LOCUS       NZ_CP102135            23252 bp    DNA     circular CON 22-AUG-2024
DEFINITION  Streptococcus suis strain M106471_S40 chromosome, complete genome.
ACCESSION   NZ_CP102135
VERSION     NZ_CP102135.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus suis
  ORGANISM  Streptococcus suis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2226093)
  AUTHORS   Fredriksen,S.
  TITLE     Hybrid assemblies of Streptococcus suis isolates from transcriptomic
            study
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2226093)
  AUTHORS   Fredriksen,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUL-2022) Host-Microbe Interactomics, Wageningen
            University & Research, De Elst 1, Wageningen 6708 WD, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 351x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024582935.1-RS_2024_08_22
            Annotation Date                   :: 08/22/2024 05:41:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,250
            CDSs (total)                      :: 2,178
            Genes (coding)                    :: 2,116
            CDSs (with protein)               :: 2,116
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 62
            CDSs (without protein)            :: 62
            Pseudo Genes (ambiguous residues) :: 0 of 62
            Pseudo Genes (frameshifted)       :: 26 of 62
            Pseudo Genes (incomplete)         :: 37 of 62
            Pseudo Genes (internal stop)      :: 14 of 62
            Pseudo Genes (multiple problems)  :: 12 of 62
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:58:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 261644
            Orig. end                         :: 284896
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP102135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23252
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23252
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23252
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13252](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13252
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            229..816
                     /locus_tag="NQZ98_RS01455"
                     /old_locus_tag="NQZ98_01455"
     CDS             229..816
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646370.1"
                     /locus_tag="NQZ98_RS01455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01455"
                     /product="DUF4352 domain-containing protein"
                     /protein_id="WP_024389724.1"
                     /transl_table=11
                     /translation="MQTKDFVVENGQMYYKKKPLHKQPLFWTTIAGAVLSFILGVTCFI
                     FMIGLSAANFDNWDTGSDGYIDETVEYTEYQVGDSVDFSDGLHVTVTSMGKDDSVELVD
                     SYYSTAYVVEMEVENSTAEELYFDEYYFSLMDPVSQIPFTLDLRTYDVNLVEKLKPGEK
                     VQVKLIYGIDNETNFGFTYEDAMWTELVAEGI"
     gene            complement(1051..2397)
                     /gene="gdhA"
                     /locus_tag="NQZ98_RS01460"
                     /old_locus_tag="NQZ98_01460"
     CDS             complement(1051..2397)
                     /EC_number="1.4.1.4"
                     /GO_function="GO:0016639 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gdhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999806.1"
                     /locus_tag="NQZ98_RS01460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01460"
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="WP_014636785.1"
                     /transl_table=11
                     /translation="MSNAKAYIQASFEAVKARNPHETEFLQAVEELFSTLEPVFEAHPE
                     YIEENILARIVEPERIISFRVPWTDKDGNVQVNRGYRVQFNSAVGPYKGGLRFHPTVNQ
                     SILKFLGFEQIFKNVLTGLPIGGGKGGSDFDPKGKTDAEIMRFCQSFMTELQKHIGPSL
                     DVPAGDIGVGGREIGYMYGQYKRLRQFDAGVLTGKPLGFGGSLIRPEATGYGLVYFTDN
                     MLAANGKSFKDQTVLISGSGNVAQYAVQKATELGAKVISVSDSNGYIIDETGIDFDLLV
                     DIKEKRRARLTEYAAEKATAKYFEGSVWNYDGKADIALPCATQNEINGEQAAALVKNGV
                     YCVAEGANMPSDLDAIKVYKENGVLYGLAKAANAGGVAVSALEMSQNSLRLSWTREEVD
                     GRLKDIMANIFNTAKETAEKYDLGTDYLAGANIAAFEQIADSMIAQGLV"
     misc_feature    complement(2428..2442)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.7"
                     /tool="antismash"
     misc_feature    complement(2452..2465)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.78"
                     /tool="antismash"
     misc_feature    complement(2530..2542)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            2620..3558
                     /locus_tag="NQZ98_RS01465"
                     /old_locus_tag="NQZ98_01465"
     CDS             2620..3558
                     /EC_number="1.3.98.1"
                     /GO_function="GO:0004152 - dihydroorotate dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999807.1"
                     /locus_tag="NQZ98_RS01465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01465"
                     /product="dihydroorotate oxidase"
                     /protein_id="WP_015646373.1"
                     /transl_table=11
                     /translation="MVSTATTLGGFTFDNCLMNAAGVWCMTKEELDAVKNSKAGTFVTK
                     TATLDYRAGNPEPRYQNVPLGSINSMGLPNQGLAYYLDYLLELQEMEPERTFVLSLVGM
                     SPDETHEILRTVEASDFKGLTELNLSCPNVPGKPQIAYDFETTETILQEVFTYFTKPLG
                     IKLPPYFDIVHFDQAAAIFNQFPLKFVNCVNSIGNGLYIKDESVVIKPKNGFGGIGGEY
                     IKPTALANVHAFYQRLKPEIQIVGTGGVLTGRDAFEHILCGASMVQVGTTLQKEGVAAF
                     ERITAELQAIMAEKGYETIEDFRGKLQHLDD"
     misc_feature    3851..3864
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.26"
                     /tool="antismash"
     gene            3891..5123
                     /locus_tag="NQZ98_RS01470"
                     /old_locus_tag="NQZ98_01470"
     CDS             3891..5123
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775487.1"
                     /locus_tag="NQZ98_RS01470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01470"
                     /product="CapA family protein"
                     /protein_id="WP_257116647.1"
                     /transl_table=11
                     /translation="MEKRANYIRRKRYASYRTKMHLFFICGLATIILAIIIVSERLVPR
                     LNQASESMRSDNSVRIMAHGDLLYHLPILRGAEQPDGSYDFSENFTYVKPWIEQADFAI
                     ADFEGTISPDVELAGYPLFNAPAIVADNIHDAGYDLVDLAHNHILDSHLSGLISTVNTF
                     RDAGVDTVGVYAEGNRATAPLYIREVNGIRIAVLAYAYGFNGMEALLSQEEYDAYLSDF
                     DKEKMRAEIERAEKEADITIVMPQTGVEYQLEPTEEQTSLYHQMIDWGADIVLGGHPHV
                     VEPAEIIEKDGQRKLIIYSMGNFLSNQRIESMDDTPNSQWTERGVLMDIRIQKENGQTS
                     IRTAQAHPTWVNRISQGTYSQDGYERFSYQTYVLEDWVAGGRYYGQLDLDTQARVDTAY
                     QEMKDFVNLVW"
     CDS             5291..5368
                     /gene="allorf_0266935_0267012"
