LOCUS       NZ_CP101913            20435 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Oceanobacillus oncorhynchi strain QA-1986 526 chromosome, complete
            genome.
ACCESSION   NZ_CP101913
VERSION     NZ_CP101913.1
KEYWORDS    RefSeq.
SOURCE      Oceanobacillus oncorhynchi
  ORGANISM  Oceanobacillus oncorhynchi
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Oceanobacillus.
REFERENCE   1  (bases 1 to 4669308)
  AUTHORS   Wan,K.H., Park,S., Lawrence,Q., Eichenberger,J.P., Booth,B.W.,
            Piaggio,A.J., Chandler,J.C., Franklin,A.B. and Celniker,S.E.
  TITLE     FELIX
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4669308)
  AUTHORS   Wan,K.H., Park,S., Lawrence,Q., Eichenberger,J.P., Booth,B.W.,
            Piaggio,A.J., Chandler,J.C., Franklin,A.B. and Celniker,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUL-2022) BDGP, Lawrence Berkeley National Laboratory,
            1 Cyclotron Road, Berkeley, CA 94720, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 237.47x
            Sequencing Technology :: Illumina MiSeq, Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024508135.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 08:40:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,482
            CDSs (total)                      :: 4,384
            Genes (coding)                    :: 4,315
            CDSs (with protein)               :: 4,315
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 32 of 69
            Pseudo Genes (incomplete)         :: 39 of 69
            Pseudo Genes (internal stop)      :: 13 of 69
            Pseudo Genes (multiple problems)  :: 13 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:15:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 966208
            Orig. end                         :: 986643
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP101913.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20435
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hserlactone"
                     /region_number="3"
                     /rules="Autoind_synth"
                     /tool="antismash"
     cand_cluster    1..20435
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20435
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10435](+)"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10435
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
     misc_feature    729..744
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.42"
                     /tool="antismash"
     gene            861..1532
                     /locus_tag="NP440_RS04825"
                     /old_locus_tag="NP440_04825"
     CDS             861..1532
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NP440_RS04825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NP440_04825"
                     /product="hypothetical protein"
                     /protein_id="WP_042532127.1"
                     /transl_table=11
                     /translation="MKNNTKFLMGMLAFVFVILTACGNVTEDSDAESNRLSSDNDVMQN
                     ENDNLPGQESTQDSSPIDPETETDSFSDWKGKSQDESAEEQSQEEPLEEYVPNEDDVVY
                     KNNELKNKDILEAFMETAGENGQDNESEIRVVKDEGTQGVLIYDLKSGYEESVDQAWIM
                     VYSDLSHYRASDDEVQDVFNTNQQCGYMSKDEIEGKYKLHECRTHWEYRLLPTGEDNEM
                     E"
     gene            1946..2122
                     /locus_tag="NP440_RS04830"
                     /old_locus_tag="NP440_04830"
     CDS             1946..2122
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NP440_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NP440_04830"
                     /product="hypothetical protein"
                     /protein_id="WP_256705732.1"
                     /transl_table=11
                     /translation="MINYDKAKKKIDKRKEMRTQEISEMIDEGGLGADRYYDVIKGSSP
                     TEKEIKSTKKYQK"
     gene            complement(<2617..2952)
                     /locus_tag="NP440_RS04835"
                     /old_locus_tag="NP440_04835"
                     /pseudo=""
     CDS             complement(<2617..2952)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611215.1"
                     /locus_tag="NP440_RS04835"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NP440_04835"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAALPQITLDFNHKIKLSLDGGELSSDTGEMIFRELDEKIGFSAA
                     LAE"
     gene            complement(3216..3971)
                     /locus_tag="NP440_RS04840"
                     /old_locus_tag="NP440_04840"
     CDS             complement(3216..3971)
                     /NRPS_PKS="Domain: PKS_KR (8-164). E-value: 2.4e-10. Score:
                     32.5. Matches aSDomain:
                     nrpspksdomains_NP440_RS04840_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002460763.1"
                     /locus_tag="NP440_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04840"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_256705733.1"
                     /transl_table=11
                     /translation="MFDLTRRIAMVTGGANGIGKGIVKTLAKAGATVMICDIDEEAGKK
                     VAAEVSGEFHKLDVTDKNNAERVVQDILKKHERIDILAANTGIYPDVSIADMTEEDWDK
                     IQSINLKGMFFTAKPVLEAMKKQNYGRVILTSSITGDITGYPGGSIYGATKAGILGFMR
                     NAALEYAPYGVTVNAVQPGMIATETLKKELGVLSEKGAEAVPMKRLGNPEDIGTTVSFF
                     ASEEAKYITGQSLVIDGGQILPETPDVIL"
     aSDomain        complement(3480..3947)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NP440_RS04840_PKS_KR.1"
                     /evalue="2.40E-10"
                     /label="NP440_RS04840_PKS_KR.1"
                     /locus_tag="NP440_RS04840"
                     /protein_end="164"
                     /protein_start="8"
                     /score="32.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="AMVTGGANGIGKGIVKTLAKAGATVMICDIDEEAGKKVAAEVSGE
                     FHKLDVTDKNNAERVVQDILKKHERIDILAANTGIYPDVSIADMTEEDWDKIQSINLKG
                     MFFTAKPVLEAMKKQNYGRVILTSSITGDITGYPGGSIYGATKAGILGFMRN"
     gene            4334..4878
                     /locus_tag="NP440_RS04845"
                     /old_locus_tag="NP440_04845"
                     /pseudo=""
     CDS             4334..4878
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016114692.1"
                     /locus_tag="NP440_RS04845"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04845"
                     /product="HAD-IIIA family hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRQLEAIFLDRDGTIGGDDTVHYQVNLNSFYT"
     gene            5113..5640
                     /locus_tag="NP440_RS04850"
                     /old_locus_tag="NP440_04850"
     CDS             5113..5640
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003154021.1"
                     /locus_tag="NP440_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04850"
                     /product="GNAT family protein"
                     /protein_id="WP_256705734.1"
                     /transl_table=11
                     /translation="MFPVLETERLELRELIKEDAKGIFACFSNDKVTRFYGQETLKNME
                     EAEKFVDFFSKNYNEKRGIRWGIERKGASGIIGTIGFNAWSPKHKRAEIGYEIHPEQWR
                     KGYTSEAVSKVLSYGFAHMGLTRIGAVVFIENVASNKLLEKAGFQKEGVLRDYMYQGGK
                     AYDTNVYSLLRK"
     gene            complement(6400..6849)
                     /locus_tag="NP440_RS04855"
                     /old_locus_tag="NP440_04855"
     CDS             complement(6400..6849)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010094747.1"
                     /locus_tag="NP440_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04855"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_193063969.1"
                     /transl_table=11
                     /translation="MKIDDIDKKIINELYNNSRLSMSELGRKVNLSSPSVTERVRQMDS
                     FGIIKKYTLEVDYEKLGMPIQCLIEASVKNNDYKPFKNYVEKLPNVEFCYRISGSACYM
                     LKMQFETFADAEKFIDDVSPIAQTTTHFIFSQIPINLNFNMESRT"
     gene            6971..7387
                     /locus_tag="NP440_RS04860"
                     /old_locus_tag="NP440_04860"
     CDS             6971..7387
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010896602.1"
                     /locus_tag="NP440_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04860"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_193063968.1"
                     /transl_table=11
                     /translation="MARIDESNFGKTPFQKLLGHNKDVMEGWGHLGDLLERDKTLTSKL
