LOCUS       NZ_CP076385            10216 bp    DNA     linear   CON 27-AUG-2024
DEFINITION  Streptomyces sp. G11C(2021) chromosome.
ACCESSION   NZ_CP076385
VERSION     NZ_CP076385.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. G11C(2021)
  ORGANISM  Streptomyces sp. G11C(2021)
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137224)
  AUTHORS   Undabarrena,A., Serna,N., Zamora-Leiva,L., Cumsille,A., Gonzalez,V.,
            Valencia,R., Ugalde,J., Reyes,F., Olano,C., Salas,J.A. and Camara,B.
  TITLE     Towards deciphering Streptomyces albidoflavus metabologenomics:
            insights into a new member of the tetrahydroisoquinoline family
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7137224)
  AUTHORS   Undabarrena,A., Serna,N., Zamora-Leiva,L., Cumsille,A., Gonzalez,V.,
            Valencia,R., Ugalde,J., Reyes,F., Olano,C., Salas,J.A. and Camara,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2021) Laboratorio de Microbiologia Molecular y
            Biotecnologia Ambiental, Universidad Tecnica Federico Santa Maria,
            Av. Espana 1680, Valparaiso 2340000, Chile
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024499195.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 07:37:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,192
            CDSs (total)                      :: 6,097
            Genes (coding)                    :: 5,931
            CDSs (with protein)               :: 5,931
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 166
            CDSs (without protein)            :: 166
            Pseudo Genes (ambiguous residues) :: 0 of 166
            Pseudo Genes (frameshifted)       :: 66 of 166
            Pseudo Genes (incomplete)         :: 127 of 166
            Pseudo Genes (internal stop)      :: 16 of 166
            Pseudo Genes (multiple problems)  :: 38 of 166
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:57:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 777514
            Orig. end                         :: 787730
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP076385.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    486..501
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     misc_feature    1798..1812
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     gene            complement(3223..3627)
                     /locus_tag="KNZ81_RS03010"
                     /old_locus_tag="KNZ81_03045"
     CDS             complement(3223..3627)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010636353.1"
                     /locus_tag="KNZ81_RS03010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_03045"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_230535157.1"
                     /transl_table=11
                     /translation="MAYLVELPVSGAGGAEGGDEGAASAPADATGIVRIEIDEVADGLV