                     /locus_tag="allorf_0266935_0267012"
                     /protein_id="allorf_0266935_0267012"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIRESLNCMLPKTDHIECVALLVKV"
     CDS_motif       5291..5317
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIRESLNCM"
                     /locus_tag="allorf_0266935_0267012_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5318..5368
                     /prepeptide="core"
                     /locus_tag="allorf_0266935_0267012_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="1760.1"
                     /monoisotopic_mass="1759.0"
                     /core_sequence="LPKTDHIECVALLVKV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIRESLNCM"
                     /leader_location="[5290:5317](+)"
     gene            complement(<5491..5724)
                     /locus_tag="NQZ98_RS01475"
                     /old_locus_tag="NQZ98_01475"
                     /pseudo=""
     CDS             complement(<5491..5724)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611996.1"
                     /locus_tag="NQZ98_RS01475"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01475"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSRRIRRHFTDDFKQQIVELHKAGRKRSEHIKEYNLTPSTFDKWV
                     RQAKTTGSFKSVDILTDEQHELIALRKRNKELK"
     gene            complement(5825..6691)
                     /locus_tag="NQZ98_RS01480"
                     /old_locus_tag="NQZ98_01480"
     CDS             complement(5825..6691)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /locus_tag="NQZ98_RS01480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01480"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_024378455.1"
                     /transl_table=11
                     /translation="MNNILGERLKILRKQKNLSQKELAEGICEPSQLSKFERGLVNPSS
                     KLLNKLAKRLEISMEYFFDEDIVIHSNLESFKSIATKLLEDRNYKELEYLTILERNNNS
                     VLSNDDNCYLEWIDAILLFYNYHQKEEAISQLETLLYKVNDHEITYLNILNTLSNFYSL
                     TNQIIKYETNYKKLVKEYQNKDLSVSTYLFGYIKIQYNYSYHLWKQGEPLSAIKIAMQT
                     IELCKLHHTSYQLAPLLTIVANAGEKFLPKDKRKEYYTDAKNLCKIYDNDLMYLQLEEA
                     LNKNFAD"
     misc_feature    6777..6790
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.0"
                     /tool="antismash"
     gene            7177..8112
                     /locus_tag="NQZ98_RS01485"
                     /old_locus_tag="NQZ98_01485"
     CDS             7177..8112
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245733.1"
                     /locus_tag="NQZ98_RS01485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01485"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_029188090.1"
                     /transl_table=11
                     /translation="MQHQVIQTSNLSKSYDGRIILEKINFTLNQGEIYGLLGRNGAGKT
                     TFIKAILGLIEMDSGEVRILSEKLSGEFSKDLLYRVGVVLDSAAFYPNLTGKENLSIFA
                     KLRGISLKQVDQALQVVGLYGEDRKLFKQYSLGMKQRLAIANAIMHHPQILILDEPTNG
                     LDPIGILEMRRYLKELSTNQGISILISSHIISELEKLVDRVGILHNAHLIAEKSMKGLV
                     SDTEQNTVHLTVSDAHQAKEVLCKFKLKGVVSILSDVDLELQGGPSDFDIAAVSAILKE
                     NGIVLKEYFYRNHESLEDYFERITGGEGIA"
     gene            8105..8845
                     /locus_tag="NQZ98_RS01490"
                     /old_locus_tag="NQZ98_01490"
     CDS             8105..8845
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886369.1"
                     /locus_tag="NQZ98_RS01490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01490"
                     /product="ABC transporter permease"
                     /protein_id="WP_024378456.1"
                     /transl_table=11
                     /translation="MLELVKIEFLKQKHQKLNLVVYGVIALYLALIFYYVNDARGLFDS
                     FPFVYKFSLSYLNFLILPLYCVSYTIQAFGVEYRYNIINNLQLASANMLKTFWAKVLYI
                     EINALLIMMFTYVSVSLFALLSRFSSTVTLLLLLRFLYLCISSGLLIPVGVFPLVAFVM
                     IKGKGKDIIGNLVGVIYVLVSFFLARTSPNISPITSATSLIWEGNSEGVVLQQPASVSS
                     IVLGLSLFVLSFLSIKFWLRKAEN"
     gene            8852..9574
                     /locus_tag="NQZ98_RS01495"
                     /old_locus_tag="NQZ98_01495"
     CDS             8852..9574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000928810.1"
                     /locus_tag="NQZ98_RS01495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01495"
                     /product="ABC transporter permease"
                     /protein_id="WP_228377562.1"
                     /transl_table=11
                     /translation="MLELSKLRRRKFLYSLPLVVIFLFLLEFVMGNQLYQGHRYGSVNG
                     WYLENGFFFLNYYFLLPFSSMIVVDLIRIEQDSETIANLRLIPVDLKRLIQSKFILTLL
                     MNLLLSELIFLAMLVLEMIDGELVFSNITLLSWVIGYGVVAFAYTLFANLIVLFLGKCR
                     RQLILAVPFAFLLSFAGLFTLSTAFGQYYLVNLPLLIMKEFTLLTVFVYAIWFLVLLSC
                     VCYFLADRGMIKIIFAYK"
     gene            9704..9919
                     /locus_tag="NQZ98_RS01500"
                     /old_locus_tag="NQZ98_01500"
     CDS             9704..9919
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="NQZ98_RS01500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01500"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_171997344.1"
                     /transl_table=11
                     /translation="MSDWKKPIYESLSTEGNPAGDILRELSESEMDQAMAGGTARSYCG
                     CYSGEHSCGRGCTITTECPFLTFICC"
     CDS_motif       9704..9817
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSDWKKPIYESLSTEGNPAGDILRELSESEMDQAMAGG"
                     /locus_tag="NQZ98_RS01500_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9818..9919
                     /prepeptide="core"
                     /locus_tag="NQZ98_RS01500_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.20"
                     /molecular_weight="3426.9"
                     /monoisotopic_mass="3424.4"
                     /core_sequence="TARSYCGCYSGEHSCGRGCTITTECPFLTFICC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDWKKPIYESLSTEGNPAGDILRELSESEMDQAMAGG"
                     /leader_location="[9703:9817](+)"
                     /alternative_weights="3444.9"
     gene            10001..13252
                     /locus_tag="NQZ98_RS01505"
                     /old_locus_tag="NQZ98_01505"
     CDS             10001..13252
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001080431.1"
                     /locus_tag="NQZ98_RS01505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01505"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_171997343.1"
                     /sec_met_domain="DUF4135 (E-value: 4e-106, bitscore: 352.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.4e-66, bitscore:
                     219.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNREINITEFKDASYFSERRVASTDVNYCLKSRKRKEYWDKFIGE
