LOCUS       NZ_AP026074            20720 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 plasmid SNP1.
ACCESSION   NZ_AP026074
VERSION     NZ_AP026074.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1073703)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 556932
            Orig. end                         :: 577652
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026074.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20720
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="7"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20720
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20720
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10720](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10720
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            739..1566
                     /locus_tag="HEK616_RS39095"
                     /old_locus_tag="HEK616_79530"
     CDS             739..1566
                     /NRPS_PKS="Domain: Abhydrolase_1 (29-144). E-value:
                     4.4e-23. Score: 74.1. Matches aSDomain:
                     nrpspksdomains_HEK616_RS39095_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981951.1"
                     /locus_tag="HEK616_RS39095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79530"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_261957993.1"
                     /sec_met_domain="PF00561 (E-value: 9.5e-19, bitscore: 63.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.2e-19, bitscore:
                     64.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPNTPTPIGRYFHVNDGRIYGHVREGEGPALIFLHYWGGSHRTW
                     RPVIEHLSPTQGFVSHDHRGWGESTEVPGPYGIEQLADDTERVIDELGYGEYVVVGHSM
                     GGKVAQVLASRRPTGLAGVVLVAPAPPAPVGVTPEFQEALAHAYDTDETIGRSIDLVLT
                     HRELSAQARRQIHEDSARAGEAARMAWPRQALVEDFTDRVGAIDVPVLVLAGSDDKVDP
                     PHILREHLLPAIPTATLTELSGTGHLSPLEVPDQVAAHIGRFVARLSTVVERG"
     aSDomain        826..1170
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS39095_Abhydrolase_1.1"
                     /evalue="4.40E-23"
                     /label="HEK616_RS39095_Abhydrolase_1.1"
                     /locus_tag="HEK616_RS39095"
                     /protein_end="144"
                     /protein_start="29"
                     /score="74.1"
                     /tool="antismash"
                     /translation="PALIFLHYWGGSHRTWRPVIEHLSPTQGFVSHDHRGWGESTEVPG
                     PYGIEQLADDTERVIDELGYGEYVVVGHSMGGKVAQVLASRRPTGLAGVVLVAPAPPAP
                     VGVTPEFQEAL"
     CDS_motif       1021..1080
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEK616_RS39095_0001"
                     /evalue="6.40E-06"
                     /label="NRPS-te1"
                     /locus_tag="HEK616_RS39095"
                     /protein_end="114"
                     /protein_start="94"
                     /score="18.7"
                     /tool="antismash"
                     /translation="GEYVVVGHSMGGKVAQVLAS"
     gene            complement(1757..2155)
                     /locus_tag="HEK616_RS39100"
                     /old_locus_tag="HEK616_79540"
     CDS             complement(1757..2155)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015663004.1"
                     /locus_tag="HEK616_RS39100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79540"
                     /product="VOC family protein"
                     /protein_id="WP_261957994.1"
                     /transl_table=11
                     /translation="MDFVSIRIITSDVARLVEFYERATDVQATWATEDFAELRTPTATL
                     AIASTRTVPLFAPGSARPADNHSVITEFLVADVDRVHQNLTAFITDFVSEPTTMPWGNR
                     SLLFRDPDGNLVNFFTPVTPAAIAKFAR"
     gene            2248..3237
                     /locus_tag="HEK616_RS39105"
                     /old_locus_tag="HEK616_79550"
     CDS             2248..3237
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122373.1"
                     /locus_tag="HEK616_RS39105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79550"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_261957995.1"
                     /transl_table=11
                     /translation="MPRPTGRVLTLLELLQSGGTRTMSELAERLGVDGRTVRRYVDHLI
                     DLDVPVESVRGRYGGYRLAPGYRLPPLMLSDDEALVVLLGLVAGRRTGLMTAGHTASET
                     ASAKIRRVLPQHVARRLDMLLESLAFTDQPGEFAAPDAGVLLTLADAVRHRRPVSMRYT
