LOCUS       NZ_CP102332            22220 bp    DNA     linear   CON 12-DEC-2024
DEFINITION  Streptomyces changanensis strain HL-66 chromosome, complete genome.
ACCESSION   NZ_CP102332
VERSION     NZ_CP102332.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces changanensis
  ORGANISM  Streptomyces changanensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6817869)
  AUTHORS   Wu,H. and Han,L.
  TITLE     Streptomyces changanensis sp. nov., an actinomycete isolated from
            soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6817869)
  AUTHORS   Wu,H. and Han,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2022) College of Forestry (Academy of Forestry),
            Northwest A&F University, Northwest A&F University, Yangling,
            Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.9; Pilon v. 1.24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 187.45x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024600715.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 19:18:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,071
            CDSs (total)                      :: 5,982
            Genes (coding)                    :: 5,812
            CDSs (with protein)               :: 5,812
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 170
            CDSs (without protein)            :: 170
            Pseudo Genes (ambiguous residues) :: 0 of 170
            Pseudo Genes (frameshifted)       :: 70 of 170
            Pseudo Genes (incomplete)         :: 131 of 170
            Pseudo Genes (internal stop)      :: 9 of 170
            Pseudo Genes (multiple problems)  :: 37 of 170
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:13:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 297476
            Orig. end                         :: 319696
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102332.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22220
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22220
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22220
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12220](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12220
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(147..161)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 17.96"
                     /tool="antismash"
     gene            219..1193
                     /locus_tag="NRO40_RS01345"
                     /old_locus_tag="NRO40_01345"
     CDS             219..1193
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474786.1"
                     /locus_tag="NRO40_RS01345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01345"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_058940735.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.1e-30,
                     bitscore: 104.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEISVVVPCFDESEVIDVFHETVLAALEPTGADFELCYVDDGSR
                     DATVDRLRELARADVRVRYTSFSRNFGKEAAMLAGMRMARGAAVVLMDADLQHPPELLP
                     RMLELHQHGYDQVVAQRDRSGEGAVRKAFSRTYYRLVRRFMDVEVVDGAGDFRLLSRRA
                     VEAVLTLPESNRFSKGLFSWIGFDTVSFRYENVERAAGASKWGGRRLLNYGIDGLLSFN
                     SRPLRLAIHTGLWLFLSAFAYALWIVANALLDGVDTPGYATLITAIVGLSGVQLATLGV
                     IGEYVGRIYHESKRRPHYVVRETERDAGRRAGAGRSTARAGRP"
     gene            complement(1260..2759)
                     /locus_tag="NRO40_RS01350"
                     /old_locus_tag="NRO40_01350"
     CDS             complement(1260..2759)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849286.1"
                     /locus_tag="NRO40_RS01350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01350"
                     /product="DUF6056 family protein"
                     /protein_id="WP_058940734.1"
                     /transl_table=11
                     /translation="MAVGAPRVTDRDDEDTGRGDGPPPTGRTVPAALLALAALPLGLLV
                     MASVLGRHVRPGADEWCFLPVVRDHGIAGLVEQFYVTDNGRLANGLLVGLYAKFPVAGH
                     QWYGPVSGALMLGLLWALTALLLRRAGLAAPRGTALAVAGMTTAVFLFATPNTYKTFYW
                     PAASVSHTLAPVLAAAAALPLLRARGRRGRIAALVTVLLAGVFMGTLSEEASVVALVVL
                     AAATVLAPLVLVERVRRPFRVWALTGMAGVAVGTLLLVTSPGSRNRRERYDAETVSMLA
                     PDSLVTSLKLFARIAETVLTTWQYAGAVAAGVLLGLLVRRRPDAGPAVLLPWRPVRLLS
                     LGALVVLVCGYLCTVITYPVFGTRVLTTERTWNDYLLLYVLLLVAAGAALGRSVRRARR
                     PVVLAAAAASAAVCAATVLGLAVPLHHLGDDMRARAERWDRQDRHLREQAASGARTVPY
                     TPNSVARMLEPFGAGGKKRWPAGCVADYYHLDRVTYGGPTP"
     gene            2982..3791
                     /locus_tag="NRO40_RS01355"
                     /old_locus_tag="NRO40_01355"
     CDS             2982..3791
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474697.1"
                     /locus_tag="NRO40_RS01355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01355"
                     /product="VOC family protein"
                     /protein_id="WP_058940733.1"
                     /transl_table=11
                     /translation="MTTEPTPAATEAATSSSTVYGAPCWVTLMTRDLRAAHDFYGAVMG
                     WEFRPARLGEGFSVALSGGRAVAGIGALASAFHVAVAWTPYFAVRDADETAARIRERSA
                     TVAVGPVAFVLGRGALAADRDGAVFGIWEGELPTGWEAWRSTAPAWVRLHTRDAFDAAI
                     FYGEILDWACGRPGCCDVEYVGDEVVLRSGDRAVARLSSGALGEAPDPAIRPRWQVHFP
                     VSDVERGVTVALRHGGTVITHEPGVQATLRDPDGGLFTLTDAAAADG"
     gene            complement(3951..4985)
                     /locus_tag="NRO40_RS01360"
                     /old_locus_tag="NRO40_01360"
     CDS             complement(3951..4985)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (53-172). E-value:
                     1.5e-08. Score: 26.0. Matches aSDomain:
                     nrpspksdomains_NRO40_RS01360_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174350.1"
                     /locus_tag="NRO40_RS01360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01360"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_058940732.1"
                     /transl_table=11
                     /translation="MTAPQGKRIVVTGATGNVGTSVVTALTADDRVASVLGLARRRPDW
                     SPPRTEWARADIEKDGDREFAELLAGADAVVHLAWAFQPTHDPLATWRTNVLGGMRVFR
                     AVAEAGVPALVYASSVGAYSPGPKDRYVDESWPTHGWPEAAYSREKAYLERVLDGFEAR
                     HPEVRVVRLRPAFLFKEAAALEQLRIFAGPWVPGRLASPRFLPVVPDIEGLRFQALHTD
                     DAADAYRRAALDDDARGAYNLAAEPPVGPEELAALLDARVVRLPRPAVRAALSAAWRLR
                     LARSSPQLFDAFLRLPLMDASRARDELGWRPRYTALEAVGELLRGLRGGAGMPTAPLHG
                     RGGR"
     aSDomain        complement(4470..4826)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NRO40_RS01360_NAD_binding_4.1"
                     /evalue="1.50E-08"
                     /label="NRO40_RS01360_NAD_binding_4.1"
                     /locus_tag="NRO40_RS01360"
                     /protein_end="172"
                     /protein_start="53"
                     /score="26.0"
                     /tool="antismash"
                     /translation="RADIEKDGDREFAELLAGADAVVHLAWAFQPTHDPLATWRTNVLG