                     GAEEFWEYLKEKNGFSNQDLNIFLEENEYDVEEIDSFLYMNKFIKFYFENNDYPLPDFY
                     IIDSKGKRKPIFSKFVIPFLKFGAYNLEGDLNSKKLKVTREVLNSLLVSLFQQILNISY
                     RTLILELQVLKEQKMLKGKTGEKRFEYFSEIYLSDNFWDILKEYPVMFRLIIENVQNWV
                     INNVEFLKHLEKDKSLLHKYFDINEELTKIESGISDFHNHGKSVYILWFGTNKLVYKPR
                     DLTLDVKFQKLLSWYNLRFNKNLYVTDILDRGNYGWVEYVEHLPCTNELDFIQFYTHLG
                     YLLFLLFAMRGNDIHFENIIASGNRPVLVDIETLFHNTIEYREKYETADKLIFSLLEKS
                     VKRVGILPNIVWGKDGNSGVDISGLSSSAGEVIPIERASIMHSMTDDMKIGYEQSVLQD
                     KENQPFILSNEDVDLNLYKNYISAGFKEAYEIISKDSSSVEEFMIEIEKFSDTYSRQIM
                     RPTQFYSNLIQTSYHPSFLRSGLDREMLFSKVWKIVFEDKKVQRIASSEFESLLLGDIP
                     LFQTKISERFLYSEFMEYRNFFNISGRELAVQQIKNFCSKDMEFQLNLIETALNYDPSY
                     NLVQDSFVSRTSSIKVIHSLNQREIQETKNRIVPLAEKIANYLSGISYSGTSGDVGWVD
                     MNILGEKTNDWNMVPIGCDLYNGISGIMIFYLFLYLETKNEEYLIYLKKCYQSLKYYLD
                     SRKQFVTHSHILFGGFSGETPIIYVLLLLKTRIAEHFDPEELDVYIYDIIDDLKQGYRQ
                     DENYDVLVGSAGAIVHLLNVFEVTKDEELLELAYSLFCHLEKNSLRIVVDGRDGKAWKG
                     TMASNPLAGFAHGVSGIVWSLSKLSRYFQKDKRLKDIIEQGIIFENSLFDTEKMNWSDY
                     RETDSGIKYKDIVENIPVSWCHGAPGILLSRLELYKNNTLNVEFREKMKSDMDVAIDTT
                     IKYGFGKSHCLCHGDLGNLSILLYVAEKTSSDYLYSVVYSYLNTILDDLESENWKCGLP
                     YKNSPSLMSGIAGIGLGLLTLNNPSIPSVINLEIW"
     gene            13259..15382
                     /locus_tag="NQZ98_RS01510"
                     /old_locus_tag="NQZ98_01510"
     CDS             13259..15382
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756060.1"
                     /locus_tag="NQZ98_RS01510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01510"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_171997342.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.6e-32, bitscore:
                     108.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVKFIQQLSNTSCGLACLAMILDYYGYETNLYELCCDFENSRD
                     GLSIKDIKNIASNFGMDVKAIEVLNFKKFFSEKFVEPYIALTSNAHYIVVEKHDEHNVI
                     FIDPEKGRMTENISEFMNNASGIVIFCSPNEKFTPKKKYNSFFKILKIGEIDIKRLCYI
                     SLISIVVQSLTLLLPLVTRYIIDDVISRREMYRSGMIISIFSLIIFYALFSLIRTKLMI
                     TVEKKYIFTLKDTIVSKIFTLPMKFFDSRSSGEIVSRINHLDSLEKIISSGISSLLIDL
                     STVVIAFIAMALMSVYFTLIIMFFAMFLFVVLYFLLKKLEEKNSNFIRSKELTQGYLME
                     IFSNLLFLKVSARGDVSYSKWKEMFSNELRFDVERENYLNIFQTFISVYRLLPNVLILI
                     LGSIEVQQHTMSLGSLMSFLSLVSLVLSPIALIVQNCFQFQFCFTILDRVFDIIYTPEE
                     KNKFSISKMPALKKITFSGLNFSYGGGSKVIDDIALTIRRGERIAIVGKTGCGKTTLIK
                     LLLRLYEVEEGTVLYNDNDINLFDLNSYRKNFGVVLQNDVMFNDTILSNIDLTHSHSME
                     DIITAANLAKLDTEINNMPMGYYTSVGDNGNNLSGGQRQRLAIARAILQNPEIIIFDEG
                     TGQLDSITEKQIMDNLKYRGITQIFITHRLSNAKEYDSIVVMDNGKIIDIGKHDELCSK
                     EGMYKRLFEASHS"
     gene            complement(16225..16629)
                     /locus_tag="NQZ98_RS01515"
                     /old_locus_tag="NQZ98_01515"
     CDS             complement(16225..16629)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012920.5"
                     /locus_tag="NQZ98_RS01515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01515"
                     /product="S24 family peptidase"
                     /protein_id="WP_257116648.1"
                     /transl_table=11
                     /translation="MEQKVLLLFSVRVLDNVALSAGHSNGIWDEYETKEVFTDKEYLYD
                     VATWIEGQSMEPVYQDCEVALIREGGFDYDGAVYAIAWNEQVYIKKVYLEEDGYRLVSM
                     NDSYPDKFALAVDNPRIIGKIVGNFMPIEQ"
     misc_feature    16685..16698
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.54"
                     /tool="antismash"
     gene            16814..17277
                     /gene="tnpA"
                     /locus_tag="NQZ98_RS01520"
                     /old_locus_tag="NQZ98_01520"
                     /pseudo=""
     CDS             16814..17277
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene="tnpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775157.1"
                     /locus_tag="NQZ98_RS01520"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01520"
                     /product="IS200/IS605-like element ISSsu4 family
                     transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVQKAHSLSHTKWLCSTTLSSHLSIDEKSSIINIEVVWEKYSDVC
                     VLIKVLKLSKVI"
     gene            complement(17527..17727)
                     /locus_tag="NQZ98_RS01525"
                     /old_locus_tag="NQZ98_01525"
     CDS             complement(17527..17727)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418929.1"
                     /locus_tag="NQZ98_RS01525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01525"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_171997341.1"
                     /transl_table=11
                     /translation="MRFSYNGLWKLLIDKGWTKSELRQKAGISSSTIAKLGKGENVTTD
                     VLLRICIALDCDIEDIVEIIP"
     CDS_motif       complement(17644..17727)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRFSYNGLWKLLIDKGWTKSELRQKAGI"
                     /locus_tag="NQZ98_RS01525_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17527..17643)
                     /prepeptide="core"
                     /locus_tag="NQZ98_RS01525_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="3950.5"
                     /monoisotopic_mass="3948.1"
                     /core_sequence="SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEIIP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRFSYNGLWKLLIDKGWTKSELRQKAGI"
                     /leader_location="[17643:17727](-)"
                     /alternative_weights="3968.6"
                     /alternative_weights="3986.6"
                     /alternative_weights="4004.6"
                     /alternative_weights="4022.6"
     gene            complement(17717..19375)
                     /locus_tag="NQZ98_RS01530"
                     /old_locus_tag="NQZ98_01530"
     CDS             complement(17717..19375)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904398.1"
                     /locus_tag="NQZ98_RS01530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01530"
                     /product="DUF2326 domain-containing protein"
                     /protein_id="WP_171997340.1"
                     /transl_table=11
                     /translation="MLIEMWSPVFKKNGQTRKPVRFHPGLNVIMGMDLADNSIGKSSSL
                     LVIDFIFGGNSYQKSIAVKKLGDHPIYFCFQFEKKFYFSRDTATPDIITYCNDDYSPTG
                     ETMPLENFLNKLKKRYHLDSPELSFRLAMSGFFRIAGKNNQNTDFPLQVYSSQKSSESI
                     TTLIQLFNLYDNIARYKERLKDKSDQLTTFRNARKYAFISNLVGGKKQFEANVSEIKRL
                     EYDLSHLQDTHQDKIDSDDIEKNQQKIQLRNTKLELENSLRDKQRRLKLLDISIEFGLY