                     KEQVRRTLAQNNGCAYCKAKGKPDLVKFDEKTSIAVGFAEVFLKQKGDIADSTFDVLRE
                     HFTEEEISELCAFISFTTASQYFGAMMKLEPDSQ"
     misc_feature    complement(7524..7537)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.69"
                     /tool="antismash"
     tRNA            complement(7724..7796)
                     /anticodon=(pos:complement(973969..973971),aa:Ala,seq:ggc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="NP440_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="NP440_04865"
                     /product="tRNA-Ala"
     gene            complement(7724..7796)
                     /locus_tag="NP440_RS04865"
                     /old_locus_tag="NP440_04865"
     gene            8652..9839
                     /locus_tag="NP440_RS04870"
                     /old_locus_tag="NP440_04870"
     CDS             8652..9839
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017798569.1"
                     /locus_tag="NP440_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04870"
                     /product="DUF4317 domain-containing protein"
                     /protein_id="WP_042532137.1"
                     /transl_table=11
                     /translation="MNKKDIADIKKQFKVNNDLLKIQDIFNVYIMKESSEIYHYESTPF
                     EMLEDEQKDLFMANFKKVLTGQLDQKLFELKFQRDVEDSSQLILHKGMLSNDTGEWKEQ
                     MLELVAKMLKDKQYEMDIVITFIHGEYAKPTKRSNEESEESSRDRVYSSPFILCSINKT
                     MDPKKELLFDYVEKEFKYHFVVDPVINLKQPIGGFLFPAFTGGAADVNHVLYSASKPYE
                     LDYHFIEEVLNAEEAMTAEDDKIVFEEIVKDVAGEQINTTTLANVYDEIQRVVEENEEP
                     DAPMLDYKDVEKVLTSSGVQDIDPDKVESAFKKVIDDEKYELKATSVVPKYTSKSIKIK
                     TKVADLKVCPQDLRYLRQTTLDGKLCLMIEVEENTVIEGFEMIPEAIFNRVEDEE"
     gene            10001..10435
                     /locus_tag="NP440_RS04875"
                     /old_locus_tag="NP440_04875"
     CDS             10001..10435
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000555786.1"
                     /locus_tag="NP440_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04875"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_256705735.1"
                     /sec_met_domain="Autoind_synth (E-value: 6.9e-05, bitscore:
                     20.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYKIVTEEQDLQKVFEIRKEIFVKEQEVSEDEEFDAFDSLDADC
                     NHILVYYDNKPVGTGRVRAVEEVGKLERICILKPYRKYGLGKVIVQSLEEIVLQKRLTR
                     AKLHGQTHAEGFYHKLGYETVSDEFLEDGIPHYLMVKQFN"
     gene            10474..11850
                     /locus_tag="NP440_RS04880"
                     /old_locus_tag="NP440_04880"
     CDS             10474..11850
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0009410 - response to xenobiotic stimulus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020007669.1"
                     /locus_tag="NP440_RS04880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04880"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_256705736.1"
                     /transl_table=11
                     /translation="MQPKLENKGVIIVTLATGFLLTFCQFLLITSYPAIMREFQINATE
                     VQWLTTIYLLTTIVFIPLTGYLSNRFSTKALLVFALLCMAAGLIVGAFSQSFIQLILAR
                     AIQAVGTGVILPVIQTILITVFPKERRGFALGLLGGVINVAPASAPSLTGMIIDVFHWR
                     ILHWFMLPLVLILLLLAVFYMKDVLKKQAARLDILSVILSAGAFSLFIFSISNISVAGM
                     DLYLVILPFCISAVFLYLFIQRQLADDVPVLNVRLFQNRTFLLAVVLIFMDMMLLLSAE
                     TILPMFAQNVLETSAFLSGFLLVPGTILLCIVSVISGNLYDRYGGRILAVIGFAFTLVS
                     LVLMTMLSIDSSPFLIMIYFCFFMTGFGLSLMPLVSVSVNVLDEKEMAHNSAIVNTVRQ
                     LGMAFGVVILTTVISVTTAVMDAPERTGTYWGTTYAFMMMAVTALLGVLLSMRIKEKIE
                     "
     gene            11949..12947
                     /locus_tag="NP440_RS04885"
                     /old_locus_tag="NP440_04885"
     CDS             11949..12947
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016201554.1"
                     /locus_tag="NP440_RS04885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04885"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_256705737.1"
                     /transl_table=11
                     /translation="MKLSVLDQSPISMGETSEAALQHTLELAKWTEELGYHRYWVAEHH
                     NTNGLSISAPEIVMTRIASVTSRIRVGSGGILLPQYSAYKVAEIGKTLATFFPDRIDLG
                     IGNSPGGSPQTRAALTDNQNRSLAEFPRQAADLQGFLHNSLPRDHDFRLVKATPRVNQV
                     PPLWILGLSARSANYAAELGTGFIFGHFINPEKGVKALQTYQENFTPSVSMENPQSIVC
                     IFIVCAETEEEAEEHALTQDKWLLNVSKGLGTKVTSSEAVHRDMDKLSAEDREIIQKNR
                     ERCIIGTPETVKQQLLELQEKYQTDEFMVINNTFDFEAKKKSYRLLAEAML"
     gene            13091..13363
                     /locus_tag="NP440_RS04890"
                     /old_locus_tag="NP440_04890"
     CDS             13091..13363
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011064904.1"
                     /locus_tag="NP440_RS04890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04890"
                     /product="YhdT family protein"
                     /protein_id="WP_042532144.1"
                     /transl_table=11
                     /translation="MKRKEWTDKRYKTANREAWTGVALVIFNFIWWFGFAYGLGSKSPE
                     SYQYIFGFPAWFFFSCILGFVVMMLLTVFVVKFFFKDMSLEAEEE"
     gene            13403..14836
                     /gene="panF"
                     /locus_tag="NP440_RS04895"
                     /old_locus_tag="NP440_04895"
     CDS             13403..14836
                     /GO_function="GO:0015498 - pantothenate:sodium symporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015887 - pantothenate transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007083432.1"
                     /locus_tag="NP440_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04895"
                     /product="sodium/pantothenate symporter"
                     /protein_id="WP_256705738.1"
                     /transl_table=11
                     /translation="MNWEAVLPLFIFIAIIFMIGIWAGKFVSRSDSFLQEYFLGGRSLG
                     GFILAMTLVTTYGSASSFLSGPGTAYNEGLGWVLLSMTQLATGYFVLMVLGKRFAIVTR
                     KYKAVTIVDFLKERYQSKWVVILSAASILIFLFSAMSAQWIGGARLVQSLTGIPYFTAL
                     CIFSIAVLVYVAVGGFRAVAITDGIQGIIMFIGTLILLIAVIIAGGGLSQIMHDLSVEN
                     PNLITPFGADGSLTPAYVSSFWILVGVGVVALPQIAVRAMSYKNTKALHRGIIISTFVV
                     GFIMLNMHLIGVFGRTVLPGIEIGDTVMPELAQAVLPGWVAGIVLAAPMAAIMTTVNSL
                     LLMVSSTIVKDVYLNYIRPDANDKTIRKWSMGATALIGIIVVLMSLQPPDLIIWLNLFS
                     MGGLEAAFIWPIILGLYWRRGTKHGAIASILTGVLSYIIFETFYPQPFGMHSVVTSMLL
                     ALIAFVSGSLLYEKEAISS"
     gene            14941..15405
                     /locus_tag="NP440_RS04900"
                     /old_locus_tag="NP440_04900"
     CDS             14941..15405
                     /GO_function="GO:0043169 - cation binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018932312.1"
                     /locus_tag="NP440_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04900"
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_042532148.1"
                     /transl_table=11
                     /translation="MKKQRHDALKPLSHHHHHALVQAMELKQAGTEKTDKSLGESIRGL
                     IDYWEKDAVLHFRDEEEVLLPLYEVYAEKTEIELMKEMLYQHMQIRSFVYAIRENREAP
                     YEKMNQLGELLEKNVRFEEREIFPVIEEAVPGKYLHQVYGKFHRDSYSGF"
     gene            15628..15963
                     /locus_tag="NP440_RS04905"
                     /old_locus_tag="NP440_04905"
     CDS             15628..15963
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036614.4"
                     /locus_tag="NP440_RS04905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04905"
                     /product="DUF5362 family protein"
                     /protein_id="WP_193063964.1"
                     /transl_table=11
                     /translation="MDYLNIDHLKRIATWGKIVGAASIIMGAISIVLTLTVDPSMILSG
                     IISIITGYLFYQTGVEASNIIASDDFTAGNVNELLNKYGKLLLIMGILTIISLVVLIPL
                     IIVLISL"
     gene            complement(16030..18003)
                     /locus_tag="NP440_RS04910"
                     /old_locus_tag="NP440_04910"
     CDS             complement(16030..18003)
                     /EC_number="6.2.1.16"
                     /GO_function="GO:0030729 - acetoacetate-CoA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (103-530). E-value: 9.9e-51.
