.4"
                     /locus_tag="JIW86_RS06620"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06620"
                     /product="dihydrodipicolinate synthase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAQDTTQNPARALSPAAASLHGIHVPLVTPFDRAGEVAAEALEGL
                     AHEVLDAGATGIVALGTTAESAALDEAERDLVTDVCARVCRERGATLTVGAGASGTRAA
                     EASLARLTRWPQARAALVTVPSFVRPAAAGCWHTSRTWPR"
     misc_feature    complement(5420..5436)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 18.87"
                     /tool="antismash"
     misc_feature    complement(5449..5464)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.38"
                     /tool="antismash"
     gene            5711..6445
                     /locus_tag="JIW86_RS06625"
                     /old_locus_tag="JIW86_06625"
     CDS             5711..6445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377823.1"
                     /locus_tag="JIW86_RS06625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06625"
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="WP_257552920.1"
                     /transl_table=11
                     /translation="MPAKGKHRRPKHHPITRKLALVGTGGAALTLPLISATTAGAVATT
                     TAPAAHTAAPAAPTATPTTYSVVAGDTLSEIAADHSVSGGWKKLYAANRSVIGDNPAII
                     RPGIKLNLGTQDETARASRSAARPALAPAAKPAYANNLDGWIRESLDVMAKHGIPGTYN
                     GIHRNVMRESSGNPLAINNWDINAQNGIPSKGLLQVIDPTFQAYHVPGTSQDSYDPVAN
                     ITAACNYAAARYGSIDNVNGAY"
     gene            complement(6452..7057)
                     /locus_tag="JIW86_RS06630"
                     /old_locus_tag="JIW86_06630"
     CDS             complement(6452..7057)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744173.1"
                     /locus_tag="JIW86_RS06630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06630"
                     /product="response regulator transcription factor"
                     /protein_id="WP_257552921.1"
                     /transl_table=11
                     /translation="MIRVLLAEDQGMMRGALALLLGLEEDIEVVAQVAAGDEIVPAALE
                     ARPDVALLDIELPGRSGLDAAAELRTRCPGCRVLILTTFGRPGYLRRAMEAGAAGFLVK
                     DGPVEELAAAIRRVLAGETVIDPSLAAAALGAGPNPLTRREVDVLNAAVDGATVADIAA
                     KLYLSESTVRNYLSSAIGKTGTRNRMEAVRAARRQGWL"
     gene            complement(7054..8220)
                     /locus_tag="JIW86_RS06635"
                     /old_locus_tag="JIW86_06635"
     CDS             complement(7054..8220)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530521.1"
                     /locus_tag="JIW86_RS06635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06635"
                     /product="sensor histidine kinase"
                     /protein_id="WP_257552922.1"
                     /transl_table=11
                     /translation="MQDQGQGQGQGQGCGQGRGHGPVGPPSAFTLLPWLLLGMGAMSNV
                     VHGETPNPWIGGLGLLVFNSLYITLVFRAFHKPAREARSTRWCLIALGAVTCALAIAYG
                     DNWLLFFPLLGLATGAVVRGRRLGPVMFGVTALAGVIAGLQQGWDALGIVYGTFLSGMV
                     TAAILALSETVKELRDTRQELARAAVDQERLRFSRDLHDLLGHTLSVIVVKSEAARRIA
                     PRDMDAALEQVRDIESVGRQALTEIREAVTGYREASLAAELDRARGALTAAGIEPVVRQ
                     AGPPLPPQAAALLGWVVREAVTNAVRHSGADTCEIELRSSAEKVRLVITDDGGGVGSTA
                     PGSGLTGLTERLAVAGGTLRSGPVPGRGFRVTAELPLEPAGQGIEERA"
     gene            complement(8242..8958)
                     /locus_tag="JIW86_RS06640"
                     /old_locus_tag="JIW86_06640"
     CDS             complement(8242..8958)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033208.1"
                     /locus_tag="JIW86_RS06640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06640"
                     /product="ABC transporter permease"
                     /protein_id="WP_257559240.1"
                     /transl_table=11
                     /translation="MTAYVRLEVRRTLRDTAFVVFGIGMPVLMYLMFTNLGSSGTEWRT
                     ASMVAMAAYGALGAALSTGTGVAEDKGVGWLRQLRVTPMTPRQVVAGRALTGSVIVLPA
                     IAAVLAAGAVVNGVRMEAWQWGALILVLWLGAFPFTLLGLGNGYRLTAQTTGLVNVGCS
                     LALSVAGGLWFPVELFPQWLRSLSGLTPTRRFAEIGQSVATGAAPGPVAVAVVAVWALV
                     FGSYAVLSYRRSARTA"
     gene            complement(8958..9905)
                     /locus_tag="JIW86_RS06645"
                     /old_locus_tag="JIW86_06645"
     CDS             complement(8958..9905)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103433.1"
                     /locus_tag="JIW86_RS06645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06645"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257552923.1"
                     /transl_table=11
                     /translation="MTQTTKTSPGERPAIRFRHAAKSFGPVHAVAGIDLDIRRGETVAL
                     LGRNGAGKSTAISLLLGLNEPDAGSVRLFGETPGQAVRAGRVGAMLQEGRAVPRITVRE
                     LIAFVTRTYPAPMPVAEALELAGLTALAGRRIDRLSGGQAQRVRFAVALAGNPELIVLD
                     EPTAALDVEARRAFWASMRGYARRGNTVLFSTHYLEEADAHADRIVVVDRGRIVADGTG
                     EQLRRAAGGSLVSFDLAGHSSAPLGALPGVVSVEVRGDRARLRTQDPDATVVALAGLGA