                     GMRVFRAVAEAGVPALVYASSVGAYSPGPKDRYVDESWPTHGWPEAAYSREKAYLERVL
                     DGFEARHPEVRVVRL"
     misc_feature    4981..4996
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    5205..5216
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     gene            5299..6768
                     /locus_tag="NRO40_RS01365"
                     /old_locus_tag="NRO40_01365"
     CDS             5299..6768
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524493.1"
                     /locus_tag="NRO40_RS01365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01365"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_058940731.1"
                     /transl_table=11
                     /translation="MPSPLFADRPSPQPPRRGAVDALISQTRRLRGEVDAVRRDAGADE
                     DDPRLRWRRALCDLAVHQLDDLRAHLGQLRDGVPEHLTPHGVAARGSGASARDGRPSGE
                     AATGSLLSRVGSAEWNLLTDEVRWSDELFAIFGRPPAAGPMSLDELPSVVFAEDQPRLT
                     QLVTGCLVDGKPIDGEFRVVRADGRVRTLHMVGEPVLDGDGRTASMWAVLRDVSELRRS
                     ERAVRESGDSLRRRREVEHAEHRAAVELQEAVLPPWRGPLPLAGDAPAPLDLAGHYLPS
                     GSSTRIGGDWYDALELPDGDVLLSVGDLTGHGVLATSAMAMLLGALRGLAVAGIEPGAL
                     LGHLNRLMESSAQPALAGALCCRYAPGTGTLRWAQAGHPAPLLFRDGTGCALTAPKGVL
                     LGATPGSAYEQAEARLRPGDVLLLHTDGLTRGAAGPGQDAPGTERLLGLAPRFARARDA
                     QECVRAVVEEFGDGERTDDACVVVARIGAPS"
     gene            complement(6874..8370)
                     /locus_tag="NRO40_RS01370"
                     /old_locus_tag="NRO40_01370"
     CDS             complement(6874..8370)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069082.1"
                     /locus_tag="NRO40_RS01370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01370"
                     /product="hypothetical protein"
                     /protein_id="WP_058940730.1"
                     /transl_table=11
                     /translation="MTGQPNARLCDLFGLAGWSKGELARLVNRQAAAMGHPQLATDTSR
                     VRRWIDMGEIPRDPVPRVLAALFTERLGRVVTIEDLGFVRHGRAGKRRDVRQTDNPDEL
                     PWAPERTATVLTEFTGMDLMLNRRGLVGAGAALTAGSAIASSLHDWLRTDPRKTDTPGH
                     GLSDPLHADPAGHDRYEAAPIGWQEIDELETSVEVFRAWDAARGGGLQRKAVVGQLNEV
                     GGMLAYRHSEPIQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFIIAAHAAREGGDLPR
                     AGEALSRAARQMVHLGRPDEALDLMQLAKSGSGEQVLPRTQAMLHTIEAWAQAAMGRGQ
                     AMRRTLGEAEDLFVSDRGDVPLPSWMQTFKNEDLYGMQALAYRTLAEHEPAAAKQAQYY
                     AQKAMELRVDHRKRSLIFDHLSMASACFIADDPEQADRYARLALSAMGANSSQRTWDRL
                     REMYRLTARYADYAKIKDLRERIEVALPKDQARKLGPRSV"
     gene            8602..9717
                     /locus_tag="NRO40_RS01375"
                     /old_locus_tag="NRO40_01375"
     CDS             8602..9717
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="NRO40_RS01375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01375"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_058940729.1"
                     /sec_met_domain="APH (E-value: 1.1e-15, bitscore: 56.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPRTVPVGGGPYLGPAQAGRARRWAGTVTGPLS
                     GRIDLSGPQGAQLRKAIASVHRICPEFNPVQVMRRSGRSVLLVGTTGRATAVAKCLLDH
                     SPVWVERFQHEIAAYRTFVRHRPPVRVPRLIAADPENGTLVIERMPGRAAALSRHPVEA
                     PPRADIRAVLGSVARLNAWRPPAGTFDAPLDYASRISRYHELGLFTDRDRDDLQKLLHG
                     LAQAGGRQGMGQFCHGDALLSNMLLSPAGPVLVDWEHAGWYLPGYDLATLWAVLGDAPV
                     ARRQISQHAQAAGPAARDAFLVNLMLVLTREIRTYETAVQRTMREAPPAGSIPIQPGAV
                     SPGEEQRLLLRRLHDDCALARRAVRAAVGTR"
     misc_feature    complement(9982..9996)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     gene            10001..12220
                     /locus_tag="NRO40_RS01380"
                     /old_locus_tag="NRO40_01380"
     CDS             10001..12220
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044184.1"
                     /locus_tag="NRO40_RS01380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01380"
                     /product="terpene synthase family protein"
                     /protein_id="WP_058940728.1"
                     /sec_met_domain="T1TS (E-value: 1.2e-84, bitscore: 283.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFALPEFYVPYPARLNPHVDAARVHTREWARHMGMLEGSGIW
                     DQDDLDSHDYALLCAYTHPDCDAEALSLVTDWYVWVFFFDDHFLETFKRTLDRAGGKAY
                     LDRLPAFMPTDPSAPVPEPENPVEAGLVDLWARTVPAMSSAWRERFAVATENLLNESLW
                     ELSNIDEGRIANPVEYIEMRRKVGGAPWSAGLVEYAAGAEVPASVAESRPLRVLRDAFS
                     DAVHLRNDLFSYQREVEDEGENSNGVLVLERFLGCSTQEAADAVNDLLTSRLQQFEHTA
                     LTEVAPLCAEKGLDPRETAAVLAYAKGLQDWQSGGHEWHMRSSRYMNEGAVGADPGGGA
                     FGMAAASIRLTPRAEAARWRGFSHVPFQRVGPSLLPHVEMPFQVTHNRHLEGARGRCVE
                     WGRAMGFLREQPGQPGSGVWNERKIAGYDLPLCAAGLHPTASADDLDLASHWLAWGTYG
                     DDLYPVVYGRTSDLASARAQNDRLKSLMPLDAAATDVPAPANALERGLADLWPRTVGPM
                     AERDRAAFRDAVCVMIDSWEWELVNQAHHRIPDPVDYIEMRRATFGSDMTIALCRIGHG
                     NRVPPEVYLSGPVRSLENAAIDFATLLNDLYSYQKEIEFEGEVHNCVLVVQRFFDVDHP
                     TAVAMTGELMNSRMRQFQHVAAHEFPVLYEDFGLDRETRAVLDGYVRELENWMAGIHTW
                     HRDCKRYQEEVLLQDRAEALAGAPSLGGPTGLGTSAARVAALLVP"
     misc_feature    complement(10002..10017)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            complement(12427..12825)
                     /locus_tag="NRO40_RS01385"
                     /old_locus_tag="NRO40_01385"
     CDS             complement(12427..12825)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474689.1"
                     /locus_tag="NRO40_RS01385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01385"
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="WP_058940727.1"
                     /transl_table=11
                     /translation="MAVTDEAQANAGVRVDSWIWAVRLTKTRSQAATACRAGHVRVNGD
                     RAKPAQTVKPGDEVRVFHAGRERVVEVRRALAKRVGAPVAAEAYTDRTPAPPPREHVAL
                     AAVRERGAGRPTKRERRELDQLRGARRP"
     gene            complement(12846..13346)
                     /locus_tag="NRO40_RS01390"
                     /old_locus_tag="NRO40_01390"
     CDS             complement(12846..13346)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="NRO40_RS01390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01390"
                     /product="hypothetical protein"
                     /protein_id="WP_058940799.1"
                     /transl_table=11
                     /translation="MSFLRRRSPATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLFGGRGPAMIIGNLPEGSPARDIANGQIPFEVAQLLAALDMDDHVEVAETEDV
                     PVMQGDNLLIVRRLKLTESRISCVQFDRSDNVLVTIASWDRPITDDLYALLKPLPAELF
                     QQG"
     gene            13910..15205
                     /gene="paaK"
                     /locus_tag="NRO40_RS01395"
                     /old_locus_tag="NRO40_01395"
     CDS             13910..15205
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (91-334). E-value: 7.7e-22.
