LOCUS       NZ_CP102332            23531 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptomyces changanensis strain HL-66 chromosome, complete genome.
ACCESSION   NZ_CP102332
VERSION     NZ_CP102332.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces changanensis
  ORGANISM  Streptomyces changanensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6817869)
  AUTHORS   Wu,H. and Han,L.
  TITLE     Streptomyces changanensis sp. nov., an actinomycete isolated from
            soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6817869)
  AUTHORS   Wu,H. and Han,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2022) College of Forestry (Academy of Forestry),
            Northwest A&F University, Northwest A&F University, Yangling,
            Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.9; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 187.45x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024600715.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 19:18:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,071
            CDSs (total)                      :: 5,982
            Genes (coding)                    :: 5,812
            CDSs (with protein)               :: 5,812
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 170
            CDSs (without protein)            :: 170
            Pseudo Genes (ambiguous residues) :: 0 of 170
            Pseudo Genes (frameshifted)       :: 70 of 170
            Pseudo Genes (incomplete)         :: 131 of 170
            Pseudo Genes (internal stop)      :: 9 of 170
            Pseudo Genes (multiple problems)  :: 37 of 170
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:13:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2212017
            Orig. end                         :: 2235548
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102332.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23531
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="7"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23531
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23531
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13531]"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13531
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(310..1638)
                     /locus_tag="NRO40_RS09825"
                     /old_locus_tag="NRO40_09825"
     CDS             complement(310..1638)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.5"
                     /locus_tag="NRO40_RS09825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09825"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_157901929.1"
                     /sec_met_domain="Pkinase (E-value: 3.1e-29, bitscore:
                     100.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGASDSSIKAQERYRLGARTLGHGSYAQVFPAVHKKTGEEVALK
                     RAYNRQDAQDRIKREIQDQKRLAHPNIMPILDHDPGFTWYTMPRAVGNLKDLRQGPDEE
                     ELASILLAIGEALDVAHQLGLVHRDISPQNILALSGDSGARYRWVVADWGMVRRPPEEA
                     SRILTRTGQGMGTPGYDAPELSVDPRKATPAADVYSLGRVAAWYLTGTSPASGVRLLPD
                     GEFLHWRLFVNACTRQETSLRTQTMSELRDMVQVVLNDRDEPVLTKARRLVEGITLGQE
                     GSLEALVRLVDAHQDDASLYFDYFAQIPTGHTRAWCHSDPERAALLAGVLAKHLVAGSW
                     DDRDREYVSTPLAFLLTVLQALVGNNNLGHAQDLAPDFFAAELHWQDQDQRRRTLEWLG
                     DLQAPFDRALAPVLGARQDVVEYYREPGWRARSVVLATILGAS"
     gene            complement(2473..2775)
                     /locus_tag="NRO40_RS09830"
                     /old_locus_tag="NRO40_09830"
     CDS             complement(2473..2775)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577973.1"
                     /locus_tag="NRO40_RS09830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09830"
                     /product="hypothetical protein"
                     /protein_id="WP_058944648.1"
                     /transl_table=11
                     /translation="MTTANELRLLPWSGPDGKPCYLSTDDKDSYMSRLADNIEAVQLGT
                     AADLLVEAEETLGAGDADTEALRHVAQELTGALRDVLRIAISRGHRLTASEPHRL"
     gene            complement(2772..3515)
                     /locus_tag="NRO40_RS09835"
                     /old_locus_tag="NRO40_09835"
     CDS             complement(2772..3515)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577972.1"
                     /locus_tag="NRO40_RS09835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09835"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_058944647.1"
                     /transl_table=11
                     /translation="MTGPVASRHHEIADDLRNQIATSRIKPGERLPSEAVLASGYRVST
                     VTLRRALAVLQGEGLVEKIHGKGNFVRRPLRKIMYVGGWGMLDPWTAAEAALHITVRCA
                     TVRAHGHLAELLKVPAGSPLAEFFCVSHEGDAPHGLARIYIPRDLAPDGVLGDEPLCRE
                     AVTRFAVLSLPPAIVRETACARPPTPDEASTLRTNSTAPVLAITRVATDSTGRVVEAAF
                     LVFPGDRVDAVFTTHAMTDERQTRA"
     gene            complement(3512..3712)
                     /locus_tag="NRO40_RS09840"
                     /old_locus_tag="NRO40_09840"
     CDS             complement(3512..3712)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155143.1"
                     /locus_tag="NRO40_RS09840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09840"
                     /product="hypothetical protein"
                     /protein_id="WP_058944654.1"
                     /transl_table=11
                     /translation="MPAASIEVTAATVRRGDVIELGGLFCRVQDLFQLPHGAKQLIFES
                     GELLTMHARTRLVAVRMMGRR"
     gene            complement(3733..3933)
                     /locus_tag="NRO40_RS09845"
                     /old_locus_tag="NRO40_09845"
     CDS             complement(3733..3933)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029356.1"
                     /locus_tag="NRO40_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09845"
                     /product="hypothetical protein"
                     /protein_id="WP_058944646.1"
                     /transl_table=11
                     /translation="MKPRRQPHTTVAAIPYRSTACRIGTHPTCAEASPLSPPVDIPVVY
                     ERCDCLCHSTPDRFACAGVEQ"
     misc_feature    complement(4235..4249)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            complement(4254..4532)
                     /locus_tag="NRO40_RS09850"
                     /old_locus_tag="NRO40_09850"
     CDS             complement(4254..4532)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950159.1"
                     /locus_tag="NRO40_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09850"
                     /product="hypothetical protein"
                     /protein_id="WP_058944645.1"
                     /transl_table=11
                     /translation="MPASGVSAAGIAARLSALGLPARVQEHDRHTTVEAEVPGSLSADL
                     WRGVLQVVAEADRFGLLATSLNDRTLWAVVRKAVPTTGDVGGPSHQR"
     misc_feature    complement(4398..4400)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4550..4564
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.45"
                     /tool="antismash"
     misc_feature    4595..4609
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.6"
                     /tool="antismash"
     gene            4611..5232
                     /locus_tag="NRO40_RS09855"
                     /old_locus_tag="NRO40_09855"
                     /pseudo=""
     CDS             4611..5232
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028876.1"
                     /locus_tag="NRO40_RS09855"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09855"
                     /product="GntR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPEQPPYLRVADELRRRIAEHVWEPGDRLPSRAQIGQECGVGENV
                     VRRAQELLISQGVLEGRAGSGTYVAEPRQRVRMVRSAARERPDGSPFRVDMKALGKRGD
                     WESRTDAKVPAPADIAVRLGIAEGDPCVRTVVRVPGRRQADATGAEAGDRRGGVTSGHP
                     EVRARHPHPPDLLQRRGAAGGDGGHRGAGRPLRDRLRDPDHSSL"
     gene            complement(5283..5915)
                     /locus_tag="NRO40_RS09860"
                     /old_locus_tag="NRO40_09860"
     CDS             complement(5283..5915)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040391.4"
                     /locus_tag="NRO40_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09860"
                     /product="DUF6368 family protein"
                     /protein_id="WP_058944643.1"
                     /transl_table=11
                     /translation="MSGPTLVIELAEPLSPVALREFRALMVGVSSHFDEERPGCFDVNV
                     PAERLGVEDRRGEDWRKPFPLPLLDDTSADEGLRALVGFNPQREDWRRPFLVYLMGPGV
                     GDESIFEAEHADEPEVEAVLGFRPTHAVNVSAGCNREIDHVATALLTAAVMDVIGGVAK
                     AELLDGQAPVVAGLPGVLGIADDDWMALGTAEFLRAWAGHPAFRLVK"
     misc_feature    5893..5907
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     tRNA            6086..6167
                     /anticodon=(pos:2218145..2218147,aa:Arg,seq:tct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="NRO40_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="NRO40_09865"
                     /product="tRNA-Arg"
     gene            6086..6167