                     VRGIEVTAPSLDEAFLALTEAGVTGPTIAAGSAR"
     gene            complement(10001..10906)
                     /locus_tag="JIW86_RS06650"
                     /old_locus_tag="JIW86_06650"
     CDS             complement(10001..10906)
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.4"
                     /locus_tag="JIW86_RS06650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06650"
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_322975606.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.5e-08,
                     bitscore: 33.0, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 7.7e-12, bitscore:
                     43.9, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHHTHGRRDIRHPAAGGLHPRRPPGTPPRTRPVPRAAPARRAAP
                     GALARRRPRLHEPGRRRGRDRHSGATGRQPGRVDRAGRSRPEDRGQPRPLLRAYAHAVD
                     SRALPAHWVSRFLEGAATAEAGFDGFADEAEFQAYLDAYAWPGVLVFTGLQYQGGPDPE
                     QAAAWRRFVDAAQRVDFLADLAGDLADGRLCIPRARLDEHSVTRADLEQARDTPAVRAL
                     LAAETGRARAALEATDGILDLADPGLRPVTATMKELMAQQLTAVERAGITALRRDTGYG
                     LVAPLRTLLRARAGVRSRTP"
     gene            complement(10985..12619)
                     /locus_tag="JIW86_RS06655"
                     /old_locus_tag="JIW86_06655"
     CDS             complement(10985..12619)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068168.1"
                     /locus_tag="JIW86_RS06655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06655"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_257552925.1"
                     /sec_met_domain="Pkinase (E-value: 2.3e-48, bitscore:
                     163.7, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTSEAGRQPIDGRFELVAPLGSGGMGTVWRARDIALHREVALKE
                     VRPPDPATAAAQPGLAAQLRERAVREARALARLAHPHVVTIHHIVEPAVGTDGHPWIVM
                     ELVKGGSLHDRLASGPLPTADVLRLGLDLLSALRAAHAEGVLHRDVKPANVLLRPDGSA
                     VLTDFGIAALHGSTGLTSTGVLIGSPEYIAPERVRGEEGLAASDLWSLGMLLYVAAEGV
                     HPLRRATSLATVVAVLDEPIPAPVRSGPLAPVLERLLVRDPAARPDAEQLEQLLRDAST
                     ALATAPAGQAAPPVVGQYGPPTPPPFGPVPHPYAVTAPLPADATPRRRPVLLGAALAAV
                     LVAGTVGIVKWLPDGSASGGDAKGGISSGPTGSAGPATSPAPSTPGPKASTSKGEAPQG
                     SLLTPASIRTALAALKQQTGTTSFVNLRIYDDYVIASVPTAPGAKTVDSWQYRDGGVTR
                     TGPAGTVKDRAPLIDMATVEWDTLPALLEQAKKDLGVANPTTRYVIVEPWMLDQSPSMR
                     PYLSDEYGQGGYVLAGTDGKVRKVYRS"
     gene            complement(12647..14285)
                     /locus_tag="JIW86_RS06660"
                     /old_locus_tag="JIW86_06660"
                     /pseudo=""
     CDS             complement(12647..14285)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040929.1"
                     /locus_tag="JIW86_RS06660"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06660"
                     /product="peptide-N4-asparagine amidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRRHRIMGLLGALTLAAATLAGTAGPANAAAPVPAPGGGTPPAEF
                     GTDWHDPLTAGPPVARPGTRSCEVTLAEAQFRDFTPYRGNYAPPQGCGADHWAAVVLRL
                     DGKVKGRQYDRLGHLSLGGVEILRTSTPSPRPTASPGPSRRTSRATATPSPARSPSRC"
     gene            complement(14408..14674)
                     /locus_tag="JIW86_RS06665"
                     /old_locus_tag="JIW86_06665"
     CDS             complement(14408..14674)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380038.1"
                     /locus_tag="JIW86_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06665"
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_215149134.1"
                     /transl_table=11
                     /translation="MGIIGWIILGLLAGGIAKVLLPGRDPGGLIGTTLIGVAGAFIGGW
                     LSAKFLDRPIQTQFFDVATWGSAIAGSLVLLIGYRILFGNSRD"
     misc_feature    14665..14679
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.44"
                     /tool="antismash"
     misc_feature    14670..14683
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.16"
                     /tool="antismash"
     gene            complement(14752..15644)
                     /locus_tag="JIW86_RS06670"
                     /old_locus_tag="JIW86_06670"
                     /pseudo=""
     CDS             complement(14752..15644)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005484716.1"
                     /locus_tag="JIW86_RS06670"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06670"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNATALAVGLCLASAVAYAAAAVAQERLARAGAARSAKALLGNGA
                     WWWSAGLNAAAALLHAAALRYGPLTLVQPLGALTLVAAVPLGARGSGRRVAATEWRGTL
                     ATVAGLGLLLLPASGPAPDDTLTLAEALAVSGATAAVILLLTAAKDPRSGLRHATASGL
                     ASAAASALTQTVAVAGAAADPCSASGSSPWPCSSWCSPSAGCCCRSGPTGAGSVPRSPW
                     STWPTRWPRPRSAWSCSANASRAARRECCWPWPEPWPRRAGSSC"
     gene            complement(15641..16434)
                     /locus_tag="JIW86_RS06675"
                     /old_locus_tag="JIW86_06675"
                     /pseudo=""
     CDS             complement(15641..16434)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037724.1"