                     Score: 69.3. Matches aSDomain:
                     nrpspksdomains_NRO40_RS01395_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474685.1"
                     /locus_tag="NRO40_RS01395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01395"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_058940726.1"
                     /sec_met_domain="AMP-binding (E-value: 4.4e-25, bitscore:
                     86.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEDLRDAGERMGRDELAAVQRERLRATLRHAYENVPFYRRAFDA
                     AGVRPEECASPADLARFPFTTKADLRDQYPFGMFAVERSRVRRLHASSGTTGQPTVVGY
                     TERDLDVWADVVARSIRAAGGRPGQVVHVAYGYGLFTGGLGAHGGAERLGCTVVPASGG
                     MTARQVRLIQDFRPEVIMVTPSYMLTLLDEFERQGVDPRSTSLKVGIFGAEPWTEEMRR
                     EIEERCAIDAVDIYGLSEVIGPGVAQECVETKDGLHVWEDHFYPEVVDPVTGEVLPDGE
                     RGELVFTSLTKEAMPLVRYRTRDLTRLLPGTARPAFRRMEKVTGRSDDMVILRGVNLFP
                     TQIEEVVLRTPGLAPHFQLRLTREGRLDALTVRVEARPGTAPPRRAEAAREVEAAVKEG
                     VGVTVTVDVVAPETLERSVGKIKRIVDLRTQG"
     aSDomain        14183..14911
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NRO40_RS01395_AMP-binding.1"
                     /evalue="7.70E-22"
                     /label="NRO40_RS01395_AMP-binding.1"
                     /locus_tag="NRO40_RS01395"
                     /protein_end="334"
                     /protein_start="91"
                     /score="69.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SSGTTGQPTVVGYTERDLDVWADVVARSIRAAGGRPGQVVHVAYG
                     YGLFTGGLGAHGGAERLGCTVVPASGGMTARQVRLIQDFRPEVIMVTPSYMLTLLDEFE
                     RQGVDPRSTSLKVGIFGAEPWTEEMRREIEERCAIDAVDIYGLSEVIGPGVAQECVETK
                     DGLHVWEDHFYPEVVDPVTGEVLPDGERGELVFTSLTKEAMPLVRYRTRDLTRLLPGTA
                     RPAFRRMEKVTGRSDDMVILR"
     CDS_motif       14879..14941
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NRO40_RS01395_0001"
                     /evalue="4.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="NRO40_RS01395"
                     /protein_end="344"
                     /protein_start="323"
                     /score="13.0"
                     /tool="antismash"
                     /translation="TGRSDDMVILRGVNLFPTQIE"
     misc_feature    15230..15245
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            15256..17676
                     /locus_tag="NRO40_RS01400"
                     /old_locus_tag="NRO40_01400"
     CDS             15256..17676
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849637.1"
                     /locus_tag="NRO40_RS01400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01400"
                     /product="penicillin acylase family protein"
                     /protein_id="WP_058940725.1"
                     /transl_table=11
                     /translation="MDQLTSSAVLLGGTVLLRTHLRRLLPAAVALLATAATTLPATAAG
                     PPAEGRNPSAGGLSATIRYTEYGIPHILARDYAGLGFGTGWAQAADQACVLADGFVTVR
                     GERSRYFGPDAVPDGSLSSARRNLSSDLYFTGVREARTVERLLARPAPAGPSRTQKELM
                     RGWAAGYNAWLAKNRVTDPACAGKPWVRPVTPLDVARRSYALAVLGGQGAAVEAITAAA
                     PPAAGPAAGPAPDARRLAEAARGMFDERTATMGSNAVAFAGGTTANGRGLLLGNPHYPW
                     HGGRRFWQSQQTIPGELNVQGASLLGAPLVQIGFSDKVAWSHTVATGRTFNLHQLSLDP
                     ADPTAYVVDGRSERMVRRTVTVPVASGDPVTRTQWWTRYGPVVTAFAGDPLPWTATTAY
                     ALHDPNAENLRMADTSLGLAKARSTRDVERALRRTQGLPWVNTVASDRNGGTLFAQAQV
                     LPRITDELAERCSTPLGRALYPAAGIAVLDGSRGACALGRDRDAVQPGIMGPSRWPVLR
                     DAAYAENSNDSAWLANADRPFTRYERVFGDIGTERSLRTRGAIEDVAAMADRGGLTVAD
                     LQRQQFANRVPAADLTADDVVRACPAALPDEPAACGALARWDRRVDTTSRGALLFDRFW
                     LRLQREVPGPDRWKVPFSAADPVGTPRSLNTAAPGFATALRGAVTEVRAAGIPFDAPLG
                     EHQYVVRGGERIPVHGGTGTGVWNMTVPVWDAARGAYTEVQHGTSHVQAVGWDDSRCPV
                     ARTLLSYAQSSDPGSPHHADQTRLYSQERWVTARFCERDILSDPALRVVRVAQ"
     misc_feature    15346..15348
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17680..18831)
                     /locus_tag="NRO40_RS01405"
                     /old_locus_tag="NRO40_01405"
     CDS             complement(17680..18831)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474682.1"
                     /locus_tag="NRO40_RS01405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01405"
                     /product="calcium:proton antiporter"
                     /protein_id="WP_079046827.1"
                     /transl_table=11
                     /translation="MGKQTDADRGGPGGADGGAATPRPWRERTTWVPAVAVLVLALCWG
                     RDLPGVLVAVVGLCLAGAVLSAVHHAEVVAHRVGEPFGSLVLAVAVTVIEVGLIVMLMA
                     SGGDSAATYARDTVFAAVMITCNGIVGASLLVATLRGRRVAVFNAEGSGGALATVTTLA
                     TTTLVLPTFTTGSRGPEFTGAQLAFAAVASLCLYGLFVTVQTVRHRDYFLPVARTGEPL
                     DAVAHAVPPTRAATWWSLGLLAVALVAVVGLAKVVSPTIESGVETAGLPTAVVGVVIAL
                     MVLLPETLAAVRAARGERVQTSLNLAYGSAIASIGLTVPVIALASLWLSGPLVLGLGPV
                     HLVLLALTAVVSALTVVPGRATLLQSGVHLVLFAAFVFLSFSP"
     misc_feature    complement(18821..18834)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     misc_feature    complement(19032..19048)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.24"
                     /tool="antismash"
     gene            19097..20923
                     /locus_tag="NRO40_RS01410"
                     /old_locus_tag="NRO40_01410"
     CDS             19097..20923
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606706.1"
                     /locus_tag="NRO40_RS01410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01410"
                     /product="serine hydrolase"
                     /protein_id="WP_058940724.1"
                     /transl_table=11
                     /translation="MGREPAGGHGIGRRAFGGGVLALGGALVIGPVPGVRGAQPERPGS
                     GPHGAGHGAGPVLRRGTAERAGLLPDHLDRLVDDAERFLGPSPTHPWYAGAVVLAGRGT
                     TVALHRAVGYALRYAAYDETTDRGVELPPERRIPMHEDTVFDLASLTKLFTSLLVVQLL
