LOCUS       NZ_CP076385            11368 bp    DNA     linear   CON 27-AUG-2024
DEFINITION  Streptomyces sp. G11C(2021) chromosome.
ACCESSION   NZ_CP076385
VERSION     NZ_CP076385.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. G11C(2021)
  ORGANISM  Streptomyces sp. G11C(2021)
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137224)
  AUTHORS   Undabarrena,A., Serna,N., Zamora-Leiva,L., Cumsille,A., Gonzalez,V.,
            Valencia,R., Ugalde,J., Reyes,F., Olano,C., Salas,J.A. and Camara,B.
  TITLE     Towards deciphering Streptomyces albidoflavus metabologenomics:
            insights into a new member of the tetrahydroisoquinoline family
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7137224)
  AUTHORS   Undabarrena,A., Serna,N., Zamora-Leiva,L., Cumsille,A., Gonzalez,V.,
            Valencia,R., Ugalde,J., Reyes,F., Olano,C., Salas,J.A. and Camara,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2021) Laboratorio de Microbiologia Molecular y
            Biotecnologia Ambiental, Universidad Tecnica Federico Santa Maria,
            Av. Espana 1680, Valparaiso 2340000, Chile
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024499195.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 07:37:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,192
            CDSs (total)                      :: 6,097
            Genes (coding)                    :: 5,931
            CDSs (with protein)               :: 5,931
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 166
            CDSs (without protein)            :: 166
            Pseudo Genes (ambiguous residues) :: 0 of 166
            Pseudo Genes (frameshifted)       :: 66 of 166
            Pseudo Genes (incomplete)         :: 127 of 166
            Pseudo Genes (internal stop)      :: 16 of 166
            Pseudo Genes (multiple problems)  :: 38 of 166
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:57:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6687132
            Orig. end                         :: 6698500
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP076385.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="24"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            272..1327
                     /locus_tag="KNZ81_RS29835"
                     /old_locus_tag="KNZ81_29545"
     CDS             272..1327
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894130.1"
                     /locus_tag="KNZ81_RS29835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29545"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_215221578.1"
                     /transl_table=11
                     /translation="MSAARTAAPVLRRGWTGTGVKAAVLVVLALAAGVAGLVAGPAVTT
                     ADVAEVLAGGGDPLARHIVLNLRLPRALVAVTAGACLALAGLVLQSALRNPLAGPEVTG
                     VTPGAVLGAVTATGLGLAGWQSPTAVVVAACLGGCAGAGLLWLLAGRERGDPEQTAVHG
                     VLVSAVLTGATAVVLLIAPGELGSVVQWLVGSTEGRVWRHWELLWPWALCWGAVAWLLA
                     GPLTLLRCGDEQAAALGLDTGRARAAALACAVALTAGAVSAVGALGFVGLLVPHVALAV
                     FGADLRATLPGAALLGAVVVGGADAGAQLLSRALAQALDADRLTVPVGALTTCAGAALL
                     LIVARRRADLR"
     misc_feature    1391..1406