                     PTESDLTELQRYFPDTNLKKLYEVEAYHKKLATILDSEFSTERETLSLEIEGLESQLTV
                     LNRELQELGSIPNLSTEFLENYSKLTAMINALKEQNGAYLKESALSKEKSEADSDLKRS
                     TEDILIELEGKINTKMREFNNVLYPDIRKAPQINLKAHNSYSFYTPDDDGTGTKFKGMI
                     LFDLTMLYLTNLPALAHDSLLLSNISYQATEALLKLYDRSKSLNKQVFLAFDKASSYSP
                     EANQLLSENTVLRLSSNGNELYGISWNKGENSDEI"
     gene            complement(19366..19590)
                     /locus_tag="NQZ98_RS01535"
                     /old_locus_tag="NQZ98_01535"
     CDS             complement(19366..19590)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176804.1"
                     /locus_tag="NQZ98_RS01535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01535"
                     /product="ABC-three component system middle component 7"
                     /protein_id="WP_032511731.1"
                     /transl_table=11
                     /translation="MQLPNKLYSYQKSTLAYLPKVLNEIKSGNSNVKDIFHAISEELDD
                     PTDFLSIMDCLYALNAIEMSNEGEVNLCL"
     CDS_motif       complement(19477..19590)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQLPNKLYSYQKSTLAYLPKVLNEIKSGNSNVKDIFHA"
                     /locus_tag="NQZ98_RS01535_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19366..19476)
                     /prepeptide="core"
                     /locus_tag="NQZ98_RS01535_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="3949.4"
                     /monoisotopic_mass="3946.8"
                     /core_sequence="ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQLPNKLYSYQKSTLAYLPKVLNEIKSGNSNVKDIFHA"
                     /leader_location="[19476:19590](-)"
                     /alternative_weights="3967.4"
                     /alternative_weights="3985.4"
     gene            complement(19590..20708)
                     /locus_tag="NQZ98_RS01540"
                     /old_locus_tag="NQZ98_01540"
     CDS             complement(19590..20708)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000347290.1"
                     /locus_tag="NQZ98_RS01540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01540"
                     /product="ABC-three component system protein"
                     /protein_id="WP_171997339.1"
                     /transl_table=11
                     /translation="MDFPTYFRILKKYLGDGATIPEFFRELIEMITEDDAEEIISASGI
                     TSEKTDNTLVSYAKRSFSKKMANQLLYRVNSANMTESIESRPDETIQLLAEEFNSYYPD
                     ITVENASQKIPEIFVDFIREKAGMGISTTAQKATFVNQSNQLKKQYGQFLLTEANNCCA
                     FPGCDRPLILTSGNLATENYEVSVIEKDKDAEPLNLIALCPDCFLTYQADNRKKTVIAL
                     KNVKKILVSTHNSQRPISDLKLDNGIVAVLTGLNKLKFDEYDISYDPKQLTDKISPENN
                     RTLYQMVKNQVIDNYLTIQKIIVNLDKQGKIDYEEIQYQMRSMYKKLKATKHDNLAIFN
                     TISEKLHKATLQDIYFCQMIVSYFIQKCEVLE"
     gene            21141..21737
                     /locus_tag="NQZ98_RS01545"
                     /old_locus_tag="NQZ98_01545"
     CDS             21141..21737
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648121.1"
                     /locus_tag="NQZ98_RS01545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01545"
                     /product="hypothetical protein"
                     /protein_id="WP_032511732.1"
                     /transl_table=11
                     /translation="MTNKDNIYNECQKQECSLEVGLLEGQVLAPMLVENQQVIEDMHLK
                     RETLRSWRPAKQLNVYVLVAFIPVYPEEYTQTERIYKDAVENFLSEFRTRKSKNIKEII
                     SYESWIDTDESSFHSSTKELEEFMFAEMLQVLLEKVRQADKDLYDITLGLLAKEFDESI
                     EDVFARIGVKRSTGFYRLPKARALVAALLKELNPK"
     gene            21978..22487
                     /locus_tag="NQZ98_RS01550"
                     /old_locus_tag="NQZ98_01550"
     CDS             21978..22487
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000544985.1"
                     /locus_tag="NQZ98_RS01550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NQZ98_01550"
                     /product="type III toxin-antitoxin system ToxN/AbiQ family
                     toxin"
                     /protein_id="WP_032511733.1"
                     /transl_table=11
                     /translation="MHEMKFYQIDTNYLNILRQIDGRVPHNKEFIGRKGKSRPYIGVML
                     SIDNVDYFVPLSSKKKRSSFVVMPIYDDNNEQIATLMLNNMLPVPPKHRKLLNMEGVRT
                     TDPKYFDLLMNELNFLRPKREAIKSRCSIIRSVKVDGKNKPQINERTKEFCLELIELEK
                     AYKENE"
     misc_feature    complement(21995..22009)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.54"
                     /tool="antismash"
     misc_feature    22002..22017
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 23.75"
                     /tool="antismash"
     misc_feature    22850..22866
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.24"
                     /tool="antismash"
ORIGIN
        1 tcaatttgag agagatcagc aattttgacc agattacagg tgtgactgta ttaggtcccc
       61 aaaacgctat ttcgggacag tttgtatttc gtgttaatct tttcgtagcc aacggtcaac
      121 agaacaagat ctatcatcaa ttctttggtt tttatcaaga tgctctgcgt caagcaggaa
      181 tagatttacc ttcaagtggg ccaactgttt taaaataagg agtttattat gcaaacaaaa
      241 gattttgtcg ttgaaaatgg gcagatgtat tataagaaga aacccttgca caaacagcct
      301 ctcttttgga caaccattgc tggtgccgtt ctctccttca tcctaggagt aacctgtttt
      361 atttttatga tcggcctaag tgcagcaaat tttgataatt gggatacagg tagtgacgga
      421 tacattgatg agactgtgga atacacggag tatcaagttg gtgactcagt tgatttttct
      481 gatggccttc atgtgacagt aacgtctatg ggcaaagacg atagcgtaga actagtagat
      541 agctactata gcacagctta tgttgttgaa atggaagttg aaaattcgac cgcagaagaa
      601 ctctattttg acgaatacta tttcagtctc atggatcctg ttagtcagat tccctttacc
      661 ctggatttgc ggacctatga tgtgaatcta gttgaaaagc tgaagccagg agagaaagta
      721 caagtaaaac ttatctacgg tatagataat gaaacaaact ttggttttac ctacgaagat
      781 gccatgtgga cggaattagt cgcagaaggt atctaattgc tgtagaaaaa gttttaaata
      841 ttgcacaatt ttgcgggttt atacgcccct tggttcagat tgatcggctt ggtaattgta
      901 ctatatccga cttatctatt atttttacat tttaaaaagg agaacatgtt tatccactgt
      961 tctcctcttc ttttaatgaa aaataccccc aaaattagca cgtcaatttt gggggcgttt
     1021 ttattatagt ttagtaaact aaaagtaagc ttataccaaa ccttgggcaa tcatgctatc
     1081 cgcaatttgt tcaaaggctg cgatgttagc acctgcaagg tagtctgtac caaggtcgta
     1141 tttttcagca gtttctttgg ctgtgttgaa gatatttgcc atgatgtctt taagacggcc
     1201 gtctacttct tcacgagtcc atgaaagacg aaggctgttt tggctcattt caagggcaga
     1261 tacggctaca ccaccagcgt tggcagcttt tgcaagaccg taaagaacgc cgttttcttt
     1321 gtaaactttg atagcatcaa ggtcagatgg catgttggca ccttcagcca cacagtaaac
     1381 gccatttttc acaagggcag cagcttgctc gccgttgatt tcgttttgag tcgcacatgg
     1441 aagggcaata tcagccttgc cgtcgtagtt ccatacagaa ccttcgaagt acttagcagt
     1501 tgctttttct gcagcgtatt ctgtcaaacg agcgcggcgt ttttctttga tgtccaccaa