                     QVARPGQVVARATRPLKEMLAGIRPVAENFVEGFRDMALRPDEIVVEFGLSVSAEADVV
                     ISKSSGQANFQVTLTWSTPPSGEPAADAAG"
     gene            3821..4285
                     /locus_tag="KNZ81_RS03015"
                     /old_locus_tag="KNZ81_03050"
     CDS             3821..4285
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640757.1"
                     /locus_tag="KNZ81_RS03015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_03050"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_215220499.1"
                     /transl_table=11
                     /translation="MRIRAVHPGELTTLQDIERAAGVWFREIGMAEIADDEPPPVEELA
                     RYVRAGLARVADDETGRPVAYLIADRVDGNLHVEQVTVHPDSARRGVGRALLDHTAGRA
                     RDEGAAALTLTTFTEVPWNAPYYERCGFRVLAERELTPGLREIRRAEATH"
     misc_feature    complement(4515..4532)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.07"
                     /tool="antismash"
     misc_feature    4951..4971
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.98"
                     /tool="antismash"
     gene            5001..5216
                     /locus_tag="KNZ81_RS03020"
                     /old_locus_tag="KNZ81_03055"
     CDS             5001..5216
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="KNZ81_RS03020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_03055"
                     /product="hypothetical protein"
                     /protein_id="WP_008412458.1"
                     /sec_met_domain="strepbact (E-value: 4.3e-37, bitscore:
                     125.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYTPQVETAEIADSELDNISGGLVNGLVGSVTSSLDSVAPVSDT
                     LGTVTGVVEQTTGLNTAPVTGLVAGL"
     misc_feature    5015..5030
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.97"
                     /tool="antismash"
     gene            5414..6220
                     /locus_tag="KNZ81_RS03025"
                     /old_locus_tag="KNZ81_03060"
     CDS             5414..6220
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640761.1"
                     /locus_tag="KNZ81_RS03025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_03060"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_215220498.1"
                     /transl_table=11
                     /translation="MRFRQQALTKLQSPEQLDLPVRFARPQGLLVLAVTLVVMAAGGVW
                     AVTGSVDTTLTAPGVLTHAQGSYVVQSTVSGQVTAVRTAEGRRVARGTPLLTVRTTRGD
                     VTIRALAAGRVTALAAATGAVVTTGTDLAAVERQKNPDDPLLAVLYAPADSGASLRPGA
                     KADLTVQSVPAQSYGVLRGTVKSVGRTARTRQQISADLGSAQLGEEFSRNGPPIAVEVR
                     LHPAKSTRSGYTWSTSDGPPHPLTTLTLVDGAVHLDEQRPADWLLP"
     gene            6217..8514
                     /locus_tag="KNZ81_RS03030"
                     /old_locus_tag="KNZ81_03065"
     CDS             6217..8514
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640763.1"