                     /locus_tag="NRO40_RS09865"
                     /old_locus_tag="NRO40_09865"
     gene            6304..6945
                     /locus_tag="NRO40_RS09870"
                     /old_locus_tag="NRO40_09870"
     CDS             6304..6945
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012618.5"
                     /locus_tag="NRO40_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09870"
                     /product="WD40 repeat domain-containing protein"
                     /protein_id="WP_058944642.1"
                     /transl_table=11
                     /translation="MIGRRGGRRDGSRGIRPRRASGLAAAPDGSWLASAGDDGTVRLWD
                     LRSGAPRAVLTCGGTVRSVAVSPDATWLASGGADGVVTVWDLATRTRRNQLTGGSGAVP
                     ALSVSPDGRRLFGGGHDGTLRLWDPRTGAYRGLRTGGGEPLHAVAASPDGRWIASAGQD
                     ATVRVWDRAGGRVLAAQRTEGALRSCSWHPDSRGLAVGGDRGLYVYRLLV"
     gene            7240..7938
                     /locus_tag="NRO40_RS09875"
                     /old_locus_tag="NRO40_09875"
     CDS             7240..7938
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NRO40_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NRO40_09875"
                     /product="NADH oxidase"
                     /protein_id="WP_157901928.1"
                     /transl_table=11
                     /translation="MVGSADVAERAGGRLRHLWSFREDVAVAAGARRDAVVVTWESGTV
                     AVEPAGPTVREVLRRMQLGPVLLGNAVVAGAAGEQDPHVYAYLLMRPVFARFPQLLRRT
                     VGFDDLRGALLSIGPLAEGAALCVPPLHAGAVLQLVVGVSVVFDRPSATVEMRSASHRV
                     VLHRYEALLVVARLAWPATPEAVAATLPIPAHVTTGILDYLVAAGVVGPVTPASPPPSR
                     SGSRPRGCGR"
     gene            complement(7877..8485)
                     /locus_tag="NRO40_RS09880"
                     /old_locus_tag="NRO40_09880"
     CDS             complement(7877..8485)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009995361.1"
                     /locus_tag="NRO40_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09880"
                     /product="DNA-binding response regulator"
                     /protein_id="WP_058944640.1"
                     /transl_table=11
                     /translation="MIRVLLAEDMHMVRGALEALLGLERDLTIVASVERGDEILPSARA
                     FAPDVAIIDIDLPGLDGISAAAQLHERLPSCRTLILTSLGRPGTLRRAMAAKVSGYLLK
                     DAPPQELAHAIRKVAAGQRVIDPELALAAWGGAESPLTARETEVLRLAAEGLDATDIGK
                     RLRLSTGTVRNYLTTVVTKLNARNRVDAIRIATEADWLV"
     gene            complement(8540..9817)
                     /locus_tag="NRO40_RS09885"
                     /old_locus_tag="NRO40_09885"
     CDS             complement(8540..9817)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006130565.1"
                     /locus_tag="NRO40_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09885"
                     /product="sensor histidine kinase"
                     /protein_id="WP_107115223.1"
                     /transl_table=11
                     /translation="MPSYEEHEPVAAGVRTSTSPAPRLARVIPLAVMTCYFVITVINLL
                     SRRPDTEVFVTGLITLSCVFGLQLFHSRRGADRAPAPARAATLTLQAVLTYLPLVWFGV
                     AWGAMAGFLGGSLLLLLPPRAAWPLYGLTGASLLVPGLALDMSVIDLVYMCQTTLLTGL
                     VVYGVSRLSALVDEVFAARAEIARMAVAHERLRLARDLHDLLGYSLSAIVLKSELLQRL
                     VRLRHERVEQEVEEVLAISRQALADVRRVSRGYRQMSLVSEVSSAQSVLEAAEVEATVV
                     VDPSVGSLGPRTGTVLATVLREAVTNLLRHSKATRCCITAVVDEGTARLTIVNDGVAAD
                     YHDPSPHGGDGLGNLRRRLSGVGGRLVVDREPPDTAGRDGWFRLVAEAPATPADEEPAQ
                     AGEAVEGGPEDGVEPAQEGPDRVTAA"
     gene            complement(10001..12487)
                     /locus_tag="NRO40_RS09890"
                     /old_locus_tag="NRO40_09890"
     CDS             complement(10001..12487)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358467.1"
                     /locus_tag="NRO40_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09890"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_079047433.1"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 2.9e-11,
                     bitscore: 41.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 2.9e-09,
                     bitscore: 35.3, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 9.7e-08, bitscore:
                     30.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.8e-60, bitscore: 203.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTRGNETVYVELKSHLRPAVVPGDAAYLVSHGGITALRGAPAE
                     VLVPLLDGTRTPAGLADAAAPALSREEVAEALRLLDRTGLLRYRGRPVPAPASPGAPPG
                     AGHGGARAAVPAPPYDRAAEAFFDLAGLDGARATARMARAAVRIVALPGTDPAPVRAAC
                     AASGLRVAEGDGDRGEAELTVVLCDDYLAPGLAEVDARHRRAGRPWLPARPAGPEPWVG
                     PVFRPDDGPCWACLAARLRGHRAAELAVMRALGPDRPLGRPEAALPAGRALAAQAMALE
                     AAKWVAGLRGPEAGRLRALDTRTLRVDAHPVPRLPQCPVCGDPGIVAARGLRPFTVRSR
                     PKAADGTGGGHRALTAEQMLERHGHLVGPVTGVVKELRRAPGAPAFTEAYVSGENLAVR
                     PAGPTGLRAGPRALSGGKGLTATEARVSALCEAVERYSGSRHGDEPVIRDTYRALGDEA
                     LHPNAVQLFHERQFRERDRWNAARSPFTAVPEPFDEDRPVDWTPLWSPATGARRLLPTS
                     MLYFSADPPHPREPVADSNGGAAGSSPEDALLQGVLELVERDAVALWWYNRTRQPAVDL
                     AAFDEPYVERLRAGYRALGREVWALDLTADLGIPVFAALSRRTPAARPAGPHPAGPEAG
                     PHPTGPEAGPHPAGPEAGPHPAGPGTGAGAGPAEEIVFGFGAHLDPRIALRRALTEMGQ
                     LLPAVAAVASGRDTGHDAAARWWRGATTANCPYLTPDPHAAPRGPGSWTHTHRADLRDD
                     LTAVTGLLVARGMELLVLDQTRPDTGIPVVKAVVPGLRHFWPRYAPGRLYDVPVALGRL
                     AEPTPYERLNPVPLFV"
     aSDomain        complement(12227..12451)
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NRO40_RS09890_NHLP_CD_RRE.1"
                     /evalue="4.60E-10"
                     /identifier="RREFam015.1"
                     /label="NRO40_RS09890"
                     /locus_tag="NRO40_RS09890"
                     /protein_end="87"
                     /protein_start="12"
                     /score="30.4"
                     /tool="antismash"
                     /translation="ELKSHLRPAVVPGDAAYLVSHGGITALRGAPAEVLVPLLDGTRTP
                     AGLADAAAPALSREEVAEALRLLDRTGLLR"
     aSDomain        complement(12227..12451)
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NRO40_RS09890_Cyanobactin_D_RRE.1"
                     /evalue="1.40E-11"
                     /identifier="RREFam007.1"
                     /label="NRO40_RS09890"
                     /locus_tag="NRO40_RS09890"
                     /protein_end="87"
                     /protein_start="12"
                     /score="35.3"
                     /tool="antismash"
                     /translation="ELKSHLRPAVVPGDAAYLVSHGGITALRGAPAEVLVPLLDGTRTP
                     AGLADAAAPALSREEVAEALRLLDRTGLLR"
     aSDomain        complement(12230..12454)
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NRO40_RS09890_Goadsporin_CD_RRE.1"
                     /evalue="1.40E-13"
                     /identifier="RREFam013.1"
                     /label="NRO40_RS09890"
                     /locus_tag="NRO40_RS09890"
                     /protein_end="86"
                     /protein_start="11"
                     /score="41.8"
                     /tool="antismash"
                     /translation="VELKSHLRPAVVPGDAAYLVSHGGITALRGAPAEVLVPLLDGTRT
                     PAGLADAAAPALSREEVAEALRLLDRTGLL"
     gene            complement(12484..12663)
                     /locus_tag="NRO40_RS09895"
                     /old_locus_tag="NRO40_09895"
     CDS             complement(12484..12663)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NRO40_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NRO40_09895"
                     /product="hypothetical protein"
                     /protein_id="WP_058944639.1"
                     /transl_table=11
                     /translation="MGDVIARATAAAGSTTESGRGPQPRRIVVDHLEGGPDDGVALFTF
                     CAVSSAVEGEPAGA"
     misc_feature    complement(12844..12856)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            13088..13531
                     /locus_tag="NRO40_RS09900"
                     /old_locus_tag="NRO40_09900"
     CDS             13088..13531
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF07366"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF019013.5"
                     /locus_tag="NRO40_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09900"
                     /product="ester cyclase"
                     /protein_id="WP_058944638.1"
                     /sec_met_domain="PF07366 (E-value: 1.1e-13, bitscore: 49.5,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDVQQGVGAELRRRREDTVIRNTLATVAEPPADGPGTAGGPAGG
                     VCRVVPFEEQPLVGDDAVRRHFDAMLAAFPDLAHEVLSIHHSADVVILEGRINGTQAAD
                     WQGIPNRGKRMELPVAVLSQFDGELLVDGTLYYDRAVAARQLV"
     gene            13556..14326
                     /locus_tag="NRO40_RS09905"
                     /old_locus_tag="NRO40_09905"
     CDS             13556..14326
                     /NRPS_PKS="Domain: Thioesterase (17-244). E-value: 4.6e-36.