     1561 gaggtcgaag tcgataccag tttcgtcaat gatgtaacca tttgagtctg aaacagagat
     1621 gacttttgca ccaagttcag tcgctttttg aacagcatat tgggcaacgt taccagaacc
     1681 agagataagg actgtttggt ctttgaagga tttaccgttt gctgccaaca tgttatcagt
     1741 gaagtaaacc aaaccgtaac cagttgcttc tgggcggatc aatgaaccac caaagccaag
     1801 aggtttacca gtcaagacac ctgcatcaaa ctggcggagg cgtttgtatt gaccgtacat
     1861 gtaaccaatc tcacgaccac cgacaccgat gtcaccagca gggacgtcaa gtgaaggtcc
     1921 gatgtgtttt tgcaattcag tcatgaagct ttggcagaag cgcatgattt cagcatcagt
     1981 ttttccttta ggatcaaagt ctgaaccacc tttaccaccg ccgattggaa gaccagtcaa
     2041 gacgtttttg aagatttgct caaaaccgag gaacttcaag atggattggt ttacagttgg
     2101 gtggaagcga agaccgcctt tgtaaggacc tacagctgag ttgaactgaa cacggtagcc
     2161 gcggttgact tgaacatttc catctttatc tgtccatgga acacggaagc tgatgatacg
     2221 ctcaggctca acgatacggg ccaagatgtt ttcttcgatg tattctgggt gtgcttcaaa
     2281 aacaggctca agtgtagaga agagctcttc tacagcttga aggaattctg tttcatgtgg
     2341 gttgcgggct ttgactgctt caaaagaagc ttggatgtaa gctttggcat ttgacatggg
     2401 atcacctgat ttctttttta ttcattaaat tgtctgacaa tttaatttat ctgataatta
     2461 ttatagcacc atgattttta aatgtaaaga agaaaatgta agaattttaa aaaaattaat
     2521 aaatttttat tgcaaaatcc gaacgttagt agtaaatggg gaaaatccgt ttgtttctta
     2581 tgatataatc aagaaagaat gacctatatg gaggataata tggtttcaac agcaacgaca
     2641 ctcggtggat ttacctttga taattgtttg atgaatgcgg caggggtttg gtgcatgacc
     2701 aaggaagaat tggatgcggt taagaactcg aaggcgggga cttttgtaac caaaacagca
     2761 accttggact accgcgcggg taatccagaa ccacgttatc agaatgttcc gcttggttct
     2821 atcaattcga tgggtttacc aaatcagggc ttggcttact atttggatta tctactagaa
     2881 ttgcaggaaa tggagccaga acgcacattt gttttatctt tagttggaat gtcgcctgat
     2941 gagactcacg agattttgag aactgtagaa gccagtgatt ttaaggggct gacagagtta
     3001 aatctttctt gtcccaatgt ccctggaaaa ccgcagattg cctatgattt tgaaacgaca
     3061 gaaactatct tgcaggaggt cttcacttac tttaccaaac cactcggtat taagttaccc
     3121 ccttattttg atattgtgca ttttgaccaa gcagcagcga ttttcaacca gtttcctttg
     3181 aagtttgtca actgtgtcaa ttcgattgga aatggtctct atatcaagga tgaatcagtt
     3241 gtcatcaagc ctaaaaatgg ttttggtggt atcggtggag agtatatcaa gccgactgct
     3301 cttgccaatg tccacgcttt ttaccagcgc ttgaaaccgg agattcagat tgttgggact
     3361 ggtggcgtct tgacaggtcg ggatgccttc gaacacattc tctgtggagc cagcatggtt
     3421 caagttggaa caaccctgca aaaggaaggt gtggcagcct ttgaacgcat tacggctgaa
     3481 ttgcaggcca tcatggctga aaaaggctac gagaccattg aagattttcg tggcaagcta
     3541 cagcacttag atgactgaga tcatctgttg aagacataaa aagaagctaa cattgtactg
     3601 ttctcccaga tagtctttta gggagttagg aaggggtaat gttagctctt tttaaatggt
     3661 ctgtgaagat cggtctgata atcgtttgag gaatggaata cataatcaga aacatatatt
     3721 tgtgagatgg aattttgatt ttgtttagat tttttagcaa aaatgtcgta tactaatatt
     3781 agaacctcta tttataagtg atgtactttt atggaagaaa tagttttttg agggactact
     3841 gactgtattt tgaacaaagg ttcttaagta gggagtatga gggtaaaggt atggagaaaa
     3901 gagcgaacta tattcgcaga aaacgatatg cgtcctatcg gacaaagatg catttgtttt
     3961 ttatttgtgg cttagcaact attatcttgg cgattattat tgtaagcgag cgcctagttc
     4021 ctaggctgaa tcaggcatca gaatcaatgc gctcagataa ttctgttcgc atcatggctc
     4081 atggggattt gctctatcac ttgcctattc ttcgaggagc agaacagcca gatggaagtt
     4141 acgatttttc tgagaatttt acctacgtaa agccctggat agaacaggct gatttcgcta
     4201 tcgcagactt tgaagggacc atttccccag atgtcgaatt agcaggttac ccacttttta
     4261 atgcgcctgc cattgtcgcc gacaatatcc atgatgcagg ctacgatttg gtggacttag
     4321 cccacaatca tatcttggac tcacatctat cagggctgat ttccactgtc aatacattta
     4381 gagatgcagg tgtggataca gtcggtgtct acgccgaagg caatcgtgca actgcaccac
     4441 tctacattcg ggaagtcaat ggtatccgta tagctgtcct agcctatgct tacggtttca
     4501 atgggatgga ggctttgctg agtcaggagg aatatgatgc ctatttatcg gattttgata
     4561 aagaaaagat gcgggcagag attgagcgag ctgagaaaga ggcagatatt accatcgtca
     4621 tgcctcagac gggtgtggaa taccagttgg agcctacgga ggaacagacc agtttgtacc
     4681 atcaaatgat tgattgggga gcagatatcg ttcttggtgg gcatccgcat gtagtcgagc
     4741 ccgcagagat tattgaaaaa gatggtcaga gaaaattgat tatctattcg atggggaatt
     4801 tcctgtccaa tcagcgtatt gagagcatgg atgatacacc aaattcccag tggaccgagc
     4861 ggggtgtctt gatggatata aggattcaaa aagagaatgg gcagacaagt attcggacag
     4921 cccaagcgca tccaacctgg gtgaatcgta tctctcaggg aacgtattca caagatggat
     4981 atgagcgttt tagctatcag acctatgtat tggaagactg ggtcgctggt ggtcgatatt
     5041 atggacaatt ggatctagat acacaggcgc gtgtggatac agcctatcaa gaaatgaaag
     5101 actttgtcaa tttggtatgg tgaggagaga gaagatgaca gttcgattaa ttgcaacaga
     5161 aatcggagta aggaaattga tacaatagaa tacagaaaaa gccttggaac tagctgtttc
     5221 caaggctttt tagctgtccg tagatatagt ttcaatgcta ttaaagatga tgcgttttgt
     5281 ttagacacct ttgattcgtg aatcgttaaa ttgtatgttg ccaaagacag accacatcga
     5341 gtgtgtagca ttgctcgtaa aagtttagaa atcttggaac gaaagggata atgaaaagcc
     5401 ttaattgtaa ggctttttgt catatagggg gtaagtatca gagtgagagc acaagttgag
     5461 tgttttgatg tgataggatg tctaattgta ttttagctct ttatttctct ttcttagggc
     5521 aatgagctca tgctgctcgt cggtcagaat atcaacagac ttgaaggaac cggttgtttt
     5581 ggcttgtctt acccacttgt caaaggttga aggggtcaag ttatactcct tgatgtgttc
     5641 actccgcttt cttcctgcct tgtgaagctc aacaatctgt tgcttaaagt catcggtgaa
     5701 gtgacggcga attcttctag acatatagtt ttctcctgtt tttctcagta tagaacactt
     5761 tataatttct gtccagtcta gtgcaacaga ttcaagtaat ctcatttttt aggatttaga
     5821 gtatttaatc tgcaaaattt ttatttaaag cttcttcgag ttgaagatac ataagatcat
     5881 tatcgtagat tttacaaagg ttctttgcgt ctgtgtaata ttcttttctt ttatctttag
     5941 ggagaaattt ctctccagcg tttgcaacaa tcgttaatag gggggcgagt tgataactag
     6001 tgtgatgtag tttgcataat tcaatcgttt gcatcgctat ttttatagca gagagtggtt
     6061 ctccctgttt ccataagtgg taggagtagt tatactgaat ttttatataa ccaaagagat
     6121 aggtagaaac ggaaagatcc ttgttttggt attcttttac tagttttttg taatttgttt
     6181 catatttgat aatttgatta gttaaagagt aaaagttgga tagtgtattt aaaatattta
     6241 aataagttat ttcatgatcg tttaccttat atagtaaagt ttctaattga gaaatagctt
     6301 cttctttttg atgatagttg tagaaaagaa ggattgcatc aatccattca agataacaat
     6361 tatcatcatt tgaaagcacg gaattattat tgcgttcaag aatagtgaga tattcaagtt
     6421 ctttatagtt tctatcttct aacaattttg tcgcaattga cttaaaggat tcgaggtttg
     6481 agtgaataac gatatcttca tcaaaaaagt actccataga aatttctaat cgtttagcaa
     6541 gtttgttgag taattttgag gaaggattca ctaagccacg ttcgaacttg ctaagttgac
     6601 tgggttcaca aattccctca gctaattctt tttgggatag atttttttgt tttcttaaaa
     6661 tttttaatcg ttcacctagt atattattca tatgttccct tttcaattta aagttttaaa
     6721 actattatat ctactttttg ctaaaaatgc aaaccgcaaa aatgtcatat agtaatgttt
     6781 tttaaaaaaa gttcaaaaaa gacttgatat tttttaggaa aatgatagaa tatatttaag
     6841 aactaagaaa gggttttcaa tatgatgcga aaattaaact taatgctaaa gatggctctc
     6901 gctttaattt ttgtgtttgg ttttgtgtct aaaatgccga atactcaaat tattgatgat
     6961 aaaacgttaa tttctcacta ttcctaccat tctaacattg taaattttga tgttgtggat