                     ERGELELEGRVAERLPEFGGGGKGGVTVRQLLTHTSGLRAWLPLYREPTREGRLRMLWE
                     ERPTDAPGTLYRYSDLNLIALQLLLEEVTGRPLDVLLRERITGPLGMRRTRFAPPASWR
                     PRIAATEDARPPWSGLDRGLVWGEVHDENAHAFGGVAGHAGVFSRAWDLAVLARTLLNG
                     GAYGRARILRPDSVELLFTDFNTAFPGDEHGLGFELYQHWYMGAMATPRSAGHTGFTGT
                     SLVLDPTTDAFLVLLGNSVHPVRTWRSGSAPRVAVADRLARAVPVRAAHGRTAWFSGMA
                     SATTATLTLPAVRPATARARLRCALWWDTEPGTDALVLEASATDASEGAVWRPVPFTTV
                     PPGGEPAAHPGGAVSGWSGRVWHRAEADLSAWSGSGPVRLRWRYTTDGRYVGRGAYVDR
                     LRVLDGDDALFDEARPADAARVEARGWVPSAD"
     gene            21071..21271
                     /locus_tag="NRO40_RS01415"
                     /old_locus_tag="NRO40_01415"
     CDS             21071..21271
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946066.1"
                     /locus_tag="NRO40_RS01415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NRO40_01415"
                     /product="antitoxin"
                     /protein_id="WP_058940723.1"
                     /transl_table=11
                     /translation="MAMMDKLKSMLKGHEGQSSRGVDKVGDMVGRRTRGKHSRHVGTAQ
                     ERLKDQLGRRRGGHGGEPPRP"
     gene            21437..21613
                     /locus_tag="NRO40_RS01420"
                     /old_locus_tag="NRO40_01420"
     CDS             21437..21613
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NRO40_RS01420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NRO40_01420"
                     /product="hypothetical protein"
                     /protein_id="WP_157901785.1"
                     /transl_table=11
                     /translation="MLRRISIALAGLLAVGFLTASPAAADSDGVKGCWVSGGHVSAGDV
                     HVAGFEGTCWRVG"
     misc_feature    complement(21471..21486)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.61"
                     /tool="antismash"
ORIGIN
        1 atggggggcc ggggccgttc gcgtacgcgc ggggcagccc gaccacacgc gcaaccgtgc
       61 ggggggcacc cgggtgggtg acccgggtgg tggcgggcgc gcgggtgtgc ggcgctggta
      121 gcgaggtgaa ggcaacctcg gcggcccggc ccgcatcttc cccgtgcggc gggtaccgga
      181 ggggcgtccc gcatcggcgt gcatggagtg ggtcagcaat ggtggagatc tcggtcgtcg
      241 ttccgtgttt cgacgaaagc gaggtgatcg acgtcttcca cgagacggtg ctggccgcgc
      301 tggagccgac gggggcggac ttcgagctct gctacgtgga cgatggcagc cgcgacgcga
      361 ccgtcgaccg gctgcgggaa ctggcccgcg ccgacgtgcg cgtccgctac acgtccttca
      421 gccggaactt cggcaaggag gcggcgatgc tcgccgggat gcggatggcg cggggcgccg
      481 ccgtggtgct gatggacgcc gacctccagc acccgccgga gctgctgccc cgcatgctgg
      541 agctgcacca gcacggctac gaccaggtgg tggcccagcg ggaccggtcc ggtgagggcg
      601 cggtccgcaa ggcgttcagc cggacgtact accgcctggt gcggcggttc atggacgtcg
      661 aggtcgtcga cggcgccggt gacttccggc tcctgtcgcg ccgcgccgtc gaggcggtcc
      721 tgaccctccc ggagagcaac cgcttctcca agggtctgtt ctcgtggatc ggcttcgaca
      781 ccgtgagctt ccgctacgag aacgtggagc gggccgccgg agcgtccaag tggggcggca
      841 gacggctgct gaactacggc atcgacgggc tgctgtcgtt caacagccgg ccgctgcggc
      901 tggccatcca caccgggctg tggctgttcc tgtcggcgtt cgcctacgcc ctgtggatcg
      961 tggcgaacgc gctgctggac ggggtcgaca cccccggcta cgcgacgctg atcacggcca
     1021 tcgtggggct gagcggggta cagctggcga cgctcggcgt gatcggcgag tacgtcgggc
     1081 ggatctacca cgagtccaaa cggcggccgc actacgtggt gcgggagacc gagcgggacg
     1141 ccgggcgccg ggcgggggcc ggccggtcca cggcccgggc gggccgcccc tgaccgggcg
     1201 gtccgctccc cgggggaccg ccggacgccg ccggcccgcc gggtcttccc ggacggggcc
     1261 tacggggtcg gcccgccgta ggtgacccgg tcgaggtggt agtagtcggc gacgcacccc
     1321 gccggccacc gcttcttgcc gcccgcgccg aacggctcca gcatccgggc gacggagttg
     1381 ggggtgtacg ggacggtccg ggcgccgctc gcggcctgtt cccgcaggtg gcggtcctgc
     1441 cggtcccagc gctcggcgcg cgcccgcatg tcgtcgccga ggtggtgcag cggcacggcc
     1501 agccccagga cggtcgcggc gcacacggcg gccgacgcgg ccgcggcggc gaggaccacg
     1561 ggccgccgcg cgcggcgcac ggaccggccc agggcggcgc ccgcggcgac gagcagcagc
     1621 acgtacagca gcaggtagtc gttccaggtg cgctccgtgg tgaggacccg ggtgccgaag
     1681 accgggtagg tgatcacggt gcacaggtat ccgcagacga ggacgaccag ggcgccgagg
     1741 gagagcagcc gcaccggccg ccagggcagc aggacggcgg ggcccgcgtc cgggcggcgc
     1801 cgcacgagca gccccagcag gacgcccgcg gcgacggccc ccgcgtactg ccaggtcgtc
     1861 aggacggtct ccgcgatccg ggcgaacagc ttcagcgagg tgacgaggga gtcgggggcg
     1921 agcatggaga cggtctcggc gtcgtagcgc tccctgcggt tgcgcgaccc gggcgaggtg
     1981 accagcagca gcgtgccgac cgccacgccc gccattccgg tcagcgccca gacgcggaac
     2041 gggcgccgga cgcgctcgac gaggacgagg ggggcgagga cggtggcggc tgcgaggacg
     2101 acgagggcga cgaccgaggc ctcctccgac agggtgccca tgaagacccc cgcgaggagg
     2161 acggtcacga gcgccgcgat ccggccgcgg cggccccggg cgcgcagcag cggcagggcg
     2221 gccgcggcgg ccaggaccgg ggcgagggtg tgcgagacgg aggcggcggg ccagtagaag
     2281 gtcttgtacg tgttgggggt cgcgaagagg aacaccgcgg tggtcatccc ggccaccgcg
     2341 agcgccgtgc cgcgcggggc ggcgagcccg gcgcggcgca ggagcagggc ggtgagcgcc
     2401 cacagcaggc cgagcatcag ggcgccgctg acggggccgt accactggtg ccccgccacg
     2461 gggaacttcg cgtagaggcc gacgagcagg ccgttggcga ggcggccgtt gtcggtgacg
     2521 tagaactgtt cgacgaggcc ggcgatgccg tggtcgcgga ccacgggcag gaagcaccac
     2581 tcgtccgctc cggggcgcac gtggcggccg aggacggagg ccatcaccag cagccccagg
     2641 ggcagggccg cgagggcgag gagcgccgcg ggcaccgtgc gcccggtggg cggcgggccg
     2701 tccccccgcc ccgtgtcctc gtcgtcgcgg tcggtgacgc ggggcgcgcc gacggccatt
     2761 ctcaccactg cctttcgggg ggaaacactg atccgccacc gtagagggca ttcgccgcgc
     2821 tcccgttccg tccatggcgc ggcacgccgc gtcgtcggtg cgtcggtgcg tcggtgcgtc
     2881 ggtgcgatga aaggaggcga aaggggcatt cggcgtgtaa acggtggaag gatggagtgc
     2941 gggcgcgacg cgcgaggcga caccgggacg gttggcagca catgacgaca gaacccacac
     3001 ctgccgcgac agaggcggcg acatccagca gcacggtcta cggcgcgccg tgctgggtca
     3061 cgctcatgac ccgggacctg cgcgcggcgc acgacttcta cggggccgtc atggggtggg
     3121 agttccgccc cgcgcggctc ggcgaggggt tcagcgtcgc gctctccggc ggccgggccg
     3181 tcgccgggat cggcgcgctg gcgtccgcct tccacgtggc ggtggcgtgg acgccgtact