                     Score: 117.3. Matches aSDomain:
                     nrpspksdomains_NRO40_RS09905_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009995366.1"
                     /locus_tag="NRO40_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09905"
                     /product="thioesterase II family protein"
                     /protein_id="WP_107115222.1"
                     /sec_met_domain="Thioesterase (E-value: 5e-32, bitscore:
                     110.3, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4e-09, bitscore:
                     35.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPHLRTPPSGPWSGLDLFCLPCAGGGASAYARWQERLDAFGARV
                     RVLPVQLPGREDRAGEPRFTDLDALVADLDERLDTAFARPHLLYGHSMGAFVAHALTLA
                     RQRRGAPLPRALVLSSHRAPHVRPDRILDPDADDEALATSLAELGGIPWELARRPRFRA
                     AYMPLVRDDLRLCSGWVEPADVEPLHVPLHLFTGVDDHLVPLPKMAAWRAHGARGSELR
                     TMPGGHFFVRAHEDELLRAVAALTTRYGSAVPAV"
     aSDomain        13607..14287
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NRO40_RS09905_Thioesterase.1"
                     /evalue="4.60E-36"
                     /label="NRO40_RS09905_Thioesterase.1"
                     /locus_tag="NRO40_RS09905"
                     /protein_end="244"
                     /protein_start="17"
                     /score="117.3"
                     /tool="antismash"
                     /translation="LFCLPCAGGGASAYARWQERLDAFGARVRVLPVQLPGREDRAGEP
                     RFTDLDALVADLDERLDTAFARPHLLYGHSMGAFVAHALTLARQRRGAPLPRALVLSSH
                     RAPHVRPDRILDPDADDEALATSLAELGGIPWELARRPRFRAAYMPLVRDDLRLCSGWV
                     EPADVEPLHVPLHLFTGVDDHLVPLPKMAAWRAHGARGSELRTMPGGHFFVRAHEDELL
                     RAVAA"
     CDS_motif       13808..13858
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NRO40_RS09905_0001"
                     /evalue="4.30E-05"
                     /label="NRPS-te1"
                     /locus_tag="NRO40_RS09905"
                     /protein_end="101"
                     /protein_start="84"
                     /score="16.1"
                     /tool="antismash"
                     /translation="PHLLYGHSMGAFVAHAL"
     gene            14364..16730
                     /locus_tag="NRO40_RS09910"
                     /old_locus_tag="NRO40_09910"
     CDS             14364..16730
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="NRO40_RS09910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09910"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_198549447.1"
                     /transl_table=11
                     /translation="MPATARRGGAAPPRAGGPVDLGFGELYGRERELGRVRDWLELGAP
                     ARQLTLTGPAGVGKSHLAHAAVGAHARAHGTALLWADLADAPDGGAVWALLGARSAREA
                     ADRVGGSELLLVLDDCDRLVADIALDVAGLLRACPLLRVLVTSRVALDIRAERILPVGP
                     LPTGAGSPAEAVFADRVRPYYRAGVDGGAGQLAVAEICRTLDGIPLAVEMAAEAVGTEG
                     PRALLERLARGECPGRSRPRDTHERHRSVAAALGWAAGTLDAGDVALLRDLSVCETHVD
                     LAAVRGVSGLDHAAAVAGVESLVHKSLLLSANGPDGEPEFRLTHMARCHHRAALARDGD
                     ALRRTLDRHAAHWCAFAGATAAALASGRHVDQVLQTVTARLPDLLKAVRHLTARGDHLA
                     ALRLLTALEGPLLRHRLAPSAADLVEEAAAAWAAGRGRDDHGNHGERGEHGDRGGAGNV
                     PGEPADAAGEVAGALAAVGWWAVACGDFRRAERVLDRAASLAAELPAVRARVAAVTGEL
                     LRRRGEAAAAAVLLDSAVRRLDALGEGRGAAPARRGQALLLAAHGDPDAERPLLRALDD
                     VADDVATRASLLTALARVRRVLGRNQEAYGSAREAARLLMGTGDPVQVAEALETMAVTS
                     VGGGGDQEQRHAVARVLAYAEAIRRRYGAGPGDGGTVGALTERLAGSVDAALLRRLRRD
                     AEQVSLHDALVAALFAPPPAPEPPRAVAGAAPHGLTPRQHEIALLVAEGLTNRQIARRL
                     GISEWTVTNHLRVVMQKLDCASRVHVVRAVQGSTA"
     gene            complement(17046..17546)
                     /locus_tag="NRO40_RS09915"
                     /old_locus_tag="NRO40_09915"
     CDS             complement(17046..17546)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004939538.1"
                     /locus_tag="NRO40_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09915"
                     /product="hypothetical protein"
                     /protein_id="WP_107115224.1"
                     /transl_table=11
                     /translation="MRQILSTTAVATAGLLLGGIATAAPATAVQSAAASQTVTARYDCG
                     AYGVTDLTIEASASGGAGSVRISTSGGLAPFDIPADSISATLRLERAAGGTVAFSGTAN
                     DAAAAGQPVTIGPLTGAVSAGDSLDSYVPAAGATDVSLSLNVLGIVNSCNAVGKQTPGP
                     IVF"
     misc_feature    17528..17541
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(17617..18819)
                     /locus_tag="NRO40_RS09920"
                     /old_locus_tag="NRO40_09920"
     CDS             complement(17617..18819)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661969.1"
                     /locus_tag="NRO40_RS09920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09920"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_058944635.1"
                     /sec_met_domain="DAO (E-value: 4.4e-07, bitscore: 28.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPPRAVVIGAGIGGLTAALALHRRGWRVTVLERAAGLAPVGAAL
                     TLAPNAQRALAALSLDEEVSRLAAWDGDGLLRDPRGRPLARTTSASVVTRFGGPLVVLR
                     RSDLVDLVVDRLPEGTVRTGEAAFLADAGAPGRPAKVSTTGEVYEADLVVCADGVNSAS
                     RRVLFPHHPGPAYGGWTVWRILAPTPQRFVPHETWGGGQVWGSLVRDPESVFIYACAVT
                     ERGGRSPDGEKAELRRRFGHWHHPVPALLDSIGEEDVLRHDVFHMAQPLERYQRGRSVL
                     LGDAAHAMVPTLGQGANMAIEDSVVLAHHAAPDADVPAALARYDQERRPRTTALIRRAE
                     RASRIMALRSPAALALRDGAIRAMAKVVPGLLLRGFDGVADWQPPVTPPGSRPRDTHAT
                     G"
     gene            complement(18899..19924)
                     /locus_tag="NRO40_RS09925"
                     /old_locus_tag="NRO40_09925"
     CDS             complement(18899..19924)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004939541.1"
                     /locus_tag="NRO40_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09925"
                     /product="3-oxoacyl-ACP synthase III family protein"
                     /protein_id="WP_058944651.1"
                     /sec_met_domain="fabH (E-value: 1.8e-25, bitscore: 88.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDVSLLEVASYMPGEPVGTEYFLPYQTQDAALAGHTMFKAPRFR
                     HQVSRDETPADMMEKAAHTLADRVGRDALRGVDVVITNTLLPEVPFTGPGAEVAHRLGI
                     RADWVLDAHNGGCASFVHLLRLARVLIGTGQARSALLLNVQNSAGPVMTQTEVRRLAEA
                     VIPGDGCGAAFVAASSESPVLGVKVAHHGEYTRDCGLTLDDGRKYWEPGTSQMHVGFTP
                     GRVKDIVERGNRLVPDVVLGLCAELGLGTADLDVLITNQPNRMFLEQWRRRLSIGPDRH
                     LDTFDRFGNLFGAAVPITLDHGVREGRIEDDSLLMLAGFAHAGDFAGAAAVHWRSGGAR
                     T"
     gene            complement(19951..20625)
                     /locus_tag="NRO40_RS09930"
                     /old_locus_tag="NRO40_09930"
     CDS             complement(19951..20625)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004939543.1"
                     /locus_tag="NRO40_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09930"
                     /product="hypothetical protein"
                     /protein_id="WP_058944634.1"
                     /transl_table=11
                     /translation="MTTSVTNPTPLPGYVAPEPIPAGVKDVPGLLRWETTPREEAMAVA
                     AQMTKDSFTYDEVYGRFVTVHQYIDAPPQAVYDYLTDVRNLNEYTYSTRDFAPTDVPGV
                     YQGRDVLLDDNTKIFMRIDGDPNALTVDMRCAWDQGEELWMNYLHRIVPAEIVLNRPGS
                     VVIWTNCRHPYYDENPHPELATTPDRPWVGDMWPLFYAGHQAEIDNLKKILEHRHGSGA
                     PA"
     gene            complement(20622..22409)
                     /locus_tag="NRO40_RS09935"
                     /old_locus_tag="NRO40_09935"
     CDS             complement(20622..22409)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014794.5"
                     /locus_tag="NRO40_RS09935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09935"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_079047432.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.5e-39, bitscore:
                     133.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-27, bitscore:
                     92.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSSPRVVDFVVDFLQRQEVSHVFGVGGANIEDLYDALHHAQAGP
                     LGVVAKHEFSAATMADGYHRASQRVPVIAATSGAGAMNLVPGIAELRASYVPALVLIGQ
                     PPAALDGRGSFQETSGLAGSIDAARMFAELAVYCVRVDDPESIVRELPRALAAATDPAA
                     PGPAVLLLPKDVQQAVIPSWDPPAAVAPAALPLSDAAERSRAAGLLRAAARRGGVAVIA
                     GEAVARADARPQLARLTAALGAAVAVVPDAKDVADPRDPGHLGIAGAIGTAEVQEALER
                     ASAVLLAGTRLPQMAGAGLHEHLKGVPVVCVDPREPFLGAHEELVRLTGPVAAELELLE
                     REVTTASGPAADRPTSGPAAEHPAPGRTARQPGPAPRPVRPAAAVPDPATSLDLRTAAL
                     TVAAHLPEGATVVADAGNTGAAAIHHVDVPPGGRFIAALGMGGMGHSFGAGVGAAFATG
                     RRTCVIAGDGAFFMHGMEVHTAVEHDLPVTFVVLNNNAHGMCATREQLFFSGDYSYNLF
                     RPARIGDGAAAMFPGLAADTVRTAGELGAALDRAHATSSPALVCVDVDPTEMPPFRPFR
                     QHVLLTGRGRPVREGAVPG"
     gene            22670..22921
                     /locus_tag="NRO40_RS09940"
                     /old_locus_tag="NRO40_09940"
     CDS             22670..22921
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (5-73). E-value: 2e-10.