     7021 ttaggtatgg ctgattgagg catttcgata ttttaattct gaatagtaga gaaatgaaga
     7081 aaataaacgt ttagactgac gaggttgtcc tttgctctaa aaattaactc gtgtcatctc
     7141 taaatacgaa tgtatgggtg ctaggaggaa tataaaatgc aacatcaagt aatacagaca
     7201 tccaatttgt caaaatcgta tgatgggaga attatccttg aaaagataaa ttttacgcta
     7261 aatcaaggag agatttatgg attactagga agaaatggtg ctggtaaaac aacttttatc
     7321 aaggctattt tagggttgat agagatggat agtggtgaag tgaggattct atccgaaaaa
     7381 ctgtcagggg aattttctaa ggatttatta tatcgagttg gtgtggtact agatagtgca
     7441 gctttttatc ccaacttgac aggtaaagaa aatctctcta tttttgcaaa actgagaggt
     7501 atttctctaa aacaggtaga ccaagcttta caagttgttg ggttatacgg agaggatagg
     7561 aaattattca agcagtattc tctcggaatg aagcaacgct tggcaatcgc caatgcgatt
     7621 atgcaccacc cgcaaattct gatattagat gaaccaacaa atggtttgga tcctattggc
     7681 atccttgaaa tgcgtcgcta tttaaaagaa cttagtacta atcaaggcat ttctatttta
     7741 atatccagtc acattatttc agagcttgaa aaacttgttg acagagtggg aatattgcac
     7801 aatgctcact taatagctga aaagagtatg aaaggactag taagtgacac agagcaaaat
     7861 acagttcatc taaccgtttc tgatgcccac caggctaagg aagttctttg caaattcaaa
     7921 ctgaaaggag tcgtaagtat tctttctgat gtagaccttg aacttcaggg aggtccatct
     7981 gattttgata ttgcagctgt ttcagctatt ttaaaggaaa atggaatagt cctaaaagaa
     8041 tatttctata gaaaccatga aagtttggag gattattttg agcgaataac tggaggtgag
     8101 ggaattgctt gagttagtaa aaattgaatt tctcaaacaa aagcatcaaa aactgaatct
     8161 ggttgtatat ggtgtgattg ctctctatct agctcttatc ttttattatg taaatgatgc
     8221 acgaggtttg tttgactctt ttccatttgt ttataaattt tccttgtctt atttgaattt
     8281 tttaattctc cccttgtact gtgtctctta tactatacag gcgtttggtg tggaatatcg
     8341 ctataatata ataaacaatt tgcaacttgc ttcagcgaat atgctcaaga ccttttgggc
     8401 taaggtattg tatatagaaa tcaatgctct gttgattatg atgtttacat atgtttccgt
     8461 ttccttattt gcattactat cccgattttc ttcaacggtc acattgcttt tattgctaag
     8521 atttttatat ctatgtatta gcagcggttt gttgattcct gtgggtgtat ttcctttagt
     8581 tgctttcgtg atgattaaag gaaaaggaaa ggatatcatt gggaatttgg taggagtcat
     8641 ctatgttttg gtatctttct ttctagcaag gacaagccca aacatcagtc caattacaag
     8701 tgctactagt ttaatctggg aaggaaatag cgaaggagta gttctacaac agccggcttc
     8761 cgtatcaagt attgtcttag gtttatcttt atttgtctta tcttttctat ccattaaatt
     8821 ctggttaaga aaggcggaaa attaaatgtt tatgctcgaa ttaagcaagc tacgacgtcg
     8881 caaattccta tatagtctgc ctttggttgt catttttctc tttttgttgg aatttgtgat
     8941 gggtaatcag ctgtatcaag gacatcgata tggtagtgta aatggttggt atttggaaaa
     9001 tggcttcttc tttttgaact attattttct ccttcctttt tcaagtatga ttgtagtgga
     9061 tttgataaga atagagcaag actctgaaac gattgcgaac cttagactga ttccagtgga
     9121 tttaaaaaga ctcattcaat caaagtttat tcttactttg ctgatgaatc tcttactcag
     9181 tgagctgatc tttcttgcaa tgcttgtact cgagatgata gatggtgaac ttgttttttc
     9241 taatattact ctgttatcgt gggtgattgg atatggagta gtagcttttg cgtatacact
     9301 atttgctaat cttattgtcc tctttttagg aaaatgtagg aggcaactta tcctcgcggt
     9361 cccttttgca ttcctactgt catttgcagg cttgtttacc ttgtcaacag cttttgggca
     9421 gtattatctg gtaaatttac cattgctcat catgaaggag tttacacttt tgacagtttt
     9481 tgtatatgct atttggtttc ttgtcttact gtcctgtgtc tgctattttt tagcagatag
     9541 agggatgata aagattattt tcgcttataa atgactgtat tagcctaaat tagggaatac
     9601 agcgtattta aatatgtgtt actggtatct cttaatccca aaggtttaag atgtcactat
     9661 gtttaatcag ggataacagt agctagaaag gaaattatca attatgtctg attggaaaaa
     9721 acctatttac gaatcactaa gtacagaagg taatccagct ggagatatct tacgtgagct
     9781 tagtgagagc gagatggatc aagctatggc tggtggaaca gctagatctt attgtggatg
     9841 ttattcaggc gagcactcct gtggacgtgg ctgtactatt accacagagt gtcctttctt
     9901 aacatttata tgttgttaat agactaactc cattaaatct ttggggaggt gacatctgga
     9961 aatagggtgt cacctgttgt tttatattga ggagcttaaa atgaatagag aaataaatat
    10021 aacagaattt aaagatgctt cttatttttc tgaaagaaga gttgctagca ctgatgtaaa
    10081 ttattgttta aaatcgagaa aaagaaaaga atattgggat aagtttattg gagaaggagc
    10141 tgaggagttc tgggaatact taaaagaaaa aaatggtttt tctaaccagg atttaaatat
    10201 ttttctagaa gaaaacgaat atgacgtaga agaaatagat tcatttttat acatgaataa
    10261 atttataaag ttttattttg aaaacaatga ttatccatta ccagattttt atataattga
    10321 cagcaaagga aaacgaaaac ctatttttag taaatttgtc ataccgtttc ttaaatttgg
    10381 tgcatataac cttgagggcg atttaaatag taaaaaactg aaagttacta gagaagtttt
    10441 gaatagttta ttagtcagtt tatttcaaca aattttgaat atctcttata gaacattgat
    10501 attagaatta caagttctga aggaacaaaa aatgctgaag ggtaaaactg gtgagaaaag
    10561 gtttgaatat ttttcagaaa tatatttatc ggacaatttt tgggatattt taaaagagta
    10621 tcctgttatg tttcgtctaa ttattgaaaa tgttcaaaat tgggtgatta ataatgtaga
    10681 atttttaaag catttagaaa aagataaatc attattacat aaatatttcg atatcaatga
    10741 ggagttaact aaaattgaat ctggtatatc tgattttcat aatcatggaa aatcagtata
    10801 tattctttgg tttggtacga ataagttagt gtataaaccg agagatttaa ccttggatgt
    10861 aaagtttcaa aaattactta gctggtacaa tctgagattc aataaaaatt tatacgtaac
    10921 agatattctt gatcgtggaa attatggatg ggtggagtat gtagaacatt taccctgtac
    10981 aaatgaatta gattttattc agttttatac acatctaggg tacttattgt ttttattatt
    11041 tgctatgagg gggaacgata ttcattttga aaatatcatt gccagtggta ataggccagt
    11101 tcttgttgat attgaaacat tattccacaa tacaatagag tatagagaaa aatatgaaac
    11161 agcagataaa ctgatattct ctttattgga aaaatctgta aaaagagtag gtattttacc
    11221 taatatagtt tgggggaaag atgggaactc tggggtggat attagtggtc tgagttcaag
    11281 tgcaggagag gtgattccaa ttgaacgcgc aagtatcatg catagtatga ctgatgatat
    11341 gaaaattggt tatgaacaat ctgtcttaca agataaagaa aatcaaccgt ttattctatc
    11401 aaacgaggat gttgatttga atttatacaa aaattacatt tctgctggtt ttaaggaagc
    11461 ttatgaaatt atctcaaaag attcttcatc agttgaagaa tttatgattg agatagaaaa
    11521 atttagcgat acatattcta gacaaataat gagacccacc caattttatt ctaatttaat
    11581 acaaacatct taccatccta gttttttaag gagcggtcta gatagagaaa tgttattttc
    11641 aaaagtttgg aaaatagttt tcgaagataa aaaagtgcaa agaatagcta gttcggaatt
    11701 tgaatcatta ttattggggg atattccatt atttcagaca aaaatatctg agagattctt
    11761 atattctgaa ttcatggaat atcgaaattt ttttaatatt tcagggcgag aattagctgt
    11821 tcaacaaata aagaattttt gtagcaaaga tatggaattt caactaaatt tgattgaaac
    11881 agctttaaat tatgaccctt cctataattt agttcaagat tcctttgtct ctcgaacatc
    11941 ctctataaaa gtgatacaca gtttaaatca gagagaaata caagaaacaa aaaataggat
    12001 tgtacccctg gcagaaaaaa ttgctaatta tttatctgga atttcatata gtggcacttc
    12061 aggagatgta ggctgggtag acatgaatat acttggagaa aaaacaaatg attggaatat
    12121 ggttccaatt ggatgtgact tatataatgg tatatcaggc attatgattt tctatttatt
    12181 tttatatttg gaaactaaga atgaagagta tcttatatat ctaaaaaaat gttaccagtc
    12241 acttaagtat tacctagatt caagaaaaca atttgttact cactctcaca tattatttgg
    12301 aggtttttct ggagagaccc ctataatata cgtattgttg ttattgaaga caaggatagc
    12361 tgaacacttc gatcctgaag aacttgatgt ttatatctat gatattattg atgatctaaa