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            1449..2285
                     /locus_tag="KNZ81_RS29840"
                     /old_locus_tag="KNZ81_29550"
     CDS             1449..2285
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="KNZ81_RS29840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29550"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_215221579.1"
                     /transl_table=11
                     /translation="MDHREPGAVVAEGLRFGYPGREVLRGVDLRIGAGELVALVGLNGC
                     GKSTFLRLAAGLLRPDGGRVLLDGEEVARLSRRGAARRVALLHQSAPPVPGLTVRQLVR
                     QGRYAARGPLGMLRDGDDAVSARALADAGVADWAGRPVDALSGGERQRVRLAMALAQDT
                     RTLLLDEPTTYLDLRHQLEVLQTVVRLRAERDLTVVMVVHDLNHAARFADRIVALRDGR
                     VAADGKPADIVTPALLAEVLGVEGRVAPDERGGWPVCYPDHPLEAARHLRNENHIH"
     gene            2354..2488
                     /gene="amiA"
                     /locus_tag="KNZ81_RS29845"
     CDS             2354..2488
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="KNZ81_RS29845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_023420772.1"
                     /transl_table=11
                     /translation="MEHDKVFAPIADPGQLAHLSATHSNALVENPFDDADETGAADDK"
     gene            2633..3478
                     /locus_tag="KNZ81_RS29850"
                     /old_locus_tag="KNZ81_29555"
     CDS             2633..3478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470988.1"
                     /locus_tag="KNZ81_RS29850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29555"
                     /product="hypothetical protein"
                     /protein_id="WP_033948939.1"
                     /transl_table=11
                     /translation="MTSSRLAPGAGIVTVPGGRPAVRTAEGEFLHLDTGAADLAALTRR
                     LVSGEAASDAEVARVAAAFEREGHAVRPAPEEGGRLTGRTVLLLGDARLTGPLARYATA
                     EGALARHATPEHVARLADGEGADASTAVVWCLDEPVPPGLWDVADRLPAHGTAWLRCHR
                     EGAHLWTEPLAAAPGDVTSAHVRLRRLAATSAHRQLAAYWAGHRTPDNGPHPGEAAAAL
                     VAALLTADLLAWAVPGPNSGLPARRRLRRVDLRDLTVTEHPVLPVPPVAPLPGRGSGPA
                     "
     gene            3475..5004
                     /locus_tag="KNZ81_RS29855"
                     /old_locus_tag="KNZ81_29560"
     CDS             3475..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639446.1"
                     /locus_tag="KNZ81_RS29855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29560"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_215222499.1"
                     /transl_table=11
                     /translation="MTPATTRLTTPDGTTLATDLHLPATPGSHPAVLIRTPYDRRAHRA
                     ELRGWAERGFAAVAQDVRGRHGSAGEWHPYRDHEAEDGVATLDWIRAQPWSDGRVVAAG
                     ASYAAYCALAAALCPGAPGPDAVIAAVPALGLTETAREPTGPERLWARLGWWAAHGDRP
                     DSAPDALARTLARDPRLPEHLPLTRIADRLDRPLPSWPGLWEDCRRGRLVAHGSAARLP
                     LLAVGGTRDPFAEDTVALWRGWGGPARLLLGPWGHTLTAGTRPGTPGRLDLGALYARWA
                     RAALDGEIGPGRRGVIGLAQSGRWHHLTDSVTRPEGHEVAGAVWRFGAADGLRLLAGAE
                     FTADPDRPVRSDDLTVPRGRTPADRCLLATPPLPRPLDLAGSAEARLTVVADTPRADWA
                     VRVVALDPAGRADPLAFGIVRRDAPPGTPHPVTVPLGTLGRTLAAGTTLRVEIAGHHFP