                     Score: 32.9. Matches aSDomain:
                     nrpspksdomains_NRO40_RS09940_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009329945.1"
                     /locus_tag="NRO40_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_09940"
                     /product="acyl carrier protein"
                     /protein_id="WP_058945049.1"
                     /sec_met_domain="PP-binding (E-value: 4.1e-08, bitscore:
                     32.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITVATVCSLIEKKLGSKAAGLTLDENTAFDSVGLSSLQIADIVY
                     TIEDDAEIELDPSEAANVKTVGDLVTLVEATKSAGAAA"
     aSDomain        22685..22888
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NRO40_RS09940_PP-binding.1"
                     /evalue="2.00E-10"
                     /label="NRO40_RS09940_PP-binding.1"
                     /locus_tag="NRO40_RS09940"
                     /protein_end="73"
                     /protein_start="5"
                     /score="32.9"
                     /tool="antismash"
                     /translation="TVCSLIEKKLGSKAAGLTLDENTAFDSVGLSSLQIADIVYTIEDD
                     AEIELDPSEAANVKTVGDLVTLV"
ORIGIN
        1 gccgcggtac ctgcaacgcc tgacccggtg aagggatcaa ctacaagtcc tgcggtgggc
       61 agctgcaact gctgcaggag cagggaggca tagtcggacg cgaagcctgc tgggtagcga
      121 aaccatcgat cgaacggctc acttcggctg gtgccgtgcc ggcgtcctcg tcctgagctg
      181 ggctcaaaca ctggtgactc ttcctggagg accgcgccct ccggcatcgg cctgtggtta
      241 tcgctcatca acactcgccc attggaccac ggtgacagcc gtcaccacca cggtgatgcg
      301 ggatcggatt cagctggcgc cgaggatggt ggccagcacg acactgcgcg ctcgccaacc
      361 aggctctctg tagtactcca cgacgtcctg tcgcgcgccc aagaccggtg cgagcgcacg
      421 gtcaaacggc gcctggaggt cgcccaacca ctctagagtc cgtctgcgtt ggtcttgatc
      481 ctgccagtgg agttcggcgg cgaagaagtc tggcgcgaga tcttgcgcgt gtccgaggtt
      541 gttgttaccg accaacgcct ggaggaccgt gagtaggaag gccagcggtg tacttacata
      601 ttccctatct cgatcatccc aggagccagc aacaaggtgc tttgccagaa cacctgccag
      661 caaagcggct cgctcggggt cagagtggca ccaagcacgt gtatgcccag tgggtatctg
      721 cgcgaagtaa tcgaagtaca ggctagcgtc gtcttgatga gcgtcaacca gccggactag
      781 cgcctctagg cttccctcct gtccgagcgt gatcccttcc accagcctgc gggccttcgt
      841 tagtacaggc tcatcacggt cgttaagtac cacctgtacc atgtcccgca actcagacat
      901 ggtctgcgtc ctcaacgaag tctcttgccg cgtgcatgcg ttgacaaata gtcgccaatg
      961 caggaactcg ccgtcaggga gcagccgtac tccgcttgca ggggacgtcc cggtgaggta
     1021 ccaagcagca acgcgtccga ggctgtacac atccgccgct ggcgtggctt tacgggggtc
     1081 cacactcagt tcaggggcat cgtatcctgg cgtgcccatc ccctgaccgg tacgggtgag
     1141 aattcgggaa gcctcttcag gcggacgacg aaccatgccc caatccgcta ccacccaccg
     1201 gtatcttgca ccgctgtcgc cagagagagc gaggatattt tggggagaga tatcacgatg
     1261 aaccagcccg agttgatggg ccacatccag ggcttcaccg atagcaagga ggatggacgc
     1321 cagctcctct tcgtccggcc cttggcgaag gtctttgaga ttgccgaccg cgcgaggcat
     1381 cgtgtaccac gtgaagcctg gatcgtgatc caaaatcggc atgatgttag ggtgggctag
     1441 ccgcttctgg tcctgaatct cccgcttgat cctgtcctga gcatcctggc ggttgtaggc
     1501 gcgtttgagc gctacctctt cacccgtttt cttgtgcacg gcagggaata cctgggcata
     1561 gctcccgtgc cccagtgttc gagcgccgag acgataccgc tcctgtgcct tgatgctgct
     1621 gtccgacgca cctgccatgg gacccatccc cccctcagcc gggtcaacta ggcgcatatt
     1681 actggacctt ggcaggagtg actgttcatc tggcctcatg tccccaatcc gcggtcactg
     1741 gatgcgaggg tgaggtcgcc taggctagag ggcgtgctac ggctgaccaa ttaaggagtc
     1801 gcggcagcca ggcacaagaa ccgtccgtga ggcgcacgcc gaagctgtcg taccagccag
     1861 atgactggtg cacgagttga cgccagggtt cccaccgagc gctgcgtcgg cgtatgtgtt
     1921 cgtgctgatt ctgcggcttg tactgtcgag tggagggcgt tgggcttcgc atcctggccc
     1981 caacgagtct tcccatggga gctgaagagc cgtggacgac ccgtggacga ctcgtgcccc
     2041 accggtctca gccacgctgc ggcatgttgc cggccagccc ttccgcggac cgcggagtgg
     2101 cacacggctc cggaggggct gtgagaaccg tcgaatgttg ctggtcacag taacgttagc
     2161 cacccctgag atgttgccgg tccacgagtc gtccacgagt cgtccacgag tcgtccgtac
     2221 agcgaggcac acgcgcgcct gatcggtcga cgcgcccgcc atcgtggctg actgtcgtcg
     2281 gctgaggttc gtgccacaac cgtgccggat gcagcggcca gtcacggtcc accccggagc
     2341 cctgtggtcg acgtccggag cgctgctcct ccgtaaggag acgcgaagag aggcacccag
     2401 cccatggctt gggtgcctct cccattgagg tggaacggaa gtgggctctc agttgtcgcc
     2461 gcgcgccgac cgtcagaggc ggtggggctc gctcgcagtc aggcggtgac ctcggctgat
     2521 tgcgatgcgg agtacgtctc ggagggctcc ggtcagttcc tgtgccacgt ggcgcagggc
     2581 ttccgtgtcg gcgtcccctg cgccgagggt ttcctcggcc tcgaccagta ggtcggctgc
     2641 cgtgcccagc tgaacagctt cgatgttgtc ggccaggcgg gacatgtagc tgtccttgtc
     2701 gtcggtgctc aggtagcagg gcttgccgtc cgggccggac cacgggagga ggcgtagctc
     2761 gttcgctgtg gtcatgctcg cgtctgcctc tcgtcggtca tggcgtgggt ggtgaagacg
     2821 gcatcgacgc ggtcccccgg gaacaccagg aacgcggctt cgacgaccct cccggtggag
     2881 tcggtggcca cacgcgtgat cgcgaggacc ggcgcggtgg agttggtccg gagggtcgat
     2941 gcttcgtccg gtgtcggtgg gcgggcacag gccgtctccc ggacaatggc cggcggcagg
     3001 ctgaggacag cgaatctcgt gaccgcctca cggcacagtg gctcgtcgcc gagtacaccg
     3061 tccggtgcca ggtcccgggg gatgtaaatg cgtgccaggc catgcggtgc gtccccctcg
     3121 tggctgacgc agaagaactc tgcaaggggg cttcccgccg gcaccttcag tagttccgcc
     3181 aagtgcccgt gcgcccggac cgtggcgcag cgcactgtga tgtgcagggc cgcttcagcg
     3241 gccgtccacg ggtccagcat cccccatccg ccgacgtaca tgatcttgcg gagtggacgg
     3301 cggacgaagt tgcccttgcc gtggatcttc tcgacgagtc cttcgccttg gaggaccgcg
     3361 agagcgcggc gcagggtcac cgtgctcact ctgtacccgc tcgccaggac ggcctcggac
     3421 ggtaggcgtt caccgggctt gatgcggctg gtcgcgatct ggttccggag gtcgtcggcg
     3481 atctcgtgat ggcgcgaggc cacgggcccg gtcaccgcct tcccatcatc ctgacggcga
     3541 cgagccgggt acgggcgtgc atcgtcagca gctcgccgga ctcgaagatc agttgcttgg
     3601 caccgtgggg cagttggaag aggtcctgca ctcggcagaa cagtcccccg agttctatga
     3661 catcgccgcg ccggaccgtg gccgccgtca cctcgatgct ggcggccggc atcctcctgg
     3721 gcgtgcggtc gatcactgtt ccactcccgc gcacgcgaac cggtcgggcg tcgagtggca
     3781 caggcagtcg cacctctcgt agaccacggg gatgtcgacc ggcggcgaca gcggcgaggc
     3841 ctccgcgcac gtggggtgcg tgccgatccg gcatgcggtg gatcggtagg ggatggcggc
     3901 gacggtggtg tgaggctgtc ggcgaggctt catccatggg ctcccagaag ggtcgagcag