     3241 tcgccgtgcg ggacgcggac gagaccgcgg cacgcatccg ggagcgcagc gcgacggtcg
     3301 cggtcggtcc ggtcgcgttc gtcctgggcc gcggggcgct ggccgcggac cgcgacgggg
     3361 cggtgttcgg catctgggag ggcgagctgc ccaccgggtg ggaggcgtgg cggtcgacgg
     3421 cgcccgcgtg ggtgcggctg cacacccggg acgcgttcga cgcggcgatc ttctacgggg
     3481 agatcctcga ctgggcgtgc gggcggcccg gctgctgtga cgtggagtac gtcggcgacg
     3541 aggtcgtgct gcgcagtggc gaccgggcgg tggcgcggct gtcgtccggc gcgctgggcg
     3601 aggcccccga cccggccatc cggccgcgct ggcaggtgca cttccccgtc tcggacgtgg
     3661 agcggggcgt cacggtcgcg ctgcggcacg gcggcacggt gatcacccac gagcccgggg
     3721 tgcaggcgac cctgcgcgac ccggacggcg ggctgttcac cctgacggac gccgcggcgg
     3781 ccgacggctg acggctgacg gctgacggct gacggctgac ggccgaccgc cggtgacccc
     3841 gcggtttctc cccggcggcc ggcgcgccgc cgggcgaggg gccggcctcg cgggtccgcc
     3901 ggggcgaaga ctccggcttg gcgcgtccgc cggggcgcgg ggccgggcgg tcagcgaccc
     3961 ccgcggccgt gcaggggcgc ggtcggcatg ccggcccctc cgcgcaggcc ccggagcagt
     4021 tccccgaccg cttccagggc ggtgtaccgg ggccgccagc ccagctcgtc gcgggcgcgg
     4081 gaggcgtcca tgagcggcag ccgcaggaag gcgtcgaaca gctgcggcga ggaccgcgcc
     4141 aggcgcagcc gccaggcggc gctcagcgcg gcgcggacgg cggggcgcgg caggcggacc
     4201 acgcgggcgt cgaggagggc ggcgagctcc tccgggccga cggggggctc cgccgcgagg
     4261 ttgtacgcgc cgcgggcgtc gtcgtcgagg gccgcgcggc ggtaggcgtc ggcggcgtcg
     4321 tcggtgtgca gggcctggaa gcgcaggccc tcgatgtcgg gcacgaccgg caggaaccgg
     4381 gggctcgcga ggcggccggg cacccagggc cccgcgaaga tgcgcagctg ttcgagggcg
     4441 gccgcctcct tgaagaggaa ggcggggcgg aggcggacca cgcggacctc cgggtggcgc
     4501 gcctcgaagc cgtccagcac gcgctccagg tacgccttct cgcggctgta cgcggcctcc
     4561 ggccagccgt gggtgggcca ggactcgtcg acgtaccggt ccttcggccc cggcgagtag
     4621 gccccgacgg acgaggcgta caccagcgcg ggcacgcccg cctcggccac cgcgcggaag
     4681 acgcgcatgc cgcccaggac gttggtgcgc caggtcgcca gcgggtcgtg ggtgggctgg
     4741 aacgcccagg ccagatggac cacggcgtcg gcgccggcga ggagctcggc gaactcccgg
     4801 tcgccgtcct tctcgatgtc ggcccgcgcc cactcggtgc ggggcggtga ccagtcgggg
     4861 cgccggcggg cgagcccgag gacggacgcg acccggtcgt ccgcggtgag cgcggtgacg
     4921 acgctcgtcc cgacgttccc ggtggcaccg gtgacgacga tcctcttgcc ctggggtgcg
     4981 gtcacggctg cgtccctccg tcctgctccg ccggggcacg cggacgcgcg ccccgggggt
     5041 gccgagtacc cggttcgcgc cggttcacct ccggtggcac cgcgggtcgc ggccgggccg
     5101 tggagcgccg gtccggcgcg tgcgtcacca gggatccggc cagcgtggcc ggaagcccgt
     5161 cggccgcagg catatgccat gagcaccacc ggatcgagtg tggcgaaatc ccttacgacc
     5221 ggtcctgagc tgtgtcagag tcgatagccg gtccttgctc tccaggcccc ggccaccgcg
     5281 cccgtatcgg agtaccagat gccgtccccc ctcttcgcgg accgtcccag cccgcagccg
     5341 ccgcggcgcg gcgcggtgga cgccctcatc tcgcagacgc gccgtctgcg cggcgaggtg
     5401 gacgccgtgc ggcgggacgc cggggccgac gaggacgacc cccggctccg ctggcggcgc
     5461 gccctgtgcg acctggccgt ccaccagctc gacgacctgc gggcccacct cggccagctc
     5521 cgggacggcg ttcccgagca cctgacgccc cacggcgtgg cggcccgcgg ctcgggggcg
     5581 agcgcccggg acggccgccc gtcgggggag gcggccaccg gctccctcct gagccgtgtc
     5641 ggcagcgccg agtggaacct cctcacggac gaggtcaggt ggtccgacga gctgttcgcc
     5701 atcttcgggc gcccgcccgc ggcgggcccg atgtcgctcg acgagctgcc gtcggtggtc
     5761 ttcgccgagg accagccgcg gctcacccag ctggtgacgg gctgcctggt cgacggcaag
     5821 cccatcgacg gggagttccg cgtcgtacgg gccgacggtc gggtgcgcac gctgcacatg
     5881 gtcggtgagc cggtgctcga cggcgacggc cgcacggcgt ccatgtgggc cgtcctgcgg
     5941 gacgtgagcg aactgcgccg cagcgagcgc gccgtccgcg agtcggggga ctcgctgcgc
     6001 cgccggcgcg aggtcgaaca cgcagagcac cgcgcggcgg tggagctcca ggaggcggtc
     6061 ctgccgccgt ggcgcggccc cctgccgctc gccggggacg cccccgcacc gctggacctc
     6121 gccgggcact acctcccctc cggcagcagc acgcgcatcg gcggcgactg gtacgacgcg
     6181 ctggagctcc ccgacgggga cgtgctcctc tccgtcggcg acctcacggg ccacggggtc
     6241 ctcgcgacct ccgccatggc catgctcctc ggcgcgctgc gggggctcgc cgtcgccggc
     6301 atcgagccgg gggcgctcct gggtcacctg aaccggctga tggagtcctc ggcccagccc
     6361 gcgctcgccg gcgccctgtg ctgccgctac gcaccgggga cggggacgct gcggtgggcg
     6421 caggccggac accccgcccc gctgctcttc cgcgacggga cggggtgcgc gctgaccgcc
     6481 ccgaagggcg tcctgctggg cgcgacgccg ggctccgcct acgagcaggc cgaggcccgg
     6541 ctgcgccccg gtgacgtgct gctgctccac acggacgggc tcacccgcgg cgcggccgga
     6601 cccgggcagg acgcgcccgg cacggagcgc ctgctgggac tggccccgcg gttcgcccgc
     6661 gcgcgcgacg cgcaggagtg cgtgcgggcg gtggtcgagg agttcggcga cggggagcgc
     6721 acggacgacg cctgcgtcgt ggtcgccagg atcggcgccc cgtcgtaagc cggtcgcgcc
     6781 cccggcgcgg gggacggcgt gcgtggtgcg gcgtgcggat gggtgtggtg gggcgtacgg
     6841 gtgagtggcg ggagcggccg gtggccgtcc cggctagacg gagcgcgggc cgagcttcct
     6901 ggcctggtcc ttcggcaggg ccacctcgat gcgctcccgc aggtccttga tcttggcgta
     6961 gtccgcgtac cgggccgtga gccggtacat ctcgcgcagc cggtcccagg tgcgctggga
     7021 ggagttggcg cccatcgccg acagggcgag acgggcgtac cggtcggcct gctccgggtc
     7081 gtcggcgatg aagcaggcgg aggccatgga caggtggtcg aagatgagcg accgtttgcg
     7141 gtggtcgacg cgcagttcca tggccttctg ggcgtagtac tgcgcctgtt tcgccgcggc
     7201 cggctcgtgc tcggcgagcg tccggtaggc gagcgcctgc atgccgtaca ggtcctcgtt
     7261 cttgaaggtc tgcatccagc tgggcagcgg gacgtcgccc cggtcggaga cgaacaggtc
     7321 ctccgcctcg ccgagggtgc gccgcatggc ctggccgcgt cccatggcgg cctgggccca
     7381 cgcctcgatg gtgtgcagca tcgcctgcgt gcggggcagg acctgctcgc ccgaaccgga
     7441 tttggcgagc tgcatcaggt ccagcgcctc gtcggggcgg ccgaggtgga ccatctggcg
     7501 ggccgcgcgg gacagggcct cgcccgcgcg gggcaggtcg ccgccctcgc gggccgcgtg
     7561 cgcggcgatg atgaagtact tctgcgccgt cggttccagg ccgacgtcgt gggacatcca
     7621 gcccgccagg acggccaggt tggcggcgac gccccacagg cgccgctgga tgggctcgga
     7681 gtggcggtag gcgagcatcc cgcccacctc gttgagctgg ccgacgacgg ccttgcgctg
     7741 gaggccgcca cccctggccg cgtcccaggc gcggaacacc tcgacggacg tctccagttc
     7801 gtcgatctcc tgccacccga tgggagcggc ctcgtagcgg tcgtgtccgg cggggtcggc
     7861 gtgcagggga tcggacaggc cgtggccggg ggtgtcggtc ttccgggggt cggtacggag
     7921 ccagtcgtgc agggagctgg cgatggcgga gcccgcggtg agcgcggcac ccgcgcccac