                     Score: 164.5. Matches aSDomain:
                     nrpspksdomains_NP440_RS04910_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017795585.1"
                     /locus_tag="NP440_RS04910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04910"
                     /product="acetoacetate--CoA ligase"
                     /protein_id="WP_256705739.1"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-53, bitscore:
                     179.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTQEGTLLFEPSKTQVEQANITSYRTWLQEYKHIQTKDYYHLWK
                     WSVEDLDTFWESIWEYFNIQSHQPYQTVRSGNQIIGTKWFPEASLNYTEHVFRNKTLTS
                     PAIIHTSENRELQEISWEKLYQDTAALQKTLEKQGIEKGDRVACYAPNIYETVVAFLAT
                     ASLGAIWSSASPDFGTQSVMERFQQIEPKAMITVDGYTYNGKKFNRLDVVKELQSALPS
                     LKTTITIPYLNKQADFGDCIQPISWDIATAHQEKLEISYTPVAFNDPLWILYSSGTTGK
                     PKPIVHSQGGILLEHLKALHLHLDLSPGSRFFWFTTTGWMMWNFLVGGLLTGSTIILYD
                     GSPAYPDKQVLWRLAERTKMNVFGTSASFITACMNDNVSPKSEFDLSSLRNISSTGSPL
                     SPEGFRWCYTHVKNDIWVASASGGTDVCTAFLLGCPIQPVYAGEIQCAGLGAKIESFNE
                     DGNSITNEIGELVLTAPFPSMPIYFWNDDSGLRMYHSYFDTFPGVWCHGDYIKLTNRNT
                     AIIYGRSDATINRGGIRIGTSEIYRVTDYVTAVEDSLMVDLPKGNGDSITPLFIVMKDG
                     EALSETIKQEINQQLRTHCSPRHVPTHIYEVKELPKTLNGKKVEIPVKKILMGQDAEAV
                     INRGSLINPDSLDYFIDLAKNI"
     aSDomain        complement(16414..17694)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NP440_RS04910_AMP-binding.1"
                     /evalue="9.90E-51"
                     /label="NP440_RS04910_AMP-binding.1"
                     /locus_tag="NP440_RS04910"
                     /protein_end="530"
                     /protein_start="103"
                     /score="164.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SPAIIHTSENRELQEISWEKLYQDTAALQKTLEKQGIEKGDRVAC
                     YAPNIYETVVAFLATASLGAIWSSASPDFGTQSVMERFQQIEPKAMITVDGYTYNGKKF
                     NRLDVVKELQSALPSLKTTITIPYLNKQADFGDCIQPISWDIATAHQEKLEISYTPVAF
                     NDPLWILYSSGTTGKPKPIVHSQGGILLEHLKALHLHLDLSPGSRFFWFTTTGWMMWNF
                     LVGGLLTGSTIILYDGSPAYPDKQVLWRLAERTKMNVFGTSASFITACMNDNVSPKSEF
                     DLSSLRNISSTGSPLSPEGFRWCYTHVKNDIWVASASGGTDVCTAFLLGCPIQPVYAGE
                     IQCAGLGAKIESFNEDGNSITNEIGELVLTAPFPSMPIYFWNDDSGLRMYHSYFDTFPG
                     VWCHGDYIKLTNRNTAIIYGRSDATINR"
     CDS_motif       complement(17140..17190)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NP440_RS04910_0001"
                     /evalue="1.30E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="NP440_RS04910"
                     /protein_end="288"
                     /protein_start="271"
                     /score="14.9"
                     /tool="antismash"
                     /translation="ILYSSGTTGKPKPIVHS"
     misc_feature    complement(18011..18020)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.31"
                     /tool="antismash"
     misc_feature    18046..18057
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.78"
                     /tool="antismash"
     gene            complement(18255..19403)
                     /locus_tag="NP440_RS04915"
                     /old_locus_tag="NP440_04915"
     CDS             complement(18255..19403)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008591220.1"
                     /locus_tag="NP440_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04915"
                     /product="conserved virulence factor C family protein"
                     /protein_id="WP_193063962.1"
                     /transl_table=11
                     /translation="MKIVSIEPTPSPHSMKINVNETLPPDETYNYSNKDDLAQAPEYVQ
                     KLFALDGVKNIYRVVDFIALARNPKTPWEELLPKVRNVLGTNEAFNQTDELSADAEAPS
                     ETFGEVHVFIQTFLGIPIQVKLEEGDKEERYGLPERFSKAVMEASPASENVFMDRKWEE
                     QHPRYGNMDEIGQDVIEELKASYNQERLDTLVKLALQTDGNTSKATNYYQHVPIEKLDN
                     PDWRERYAALDRLDPTLDDLALLEKAIHDEKASIRRLATAYLGMLEDKAALPLLYEALA
                     DKAVNVRRTAGDCISDLGFTEAIPNMIETLKDKSRIVRWRGAMYLYEAGDESAIPALEE
                     ASAEEPEFEVRMQIQLALERIQGGEKAKGSVWHQMTQAAKSK"
     gene            complement(19416..19946)
                     /locus_tag="NP440_RS04920"
                     /old_locus_tag="NP440_04920"
     CDS             complement(19416..19946)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012369910.1"
                     /locus_tag="NP440_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NP440_04920"
                     /product="type 1 glutamine amidotransferase
                     domain-containing protein"
                     /protein_id="WP_193063961.1"
                     /transl_table=11
                     /translation="MRLQNQKVIALVDHDFEDLELWYPVHRLREEGAQVDLVGQAANQK
                     YIGKYGVPAESDYAFSEVNPEDYDAILVPGGWAPDKLRRFPEVIRFVQHMNEQKKPIGQ
                     ICHAGWVLISANILEGKTVTSTPGIKDDMTNAGATWVDEPAVSDGHLVSSRRPPDLPDY
                     LRELIKVMEEYQR"
     misc_feature    complement(20280..20294)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 19.13"