                     AHARNPHTGEDPVTATRLAASRRTVRTEGSALHLPVAGRPRPVDPVPETCR"
     gene            5001..6368
                     /locus_tag="KNZ81_RS29860"
                     /old_locus_tag="KNZ81_29565"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="KNZ81_RS29860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29565"
                     /product="YcaO-like family protein"
                     /protein_id="WP_215222500.1"
                     /sec_met_domain="YcaO (E-value: 9.5e-44, bitscore: 148.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAALPLDALVDPHCGLVRDVAPVPHPEGAPPRYTAMTAHVADAR
                     RFGAWPADRVSLGTTFGDPAGAWTAAVAEAVERYCGNRLPPPGHPDAPRRATAAQLTAE
                     GHQVYGPDDVPAYAPWQYRRPAFPYAPLTPDTPALWARGTENGRDCWAPVALTHLNWRQ
                     GELRSLPRTHHLNYAGIATGQGLADAAERALLEVVERDALELWWHLDGPTRGIDPGSVP
                     GLDADLAGCGLEVSIVEMPSEFAPCVAALVHDARRGVHAAGFACRFDPAEAARKAVLEA
                     VHTWVFTLGAEAADGWVHQAVEAGVLARGLYLDHRADRRYLDDCGEEFAAVRDLGAHVQ
                     AWLDPRLAPLARRFTAPALGTVPVADLAHGSRDRLDTALAKGGHRVLTFDLTTEDVAET
                     ALRVARVLVGGLVPNAPAAFGYYGCPRFATAAPARGWRSQPPREPGDFTLAPAPHM"
     gene            6383..7690
                     /locus_tag="KNZ81_RS29865"
                     /old_locus_tag="KNZ81_29570"
     CDS             6383..7690
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508299.1"
                     /locus_tag="KNZ81_RS29865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29570"
                     /product="nitroreductase"
                     /protein_id="WP_215222501.1"
                     /transl_table=11
                     /translation="MTTDATLGHALALARSPRTPARATPPPRRPYPWTGTPLALPTTAP
                     DPDGPVDLDHLLRHALRARPGTGGRLRPAASAGALHPVRAHLLIGPGCTLPPGRYAYDP
                     EVHRVFRRGPAPHGAAPGVIAVLTATAERTAAHYGHRAWPLLLLDTGHAAAALALAPQG
                     PGVRVSLDADAATLAAAAGLPPADRWQRIRPGTETEHPLAAVQLTPRRTQCTTPALDRW
                     SALPLPDRTRTPTRPPARPCGTGRLLELLGAATGTEPTWHLVRRPDAVTGRALLDRRSA
                     DPAALGHPPDGGTVARILHTAATAWPGGPAWCAAVAAPTPALFAPGHRTAAPHRLARGD
                     ARPSLAHWAAGQLWLADTGAVLLAHGCPSDAPAHQVRHDHLAAGFAAGTAHAHAAAEGI
                     AARPVGSWQQADLGAALGETPGLDWVLHGLALGAAR"
     gene            7749..9494
                     /locus_tag="KNZ81_RS29870"
                     /old_locus_tag="KNZ81_29575"
     CDS             7749..9494
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894136.1"
                     /locus_tag="KNZ81_RS29870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29575"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_215222502.1"
                     /transl_table=11
                     /translation="MIPPPELRRAARPAALPLAGATALLALVGATHIGQAVLLALVLAR
                     VARGETAGLPALLAAVAAVVLARALLGRAQRLLAVRAGALVRVRLRDDLLAHLGGTGQG
                     ALAGARAGAVRATLVDGVEGVDAYVSRHLPHLIVTCALPPLLLVAVALVEPYAVAALAP
                     ALLLALAGPRLWDRLLARRGREHWDSYEALAADHLEALQGMAALRAAGAVGRTRARLER
                     RSAALHRATVAKMRVSLADTGLTDLAVQGGTVAAVLVACAAATTGGTAATGTYLLLMLA
                     SECFRPVRDLSREWHAGHLGLSAVDGIAALRHAEGGVPDEGTAAADWATPPEVRFEKVH