                     /locus_tag="KNZ81_RS03030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KNZ81_03065"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_215220497.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.2e-36, bitscore:
                     121.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPADAPAAGTGSTAPPTPGGRRGRRAAPSSGRRRAAPPRRTPR
                     RRPVRTPTVLQMEAVECGAACLAMVLAHHGRHVPLEELRIACGVSRDGSRASNVLKAAR
                     SYGLTAKGMQMEPAALREVQAPAVLFWEFNHYVVHEGFLRRPGRRGAVRLNDPDKGRRV
                     VSAEEFDASFTGVALVLEPGPSFRKGGRKPGLLGALPARLRGTGATLLTALLASLLLVV
                     VGAALPALSRTYIDLFLIGERTSVLGPLFVAMGALVALTASLTALQQANLLRGRIISST
                     LSSARFLRHLLRLPVTFFAQRSPADLVQRLQSNDTVAETLARDLAAAAVDGVVVVLYAL
                     LLWTYDPQLTLVGVGIALLNIVAMRVVIQLRATRTQKLRADNARLTTTAYTGLQLIETM
                     KATGGEDGFFRRWAGQHATTLEEQQRLGVPTAVLSVVAPALATFNSALILWIGGLRAVE
                     GHLSVGLLVAFQALMVRFTAPLTRLNGVAGRIQDFAADVTRLRDVEAFPADGLYRREGG
                     AGGEADTRRLAGRVELEGLTFGYSPLDPPLLTDFSLTVGPGRQVALVGGSGSGKSTVSR
                     LLAGLYQPWEGTIRIDGQPLTEIPRSALAASVSFVDQDVFLFEGTVRENVTLWDPSLPD
                     EAVRTALRDAGLEEVIARRTDGIHARVEQDGRNFSGGQRQRLEIARALVRRPSVLVLDE
                     VTSALDAETEQRVMAALRRRGCACVIIAHRLSTVRDSDEIVVLDGGRVVERGRHAELVA
                     RGGAYAALVEEK"
ORIGIN
        1 agtcgttcca gcccatgtgg tagagcttgc cgtgcgattc ggcgagacga ccaggggaac
       61 ggatctttgt gagggcgctc ccggtcaggg gcgctctgga gatcgcctcg cccttgtcca
      121 gatccaggac gcgcacttcg tcaccccagt ggagcgcgac gcgccggccg gtctcgtcga
      181 ccgcctccag cgtgcacatg tccgtggtgt acgcctcgtc ccgctcgcgg taggagcggc
      241 cggcctcggc gccgtcggag gtccggtagc ggcggatgac ggactgcccg tcctcctcgc
      301 ggcagacgac ggcggtgctg cggtcaccgg agaggtagat ctcctgcgcc ccggagagga
      361 gaggcgtggc actgccggtg gccgggtcga cggaggccag gacccgagtg cccgcgctcc
      421 cgtaggacgc cgccaggagc gtccgcccgt ccggggcgaa cgcgagcggg cctgtcagat
      481 ccgggggcac gggggcgtca ccggtgcgtg cgtcgctctc caggttccac cgcaccagcc
      541 ggtccccgac gacagaggcg aggctgcgcc cgtccgccga catcgcggga agcacgtcag
      601 ggtccagacg cacaccgggc tcgccgccca gtcgccgcct cggcccgagc aggcccgggg
      661 catcggtgtc cacgtcgatc cagaccgcct tgccgtccac ctggacatag gcgacgcgct
      721 tcccgtcctc ggccaccacg ccgtgcatca cctgcccggt cgagggcacc tgcgcgctgc
      781 gcacccgtcc ggaggcgacg ccggtgaaca gggtggcccg gccgagctgt gagacggcga
      841 ggaccacgtc gccgtccgcg ctggtcccga actccctgac ggtgcccagg acgccggaga
      901 gcacccggtc gtagccctgg taccgcaagt actgcctcag gagttcgtcg cgcgcctcct
      961 gggtcggagc ggtcctgtgg gcggccaggg ctttcagcac gccgagggcg ggttcggtgc
     1021 gcgtgtcgtc cgccgcggcc aaagccagcg cgcgggacgc ggcctccgcg gcacgttccc
     1081 ggctctcctc gcgcgtggcg tggaacgccg ccagggccac gatgaccagc agcacgacga