                     /tool="antismash"
ORIGIN
        1 aaaagaagcg gaacgctgct taggcagacg aaatgcttgt tcttcgattt ctcttgtgaa
       61 cgattttttt agcatgttcg aaatcaagac ataaattaat aggccgataa atgcatacct
      121 gagaaaatcg ctctcaatgt agactgcaag cacgccgcct attaaagaac ctattgcaat
      181 atatcctgct aatcgtttaa agacagacca tgtcacattg ccttttttgg catggttata
      241 tgttgaatta aatgaattta taatcataac cgctaatgat gtaccaatcg cagtatgcat
      301 taaatactcg cttggaatgg aatcgggtaa aaatgcaaat aagattggta ctacgacgat
      361 tccgcctcca aaaccaaaca tgcttgatag cacaccaatt aaaataccga ttaatgaaaa
      421 cattaaaaat gaaaatccca ctaacaatca tctctcttta cttatattca tttggattat
      481 ttcttagatt ctattaaatc acaaattgaa tggtgttacc ataaggcatt gtgttgtctg
      541 accagttcaa acttcaccgg ctatttgtgc ttttgtattt ttgtccgtgt tcgatagcgc
      601 aagagaaagg atgatgaata cgtagaaaat aacaaactaa ccacttgtac tctatgcaaa
      661 tcagcaattc atgcctgata aaggggcaag gaatccttct gcactcatcc ctcccgattt
      721 ttcataattg gaatgcctgt gttaatattt agtattagag agcaatgttc atccttgctg
      781 acacgttatt aaactatcaa ttaacatgcg ccaattcact cttttgtaaa gctgtattat
      841 cggagaaagg aagtttttaa atgaaaaata atactaaatt tttaatgggc atgttagcat
      901 ttgtatttgt tatattgact gcttgtggaa atgtaacaga ggattcggat gcggagtcca
      961 atcgcctgtc atcagataat gatgtgatgc aaaacgaaaa tgacaattta cctggacaag
     1021 aaagtacaca agattcatct cctatcgacc cagaaacaga aaccgattct ttttcagatt
     1081 ggaaaggaaa aagccaagat gaatcagcgg aggaacagag ccaggaagag cctttggaag
     1141 aatatgttcc caatgaagat gatgttgtat acaaaaataa tgagttgaaa aataaagata
     1201 tccttgaagc gtttatggag actgcgggag aaaatggaca ggataatgaa agtgaaatca
     1261 gagtggtgaa ggacgaaggg actcaaggtg tacttatata tgatttgaaa tccggatatg
     1321 aagaaagtgt tgatcaggca tggattatgg tttattcaga tttgagccac tacagagcct
     1381 cagatgatga agtgcaggat gtttttaata cgaatcagca atgcggatat atgtcaaaag
     1441 atgaaataga aggaaagtat aaattacatg aatgtagaac ccattgggaa tacaggttac
     1501 ttcccactgg agaagataat gaaatggagt gactgttgct tcattatctc ctctcaacaa
     1561 aaaggccgaa gcatgttagc ttcggccttt ttgttgagag aatggattgt atacttgatg
     1621 cgcacgcttg aattttttag cttataatac ttcctgtgtc tatttattta tgcttcccaa
     1681 aactccttgg tgaacaaaaa ttgtatatca tccagtaagg ttaatttaat ggtctttcaa
     1741 ttatcggagg ttattgttga agaacttaag cctaattctt tatttgaaat acgaaggaga
     1801 caggtttttt gaactttttt tcaacttgtt atgagtataa tacaggtaaa taaattaaat
     1861 aactgatttt tttgattttt cgatactatt atcttgacag ccctaaagat agcatgtaga
     1921 ttttaagtaa agggagggat gaaagatgat caattatgac aaagcaaaga aaaagataga
     1981 caaaagaaaa gaaatgcgga ctcaagaaat ctccgaaatg attgacgaag gcggtttagg
     2041 agctgataga tattatgatg ttataaaagg ctcttccccg actgagaaag aaataaaatc
     2101 aacgaaaaaa taccaaaaat gataaaacga aactttactc agtgggagtt tttcgatgta
     2161 caactcttta cgatcggacg aataaccaca gtcccacaac cctagaacgt cgctaactta
     2221 atctgtttcc ttcatactcc cactgcatta gccctaagtg attcagggag ttagctcacc
     2281 tgaacttccg cctaaataaa gtttctttta cggacgattc tctgtgataa agaagattaa
     2341 aaaagagaaa aaaaggtcac ttacattata accccgaatt attcatacct gtagattaga
     2401 gatacaaacg aaaatttgta gtttatgatt tctattttaa gcgaaaaaag ctaaaatatc
     2461 gtaggaagct ggaggtaaat agtattcaca agaaaaaaca accgtttttg gacagatcta
     2521 tcccttggtc ttccaaggaa taaaaagttt ctttttacaa tcactccaac tgaagctata
     2581 gtaaagaggt atttgaatgc aagtcaaagc aattcaaaaa cgagacaagc ttggctgaga
     2641 agcaagtgca tcttttccca tgatttgcgt aaatacccga tggtgcatca ggacatctgc
     2701 tgcatcctct tctgcatatc cagcgatgat ttgatagatt ttttgacgaa gtaaatcttc
     2761 attcgcatac atgtagcagc gccgttcatt ggtaagctgt aaatattatt ctgccaaggc
     2821 cgcagagaat ccgatttttt catccaattc acggaaaatc atttcaccag tatcagagga
     2881 taattcgcct ccatcaagag atagttttat tttatgatta aaatcaagtg tgatttgcgg
     2941 taaagcagcc attattagaa ccctttctat tggttatttg ctggctcttt taaccttaat
     3001 agaaacgggt tctttttcat ttatttgaag cagcttataa ctgtcacaat tacttgggag
     3061 gtatgagata acaagctatt tagttttttt gaatcgttga ttgttttcga acttcataaa
     3121 aatcctgtca acgccatgtt ctgtaaatga cgtatggaag aaagcatctt ttgcaggaag
     3181 attgtatcat ttccgaatcc cgcaacgtct ttctatcata aaataacatc aggggtttca
     3241 ggcaaaattt gtccgccatc tataacaagt gactgaccgg taatatattt tgcttcttct
     3301 gatgcaaaga aggaaactgt tgttccgatg tcttctggat ttcctaatcg tttcattgga
     3361 acagcttccg cacctttttc acttaacacg cccagctcct ttttcaaggt ttcagtagca
     3421 atcattccag gttgaactgc attaaccgta acgccatatg gtgcatactc cagagccgca
     3481 ttacgcataa atccaagaat tccagctttg gttgccccat aaatcgaacc gcctggatat
     3541 ccggtgatat ctcccgtaat tgacgatgtc aggatgaccc ggccgtagtt ttgcttcttc
     3601 atcgcttcta ataccggttt ggcagtgaag aacattcctt tcaaattaat gctttgaatt
     3661 ttatcccaat cttcttctgt catgtctgca atggatacat ccgggtagat acctgtattc
     3721 gcagccagaa tatcgattct ttcatgtttt tttaaaatat cctgaacaac cctttccgca
     3781 ttatttttgt ccgtcacgtc taatttatga aattcaccac tcacttctgc agccactttc
     3841 ttccctgctt cttcatcgat gtcacagatc ataacggttg ctccagcttt tgctaacgtc
     3901 ttcacaattc ctttaccaat cccatttgct ccaccggtga ccatagcgat tctacgagtt
     3961 aaatcaaaca ttatatccct gcctttcaga attcagcatt atttatactt ataggttatc
     4021 aagaaacatc gaaaaactcc atgtttgtgc atacaatact agcctataac acatttgata