     3961 gcgtcagccg gcagacgggg ggcgacgatc acggaacggg tccgtacgcg ctcctcccag
     4021 gccagcaggt acggacgtac gagcgcgacg tcctcaccgg cgagtgggtg ccggtggccc
     4081 tggtcgccgg cccggcctgg aggggttgtc gactcgccgg cggactccgg gggcacggtc
     4141 gccgtcgacg gccggtaggg cgctaaggat cggcggtgcc tgcccttggg gaagtaccgc
     4201 gctctggtga gcgaggcggc acggcggata cggttgaaca cgctgctcag ctcctatcgc
     4261 tgatggctcg gtcccccgac atcgcccgtc gtggggaccg ctttgcgtac gaccgcccag
     4321 agggtgcggt cgttcaggct ggtggccaga agcccgaacc ggtcggcctc ggccaccact
     4381 tggaggaccc cccgccataa gtccgcggag agcgatcccg gcacttccgc ttcgaccgtc
     4441 gtgtgccggt cgtgctcctg cacacgtgcg ggaagcccga gggcggacaa ccgggcggcg
     4501 atgcccgccg cgctaactcc cgaagcgggc acagggcagc ctccgtcacc ggcaatcact
     4561 ttcagtgaag ctagttaact aggttagagc tagtggacta gattttccat atgcctgagc
     4621 agccgcccta tctccgcgtc gctgacgagc ttcggcggcg gatcgcggag cacgtatggg
     4681 agccgggaga tcgtctgccg tcccgcgccc agatcggtca ggagtgcggg gtcggtgaga
     4741 acgtggtccg gcgggctcag gagctgctga tctcccaggg cgtgctggag ggccgcgccg
     4801 gttcgggcac gtacgtcgcc gagccccgac agcgtgtgcg catggtgcgg tcggccgcgc
     4861 gtgagcggcc cgacgggtcg ccgttccggg tggacatgaa ggccttgggc aagcgagggg
     4921 actgggagag ccggaccgac gccaaggtgc cggcgcccgc ggacatcgcg gtccggctcg
     4981 gcatcgccga gggagacccg tgcgtccgca cggtggtacg agttcctggc cgacggcagg
     5041 ccgatgcaac cggagccgag gcaggcgacc gccgaggagg cgtcacttct gggcatccag
     5101 aagtccgcgc tcgtcaccca catccgccgg acctactaca gcgacgaggg gcggccggtg
     5161 gagacggcgg acatcgtggt gccggccgcc cactgcgaga tcgtctacga gatcccgatc
     5221 attcgtccct agtgctgtga ccgcataggt ggacgggtcg gcggtcgtag cggttggatg
     5281 tcctacttga ccagccggaa ggcggggtgc ccggcccagg cccgcaggaa ctccgccgtt
     5341 cccagcgcca tccagtcgtc gtccgcgatc cccaacaccc ccggaaggcc ggcgacgacc
     5401 ggcgcctgtc cgtccagcag ctcggctttg gccacgcccc cgatgacgtc catgacagcg
     5461 gcggtcagca gggccgtggc cacgtggtcg atctcgcgat tgcagccggc gctgacattg
     5521 acggcatggg tcggcctgaa gccgaggacg gcctctacct cgggctcgtc cgcgtgctca
     5581 gcctcgaaaa tgctctcatc gccgacaccc ggccccatca agtagaccag gaacggccga
     5641 cgccaatcct cgcgctgcgg attgaatccc accagggccc tcagcccctc gtccgcggag
     5701 gtgtcgtcga ggagtggaag cgggaacggc tttcgccagt cctccccccg cctgtcctcg
     5761 acgcccagtc gctctgcggg cacgttgacg tcgaagcacc cgggccgctc ctcgtcaaag
     5821 tgcgaggaga cccccaccat caacgcgcga aactcccgca gcgcaaccgg ggagagcggc
     5881 tccgccaact cgatcaccaa cgtcggtcca gacatgctgg gagcctacgt tgatcggctc
     5941 cccgacctcc tcagattgtt cccacaccga gtacagccgg tccgagcacc gacgccacca
     6001 acccagcgaa cctatgcggt cagaacacta gcccgtcgaa tgcgtgtcga agtcgggccg
     6061 acgggatacc gagagcgaga ggcgagccag gtcagcgggg gtatggcgtt ggagtcgccg
     6121 agtgccttct aagcacttgg ccgcaggttc gagtcctgcc gggggcgctt tggacacgac
     6181 cctcccgcgg gagggtcttt ttgctggtcg gggtcggttt tcgaccaagg gcccggggcg
     6241 gcttccgggg cggtggggtg ggtggtttcg gggggtgggt gccggtggtg gggtcggtgc
     6301 ggcatgatcg gccgccgtgg gggccggcgg gacggcagcc ggggcatccg cccccggcgg
     6361 gcttccggtc tggcggccgc accggacggc agctggctgg ccagcgcggg ggacgacggc
     6421 acggtacggc tctgggacct ccggtcgggg gcgccgcggg ccgtgctgac ctgcggcggc
     6481 acggtgcgtt ccgtggcggt ctccccggac gcgacctggc tggcgagcgg cggcgccgac
     6541 ggcgtggtca ccgtctggga cctggccacc cgtacccgga ggaaccagct gaccggcggg
     6601 agcggcgcgg tgccggcact gtcggtctca ccggacggac gccggctgtt cggaggcggc
     6661 cacgacggga ccctgcgcct gtgggacccg cggaccggtg cctaccgggg cctgcgcacc
     6721 ggcggcgggg aaccgctgca cgcggtggcc gcctccccgg acggccgctg gatcgcctcg
     6781 gcgggccagg acgccacggt acgggtgtgg gaccgcgcgg gcggacgggt gctggccgcc
     6841 cagcggaccg agggggcgct gcggtcctgt agttggcacc ccgacagcag gggtctcgcc
     6901 gtcgggggcg accggggtct ctacgtctac cgcctgctgg tgtgaggccg gcctccgccc
     6961 cgccccggag acgggcgggc gccgggcacc gggcaccgga cgggcgccgc ggacggcacc
     7021 cgcgccccga gagcacgacc ccccgcttga ccgacgcccg cccggcggtg gtcccgaccg
     7081 gacgacgccg cggcgctgcc gggtccgggc gtgtccggtg ggtcggaccg tggggcgtcg
     7141 gaccgtgagc gattcatgga tggtgcatga actcgtggct gtcgcgggtg cgggcggcgc
     7201 tctcatgctg gaggcccagg ggtacggcga ggagtgcgga tggtgggctc ggctgatgtg
     7261 gcggagcggg ccggtgggcg gttgcggcac ctctggtcgt tccgggagga cgtggcggtg
     7321 gcggccgggg cgcggcgcga cgcggtggtc gtcacgtggg agtccgggac cgtggcggtc
     7381 gagccggccg ggccgaccgt gcgggaggtg ctgcggcgga tgcagctggg gcccgtgctg
     7441 ctgggcaacg ccgtcgtcgc cggggccgcc ggggagcagg acccgcacgt gtacgcgtac
     7501 ctgttgatgc gtccggtctt cgcgcgcttc ccgcaactgc tgcgccgcac cgtcggcttc
     7561 gacgacctgc gcggggcgct gctgtcgatc gggcccctcg cggagggcgc ggcgctgtgc
     7621 gtgccgccgc tgcacgcggg ggccgtcctg cagctggtgg tcggggtgtc ggtggtgttc
     7681 gaccgcccgt cggccacggt ggagatgcgg tcggcctcgc accgggtggt cctccaccgg
     7741 tacgaggccc tgctcgtggt cgcccgcctg gcgtggccgg ccacgcccga ggccgtggcc
     7801 gccacgctgc cgatacccgc gcacgtcacg acgggcatcc tcgactacct ggtggccgcc
     7861 ggggtcgtcg ggccggtcac accagccagt ccgcctccgt cgcgatccgg atcgcgtcca
     7921 cgcggttgcg ggcgttgagc ttcgtgacga cggtggtgag gtagttgcgg acggtgcccg
     7981 tggacagccg cagccgcttg ccgatgtccg tcgcgtccag gccctccgcc gccagccgca
     8041 gcacctcggt ctcgcgggcg gtcagcgggc tctccgcgcc gccccacgcg gccagcgcca
     8101 gttcggggtc gatcacccgc tggccggccg ccaccttgcg gatggcgtgc gccagttcct
     8161 gcggcggcgc gtccttgagc aggtaccccg acaccttggc ggccatcgcg cggcgcaggg
     8221 tgcctgggcg gccgaggctg gtcaggatga gcgtccggca cgacggcagc cgctcgtgga
     8281 gctgcgcggc ggcgctgatc ccgtcgaggc ccggcaggtc gatgtcgatg atggcgacgt
     8341 ccggcgcgaa cgcgcgggcg gacggcagga tctcgtcacc gcgttccacg ctcgccacga
     8401 tcgtcaggtc ccgttcgaga ccgaggaggg cctccaacgc cccccgcacc atgtgcatgt
     8461 cctcggccag caggacacgg atcatcggag ctcccccttg ctctccagac gtggacggac
     8521 actttagcaa ccggcccgat caagccgccg tgacgcgatc cgggccctcc tgcgcaggct
     8581 ccacgccgtc ttccgggccc ccctccacgg cctccccggc ctgcgcgggc tcctcgtcgg
     8641 cgggcgtggc gggcgcctcc gcgacgagac ggaaccagcc gtcccgcccc gccgtgtccg
     8701 gcggttcacg gtccacgacg agccggccgc cgacgccgga cagccggcgc cggaggttgc
     8761 ccaggccgtc cccgccgtgc ggggacgggt cgtggtagtc cgccgccacc ccgtcgttga
     8821 cgatggtgag gcgggccgtc ccctcgtcga cgacggccgt gatgcagcac cgcgtcgcct
