LOCUS       NZ_AP026074            23195 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 plasmid SNP1.
ACCESSION   NZ_AP026074
VERSION     NZ_AP026074.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1073703)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 731784
            Orig. end                         :: 754979
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026074.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23195
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="10"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23195
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23195
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13195](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13195)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(655..668)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.55"
                     /tool="antismash"
     misc_feature    665..675
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     CDS             complement(742..894)
                     /gene="allorf_0732526_0732678"
                     /locus_tag="allorf_0732526_0732678"
                     /protein_id="allorf_0732526_0732678"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MQVANHLTAAVGQPADRDELTALYSGGVEKQEARRSHASSCRRPH
                     LTPPP"
     CDS_motif       complement(778..894)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQVANHLTAAVGQPADRDELTALYSGGVEKQEARRSHAS"
                     /locus_tag="allorf_0732526_0732678_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(742..777)
                     /prepeptide="core"
                     /locus_tag="allorf_0732526_0732678_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.50"
                     /molecular_weight="1224.4"
                     /monoisotopic_mass="1223.7"
                     /core_sequence="SCRRPHLTPPP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQVANHLTAAVGQPADRDELTALYSGGVEKQEARRSHAS"
                     /leader_location="[777:894](-)"
                     /alternative_weights="1242.4"
     misc_feature    complement(891..900)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.12"
                     /tool="antismash"
     misc_feature    complement(966..983)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.28"
                     /tool="antismash"
     misc_feature    complement(993..1007)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.16"
                     /tool="antismash"
     misc_feature    994..1008
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.26"
                     /tool="antismash"
     gene            1054..2847
                     /locus_tag="HEK616_RS40010"
                     /old_locus_tag="HEK616_81440"
     CDS             1054..2847
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387706.1"
                     /locus_tag="HEK616_RS40010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81440"
                     /product="coagulation factor 5/8 type domain-containing
                     protein"
                     /protein_id="WP_410011391.1"
                     /transl_table=11
                     /translation="MPTPPADATAHRTSRPSRRTVLAAMAAALPAAGLPVLSSRASGTP
                     AAAALPGGGDLGPNVLVFDPATPNIQGKLDEIFKQQESAQFGTARYALLFKPGTYNGLN
                     AQLGFYTSIAGLGLSPDDTTINGDVTVDAGWFNGNATQNFWRSAENLALIPVNGTNRWA
                     VAQAAPFRRMHVKGGLNLAPDGYGWASGGYIADSRIDGTVGPYSQQQWYTRDSSVGGWH
                     NAVWNMVFSGVEGAPGQTFPDPPYTTLDTTPISREKPFLYLAGGDYRVFLPEKRVNARG
                     TTWGNGTPRGESLPLSQFYVAKPGTDAATLNAALAQGLNLLLTPGIYHVDRPIEVQRAN
                     TVVLGLGYATIVPDNGVTAMKVADVDGVRLAGFLIDAGPVNSATLLEVGPDGASADHAA
                     NPTTVQDVFVRIGGAGPGKATTSMVINSNHTIIDHTWVWRADHGDGVGWETNRADYGIR
                     VNGADVLATGLFVEHFNKYDVEWRGERGRTVFFQNEKAYDAPNQAAVQNGNTKGFAAYK
                     IADTVTTHEGWGLGSYCYYNVDPTIRQDHGFEAPHKPGVKFHDLLVVSLGGKGQYEHVI
                     NDVGAATSGTSTVPSTVVSYP"
     gene            3021..3413
                     /locus_tag="HEK616_RS40015"
                     /old_locus_tag="HEK616_81450"
     CDS             3021..3413
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS40015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_81450"
                     /product="hypothetical protein"
                     /protein_id="WP_261958160.1"
                     /transl_table=11
                     /translation="MKAFVLRKVGEVGVMDKPIPEPWEATFRVTKPGGRISNVGYHGES
                     PEPLRIPLEPFGYGMSDKQVYGGFNRGGRGWLRRIFRLMETGKVDPTPMTTHEFGFDEI
                     ERAFTMMASKEGGIIKPLIHFDSAGG"
     gene            complement(3802..4782)
                     /locus_tag="HEK616_RS40020"
                     /old_locus_tag="HEK616_81460"
     CDS             complement(3802..4782)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380457.1"
                     /locus_tag="HEK616_RS40020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81460"
                     /product="S8 family peptidase"
                     /protein_id="WP_261958161.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 8.5e-25, bitscore:
                     83.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASGGRASSGSAPVSPGTVGKSSGIAQTAASPITRHVPWNLDILD
                     QRSRPLNGNFTTTATGKGVHVYVIDTGMDVAHKEFGGRARLGADFVGPKDSGDCFSEAG
                     MGHGTFVAGIIGGTRYGVAPKAELVRVQGIQCESEGGGSPAAAEAALVKSVKWVTAHAQ
                     KPAVVNMSLNLDHRSAALESAVKKMVDAGIPTVVSAGNFHDDACKHSPAGVPGTIVVAA
                     STSNDRAWSDGGSYGSGFGRCVDLYAPGQKVTAALAGGGTTTDNDGATSWAAPHATGVI
                     ALYLSAHPHATANEVHLWLDHTATRGVVRGVRSDTPNRLLNAGGL"
     CDS             complement(4923..5075)
                     /gene="allorf_0736707_0736859"
                     /locus_tag="allorf_0736707_0736859"
                     /protein_id="allorf_0736707_0736859"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MASHRRMQRARGAALHGSGLGADRERPAGTALPPWSSCALTVYEA
                     GIWGT"
     CDS_motif       complement(5022..5075)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MASHRRMQRARGAALHGS"
                     /locus_tag="allorf_0736707_0736859_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4923..5021)
                     /prepeptide="core"
                     /locus_tag="allorf_0736707_0736859_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.00"
                     /molecular_weight="3213.6"
                     /monoisotopic_mass="3211.6"
                     /core_sequence="GLGADRERPAGTALPPWSSCALTVYEAGIWGT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MASHRRMQRARGAALHGS"
                     /leader_location="[5021:5075](-)"