                     FTHPGRIRPALAGVAFTAPAGRVTALIGPSGAGKSTLLSLLLRQRDPDSGRVTVGGLDT
                     AAYRLDALRRGIAVVSQDTYLFRATVADNLRLARPAATSAQLHEAARAAGIHEELTRLP
                     DGYDTVIGERGATLSGGQRQRLALARALLADAPVLVLDEATSAVDERAEARITRELLAA
                     GRGRTCLFVAHRLEAVRHADHIVVLDHGRVDDAGTHSELLAADGLYARLVAAGRTVTPM
                     QQEAA"
     gene            9491..11275
                     /locus_tag="KNZ81_RS29875"
                     /old_locus_tag="KNZ81_29580"
     CDS             9491..11275
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470983.1"
                     /locus_tag="KNZ81_RS29875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_29580"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_252923040.1"
                     /transl_table=11
                     /translation="MTPPTPPEPPAGPPPHKALRSLLPVLAAHRAMTARTCAAALVDQA
                     ALVALVTLAAHTVGTAVIDGRPPSAATMALLVALVAVRALATWREMDLSHDLAYRVLAL
                     LRVRVFDGIARSAPARVAGRRSGDLASTALGDVEALEFFYAHALAQLLATGTVFTVSAA
                     LLGTREPWLLALVLPAAALLLALPVLDGRGRAARGARTRAALADLSAETVETVDGLREL
                     LAFGALNRRRARLRAYGRRLARAQRAEQSWEAGAAALRDLLVVVAVIGVVAVAGHSAVE
                     GRLHGAWTPAAMALALGALAPVADAAASLGQAGSLRAAAARVRAAADAPAGAPAPSTPR
                     PLPEGPLGLRLRGVRFGYGGTPVLDGVDLTVRPGETVALVGASGAGKSTCAHLLARYWD
                     PQEGTVTLVPEDGRPPVALRDLGDAELRSAVAVVGQEAPLFHGTLAENLLLAAPDAPPD
                     ALDRAVRACGVDTLAAGLPDGLGTAVGERGATLSGGQRARVALARALVAAPRVLVLDET
                     TAHLDHTGDAELAAALAASAPGRATLVIAHRPATVRRADRVAVLEDGRIVEEGTWEELA
                     SAGGALTRLLSREATATA"
ORIGIN
        1 gcttcctcgc cccgcacctg gcccggcgac tgcggcccgg cgccgacgcg gcggggctgc
       61 tcgggtacgc ggccgcctgc ggtgccgtcg tcgtggtctg cgccgacctg cccgcccggc
      121 tgctgctcgc ccccgtcgag accccggtcg gcgcctggac cgccctgttc ggggtgccgg
      181 tcggcgtggc tttgctcaaa tggcgcgcgc tcgcccgcag ttcaccggcc ctcgcgcccg
      241 gcgaccgggc cgccctgcgg aaggccgagc ggtgagcgcc gcgcggaccg ccgcaccggt
      301 gctccggagg ggctggaccg gcaccggggt caaggcggcc gtcctggtgg tcctcgccct
      361 cgcggccggg gtggcggggc tcgtggccgg gcccgccgtg accacggccg acgtcgccga
      421 ggtgctcgcg ggcggcggcg atccgctcgc ccggcacatc gtgctcaacc tccgtctgcc
      481 gcgcgccctg gtcgccgtca ccgccggggc ctgcctcgcg ctggccgggc tggtcctcca
      541 gtcggccctg cgcaacccgc tggccggtcc cgaggtcacc ggtgtcaccc cgggcgcggt
      601 gctcggggcg gtcaccgcga ccggactcgg cctcgccggc tggcagtcgc ccaccgccgt
      661 ggtggtggcc gcctgcctcg ggggctgcgc cggggccggg ctgctctggc tgctcgccgg
      721 gcgagagcgg ggagaccccg aacagaccgc cgtccacggc gttctggtct ccgccgtgct
      781 gaccggcgcc accgccgtgg tgctgctgat cgcccccggc gaactcggca gcgtcgtgca
      841 gtggctggtc ggctccaccg agggacgcgt ctggcggcac tgggaactcc tgtggccgtg
      901 ggccctgtgc tggggcgccg tcgcctggtt gctggccggg ccgctgacgc tgctgcggtg
      961 cggcgacgag caggccgccg cgctgggcct cgacaccggg cgggcccgcg ccgccgccct
     1021 ggcctgtgcg gtggcgctca ccgccggggc ggtctcggcg gtgggcgcgc tcggcttcgt
     1081 ggggctgctg gtcccgcacg tcgcactcgc cgtcttcggc gccgacctgc gagccaccct
     1141 gcccggcgcc gccctgctcg gcgcggtcgt ggtgggcggc gccgacgcgg gggcccaact
     1201 gctctcccgt gccctggccc aggccctgga cgcggaccgg ctcaccgtcc cggtgggcgc