     8881 tgctgtggcg cagcaggttc gtcaccgcct cccgcaggac cgtcgcgagg accgtgcccg
     8941 tccgcggccc gagggacccg accgacgggt cgaccaccac cgtcgcctcc acctccgccg
     9001 cctccagcac ggactgcgct gacgacacct cggagacgag cgacatctgc cggtagccgc
     9061 gcgagacgcg gcgcacgtcg gcgagggcct gccgggatat cgcgaggacc tcctccacct
     9121 cctgttcgac ccgctcgtgg cgcagccgca ccagccgctg gagcagctcg ctcttgagga
     9181 cgatcgcgga caggctgtaa ccgagcaggt cgtgcaggtc gcgggcgagc cgcagccgtt
     9241 cgtgcgccac ggccatgcgg gcgatctcgg cgcgcgccgc gaacacctcg tcgacgaggg
     9301 cggacagccg cgagacgccg tacaccacca gaccggtcag gagcgtggtc tggcacatgt
     9361 agacgaggtc gatgacggac atgtcgaggg ccaggcccgg cacgagcagg ctcgcgcccg
     9421 tcagcccgta cagcggccag gcggcccgcg gcgggagcag caggagcagg gagccgccga
     9481 ggaaaccggc catcgcgccc caggccacgc cgaaccagac gagcggcagg taggtgagga
     9541 cggcctggag ggtgagcgtg gccgccctgg ccggggccgg agcgcggtcg gcgccgcggc
     9601 gcgagtggaa cagctgcagg ccgaacacgc acgagagcgt gatcagaccg gtcacgaaca
     9661 cctcggtgtc cggtcggcgg ctcaggaggt tgatgacggt gatcacgaag tagcaggtca
     9721 tcaccgcgag cgggatgacg cgggccagcc ggggcgccgg gctggtgctc gtcctcaccc
     9781 cggcagcgac gggctcgtgc tcctcgtagc tgggcattcg ggtgctcctc gtccgcgcgt
     9841 ggcagagtcc ggggcgccct gctccacggg caccccgcga ctggaggggc cagtgtgacc
     9901 ccagacactc tttcgggtga ctctacgtcg agcggccgtc aggtccgcac ttttcagttg
     9961 aacccctcga acacccggtc gcggcggtca ccgggggcgc tcagacgaac agcgggaccg
    10021 ggttgagccg ttcgtacggg gtcggttcgg ccaggcggcc caaggccacg gggacgtcgt
    10081 agagccggcc gggggcgtac cgcggccaga agtggcgcag cccggggacg acggccttca
    10141 ccacggggat gccggtgtcc ggccgggtct ggtccagcac cagcagctcc atcccgcggg
    10201 ccaccagcag gccggtgacg gcggtcaggt cgtcgcgcag gtcggcgcgg tgggtgtgcg
    10261 tccaggagcc ggggccgcgc ggcgcggcgt gcggatcggg cgtcaggtac gggcagttcg
    10321 cggtggtggc gccgcgccac cagcgggccg cggcgtcgtg gccggtgtcc cggccggacg
    10381 ccaccgccgc cacggcgggg agcagttggc ccatctcggt cagcgcgcgg cgcagcgcga
    10441 tccgcgggtc gaggtgggcg ccgaagccga agacgatctc ctcggccggg cccgcgcccg
    10501 caccggtgcc ggggccggcc ggatgcgggc cggcctccgg gccggccgga tgcgggccgg
    10561 cctccgggcc ggtcgggtgc gggccggcct ccgggccggc cgggtgcggg ccggccgggc
    10621 gtgcggcggg cgtgcggcgg gagagcgccg cgaacaccgg gatcccgagg tccgccgtca
    10681 ggtccagggc ccagacctcc cggcccagcg cgcggtaccc ggcacgcagc cgctcgacgt
    10741 acggctcgtc gaacgcggcg aggtccacgg ccggttggcg ggtgcggttg taccaccaca
    10801 gggccaccgc gtcccgctcc accagctcca gcacgccttg gagcagggcg tcctccggac
    10861 tgctgcccgc ggcgccgccg ttggagtcgg cgaccggctc gcgcgggtgg ggcgggtcgg
    10921 cggagaagta cagcatgctc gtgggcagca gccggcgcgc gcccgtggcc ggcgaccaca
    10981 ggggcgtcca gtcgacgggc cggtcctcgt cgaacggctc gggtacggcg gtgaacggtg
    11041 accgcgcggc gttccaccgg tcccgctcgc ggaactgccg ctcgtggaag agctggacgg
    11101 cgttggggtg gagggcctcg tcgccgaggg cccggtaggt gtcgcggatg acgggttcgt
    11161 cgccgtggcg ggagccgctg taccgttcca cggcctcgca cagggcgctc acccgcgcct
    11221 cggtggccgt caggcccttg ccgccgctga gcgcgcgcgg cccggcccgc agcccggtgg
    11281 gtccggcggg ccgcacggcg aggttctcgc cggagacgta cgcctcggtg aaggcgggcg
    11341 cgccgggggc ccgccggagc tccttgacca caccggtgac cggcccgacg aggtggccgt
    11401 ggcgctccag catctgctcg gcggtgagcg cgcggtggcc gccgcccgtg ccgtcggcgg
    11461 ccttgggccg gctgcggacg gtgaaggggc gcaggccccg cgcggcgacg atccccgggt
    11521 ccccgcagac cgggcactgc ggcagccgcg gcaccgggtg ggcgtcgacg cgcagggtcc
    11581 gcgtgtccag ggcgcgcagc cgcccggcct cggggccgcg cagcccggcg acccacttgg
    11641 ccgcctccag ggccatggcc tgcgccgcca gggcgcggcc ggccgggagg gcggcctccg
    11701 gccggcccag cgggcggtcc gggcccaggg cgcgcatcac ggccagttcg gcggcgcggt
    11761 ggccccgcag ccgcgccgcg agacatgccc agcaaggccc gtcgtccggg cggaagacgg
    11821 gcccgaccca cggctcgggt ccggccggtc gggccggcag ccacggtcgg ccggcccgcc
    11881 ggtgccgggc gtccacctcg gcgaggccgg gcgcgaggta gtcgtcgcac aggacgacgg
    11941 tcagctccgc ctccccccgg tccccgtccc cttccgccac gcgcagcccg gaggcggcgc
    12001 aggcggcccg taccggggcg gggtccgtgc ccggcagggc gacgatccgc acggccgccc
    12061 gcgccatccg cgcggtggcg cgggcaccgt ccaggccggc gaggtcgaag aacgcctcgg
    12121 cggcccggtc gtacggcggt gcgggcacgg cggcccgcgc gccgccgtgc ccggcgcccg
    12181 gtggcgcccc gggcgatgcc ggcgcgggca cgggacgtcc gcggtaccgc agcagccccg
    12241 tccggtcgag cagccgcagc gcctcggcga cctcctcccg gctcagcgca ggcgcggcgg
    12301 cgtccgccag gccggccggg gtgcgggtcc cgtccagcaa cgggaccagg acctcggcgg
    12361 gggccccgcg cagcgccgtg atccccccgt gcgagacgag gtaggcggcg tcccccggga
    12421 ccacggcggg ccgcaggtgg ctcttcagtt cgacgtagac ggtctcgttc ccccgggtga
    12481 ccgtcatgcg ccggcgggct cgccctcgac cgcggacgac acggcgcaga aggtgaacag
    12541 cgcgaccccg tcgtccgggc cgccctccag gtggtccacg acgatgcggc gcggctgcgg
    12601 gccccggccc gactcggtgg tggacccggc ggccgcggtg gcccgggcga tgacgtcccc
    12661 catgtgcgta ctcctcggtt cctcgggtgg tccccgactc ttcggctggt ccggctcttc
    12721 ggctgggtcg gaccgctcgg ctggtccggc tcttcggacg gtccggccgc gacccgcacc
    12781 gcgggtgtcc gcgtccgccg tgcggtcacc cggatcctgc taccggggcg gcgggcgcag
    12841 acagtgacgg cgtcacccgt ggggcgtgac gatctcccgt cgcccggccg cccccgccca
    12901 ctcccccaca ggcgccgcct ccgtgacccc ggccgggtat gacggcttca cgtccggtcc
    12961 gagaggaaca catcccgcgc accgggagga ggccactgtc ccgccgcccg gggccgttgc
    13021 aggcttcgac gggtacgggc cgggtcgccg cacgccccgg ccggcaacgg ggagaagagg
    13081 tacgcggatg cacgacgtgc agcagggggt cggcgcggag ctgcggaggc ggcgcgagga
    13141 cacggtcatc aggaacaccc tcgccacggt ggcggagccg cccgccgacg ggccgggcac
    13201 ggcgggcggg ccggccggcg gcgtgtgccg cgtcgtgccg ttcgaggagc agccgctggt
    13261 cggcgacgac gcggtccgcc gccacttcga cgcgatgctc gccgccttcc cggacctggc
    13321 gcacgaggtg ctgtcgatcc accactcggc cgacgtggtg atcctggagg gccggatcaa
    13381 cggcacgcag gccgcggact ggcagggcat accgaaccgg ggcaagcgga tggagctgcc
    13441 cgtggcggtg ctctcccagt tcgacgggga gctgctggtc gacgggacgc tgtactacga
    13501 ccgcgcggtc gccgcccggc agctggtctg aggcgcggcg gggagcacgt acgccatgac
    13561 gccccacctg aggaccccgc cgtccgggcc gtggtccggg ctggacctgt tctgcctgcc
    13621 ctgcgccggg ggcggggcct ccgcctacgc ccgctggcag gagcggctcg acgccttcgg
    13681 cgcccgcgtg cgggtcctgc cggtccagct gccgggccgg gaggaccgcg cgggcgagcc