                     /alternative_weights="3231.6"
                     /alternative_weights="3249.6"
                     /alternative_weights="3267.6"
                     /alternative_weights="3285.6"
     gene            5166..5945
                     /locus_tag="HEK616_RS40025"
                     /old_locus_tag="HEK616_81470"
     CDS             5166..5945
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173248.1"
                     /locus_tag="HEK616_RS40025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81470"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_261958162.1"
                     /transl_table=11
                     /translation="MDQDERLCHASSFGAAAAAYAEHRPDYAQAAVRWALAPAPGPRVL
                     DLGAGTGKLTATLVALGAEVVAVEPDPEMLAELRRSLPAVRALSGSAEAIPLPDASVDA
                     VLAGNAMHWFDMAVAGPEIARVLAPGGLLGGLWNLMDDQVEWVAGLARISGSAAIGPRD
                     TPTSWRAATADMHLPKTGVAARFGSPEQAEFPHGQRRTADSLVATLATRAGMLVMPEEE
                     REATLGRIRAFLAGRPETAGGEFTLPMLTGALRVRRL"
     CDS             complement(6206..6388)
                     /gene="allorf_0737990_0738172"
                     /locus_tag="allorf_0737990_0738172"
                     /protein_id="allorf_0737990_0738172"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSLMGTRKSEQAAETHGHTRPKVPKPDPRHRRRFRISPPRCTAVG
                     STPAYAVPRLDQGDR"
     CDS_motif       complement(6350..6388)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSLMGTRKSEQAA"
                     /locus_tag="allorf_0737990_0738172_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6206..6349)
                     /prepeptide="core"
                     /locus_tag="allorf_0737990_0738172_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="5262.9"
                     /monoisotopic_mass="5259.8"
                     /core_sequence="ETHGHTRPKVPKPDPRHRRRFRISPPRCTAVGSTPAYAVPRLD
                     QGDR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLMGTRKSEQAA"
                     /leader_location="[6349:6388](-)"
                     /alternative_weights="5280.9"
                     /alternative_weights="5299.0"
                     /alternative_weights="5317.0"
                     /alternative_weights="5335.0"
                     /alternative_weights="5353.0"
     gene            6400..6867
                     /locus_tag="HEK616_RS40030"
                     /old_locus_tag="HEK616_81480"
     CDS             6400..6867
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015928.5"
                     /locus_tag="HEK616_RS40030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81480"
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_261958163.1"
                     /transl_table=11
                     /translation="MRLRKCAATSLASVALVAGATAFTSSASAAQRQAAAPHTVQDGGC
                     RTYSGTACFWPNKYGIGTLGEVTDNNSDFTKLYNSTGCKNHNWNDCINSIQNGGTLCTV
                     YFWTGAGYTGRYHSLSLGDAVWDFAAPVSEGGYNDPSFDKSISSNHWCTPR"
     misc_feature    6406..6408
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8024..9241)
                     /locus_tag="HEK616_RS40035"
                     /old_locus_tag="HEK616_81510"
     CDS             complement(8024..9241)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542407.1"
                     /locus_tag="HEK616_RS40035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81510"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_410011392.1"
                     /transl_table=11
                     /translation="MIPVSDQAHASAGPDTAVDESRLEELIIEAQTALPFELPALANRC
                     ASALGLDAALIYLVDLQQQLLIPLDEAMEPLPVDRSSAGWAYRTVSPRVAEADDGMIVW
                     LPLVDGAERLGALAVRTASLDGARMRRSRMLAHLLAMLITSKRAYSDWLAGLARTATMR
                     LPTEMLRAFLPPHTVGSRRCVSTAVLEPAYDVAGDAYDHSVVKDILHTMILDSMGHDLA
                     AGLTTSVAMAAARNARRGGGDLADVVGSVDQALAQWLPDHFCTGVLCRLDAVTGVLQWV
                     NCGHPPPLLIRAKRVLDGVLDSPPQPPIGLVGELAPAARKVHETTLEPGDCVLLYTDGV
                     VEARDADGAEFGLGRFTDFIIRSSAAGQLPAEVLRLLIHAILDYQRNQLRDDATILLFE
                     WRPQHR"
     gene            9500..9961
                     /locus_tag="HEK616_RS40040"
     CDS             9500..9961
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS40040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_261958165.1"
                     /transl_table=11
                     /translation="MNSNSMHSGASWSRRRAAVLTSLLSAVALGWTAVALSVHMTGSPA
                     LDPESVTDADVARLGAAVMAGSAAVAAGLWWRHWATVRRRVTGGGWARAAFVVSAVHSM
                     FVVPVIVFASWEWTALVIAYTCAVFAGGVREAAGVTAPARTSWQPRSAR"
     gene            complement(10001..13195)
                     /locus_tag="HEK616_RS40045"
                     /old_locus_tag="HEK616_81530"
     CDS             complement(10001..13195)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="HEK616_RS40045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81530"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_261958166.1"
                     /sec_met_domain="DUF4135 (E-value: 7.9e-96, bitscore:
                     317.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.8e-53, bitscore:
                     177.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRQRGLTPLDFAAVCQETAEEVRMRFAQPPPWLSKLHGMPLVGT
                     ADAPFPASAPGLPGAQPGHRQDRMARLLGFLSPVLERGIDTLTTGVRDILRSSGSVTDA
                     DRMGELLARTWPRRALTRLVLRVLILELNVARLRGKLTGTDSEARFAEFASWLSDPVRC
                     PLLWESYPLLLRECCATVDAWVAARLEFCSHLCADRELVDEFAPAAGARELTDVAFEAG
                     DGHRGGRSVGILTFSDGGKVVYKPRSLAVDQHFQALLSWANDEGFEPAFPVLRVVGCGD
                     HGWSQCVAPSDCTDPEQVGRFYRRHGGYLALAHALRATDLHFENVIAAGEFPYLVDLEA
                     LFGADLHRAGGSSDEVASALTASTVLATGLLPNPVVSFDDADGGRTDLSGMAYRPGQLT
                     PGKVATWADPATDTMRIVHRRMPMGGSRNTPSLAGRAVLPTDHVTQVTAGFEAMYRILH
                     RRKSELTGPGGMLESFRGDTVRRVLEATETYSAFLWDSYHPNLLRNGVDRDRYLDRTLT
                     RYDSLRVGPSLAASERRQLADGDIPLFTSTVDGRGLTGGEGTVIDDALETTGLQAARDR
                     IMGLSAADMEHQQWVIRSAFACVATEELHSSWPVHTVTTTDHNVAPSALIDHARRIGDK
                     LLASAVRTAEEIGWLGICPSGPSAWRLGPTLSGMYSGAAGIAFFLMHLGLVTGNAGYTE
                     AAADVARSLARRVRRNSDLPPPPAEVPALGLTGEVDGGLYFVAHWSAATGDLGLLADMI
                     DHVLPRLRKTVRRTTASDLVDGLAGTLMALSAAHHVLPSDAVAEVMEQCAEAVVRARTL
                     LTVGAGWAFTAAGDRPLCGMSHGASGIALALARCAQRLGTTRYDEVIQDALRYEDSLVD
                     PERRCWPDLRPASGDRTMTAWCHGAPGIGTARATLAAYGDPGIAKAAAAGLETAVEATL
                     RHYGDAGVVTVRNLSLCHGELGNLDFLATATRGVDNPAARIVTARLTHAVCATLDERGP
                     ICGVPEGLSTPGLMTGIAGIGYGLLRSAAPDRLPDVLSFEPPRPAHLTAGVTGPKTSAD
                     RRNGSARPPSGPGTDD"