     4081 tggaacataa aaaccctttt attcctagga tgtcaaacta atgaggatta cttaactgct
     4141 ctccaattgc tttatatttc aaattatttg attctcttat ccactagcaa ataacaccca
     4201 ctaatcatca gatgctgagc ttacataaat taagtagttc agtgtaaact gaatgttata
     4261 gaattaattg aaaaggattc ttaaacgggg gagtataact ggttataaaa tattaaattt
     4321 agggggaatg agcatgagac aattagaagc aatcttttta gatcgtgatg gaacaattgg
     4381 cggggatgac acggttcatt atcaggtgaa tttgaactct ttctatacgt agagaaggaa
     4441 atcaagagat taaaacaaga taatataaaa attttttcgt ttacaaatca acccggaatt
     4501 tcaaatggtt tagccaaaag acaggatttc gtacaggaat taaaagattt cggtttcgat
     4561 gatgtatata tatgcccgca tagacatgac gaagggtgtt cctgcagaaa gccaaataca
     4621 ggtatgttaa tcgaagcaca gcaaaaacac gaattgaagc ttgaaaactg tgtcgttgta
     4681 ggagaccgat ggagtgatat agttgccgca gcaaaggtgg gaagtattaa aatccttgtt
     4741 aaaactgggg caggggagtc ttccctaaat gagcattttg ataaattaaa tgatgtaaac
     4801 attgattaca tagctaatga ttttaaagac gctataagtt ggttgtatcg taattatatt
     4861 ttaagcaata gattatgaag tttatttcat aaaagggcat gattgtttaa caatgataag
     4921 tagtaaatgt ccaacttttt cacaaaaagg aatctacaaa aaagagcttc ctaaaagtta
     4981 aaattgtatc tactgcacat aaagttatca tttctcaaca gcttttgtag tatggagtat
     5041 agggtttata taattgctaa ttacgggcaa attctagatt aagaaacgaa attaaataaa
     5101 aggagagatt aaatgtttcc tgtattagag acagaaaggc tggaattacg agaattaata
     5161 aaggaagatg caaaaggcat ttttgcttgt ttttcaaatg ataaggtaac acgtttttat
     5221 ggacaggaaa cattgaaaaa catggaagag gcagaaaaat tcgtggactt cttctcaaaa
     5281 aactataatg aaaaaagagg catccgatgg ggaattgaac ggaaaggagc ttccggtata
     5341 attggaacga ttggctttaa tgcctggtct ccaaaacata aacgggctga aattggttac
     5401 gaaattcacc cggaacaatg gagaaaagga tatacttcag aagctgtatc taaagttctt
     5461 tcatatggat ttgctcatat gggtttaact cgtataggtg ctgttgtatt tattgaaaat
     5521 gtagcatcaa ataaattatt agaaaaggca ggctttcaaa aagagggagt tttaagagat
     5581 tatatgtatc aaggtggaaa agcatacgat acaaatgttt attctcttct taggaagtaa
     5641 tcttctggga tagaatgcaa taccttaata aagaccggcg tttaacgttg aagaaaaaga
     5701 gtaattagtg gaataaggat gattgaacta accaacaggt gtatgcgaat aagtaagaga
     5761 gcaggcggtt tgattgtttc ggttcacagt gtttttagtg catgtattct tatttttatt
     5821 agctactgtt attggggtgt atggtaaata taacccctct gcccgtgtat cagataaatc
     5881 ctatggagtt tggttttcag ctatcgtcat ttttaatgta cttgtcatag tctctgcttt
     5941 tgtgcagttg agggtaagaa aaatatggtt atttttaata gcggtgatag gtttaatttt
     6001 tttttttaat ctacttttta ccacagattg tgctttattt ggagagttta ttttaaagtg
     6061 gatattgatt ttccagaatc gggattgatt gtaaaacaaa cagggtaaca tgtaagaaat
     6121 aaaaaattgt tattattttg attttggaag ttagagaaca aatatttttt caattactaa
     6181 ataattaaat gtatgaataa agtagtgcat taaaaaaaca cgcttctcat tctgaattag
     6241 aataagtaag cgtgttttag tgtataaccc aatgatggag cttacgggaa ttgaacccgc
     6301 tatctccttc tgccgaaaaa atggagattt actatctttt aaaataattg gtattcagat
     6361 taacctgtag aacgtgagag tttggtttaa gaattttaat tatgtgcgac tctccatatt
     6421 aaaatttaaa tttataggaa tttgtgaaaa gataaaatgt gttgtagttt gtgcgattgg
     6481 acttacatca tcaatgaatt tttctgcatc agcaaacgtt tcaaactgca ttttaagcat
     6541 atagcacgca cttcctgata tgcgataaca aaattctacg tttggaagtt tttctacgta
     6601 attcttaaaa ggtttatagt cattattttt aacggatgct tcaatgaggc actggattgg
     6661 catacctaat ttttcataat caacttctaa agtatatttc tttataatac caaatgaatc
     6721 catctgtctt actcgttctg ttacggatgg agaggacaag tttacctttc tccctagttc
     6781 actcattgac aagcgactat tattatatag ttcatttata atttttttgt caatatcatc
     6841 tattttcatt tttaaagttt tcctcctaaa atcatttatt ttgaaagaaa tttatatgaa
     6901 cttgtttatg aaattaatgt gattaattta ttttatttta tataattaaa tataacaagg
     6961 agggctaatc atggcaagaa ttgatgaatc taattttggt aaaacacctt ttcaaaaact
     7021 attgggacat aataaagatg taatggaggg atgggggcat ttaggtgatt tattagaaag
     7081 agataaaaca ctaacttcta aattaaagga acaagtaaga agaacattag ctcaaaataa
     7141 cggatgtgcg tattgtaagg ctaaaggaaa accagatttg gttaaatttg atgaaaaaac
     7201 atctattgca gtagggtttg cagaagtttt tttaaaacaa aagggtgata tagctgattc
     7261 aacttttgat gttttacgag agcactttac tgaagaggaa ataagtgaat tatgtgcgtt
     7321 tatttctttt acaacggctt cacaatattt tggtgcaatg atgaaattgg aacctgacag
     7381 ccaatagtgc agtaagtagg cgcatttgtg aaacaaacag gggaattata aataaagtgc
     7441 tttcctgttt tgattttagt agttggagaa tatcttctta cactattttc taatacccta
     7501 aataattata tttacgaaga aaaatttatt aaaaaatact cttcttaatt ctaattaaga
     7561 agagtatttt ttcagggtat ggttggaacc cgtgacccct tgtctgccag acaagtattc
     7621 tcccaaatga ctttatttca ctaccataaa aaaaatgagg ctctacaacc taaaaaaaac
     7681 tcttctactt ctaaaattag aataagcaag agtgcttttt aaatggagct gacggggctc
     7741 gaacccgtga ccttttgtct gccagacaaa tattctccca actgaactac agccccgtta
     7801 ttaaatgtaa gataaatgaa taatatctgg aacaatcata ttatatactt ttcgctaaat
     7861 tgtatcaaga tttttgttat acattcagat taaatgattt tgcctggaaa taataaaaag
     7921 aagaattcca ttgtttaatg aaatgatata ataaataaaa agtaatcaaa gggagcaatt
     7981 ggcatgcaac acgccaatct ggagaagatt aaagagggag gctttgtgta ttgtatggag
     8041 aatgatgtta tttttaataa ggttgcgatt atgaaagatg tcttatccgc gtgaaaaaag
     8101 tttataatga taatacagag aatttaaaag ttttcataaa gcaggactcc attaattaaa