     1261 cctgaccacc tgcgcgggcg ccgctctgct gctgatcgtg gcccgccgcc gcgccgacct
     1321 gcgatgagcg ggcggcaccg cacgcccccg aggcgtaccg aagcacggcc gtgcgggcga
     1381 ccgcgccgcc ggcaccgacg agtcacggcc ccgtccggcg agcgcgggcg gggccggaag
     1441 gaggagtgat ggaccatcgg gaacccggtg ccgtggtcgc ggaagggctg cggttcggct
     1501 atccgggacg cgaggtgctg cgcggggtcg acctgcggat cggcgcgggc gaactggtcg
     1561 ccctggtcgg cctcaacggc tgcggcaaga gcaccttcct gcggctcgcc gccgggctgc
     1621 tgcgcccgga cggcgggcgg gtcctgctgg acggggagga ggtggcacgg ctctcccgcc
     1681 ggggcgccgc ccgccgcgtc gccctcctcc accagtcggc gccgcccgta ccggggctga
     1741 ccgtccgcca gctggtccgg caggggcggt acgccgcccg ggggccgctc gggatgctcc
     1801 gtgacgggga cgacgcggtg agcgcgcggg cgctggccga cgccggggtc gccgactggg
     1861 ccgggcggcc ggtcgacgcg ctctccggcg gtgagcggca gcgcgtacgg ctggccatgg
     1921 cgctggccca ggacacccgg accctcctcc tcgacgaacc gaccacgtac ctggacctca
     1981 ggcatcagct ggaagtgctc cagaccgtgg tccggctgcg cgcggaacgg gatctgacgg
     2041 tggtgatggt ggtgcacgac ctcaaccacg ccgcccggtt cgccgaccgg atcgtcgccc
     2101 tccgggacgg ccgggtggcc gccgacggca agcccgccga catcgtcacc cccgccctcc
     2161 tcgccgaggt gctgggtgtc gaggggcggg tggcgccgga cgagcggggc ggctggccgg
     2221 tctgttaccc agatcaccct ctggaggccg cacgccactt gcgcaatgaa aatcatattc
     2281 attaaggtcc gtggtgcggc aggcgccacg ccgttcacgt ccaccacgca tcgaaccgaa
     2341 tggagctcaa ctcatggagc atgacaaggt gttcgccccg atcgccgacc cgggccagct
     2401 ggcccacctc tccgccaccc actccaacgc cctcgtcgag aaccccttcg acgacgccga
     2461 cgagaccggt gccgcggacg acaagtagtc agccccggcc gccggtgacg gcggccggct
     2521 gacacccgtg acgggtccgc ccggcagaaa cccccgggcg ggcccgttgc gttcggcgcc
     2581 ccacggcacc ggcgccgccc atccccccgt actccatccg acggaggtct ccgtgaccag
     2641 cagccgactc gccccgggcg ccgggatcgt caccgtcccc ggcggccggc ccgccgtacg
     2701 caccgccgag ggcgagttcc tgcacctcga caccggcgcc gccgacctcg ccgcgctcac
     2761 ccgccgcctg gtgagcggcg aagccgcctc cgacgccgaa gtggcgcgcg tcgcagcggc
     2821 gttcgagcgc gagggtcacg cggtccggcc cgcccctgaa gagggcggcc ggctcaccgg
     2881 ccgtaccgtc ctgctgctcg gcgacgcgcg gctcaccggc ccgctcgccc ggtacgcgac
     2941 cgctgaaggc gccctggccc ggcacgccac ccccgagcac gtcgcccggc tcgccgacgg
     3001 tgaaggggcg gacgcgtcga ccgccgtcgt ctggtgcctc gacgagccgg tgccgcccgg
     3061 gctctgggac gtcgccgacc ggctccccgc acacggcacg gcctggctgc gctgccaccg
     3121 cgagggcgcc cacctgtgga ccgaaccgct cgccgccgca cccggcgacg tcacctccgc
     3181 ccacgtccgc ctccgccgcc tcgccgccac ctccgcccac cgccagctcg ccgcctactg
     3241 ggccggacac cgcacccccg acaacggccc gcaccccggc gaggccgccg ccgccctggt
     3301 cgccgccctc ctcaccgccg acctcctcgc ctgggccgtg ccgggcccga actccgggct
     3361 ccccgcgcga cgcaggctcc gccgcgtcga cctgcgcgac ctcaccgtca ccgaacaccc
     3421 cgtgctgccc gtaccgccgg tggccccgct gcccggccgg gggagcggcc cggcatgacg
     3481 cccgcgacca cccgcctcac cacccccgac ggcaccaccc tcgccaccga cctccacctc
     3541 cccgccaccc cgggctccca ccccgccgtg ctgatccgca ccccgtacga ccgccgtgcc
     3601 caccgggccg aactgcgcgg ctgggcggag cgcgggttcg ccgccgtcgc ccaggacgtg
     3661 cgcggccggc acggctcggc gggggagtgg cacccgtacc gcgaccacga ggcggaggac
     3721 ggcgtggcca cgctggactg gatacgcgcc cagccgtgga gcgacggccg cgtggtcgcc