     gene            complement(13406..13630)
                     /locus_tag="HEK616_RS40050"
                     /old_locus_tag="HEK616_81540"
     CDS             complement(13406..13630)
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03898.1"
                     /locus_tag="HEK616_RS40050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81540"
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_261958167.1"
                     /transl_table=11
                     /translation="MDTDTIIRAWTDQSFHDSLSEEEIRAIPANPAGEFQEILAFNGTH
                     AIEASTVSIVCITSCMFTFGYTSDNCCAG"
     CDS_motif       complement(13481..13630)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MDTDTIIRAWTDQSFHDSLSEEEIRAIPANPAGEFQEILAFNGTHAIEAS"
                     /locus_tag="HEK616_RS40050_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13406..13480)
                     /prepeptide="core"
                     /locus_tag="HEK616_RS40050_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="2397.8"
                     /monoisotopic_mass="2396.0"
                     /core_sequence="TVSIVCITSCMFTFGYTSDNCCAG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDTDTIIRAWTDQSFHDSLSEEEIRAIPANPAGEFQEILAF
                     NGTHAIEAS"
                     /leader_location="[13480:13630](-)"
                     /alternative_weights="2415.8"
                     /alternative_weights="2433.8"
                     /alternative_weights="2451.8"
     gene            complement(13896..16658)
                     /locus_tag="HEK616_RS40055"
                     /old_locus_tag="HEK616_81550"
     CDS             complement(13896..16658)
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054569.1"
                     /locus_tag="HEK616_RS40055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81550"
                     /product="bifunctional YncE family protein/alkaline
                     phosphatase family protein"
                     /protein_id="WP_261958168.1"
                     /transl_table=11
                     /translation="MQVIRRRRHDGNDRSGALDRRVSRFSRRSALATATAVALAATAGI
                     GYAQTHQFGTAQVGQNTANGQVISSDQYIAPYGDRLVIDNGKIMSSSVSPDGTHIAASL
                     TDGGAALAIVDRENWKVQQLVSASASSNPRISSNSVGQEGPTYSPDGKQLWLGQTDGYT
                     KFTVSPDGSVTNPTFIRIPADGPKRALVGEPVFSSDGSTVYAAVNGQNRVVALDAATGA
                     ITHSWDVGNAPRDMVKVGDKLYVSNEGGRPAKPGDTTINSYNTQVPANPKTGATTTGTV
                     SVIDLAKPDAAVGSIDVGLHPTALYAKGGALFVTNTATNNVSVINTAGDKVVQTIATRP
                     WPEASVGYEPNAVTLTDDGHLLVTLGRANAVAVYRYKSPQEPVSYVGLLPTDYFPSEIA
                     TVGNQVLVSNTRGIDARRPNPSGAHGTHDTTSSLQRFTLPDDSVIRSETAKVFKQNGWM
                     GHSVKKTDGKSDTKPVAVPQRLGAPSTIKHVFLIVKENRTYDQVFGDMPQGNGDAKLAQ
                     FGENVTPNQHALAKQFGLYDNMYDIGTNSAEGHNWLMQSDNPEYTESSAGEYQRSYDTE
                     NDALGHQKSGFLWTGAQAAGKSVKDFGEFQSMESKPSGASWQNLYCDAKTMDATGQRTA
                     YPINTGSAIPSLNDVSVPGFPMFDLDVPDIYKYQIWKQDFEKNGPANLNMFWFSNDHTG
                     GPASPSAQVADNDLAVGKMVDKISHSKYWKNSAIFVVEDDSQAGLDHVDGHRAPIQIIS
                     PWARHGKTDSHYYTQITMIRTIEQILGIHPMNQKDSAASPMSSAFTPYPDTTPFKAQPN
                     RVPLTDGLKTLPPCGPDTPAPQNPQAATVAPAKVPADKQDLAAIWDKWKSKQRLTGPHA
                     VPDYANPAQMNHLTWYETHNWNKPYPGENKIYAPKDVPGAYLPSSENDG"
     gene            complement(16663..18030)
                     /locus_tag="HEK616_RS40060"
                     /old_locus_tag="HEK616_81560"
     CDS             complement(16663..18030)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010359488.1"
                     /locus_tag="HEK616_RS40060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81560"
                     /product="ABC transporter permease"
                     /protein_id="WP_261958169.1"
                     /transl_table=11
                     /translation="MTATLTHAQPHGAGTRRASVARCYRFELVKLVSQWRIRLLVLACW
                     IAPALFVAAVSQQSSLPVDTLFGRWMHATGWAGPLVMLGFAGTWALPLLTSVVAGDVFA
                     AEDRLGTWRHLLVAVRSPRRIFAAKAFASLTVLLLLVAGMACSSAAGGAVAVGNQPLVG
                     LDGHLLTPTDAAVKVLLAWVCVLAPTLALAGIGLLGSVALGRSPMGLLLPVLVALAMQL
                     AQMMPLPVAVRLALPSYAFIAWSGLFTGPAQLAPLLIGIGVSLAWAVLATVLAYLLFLR
                     RDFTNLSYDGSGRRAVTVGVLPLIGLVAVTAAVLTTSITATATGSGIGQDKVQRSVATA
                     FAHLYRMQTEQLHRPAVTEAQLKATATCNKGSLQVAAQGPGNDWRCVVSWHLPGVQAVG
                     QAIYQLDVTPDGRYMADGDGPKEVNGYFLVRTPEGDTPNPLWQFDGNVELLSTSKG"
     gene            complement(18027..18968)
                     /locus_tag="HEK616_RS40065"
                     /old_locus_tag="HEK616_81570"
     CDS             complement(18027..18968)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120903.1"
                     /locus_tag="HEK616_RS40065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81570"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_261958170.1"
                     /transl_table=11
                     /translation="MDALLAVRARGITKCFGDVVALDGVDLEVTQGQIHGLAGPNGAGK
                     TTLLGLLLGLAVADSGSLDMWGTPVRRTLDAPDGVAGFVDGPGLYPSLTARQNLAALAA
                     LRGDDARTTAIDDALAQVGLTDVADDRARGFSLGMRQRLGLAAALLTKPRLLVLDEPSN
                     GLDPAGKKHVHGVLTRLAADGTSVVLSSHRMDDLEALCSDVTILATGRVVFSGPLSKLA
                     PEEQELDYRVRTSDAHAARQLAAETAGIRLVDDTGARYDAKVLVVRAQAAALDQLVVRL
                     VQAGVAVRELSPLVSPLEAAFLALTAPEEAGR"
     gene            19003..19275
                     /locus_tag="HEK616_RS40070"
                     /old_locus_tag="HEK616_81580"
     CDS             19003..19275
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS40070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_81580"
                     /product="hypothetical protein"
                     /protein_id="WP_261958171.1"
                     /transl_table=11
                     /translation="MRGTTMTRCSQLNAHGTVDDRQHRDDARAGTEERRGDKARPGPLP
                     AREIVSSDDSVWFPYLTERLAAVGHRATVPRLPDTAAPEPVASRA"
     gene            complement(19302..20213)
                     /locus_tag="HEK616_RS40075"
                     /old_locus_tag="HEK616_81590"
     CDS             complement(19302..20213)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014172986.1"
                     /locus_tag="HEK616_RS40075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81590"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_261958172.1"
                     /transl_table=11
                     /translation="MLIDAPHRALRFGVKTTPMHLAYDDILRVWEEADELPELDDAWLW
                     DHLMPLAGPPGGAVLEGWTLLAALAARTTRLRLGLLVTSNMLRAPAHLGKIATTVDVIS
                     KGRLIMGLGVGGTRQPDGPNPAVAEYAAYGLPLPSPGEGLARLTETITILRRMWTEEVF