     7981 caagccgcgt cggttgagca tgaggtccat tcccgtgaat tcggtgagga ccgtggccgt
     8041 gcgttcgggc gcccagggca gctcgtcagg gttgtcggtc tgcctgacat cccgccgttt
     8101 cccggcgcgc ccgtgccgta cgaacccgag gtcctcgatg gtcacgacac ggccgagtcg
     8161 ctcggtgaac agggccgcca gcaccctcgg caccggatcg cgcgggatct cccccatgtc
     8221 gatccagcgc cgcacccgcg aggtgtccgt cgccagctgc gggtggccca tggccgccgc
     8281 ctgccggttc accagccgcg cgagttcgcc cttggaccag ccggcgaggc cgaacaggtc
     8341 gcagaggcgg gcgttgggtt gtcctgtcac gtcaagcccc caggttctcg gctgagttga
     8401 cagtagcccg ccgccatggg ggtggcgact attcgccagg gttcgccagg gtgcgcaaga
     8461 tggttagcca cccgcgggcg ggtgtcaggt aggaaagcgc caccccgtcc cggcgacggc
     8521 cctcattccc cagggtgtcg accggcgacg ggacggggca gcgtacgcag tcgtcggcac
     8581 acgaagggat ctgtttcgcc catgtacaca gcatcgtcct ccgtgtccgc cccgccccgg
     8641 ccccgcaccg tcccggtcgg cggcggaccg tacctgggcc ccgcccaggc gggccgggcc
     8701 aggcgctggg cggggacggt gaccggcccg ctcagcggca ggatcgacct gtccggtccg
     8761 cagggggccc agttgcggaa ggccatcgcg tcggtccacc gcatctgccc cgagttcaac
     8821 ccggtgcagg tgatgcggcg cagcgggcgc tccgtcctgc tcgtcggcac gaccggtcgg
     8881 gccacggcgg tcgcgaagtg tctgctggac cactcccccg tgtgggtcga gcggttccag
     8941 cacgagatcg ccgcctaccg gaccttcgtg cggcaccgtc cgccggtgcg cgtgccccgg
     9001 ctgatcgcgg cggacccgga gaacggcacg ctcgtcatcg agcggatgcc cgggcgggcc
     9061 gcggcgctga gccgccaccc ggtcgaggcg ccgccgcggg cggacatccg cgccgtcctc
     9121 ggctcggtcg cccggctcaa cgcgtggcgg ccgccggccg ggacgttcga cgcgcccctc
     9181 gactacgcgt cgcggatctc gcgctaccac gagctggggc tcttcactga ccgggaccgc
     9241 gacgacctgc agaaactgct ccacggcctg gcgcaggccg gcggccggca gggcatgggc
     9301 cagttctgcc acggcgacgc gctgctgtcg aacatgctgc tgtcgccggc cggccccgtg
     9361 ctcgtcgact gggagcacgc gggctggtac ctgccggggt acgacctggc gaccctgtgg
     9421 gccgtgctcg gtgacgcgcc ggtggcgcgg cggcagatca gccagcacgc ccaggcggcc
     9481 gggcccgcgg cgcgtgacgc gttcctggtg aacctgatgc tcgtgctgac gcgggaaata
     9541 cggacgtacg agacggcggt gcagcgcacc atgcgggagg caccgccggc cggctcgatc
     9601 ccgatccagc ccggggcggt gtcccccggg gaggaacagc ggctgctgct gcgacggctg
     9661 cacgacgact gcgcgctggc gcggcgggcc gtgcgggcgg cggtcggcac acgctgagac
     9721 cgcaccgcgc ggatggcgcg ccgtgcgccc ggtgaccccc accaccgggc gcacggcgcg
     9781 ccgtcgtgcg cggacgccga tcccgggcgg aggagagcgg aggggaggcg tgtcctgcgg
     9841 ggcggcggcg ttccgcgggc ccgcgccggc ccccgggcgg atcgtgacct ccaccccgat
     9901 gccggcgttc atacgactga cgcgcgtttc gcgtgggtct cccgtgccac gggtaggggc
     9961 tcgcgcggta gggctacgtt catcgaaagg catgacacgc atggcacagc cgttcgcact
    10021 cccggagttc tacgtgccgt acccggcacg cctcaacccc catgtggacg cggcccgcgt
    10081 gcacacccgg gagtgggccc gccacatggg aatgctggag ggatccggga tctgggacca
    10141 ggacgacctg gactcccacg actacgcgct gctgtgcgcg tacacccacc cggactgtga
    10201 cgcggaggcg ttgtcgctgg tcacggactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctggag acgttcaagc ggaccctgga ccgcgcgggc ggcaaggcgt acctggatcg
    10321 gctgccggcg ttcatgccga cggacccgtc ggcgccggtg ccggagccgg agaacccggt
    10381 cgaggcgggc ctcgtcgatc tgtgggcccg gacggtgccg gcgatgtcgt cggcgtggcg
    10441 ggagcggttc gcggtggcga ccgagaacct cctcaacgag tccctgtggg agctgtcgaa
    10501 catcgacgag gggcggatcg ccaaccccgt cgagtacatc gagatgcgcc gcaaggtggg
    10561 gggcgccccc tggtcggcgg ggctggtcga gtacgcggcg ggggccgagg tgccggcctc
    10621 cgtggcggag tcgcggcccc tgcgggtgct gcgggacgcc ttctccgacg ccgtgcacct
    10681 gcgcaacgac ctgttctcgt accagcgcga ggtggaggac gagggcgaga acagcaacgg
    10741 cgtgctggtg ctcgaacggt tcctcggctg ctcgacgcag gaggcggcgg acgccgtcaa
    10801 cgacctgctg acgtcgcggc tccagcagtt cgagcacacg gcgctcaccg aggtcgcccc
    10861 gctgtgcgcc gagaaggggc tcgacccgcg ggagacggcg gcggtgctgg cgtacgcgaa
    10921 ggggctccag gactggcagt ccggcggcca cgagtggcac atgcgctcca gccggtacat
    10981 gaacgagggg gccgtcggcg ccgacccggg cggcggcgcc ttcggcatgg cggccgcgtc
    11041 gatccggctg acgccgcgcg cggaggccgc gcggtggcgc ggcttctccc acgtgccctt
    11101 ccagcgcgtc ggaccgtccc tgctgccgca cgtcgagatg ccgttccagg tgacgcacaa
    11161 ccggcacctg gagggcgcgc ggggacggtg cgtggagtgg ggccgcgcca tgggattcct
    11221 gcgggagcag ccggggcagc cggggtcggg cgtctggaac gagcggaaga tcgccgggta
    11281 cgacctgccg ctgtgcgcgg ccgggctgca cccgacggcg agcgccgacg acctggacct
    11341 cgcctcgcac tggctggcct ggggcacgta cggcgacgac ctgtacccgg tggtgtacgg
    11401 caggaccagt gacctggcct cggcccgggc gcagaacgac cgtctgaagt ccctcatgcc
    11461 gctggacgcc gccgcgaccg acgtgccggc cccggcgaac gcgctggaac gggggctcgc
    11521 ggacctgtgg ccgcggacgg tcggtcccat ggcggagcgg gaccgggcgg cgttccgcga
    11581 cgccgtctgc gtcatgatcg acagctggga gtgggaactg gtcaaccagg cccatcaccg
    11641 gatcccggac ccggtcgact acatcgagat gcggcgggcc accttcggct ccgacatgac
    11701 gatcgcgctg tgccggatcg gccacggcaa ccgcgtgccg ccggaggtct acctcagcgg
    11761 cccggtgcgg tcgctggaga acgcggcgat cgacttcgcg acgctgctga acgacctcta
    11821 ctcgtaccag aaggagatcg agttcgaggg cgaggtccac aactgcgtgc tggtcgtgca
    11881 gcggttcttc gacgtcgacc acccgacggc ggtggcgatg accggggagc tgatgaactc
    11941 ccggatgcgg cagttccagc atgtcgccgc acacgagttc cccgtgctgt acgaggactt
    12001 cgggctggac cgggagacgc gcgcggtcct cgacgggtat gtgcgggagc tggagaactg
    12061 gatggccggc atccacacct ggcaccgcga ctgcaagcgg taccaggagg aggtcctgct
    12121 ccaggaccgg gccgaggccc tggcgggggc gccctccctg ggcgggccga cgggcctcgg
    12181 cacctctgcg gcccgcgtcg cggcgctgct cgtcccctag ccggggcggg ttccgggcgg
    12241 ccggccgcct acgggcggcg gggctgtttc cgggccgttc acgggcggct cggttctctg
    12301 ccggcggccg gccgtctacg ggggcagggc cctcttcggg ctgcgggccg tctacgggcg
    12361 gccggcccgg ttacggggtg gccggttgcc cttcggacgg ctgccgtctt cgggctgccg
    12421 ggccgtctac gggcggcggg cgccgcgaag ctgatccagt tcgcggcgct cgcgcttcgt
    12481 ggggcggccg gcgccccgct cgcggacggc ggcgagggcg acgtgctcac ggggcggtgg
    12541 ggccggggtg cggtcggtgt acgcctcggc cgccacgggg gcgcccaccc gcttggcgag
    12601 ggcccgccgg acctcgacga cgcgctcgcg gccggcgtgg aacacacgga cctcgtcgcc
    12661 cggcttgacc gtctgcgcgg gcttggcgcg gtcgccgttg acccggacgt ggccggcgcg