     3781 gccggggcct cgtacgccgc gtactgcgcc ctcgccgctg ccctctgccc cggcgccccc
     3841 ggcccggacg cggtgatcgc cgccgtcccc gccctcggcc tgaccgagac ggcccgcgaa
     3901 cccaccggac ccgaacgcct gtgggcgcgc ctcggctggt gggcggccca cggcgaccgg
     3961 cccgactccg cacccgacgc cctcgcgcgc accctcgccc gcgacccgcg cctgcccgag
     4021 cacctgccgc tgacccggat cgcggaccgg ctcgaccgcc cgctcccctc ctggcccggg
     4081 ctgtgggagg actgccggcg cggccgcctg gtcgcccacg gctccgccgc ccggctcccg
     4141 ctgctcgccg tcggcggcac ccgcgacccc ttcgccgagg acaccgtcgc cctctggcgc
     4201 ggctggggcg gccccgcccg gctgctgctc ggcccctggg gccacacgct cacggcgggg
     4261 acccgccccg gcaccccggg ccgcctcgac ctcggcgccc tctacgcccg ctgggccagg
     4321 gccgcgctcg acggggagat cggccccggg cggcgcggcg tcatcggcct cgcgcagagc
     4381 ggacgctggc accacctcac ggactccgtg acccggccag aagggcatga agtggccggc
     4441 gccgtgtggc ggttcggtgc cgccgacggc ctgcgcctcc tcgccggagc cgagttcacc
     4501 gccgacccgg accgtcccgt acgctccgac gacctcaccg tcccgcgtgg gcgcaccccc
     4561 gccgaccgct gcctgctcgc caccccgccg ctgccccgcc ccctcgacct ggcgggctcc
     4621 gccgaggccc ggctcaccgt cgtcgcggac acgccccgcg ccgactgggc cgtacgtgtc
     4681 gtcgccctcg acccggccgg acgcgccgac cccctcgcct tcggcatcgt ccggcgcgat
     4741 gccccgcccg gcaccccgca tcccgtcacc gtgccactcg ggaccctggg gcggaccctg
     4801 gccgccggga ccaccctgcg cgtcgagatc gccggccacc atttccccgc gcacgcccgc
     4861 aacccgcaca ccggcgagga ccccgtcacc gccacccgcc tggccgcctc ccgccgcacc
     4921 gtccgcaccg agggcagcgc cctccacctg cccgtggccg gccgcccccg ccccgtcgac
     4981 cccgtaccgg agacctgccg atgaccgccg ccctgcctct cgacgccctc gtcgaccctc
     5041 actgcggact cgtccgcgac gtcgcccccg tcccgcaccc cgagggcgcg ccgccgcgct
     5101 acaccgccat gaccgcgcac gtcgccgacg cccgccggtt cggggcctgg cccgccgacc
     5161 gggtctcgct cggcaccacc ttcggcgacc cggccggcgc ctggaccgcc gccgtcgccg
     5221 aagccgtcga acggtactgc ggcaaccggc tcccgccacc cggccacccc gacgcacccc
     5281 gccgcgccac cgccgcccag ctcaccgccg agggacacca ggtgtacggc ccggacgacg
     5341 tgcccgccta cgcgccctgg cagtaccgcc gccccgcctt cccctacgcc ccgctcacgc
     5401 ccgacacccc cgcgctttgg gcgcgcggca cggagaacgg ccgcgactgc tgggcgccgg
     5461 tcgccctcac ccacctcaac tggcgccagg gagagctgcg ttcactgccg cgcacccacc
     5521 acctgaacta cgccggcatc gccaccggac agggactcgc ggacgccgcc gaacgcgccc
     5581 tcctcgaagt ggtcgagcgt gacgccctcg aactgtggtg gcacctggac gggcccaccc
     5641 ggggcatcga ccccggcagc gtccccgggc tcgacgccga cctcgccgga tgcggcctgg
     5701 aggtgagcat cgtcgagatg ccctcggagt tcgcgccctg cgtggccgcc ctggtccacg
     5761 acgcccggcg gggtgtccac gcggccgggt tcgcctgccg cttcgacccg gccgaagccg
     5821 cccgcaaggc cgtcctggag gccgtgcaca cctgggtctt caccctgggc gccgaagccg
     5881 ccgacggctg ggtgcaccag gccgtcgagg ccggtgtcct ggcccgcggg ctctatctgg
     5941 accaccgggc cgaccgccgc tacctcgacg actgcggcga ggagttcgcc gccgtacggg
     6001 acctcggcgc ccacgtccag gcatggctcg acccgcgcct cgcgcccctc gcccgccgct
     6061 tcaccgcacc cgccctcggc accgtccccg tcgccgatct cgcgcacggc agccgggacc
     6121 ggctcgacac cgccctcgcc aagggcggcc accgcgttct caccttcgac ctgaccaccg
     6181 aggacgtcgc cgagaccgcc ctgcgcgtcg cccgcgtcct ggtcggcgga ctcgtcccca
     6241 acgcccccgc cgccttcggc tactacggct gcccccgctt cgccaccgcc gctcccgccc