                     DHDGPFTTLRGTRNGPGPVRPGGPPLLLGGWGDRTLRIIAEHADIWNVPGPPHNGTDWI
                     AERARVLDAHCAAIGRDPAEITRSAQIIVDYADPAATRAHVRALAAAGIRHVVLALPRP
                     YPDKAARWLVDEIVTPVRENDA"
     misc_feature    20218..20232
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            20275..20733
                     /locus_tag="HEK616_RS40080"
                     /old_locus_tag="HEK616_81600"
     CDS             20275..20733
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014172985.1"
                     /locus_tag="HEK616_RS40080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81600"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_261958173.1"
                     /transl_table=11
                     /translation="MAENDEGATVEELLGARLGYLLKHAQLRLAEHAGPALAPYGLDAR
                     ELAVLAVLAAGRPLSQLEAARRLGVDRTTMVALVDALEDKGLVERRRSEEDRRRNVVEL
                     TERGKRARADAEDAREAAEREFLAPLGEKDAVRLVKALQVLIRTPDGA"
     gene            20751..20909
                     /locus_tag="HEK616_RS40085"
                     /old_locus_tag="HEK616_81610"
     CDS             20751..20909
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS40085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_81610"
                     /product="hypothetical protein"
                     /protein_id="WP_261958174.1"
                     /transl_table=11
                     /translation="MLSDAVISHPGDWARAAGGLAMEGGLAGELQVHSVERRVAWMRRH
                     LAYADQL"
     CDS             complement(21014..21178)
                     /gene="allorf_0752798_0752962"
                     /locus_tag="allorf_0752798_0752962"
                     /protein_id="allorf_0752798_0752962"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPGRRPPARMAGGPILAGPSAAALIARLRPIRRRPGTPQCSQEPF
                     GQVLGYGRG"
     CDS_motif       complement(21140..21178)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPGRRPPARMAGG"
                     /locus_tag="allorf_0752798_0752962_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21014..21139)
                     /prepeptide="core"
                     /locus_tag="allorf_0752798_0752962_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="4274.9"
                     /monoisotopic_mass="4272.4"
                     /core_sequence="PILAGPSAAALIARLRPIRRRPGTPQCSQEPFGQVLGYGRG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPGRRPPARMAGG"
                     /leader_location="[21139:21178](-)"
                     /alternative_weights="4293.0"
                     /alternative_weights="4311.0"
     gene            complement(21191..>21340)
                     /locus_tag="HEK616_RS40090"
                     /old_locus_tag="HEK616_81620"
                     /pseudo=""
     CDS             complement(21191..>21340)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019767253.1"
                     /locus_tag="HEK616_RS40090"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81620"
                     /product="AAA family ATPase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GWMNTFTDPRLRAAIADPLTRNGAIIETGTGSYRLASTPASTEQR
                     TAAE"
     misc_feature    21658..21671
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.51"
                     /tool="antismash"
     gene            complement(21689..22186)
                     /locus_tag="HEK616_RS40095"
                     /old_locus_tag="HEK616_81630"
     CDS             complement(21689..22186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604214.1"
                     /locus_tag="HEK616_RS40095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_81630"
                     /product="N-acetyltransferase"
                     /protein_id="WP_261958175.1"
                     /transl_table=11
                     /translation="MSWLPDDFVHPVYVPVPDTALHLRPIREADTALDYPAVMGSQERL
                     WEIFGPAWGWPNETMTYEEDRIDLLRHEREIAAHQSFNYALLNEEETALLGCVYIDPPE
                     RTGSDAEVCWWVVDNLAGSEVERALDVLVPQWITADWPFQQPRYLGRDITWQDWLALPR
                     TS"
ORIGIN
        1 gtgaggtcgc cgggcgcagt ggtcgtggcg aggccgagcc ccgactcctc caggcgggcg
       61 aggatggtgt cgagggtcgc cccggtttgc gcggtgacgc tcccgggggt gccgccgcgg
      121 acgctgaccg cggtgaggtg ggaggtggtg tcgacgatga tggtgcggga ggtgtcggcg
      181 ccggcgggta ccaccagcgg tgaccaggtg tggcccttgc ctcgggctcg gagacggtag
      241 ccgtgctcgt gggcccagtt ggcgagggtc accacgtcgt cgggggtacg ggccgaagcg
      301 gtccagacgt cctcgacgcg gatctctaac gaccagttgc gaaaggcctg ttgggagagg
      361 gggatgccgg cggggaagcc gggcggcggg gtgagggtgg ccgcggcgct gcccgcgggg
      421 atgcgatgcg agggctgcag accggctgcc gcggcgagcc ccgcagcggc ggtcgcggtc
      481 aggagcgtgc ggcgggtgag ggaagttctt cgagcgctgt cgtcggacat ggcagtcctt
      541 ccggcacgcg gcgcgccgcc ccgctgcacc gcgcacggga tcgtaggagt gagaccgtac
      601 gagcgccccg gtgcggtggg ggtgcgggga gtgtagggtg acgggccgtc aggtgcaatg
      661 gccatgccat gccacgcctt gcattgacct gcgagtgcag tctccgctcc ttccttcttg
      721 cttggggcct gggccttggg atcacggcgg gggagtgagg tgcggtcgcc gacaggagga
      781 agcgtgggat cgacgggcct cttgcttctc aacacctcct gaatacaaag cggtcagctc
      841 atcgcggtcg gcaggctggc ctacggccgc ggttaaatgg ttagcaactt gcacaaaaca
      901 ccagctaatt gacggtacat cagcggggac ttaccgcgac tctggacaga acccttgacg
      961 cgctattcac acatggtgaa catgcaacga gcaagagagc gctcccatga acgtcatctg
     1021 ttcacttcct gaatccgaat caggagagct tccatgccca caccccccgc agacgcaacc
     1081 gctcaccgca catccagacc ctcacgccgc acagtcctgg ccgcgatggc ggccgcactc
     1141 cccgccgccg gactgcccgt cctgtcctcc cgagcctccg ggacgcccgc tgccgctgcg
     1201 ttgcccggcg gcggcgacct cggcccgaac gtgctggtct tcgaccccgc cacgcccaac
     1261 atccagggca agctcgatga gatcttcaag cagcaggagt cggcccagtt cggcaccgcc
     1321 aggtacgccc tcctgttcaa accaggcacg tacaacggcc tgaacgccca gctcggcttc
     1381 tacacctcga tcgcgggcct ggggctgtcg cccgacgaca cgaccatcaa cggcgatgtg
     1441 accgtcgacg ccggctggtt caacggcaat gcgacgcaga acttctggcg ctcggcggag
     1501 aaccttgcgc tcatccccgt caacggcacg aaccggtggg ccgtcgcgca ggcggcaccc
     1561 ttccgccgga tgcacgtcaa gggcggactg aacctggcac ccgacggcta cggctgggcc
     1621 agcggcgggt acatcgcaga cagccggatc gacggcacgg tcggcccgta ctcccaacag
     1681 cagtggtaca cgcgcgacag ttcggtgggc ggctggcaca acgccgtgtg gaacatggtg
     1741 ttctccgggg tcgagggagc cccggggcag acgtttcccg acccgccgta caccaccctg
     1801 gacaccactc cgatctcgcg cgaaaagccc ttcctctacc tcgcgggcgg cgactaccgg
     1861 gtgttcctcc ccgagaagcg ggtcaacgcc cgcggcacca cctggggcaa cggcacaccg
     1921 cggggcgagt cccttccgct gagccagttc tacgtggcca agcccggcac cgacgcggca
     1981 accctcaacg ccgcactggc ccagggcctc aacttgcttc tcacgcccgg catttaccat