     1141 agctgatcgc cgagagcgtc acccgtcgcc ggcggaccct cgcccggcgt cgggtgtgcg
     1201 cggcctccag atagcgccgt tcggcgtcgg tgagttcgtc gccgcgtgcg tccagccact
     1261 cttcggaccg ggcgagttgc agaggcgtcg gcagcagctc cggagggcgt tcggcctgtt
     1321 cccagcggtc catgtccctt cgcagtccgg cgcgccactc caggaaggcg cggtcaccgg
     1381 tggcccagcc ggagagcttc tcccacccgg tgatcagggc ctcgtgggcg agttccacgg
     1441 tctcgatgcc ctcggtgttc cggccggtca ccaacagccg tgtgctcgcc aggcgttgcg
     1501 cgacacgcca ctccccggct cccagttcgg tgcgcagtgc cgtccgtcgg gcgggcgcgg
     1561 gcagatcggc ggtgacctgg acgagccggg tgaacagccg tctggcgacc tcctcgtcct
     1621 ccgggaacac gcaggcactc cactcatcgt cggcgtgccg gcccagggca ccgctgacgc
     1681 cgccgagtcg ctcgtaggcg cggtgggtca gcaggccgcg ctcctgtcgc tgccacaaca
     1741 ggtcgagggt gaggccgagg agcggcagct cgcccggtcc cgcgccggtg tcggcgagga
     1801 tgcgctcggc gagctgaggc tcgtaggaca ccccgggtac ggcgtcgacg ggtgcggtca
     1861 cgatctcgcg caggcgcccg gggtccggcg gggcgagcgc gtacaggtgc tcgccggcca
     1921 ccgggcccag gcgcggatcg gccagcaccg gctccaggaa gtcggcgcgc agcgtcatca
     1981 gcacgcggac ggtctccggc agggtgccgc ccgcgagcag gtcggcgaat tcgtcggctt
     2041 cgggcgggtc gaggccgagg acctcctcga actggtcgac caccagcagc agtcggctgc
     2101 cgtgccgcag ctggagcagc cgtgtcaccg tgtccgccgg gccgtggcgg cgcagcacag
     2161 cggcgagttc ggccgtccgc tcctggcgct cggtctcggc caggccgggt tccagcaacg
     2221 gcagcagtcc tgccgcgagg gaagcgaacg gggcactgcc gcgcgtcggc cgcaccacca
     2281 ccgcctgggc gccctgcgcg cgcaggaggg gcacgactcc ggccagggcc agcgacgact
     2341 tgcccgagcc cgacggtccc acgacggtga cacggcgctc ggtggacagc gcccgcgcca
     2401 cctcctcgct ctccgcccgc cggccgtgga agagcgcggc gtcggcctcc ccgaacgccg
     2461 acagaccccg gaacggcgac gggggcagcg cgaccgcacg caactcgggc cggaccgcca
     2521 gcaagccgct cgtgggcacc aggtagctga cgggcggctc ccccgactcg gcgaccgtca
     2581 ccatgccgac cacaccggag agctggtcgt cccacaccgg ggcgccgctg aaaccccgcg
     2641 acaccggata gccgtcaccg gcgagatcgg cctgcaccca gccgtccgcc tgccgcccgc
     2701 gcagcacgcc cgcgtgccag accccacccg ggcgcccggc gggcagcccg tacgcccgca
     2761 acgggtgccc ccacaactcg tccgcctcga ccagccgcac cggccccgcc cccggaagcg
     2821 gcgcctccag ccgtagtacg gcgacatcgg cgggcaggac gggaccggtt cggccgggcg
     2881 accactccgt acgggcggcg ggcaccgggg gtacctcggt gggcgccggc ggcggcaccc
     2941 agtgctcgac acgggccgtg gtcaccggcg cgccgccgtc gcgccgcggg gcgggcacca
     3001 ggggaaggtc gacctggatc cgggcagcgg cgtcgggtgc ctcgtcccct gtcgtcccca
     3061 gggccgcctg gacgacgtgc gcgcaggtca gggcgagggt gtcggagacc aggaaggcca
     3121 caccgacccc ttgcccgcgg ccgtcgcgga cccgtagtac ggccgcgtcc agggaccggg
     3181 ggcccggcac caccggacgc tcgggcggtg acccgggcac cctcaccccg ccgcgtcggc
     3241 cgccggttcg cccgacggcg gggtggacca ggtcagggtg acctggaagt tggcctgacc
     3301 gctcgacttg gagatgacca cgtccgcctc ggccgacacg gagagaccga actcgacaac
     3361 gatctcgtcg ggtcgcagcg ccatgtcgcg gaacccctcc acgaagttct ccgcgaccgg