    13741 gcgcttcacc gacctcgacg cgctcgtcgc ggacctggac gagcggctcg acacggcgtt
    13801 cgcccggccg cacctgctgt acgggcacag catgggcgcg ttcgtcgcgc acgccctgac
    13861 gctcgcgcgg cagcggcggg gcgcgccgct gccgcgggcg ctggtgctga gctcgcaccg
    13921 ggccccgcac gtacgccccg accggatcct cgacccggac gccgacgacg aggcgctcgc
    13981 cacgagcctg gccgaactgg gcggcatccc ctgggagctg gcccgccggc cccgcttccg
    14041 ggcggcgtac atgccgctgg tccgcgacga cctgcggctg tgctcgggct gggtggagcc
    14101 ggccgacgtc gaaccgctcc acgtgccgct gcacctgttc accggggtgg acgaccacct
    14161 cgtgccgctg ccgaagatgg cggcgtggcg ggcgcacggg gcgcgcggca gcgagctgcg
    14221 gaccatgccc ggcgggcact tcttcgtccg tgcccacgag gacgagctgc tgcgcgcggt
    14281 cgccgcgctc accacccggt acggctccgc cgtgccggcg gtctgacggg ggccggacgg
    14341 tgaggagcga ggaggtggcg cccgtgccgg ccaccgcgcg gcgcggcggc gcggccccgc
    14401 cccgcgccgg cggccccgtc gacctggggt tcggcgagct gtacgggcgc gaacgcgaac
    14461 tgggccgggt ccgcgactgg ctggagctgg gggcgccggc gcgccagctc accctgaccg
    14521 gccccgcggg cgtcggcaag agccacctgg cgcacgcggc ggtcggcgcg cacgcccgtg
    14581 cccacggcac cgcgctgctg tgggcggacc tcgccgacgc gccggacggc ggggccgtgt
    14641 gggcgctgct cggcgcccgc tccgcacggg aggctgccga ccgggtcggc ggctcagagc
    14701 tgctgctggt gctggacgac tgcgaccggc tggtcgccga catcgccctg gacgtggcgg
    14761 ggctgctgcg ggcctgcccg ctgctgcggg tcctggtgac cagccgggtc gcgctggaca
    14821 tccgcgcgga gcggatcctg ccggtcgggc cgctgcccac cggggccggc tcgccggccg
    14881 aggcggtctt cgcggaccgg gtgcgcccgt actaccgggc cggtgtcgac ggcggggcgg
    14941 ggcagctcgc ggtggcggag atctgccgga cgctggacgg gattccgctc gccgtcgaga
    15001 tggccgccga ggcggtcggc accgaggggc cgcgcgccct gctggagcgg ctggcgcgcg
    15061 gcgagtgccc cggccggagc cggccgcgcg acacccacga gcggcaccgc agcgtcgccg
    15121 ccgcactggg ctgggcggcc gggacgctgg acgcgggcga cgtggcgctg ctgcgggacc
    15181 tgtccgtgtg cgagacgcac gtcgacctgg ccgcggtgcg cggtgtgagc gggctcgacc
    15241 acgcggcggc ggtcgccggg gtggagtcgc tggtccacaa gagcctgctg ctgagcgcga
    15301 acgggccgga cggcgaaccg gagttccggc tgacgcacat ggcgcgctgc caccaccggg
    15361 cggcgctcgc ccgcgacggc gacgcgctgc gccgcaccct cgaccggcac gccgcgcact
    15421 ggtgcgcctt cgccggggcg accgccgcgg cgctcgcctc ggggcggcac gtcgaccagg
    15481 tcctccagac ggtcacggcc cgcctgccgg acctcctcaa agccgtacgg cacctgacgg
    15541 cgcgcggtga ccacctcgcc gcgctgcggc tgctgaccgc gttggagggg cccctgctcc
    15601 ggcaccggct ggccccgtcg gcggcggacc tcgtcgagga ggccgcggcg gcgtgggcgg
    15661 ccgggcgggg acgggacgac cacgggaacc acggtgagcg cggggagcac ggcgaccgcg
    15721 ggggtgccgg gaacgtgccc ggggagccgg cggacgcggc cggggaggtc gccggggcgc
    15781 tggccgcggt gggctggtgg gccgtggcgt gcggggactt ccggcgcgcc gagcgggtgt
    15841 tggaccgggc ggcgtccctc gcggcggagc tgcccgcggt gcgggcgcgc gtcgccgcgg
    15901 tcaccgggga gctgctgcgg cgccggggcg aggcggcggc cgcggccgtg ctgctcgact
    15961 cggcggtacg gcgcctcgac gcgctcgggg aaggccgcgg cgccgcgccg gcccgccgcg
    16021 gccaggcgct gctgctggcc gcgcacggcg acccggacgc ggaacgaccg ctgctgcgcg
    16081 cgctggacga cgtggcggac gacgtcgcga cgcgggcgtc cctgctgacg gcgctggccc
    16141 gggtgcggcg ggtgctcggg cggaaccagg aggcgtacgg cagcgcgcgg gaggccgcgc
    16201 ggctgctcat ggggaccggg gacccggtgc aggtcgccga ggcgctggag acgatggcgg
    16261 tcacgtccgt cggcgggggc ggggaccagg agcagcggca cgcggtggcc cgggtgctgg
    16321 cgtacgcgga ggccatccgc aggcggtacg gcgccggccc gggcgacggg ggcacggtgg
    16381 gcgcgctgac cgagcggctc gccggcagcg tggacgccgc gctgctgcgg cggctgcgcc
    16441 gggacgccga gcaggtgtcg ctgcacgacg cgctggtcgc cgcgctgttc gcgccgccgc
    16501 ccgcgccgga gccgccgcgc gcggtggcgg gggcggcgcc ccacgggctg acgccgcgcc
    16561 agcacgagat cgccctgctg gtcgccgagg ggctcacgaa ccggcagatc gcccgtcggc
    16621 tcggcatatc ggagtggacg gtgaccaacc acctgcgggt ggtgatgcag aaactcgact
    16681 gcgcctcccg ggtgcacgtc gtccgcgcgg tccaggggag cacggcctga aggggacagg
    16741 tcgtgcccgc cgaagcccgc cggagcctgc cgagcccgcc gaagcctgcc caacagggcg
    16801 tgcgggccga accctgccgg ccagggcgtg ccgggtccgc gcgtgcggac cggagcctgc
    16861 cgaacagggc gtgcggaccg gagcctgccg aacagggcgt gcgggccgga gcgtcgcccg
    16921 ccagggcgtg ccgggtccgc gtgtgcggac cggccgggcc caccgcacca ggggcccggc
    16981 cggccgttcc cgggggcccg gccgtccggg gacggccggg ccggtgaagg gggttcggcg
    17041 ccggatcaga agacgatcgg accgggcgtc tgcttgccga ccgcgttgca cgagttgacg
    17101 atgccgagga cgttcaggct cagcgacacg tcggtggccc cggcggccgg gacgtacgag
    17161 tcgaggctgt cacccgccga cacggcgccc gtcaggggac cgatggtgac cggctggccg
    17221 gccgccgcag cgtcgttggc ggtgccgctg aacgcgacgg tgccaccggc ggcacgctcc
    17281 aggcgcagcg tggcgctgat ggagtcggcc gggatgtcga acggggcgag tccgccgctg
    17341 gtggagatgc gcaccgagcc ggcaccgccc gaggcggacg cctcgatggt gaggtcggtg
    17401 acgccgtacg cgccgcagtc gtagcgggcc gtcaccgtct gggaggcggc cgcggactgg
    17461 acggcggtgg ccggggcggc cgtggcgatg ccgccgagga ggagcccggc ggtggcgacg
    17521 gcggtggtgg acaatatctg acgcatcatc aaaacctttc cactgactac gggtggtgtg
    17581 cgtggaaacg tccgggcggc gcgtgcgccg ccgcggttac ccggtcgcgt gggtgtcacg
    17641 cggccgggag cctggtgggg tgaccggcgg ctgccagtcg gcgaccccgt cgaagccgcg
    17701 cagcagcagt ccggggacga ccttcgccat cgcccggatc gcgccgtcgc gcagggcgag
    17761 cgcggccggg gagcggagcg ccatgatccg ggacgcgcgt tcggcgcggc ggatgagggc
    17821 cgtggtgcgg ggccggcgct cctggtcgta ccgggcgagg gcggccggca cgtcggcgtc
    17881 gggcgccgcg tggtgggcga gcacgacgct gtcctcgatc gccatgttgg cgccctgccc
    17941 gagggtgggc accatggcgt gcgcggcgtc gccgaggagg acggaccggc cgcgctggta
    18001 gcgctccagc ggctgcgcca tgtggaacac gtcgtggcgc aggacgtcct cctccccgat
    18061 cgagtcgagc agggcgggca ccgggtggtg ccagtgcccg aagcggcggc gcagctcggc
    18121 cttctccccg tccggtgagc ggcccccgcg ctcggtgacg gcgcaggcgt agatgaagac
    18181 gctctccggg tcgcggacga ggctgcccca cacctgcccg ccgccccagg tctcgtgggg
    18241 gacgaaccgc tgcggggtgg gcgccaggat ccgccacacc gtccagccgc cgtacgccgg
    18301 tccggggtgg tgggggaaga ggacgcggcg gctcgcggag ttgacgccgt cggcgcacac
    18361 gacgaggtcc gcctcgtaca cctcgcccgt cgtcgacacc ttcgccggcc gtccgggcgc
    18421 gcccgcgtcg gcgaggaagg cggcctcgcc ggtgcggacg gtgccctccg ggagccggtc
    18481 gacgacgagg tcgacgaggt cgctgcggcg cagcacgacc agcggtccgc cgaagcgggt
    18541 gacgacggac gcgctggtcg tcctggcgag cggccggccg cgggggtccc gcagcaggcc
    18601 gtcgccgtcc caggcggcga gccggctgac ctcctcgtcg agggagaggg cggccagcgc