     2041 gtcgaccgac cgatcgaggt gcagcgggcc aacaccgtgg tcctggggct gggatacgcg
     2101 accatcgtgc cggacaacgg ggtgaccgcc atgaaggtcg ccgacgtcga cggggtgcgc
     2161 ctggcggggt tcctcatcga cgccggcccg gtcaactcgg ccacgctgtt ggaggtcggc
     2221 cccgacgggg cttccgcgga ccacgcggcc aatccgacga cggtgcagga cgtcttcgta
     2281 cggatcggcg gcgccggccc cggcaaggcg accaccagca tggtgatcaa cagcaaccac
     2341 accatcatcg atcacacctg ggtctggcgc gccgaccacg gggacggggt gggctgggag
     2401 accaaccgcg ccgactacgg catccgcgtc aacggtgccg acgtcctggc cacagggctg
     2461 ttcgtcgagc acttcaacaa gtacgacgtg gagtggcgcg gcgagcgggg ccgtacggtc
     2521 ttcttccaga acgagaaggc gtacgacgcg cccaatcagg ccgcggtcca gaacggcaac
     2581 accaagggct tcgccgcgta caagatcgcc gacacggtga ccacccacga agggtggggc
     2641 ctgggcagct actgctacta caacgtggat cccaccatcc ggcaggacca cggcttcgag
     2701 gccccgcaca agccgggtgt gaagttccac gatctgctcg tggtctcgct gggcggtaag
     2761 ggccagtacg agcacgtgat caacgacgtc ggcgccgcca cctcgggcac ctcgacggtg
     2821 ccgtccacgg tggtctccta cccctgacca ccacggccta cgaaggccag gcccccggcc
     2881 cgtggccacg tcgccaaggg ccggggatcc ggtgcgcccg aacgggtggc aggtgccgcg
     2941 ctgaccaccg tcgggcgcgc tggggcggga aaggcgatga ggtgagccac ccacttgcag
     3001 cgaacggcag gtaagccatt gtgaaagcgt ttgtcctccg gaaggtcggc gaggtcggcg
     3061 tcatggacaa gccgatcccc gaaccctggg aggcgacctt ccgggtcacg aagccgggcg
     3121 ggcgcatttc caacgtcggg taccacggcg agtcccccga gccgctgcgg atccccctgg
     3181 agccgttcgg atacggcatg tccgacaagc aggtctacgg cgggttcaac cgcggaggca
     3241 gggggtggct tcggcggatc ttccggttga tggagaccgg gaaagtcgat cccacgccga
     3301 tgaccacgca tgagttcggc ttcgacgaga tcgagcgggc attcacgatg atggcctcga
     3361 aggagggagg gatcatcaag ccattgatcc acttcgactc ggcgggcggg taagcgctgc
     3421 tcgtaccgcc tcccggtctc gtcgtctccg ggcggaccct gggtcggccc ccggcgaggc
     3481 cgcggacaac accacttgag ggctgtcagt ggcggtgacc actcggcggg gagtgccgtg
     3541 cgccgaggac ggaggccggg ccgcggcgca cggtacgggt agggcatccc ctcatatggc
     3601 aggtccacct cgcggccctg ccggtgatcc gaacgttgca cgacgagctc atggtcgacg
     3661 cggcacgtat caccggcgca gcccgcgcca agaagatcgc ctgggcgcgg ctagcctccg
     3721 tcctggccac gcgaattgcg cccgccattc cggtacggcg cggtgcttgg gcgaccgtgc
     3781 gaccggggcg gccggggcag gtcagaggcc gccggcgttg agcagccggt tgggggtatc
     3841 ggagcggacg ccgcgcacga caccgcgggt ggccgtgtgg tcgagccaga ggtggacctc
     3901 gttggccgtg gcgtgggggt gtgccgacag gtacagcgcg atcacgccgg tcgcatgggg
     3961 cgcggcccag gacgtcgcgc cgtcattgtc cgtggtcgta ccgccgcccg cgagggcggc
     4021 ggtcaccttc tggccggggg cgtacaggtc cacacaccgt ccgaagcccg atccgtagga
     4081 gccgccgtcg ctccaggcgc ggtcgttcga ggtggaggcc gccacgacga tcgtgccggg
     4141 gacgccggcc ggggagtgct tgcaggcgtc gtcatggaag ttgccggccg acaccaccgt
     4201 cgggatcccc gcgtcgacca tcttcttcac ggcggactcc agggcggctg accggtggtc
     4261 gaggttgagc gacatgttca ccaccgcagg cttctgcgcg tgcgcggtga cccacttgac
     4321 cgacttcacc aaggccgctt cggccgccgc cggggagccg ccgccctcgc tctcacactg
     4381 gatgccctgg acccgtacga gctccgcctt cggcgccacc ccgtatctcg tgccgccgat
     4441 gatgcccgcg acgaaggtgc catggcccat ccccgcctcg ctgaagcagt caccggagtc
     4501 cttcgggccc acgaagtcgg cgccgaggcg cgcccgtccg ccgaactcct tgtgagcgac
     4561 gtccatcccg gtgtcgatca catacacgtg aacgcccttg cccgtggcgg tggtggtgaa
     4621 attcccgttc agcggccgcg accgctggtc cagaatgtcc aggttccacg gcacgtgccg
     4681 ggtgatgggc gacgccgcgg tctgcgcgat accggacgac ttccccacgg tgccgggaga
     4741 caccggcgcc gagccggacg aggccctgcc cccggaggcc atggacgtcc ccttcccgtg
     4801 cgcggggtgc gtttcgccgc ttcctccggc cgcggcgccg gcttccgcgc ggcaggccga
     4861 ggccccgagc accgtcgcca tggccaccac tatgagaccg gccttcgtca cgttccgcgt
     4921 cactacgtcc cccatatccc tgcttcgtac acagtcagcg cacaagacga ccacggaggg
     4981 agggcggttc cggcgggacg ttcacgatcc gcccccagcc ccgatccatg cagcgctgcc
     5041 cctcgcgctc gttgcattcg cctgtgggag gccaagtcgt gcgttctcgt gctgagtcat
     5101 cgggtggccg tcgccgaagt ggtgaggggg tagctggccg ccagctgcgt cgatagcgtt
     5161 gccggatgga tcaagatgaa cggctatgtc acgcctcgtc gttcggtgca gcggcggccg
     5221 catacgctga gcaccgtccg gactacgcgc aggccgcggt gcgttgggcg cttgcacccg
     5281 cgcccggccc acgcgtgctc gacctgggcg ccggcaccgg caagctgacc gccacgctgg
     5341 tcgcgctggg tgccgaagtc gttgcggttg agcccgaccc ggagatgctg gccgagctgc
     5401 gccgctcgct gccggccgtc cgtgccctgt caggtagtgc cgaggcgata ccgctgccgg
     5461 acgcttccgt cgatgccgtg ttggccggca atgccatgca ctggttcgac atggctgtcg
     5521 cggggcccga gatcgccagg gtcctcgcac ccggcggcct cctgggcggc ctgtggaacc
     5581 tcatggacga ccaggtcgag tgggttgccg ggctcgcgcg gatcagcggg agcgcggcca
     5641 tcggcccgcg cgacacgccc accagctggc gcgctgcgac ggcggacatg caccttccga
     5701 agactggcgt ggccgcccgg ttcggctcgc cggagcaggc cgagttcccc cacgggcagc
     5761 gccgcaccgc cgactctctc gtcgcgaccc tcgcgacgcg cgcggggatg ctcgtcatgc
     5821 cggaagagga acgcgaggcc acgctgggcc ggatccgcgc attcctcgcg gggagaccgg
     5881 agaccgccgg cggcgagttc actctcccga tgctgaccgg cgcgctgcgc gtccggcggc
     5941 tgtgaagcat caggtcgaga cccgagtctg accggtccgc ctggcggtgc accgtggtgc
     6001 gagtgtgtgc accgcctggc gcggcgggtg caaggcggcg cccgtagaga gggccggtgt
     6061 cccaggaaga tgtccgtggt gcgtggatcc ggcctggtca ggaggtgggc cgtcccgtgg
     6121 tggtgccaag ggttcgcgag ccgtggtccg ggccggggcg ggccggccat actcgggttg
     6181 tccgacgggg gagggcacgg accttctagc gatccccttg gtccagccgc ggaacggcgt
     6241 aggccggtgt ggatccgaca gcggtacatc gtggtggtga aatccgaaac ctccggcgat
     6301 gacggggatc cggtttcgga accttgggcc tggtgtgccc atgagtctca gcggcctgtt
     6361 cgctcttcct cgttcccatc aacgacacgg gagaacacga tgcggttacg caagtgcgcg
     6421 gcgacgagtc tggcctccgt cgccctcgtc gccggggcca cggcgttcac gtcctcggcc
     6481 tccgccgctc agcgccaggc ggcagcgcca cacactgtcc aggacggcgg ctgcaggacg
     6541 tacagcggca ccgcctgctt ctggcccaac aagtacggca taggcacgct gggcgaggtc
     6601 accgacaaca acagcgattt cacgaagctc tacaacagca ctggctgcaa gaaccacaac
     6661 tggaacgact gcatcaactc catccagaac ggcggcacgc tgtgtacggt ctatttctgg
     6721 accggcgccg gctacaccgg ccgataccac agcttgtccc tcggtgacgc ggtgtgggac
     6781 ttcgcggccc cggtatcgga gggcggctac aacgacccgt cgttcgacaa gtcgatcagt
     6841 tccaaccact ggtgcactcc aaggtgatca gtagagcagc ggcggcgctt ctgacgggat
     6901 gtgccatggc tgcggggctg gtcggctgca cctccgcgca gccgaccggc ccgccggtgt
     6961 ccgccgcgat gacggacgtg gccacgagat cgggccgctg gccaaccggt gcggatcaac
     7021 tccaggccgc cttcgaccag ttggatcgca catgcctgag caaggccggg ttccaccttc
     7081 cggccgcccc gaaggtgacg ttgccgtcac ccgagaacga ggccgccacc atcgacctgg
     7141 ctgcccgcag gcgacgcggt tacggaatat cgatggccca tgacagttcc gccgcggccg
     7201 ggaacccgaa cgcgtacgcg tcctctctgt ccgccgagga ccggcagcgc ttcggaagcg
     7261 cgcagttcgg gccggggatg ccgaggaccg gtgtcgcgtt gaaggggaag gcaacggcca
     7321 ccgttcccac cgccggctgt gtcgcacgtg cgcgtacggc actggccgga gacgtgcaca