     3421 ccggatcccg gcgagcatct ccttcagcgg ccgggtcgcc cgcgccacca cctgcccggg
     3481 gcgcgcgacc tgcaccagcc cgtccgcaac ctcgtcgatc tcgatcctga cgatgccggt
     3541 cgcgtccgcc ggagcggacg cggccccctc gtcgccccct tcggcaccgc ccgccccgga
     3601 caccggcaac tcgaccagat acgccatgtt tcccccttca cgacacctgc gacgctggcc
     3661 cagcacccta ccgacggtgt cggcaccgcg aggctcgaac gtcgcgaaac acccctgtgc
     3721 caccacgatc tggccgaacg tcgacgaagg cacgcaacgc cgcccccgcc cgcccccttt
     3781 tcccgttgct tcccgccccc gcgcaccgga ccatgccccc atgcgtatcc gagccgtgca
     3841 ccccggcgaa ctgacgaccc tccaggacat cgagcgggcc gccggcgtct ggttccggga
     3901 gatcggcatg gcggagatcg ccgacgacga accgccgccg gtggaggaac tggcccggta
     3961 cgtacgggcg gggctcgccc gggtggcgga cgacgagacc ggccggcccg tggcgtacct
     4021 gatcgcggac cgggtcgacg ggaacctcca cgtcgagcag gtgacggtcc atccggacag
     4081 cgcgcgccgg ggtgtcggcc gggccctgct ggatcatacg gccgggcggg cccgggacga
     4141 gggggctgcg gcgctgacgc tcaccacctt caccgaggtg ccgtggaacg cgccgtacta
     4201 cgagcggtgc ggcttccgcg ttctggcgga gcgtgagctg acgccggggc tgcgggagat
     4261 ccggcgggcc gaggcgacgc actgactgga ccggtggcct cgctgctgca tgcgccggga
     4321 ggtgtgagca gagccgtcca gggagacagc tggtccgccg ccggggaatg cccgccgccg
     4381 accgcccttt cgcggccttg ccggtaattc cgctcccgcc tcgccgtccg cttttcgcgg
     4441 tgcgcaagaa ttcgccgccc gacggcagtt cccccgcttc cgctccttct tcccctcgct
     4501 gcggactctg ttcctccaca tgttgggaac atggccttct cagatccgtc cgcacacgaa
     4561 tccgccgcac cccggaacgg gttctcctgc ggtgaatctg cacagccgtg ccgcagctcc
     4621 gtcaccgcca cccatacctt caccgtgtgt ggacggccga ggtcggcggc ccgcaccagg
     4681 gcttcacagc aaggggtgtg gtgtacaccc gagcgtgacc ccaccccgta cggcggcggg
     4741 aaggtgtgaa ggtgatgccg ttctcctgtg cccgattccg cacacggtgg tgaggagaac
     4801 ggcaccgccc gccgtattcc gctctcgtcg attggccgcc ccgcgcaccg tcgtgctttg
     4861 atccatcgca ctgcggcgcc gcccccggaa ctgaaaggtc atcacctttc gccccggggg
     4921 ccgccagaag atttcccctt cttctgcacg agtgcgtcgc ggtggctatt tccgtcagtg
     4981 atgcgaaggg aactcccccc atgagctaca ccccccaggt cgagaccgca gagatcgccg
     5041 acagcgagct ggacaacatc tccggcggcc tcgtgaacgg cctcgtcggc tcggtcacct
     5101 ccagcctcga ctccgtcgcc ccggtctccg acaccctcgg caccgtcacc ggcgtcgtgg
     5161 agcagaccac cggtctgaac accgccccgg tcaccggcct cgtcgccggt ctctgagacc
     5221 ccacgcgtcg cctgacgacg cgtgcggccc gctgaggcgg accgctcggc cggtgccccg
     5281 gacccgctcg ggttccgggg caccggccgc ctccttgtcc tcccccggac gcccgcgcgg
     5341 cgtccccagc accacggcga cacccggccg cacggccgaa gaggccggtg cccggcagcc
     5401 gaggaagtct tccgtgcgct ttcgccaaca ggccctgacc aagctccagt cgcccgaaca
     5461 gctggacctg ccggtgcggt tcgcccgccc gcagggactc ctggtcctcg ccgtcaccct
     5521 cgtcgtgatg gcggccggcg gcgtgtgggc cgtcaccggt tcggtcgaca ccaccctcac
     5581 cgcgccgggc gtcctcaccc acgcccaggg cagctacgtc gtccagtcca ccgtctccgg
     5641 ccaggtcacc gccgtccgca ccgccgaggg ccgccgcgtc gcccgcggca ccccgctgct