     8161 atatttaaag ggcttgtgaa gcagctctcc agctggcaat gcacattgtt tctgaggaaa
     8221 gattaaggtt gccgtaaacg agtgaggata ttttagttag gttacaggaa tatgacataa
     8281 ttagtcaaag aacagagacg cggctaagag ggataatgga atttaaaaat attgcaatac
     8341 gagattatcc atcgtggaat cttgataggg tgaaatcaat aaaaaatcac ttagacgacc
     8401 ttactgctta taaaaaagaa attctaaact atcaacatag aaagtaacca taaaaaatac
     8461 aagtaaataa agaaatccaa atgaaagagc tttctgttat cagaaggctt atttatttgt
     8521 tatttttgct tctgaaaatc ttaaatgaat gaaagaacaa cctcctattg atttgtgata
     8581 aaatagatag acgctgttga aagctggcag caaaagtgat aagccgatta agaaacagag
     8641 gagaatccaa tttgaataaa aaagatattg ccgatataaa aaaacaattc aaagtaaata
     8701 atgatttatt aaagatacag gatattttca atgtatatat catgaaagaa tcgagtgaaa
     8761 tctatcatta tgaaagtacg ccgtttgaaa tgctggagga tgaacagaaa gatttattta
     8821 tggcgaattt taagaaggtg ctgacggggc agctggatca aaaattgttt gaattgaaat
     8881 tccagcgtga tgtggaagac agcagccagc ttattcttca caagggaatg ctctcaaatg
     8941 atactgggga atggaaggag cagatgctcg agctggtagc aaaaatgctg aaggataaac
     9001 agtatgaaat ggatattgtt attacgttta tccatggaga gtatgcaaag cctacgaagc
     9061 ggagtaatga agaatcggag gaaagcagca gggacagagt gtattccagt ccatttatct
     9121 tatgcagcat caacaaaaca atggacccga aaaaagaact gctttttgat tatgtggaga
     9181 aggaatttaa atatcatttt gtggtggatc cggtgattaa tttaaaacag cctatcggcg
     9241 ggttcttatt ccctgctttt accggcgggg ctgcggatgt gaaccatgtt ctttattccg
     9301 cttcgaaacc gtatgagctc gattatcact ttattgagga agtgctgaac gcggaggaag
     9361 caatgaccgc agaggacgat aaaatcgtgt ttgaggaaat tgttaaggat gtagcaggag
     9421 agcagatcaa tacgacgaca ttggcgaatg tatatgatga gattcagcgt gtggtggaag
     9481 aaaatgaaga gccggatgcg ccaatgttag attataagga tgtagagaag gtgctgacaa
     9541 gcagcggtgt acaggatatt gatccggata aagtagagtc tgcttttaaa aaggttattg
     9601 atgatgaaaa gtatgagctg aaagcaacca gtgtagttcc gaagtatacg tctaaatcca
     9661 ttaaaatcaa aacaaaagtg gctgacctta aagtatgtcc gcaggatctg cgctatcttc
     9721 gccagacaac gcttgacggt aagctttgtt taatgattga agtggaagaa aacacagtga
     9781 ttgaagggtt tgaaatgatt ccggaagcta tctttaatag agtggaagac gaggaataat
     9841 atagtaaagt ctcttagtcg aaataaggct gggaggcttt ttaagagact tagcaagctt
     9901 attatatttg ttgcatttac aacaatagtc agttatttta caatagtagc aatcatattt
     9961 tttaacagga tgcaaacaga ggcagagagg ggaaactcag gtgacttata aaatcgtaac
    10021 agaagaacag gatttacaga aggtttttga gattagaaaa gaaatcttcg taaaggagca
    10081 ggaagtgtcc gaagacgagg agtttgatgc atttgattcg ctggatgcgg actgcaatca
    10141 tattttagta tattacgata acaagcctgt aggaacagga agagtgagag cggtagaaga
    10201 agtcgggaag ctggaacgaa tttgtatttt aaagccttat cgtaagtatg ggcttggcaa
    10261 ggtaattgtg cagtctttag aagagattgt tttacaaaaa agattaaccc gcgcaaagct
    10321 gcatggtcag acgcatgcgg aaggatttta tcacaaattg ggatatgaaa cggtgtcaga
    10381 tgaattttta gaagatggta ttccgcatta tttgatggtg aagcagttta attaaagcat
    10441 tacatataac gtcacaacgg ataaggagga gccatgcagc ctaaattaga aaacaaaggg
    10501 gttattattg ttacgctggc aacaggattt ttattaacat tctgccagtt cctattgatt
    10561 acgtcttacc cggcgattat gcgggaattt cagattaatg ccacggaagt acagtggctg
    10621 acgacgattt atttattaac aaccatagta tttatcccgt tgacgggcta tttatctaac
    10681 cgattttcaa ccaaagcgct tttagtattt gcattgcttt gcatggctgc cggtcttatt
    10741 gttggcgctt tttcgcaaag ctttatccaa ttgattcttg ccagagcgat tcaggcggtt
    10801 ggaactggcg tcatattgcc cgtgattcaa acgattttaa ttaccgtatt tccgaaagaa
    10861 agaagagggt tcgcacttgg actgctgggc ggcgtcatta atgtcgctcc ggcaagtgcg
    10921 ccgtctttga ccgggatgat tattgatgtt ttccattggc gcatccttca ttggtttatg
    10981 ctgccattgg tgctgatact tttgctgtta gcggttttct atatgaagga tgtattgaaa
    11041 aaacaggcag caaggctgga tattctctct gtgattcttt cggcaggggc tttttctttg
    11101 tttattttta gtatcagtaa tattagtgtt gccggcatgg acctgtatct cgttattttg
    11161 ccattttgta tcagtgctgt ttttttatat ctttttatcc agcggcaatt agcagatgac
    11221 gtgcctgtgc tgaatgtgcg tttgtttcag aaccgcacat ttctgttggc tgtggtgctt
    11281 atatttatgg atatgatgct cttattatcg gcagagacga ttttgccgat gtttgcgcag
    11341 aacgtcttag aaacgagcgc ctttctatct ggatttttat tagtgccagg cacgattctg
    11401 ctttgtattg tctctgttat ttcgggaaat ttatatgatc ggtatggcgg aaggatttta
    11461 gctgttatcg gttttgcttt tacgcttgtg tccttagtac tgatgacaat gctaagcatc
    11521 gacagctctc catttttgat tatgatttat ttctgctttt ttatgaccgg atttggtttg
    11581 tcgctgatgc cgctagtttc tgtcagtgtc aatgtattgg atgaaaagga aatggctcat
    11641 aattcagcga ttgttaatac cgtgcgtcaa ttgggaatgg cttttggcgt ggtgattctg
    11701 acaaccgtta ttagtgtaac gactgctgtc atggatgcac cggagcggac aggaacctat
    11761 tgggggacga cgtatgcatt tatgatgatg gctgtgacgg cattgcttgg tgtgctgctg
    11821 tccatgcgga taaaggagaa aatagaatag cggagcagcg gtaaaaagca gaaatgttga
    11881 atggaagaca tttctgcttt ttaattattt gtagaagttt ttaaactgga aaaaggaacg
    11941 tgtttaacat gaaattaagt gtactagatc aatctccaat ttccatgggg gaaacgtcag
    12001 aagcggcatt acagcatacg ctggagctgg caaaatggac ggaggagctt gggtatcacc
    12061 gctattgggt ggcagagcat cataatacga atgggctgtc gatttctgct ccagaaattg
    12121 tgatgacgag aatcgcttct gttacaagcc gtattcgtgt cggctcaggc ggtattttgc
    12181 tgccgcagta cagtgcgtat aaagtcgctg agattggcaa aacattagcg acgttttttc