                     /locus_tag="JIW86_RS06675"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06675"
                     /product="phosphatase PAP2 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSHITPAGAAAARRAARRRLIRELLLVAGLFTVYKAGRMLSTGR
                     TEEAFRNAARIWDAERALHLPGEGAVQRLLLHGDTLVHTANTYYAAVHFPATALFLIWL
                     YLRRPDHYLWARRVLAVLTGAALALHLAFPSRPRGCSRPRT"
     misc_feature    complement(16524..16535)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            16586..17212
                     /locus_tag="JIW86_RS06680"
                     /old_locus_tag="JIW86_06680"
     CDS             16586..17212
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994311.1"
                     /locus_tag="JIW86_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06680"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_257552926.1"
                     /transl_table=11
                     /translation="MTSTPTTARRSKITPEREQEFFDAVLEQLREHGYEALTMEGVAAR
                     ASCGKSTLYRQWKTKPQLVAAALRANRQGTLVAVDTGTLAGDLREAARIAACTSGRDTR
                     LTQALGHAVLSDEELQAALREALVEPELAAFAVMVERAVARGEITADHPAVEFLPAQLM
                     GVLRIRPVLEGRYADADYLVRFVDAVMLPSLGLTPPGTPGIPGTP"
     gene            complement(17367..17897)
                     /locus_tag="JIW86_RS06685"
                     /old_locus_tag="JIW86_06685"
     CDS             complement(17367..17897)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004982583.1"
                     /locus_tag="JIW86_RS06685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06685"
                     /product="TerD family protein"
                     /protein_id="WP_257552927.1"
                     /transl_table=11
                     /translation="MTGVRKGLAKVEVALRWDPSPAERPAHDLDIVAAVYGAADLHGVP
                     VHLVHFGSRSPDGTITLNRDSHTGQGFGFDEVMTLELDRMASELHRVVVGVLIQDTGGR
                     RATFADIAGTGVRIREGHTDLAQGDFDAIPSATAATVAVFTRDDSGSWSLDARLQGFDA
                     DPEEFTRTMGAVR"
     misc_feature    17965..17978
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            complement(17994..19172)
                     /locus_tag="JIW86_RS06690"
                     /old_locus_tag="JIW86_06690"
     CDS             complement(17994..19172)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100503.1"
                     /locus_tag="JIW86_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06690"
                     /product="VWA-like domain-containing protein"
                     /protein_id="WP_257552928.1"
                     /transl_table=11
                     /translation="MSLDRAKLLAARYKAAEARPYLASALYALTVVPSDGVRTMGVDRH
                     WRCYVSPAFVEATPVVELAGVWIHEVAHLLRDHHGRAERLPAADQRDPVRVNIAQDCEI
                     NDDLLADGLALPEGRMEPRLFGLATGGLFEAYLPAIPPTPHGVDCGSGAHGTPMPWELG
                     EDGGPARVGPVEAEALRRQTAQAVRAQQRTRGTIPAGWARWAQELLEPTVDWRRALSGA
                     VREAAAWAAGAVDYTYRRPSRRTPALGGRVVLPSLRRPLPRVAIVIDTSGSMGPDDLAA
                     ALAEVTGVLREVGVGGNRVAVLACDADVHAVTRVRSAGEVTLAGGGGTDMRVGIGAALA
                     LPDRPNVVVVLTDGYTPWPDETPSCRLIAALVGANPPAPPAWVETVRVDLAT"
     gene            complement(19186..20382)
                     /locus_tag="JIW86_RS06695"
                     /old_locus_tag="JIW86_06695"
     CDS             complement(19186..20382)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523823.1"
                     /locus_tag="JIW86_RS06695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JIW86_06695"
                     /product="AAA family ATPase"
                     /protein_id="WP_257552929.1"
                     /transl_table=11
                     /translation="MSAQPQPARALAAADALGARLSAIRTEPATNPQLEALALAVTANQ
                     PVLLWGEPGIGKSAGMQQLATALGVELETVIASVHEPSDFAGLPIVGEDPATTGVPMAP
                     PDWAVRLARTGHGLLFFDELSSAPPAVQAALLRVVLERRVGSHELPAAVRIVAAANPPA
                     SAADGWHLSPPLANRFVHLDWTHNPRTVARGMAGTWPEVAIPAVDPAKASGSVARARGA
                     VSGFLTARPGLVHHMPAEAAARGRGWPSPRTWEMALRLLATGYAASTGREALAMALTGA
                     VGEAAGIELLSYLEHLDLPDPDRVLADPDAFALPERGDRQLAFLIAVVAAVQSELTRPR
                     WEAGWAVLAKAVDAGVPDVAARAAADLAAMRDLDWPVPAGIDAFVELLQLSGSLPGGG"
ORIGIN
        1 agacctcgaa cggcaccgcc gggcggccgc cgaaccgggc cgccgcctgc tgggcgttgc
       61 cggtcaggaa ggtgcggacg tactccgccg ggtcctggtc cgtgagcacc tcgatgtacg
      121 acttgtgctc gagcagggac gtgatcgacc gcaacaggcc cggaccggcg tcggccgcgt
      181 gcgtgggcgt gctggagccg gacacggcga cccagcgcac tccgttccac ggctccaggc
      241 cctgctcggt gaggagttcg gggaagatcc accggtttcc ggcgtcaccg gccgcgtcca
      301 gggtggcccg gccgacggcc ttgtggtcgg gggtgttcca gtagccgcca ccttgcgcac
      361 cgccccacgt gtcacggtgg ttgagcgtga tcaccagctc cgggcggtgc cggcggatgg
      421 ccgccgcgat gtcccggcgc aggtcgaggc cgtactcgac cacgccgtcg cggtagtcga
      481 ggaactccac ctcggacacg ccgacgacgg ccgcgctcgc ccgctgctcc gcctcgcgca
      541 gcggtgcgca gtcggcgggg gcgatggtgt cgatacccgc ttcacctcgg gtggcgagca
      601 ggtagacgac ctcgcggccc ccgtcggtcc agtccgcgat ggccgccgcg cagccgtact
      661 ccaggtcgtc cgggtgggcg acgacggcga gggcgcgctg ccagtcggtg ggcatgggct