     6301 ggggctggcg ctcccaaccc ccgcgcgagc cgggcgactt cactctcgcc cccgccccgc
     6361 acatgtgagc cccggccctc ccatgaccac cgacgccacc ctcggccacg ccctggccct
     6421 cgccagatca ccccgcaccc cggcccgcgc caccccaccc ccgcgccgcc cctacccctg
     6481 gaccggcacc ccgctcgccc tccccaccac cgcccccgac cccgacggcc ccgtcgacct
     6541 cgaccatctg ctccggcatg cgctgcgcgc ccgccccggt accggtggcc ggctgcgccc
     6601 cgccgcctcc gccggagcgc tccaccccgt ccgcgcccac ctcctgatcg gccccggctg
     6661 caccttgccc ccgggacggt acgcctacga tcccgaggtc caccgggtgt tccggcgcgg
     6721 cccggcaccc cacggagcgg cccccggcgt gatcgccgtt ctcaccgcca ccgccgaacg
     6781 caccgccgcc cactacggcc accgcgcctg gcccctgctg ctcctcgaca ccggccacgc
     6841 ggccgccgcc ctcgcactcg ccccgcaggg acccggcgtc cgcgtcagcc tcgacgccga
     6901 cgccgccacg ctcgcggccg ccgccgggct gcccccggcc gaccgctggc agcggatacg
     6961 gcccggcacc gagaccgaac accccctcgc cgccgtccag ctgacgcccc gccgtaccca
     7021 gtgcaccact cccgccctcg accgctggtc ggccctgccg ctcccggacc gcacccgcac
     7081 ccccacccgg cccccggccc ggccctgcgg caccggccgc ctgctggaac tgctgggcgc
     7141 cgccaccggg accgaaccga cctggcacct cgtccgccgc cccgacgccg tcaccggacg
     7201 cgccctgctg gatcgccgca gcgccgaccc ggccgccctc ggccacccgc cggacggcgg
     7261 gacggtggcc cgcatcctgc acaccgccgc caccgcctgg cccggcggcc ccgcctggtg
     7321 cgccgccgtc gccgccccca cccccgccct gttcgccccc ggccaccgca ccgccgcccc
     7381 gcaccgcctc gcccggggcg acgcccgccc cagcctcgcc cactgggccg caggccagct
     7441 ctggctcgcc gacaccggag cggtactcct cgcccacggc tgtccctcgg acgcccccgc
     7501 gcaccaggtc cgccacgacc acctcgccgc cggcttcgcc gcgggcaccg cccacgccca
     7561 cgccgccgcc gagggaatcg ccgcccgccc cgtcggctcc tggcaacagg cggatctggg
     7621 cgcggccctg ggggagaccc cgggactcga ctgggtcctg cacggcctgg cgctgggagc
     7681 cgcccgatga gccgccgccc acggcccgac cctgaccacc ccaccccgcc cggagagacg
     7741 tacccgcgat gatcccgccc cccgaactgc ggcgcgccgc ccggcccgcc gccctgccac
     7801 tggccggcgc caccgccctg ctcgccctgg tcggcgccac ccacatcggg caggcggtgc
     7861 tgctcgccct cgtcctcgcc cgggtcgccc ggggcgagac ggccgggctg cccgcgctgc
     7921 tcgccgccgt ggccgccgtc gtgctggccc gcgcgctgct cggccgcgcc cagcggctgc
     7981 tggccgtccg cgccggagcc ctggtccgcg tccgcctccg cgacgacctc ctcgcccacc
     8041 tcggtggaac cggccagggc gcgctcgccg gagcccgggc gggagcggtg cgggccaccc
     8101 tcgtcgacgg agtcgagggc gtggacgcgt acgtctcccg ccatctgccc cacctgatcg
     8161 tcacctgcgc cctcccgccc ctgctgctgg tcgccgtcgc cctcgtcgag ccgtacgccg
     8221 tggccgcgct cgcccccgcc ctcctgctgg cgctcgccgg gccccgcctc tgggaccggc
     8281 tcctcgcccg ccggggccgc gagcactggg actcctacga ggccctagcc gccgatcacc
     8341 tggaggccct ccaggggatg gcggccctgc gcgccgccgg cgccgtcggc cgcacccggg
     8401 cccggctgga gcggcgttcg gccgcgctgc accgggccac cgtggccaag atgcgggtct
     8461 ccctcgccga cacgggcctg accgacctcg ccgtgcaggg cggcaccgtc gccgccgtcc
     8521 tcgtcgcctg cgccgcagcc actaccgggg gcaccgccgc gaccggcacc tatctgctgc
     8581 tgatgctggc ctccgagtgc ttccgcccgg tccgcgacct ctcccgcgag tggcacgccg
     8641 ggcacctggg gctgtcggcc gtcgacggca tcgccgcgct gcgccacgcc gagggcggcg
     8701 tccccgacga gggcaccgcc gccgccgact gggccacgcc ccccgaagta cgtttcgaga
     8761 aggtccactt cacccacccg ggacggatcc gacccgccct cgcaggcgtc gccttcaccg