     7381 cgtgggctga ggtctcctac ataccccagc agttcgacga ccagaccagt cgcaaggcgc
     7441 tgacggacac cggataccga gccgctcttg tccggtggcg cgcctgtatg gcgcaggccg
     7501 gctacacgta cgcgagcccg gacgccgcgg tggctcgcct gcaactggag cacgagcggg
     7561 gagcgaaggg cgcgcgcttt cagcgccggg agagagcggt ggcagtttcc gacggtgagt
     7621 gtgcgagccg cactcacctg cctgccgagc ttctgcgcgc ccgcaggagg caagtcagca
     7681 ggctctcggc tcgcgacctg tcaacgctgc agtcggttac tcaggactgg gagtcagcgg
     7741 tgacccgcgc ccgccgggta ttggccgctc cagccaagag ggggcctgat tgcggcgcac
     7801 ggcccgcgcg ccggctgctg tgcggcgctg tgcggcgcgg cggggtgggc gacggtgcgg
     7861 atgctcgctc ggcacgttac tgccggacga accgggtggg gtgccggcgc cggcggaggc
     7921 gttcgtcacc gagcagctcg cgatggcccc ggacgtgccg gccgagtgcg cgctccggcc
     7981 gaagacggtg tacgagcaca gcgaggctcg gtgcaccacc gcgtcaccgg tgctgcgggc
     8041 gccactcgaa gagcaggatg gtcgcgtcgt cccgtagttg attgcgctgg taatcgagga
     8101 tggcgtggat gagcagccgc agcacctcgg ccgggagctg accggcggcg gaggagcgga
     8161 tgatgaagtc ggtgaaccgg ccgaggccga actccgcacc gtctgcgtcg cgagcctcta
     8221 cgacaccgtc ggtgtagagc aggacgcagt cgcccggttc cagtgtcgtc tcgtggacct
     8281 tccgggctgc cggggcgagt tctccgacca ggccgatcgg aggctgcggg gggctgtcca
     8341 gcacgccgtc gagcacccgc ttggcacgga tcagcagcgg cggcgggtga ccgcagttga
     8401 cccactgcag taccccggtg accgcgtcga gccggcacag cacgccggtg cagaagtggt
     8461 cgggcagcca ctgggcaagc gcctggtcga cggagccgac gacatcggcc aggtccccac
     8521 cgccgcggcg ggcgttccgt gccgccgcca tggcgaccga ggtggtcaga ccggcggcca
     8581 gatcgtgccc catggagtcg aggatcatgg tgtgcagaat gtccttgacc accgagtggt
     8641 cgtaggcgtc accggcgacg tcgtatgccg gctccaggac cgcggtcgag acgcaccttc
     8701 tgctgccgac ggtgtggggt ggcaggaagg cccgcagcat ctcggtgggc aaccgcatgg
     8761 tggcggtgcg cgcgaggccg gcgagccagt cgctgtaggc gcgcttggag gtgatcagca
     8821 tggcgagcag atgggccagc atgcggctgc ggcgcatccg cgccccgtcg agcgaggcag
     8881 tccgcaccgc cagcgcgccc agccgctccg caccgtcgac cagcggcagc cagacgatca
     8941 tgccgtcatc ggcctcggcc acccgcgggg agaccgtgcg gtacgcccag ccggccgacg
     9001 agcggtccac cggcagtggc tccatggcct cgtcgagcgg gatgagcaac tgttgttgca
     9061 ggtcgacgag gtagatcagc gcagcgtcca ggccgagggc ggaggcgcac cggttcgcca
     9121 gggcgggcag ttcgaacggc agggctgtct gcgcctcgat gatcagttct tccaggcggc
     9181 tctcgtcgac ggctgtgtct ggaccggcgg acgcgtgtgc ttggtccgac acggggatca
     9241 ccccttccgt gcccactctc acaccgatcc caatctctca tgtcaggcat gatcgtgccg
     9301 ggcgccgggt gccgggtgcc gggtgccggg tgcgggctgc ggcgaggggg ggagcggtgg
     9361 ccaggggcgg cgagctgaga ccgacccggg cacacttcgt gcggcggcca tcatgggccg
     9421 gccctcatca gcccccgggg gaatccccgg gggaggctcg tgatcgcgtc cctgttccga
     9481 gcggtggcta gaatgagtca tgaattcgaa ctccatgcat tccggagcca gttggtcccg
     9541 gcggcgcgca gcagttctga cttccttgtt gagcgcggtg gccctcggat ggactgcggt
     9601 cgcactgagc gtgcacatga ccggctcgcc cgcactggac cctgagagcg tgaccgatgc
     9661 tgatgtggcc cggctgggcg ctgccgtgat ggccggcagt gccgcggtgg ccgccggact
     9721 ctggtggcgt cactgggcga ccgtacgtcg gcgggtgacc ggcggaggct gggcgcgggc
     9781 ggcctttgtc gtctccgccg tccattcgat gttcgtcgta ccagtgattg tgtttgcctc
     9841 ctgggagtgg acggcccttg tgatcgcgta cacgtgcgcc gtgttcgccg gcggtgtgcg
     9901 ggaggccgcc ggggtgactg caccagcgcg cacgtcctgg cagcccaggt cggccagatg
     9961 acgggtgatc tcctcggccg tatgcagggt caaagcccgg tcaatcgtcg gtgcctgggc
    10021 ctgatggggg ccgagcgctg ccattgcggc ggtcagcact cgtcttcgga ccggtgacac
    10081 cggccgtcag atgggccggc ctgggcggtt cgaaggagag cacgtcgggg aggcgatcgg
    10141 gggccgcgga acggagcagg ccgtagccga tgcctgcgat gccggtcatc agcccgggag
    10201 tgctgaggcc ttcgggcaca ccgcatatgg gcccgcgttc gtccagggtt gcgcataccg
    10261 cgtgagttag ccgggcggtg acgatccgag ccgcggggtt gtccacgccg cgggtcgccg
    10321 tggcgaggaa gtccagattg cccagctcac catggcacag ggagaggttg cgcacggtga
    10381 cgacaccggc gtcaccgtag tgccgcaagg tggcctccac cgcggtctcg aggccggcgg
    10441 ccgctgcctt cgcgatgccc gggtcgccgt acgcggccag cgtcgcgcgt gcggtcccga
    10501 tccccggtgc gccgtggcac caggccgtca tggtgcgatc cccgcttgcc ggccgtaggt
    10561 cgggccagca tcgccgttcg ggatcgacaa ggctgtcctc gtaccggaga gcgtcctgga
    10621 tgacctcgtc gtagcgagtg gttcccagcc gttgcgcaca gcgggcgagg gccagtgcga
    10681 tgccggacgc cccgtgcgac attccgcaca gcggcctgtc cccggcggcc gtgaaggccc
    10741 agcccgcccc gacggtgagg agggtcctgg ctcggacgac ggcttccgcg cactgctcca
    10801 tcacctcggc gaccgcatcg ctgggcagga cgtgatgcgc ggcgctgagg gccatcagag
    10861 taccggcgag cccgtccacc aggtccgatg ccgtcgtcct gcgcaccgtc ttcctcagcc
    10921 ggggcagcac gtggtcgatc atgtccgcca ggagaccgag gtcaccggtg gctgctgacc
    10981 agtgcgccac gaagtacagc ccgccgtcga cctctccggt caagcccagg gccggcactt
    11041 cggccggggg aggcggcagg tcgctgttgc gtcgtacccg gcgggcgagt gatcgggcca
    11101 cgtcggcggc ggcctcggtg tagccggcgt tgcccgtgac cagcccgagg tgcatcagga
    11161 agaaggcgat cccggccgcg cccgagtaca tgccggacag ggtggggccg agccgccagg
    11221 ccgatggacc ggagggacag atgcccagcc agccgatctc ctccgcggtc cggaccgcgg
    11281 aggccaggag cttgtcaccg atgcggcgcg catggtcgat cagggcgctc ggcgcaacgt
    11341 tgtggtcggt ggtggtgacg gtgtggaccg gccaggacga gtggagttcc tcggttgcca
    11401 cgcaggcgaa tgccgacctg atcacccact gctggtgctc catgtcagcg gcggagagac
    11461 ccatgatgcg atcgcgggcg gcctgcaggc cggtcgtctc caaggcgtca tcaatgaccg
    11521 ttccctcacc cccggtcagg ccgcgcccgt cgacagtgct ggtgaagagg ggtatgtcac
    11581 cgtcagccag ttggcgtcgc tcgctggccg ccaaggacgg accgacgcgc agagagtcgt
    11641 atcgggtgag tgtgcggtcg aggtaccggt ctcgatccac cccgttgcgc agcaggttgg
    11701 ggtgatagct gtcccagagg aaggcgctgt acgtttcggt ggcctccaac acccgtcgaa
    11761 ccgtgtcgcc gcgaaagctc tccagcatcc cgccgggacc ggtgagttcg gatttccgac
    11821 ggtggaggat gcggtacatg gcttcgaagc cggctgtcac ctgtgtgacg tgatcggtgg
    11881 ggaggacggc ccggcccgcg agtgaagggg tgttccggga cccgcccatc ggcatccggc
    11941 ggtggacgat acgcatcgtg tccgtggcgg gatccgccca ggtcgccact ttgccgggcg
    12001 tcaactggcc ggggcggtag gccatgccgg acaggtctgt gcgtccgccg tcagcgtcat
    12061 cgaacgacac gaccgggttg gggagcagac cggttgccag cacggtcgag gcggtgagtg
    12121 cggaggcgac ctcgtcactg ctgccgcccg cacggtgcag gtcggcgccg aacagcgcct
    12181 cgaggtcgac caggtaggga aactcgccgg ccgctatcac gttctcgaag tgcagatccg
    12241 tcgcgcgcag ggcatgtgcg agggcgaggt agccaccgtg ccggcggtag aaacgcccga
    12301 cctgctcagg atcggtgcag tccgatggcg cgacgcattg cgaccacccg tggtcgccgc
    12361 agccgaccac ccgcaacacc gggaaggccg gttcgaaccc ttcatcgttc gcccagctca
    12421 gcagagcctg gaagtgctgg tcgacggcga gcgagcgggg cttgtagacc acctttcccc
    12481 cgtcggagaa ggtcaggatg ccgaccgaac gcccgccgcg atgcccgtct ccggcttcga
    12541 acgccacatc ggtcagttcc ctcgcgccgg cggccggtgc gaactcgtcg accaactccc
    12601 gatccgcgca caggtgggaa cagaattcca gccgagcggc gacccaggca tcgacggtgg