      721 gcaagggggc gggctgatca ggctgttcgg tcatgggtcg caccataaac gaacggaccg
      781 acaacgacgg gtcccggcac ggcccggtca ggcctcgccg cgcaccaggg ccaacagccg
      841 gtccaggacg cgcgggccgc ccgcgcggac gccgtcgtgc tcgaactcgt ccgtcaccca
      901 ggtccgcagg ccccgtacgg cgcgggcggt ctccagggag tgagcggtgt ccacgtacat
      961 gtcgtcgtgg tagacggcgg cggccaccgg cacctcgttg gccgcgagcc gggccgggtc
     1021 gtagaggggt tcccagccgg tacgggcggc cagcagttcg gcggtctcgc gcagcggggc
     1081 gagggagggg tccacggtga agtgccaggg gtggatggtc tcgccggtga agaggagggg
     1141 ctcgtcgccc gcgagggtct tggcggcgtc gaagcggggg tggccggctc ccacccggtc
     1201 ggcggcccag gcggtgggca cggccgggtc ctgggcgtag atcgcctcgt ggaccagcgc
     1261 gtagaggggg tgtccggcga aggagagcag cgcgtgggcg ccctccagga aggcgtcgga
     1321 gagcgccggg ccggcggggg tgcggacgaa ggcgtcctcc agcaggtagt gcagctggtg
     1381 gctgccgtct ccggagccga gaagcaggcc gagggaccgg aaggcctcga cggtgaggcg
     1441 gtagccgccg gggagttcgg ccgggcgctc ggcgaggtgg gccgcgatcc ggcgggcccg
     1501 ctccacgtcc atcgggtacc gcgcgtagtg ggccaggttc ttgcgctcga tgcgggggta
     1561 cgcggcctcg tacacctcgt cggcggtggc ggtcagggac gggagtccgc cggtgatcag
     1621 ggcggcgctg aggccctcgg gggcggtgga gaggtagtgg gtcgcgcaga atccgccgaa
     1681 gctctggccg agcacggtcc acggggcgcc gccggtcagg gcggggcgga tggcctcggc
     1741 gtcgcgcacg atggagtcgg agcggaaatg ggcgaggtac tcggcctgct gcgcgggggc
     1801 gccgcgcagt ggcagggtct gccggttgac cggggtggag cgtccggttc cgcgctggtc
     1861 gagcaggagg acgcggtagt cggccagggc ccgctccagc cacgcctgcc ggccgatgaa
     1921 ccgccgggcc ccgaagccgg gtccgccctc caggtagagc agccacggca gggtctgcgg
     1981 atccttgccg gaggcgacga cctcgcgggc gtacagctcg atgtgctcgc cgtccgggcg
     2041 cgcgtggtcc agcgggacgg tgaaccggtg gtcggtgagg accgttccgg gctggcggta
     2101 gctgtgctcg atggtcacgg acggcccctg gggtacgagg tacggaagac ccgtgccccg
     2161 gccgggtcgc ggcaggggca cgggtgtggc gttccggtga gtctagtacg ggtcccagca
     2221 cgggcccggg gcttacggga actcgaccac cgagcggagc acctcgccgc gctccatccg
     2281 ggcgaaggcg gcttcgaccc cgtcgagcgg gatggtctcg gagacgaagg cgtccaggtc
     2341 gagccggccc tgcaggtaga ggtcgacgag catcgggaag tcgcgctcgg gcaggcagtc
     2401 cccgtaccag gaggacttca gcgccccgcc gcggccgaag acgtccagca gcgggagttc
     2461 gagcttcatc tcgggggtcg gcacgccgac caggaccacg gtcccggcca ggtcgcgggc
     2521 gtagaaggcc tgccggtagg tctcggggcg gccgaccgcc tcgatcacca cgtcggcgcc
     2581 gttcccgtcg gtcaggccct ggattgcctg gaccacgtct tccttacggc cgttgacggt
     2641 gtgcgtggcg cccaggccgc gcgcccactc cagcttccgg tcgtcgaggt ccaccgcgat
     2701 gatcttcgag gcgcccgcca gccgggcccc ggccacggcc gcgttgccca ctcccccgca
     2761 gccgatgacg gccaccgagt cgccccgccc gacgttgccg gtgttcaggg cggcgccgag
     2821 gccggccatc accccgcagc cgaggagtcc ggcggccgcc ggtgcggcgg ccgggtccac
     2881 cttggtgcac tggccggccg cgaccagggt cttctcggcg aaggccccga tcccgagcgc
     2941 cggggagagc ggggtgccgt cctccagggt catgggctgg gtcgcgttgt gcgtggcgaa
     3001 gcagtaccag gggcgtccgc gcttgcaagc ccggcaggtc ccgcacaccg cacgccagtt
     3061 gaggacgacg aagtcgccgg gggccacgga ggtgacgtcc ggtccgaccg attccacgat
     3121 cccggcggcc tcgtggccga gcaggaaggg gaactcgtcg ttgatgccgc cctcgcggta
     3181 gtgcaggtcg gtgtggcaga ccccgcaggc ctggacccgg acgagcgcct cgccgggtcc
     3241 ggggtcgggc acgaggatcg tcgtcgtctc caccggtgcg cccttgctcc gggcgatgac
     3301 ccctcgtacg cgatgcgtca cgtcgtaacc ccgttctgct ctcattggtt cccgctcaga
     3361 acgtacacgg gcgccgcgcg gtacgggagt tgcctcactc cggggcgcca tatccggcca
     3421 gctcaggggg tacggacgcg cgcagggcgg cgccgaacgc ggccaccgcc gggtgggcgc
     3481 cggctccgct gcggaaggcg agattggtac ggcgctgcat gcgcaggcgg gtgaggcgga
     3541 cggccgggcc ggcggggccg gtgaccccga gctgcggtac gacggccacc cctgcccggc
     3601 cgcgaccagg gcgagcacgg tggcgaactc gtcgacctgg tggcgcaccc gcgggctgaa
     3661 cccggcggcc tggcaggccc gtacggtcat ggcgtggcag agggtgccgg gggttgcggt
     3721 gatccagggg tcctccgcgt gcgcgcgcag gacggcgttc tggtcgtccc ccgggggtgg
     3781 ttcggggaac cccgccgcgg gcgcggccag gtacatcgcc tccccgtaca gcggctcggt
     3841 ggccagcccg ggctcctggg cggcgggcac gaagtcgtag gcgtggatca gggccacgtc
     3901 gaggtcgccc gagcgcaggg cgtgcgcgac cgccgccggg tcggtttcgc ggaccatcgg
     3961 ctcgagtccc gggtggcgcc gggcgagggc ggtcagggcg gccgggacga tggcccgggt
     4021 ggcggtgggg aaggccccga tgcgcagggc tccggccagg cctccgcgtg cctcggcgag
     4081 atcggactcg gcttgttcca gccgttcgag aacggcctcg gcatgtccca ccaggtgctg
     4141 cccggccggg gtgaggcgca cccggcgtcc ggtgcgttcc agcaggggca gcccggcttc
     4201 gcgttcgagg acggcgagtt gctgggatac cgccgaagga ctgaaggcga gggcttcggc
     4261 gacggcggcg atggtcccgc ggcgggccag ttcgcgcagc agtcgcaggc gtcgtacgtc
     4321 gagcatcggc tcagcttacg ggtctggtaa gaaatgcgaa ctggatctgt cgggtctgcc
     4381 gggccaggct ctacggcatg gcacaggaca ccactcagaa cccggctcgg gccctctcgc
     4441 ccgccgccgc ctccctccac gggatccacg taccgctcgt cacccccttc gaccgggccg
     4501 gggaggtggc cgccgaggcc ctcgaggggc tcgcccacga ggtgctcgac gcgggcgcca
     4561 ccgggatcgt cgccctcggc acgacagcgg agagcgcggc cctcgacgag gcggagcgcg
     4621 acctcgtcac cgacgtgtgc gcccgggtct gccgggagcg gggcgcgacg ctgaccgtcg
     4681 gcgccggggc gagcgggacc cgggccgccg aggcctcgct ggcccggctg acccggtggc