    12421 acaaggatat agacaggatg aaaattatga tgttcttgta ggttctgctg gagcaattgt
    12481 acatttatta aatgtgtttg aagtgactaa agatgaagaa cttttagagt tagcatatag
    12541 tttgttttgt catttagaga aaaattcttt aagaattgtt gttgatggtc gggatggaaa
    12601 agcatggaaa gggacgatgg cttcaaatcc tttagcaggt tttgcacatg gagtttcagg
    12661 gattgtatgg tcattatcaa aacttagtag atacttccag aaagataaga gacttaaaga
    12721 tataattgaa caaggtataa tttttgaaaa ctctctgttt gatactgaaa agatgaattg
    12781 gtctgattat agagaaactg acagtggtat caaatataaa gatattgtcg aaaatattcc
    12841 tgtttcatgg tgtcatggtg ctccaggtat acttttaagt agattggagt tatataaaaa
    12901 taacacttta aatgtagagt ttcgagaaaa aatgaaatct gatatggacg tagctattga
    12961 tacaacaata aaatatggtt ttggtaaaag tcattgtcta tgtcatggtg acttaggaaa
    13021 tctaagtatt ctactttatg ttgctgagaa aacatcttct gattatttat atagtgtggt
    13081 ttattcctat ttaaatacta ttcttgatga tttggaatca gaaaattgga aatgtggtct
    13141 tccgtataaa aattctccaa gtctaatgag tggtatagct ggaataggat taggactact
    13201 aactttaaat aatccgtcaa ttccttctgt aattaatcta gaaatttggt gattcaaatt
    13261 gaaaaaggta aaattcatac aacaattatc taacactagt tgtggtttag catgcttagc
    13321 aatgatttta gactattatg gctatgagac aaatttatat gaattatgct gtgatttcga
    13381 gaattcaaga gatggattgt ctattaaaga tattaaaaat atagcttcta attttggaat
    13441 ggatgtaaaa gcgattgagg ttttaaattt taaaaaattt ttttcggaaa aatttgtaga
    13501 accttatata gctttaacta gtaatgcaca ttatattgtt gtagaaaaac atgatgaaca
    13561 taatgtgata ttcatcgatc cagaaaaagg tagaatgaca gaaaatatat cagaattcat
    13621 gaacaatgca tctggtattg taattttctg ttcacctaat gaaaaattta ccccaaaaaa
    13681 gaaatacaat agttttttca aaatattgaa gataggtgaa attgatatca aaagattatg
    13741 ttatatttct ttaatatcaa tcgtggtaca gagtttaact ttattattac ccttggtaac
    13801 aagatatatt attgacgatg taattagcag aagagaaatg taccgctcgg gaatgattat
    13861 ttcaatcttt tctttaatta tattttatgc attgtttagc ttgatacgga ctaaattaat
    13921 gattacagtt gaaaagaaat atatatttac actaaaagat acgattgtta gtaagatttt
    13981 tactctacct atgaaatttt ttgatagcag atcttcgggt gaaattgtat ctagaattaa
    14041 tcatttagat tctttagaaa aaataatttc aagcggaata tcaagtctat taattgattt
    14101 atcgactgtt gttatcgctt ttatagcgat ggcactgatg tcagtatatt tcacgcttat
    14161 aattatgttt ttcgccatgt ttttattcgt agttttgtat tttttgttaa aaaagttaga
    14221 agaaaagaac tcaaatttta taagatctaa agaattgacc caaggttatt tgatggaaat
    14281 tttctcaaat ctattatttt tgaaagtctc agcaagagga gatgtttcat attcaaaatg
    14341 gaaagaaatg tttagcaatg agcttagatt tgatgtcgaa cgtgagaatt atttaaatat
    14401 ttttcagact tttatttctg tatacaggtt gcttcctaat gtactaatct taattttagg
    14461 cagtatagaa gtacaacagc atacgatgtc tcttggtagt ttaatgtcat ttttatcatt
    14521 ggtttcttta gttctttcac caattgctct gattgtacaa aattgttttc aatttcaatt
    14581 ttgttttaca attttggata gagtttttga tatcatttat accccagaag aaaaaaataa
    14641 attctcgatt tcaaaaatgc ctgcattaaa aaaaataact tttagtggct tgaacttttc
    14701 ttatggtggt gggagcaagg ttattgatga tattgcatta actattagga gaggtgaacg
    14761 cattgctata gttggaaaaa caggatgtgg gaaaacaaca cttattaagt tattgctaag
    14821 attatatgaa gtagaggagg gcactgtttt atataatgat aacgacatta atttgtttga
    14881 tttaaatagt tataggaaga attttggtgt tgttttacaa aatgatgtaa tgtttaatga
    14941 cacaattctt tccaatatag atttgacgca tagtcattct atggaagata ttattactgc
    15001 agcaaaccta gctaagctag atacagagat taataatatg cctatgggct attatactag
    15061 cgttggagat aatggtaata atttatcagg tggacaaagg caacgattag caatagcaag
    15121 agctattttg caaaatccag agattataat ttttgatgaa gggactgggc aactggattc
    15181 catcacagag aaacaaataa tggataattt aaaatataga ggtattactc aaatatttat
    15241 tacccatagg ctatctaatg ctaaggaata cgatagtata gttgttatgg acaatggtaa
    15301 aataatagat attggaaaac acgatgaatt atgtagtaaa gagggaatgt acaaaagact
    15361 atttgaagct tcacatagtt aaaaaacaag cctctagaac cttatttttt aaaatcggct
    15421 ctggaagatt gtccaaaagg tgtctcatgt atgttccggc tttaggacta atagctttgt
    15481 cggtttcaag taagcttttg atagagaata tgctttgagc acctgttcgt ctacttgaga
    15541 agagctaaca tttgcgtctt attacttact cattaacatt cttccctgct agattattgt
    15601 tcaagatgag attgagatgg ttaaggactt gacgcaattc tttttcatgg gggagacagc
    15661 agttaacggc tttgtttagc tttaagtcgt gtaagatatt ttcatttcga cagtaagtaa
    15721 agaagtattc ctcctaaaag atgggtatga tctttctcaa aaatgaacag gcaattagta
    15781 ttctacatct tttgacagat tagactatct gagatggtgg ccttgggata agcgctatgg
    15841 aagtagcacc cttacatgca cctagtaact gactaaagtg acattttcca aatttaaata
    15901 cacgtctgtt tgtagataat caggagaata tcccagaatc tctttgagag atgaggaata
    15961 atatgggtag ctgaaatatt cttctgacaa ttcgttgtat tgatctacct gagggagttg
    16021 agataaatca gctggatgct tttctcttgt cttctgacat ttgtaggtaa ttacctaagt
    16081 ttctttttga gtaactcgaa gtcgttgaaa actttagtag gtagctttat ggtaaagcgc
    16141 cagaggagac gaatttggtt cttagttttt ctttaaccca ttacagcctt atagagtcga
    16201 aaaatgcgag tagttataat gcttttactg ttcaataggc ataaagtttc ctactatttt
    16261 ccctataatt cttggattat ctacagctag cgcaaactta tctggatagg agtcgttcat
    16321 ggagacgagt cgatagccat cttcctcaag ataaactttt ttgatgtaaa cttgctcatt
    16381 ccaagcaatg gcataaaccg ccccgtcgta gtcaaagcca ccttcacgga ttaaggctac
    16441 ctcacagtct tgataaacag gttccatgga ttgcccctca atccaagtcg ccacatcgta
    16501 gaggtactct ttatctgtaa agacttcctt ggtctcgtat tcatcccaga taccgttact
    16561 atgtccagct gatagagcca cattgtcaag gacacggact gaaaatagta ggagaacctt
    16621 ttgttccatg agaaggtctt gaattaactc atcgaccttc tttttgttat gtgactttga
    16681 gtccgtcacg ctccgtaagg tgtgtgacaa ataaactacc cgctatgcgg gtacgcgatg
    16741 aagattatac caaaaaactc ctttgcttta caataaagtt gttcaagcct attgtaaagc
    16801 aaaggagaaa aatatggtgc aaaaggcaca tagtttatca catacaaagt ggttgtgttc
    16861 taccacattg tcttcacacc taagtataga cgaaaaatca tctataatca atatcgaagt
    16921 agtttgggag aaatattccg acgtttgtgt acttataaag gtgttgaaat tatcgaaggt
    16981 catctgatgc cagaccatgt tcacatgtta gtcagtattc ctccaaggct aagtgtatca
    17041 agttttatgg gctatttaaa aggcaagagt gctcttatga tgtttgataa acacgccaat
    17101 ctcaaatata aatttggcaa tcgtcatttc tgggcagagg gatattatgt aagtacggtt
    17161 ggacttaatg aagccacaat taagaaatat atacaagaac aggaaaaaca tgatatagca
    17221 cttgataagt taagtgtaaa agagtatgaa gatcccttta gggataatgg caagtagtac
    17281 gaatgcctct ttaagaggct agtgacgagt caaaagcagt gaggcttgaa caaagtgaaa
    17341 gccggcgtct ttaggcgctg gctggtgatg tgggcttata gcccttgttc aaaccacccg
    17401 tttgacgggt ggtcatgatt tgtaatgtct gttgtgtgaa agttcatact tattcaaaga
    17461 gtttacctaa atgtagagac aatcggaata atctttcagt ttaatataga gtactcatta
    17521 ttcaactcat ggtataattt ctacaatatc ctcaatatcg caatctagtg ctatacaaat
    17581 ccttagaagt acatcggttg ttacgttttc tccctttcct aactttgcaa tggttgaaga
    17641 gctgattcct gctttttgtc gaagttctga cttagtccac cctttatcaa ttaacagctt
    17701 ccataatcca ttgtaactaa atctcatctg aattttctcc tttgttccat gaaataccgt
    17761 agagttcatt tccgttacta gagagtctca gtacagtatt ttctgacaag agttgattag