    18661 gcgctgggcg ttgggggcca gggtgagcgc cgcgccgacc ggggcgaggc cggcggcgcg
    18721 ctccagcacc gtcacccgcc agccgcgccg gtgcagcgcc agcgctgccg tgagaccgcc
    18781 gattcccgcg ccgatgacga ctgctcgtgg aggggacatg aactctcctt gggggtgtcc
    18841 ggtcaggtgg gtcgcggtgc ccgccggggg gtgtcctgcc tgatcggcac gacgccccct
    18901 acgtccgggc gcccccggac cgccagtgca ccgccgcggc gcccgcgaag tcccccgcgt
    18961 gggcgaagcc ggccagcatg agcaggctgt cgtcctcgat ccttccttcg cgtacgccgt
    19021 ggtccagtgt gatgggcacg gcggcgccga agaggttgcc gaaccggtcg aaggtgtcca
    19081 ggtgccggtc ggggccgatg gacaggcgcc gccgccactg ctccaggaac atccggttcg
    19141 gctggttggt gatgaggacg tccaggtcgg cggtgcccag gccgagttcc gcgcacaggc
    19201 cgaggacgac gtcgggcacg aggcggttgc cgcgctcgac gatgtccttg acgcggccgg
    19261 gggtgaaccc gacgtgcatc tggctggtgc ccggctccca gtacttgcgg ccgtcgtcga
    19321 gggtcaggcc gcagtcccgg gtgtactcgc cgtggtgagc gaccttgacg ccgaggacgg
    19381 gcgactccga ggacgccgcg acgaaagcgg cgccgcagcc gtcgccgggg atgaccgcct
    19441 cggcgagccg gcgcacctcg gtctgggtca tcaccgggcc cgcgctgttc tgcacgttga
    19501 gcaggagcgc ggagcgggcc tggccggtgc cgatgaggac gcgggccaga cgcagcaggt
    19561 ggacgaagga ggcgcagccg ccgttgtgcg cgtcgagcac ccagtcggcg cggatgccga
    19621 gccggtgggc gacctccgcg ccgggcccgg tgaaggggac ctccggcagc agggtgttgg
    19681 tgatgaccac gtcgacgccg cgcagcgcgt cccggccgac gcggtcggcg agggtgtgcg
    19741 cggccttctc catcatgtcg gcgggcgtct cgtcccggga cacctggtgc cggaagcgcg
    19801 gcgccttgaa catggtgtgg ccggcgaggg ccgcgtcctg cgtctggtac ggcaggaagt
    19861 actccgtgcc gaccggttcg cccggcatgt aggaggcgac ctccaggagg ctcacgtccc
    19921 gcatgccggt ctccccgccg gtggcgcccc tcatgcgggg gcgccgcttc cgtgccggtg
    19981 ctccaggatc ttcttcaggt tgtcgatctc cgcctggtgg cccgcgtaga acagcggcca
    20041 catgtcgccg acccaggggc gatcgggggt ggtggcgagc tccgggtgcg ggttctcgtc
    20101 gtagtacggg tggcggcagt tggtccagat gaccacggag ccgggcctgt tcaggacgat
    20161 ctccgccggg acgatccggt ggaggtagtt catccacagc tcctcgccct ggtcccaggc
    20221 gcagcgcatg tcgacggtga gggcgttcgg gtcgccgtcg atccgcatga agatcttggt
    20281 gttgtcgtcg aggaggacgt cgcggccctg gtagacgccg gggacgtcgg tgggggcgaa
    20341 gtcgcgggtg ctgtaggtgt actcgttgag gttgcggacg tcggtgaggt agtcgtagac
    20401 cgcctgcggg ggcgcgtcga tgtactggtg gacggtgacg aaccggccgt acacctcgtc
    20461 gtaggtgaag ctgtccttcg tcatctgcgc ggcgacggcc atggcctcct cacgcggcgt
    20521 ggtctcccag cgcagcaggc cggggacgtc cttgacgccg gccgggatcg gctccggggc
    20581 gacgtagccg ggcagggggg tcgggttggt gacggaggtg gtcatcctgg tacggctcct
    20641 tctcggacgg gccgtccgcg gccggtgagc agcacgtgct gccggaacgg ccggaacggt
    20701 ggcatttcgg tggggtcgac gtccacgcag accagcgcgg gcgacgaggt ggcgtgggcg
    20761 cggtccaggg ccgcgcccag ctctcccgcg gtgcggacgg tgtcggcggc caggccgggg
    20821 aacatcgcgg cggcgccgtc gccgatccgg gccggccgga agaggttgta ggagtagtcg
    20881 ccggagaaga acagctgctc ccgggtggcg cacatgccgt gggcgttgtt gttcagcacg
    20941 acgaaggtga cgggcaggtc gtgttcgacg gccgtgtgca cctccatgcc gtgcatgaag
    21001 aacgccccgt cgccggcgat gacgcaggtg cgccggccgg tggcgaacgc cgcgcccacc
    21061 cccgcgccga agctgtggcc catgccgccc atgccgaggg cggcgatgaa ccggccgccg
    21121 gggggcacgt cgacgtggtg gatggcggcg gccccggtgt tgccggcgtc ggccacgacg
    21181 gtggcgccct cgggaaggtg ggccgcgacg gtcagggcgg ccgtgcgcag gtccagcgaa
    21241 gtcgccgggt cgggtacggc ggcggccggg cgcacgggcc gcggcgcggg ccccggctgc
    21301 cgggcggtcc gaccgggcgc cgggtgctcg gcggccgggc cggacgtcgg gcggtccgcg
    21361 gcggggccgg acgcggtggt gacctcccgc tccagcagct ccagctcggc ggcgaccggc
    21421 ccggtgaggc ggaccagctc ctcgtgggcg ccgaggaacg gctcgcgcgg gtcgacgcag
    21481 accaccggca cgcccttgag gtgctcgtgc agtccggcgc cggccatctg cggcagtcgc
    21541 gtgccggcga gcagcacggc ggacgcccgc tccagggcct cctgcacctc ggccgtgccg
    21601 atcgcgccgg cgatgccgag gtggccgggg tcgcgcgggt cggcgacgtc cttggcgtcg
    21661 gggacgaccg cgaccgccgc gcccagcgcc gcggtgagcc gggccagctg gggacgggcg
    21721 tcggcgcggg cgacggcctc gccggcgatg acggcgacac cgccgcgccg ggccgccgcg
    21781 cgcagcagcc cggcggcgcg gctccgctcg gccgcgtcgg acagcggcag cgcggccggg
    21841 gccaccgcgg cgggcgggtc ccacgacggg atgacggcct gctgcacgtc cttggggagg
    21901 agcagcacgg cgggcccggg cgccgccggg tcggtcgccg cggccagggc gcgcggcagt
    21961 tcccggacga tcgactcggg gtcgtcgacg cggacgcagt acacggccag ttcggcgaac
    22021 atccgggcgg cgtcgatcga accggcgagg ccgctggtct cctggaagga accgcggccg
    22081 tcgagcgcgg ccggcggctg cccgatcagg acgagcgccg gcacgtagga ggcgcgcagc
    22141 tcggcgatgc cggggacgag gttcatcgcg ccggcgccgg aggtggcggc gatcaccggg
    22201 acgcgctgcg acgcgcggtg gtagccgtcc gccatggtgg cggcggagaa ctcgtgcttg
    22261 gccaccaccc ccagggggcc ggcctgcgca tggtgcagcg cgtcgtagag gtcctcgatg
    22321 ttggcgccgc cgactccgaa tacatggctg acttcctgcc gttgcaggaa atccacgacg
    22381 aaatcgacca cgcggggtga acttctcatg tggccgcccc cttccgacgg tggtgcggcc
    22441 attacaggca gcgccgccga cgggcgacaa gtgaccggga tctgccggtc gacaggggcc
    22501 gcaccggcag gtttcgacca ggtgccgcgg acgcgacccg gcagtgacct gccggcccga
    22561 ggagggttcg catggcaggg atctgccatg tccgactgtc atgtatccgg ccacgtggcg
    22621 ccgttaggtt tcccggcaca tcgacgtacg aacgaatggg gaaaccaccg tgatcaccgt
    22681 cgccaccgtc tgctccctca tagagaagaa gctcggcagc aaggccgccg gcctgacgct
    22741 cgacgagaac acggcgttcg actcggtcgg cctgtccagc ctccagatcg ccgacatcgt
    22801 ctacacgatc gaggacgacg cggagatcga gctcgacccg agcgaggcgg ccaacgtcaa
    22861 gaccgtcggt gacctggtca cgctggtgga ggccacgaag tccgccggtg cggcggcatg
    22921 accaccgcga ccaccccgac caccgcgacc gacgcctacc ggggggcgac ggcggaggcg
    22981 atccggcacc actacgacgt ctccaacgac ttctacgccc tgtggctgga cgactccctc
    23041 acctacacct gcgccctgtg ggacgactcc accaccggcc tggccggggt gccggagacg
    23101 ctggagagcg cgcaggcgcg caagctggac tacctcatcg agggggccag ggcggccggc
    23161 gcccgccggg tcctggacgt ggggtgcggc tggggcagcc tgctgaagcg gctcacgggg
    23221 atctacggcg tcgagcacgc cgtgggcctg accctcagcg acagccaggc cgaactggtc
    23281 cgcggggcgg cgctgcccgg cgcggaggtc cgcgtggaga actggcgcga ccaccacccc
    23341 gaggaggggt acgacgcgat cgtctccatc ggcgcgttcg agcacttcgc caccacgggc
    23401 ctgtcccgcg ccgaacggat cgcggcgtac cgggagttct tcgagcggtg ccacgcgtgg
    23461 ctgccgccgc gcggccggat cgccctgcag accaacgtca agggcaacaa caccgtgatg
    23521 gacaaggcca c
//