     4741 cgcaggcgcg ggcggcgctg gtgaccgtcc cgtcgttcgt acggcccgcg gcggcggggt
     4801 gctggcacac ttcgcgcacc tggccgaggt gagccccgta ccgctgatcg tttatcacat
     4861 cccgtaccgc acggggcagc cgctcgacgc atccgcactg cgggcgatcg gggccatccc
     4921 gggggtggcc ggggtgaagt acgcgggcgg gggcatcggc gaggacacgg tctcgctgct
     4981 cggtgacctg ccggacgggt tcgaggtgct ggccggggac gacgcgtacc tctccccgat
     5041 gctggcgctg ggcgcggcgg gcgggatcct cgcttcggcg catctggcga cggcccggtt
     5101 cgcggagctg gccgcggcct ggcggtcggg ggacgtggcg cgggcgcgca cgctggggca
     5161 cgcgctggcc cggctgtccg cggcggcctt cgccgagccc aacccgacgg tcgtcaaggg
     5221 cgcgctccac gcgctggggc ggatcccgac gcctgacgtg cggctccccc tgctgccggc
     5281 ctcggaagcg gcggtggcgg tcgcgctgga gcgcctggcg gagctccaga gctgagaatt
     5341 acgcgccggg aaacatccgc gatgggcgat ttacccccta cgcgcgagtc gcccgaatga
     5401 ggcccccgga gagccgagtt gcccgtattg gccgcagagc cgccggcccg tgatgtgagt
     5461 cacgccggat gcgccaacat catttccccc gggaggccga tccccttttc ccggaaaggg
     5521 aatcggctat tgcacagaga cgccgacaag gtcatttacc ggacgtatag cgggaagtcg
     5581 atctaccggt ggaattgggc tcttgttccc gcccggcggg ctcgcttacg gtcacctcgt
     5641 tcctggtggt acgcagccga atccggcccg cctcccggga tctccgtccc cccacgtgag
     5701 gaattccgcc atgcccgcaa agggaaagca ccgccggccg aagcaccacc cgatcacccg
     5761 caagctggca ctcgtcggca ccggtggcgc ggccctcaca ctcccgctga tcagcgcgac
     5821 caccgccggg gcggtggcga cgaccaccgc ccccgcagct cacaccgccg cccccgcggc
     5881 ccccaccgcc actcccacga cctattccgt ggtcgccggc gacacccttt ccgagatcgc
     5941 cgcggaccat tccgtgagcg gcggctggaa gaagctctac gcggcgaacc ggagcgtcat
     6001 cggcgacaac ccggcgatca tccggcccgg tatcaagctg aacctcggca cccaggacga
     6061 gaccgcccgc gcgagcaggt ccgccgcccg gcccgccctc gcgccggccg ccaagcccgc
     6121 ctacgcgaac aatctcgacg gatggatccg cgagtccctc gacgtgatgg ccaagcacgg
     6181 aattcccgga acctacaacg gaattcaccg caacgtgatg cgggagtcct cgggcaaccc
     6241 cctcgccatc aacaactggg acatcaacgc ccagaacggg atcccgtcca agggcctgct
     6301 ccaggtcatc gacccgacgt tccaggccta tcacgtgccc ggcacctcgc aggactccta
     6361 cgacccggtc gcgaacatca cggcagcctg caactacgcg gcagcccgct acggttcgat
     6421 cgacaacgtc aacggggcgt actagaaacg ctcagagcca gccctggcgg cgggcggccc
     6481 gaacggcctc catgcggttg cgggtgccgg tcttgccgat ggccgaggac aggtagttcc
     6541 tcaccgtcga ctccgacagg tacagcttcg cggcgatgtc ggcgacggtc gccccgtcca
     6601 ccgcggcgtt caggacgtcc acctcgcgcc gggtcagcgg attcggtccg gcgccgagcg
     6661 cggcggccgc gagcgagggg tcgatcacgg tctccccggc gagcacccgg cgtatcgcgg
     6721 cggccagttc ctccaccggc ccgtccttca ccaggaaccc ggcggctccg gcctccatcg
     6781 cccgccgcag gtagccgggg cgcccgaagg tggtcaggat cagcacgcgg cagccggggc
     6841 accgcgtgcg cagctcggcg gcggcgtcga ggccgctgcg gcccgggagt tcgatgtcga
     6901 gcagggccac gtcgggccgg gcctccagcg cggcgggcac gatctcgtcc ccggcggcga
     6961 cctgcgccac gacctcgatg tcctcctcga gcccgagcag cagggccagc gcgccccgca
     7021 tcatgccctg gtcctccgcc agcaggaccc tgatcatgcg cgctcctcaa tcccttgtcc
     7081 ggccggctcc agcggcagtt ccgcggtgac ccggaagccg cggcccggga cggggccgct
     7141 gcgcagggtg ccgcccgcca cggcgaggcg ctcggtgagc ccggtcagtc cgctgcccgg
     7201 cgcggtcgag cctacgccgc ccccgtcgtc cgtgatcacc agccggacct tctcggcgga
     7261 gctccgcagc tcgatctcgc acgtgtcggc gccactgtgc cggacggcgt tggtcacggc
     7321 ctcgcggacc acccagccca gcagcgccgc cgcctgcggg ggcagcgggg gcccggcctg
     7381 ccgtacgacg ggctcgatcc cggcggcggt cagcgcaccc cgggcccggt cgagctcggc
     7441 ggccaggctc gcctcgcggt acccggtgac ggcctcacgg atctcggtga gcgcctggcg
     7501 gccgacggac tcgatgtcgc ggacctgctc cagggccgcg tccatgtcgc gcggagcgat
     7561 ccggcgggcc gcctccgact tcacgacgat caccgacagg gtgtggccga gcaggtcgtg
     7621 cagatcacgg gagaaccgca gccgctcctg gtccacggcg gcccgcgcca gctcctgccg
     7681 agtgtcgcga agttccttca ccgtctcgga cagggccagg atggccgcgg tgaccatgcc
     7741 ggacaggaag gtcccgtaga cgatgccgag tgcgtcccag ccctgctgca gccccgcgat
     7801 cactccggcg agggccgtga cgccgaacat caccgggccg agccgccggc cccggaccac
     7861 cgcgccggtg gcgaggccca gcagcgggaa gaacagcagc cagttgtctc cgtaggcgat
     7921 ggcgagggcg caggtgaccg cgcccagcgc gatcaggcac cagcgggtgc tccgcgcctc
     7981 ccgcgccggc ttgtggaagg cgcggaacac cagggtgatg tagagggagt tgaagaccag
     8041 caggcccagg ccgccgatcc aggggttggg tgtctcgccg tggacgacgt tggacatcgc
     8101 tcccatcccc aggagcagcc agggcagcag ggtgaaggca ctgggcgggc ccaccgggcc
     8161 gtgcccgcgg ccttgaccgc agccttgacc ttggccttga ccttgacctt gatcttgcat
     8221 ccccgttccc cgcttcatga gttacgccgt cctcgcggac cgacggtacg agagcaccgc
     8281 gtacgagccg aacaccaggg cccacaccgc gaccaccgcc accgcgacgg ggccgggggc
     8341 cgcgccggtg gcgacggact ggccgatctc ggcgaagcgg cgggtcgggg tgagtccgga
     8401 gagggagcgc agccactgcg ggaacagctc gacggggaac cagaggcccc cggccacgga
     8461 gagcgcgagg ctgcagccca cgttgacgag cccggtggtc tgggcggtga gccggtagcc
     8521 gttgcccagg ccgagcaggg tgaaggggaa cgcgccgagc cagagcacga ggatgagtgc
     8581 gccccactgc caggcctcca tccggacgcc gttgacgacc gctcccgcgg cgagcaccgc
     8641 ggcgatggcc ggcagcacga tcaccgagcc ggtcagcgcc cgcccggcca ccacctgacg
     8701 cggggtcatc ggggtgaccc gcaactggcg gagccagccg acgcccttgt cctcggcgac
     8761 gccggtcccc gtcgacaggg ccgcacccaa ggccccgtag gcggccatgg ccaccatgga