     5701 gaccgtccgc accacgcggg gcgacgtgac catccgcgcc ctggccgccg ggcgggtcac
     5761 cgcgctggcc gccgccaccg gcgccgtcgt caccaccggc accgacctgg ctgccgtcga
     5821 gcgccagaag aacccggacg acccgctcct cgcggtgctc tacgcccccg ccgacagcgg
     5881 cgcgtccctg cggcccggcg ccaaggccga cctcaccgtg cagtcggtgc cggcccagag
     5941 ctacggcgtg ctgcgcggca ccgtgaagtc ggtcggccgc accgcccgga cccggcagca
     6001 gatctccgcc gacctcggct ccgcccagct cggcgaggag ttctcccgga acgggccgcc
     6061 gatcgccgtc gaggtccgcc tgcaccccgc gaagagcacc cgcagcggtt acacctggtc
     6121 gacctccgac ggcccgccgc acccgctcac caccctcacc ctcgtcgacg gcgccgtcca
     6181 cctggacgaa cagcgcccgg ccgattggct cctcccgtga ccgcacccgc cgacgccccc
     6241 gccgccggga ccggctccac cgccccgccc accccgggcg ggcgccgggg ccgccgcgcc
     6301 gccccctcct ccggccgccg ccgcgccgcg ccgccgcgcc gtacgccccg gcggcggccc
     6361 gtccgcaccc ccaccgtcct gcagatggag gcggtggagt gcggcgccgc ctgcctcgcc
     6421 atggtcctcg cccaccacgg gcggcacgtc ccgctggagg agctgcggat cgcctgcggc
     6481 gtctcccgcg acggctcgcg cgccagtaac gtcctcaaag ccgcccgcag ttacggcctg
     6541 accgccaagg gcatgcagat ggaaccggcc gccctgcgcg aggtgcaggc ccccgccgtg
     6601 ctgttctggg agttcaacca ctacgtcgtc cacgaggggt tcctgcggcg tcccgggcgg
     6661 cgcggcgcgg tccgcctcaa cgaccccgac aaggggcgcc gggtggtgag cgccgaggag
     6721 ttcgacgcct cgttcaccgg cgtcgccctg gtcctcgagc cgggcccctc gttccgcaag
     6781 ggcggccgca aacccgggct gctcggcgcg ctcccggccc ggctgcgcgg caccggcgcc
     6841 accctgctga ccgcgctcct ggccagcctg ctgctggtcg tggtgggcgc ggcgctgccc
     6901 gcgctcagcc ggacgtacat cgacctgttc ctgatcgggg agcggacctc ggtgctcggg
     6961 ccgctcttcg tggcgatggg tgcgctggtg gcgctgaccg cctcgctgac cgcgctccag
     7021 caggccaatc tgctgcgcgg gcggatcatc tcctcgacgc tgagcagcgc ccggttcctg
     7081 cgccatctgc tgcggctgcc ggtgaccttc ttcgcccagc gctcccccgc cgacctggtg
     7141 cagcggctcc agtcgaacga cacggtggcc gagaccctcg cccgcgacct ggcggccgcc
     7201 gccgtcgacg gggtggtggt ggtgctgtac gcgctgctgc tgtggacgta cgacccgcaa
     7261 ctgaccctgg tcggggtggg gatcgcgctg ctgaacatcg tggcgatgcg ggtggtgatc
     7321 cagctgcggg ccacccggac gcagaagctg cgggccgaca acgcgcggct caccaccacc
     7381 gcgtacaccg ggctccagct catcgagacg atgaaggcga ccggcggcga ggacggcttc
     7441 ttccggcggt gggcggggca gcacgcgacg acgctggagg agcagcagcg gctcggggtg
     7501 ccgacggcgg tgctgtcggt ggtggccccg gccctcgcca ccttcaacag cgcgctgatc
     7561 ctgtggatcg gcggactgcg ggcggtcgag gggcatctgt cggtcgggct gctggtggcg
     7621 ttccaggcgc tgatggtgcg gttcacggcg ccgctgaccc ggctcaacgg cgtcgccggc
     7681 cgcatccagg acttcgcggc cgacgtgacc cggctgcggg acgtcgaggc gttcccggcg
     7741 gacgggctgt accgccgcga gggcggggcg ggcggcgagg cggacacccg gcggctggcg
     7801 ggacgggtgg agctggaggg gctgaccttc ggttacagcc cgctggaccc gccgctgctg
     7861 acggatttct cgctgacggt cggtccgggg cggcaggtgg cgctggtcgg cgggtcgggc
     7921 agcggcaagt cgacggtatc ccggctgctg gcgggcctgt accagccgtg ggagggcacc