    12721 gcaggcggtg gccgcctgcg agcgggtctt ggtgaggcgt accgcccaga tccagctgtc
    12781 gacgcgcacg ccggcgttcg cctgggcctc gtccgtcact gccatggatt cggtcccccg
    12841 tcgggtcagc cctgctggaa gagttccgcg gggaggggct tgaggagcgc gtacaggtcg
    12901 tcggtgatcg ggcggtccca gctcgcgatg gtcacgagga cgttgtcgct gcggtcgaac
    12961 tgcacgcagg agatccggct ctcggtgagc ttcagtcggc gcacgatgag gaggttgtcg
    13021 ccctgcatca ccgggacgtc ctccgtctcg gcgacctcga cgtggtcgtc catgtccagg
    13081 gccgcgagga gctgggccac ctcgaagggg atctgcccgt tggcgatgtc ccgggccggg
    13141 gagccctccg ggaggttgcc gatgatcatc gcggggccgc ggccgccgaa gaggtcgtag
    13201 cggaggaaga cgccctggca gctgccgtcg ggggcgggca gcaggccggc gccgaggttc
    13261 ccgggccagt cgcccggatc catggccagg acgtcgaagt ccgggcccgc gggtgtggcg
    13321 gggctgcggc ggcggaggaa ggacatggag ccatggtacg tggccgggac cggcgcgcgg
    13381 cgggtggggc ggcggcgcgg gcggggcgcc gtaccgcccg gacggcctgt cgccgccggg
    13441 tggttcaccg gttcggggga cggcgtgcgg gccgggtggg ggccggcggt ggccggggag
    13501 ggcggccggt gcggcacgcg tgtcgtgccc caggtgagtg ggtggggtcg gggccgcggc
    13561 gggtcacctc ctcggggtcg gcggcctcgg gtaccgcgga agtggacccg ctgtcgccgc
    13621 cgacccctgc gggggcgacc caccacgccc cctcccgacc gccgtggagc gccggggcgt
    13681 gggtcgtata cggcttgatc aggtccgggt cgcggggcgt gggatgcgtc gggcttggtc
    13741 gggtccgggt cgcggggcgt gggatgcgtc gggcttggtc gggtccgggt cgcggggcgt
    13801 gggatgcgtc gggcttggtc gggtccgggg gcttgccgct gcggggggcg gcggggtagg
    13861 tggaggtgtg gcgaccgaac ggtcggttgc ccgggaggaa ggacggcaca tggtggagga
    13921 cctgcgcgac gccggggagc ggatgggccg tgacgagctc gccgcggtgc agcgggagcg
    13981 gctgcgcgcc accctgcggc acgcgtacga gaacgtgccg ttctaccggc gggcgttcga
    14041 cgcggcgggg gtgcggccgg aggagtgcgc gtcaccggcg gacctcgccc gcttcccgtt
    14101 caccaccaag gcggacctgc gggaccagta cccgttcggg atgttcgcgg tggagcggtc
    14161 gcgggtgcgg cgcctccacg cgtcgagcgg caccaccggg cagccgacgg tggtcggcta
    14221 caccgagcgg gacctcgacg tgtgggcgga cgtggtggcc cgctcgatcc gcgcggccgg
    14281 gggccgtccg gggcaggtgg tgcacgtggc gtacgggtac ggcctgttca ccggcgggct
    14341 gggcgcgcac ggcggagccg agcggctggg ctgcacggtg gttccggcgt ccggggggat
    14401 gacggcccgc caggtgcgtc tgatccagga cttccggccg gaagtgatca tggtgacgcc
    14461 gtcgtacatg ctgacgctgc tggacgagtt cgagcggcag ggcgtcgatc cgcgctcgac
    14521 gtcgctgaag gtcgggatct tcggggcgga accgtggacc gaggagatgc ggcgggagat
    14581 cgaggagcgg tgcgcgatcg acgcggtcga catatacggg ctgtccgagg tgatcgggcc
    14641 gggcgtcgcc caggagtgcg tggagacgaa ggacgggctg cacgtgtggg aggaccactt
    14701 ctaccccgag gtcgtcgacc cggtgacggg tgaggtgctg ccggacggcg agcggggcga
    14761 gctggtgttc acctccctca ccaaggaggc catgccactg gtgaggtacc ggacccgcga
    14821 cctgacacgg ctgctgccgg ggacggcgcg gccggcgttc cggcggatgg agaaggtcac
    14881 gggccgcagc gacgacatgg tgatcctgcg gggcgtgaac ctcttcccga cgcagatcga
    14941 ggaggtcgtc ctgcgcaccc ccgggctggc gccgcacttc cagctgcgac tgacgcgcga
    15001 gggccggctc gacgcgctga cggtgcgggt cgaggcccgc cccggcacgg cgccgccccg
    15061 gcgggccgag gccgcccgcg aggtcgaggc ggcggtgaag gagggcgtcg gagtgacggt
    15121 gacggtggac gtggtcgccc cggagacgtt ggagcgctcg gtggggaaga tcaagcggat
    15181 cgtggacctc cgtacccaag gctgatcgcg tatccgtccc agggaggatg acaccgggcc
    15241 gtcacggatg agtgcatgga ccaactgacc tcgtccgcag ttctgttggg aggcacggtg
    15301 ctcctccgca cccatctgag acgtctgctg ccggctgccg tcgcgttact ggcgaccgcc
    15361 gcgaccacgc ttccggccac cgcggccgga ccgcccgccg aggggaggaa cccctcggcg
    15421 ggcggcctgt cggccacgat ccgctacacc gagtacggca tcccgcacat cctggcccgg
    15481 gactacgccg ggctcggctt cggcacgggc tgggcgcagg ccgccgacca ggcgtgcgtc
    15541 ctcgccgacg ggttcgtcac cgtgcggggt gagcggtcgc ggtacttcgg gccggacgcc
    15601 gtaccggacg gatcgctgtc gtcggcccgc cgcaacctct ccagtgacct gtacttcacc
    15661 ggggtacggg aagcgcgcac cgtcgaacgg ctcctggcgc ggcccgcgcc ggccggtccg
    15721 agccggacgc aaaaggagct gatgcggggc tgggcggccg ggtacaacgc ctggctggcg
    15781 aagaaccggg tgaccgaccc ggcgtgcgcg ggcaagccgt gggtccgccc ggtgaccccg
    15841 ctggacgtcg cacggcggag ctacgcgctc gcggtgctcg gcggccaggg agccgccgtg
    15901 gaggccatca cggccgccgc cccgcccgcc gcgggcccgg ccgcgggccc ggcgcccgac
    15961 gcgcggcgcc tcgccgaggc ggcccgcggg atgttcgacg agcggaccgc gacgatgggc
    16021 tccaacgccg tcgcgttcgc cggcggcacc acggcgaacg gccggggcct gctgctgggc
    16081 aacccgcact acccctggca cggcgggcgg cggttctggc agtcgcagca gacgatcccg
    16141 ggcgagctga acgtccaggg cgcctccctg ctcggcgcgc cgctggtgca gatcggcttc
    16201 agcgacaagg tggcgtggag ccacaccgtg gcgaccggtc gcaccttcaa cctccaccag
    16261 ctgtccctcg accccgccga ccccacggcg tacgtggtgg acggccggtc ggagcgaatg
    16321 gtgcgccgca ccgtcacggt gcccgtcgcg agcggtgatc cggtgacgcg cacgcagtgg
    16381 tggacccggt acgggccggt cgtcacggcc ttcgccggcg acccgctgcc gtggacggcg
    16441 accaccgcgt acgcgctgca cgaccccaac gccgagaacc tccgcatggc cgacacctcg
    16501 ctcggcctgg ccaaggcccg ctccacgcgg gacgtcgagc gggcgctgcg ccgcacgcag
    16561 ggcctgccgt gggtcaacac cgtggcgtcc gaccggaacg gcggcacgct gttcgcgcag
    16621 gcccaggtgc tgccccggat caccgacgaa ctggccgaac gctgctcgac gccgctcggg
    16681 cgggccctct acccggcggc gggcatcgcc gtgctcgacg ggtcgcgcgg cgcatgcgcc
    16741 ctcggcaggg accgggacgc ggtccagccg ggcatcatgg gcccgtcccg ctggccggtg
    16801 ctgagggacg cggcgtacgc cgagaactcc aacgacagcg cctggctggc caacgcggac
    16861 cggccgttca cccggtacga gcgggtcttc ggcgacatcg ggacggagcg gtcgctgcgc
    16921 acgcgcggcg cgatcgagga cgtcgcggcg atggcggacc ggggcgggct gacggtggcc
    16981 gacctccagc gccagcagtt cgccaaccgg gtgccggccg ccgacctcac ggccgacgac
    17041 gtcgtacggg cgtgcccggc ggccctgccg gacgagcccg cggcgtgcgg ggccctcgcc
    17101 cgctgggacc gccgggtgga caccacgagc aggggcgcgc tgctcttcga ccggttctgg
    17161 ctgcgcctgc agcgggaggt cccggggccc gaccgttgga aggtgccgtt ctccgctgcc
    17221 gaccccgtgg gcacgccccg gtcgctgaac accgcggccc ccggcttcgc cacggcgctg
    17281 cggggcgcgg tcaccgaggt gcgggcggcg ggcatcccgt tcgacgcgcc cctcggcgag
    17341 caccagtacg tggtgcgcgg cggggagcgg atcccggtgc acggcggtac ggggacgggc
    17401 gtgtggaaca tgacggtgcc cgtgtgggac gccgcgcgcg gcgcctacac cgaggtgcag