     8821 ggcggtcctc cactcggtcc cgctgctgcc caggttggtg aacatcaggt acatgagcac
     8881 cggcatgccg atgccgaaga cgacgaaggc ggtgtcgcgc agggtgcggc ggacttccag
     8941 gcggacgtag gcggtgatca tcgggcactc cccgcagcaa tggtggggcc ggtgacgccg
     9001 gcctcggtca gggcgaggaa ggcctcgtcg agcgagggcg cggtgacctc gatcccccgg
     9061 acggcgccga ggccggcaag ggcgacgacg gtggcgtccg gatcctgagt acgcagccgg
     9121 gcccggtctc cccgtacctc tacggagacc accccgggca gcgcgccgag gggcgcggag
     9181 gagtgcccgg ccaggtcgaa ggagaccagt gacccgcccg cggcgcggcg cagttgctca
     9241 cccgtgccgt cggcgacgat ccggccgcgg tccacgacca cgatccggtc ggcgtgggcg
     9301 tcggcctcct ccaggtagtg cgtggagaac aggacggtgt tgccgcgccg ggcatagccg
     9361 cgcatggacg cccagaaggc ccggcgggct tccacgtcga gggcggcggt cggctcgtcc
     9421 agcacgatca gctccgggtt gccggcgagg gcgacggcga agcggaccct ctgggcctgg
     9481 cctccggaga gccggtcgat gcgccggccg gcgagggcgg tgagaccggc gagttccagc
     9541 gcctcggcga cgggcatcgg ggccggatag gtccgggtga cgaaggctat gagctcccgc
     9601 acggtgatcc gcgggacggc cctcccctcc tggagcatcg cgcccacccg cccggcccga
     9661 acggcctgcc cgggggtttc gccgaagagg cgcacgctgc ccgcgtcggg ctcgttcagg
     9721 ccgagcagca ggctgatggc ggtggacttg ccggcgccgt tgcggcccag cagggccacc
     9781 gtctccccgc gccggatgtc gaggtcgatg cccgcgacgg cgtggacggg tccgaaggat
     9841 ttggcggcgt gccggaaccg gatcgcgggc cgctcgcccg gcgaagtctt cgtcgtctgg
     9901 gtcatgtcca ccacgctagg gagcggggcc gctcccccgg cagatgcgcg tgtacggaca
     9961 ccggcagtac aaatgtcacc gctcccgcgg ggctacgggg ctacggggtg cgggagcgca
    10021 ccccggcccg ggccctcagc agggtgcgca ggggggccac caggccatag ccggtgtccc
    10081 ggcgcagggc cgtgatgccc gcgcgctcca cggcggtcag ctgttgggcc atcagctcct
    10141 tcatcgtcgc ggtcacggga cgcagcccgg gatcggcgag gtcgaggatg ccgtcggtgg
    10201 cctcgagggc ggcccgggca cggccggtct cggcggcgag gagcgcccgc acggcggggg
    10261 tgtcgcgggc ctgttcgagg tcggcgcggg tcacggagtg ctcgtcgagg cgggcgcgcg
    10321 ggatgcagag acggccgtcc gccaggtccc cggcgaggtc cgcgaggaag tcgacccgct
    10381 gggcggcgtc gacgaaccgc cgccaggccg cggcctgttc ggggtccggc ccgccctggt
    10441 actggaggcc ggtgaagacc agcacccccg gccaggcgta ggcgtcgagg taggcctgga
    10501 actccgcctc gtcggcgaag ccgtcgaaac cggcctccgc ggtggcggcg ccttcgagga
    10561 accgggagac ccagtgcgcg ggcagggcgc gggagtccac ggcgtgcgcg taggcgcgca
    10621 gcaggggtcg gggctgtccc cggtcttcag ggcggcttcg acccgctcgg tcaacgcggc
    10681 caggttggcg gcccgttgcg ccggagtgcc ggtctcggcc acgtcgtcga ccaggttcat
    10741 gaaggcgagg ccggcggcga gccagggcac caggggcggc gcggcgagca ggcgcagcgc
    10801 gaggtacggg gcgggttcgc ggcggagtac ccggcgggcg gcgtgggtgt agtcctcccg
    10861 cagccgggtg ccggatatcc cggcggccgt gagtgtggtg cgccagctcg gcatggtggt
    10921 cgtgctcctc ggaacgggta cgaaggtcag gatcgcagac gccgggcggc gggcagcggc
    10981 cgcctcagga gcggtagacc ttcctgacct tgccgtcggt gccggccagc acgtagccgc
    11041 cctgcccgta ctcgtcgctg aggtagggcc gcatggacgg gctctggtcc agcatccagg
    11101 gctcgacgat cacgtagcgg gtggtcgggt tcgccacgcc caggtccttc ttggcctgct
    11161 ccaggagggc gggcagggtg tcccattcga ccgtggccat gtcgatgagc ggggcgcggt
    11221 ccttgacggt gccggcgggg ccggtgcggg tgaccccgcc gtcgcggtac tgccaggagt
    11281 cgacggtctt ggctccgggg gcggtgggga cggatgctat gacgtagtcg tcgtagatcc
    11341 gcaggttcac gaagctggtg gtgccggtct gctgcttcag ggccgccagc gcggtccgga
    11401 tgctggcggg ggtgagcagg ctgccctggg gggcctcgcc cttgctcgtg ctcgccttgg
    11461 ggccgggggt cgagggggcc ggggaagttg cggggccggc gctgccggtg gggccgctgc
    11521 tgatgccacc cttcgcgtcg ccgccggagg cggagccgtc cgggagccac ttgacgatcc
    11581 cgaccgtccc ggccacgagg accgccgcga gggcggcgcc gagcaggacc gggcgcctgc
    11641 gcggggtcgc gtccgccggg aggggcgcgg tgaccgcgta cgggtggggc accgggccga
    11701 acggcggcgg tgtgggcggc ccgtactgcc ccacgaccgg cggggccgcc tggcccgccg
    11761 gagccgtggc gagagcggtg ctcgcgtccc ggagcagttg ttccagctgc tccgcgtcgg
    11821 gccgcgcggc cggatcccgt acgagcagcc gttcgagtac gggcgccagc gggccggagc
    11881 gtacgggcgc cgggatcggt tcgtcgagca cggccaccac ggtggccagg ctggtggccc
    11941 ggcgcagcgg gtggacgccc tccgcggcca cgtacagcag catgccgagc gaccacaggt
    12001 cggaggcggc cagcccctcc tccccgcgga cgcgctcggg tgcgatgtac tccggcgagc
    12061 cgatcagcac accggtggag gtgagtccgg tcgagccgtg cagggccgcg atgccgaagt
    12121 cggtgagcac cgccgatccg tcggggcgca gcagcacgtt ggccggtttc acatcccggt
    12181 gcaggacccc ttcggcgtgt gcggcgcgca gtgcggacag gaggtcgagg ccgagccgga
    12241 gcacgtcagc cgtcggcagt gggccggacg ccagccggtc gtgcagggaa ccgcccttga
    12301 ccagttccat cacgatccac ggatgaccgt ccgtgccgac ggcgggctcg acgatgtggt
    12361 ggatcgtgac cacgtgcggg tgggcgaggc gagcgagggc ccgggcctcg cggacggccc
    12421 gttcgcgcag ctgggcggcg agaccgggct gggcggcggc ggtcgccggg tccggcgggc
    12481 gcacctcctt gagtgcgacc tcgcggtgca gtgcgatgtc gcgggcgcgc cacaccgttc
    12541 ccatgccgcc gctgcccagg ggcgcgacca gctcgaagcg cccgtcgatc ggctgtctgc
    12601 cagcctcact cgtgtccatg gccggtcatc gtaagggtcg cggacgtcag cagcgtcggc
    12661 ggtccgccgt gaggatgccc tgcacggtgg tgaccgtacg gtcgtagcac ccgccggggg
    12721 cctgggaccc gtacaggcgg gagcgggcgg aggtggtggc gaccgcgtgc cgctggtcgc
    12781 gcgggacgtt cgcggtgtag gtggcgtcgc ccgtgtagcg gtcgtcgagc cgggagatgt