    12241 ctgatcgaat tgatcttggc attggaaatt cgccgggagg ttctccacag accagggctg
    12301 cgctgacaga taatcaaaat cggagtttag ctgaatttcc gagacaggct gctgatttac
    12361 aggggttttt gcataattcc ctcccgcggg accatgattt tcgtttagta aaggccactc
    12421 cgcgtgtgaa tcaggtaccg ccgctttgga tactcgggtt atccgcgcga agtgcaaact
    12481 atgcagcaga actgggaaca gggtttattt ttggccattt tatcaatccg gaaaaaggtg
    12541 tgaaggcgct ccaaacgtat caggaaaatt ttacaccatc tgtcagtatg gaaaatccgc
    12601 aatctatcgt atgtattttt atagtctgtg cagaaacaga agaagaggcg gaggagcatg
    12661 cgctgacaca ggataaatgg ttattaaatg tcagtaaagg attaggaacg aaagtaacgt
    12721 ctagcgaggc tgttcaccgt gatatggata aactgagtgc agaagataga gagataatcc
    12781 aaaagaacag ggaaagatgt attatcggta caccggaaac agtgaaacaa cagttattgg
    12841 aactgcagga gaaataccag acggacgagt ttatggtcat taataataca tttgattttg
    12901 aagcaaagaa aaaatcctat cgtctgttgg cagaagcaat gctttaaact agtaatgaaa
    12961 taataggaag tggaacaagg atttgttatg tctgtgatct aattgaaatt gctgccagtt
    13021 tacagttgat aggaatttga ttatagtaag aaagaaaata atcttttcag aatggttagg
    13081 agcttttagt atgaagagaa aagaatggac ggataaacgt tacaaaactg ccaaccggga
    13141 agcttggacc ggtgtagcgc ttgtgatttt taattttatc tggtggtttg gatttgctta
    13201 tggacttgga agcaaatctc cagaatccta tcagtacata tttggtttcc cggcttggtt
    13261 tttcttcagc tgcattcttg gatttgtcgt gatgatgctg ttaacggtat ttgttgttaa
    13321 attctttttt aaagatatgt ctttagaagc cgaagaggaa taaacaaagt atgtcttatt
    13381 ttgagatcaa gggagtttaa ccatgaattg ggaagctgtt ttaccactat ttatatttat
    13441 tgcgattatt tttatgatag gaatttgggc tggcaaattt gtcagccgct ctgattcgtt
    13501 tttacaggaa tattttctgg gcggcagaag tcttggcggc tttattttgg cgatgacact
    13561 ggtaacaacc tatggaagcg cgagcagctt cctgagcggg ccgggaacag cctataatga
    13621 agggcttggc tgggtgctgc tatcgatgac acagctggca acgggttact ttgtcttgat
    13681 ggtgctcggc aagcgttttg cgattgtcac cagaaaatat aaagccgtta caatcgttga
    13741 ttttttgaag gaaagatacc aatccaaatg ggttgtgatt ctttctgcgg ccagtatttt
    13801 gattttcctg ttttcggcga tgtcggcaca atggattggc ggggcacgtc tggttcaatc
    13861 cttgacaggg attccatatt ttacggcgtt atgtattttt tcaatagctg ttttagtata
    13921 tgttgccgtt ggcggctttc gcgcagtagc gattacagat ggtatccaag gtattattat
    13981 gtttataggt acacttattt tacttatagc cgtaattata gcaggaggcg gtttatctca
    14041 gattatgcat gatctgtctg tggagaatcc caatttgatt acaccattcg gtgcagatgg
    14101 aagtttaacc cctgcttatg tttcctcctt ctggatattg gtcggtgtcg gggttgttgc
    14161 cttaccgcag attgcggttc gtgcgatgtc ttataaaaat acaaaggcgc tgcatcgagg
    14221 cattattatt agtaccttcg tagtcggttt tattatgctg aatatgcatt taattggagt
    14281 gtttggaagg actgtacttc ccggtatcga aatcggtgat accgtgatgc cggaattagc
    14341 acaagccgtt ttaccgggct gggttgccgg aattgttcta gcagctccga tggcggcgat
    14401 tatgacgacg gttaactcgc tgctgttaat ggtaagctcg acgattgtaa aggatgttta
    14461 tctaaactat atccgtcctg atgcgaatga taagacgatt cgcaaatgga gtatgggtgc
    14521 taccgcgtta ataggaatca ttgttgtatt gatgtcactt cagccgcctg atttgattat
    14581 ctggctgaat ttattctcca tgggcgggtt ggaggctgct tttatctggc cgattatcct
    14641 cgggctttat tggagaaggg gaaccaagca tggagcaatt gcttcgatac tcaccggtgt
    14701 actcagttat attatttttg aaacatttta tccgcagccg tttgggatgc attctgtggt
    14761 gacttctatg ctgctggctt tgattgcatt tgtttcagga agcttattat atgaaaaaga
    14821 agctatatca agctgaaatc gtatatctgc agacagggtt tggtttatac tagaggagaa
    14881 gacgcttctc cctgttttta gctggagaag tttatcagac agtgtcggag gtgggttatt
    14941 gtgaaaaaac agcggcatga tgcactgaag ccattatcac atcaccatca tcatgcatta
    15001 gtacaagcaa tggaattaaa gcaggccggt acagaaaaga ccgataaatc cttaggcgaa
    15061 tccattagag gtcttattga ctattgggaa aaggatgccg tccttcattt ccgggatgag
    15121 gaagaggttc tgctgccgct ttatgaggtc tatgctgaaa aaacggaaat cgaattgatg
    15181 aaagaaatgc tttatcagca catgcaaatc cgcagtttcg tttatgcgat acgtgaaaac
    15241 agagaggccc catatgaaaa aatgaatcag cttggggagc tgttagagaa aaatgtccgg
    15301 tttgaggaga gagaaatctt tccagttatt gaagaagctg ttccaggtaa atacctgcat
    15361 caggtgtatg gaaagtttca tcgtgattcc tacagcggtt tttaaataag agaaggaatg
    15421 ctgatggaag ggagcttatc ctgccatcag catttttcta tttagagagt ttgatttgta
    15481 taacataggg caggaatcac acgttttcat ctaaaacata aagtaatcat aaaacgaatc
    15541 cataaataaa cggaactgga agaatgttta ataaatcgat taaaggtgaa tatagtaata
    15601 aagtcactat taaggagagg cgatttgatg gattatttaa atatagacca tttaaaaaga
    15661 attgcaacat gggggaaaat tgttggagcg gcatccatta tcatgggggc aatttcgatt
    15721 gttttaactt taacggttga tccgagcatg attctttctg gtattatttc tattataact
    15781 ggctatctct tttatcaaac aggcgtagag gcttctaata ttatagcttc agacgatttt
    15841 acagcaggca atgtgaatga gttattaaat aagtatggaa aattattgct gattatgggg
    15901 attttaacga ttatctcgtt agtcgtgctt attccattga ttattgtatt aatctctctt
    15961 tgatttaaaa ataaggtatt tgttgaaaaa gctgatggaa gaataacggc tatcttccat
    16021 cagctttttt tagatgttct tagctaagtc gataaaatag tcgagactat ccggattaat
    16081 cagagagcct cgattaataa cggcttctgc atcctgaccc atcaagattt tcttaacggg
    16141 aatttcgact ttctttccat ttaaagtttt tggaagttct tttacttcat aaatatgggt
    16201 cggaacatgc cttggggagc aatgtgtccg cagctgctga ttaatttcct gtttaatggt
    16261 ctcgcttaat gcttcgccgt ctttcattac aataaataag ggggtaatcg aatcgccgtt