     8821 ccccggccgg acgcgtcacc gccctgatcg gcccctccgg cgccggaaag tccaccctgc
     8881 tgagcctcct gctccgccag cgcgaccccg actccggccg ggtcaccgtc ggcggcctgg
     8941 acaccgccgc gtaccggctc gacgcgctcc gccggggcat cgccgtggtc tcccaggaca
     9001 cctacctctt ccgcgccacc gtcgccgaca acctccgcct cgcccgcccc gcagccacct
     9061 cggcccagct ccacgaggcc gcccgcgccg ccggcatcca cgaggagctg acccggctcc
     9121 ccgacgggta cgacacggtg atcggcgaac gcggcgccac cctctccggc ggccagcgcc
     9181 agcgcctcgc cctggcccgc gccctgctcg cagacgcccc ggtcctcgtc ctcgacgagg
     9241 ccaccagcgc cgtggacgaa cgcgccgagg cccgcatcac ccgggaactc ctggcagccg
     9301 gacggggccg cacctgcctg ttcgtcgccc accgcctcga agccgtccgc cacgcagacc
     9361 acatcgtcgt cctcgaccac ggccgcgtcg acgacgccgg tacccactcc gaactcctcg
     9421 ccgccgacgg cctgtacgcc cgcctggtgg ccgcaggccg gaccgtcacc ccgatgcagc
     9481 aggaggccgc atgaccccgc cgaccccgcc ggagccaccg gccggcccgc ccccgcacaa
     9541 ggccctgcgc tcgctgctgc ccgtgctcgc cgcccaccgc gccatgaccg cccgtacctg
     9601 tgcggccgcc ctcgtcgacc aggcggccct cgtcgccctg gtcaccctcg ccgcccacac
     9661 cgtcgggacc gccgtgatcg acgggcggcc cccctcggcg gccaccatgg cgctgctcgt
     9721 cgctctggtc gccgtgcggg cgctggccac ctggcgcgag atggacctct cccacgacct
     9781 cgcctaccgg gtcctggccc tcctgcgcgt ccgcgtcttc gacgggatcg cccgcagcgc
     9841 ccccgcccgt gtcgccggcc gccgcagtgg cgacctcgcc tccaccgcgc tgggtgacgt
     9901 cgaggcgttg gagttcttct acgcccatgc tctcgctcaa ctcctcgcca cgggaacggt
     9961 gttcaccgtc tcggccgccc tgctgggcac ccgcgaaccc tggctgctgg ccctcgtcct
    10021 gcccgccgcc gcgctcctgc tcgccctgcc cgttctcgac ggacgtggcc gcgccgcacg
    10081 aggagcccgc acccgcgcgg ccctcgccga cctctccgcg gagaccgtgg agaccgtcga
    10141 cgggctgcgc gaactcctcg ccttcggcgc gctgaaccgc cggcgcgccc ggttgcgcgc
    10201 gtacgggcgg cggctggccc gcgcgcaacg ggccgagcag tcctgggagg ccggtgccgc
    10261 cgccctgcgc gacctgctgg tggtggtcgc cgtgatcggc gtcgtcgccg tcgccggcca
    10321 cagcgccgtc gagggccgcc tgcacggcgc ctggaccccg gccgccatgg cgctggcgct
    10381 cggcgccctc gcccccgtcg ccgacgcagc cgcctcgctc gggcaggccg gcagcctgcg
    10441 ggccgccgcc gcccgggtcc gggccgccgc cgacgccccc gccggagccc ccgcgccgag
    10501 cacgccgcgc ccgctgcccg agggccccct cggcctccgg ctgcgcggcg tgcggttcgg
    10561 gtacggcggc acgcccgtgc tcgacggggt ggacctcacc gtccgcccgg gcgagaccgt
    10621 cgccctggtc ggcgcctccg gcgcgggcaa gtccacctgc gcgcacctgc tggcccgcta
    10681 ctgggacccc caggagggca ccgtcaccct cgtccccgag gacggacgac cgccggtcgc
    10741 cctgcgagac ctgggcgacg ccgagctgcg gagcgccgtc gccgtcgtcg gccaggaagc
    10801 ccccctcttc cacggcaccc tcgccgagaa cctgctgctg gccgcccccg acgccccgcc
    10861 ggacgcgctg gaccgcgcgg tacgggcctg cggcgtcgac accctcgccg ccggactccc
    10921 cgacgggctg ggtacggccg tgggggagcg gggtgccacc ctctccggtg ggcagcgggc
    10981 ccgggtcgcc ctggcgcggg cgctggtcgc cgctccccgc gtactggtcc tggacgagac
    11041 cacggcccac ctggaccaca cgggggacgc ggaactcgcc gccgccctcg ccgcctcggc
    11101 ccccgggcgc gccacgctgg tcatcgccca ccggcccgcc accgtgcgcc gggccgaccg
    11161 cgtcgccgtc ctggaggacg gccggatcgt ggaggagggc acctgggagg agctggcgtc
    11221 cgccggcggc gcgctgacac gcctgctctc ccgggaggcg acggcaaccg cctgacctgt
    11281 gccgacgcgc acgcccgcgt gcacgtggaa gggccggggt ccctcgcggg gaccccggcc
    11341 ctgtcgtccg ggggaggaat gctgcggc
//