     7981 atccgcatcg acgggcagcc gctcaccgag atcccgcgct ccgcgctggc cgcctcggtc
     8041 tccttcgtcg accaggacgt cttcctcttc gagggcacgg tgcgggagaa cgtcaccctc
     8101 tgggacccct cgctgcccga cgaggcggtc cgcaccgcgc tgcgtgacgc cggactggag
     8161 gaggtgatcg cccgccgcac ggacggcatc cacgcccggg tcgagcagga cgggcggaac
     8221 ttctccggcg gccagcggca gcggctggag atcgcccggg ccttggtgcg ccgccccagc
     8281 gtgctggtgc tggacgaggt gaccagcgcc ctcgacgcgg agaccgagca gcgggtgatg
     8341 gcggcgctca ggcggcgcgg ctgcgcctgc gtgatcatcg cgcaccgcct ctccaccgtc
     8401 cgcgacagcg acgagatcgt ggtgctggac ggcggccggg tcgtggaacg cggacgccac
     8461 gccgaactgg tcgcccgggg cggggcgtac gcggccctgg tcgaggagaa gtgagatgac
     8521 gggcacccag caggcttccc accccgcccc ggcggccgac ccggtgacgg cggcgctcgg
     8581 cggactcggc gcaccggtgg cgggggccga cgggtcggcc ctgccgctcg gcgggccctc
     8641 ggcgctctgg ctggtcaccg agggcagcct cgacctcttc gcggtggcgg ccgccgagga
     8701 cggccactgg cactacctcg gccgcctgga ggccggcacg ctcctgctcg gcgccgtcga
     8761 gggcccccgc cacaccctgg tgggccgcct cacctcccac tgcgccgtac gccgcctgcc
     8821 gctgcgcgag ctgtacgcgc cgcagggcgc cgaggggtac gaggggtacc ccgggtacga
     8881 gccggtcgcc gggccgctgg agcacgcggt ggggctcggc ctcggccggg ggctcgccgt
     8941 gctgttcgcg gcaccccagg cggacgggcc cgcggcgggc tccgggcccg ccgacgagga
     9001 cgtgctgtgg gtggacgtcc cgccgggcag tgtccggcgg ggggccgagt tcgccgccga
     9061 ggcggcggcc gacctgctgg tcggcggagc gctgtggcag tccctggtgg accagcagta
     9121 ccgcctgctg accgccgtcg acggctgggt ggagcggctg gagcgggccc acgaggaccg
     9181 ggcggcggcc ggtatccggg ccggtgaggc ggtacgggag cgggccgacc aggcgctgct
     9241 cgactcgatc ggccgccgcg accgctcccc ccgggcacgc ggcgaggcgg gcgacgacgc
     9301 ggtgtacgcg gtcttccgcc aggtcgcgcg ggcgagcggc atcgcgctgc cggaggcggc
     9361 ggcgcgttcg gtcgcgggcc gcggacggct cgacccggtg gagcggatgg ccgccgccgc
     9421 ccggctgcgc acccgcccgg tgcggctggc cggcgagtgg tggcgcaccg acgccgggcc
     9481 gctggtgggg cggcgcgcca agtccggcgc gccggtggcc ctgctctggc ggcgcggccg
     9541 gtacgaggcg ctcaacccgg cgaccggcgc acgtatccgg atcggcgcca aggaggcggc
     9601 cgagttcgag gaacgcgcca cgatgctcta ccggccgctg cccgagaggc cgctgacgct
     9661 gcgccggctg atgctcttca gcctgcgcgg ctcccggggc gacctgcgca acctcgtcct
     9721 gagcggcctg gtcaccgtgg cgctgggcgc gctggtgccg gtggcgaccg ggcaggtgct
     9781 cggcgcgtac gtgccgagcg cgcagaccgg cctgatcgcg cagatgtgcg tggcggtgat
     9841 ggtggccggg gtggtctcgg cggcgttcat gctgctccag tcgctgacgc tgctgcgcct
     9901 ggaggggcgg atcgaggcgg cgttgcagcc ggccgtctgg gaccggctgc tcaggctgcc
     9961 gacggccttc ttcgcggacc gttccaccgg cgagctggcc agtgccgcga tggggatcag
    10021 cgcgatccgc cgggtgctgt cggggatcgg gccgaccgcc gtgcagtcgg tgacggtggc
    10081 cggggtcaac ctggtgctgc tgctggtgca cagcgtgccg atggcgctgg cggcgatcgg
    10141 ggtgctgctg gtggtctcgg tggtctttct gctgctgggg ctctggcagg tgaagtggca
    10201 gcggaagctg gtggag
//