    16321 tccttttggt aaatcaacca ttaaactgtc ttcaacagcg gtaacataat ccgtgactcg
    16381 atatatttca ctcgttccaa ttcggatgcc gccccgattg attgttgcgt ctgatctgcc
    16441 gtaaatgata gctgtatttc gatttgtcag tttgatatag tctccatggc accagacgcc
    16501 ggggaaggta tcgaaatagc tgtggtacat ccgcagcccg gagtcatcgt tccagaaata
    16561 aatcggcatg cttggaaatg gagcggtcaa gacaagctcg ccaatctcat ttgtaatcga
    16621 atttccgtct tcattaaagc tttcaatttt cgctcccagt cctgcacact gaatctctcc
    16681 ggcataaaca ggctgaatag ggcagccgag taaaaatgcg gtgcaaacat ccgtcccgcc
    16741 gcttgccgaa gcaacccaga tatcattttt gacatgtgta tagcaccatc gaaatccttc
    16801 tggagaaagc ggcgagcctg ttgaactgat atttcttaaa gaagatagat caaattcgct
    16861 tttcggcgat acattatcgt tcatacaagc tgtgataaag ctggcgcttg tgccaaatac
    16921 attcattttt gtccgctcgg caagccgcca taaaacctgt ttatccggat aagcagggct
    16981 gccgtcatac aagataatgg tagagcctgt taataatccg ccgacaagga aattccacat
    17041 catccagccg gttgtagtaa accagaagaa gcgggagccg gggcttaaat ccaagtgtag
    17101 gtggagagcc ttcaaatgct ccaatagaat accgccttga ctgtgcacaa taggcttcgg
    17161 tttgccggtt gttccagagg aatagagtat ccagagcgga tcgttaaagg caacaggtgt
    17221 atacgaaatt tccagttttt cttgatgcgc tgttgcaata tcccaggaaa tcggctgtat
    17281 acagtcaccg aaatctgcct gcttgtttaa gtaaggaata gtaatcgttg tttttaaaga
    17341 aggaagcgca gattgcagct ccttgactac atctaatcta ttaaatttct tgccgttata
    17401 cgtatagcca tcgaccgtaa tcatcgcctt tggctcgatt tgctggaaac gctccatcac
    17461 gctctgggtt ccaaagtcag gagaagcgct ggaccagata gctcctaagc ttgccgttgc
    17521 aaggaaagca accaccgttt catagatatt tggcgcatag caggctaccc tgtctccctt
    17581 ttcaattcct tgcttttcca atgttttttg aagcgcagct gtgtcttgat atagtttctc
    17641 ccaagaaatt tcctgcagct cccgattttc cgatgtatga ataatagcag ggcttgttaa
    17701 tgttttattc cggaatacat gctctgtgta attgaggctt gcttcgggaa accattttgt
    17761 tccgatgatt tgattgccgg aacgcaccgt ttgataaggc tggtgcgact ggatattgaa
    17821 atattcccaa atagattccc agaatgtatc gagatcctcc acagaccatt tccataaatg
    17881 atagtaatct ttagtctgga tatgtttata ttcttgtaac caagtacgat aagaagtaat
    17941 atttgcctgt tccacttgtg ttttacttgg ttcaaaaagc agcgtacctt cttgtgtatc
    18001 cattcgttat gtcccccttc aagtactccg atactactat tataggaaaa cgctttctat
    18061 acgtaaagga attgaaatgg aaaatatatg ttttacagca aagagaaaaa tataaaacga
    18121 tcagcagtga agcgtgtagc ttacaggaga aaagaatata tattaatgat atgtatcgtc
    18181 tgttccattt agatatgaaa aaactaatcc agagcatagc tctgaattag tttagattca
    18241 tctgtgaaag catcctattt tgattttgct gcctgcgtca tttggtgcca gacagagcct
    18301 tttgcttttt cgccgccttg aatacgctct aaagctagtt gtatttgcat gcgtacttca
    18361 aactctggtt cctcagcaga tgcttcttca agagcaggaa tagcagattc atcgcccgcc
    18421 tcatataaat acattgctcc gcgccaacgg acgatccggc ttttgtcctt taatgtttca
    18481 atcatgtttg gaatcgcctc tgtaaagccc aggtctgaaa tacagtcacc ggctgttcga
    18541 cggacattca cggctttatc agccaaagct tcatatagca atggcaaagc agctttatcc
    18601 tccagcatgc ctaaataagc agtggccaaa cgacggattg atgctttttc atcgtgaatc
    18661 gctttttcta aaagggcaag atcgtccaag gtcggatcca gacgatccag tgctgcataa
    18721 cgttcccgcc aatccgggtt atccagtttt tcaatcggaa catgctgata gtagtttgtg
    18781 gctttgcttg tatttccatc agtttgtaaa gctaatttca caagggtatc cagtctttcc
    18841 tggttataac ttgcctttaa ctcttctata acatcctgac cgatttcatc catattgccg
    18901 tagcgagggt gctgttcttc ccattttcgg tccatgaaga cattttcaga agcgggagag
    18961 gcttccatta cagctttgga aaaacgctct ggcagtccgt agcgttcctc cttatctcct
    19021 tcttccagct ttacctgtat tggaatccct aaaaatgttt gaatgaaaac atgaacttcg
    19081 ccaaatgttt ccgaaggtgc ttctgcatca gcagataatt catcggtctg gttaaaagct
    19141 tcgtttgttc ccaatacatt ccggaccttt ggcaaaagct cctcccaggg tgtcttcgga
    19201 tttcgggcca aagcaataaa atcgacgaca cgatagatgt ttttgacccc atccaaagca
    19261 aaaagcttct gcacatactc cggagcttga gctaaatcgt ccttgttact gtaattatac
    19321 gtttcgtcgg gaggaagcgt ctcgttcaca ttgattttca tagaatgcgg actcggtgtc
    19381 ggttctatag aaacaatttt catttgtata ctcccttaac gctgatattc ttccatcact
    19441 ttaatcagtt cacggagata atccggtaaa tcaggcggtc ttctgcttga aacaaggtga
    19501 ccgtccgaaa cagccggttc atcaacccat gtcgctccgg cattggtcat atcatccttg
    19561 attccaggtg tactggttac ggttttaccc tctaaaatat tggcagaaat taatacccag
    19621 ccggcatgac aaatttggcc aataggcttt ttctgctcat tcatatgctg aacgaacctg
    19681 ataacctccg ggaaacgacg caatttatct ggagcccacc cgccgggtac caggatagca
    19741 tcatagtctt ctggattcac ttcggaaaag gcataatctg attcagcagg aacaccgtat
    19801 tttccaatgt atttttgatt ggcagcttgt ccgactaaat ctacctgagc gccttcttca
    19861 cgcagacggt gaacgggata ccatagttcc agatcttcaa agtcatgatc aacaagtgcg
    19921 ataacttttt ggttttgtaa acgcaaaata atccctccat tctttataga aatagtttaa
    19981 cagactggcg taaaaataac gattccgacg acttttaacg gagctgaagc caagaaaaag
    20041 ccatcacctc ggtttaacaa ggaaatggct ttggaatacg tattatttta aagcgtcctg
    20101 tacagaaaca taatcataat ttaaatcatt ggcaactgct tcatttgtta catgcccatt
    20161 cattacattc acaccgctgg cgattggagc gctattttga atcgcatgct cgacgccttg
    20221 tttcgcaata ttgactgcat atggcacggt tacatttgtc agtccgaccg ttgcagtgcg
    20281 tggaacagct cccgggatat tggcaacagc ataatgaagg acgtcatgtt tgacatagat
    20341 tggatcttga tgtgtagtag gatggtcaac ggtttcaaag ttaccgccct ggtcaattgc
    20401 tacatccaca atgacactgc ccggctgcat cgctt
//