    12841 cggtcttccg gccgccgcgc agggtggcgg tgtccgcgcg gtcgccgagc gagaggacgg
    12901 tgcgcagccg gtcaccggcg ccgagggtgg tctcgccgtc catcgtgtag gtgcggtggg
    12961 tgcgggtgcc ggtggccccc gggtcacggt ctcctcgtcg gtccaggtgg cggtgagcgc
    13021 gtcgcggttc tcgccgtcgg tccagcggtg gacggaggtg ccccgcacgg cgcgggtgac
    13081 ggtggtggtg acccgcccgt gggaggtgtc gaggtgtccg gcgacggtca gccggtgacc
    13141 gccctcggtg tcgaggcggt gttcgccgcc gggtgcggcg ggggtccagc gggaggagtt
    13201 ggccggggcg ctctgctcgt tccgggtcag ggcgccggtg acgacctccc gggcctcgtc
    13261 ctgccacagc agcaggttgg tgggggtgct ccagccgctc tgcccggccg gcaccccggc
    13321 cacggacacc tcgatccggt gcgggcggcc gtcgttgagg agcgcggcgt agggggtcag
    13381 gtcgtagcgg atcggctgga cgtcgaaggc gcggaggccg ggggtgacgt accagaggaa
    13441 ggggttggac cagccgccgg tccagacggt ggggaagggc gcggcgatgc cggcgagctg
    13501 tccgtccacg gagacgcgga cctcgcggta ggggccgtcg gcggccttgc aggagtacgg
    13561 ggccgcgtcc ggggtggtca tgtaccagta ctcctcgcag ccgccgcccg agccggtggc
    13621 gtacacctcg gcgacgaggc gctccgtgtt gcgcggggtg gtgacggccg gggtggtgag
    13681 ggggaggacg cggtcggggg tctcggcggg gccggtgcgg ccttcggcgg cgtagaaggt
    13741 gagggtgacc ttgacgtcga tgacgccggt gtaggtgtcg ttgacgacgt tgccgatcag
    13801 catctcgacg ggctgcgggc gggcgagggt gtcgcggtag cgcgtgacgt ccttctcgac
    13861 ggaccaggtg atgccgtcgg gcgagggctg ggggtggagg tccgcaggat ctcgacgccg
    13921 ccgagggaga ggtggccgag gcggtcgtac tggcggccct tgactttgcc gtcgaggcgg
    13981 agcaccaccg cggcccagtg gtcggcgccg cagccctggg gcggggcgta gttgccccgg
    14041 tagggggtga agtcgcggaa ctgcgcctcc gcgagggtga cttcgcagga ccgggtcccg
    14101 ggccgggcca cgggtgggcc ggcggtgagg gggtcgtgcc agtcggtgcc gaactcggcg
    14161 ggcggtgttc cgcctccggg cgcgggcacg ggggcggcgg cgttcgcggg tcccgcggtg
    14221 ccggccaggg tggccgcggc gagggtcagc gcgccgagca ggcccatgat cctgtgtcgt
    14281 ctcatgggcc agcagtgaaa ccggaccgtc cggccggcgc cagggctcgc gccccggccc
    14341 tggcctgatt tcgccggtca ggcgccggtc ggaccggtcg gaccggtggg gccggcagga
    14401 cgacgactca gtcgcgggag ttgccgaaga ggatccggta gccgatcagc aggaccagcg
    14461 agcccgcgat ggcggagccc caggtggcga cgtcgaagaa ctgggtctgg atcggccggt
    14521 ccaggaactt cgccgagagc cagccgccga tgaaggcgcc ggccacgccg atgagggtgg
    14581 tgccgatcag gccgccgggg tcccggccgg gcagcaggac cttggctatg cctccggcca
    14641 gcagtcccag gatgatccag ccgatgatcc ccatgtccat gcactccgtt tcggtgttcc
    14701 ggtggttctc cagggaggac gcgcccgggg ccgaaacggt tctccgtacg ctcagcggtg
    14761 gtgggccggg gtgagcgcgc cgagcggtgc ggcgggcgac gggacggaag ccgggacggg
    14821 cggcggcgcg ggcggcgtac gcgtcagcag gaggaccccg cgcgccgcgg ccagggctcc
    14881 ggccagggcc agcagcactc ccgccgcgcc gccctggagg cgttcgccga gcaggaccat
    14941 gccgatcgcg gccgcggcca gcgggttggc caggttgacc acggcgagcg gggcaccgag
    15001 cccgccccgg taggcccgct gcgacagcag catcccgccg acggcgaaca ccacgacgag
    15061 cagggccacg gcgacgaccc ggacgctgaa cagggatccg ccgcggcccc cgccacggcc
    15121 acggtctggg tcagggccga ggcggccgcg gaggccagcc cggaggccgt ggcgtgccgc
    15181 agccccgagc gcgggtcctt ggcggcggtg agcaacagga tcacggcggc cgtggccccg
    15241 gagacggcga gcgcctcggc cagggtgagg gtgtcgtcgg gggccggccc ggaggccggg
    15301 agcagcagca ggcccagtcc cgcgacggtg gccagggtgc cccgccattc ggtggcggcc
    15361 acccggcggc cggatccgcg cgcccccagc gggacggcgg ccacgagggt cagcgcgccg
    15421 agcggctgca ccagtgtgag cggtccgtac cgcagggccg ccgcgtgcag cagggccgcg
    15481 gcggcgttga gtccggccga ccaccaccag gcaccgttgc cgagcagtgc cttggcgctg
    15541 cgcgcggctc cggcgcgggc gagccgctcc tgggcgacgg cggcggccgc gtaggccacg
    15601 gcggaggcga ggcagaggcc gacggcgagg gcggtggcgt tcaccgctcg gcccccacgg
    15661 gcacggcggc gcgccgcgga cccggcagct cggccacggc ggtgccgatg gggccccggc
    15721 gcgggatgag cagcaggacc acgccgagga gcagggtcgc cacgatcgcg tcgagccagt
    15781 agtggttggc ggtgccgacg accacgagca gggtcagcgc ggggtgcagc agccacaggg
    15841 cgcgccaccg gccggaggtg gcggcgatca tgccgagcgc gagcatcagc gcccagccga
    15901 agtgcaggga gggcatcgcc gcgaactggt tggccatggt gtcggtggcc ggcgcggccc
    15961 cgtagacgct gggtccgtag acctggccgg tgtcgatcag gtgcgcggcc tcgagcatcc
    16021 gcgggggcgc gaggggaagg ctaggtgcag ggcgagggcg gctccggtga gcaccgcgag
    16081 cacgcggcgg gcccacaggt agtggtcggg cctgcgcagg tagagccaga tcaggaagag
    16141 cgcggtcgcc gggaagtgga cggcggcgta gtaggtgttg gcggtgtgga cgagggtgtc
    16201 gccgtgcagc agcaggcgct gcaccgctcc ctcgccgggc aggtgcaggg cgcgctcggc
    16261 gtcccagatc cgcgcggcgt tgcggaaggc ctcctcggtg cgtccggtcg agagcatccg
    16321 gcccgccttg tagacagtga acagccccgc gacgagcagc agctcgcgta tgaggcggcg
    16381 gcgagcggcc ctccgggcgg ccgccgcccc tgcgggtgtg atgtgggagg tcatcccccg
    16441 gtctctcttc ctgttgcgca cagatcgaca cgccagtgta tcgatacatc cgcgtatcga
    16501 tacgatcgtg tagcgatacg ctcgcgttcc cgtacactcg cactggaaga tgccgccgag
    16561 gcgcccccga ggagagccgc accccatgac gtcgacgccg accaccgcgc gccgctccaa
    16621 gatcactccg gagcgggagc aggagttctt cgacgccgtc ctggagcagc tgcgcgagca
    16681 cggctacgag gccctgacca tggagggcgt cgccgcgcgg gccagctgcg gcaagtccac
    16741 gctctaccgg cagtggaaga ccaagcccca gctcgtcgcc gccgccctgc gcgcgaaccg
    16801 gcagggcacg ctcgtcgcgg tggacaccgg gacactggcg ggcgacctgc gcgaggcagc