    12661 cacagcactc cctgagcagg agcgggtagc tctcccacag caacgggcag cggacgggat
    12721 cggaaagcca ggaagcgaac tcggcgaacc gcgcctcgct gtcggtgccg gtgagcttcc
    12781 ctcgcaaccg tgccacgttg agctcgagga tcaacacgcg cagcaccaag cgagtcaggg
    12841 cccgccgggg ccaggtgcgg gccagtagtt cacccatccg gtcagcgtct gtcaccgagc
    12901 cggaggagcg caggatgtcc cgcacaccgg tggtgagagt gtcgattccg cgctccaaga
    12961 cgggggagag gaagccgagg aggcgggcca ttcggtcctg ccggtggccg ggttgagcgc
    13021 cgggcaagcc gggcgccgac gccgggaacg gggcgtcagc ggttcccacc agcggcattc
    13081 cgtgcagctt cgacaaccac ggcggaggct gcgcgaagcg catgcgtact tcttccgcgg
    13141 tctcctggca caccgctgcg aagtccagtg gggtcaggcc tcgctgccgc agcatgcggg
    13201 tgaacagttc gtcatcggaa tacgggaact gctcgcggag ggcatccagc ctcctggctg
    13261 cggcagcgtg gcccgcgtcg ccgagggcag cgctgccggc agcgactcgt tcgtccaggc
    13321 gggttgccag ataccagtgg ctcgcgcggg cgtcgagacg aacaggcggg ccggaatacg
    13381 acgcggacac gggagcgcaa ctccgctagc cggcacagca gttgtcggag gtgtacccga
    13441 aggtgaacat gcacgacgtg atacagacga tggacaccgt gctggcttcg atcgcgtgcg
    13501 tgccgttgaa ggcgaggatc tcctggaact ccccggcggg gttggccggg atggcgcgga
    13561 tctcctcctc ggacaaggag tcgtggaagc tctgatcggt ccaggcgcgg atgatggtgt
    13621 ctgtgtccat ggatatcgac atgctgccct ctctcgatgg ccggcgttcg ttgtcgccca
    13681 gtagtgtcat cggaggcagt ccggggagtc attgaccgga agcgcacacc cgttgactgc
    13741 ggacgcacgc cgtcgacccg ccagctttcc acgtgcggcg gtcagaagaa ggcgacccga
    13801 cggcccggag cggctgcgtt ccgcgctgat cgcggcccgg accgctcagg tccaggccgc
    13861 ggtgaagcca gtcgctcctc agtctccggc agacatcagc cgtcgttctc ggaggaagga
    13921 aggtacgccc ccggcacatc cttcggcgcg tagatcttgt tctcgcccgg gtacggcttg
    13981 ttccagttgt gcgtctcgta ccaggtgagg tggttcatct gggcggggtt ggcgtagtcg
    14041 gggacggcgt gggggccggt cagccgctgc ttggacttcc acttgtccca gattgccgcc
    14101 aggtcctgct tgtccgcggg taccttcgcg ggcgcgacgg tcgctgcttg ggggttctgt
    14161 ggtgccgggg tgtccgggcc gcagggcggc agggtcttca ggccgtcggt gagcgggacg
    14221 cggttgggct gcgccttgaa cggggtggtg tccgggtagg gggtgaaggc gctgctcatg
    14281 gggctggccg cgctgtcctt ctggttcatc gggtggatcc cgaggatctg ctcgatggtc
    14341 cggatcatcg tgatctgggt gtagtagtgg ctgtcggtct tgccgtgccg tgcccagggg
    14401 ctgatgatct ggatcggggc ccggtgcccg tcgacgtggt cgaggccggc ctgggagtcg
    14461 tcctcgacga cgaagatggc cgagttcttc cagtacttgc tgtgcgagat cttgtcgacc
    14521 atcttgccga ccgcgaggtc gttgtccgcg acctgggcgg acgggctcgc gggaccaccg
    14581 gtgtggtcgt tggagaacca gaacatgttc aggttcgccg gcccgttctt ctcgaagtcc
    14641 tgtttccaga tctggtactt gtagatgtcc gggacgtcga ggtcgaacat cgggaagccg
    14701 ggcaccgaca cgtcgttgag cgaggggatc gccgacccgg tgttgatggg gtaggccgtg
    14761 cgctgaccgg ttgcgtccat ggtcttggcg tcgcagtaca ggttctgcca ggacgctccg
    14821 gacggcttgc tctccatcga ctggaactca ccgaagtcct tgacggactt gcccgccgcc
    14881 tgcgcaccgg tccacaggaa accggacttc tggtggccaa gagcgtcgtt ctcggtgtcg
    14941 tagctgcgct ggtactcacc ggccgaggac tcggtgtact ccggattgtc gctctgcatc
    15001 agccagttgt ggccctcggc ggagttcgtg ccgatgtcgt acatgttgtc gtacagcccg
    15061 aactgcttgg ccagcgcgtg ctggttcggc gtcacgttct cgccgaactg cgccagcttc
    15121 gcatcgccgt tgccctgtgg catgtcgccg aagacctggt cgtaggtccg gttctccttg
    15181 acgatcagga agacgtgctt gatcgtcgag ggggcgccga gccgctgcgg gaccgctacc
    15241 ggcttcgtgt cgctcttgcc gtcggtcttc ttgaccgagt ggcccatcca gccgttctgc
    15301 ttgaagacct tggccgtctc ggacctgatg acgctgtcgt ccggcagggt gaaccgctgc
    15361 aggctggagg tggtgtcgtg ggtgccgtgc gcgccgctgg ggttgggacg acgggcatcg
    15421 ataccacggg tgttggagac cagtacctgg ttgccgaccg tggcgatctc cgaggggaag
    15481 tagtccgtgg ggagcagacc gacgtaactg accggctcct gcgggctctt gtacctgtac
    15541 acggcgaccg cgttggcgcg gccgagcgtc accagcagat gaccgtcgtc ggtgagcgtc
    15601 accgcgttgg gctcgtaacc caccgacgcc tccggccacg gccgggtggc gatggtctgc
    15661 acgaccttgt cgccggcggt gttgatgacg gacacgttgt tggtggcggt gttggtgacg
    15721 aacagtgccc cgcccttggc gtacagggcg gtcgggtgca gaccgacgtc gatgctcccg
    15781 acggcggcat ccggcttcgc caggtcgatg acgctgaccg tgccggtggt agtggcaccg
    15841 gtcttcgggt tggcaggcac ctgggtgttg taggagttga tcgtggtgtc gccgggcttg
    15901 gccggacggc cgccctcgtt gctgacgtag agcttgtcgc cgaccttgac catgtcacgc
    15961 ggggcgttgc ccacgtccca gctgtgtgtg atggccccgg tcgccgcatc gagggcaacg
    16021 accctgttct ggccgttgac cgcggcgtac acggtggagc cgtcggacga gaacaccggc
    16081 tcgcccacca gcgcgcgctt gggtccgtcc gccgggatcc ggatgaacgt cgggttggtg
    16141 acgctgccgt ccgggctcac ggtgaacttg gtgtagccgt cggtctggcc cagccacagc
    16201 tgcttgccgt cgggcgagta cgtggggcct tcctggccca cggagttgct gctgatgcgc
    16261 gggttcgacg atgcggaggc gctgacgagc tgctgcacct tccagttctc gcggtcgacg
    16321 atggccagcg ccgctccgcc gtcggtcagc gaggctgcga tgtgggtgcc gtccgggctg
    16381 accgaggacg acatgatctt gccgttgtcg atgacgaggc ggtcgccgta cggggcgatg
    16441 tactggtcgc tggagatgac ctggccgttt gccgtgttct ggccgacctg ggcggtgccg
    16501 aactggtgcg tttgggcata gccgatgccg gcggtggcgg cgagggcgac cgcggtggcc
    16561 gttgccaggg cactgcggcg gctgaagcgg ctgacgcgtc tgtcgagagc gccggaacgg
    16621 tcgttcccgt catgccgacg gcggcgtatg acctgcatgg agtcatccct tcgaggtgga
    16681 gagaagttcg acattgccgt cgaactgcca caacgggttc ggtgtgtccc cctccggggt
    16741 ccgcaccagg aagtagccgt tgacttcctt cggtccatcg ccatcggcca tgtaccgccc
    16801 gtccggggtc acgtcgagct gatagatggc ctgccccacg gcctggacgc cggggagatg
    16861 ccaggagacg acgcagcgcc agtcgttgcc cggtccctgc gcggcgacct ggaggctgcc
    16921 cttgttgcac gtcgccgtgg ctttcagctg ggcctcggtg acggcgggcc ggtggagttg
    16981 ctcggtctgc atgcggtaca ggtgggcgaa tgccgtggcg accgagcgtt gcaccttgtc
    17041 ctgcccgatc ccggagccgg tcgccgtggc cgtgatcgac gtggtgagga ccgccgccgt
    17101 cacggcgacc agcccgatca gcggcagcac tccgacggtg accgcgcggc gccccgagcc
    17161 gtcgtagctc aggttcgtga agtcgcgccg caggaacagc agataggcca gcactgtcgc
    17221 cagcacggcc catgccaggc tgacaccgat gccgatcagg agcggggcga gctgggccgg
    17281 gccggtgaac agaccgctcc aggcgatgaa ggcgtagctg ggcagggcga ggcgtacggc
    17341 gacgggcagt ggcatcatct gggcgagctg catcgcgagg gcgacgagca cgggcagcag
    17401 cagtcccatc ggggagcgcc ccagggcgac ggagccgagc agtccgattc cggcgagggc
    17461 gagtgtcgga gcgaggacgc agacccaggc gagcaggacc ttgacggcgg cgtccgtcgg
    17521 cgtcagcagg tggccgtcga ggccgaccag tggctggttg ccgaccgcca cggctccacc
    17581 ggccgcgctg gaacaggcca ttccggccac gagcagcagg aggacggtga ggctggcgaa
    17641 cgccttcgcg gcgaagatcc gcctggggga ccggaccgcc acgagcaggt ggcgccaggt
    17701 gccgagtcgg tcctcggccg cgaagacgtc gccggcgacc accgaggtca gcagcggaag
    17761 cgcccaggtg cccgcgaaac cgagcatcac cagcggtccg gcccatcccg tggcgtgcat
    17821 ccagcggccg aaaagggtgt cgacggggag cgagctctgt tggctcaccg cggcgacgaa
    17881 gagcgccggc gcgatccagc aggcgagaac cagcaggcgg atccgccact gcgagaccag