    17461 cacggtacga gccacgtcca ggcggtgggc tgggacgaca gccgctgccc ggtggcgcgg
    17521 acgctgctgt cgtacgcgca gtcgtcggac cccggctcac cgcaccacgc cgaccagacg
    17581 cggctgtact cccaggagcg gtgggtgacc gcgcggttct gcgagcggga catcctcagc
    17641 gaccccgcac tgcgggtggt gcgggtggcg cagtgaccct caggggctga acgacaggaa
    17701 gacgaaggcg gcgaacagca ccaggtggac gccgctctgc aggagtgtgg cgcgtccggg
    17761 caccacggtc agggcgctca ccaccgcggt gagcgccagc agcaccaggt ggacggggcc
    17821 cagccccagc accaggggcc cggacagcca cagggaggcg agcgcgatca ccggcacggt
    17881 caggccgatg ctggcgatcg ccgagccgta ggcgaggttc aggctggtct ggacgcgttc
    17941 cccgcgggcc gcccgcacgg ccgccagggt ctccggcagc agcaccatga gggcgatgac
    18001 gacgccgacg acggccgtgg gcaggccggc cgtctccacc ccggactcga tcgtcggtga
    18061 gacgaccttg gcgaggccga cgacggccac cagggccacc gccagcagcc cgaggctcca
    18121 ccaggtggcg gcgcgggtgg gcggcacggc gtgggcgacc gcgtcgagcg gctccccggt
    18181 gcgggcgacc ggcaggaagt agtcacggtg ccggaccgtc tgcacggtga cgaagagccc
    18241 gtacaggcag agcgaggcca cggcggcgaa ggcgagctgc gccccggtga actccgggcc
    18301 gcggctgccg gtggtgaagg tggggagcac gagcgtcgtg gtggccaggg tggtcaccgt
    18361 ggcgagggcc ccgccggacc cctcggcgtt gaagacggcc acgcggcggc cccggagggt
    18421 cgccacgagc agggacgcgc cgacgatgcc gttgcaggtg atcatcacgg cggcgaagac
    18481 ggtgtcgcgg gcgtacgtgg ccgcgctgtc gccgcccgag gccatcagca tgacgatgag
    18541 gcccacctcg atgaccgtca cggcgaccgc gaggacgagg gagccgaacg gttcgccgac
    18601 ccggtgcgcg accacctcgg cgtggtggac ggcggacagc acggccccgg cgaggcagag
    18661 cccgacgacc gcgacgagca cgcccggcag gtcccggccc cagcacagcg cgaggacgag
    18721 caccgccacg gccgggaccc aggtggtccg ttcccgccag gggcgcggcg tggcggcccc
    18781 gccgtcggcg ccgccggggc cgccccggtc cgcgtccgtc tgcttgccca tgcggccacg
    18841 ctgccagagc ggtgcgcggg ccgcacccgg tcggcgcggc ggctgctccg gtcggcggcg
    18901 acgtccgcgg cgccggttcc tgcgggcgcc gacggtggta ccggcggggc gccgacggcg
    18961 ggcgtccggt gggccccggg cgggtgcggc ggcgaggtcg tcccgcccgc ctccttgacg
    19021 ggtgggtgcg gcggtaagaa cgtttcaccc ggtacgcgcg agggtcgagg tttccttcag
    19081 gcggggaggg cggggcatgg ggcgggagcc ggcgggcggg cacgggatcg gacggcgggc
    19141 gttcggcggc ggggttctgg cactgggagg tgcgctggtg atcggtccgg ttccgggggt
    19201 ccggggggcg cagccggagc ggcccggaag cggcccgcac ggggctgggc acggggcggg
    19261 gccggtgctg cggcgcggga cggccgagcg ggccggactg ctgccggacc acctcgaccg
    19321 gctcgtcgac gacgcggagc ggttcctcgg cccctccccc acgcacccct ggtacgcggg
    19381 cgcggtggtc ctcgccgggc gcggcaccac cgtggccctg caccgggcgg tcgggtacgc
    19441 gctgcggtac gcggcgtacg acgagacgac ggaccggggc gtggagctgc cacccgaacg
    19501 gcgcatcccc atgcacgagg acaccgtgtt cgacctggcg tccctcacca agctcttcac
    19561 ctcgctcctc gtcgtgcagc tgctggagcg cggcgaactg gagctggagg gccgggtcgc
    19621 ggagcggctg ccggagttcg ggggcggcgg aaagggcggc gtgacggtcc gccagctgct
    19681 gacgcacacg tcggggttgc gggcctggct gccgctgtac cgggaaccga cccgcgaggg
    19741 caggctgcgg atgctgtggg aggagcggcc gaccgacgcc ccgggcacgc tgtaccgcta
    19801 ctcggacctc aatctgatcg ccctgcagct gctgctggag gaggtgaccg gccggccgtt
    19861 ggacgtactg ctgcgggagc ggatcaccgg gccgctcggc atgcgccgca cccggttcgc
    19921 cccgccggcc tcctggcgtc cgcgcatcgc cgcgaccgag gacgcccggc cgccgtggtc
    19981 ggggctcgac cgggggctgg tgtggggcga ggtgcacgac gagaacgccc acgccttcgg
    20041 cggggtcgcc gggcacgcgg gggtgttctc ccgcgcgtgg gacctggccg tcctcgcccg
    20101 cacgctgctg aacggcgggg cgtacggccg cgcccggatc ctgcggccgg actccgtcga
    20161 gctgctgttc accgacttca acaccgcgtt ccccggggac gagcacgggc tcggcttcga
    20221 gctgtaccag cactggtaca tgggggcgat ggcgacgccc cgctcggcgg ggcacaccgg
    20281 gttcaccggg acgagcctgg tcctggaccc gacgaccgac gcgttcctgg tgctgctggg
    20341 caactcggtg cacccggtgc ggacgtggcg ctccgggtcg gcgccgcggg tcgcggtggc
    20401 cgaccggctg gcgcgggcgg taccggtgcg ggcggcacac ggccgtaccg cctggttctc
    20461 cggcatggcg tccgcgacga cggcgacgct caccctgccc gccgtgcggc cggccacggc
    20521 gcgggcgagg ctgcggtgcg ccctgtggtg ggacaccgaa cccggcacgg acgccctggt
    20581 gctggaggcg tcggcgacgg acgcttcgga gggggcggtg tggcggccgg ttccgttcac
    20641 caccgtgccg ccgggcgggg agcccgcggc gcacccgggc ggcgcggtgt cgggctggtc
    20701 ggggcgggtg tggcaccggg cggaggcgga cctgtcggcc tggtccggct ccggcccggt
    20761 gcggctgcgc tggcggtaca cgaccgacgg ccggtacgtc gggcggggcg cgtacgtcga
    20821 ccggctgcgc gtcctggacg gggacgacgc gctgttcgac gaggcccggc cggcggacgc
    20881 cgcgcgcgtc gaggcacggg gctgggtgcc gtcggccgac tgaccggggt cgcggtcgcc
    20941 gggcggcccc gtcgcgccga cggagaggcg gcggcccggc cgacggcccg cgcggtgagc
    21001 gcgcggatgc gcgggccggg acgggcgggg agactggagg ccagggggtc actcggcgag
    21061 aggacgaccc atggccatga tggacaagct caagagcatg ctcaaggggc acgaggggca
    21121 gagcagcagg ggcgtcgaca aggtgggcga catggtcggc cgccgcaccc gcggcaagca
    21181 cagccgccac gtcggcaccg cccaggaacg gctcaaggac cagctgggcc ggcgccgggg
    21241 cgggcacggc ggcgagccgc cgcggccctg acccacctcg cgcaccacgt ccgggtcccc
    21301 ggtccgccgt cacggacgga ccggggacct ccgcgcgtgt gcggtgcccg cgccacccgg
    21361 tcgagcgccc cggcgtgcgg tgcgcccgcg gctgatggag agtcgtgccg agtccccaca
    21421 ctcgaaggag agaaacatgc ttcggcgcat ctcgatcgct ctggccggtc tgctcgctgt
    21481 cggcttcctc accgcctccc ccgccgccgc cgactcggac ggcgtcaagg gctgctgggt
    21541 gtccggcggc cacgtctcgg cgggcgacgt ccacgtcgcc ggattcgaag gcacctgctg
    21601 gcgcgtcggc tgacacggct gtcgcacggt cgcgggtggg cgccccacgg ggtgcccacc
    21661 cgaaccgttt ccccgcacgc gccgcgcggt cgacgccgtg ccgtcggccc agggggcgcg
    21721 gacggtgtcc ctcagcccgg ggtgcgccgg cggtgggcgg ccgccacccg ccggtgcagc
    21781 tccaccgcct cggtgtgccg gcccagctgc tccaggcact gggcctcgtc gttccggctg
    21841 gcgagcgtgt ccgggtggtc cggcccgagc acccgctcgc gggccccgga cacgagccgg
    21901 tagccggtga gcgcctcggc ccagcggccc aaccagccca ggcacacggc gacctcccgg
    21961 ccgctgacca gcgtgtccgg gtggtcgggg cccaggacgc gggcgcgggt cgccgcgacg
    22021 tcgcgggcct cgcgcagggc ctcctcccag cggccgagcc ggccgaggtt gacgcccagg
    22081 ccgtgccggg cgcgcagcgt ctcggggtgc tccggtccct gcacccggct gcgggcggcc
    22141 gtcaggtccc ggtacagctc cagcgcctcg tggccccggt ccaggcggcc gagggcgatg
    22201 ccgacctcgt accgggcggc
//