    16861 ccggatcgcg gcctgcacct cggggcgcga cacccggctc acgcaggccc tcgggcacgc
    16921 ggtgctcagc gacgaggaac tgcaggccgc gctgcgcgag gcgctggtcg agccggagct
    16981 ggccgccttc gccgtgatgg tggagcgggc ggtggcgcgc ggcgagatca ccgcggacca
    17041 cccggccgtg gagttcctgc ccgcgcagct gatgggtgtg ctgcgcatcc ggccggtgct
    17101 cgaagggcgc tacgccgacg ccgactacct ggtccggttc gtcgacgcgg tgatgctccc
    17161 ctccctgggc ctcacaccgc ccgggacccc cgggatcccc gggaccccct gaaccggcgg
    17221 gccgccgtcc cgatgaccgg acggtgacct gcccgcgctg cctcgtgggg acggcggcag
    17281 cgcgccaccc ggaccgggcg gcggtcactc actcgaggag tgaccgccgt ccgatctgat
    17341 gggcccccgg gcgtatcagc ccgtcgtcag cgaactgcgc ccatggtgcg ggtgaactcc
    17401 tccgggtcgg cgtcgaagcc ctgcaggcgg gcgtcgaggg accaggatcc cgagtcgtcc
    17461 cgggtgaaca ccgcgaccgt ggcggcagtg gcggacggga tggcgtcgaa gtcgccctgg
    17521 gcgaggtcgg tgtgcccctc gcggatccgg acccccgtac cggcgatgtc ggcaaaggtc
    17581 gcgcgccgcc caccggtgtc ctgaatgagc accccgacca ccacgcggtg caactccgat
    17641 gccatccggt cgagttcgag ggtcatcacc tcgtcgaagc cgaagccctg gcccgtgtgg
    17701 ctgtcccggt tcagggtgat ggtgccgtcc ggtgaccggc tgccgaagtg gaccaggtgg
    17761 acgggtaccc cgtgcaggtc cgcggcgccg tacaccgcgg ccacgatgtc gaggtcgtgc
    17821 gcgggccgtt cggcgggact ggggtcccac cgcagcgcga cctcgacctt ggccagaccc
    17881 ttgcgtacac cggtcaccga actccccctt cgcttacggg tattgcccgg ccatgttccc
    17941 acgtgtcccc cgccgcggtc cgaacgaccg tacgttcccg gccagtgcgt cgctcatgtg
    18001 gcgaggtcga cgcgtacggt ctccacccag gccgggggcg cgggcgggtt cgccccgacc
    18061 agcgcggcga tcagccggca ggacggtgtc tcgtccggcc acggcgtgta cccgtcggtc
    18121 agcacgacga cgacgttcgg ccggtcgggc agggccagcg cggcgccgat gccgacccgc
    18181 atgtccgtgc ccccgccgcc cgccagggtc acctcgcccg cgcttctcac ccgggtcacg
    18241 gcgtgtacgt cggcgtcgca ggccagtacg gcgacccggt tgccgccgac ccccacctcc
    18301 cgcaggacgc cggtgacttc ggccagcgcg gccgcgaggt cgtccgggcc catcgacccc
    18361 gaggtgtcga tgacgatcgc cacccgcggc agcggcctgc gcaggctggg cagcaccacc
    18421 cggccgccga gcgcgggagt gcggcgcgag gggcggcggt acgtgtagtc caccgcgccg
    18481 gccgcccagg cggcggcctc gcggaccgct ccggacaggg cgcggcgcca gtcgacggtg
    18541 ggctccagca gctcctgcgc ccaccgggcc cagcccgcgg ggatggtgcc ccgggtgcgc
    18601 tgctgggccc gtacggcctg ggcggtctgc cggcgcagcg cctccgcctc caccgggccg
    18661 acccgggcgg ggcccccgtc ctcgccgagc tcccagggca tgggggtgcc gtgcgcgccg
    18721 gatccgcagt cgaccccgtg gggcgtgggc gggatcgcgg gcaggtaggc ctcgaacagg
    18781 ccgccggtgg ccaggccgaa gagcctgggc tccatccgcc cctcgggcag cgccagcccg
    18841 tcggcgagca ggtcgtcgtt gatctcgcag tcctgggcga tgttgacccg gaccggatcg
    18901 cgctggtcgg cggcgggcag gcgctcggcc cggccgtggt ggtcgcgcag caggtgcgcc
    18961 acctcgtgga tccacacccc ggccagctcg acgaccgggg tcgcctcgac gaaggccggc
    19021 gagacgtagc agcgccagtg ccggtcgacg cccatggtgc gcacgccgtc cgaggggacg
    19081 accgtgaggg cgtacagggc ggaggcgagg tacgggcggg cttcggcggc cttgtagcgg
    19141 gctgccagca gcttcgcgcg gtccaggctc acggcggggc cgggctcagc cgccgcccgg
    19201 cagggagccg gacagctgga gcagttccac gaaggcgtcg atgccggcgg gcacgggcca
    19261 gtcgaggtcg cgcatcgcgg cgaggtcggc ggcggcgcgg gcggccacgt cgggcacgcc
    19321 cgcgtccacg gccttggcca ggacggccca gcccgcctcc cagcgggggc gggtgagctc
    19381 gctctgcacg gccgcgacca cggcgatgag gaaggccagc tgccggtcgc cgcgttcggg
    19441 cagggcgaag gcgtccgggt cggccagcac ccggtccggg tcgggcaggt cgaggtgttc
    19501 gaggtacgag agcagttcga tcccggcggc ttcgcccacg gccccggtga gcgccatggc
    19561 cagtgcctcc cggcccgtcg aggccgcgta ccccgtggcc agcagccgca gggccatctc
    19621 ccaggtgcgc ggggagggcc agccgcggcc ccgtgcggcg gcctcggccg gcatgtggtg
    19681 gaccaggccc ggccgggcgg tgaggaagcc ggagaccgcg ccgcgggccc gggcgacaga
    19741 gccggaggcc ttggcgggat cgacggccgg gatcgccacc tcgggccagg tgccggccat
    19801 gccacgggcc acggtgcgcg ggttgtgcgt ccagtcgagg tggacgaagc ggttggcgag
    19861 cggcgggctg aggtgccagc cgtcggccgc gctggcgggc ggattggccg cggcgacgat
    19921 ccgtaccgcc gccgggagtt cgtggctgcc gacccggcgt tccaggacca cgcgcagcag
    19981 ggccgcctgc acggcgggcg gggcggagga caactcgtcg aagaacagca gcccgtggcc
    20041 ggtccgggcg aggcgcaccg cccagtccgg cggggccatc gggacacccg tggtggcggg
    20101 gtcctcgccg acgatgggca gcccggcgaa gtcggagggc tcgtggacgc tggcgatgac
    20161 ggtctccagc tccacgccga gcgcggtcgc gagctgctgc atgccggcgg acttgccgat
    20221 gcccggctca ccccacagca ggacgggctg attggccgtc acggccaggg ccagtgcctc
    20281 gagttggggg ttggtggcgg gttcggtgcg gatggcgctc agccgggcgc ccagggcgtc
    20341 ggcggcggcc agggcccggg cgggctgcgg ctgggcactc atgcgtcctc gtcctctccc
    20401 tcgtccatgt actcgtcgaa ccagtcggcg ccgatgccgg ggaactcctc gtcgacccgc
    20461 tgccgcagga aggtgaggtc cgtgcgcttg tagcggcgga tctcctggga cagcgacagc
    20521 tccatctcgt cgacgacgtc gatccgggag ccggccgcca gcagggccct gaccagatcc
    20581 gccgaaccgc cccagtgcac cgcggagtgc agcggggtgc gctcgtgctt gtcccgcgcc
    20641 tccaggtcga gtccggccgc gagcagccgg ggcagcagca cttcgtggtc gagcaggtgg
    20701 agttcgtgca gcagtccgcg tccgcgggcg ttccggatcc gggggtccac gcccgcgtcc
    20761 agcagcgcca cgaccgccgg ggtgtccccg tgctggacgc gcaggaagag ctcccgctgc
    20821 tgggcccgca gggcgcgcgg cagccgcccc tcgcccgtgg tccaggtctg ctgcacggcg
    20881 aagcacccgg agaccgcgcc gccgaa
//