    17821 cttctggaga ataagagcta gctttatcaa aggctaaaaa gacttgtttg ttcaatgact
    17881 ttgatcgatc atacagcttc aaaagtgcct cagtcgcttg gtagctaata ttactcaaga
    17941 gtaatgagtc gtgtgccagt gctggcaggt tagtgagata gagcatggtt aggtcaaata
    18001 aaatcatccc tttgaactta gttcctgtac catcatcatc tggggtatag aaggagtagc
    18061 tgttgtgagc tttgaggtta atttgaggag ctttgcgaat atctgggtag aggacattat
    18121 tgaactctcg cattttagta ttgatttttc cttctaactc tattagaata tcttcggtgc
    18181 tacgcttcaa gtcagagtct gcttctgact tttcttttga taaagcagac tctttcagat
    18241 aggctccgtt ttgctctttg agtgcattga tcattgctgt tagtttagag tagttttcta
    18301 agaactcagt tgaaagattt gggatgcttc ctagttcttg aagttcccta tttaaaactg
    18361 tcagttgact ttctaatccc tcgatctcaa gacttagcgt ttcacgttcg gttgagaatt
    18421 cggaatccaa aatagttgcc aatttcttat gataggcttc aacttcatat aattttttga
    18481 ggttagtatc agggaaataa cgttgaagct ctgttaagtc agattcagta ggatataaac
    18541 caaattcgat actgatatcc aatagtttaa ggcgtctttg cttatctcga agactgtttt
    18601 ctagctccag cttagtattt ctaagttgga ttttttgttg atttttttca atatcatcag
    18661 agtcaatttt atcttgatga gtatcttgga ggtgtgataa atcatattcc aatcttttta
    18721 tttctgagac attcgcttca aattgctttt taccacccac taagttagag atgaaggcat
    18781 attttcgagc attacgaaat gttgttaact ggtcgctctt atccttcagg cgttctttgt
    18841 atcgtgctat gttatcgtac aaattaaaaa gctggatgag agtggtaata gattcagaag
    18901 atttttggct cgaataaact tgtaagggga aatcggtatt ctgattgttt tttcctgcaa
    18961 tcctaaagaa cccactcata gctaatcgga atgataattc tggagaatct aaatgatacc
    19021 gtttcttaag tttgttcaga aagttttcca ggggcattgt ttcgccagtt ggagaataat
    19081 catcgttaca atatgtgatg atgtctggag ttgctgtatc tcttgaaaaa taaaactttt
    19141 tctcaaattg aaagcagaaa tagataggat gatcgcctaa tttcttaacg gcgatagatt
    19201 tttgatagct gttacctcca aaaatgaaat caatgactaa tagggaggag gattttccga
    19261 tagagttatc agctaaatcc atacccatga taacattcaa tcctggatga aatcgaactg
    19321 gtttccgagt ttgcccattc ttcttaaaga cgggcgacca catttctata agcataaatt
    19381 tacctctcct tcattagaca tttcaatggc gttcaatgca tacaagcaat ccattatgga
    19441 taggaaatct gtaggatcat ccaactcttc tgagatagcg tgaaagatat ccttgacgtt
    19501 tgagtttcca cttttaattt catttagcac tttaggtaaa taggccagag tgcttttttg
    19561 ataggagtaa agtttatttg gtaattgcat tattcaagta cctcacattt ttggataaag
    19621 taagagacaa tcatctggca gaagtagatg tcctgtagtg tagctttatg gagtttttcc
    19681 gaaatagtat tgaaaatcgc tagattatca tgcttggtag cctttaactt tttatacatt
    19741 gatcgcattt ggtattgaat ttcctcgtaa tcaatttttc cttgtttgtc caaatttacg
    19801 atgatttttt gaatggttaa gtagttatca ataacttggt ttttaaccat ttgatagagc
    19861 gtacgattat tctcaggcga tatcttatca gtcaattgct tcgggtcata ggagatgtca
    19921 tattcatcaa atttgagttt attgaggcca gtcaaaacag cgacaattcc attatctaac
    19981 ttcaagtcag aaattggtcg ttgactgtta tgtgtggata ctagaatctt tttaacattt
    20041 tttaatgcta ttacagtttt tttgcgatta tctgcttgat aagttaaaaa acaatctggg
    20101 cagagggcta tcagatttag tggttcagcg tccttatctt tttcaattac tgaaacctcg
    20161 tagttttctg tggctaagtt gccactggtt agaatgagtg gtctatcaca ccctgggaag
    20221 gcacaacagt tatttgcttc cgtcaataag aattgtccat attgtttttt gagttgattc
    20281 gactggttaa caaatgtagc tttttgagct gtggttgata ttcccatccc agctttctct
    20341 ctgatgaaat cgacaaaaat ttctggaatt ttttgagagg cattctcaac agtaatatca
    20401 ggataatagg agttaaattc ctcggctagt aactgaatag tttcatctgg tctactttca
    20461 atagactccg tcatatttgc tgagttgacc cgatagagta attgatttgc catcttcttg
    20521 gagaagcttc ttttagcata ggaaactagt gtattatcag ttttttctga tgtaattcca
    20581 gaagcgctga tgatttcttc tgcgtcatct tcagtaatca tttcaatgag ttctcgaaaa
    20641 aactctggta tagtcgcgcc atctccaaga tattttttca gaattctaaa ataagtggga
    20701 aaatccaagt gatgttctcc ttttcatttt tgtaccaagt tgtaccgtac tgtactaaac
    20761 tatcccttaa ttcaaaatct cattttatac aatagagtcg aacaaagaga tcgttagtga
    20821 ttagttttat tatatcatga cgaggttgcg atgttcgaaa aaatatttgc gaacgcataa
    20881 aaaagtttgc gaatgtaaaa aatcttgatt accgaatagc gctaataggt aatttgagat
    20941 agttgttgcc taatgatgat actttgtaaa tgagtgaaac tgatttaccg tgactttaag
    21001 ggtacgaatt aggtatgcag ttcagcttgt aaagtcagtt gaccatgagt tagcagagga
    21061 attgctgatg tggtcagaaa atctttttaa tagttctttg tcttgtcacg tttctctgct
    21121 taagacagaa agtggaaaac atgacaaaca aggacaatat ttataacgaa tgtcaaaagc
    21181 aggaatgctc gctagaagtg ggacttttag agggacaggt gctagctcct atgctagttg
    21241 agaaccaaca agtgattgag gatatgcacc ttaaaagaga gacccttcgg tcttggagac
    21301 cggctaaaca gctgaatgtt tatgttttgg ttgcttttat tccagtctat cctgaagagt
    21361 atactcaaac ggaacgtatc tacaaagatg cagttgagaa cttcttaagt gaattccgta
    21421 cacggaagtc taagaatatt aaggaaatca tttcatacga atcatggata gatacagatg
    21481 aatccagttt tcacagttct actaaagaat tggaagagtt catgttcgca gaaatgctac
    21541 aagttttact tgaaaaagta aggcaagcag ataaggactt gtatgatatc actttgggct
    21601 tactcgccaa agagtttgat gagagcattg aggatgtgtt cgctaggatt ggtgttaaac
    21661 gttctactgg tttctatcgt ttgccaaaag ctcgtgctct ggtggcagcc ttattgaagg
    21721 aattaaatcc gaaatagtgt ttatatttga cactagcgat gtttttggta taatttaaat
    21781 agaagtagtc ggagagtaat accgactcta aaaagaaaat actcgtcagg agattccgtg
    21841 ccttactgga agttttaatt ttggagattc cgtgccttac tggaagtttt aattttggag
    21901 attccgtgcc ttactggaaa ttttaaaagg gttgtcgacg ggcaacccta tttttgtaag
    21961 tgagtgtaat atcaactatg catgaaatga aattttatca aattgatact aattatctaa
    22021 atatactccg tcagattgat ggaagagttc cacataataa agaatttatt ggtcgaaaag
    22081 gaaaatctag accatatatt ggtgtgatgt tgtctattga taatgttgat tattttgttc
    22141 ccttgagttc taaaaagaag cggtcttcat ttgtagtaat gccgatttac gatgataata
    22201 atgaacagat agcgacattg atgttaaata atatgctgcc tgtacctcca aaacacagaa
    22261 aactattgaa tatggaaggc gtaagaacaa ccgaccctaa atattttgat ttgttgatga
    22321 atgaattaaa ctttttacgt cctaaaagag aagcaatcaa atcaagatgt tccatcattc
    22381 gttctgtaaa agtggatgga aaaaataagc ctcagattaa tgagagaact aaagaatttt
    22441 gtctggagct tattgagtta gaaaaagcct acaaagaaaa tgaataagaa aaacggttca
    22501 ctacccaaac aggtaatgaa ccgttttttt gtctaatcct tttggtaaaa ggaacattca
    22561 taaccatcag ctctaaggtt aatatcagat atccagtctg gtgcatgtcc cattaatgtt
    22621 gcaatttcat caaggctttg gtcttgatca cactcaatga tgatttcatc atgaacatga
    22681 ccaacaatct tgaaatcttt tagttgcttt atagaataag caagaatgtc tcgactaatg
    22741 gcttgtacaa tattctcgac gaactttggt ccgtaacttt caagtctctc ccagcgttta
    22801 gctgtgccag ttccttcata tgtgacagac tctccaccaa attggttctc gcccatttta
    22861 ggtttgacgt aggagagttt tcgaccagat ggtaggttga tgaataaaat gccactttta
    22921 acttcaaatt gaatgttatg aacagatgtt ggaattaggt cctttacggc agttttaacc
    22981 gccctgtcta catcccacca gaagagaacg atattcggat tagctagtcg ccatgagttt
    23041 actagtggtt ggagttcttc ctcagttagt cccatatcaa gtgctcccat ggctttgagt
    23101 gcaccgacag agcctccata tccgcaagca agctctgcaa tttttccttt ttgcctgagt
    23161 tcggaatttt gtccatgttt ttcaactggt acaccaaaca tttgtgaggc tgacatgcag
    23221 tatatatctt tcccttcctc aaatacctta ct
//