    17941 cttgaccagc tcgaagcggt agcaacgcgc caccgaggcg cggcgggtac cggcaccgtg
    18001 gggctgggcg tgggtgaggg tggcggtcat cgtccggcct cctcaggtgc ggtgagggcg
    18061 aggaacgctg cctcgagcgg cgataccagg ggggagagct cgcgtactgc gacgcccgcc
    18121 tgcaccagcc gcaccaccag ttggtcgagg gcagcggcct gcgcgcgtac gacgagtacc
    18181 ttcgcgtcgt atcgcgcccc ggtatcgtcg acaaggcgga tcccggccgt ttcggcagcc
    18241 agttggcggg cggcgtgcgc gtcggaggtg cgtacccggt agtcgagttc ctgctcctcg
    18301 ggggccagct tgctcagcgg cccggagaag acgacccgcc cggtggcgag gatggtgacg
    18361 tcggagcaca gggcctcgag gtcgtccatg cggtgactgg agagcacgac gctggtgccg
    18421 tccgccgcga gccgggtcag gacaccgtgt acgtgctttt tgccggccgg gtccaggccg
    18481 ttggacggct cgtcaagcac cagcagccgg ggcttggtga gcagcgccgc ggccagcccc
    18541 aaccgctgtc gcatgccgag ggagaagccg cgggcccgat cgtcggcgac atcggtgagc
    18601 ccgacctgcg caagcgcgtc gtcgatcgcc gtcgtccgtg cgtcgtcacc gcggagcgcg
    18661 gccagcgcgg cgaggttctg ccgggcggtg agcgaggggt agagaccggg tccgtccacg
    18721 aagcccgcga ctccgtcggg cgcgtcgagc gtccgtcgga ccggtgtacc ccacatgtcg
    18781 agactgccgc tgtcggcgac ggccagaccc agcaggaggc cgagcaaggt cgtcttgccg
    18841 gcgccgttcg gtccggccag gccgtgaatc tgcccctgcg tcacctccag gtcgacgccg
    18901 tcgagcgcga cgacatctcc gaagcacttg gtgatcccgc gagcccggac tgcgaggagt
    18961 gcgtccatga gtcccttcct tcgaaagcct caaggaccgt agatgcgcgg cacaacgatg
    19021 accagatgca gtcagttgaa tgctcatgga actgttgacg accggcagca ccgcgacgat
    19081 gcccgggcgg gcaccgagga gcgccggggt gacaaggccc gccccggccc gctgcccgcc
    19141 cgagagatcg tgtccagcga cgacagcgtc tggttcccgt acctgaccga acgactggcg
    19201 gccgtgggac accgggccac cgtgccccgc ctgccggaca ccgccgctcc ggagcctgtc
    19261 gcgagcaggg cgtgatgcgc agccgtgtaa tgcaggcacc gtcaagcgtc gttctcccgg
    19321 acaggggtga cgatctcgtc gacgagccag cgggccgcct tgtccggata gggacggggc
    19381 agcgcgagca cgacgtgccg gatgccggcg gcggcgagtg cacggacgtg ggcgcgggtg
    19441 gcggcggggt cggcgtagtc gacgatgatc tgcgcggatc gggtgatttc ggcggggtcg
    19501 cggccgatcg ccgcgcagtg cgcgtccagg acgcgggcgc gttcggcgat ccagtcggtg
    19561 ccgttgtggg gcgggccggg gacgttccag atgtcggcgt gctcggcgat gatgcgcagt
    19621 gtgcggtcgc cccagccgcc gagcagcagc ggtgggccgc cgggtcggac cgggccgggg
    19681 ccgttgcggg tgccgcgcag ggtggtgaag gggccgtcgt gatcgaagac ctcctcggtc
    19741 cacatgcggc gcaggatggt gatcgtctcg gtgaggcggg ccaggccctc accgggactc
    19801 gggagcggga ggccgtaggc ggcgtactcg gcgacggccg gattggggcc gtcgggctgt
    19861 cgggtgccgc caacgcccag gcccatgatc aggcgccctt tggagatcac gtccacggtg
    19921 gtggcgatct ttccgaggtg ggcgggggcg cgcagcatgt tgctggtgac gagcagaccg
    19981 agtcggagtc gtgtggtgcg cgcggccagt gcggccagga gcgtccagcc ctccaggaca
    20041 gcgccgccgg gcggcccggc cagcggcatc aggtggtccc acagccaggc gtcgtcgagt
    20101 tcgggtagtt cgtcggcctc ctcccagacg cggaggatgt cgtcgtaggc caggtgcatg
    20161 ggcgtcgtct tgacgccgaa gcggagcgcg cggtgcggtg cgtcaatgag catagccatc
    20221 agggtagttg atcgtcagct gtcctgacta tcaggcgatg gctaagattt tgggatggcg
    20281 gagaatgatg aaggggccac ggtcgaggag ctgctcggcg cgcggctggg ctacctgctg
    20341 aagcacgcgc agctgcggct ggccgagcat gccgggcccg cacttgcccc gtacgggctg
    20401 gatgcacggg agttggcggt gctcgcggtg ctggcggcgg gtcgtccgct gtcgcaactg
    20461 gaggccgcgc ggcggctggg cgtggaccgc acgacgatgg tcgcgctcgt cgacgcgctg
    20521 gaggacaagg ggttggtgga gcggcgccgc agcgaagagg accgccgccg caatgtcgtt
    20581 gagttgacgg agcggggcaa acgggcgcgg gccgatgcgg aggacgcccg cgaggcggcg
    20641 gaacgagagt ttctcgcccc actcggcgag aaggacgcgg tgcgcctggt gaaggcgttg
    20701 caggtgctga tcagaactcc ggacggggcc tgaaggccct cggtgagctg atgctcagcg
    20761 acgcggtgat ctcacacccc ggcgactggg ctcgcgcggc cggcggactc gccatggagg
    20821 gcgggttggc cggcgagctc caggtgcact ccgtggagcg tcgcgtggcg tggatgcgga
    20881 ggcacctggc ctacgccgac cagctgtagg agcaactggc cggctggtac cggcaggccg
    20941 gcgatgacaa cgccgccgac acgtccagcc ggccgaacag cgtcccggcc aacaccactg
    21001 ggagggtggt cagttacccc ctcccgtacc ccaggacctg cccgaatggt tcctgcgagc
    21061 actgcggcgt ccccggccta cgccgtattg gccgaagacg ggcgatgagt gccgcggctg
    21121 acggcccggc caggatgggg ccgcctgcca tcctggctgg tggacggcgg cccggcacgc
    21181 gccgttcaag tcattcggca gcagtgcgct gttccgtgct ggctggggtg ctggcgagcc
    21241 ggtaggagcc ggtgcccgtc tcgatgatcg cgccgttgcg ggtgagcggg tcggcgatgg
    21301 ccgcgcggag acggggatcg gtgaaggtgt tcatccaccc atctggggcc ggcacttgtt
    21361 ccctcacgag agtcgctgct gcgacctgcc cgtatccgtt cctgaggtcc tcgttggatc
    21421 tctcgatagc accccggttc tcaaggcgct gcaagcgcga ggccggccgc ccgggccaga
    21481 tgttcgagct ctgatcacat ggtgctgctg ccgagcccct ccgatcgggt cgatcccctt
    21541 ccgttgaccg cgccatcggc cgccgcggtg cggcgaccgg tcggggagca gcggctcgat
    21601 tcatgtccac tgggcatccg tcaacggcag atccacgcaa cgatcaggcg ttcttgaagg
    21661 acctgatcca agagccgtct cgggtgtgtc acgaggtgcg cggcagtgcg agccagtcct
    21721 gccaggtaat gtcgcggccc aggtaacggg gctgctggaa gggccagtca gcggtgatcc
    21781 actgcgggac cagcacgtcg agcgcgcgct ccacttcgct gccggcgagg ttgtccacca
    21841 cccaccagca gacttctgcg tcggagccgg tgcgctcggg cgggtcgatg tagacgcagc
    21901 cgaggagcgc cgtctcttcc tcgttgagca gcgcgtagtt gaacgactgg tgcgcggcta
    21961 tctccctttc gtgccgcagc aagtcgatgc ggtcctcttc ataggtcatt gtctcgttgg
    22021 gccagcccca ggccgggccg aagatctccc acaggcgttc ttgggagccc atcacggcgg
    22081 ggtagtcgag cgcggtgtcc gcttcccgga taggccgcag gtgaagcgcg gtgtcgggca
    22141 cgggcacgta gacggggtgg acgaaatcgt caggcagcca actcataagg cccgaggcta
    22201 cagccggttg gcgcgggatg atccggtcgg aaggggcgtc acggcggacg caaccgaact
    22261 tcgacaagac cgtccgcatc taccaagccg cctgtacagc gcccgcccga tacatcgcag
    22321 agatcttcct ctggaccaag tgatccaatg gacgggatcg tgcgctggca gtgctgcgtt
    22381 gggcccgtgt ggcgatcgac gtgcccagcg tgtgaccatg cccggagcgc gctccgaaaa
    22441 cggcgggttc cttcccgcct cccctccacc cttgcgaatg gcacgggcac actcgtgggt
    22501 cggggcccgc cgtcccgtca ttcaccgtgg ttgtggtggt cgggcgccga cgccacgacg
    22561 gcgggcgtcg gccgctgtgg gcagtccttc ctgcggagag aagctcactt ctgtgagcct
    22621 gcagctgtgg tcgtctggac gggcggatgg tgaggcagct ggggcggaac cggcttgcgc
    22681 cctgtctcac cccgaggtgc ctggtgtgcc ggctcccgct ggtggcaccg caggcctggt
    22741 cgcactctgc cagagggcta tgtgaaggtg atgcttgccg cttccgtgat gactacgccc
    22801 tgatagggaa ctcggccgca cacgtcggaa gtggctctga gtctgtgttg cgtcaccgac
    22861 ggctgcggag tgatcggtac cacagtgccg ggtcgtactt tcctctcgtg ttaacctcaa
    22921 acgtttgcac ggccgtgccg gctggccatt ctgcccagcc ggttcccttg ttcgtcggct
    22981 gctcattcct gccgggcctt cctcggtacg ttccccatgc ggaaggctct tcatgaatca
    23041 cccggaccgc ctcggcacct cgcacggcga ccttgcccgg ccagttcccc tcaccccgac
    23101 gatgtcgccg gtcgcctcct tcgccgacct ggaactgccg gccgaggtgc tgcgaacgct
    23161 caccgagctc ggcctgcgcg agcccttccc gatcc
//