                     DGGGRRSERTLHAYGIVAHSGRWYVTGQDAQRGEDRTFRLDRIADARTLPGSFEPPVDS
                     GPAERVLSGFATAEYRHEVTLRIHGTVEQIRAHLPAGVASLEEHEPAVDDDRVTERWLR
                     VQLRAERLDWLPPVLAALDRPFVIERPDELRELVTTFAERLASYARQA"
     misc_feature    3267..3280
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.35"
                     /tool="antismash"
     gene            3393..4037
                     /locus_tag="HEK616_RS39110"
                     /old_locus_tag="HEK616_79560"
     CDS             3393..4037
                     /EC_number="2.1.1.77"
                     /GO_function="GO:0004719 - protein-L-isoaspartate
                     (D-aspartate) O-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827956.1"
                     /locus_tag="HEK616_RS39110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79560"
                     /product="protein-L-isoaspartate(D-aspartate)
                     O-methyltransferase"
                     /protein_id="WP_261957996.1"
                     /sec_met_domain="PCMT (E-value: 2.2e-53, bitscore: 177.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEATPSPEDLVQAVRAVGVRDERLLEAVRATPRAAFVPHGHQAH
                     AYEDAPLPIAHGQVTTQPSLSALMIEGLEVSGDAHILEVGTGLGFQTALLARLAGDVVT
                     IEMWPELAHQARRNLDRQGIRNVELHIGDGSGGVPVRAPYDAVIVSAAFPEVPAPLVEQ
                     LRPGGRLVQPIGPGGREQVMSFVRTATGLERCRVLTPAHFVRLRGRYGFSS"
     gene            4139..5308
                     /locus_tag="HEK616_RS39115"
                     /old_locus_tag="HEK616_79570"
     CDS             4139..5308
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540747.1"
                     /locus_tag="HEK616_RS39115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79570"
                     /product="sensor histidine kinase"
                     /protein_id="WP_261957997.1"
                     /transl_table=11
                     /translation="MDRSSRQPDDAFAGEARGELSPRAARALWWGSAGLVLAVLGTSVL
                     VAGAGHGWRLPVAGALVLAQACALRWLGRAPVAVLAATAATGLAVWALLPAVTLTGALL
                     AAQVALCVLSAIRPRRVSVRALAAMCLPAPLAFGAGGPAGLTVYLLTVVLAWTVGQWRR
                     AQQARTRAEMRRAVVEERARIAREVHDVVAHTLSVMVIQASAADDVFGERPDQARQALR
                     AIETGARSALGELRLLLRAFGPGAGEEESGEQREPGPSLARLDELIDTVRATGMTVYVD
                     RAGTIEGLPAAVDLAAYRIVQEALTNTLRHAAGADEVSVRVTAEGECVKVTVVDNGRTT
                     QGSWAVVGAGRGLMGMEERARLVGGSLHAGRLPGGGFEVAAELPVEGAS"
     gene            5305..5964
                     /locus_tag="HEK616_RS39120"
                     /old_locus_tag="HEK616_79580"
     CDS             5305..5964
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540746.1"
                     /locus_tag="HEK616_RS39120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79580"
                     /product="response regulator"
                     /protein_id="WP_261957998.1"
                     /transl_table=11
                     /translation="MTLRVVVADDQVLVRTGFRMIIDAREDLEVVGEASDGQEAVRLTR
                     ELAPDVVLMDVRMPVVDGIEATRQIVEYGSRARVLVLTTWDVDAHVVAALRAGASGFLL
                     KDIRPTELVDAIRLTARGDALLAPTVLSRVLDRFLRTTPDPAPPPSLQDLSGREREVLT
                     LIGQALSNAEIAERLRLSEATVKNHVTAVLRKLGLRDRVQAVVAAYDHGLVQPRRP"
     gene            6123..6761
                     /locus_tag="HEK616_RS39125"
                     /old_locus_tag="HEK616_79590"
     CDS             6123..6761
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677149.1"
                     /locus_tag="HEK616_RS39125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79590"
                     /product="GOLPH3/VPS74 family protein"
                     /protein_id="WP_261957999.1"
                     /transl_table=11
                     /translation="MNDDLACLMYLLAHDDAAEGPYDRSRTELLVRAAALIDLALRGRL
                     GETGGTVTVSGTEPTGDPVLDGVLRDATAGHGWKHLMRRHRKRTLTEVEDRLAAAGLLT
                     VQTPPTRFGTRRLTVADRAVPAALHARVSAVLHGDGPVQEIPTADAALLALAAAGGIRS
                     VVSRQDQNLFRARIDACTGSLAALAPGLEKAVRTLPMTMIAAQGGMGGS"
     gene            6788..8380
                     /locus_tag="HEK616_RS39130"
                     /old_locus_tag="HEK616_79600"
     CDS             6788..8380
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677150.1"
                     /locus_tag="HEK616_RS39130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79600"
                     /product="carboxylesterase/lipase family protein"
                     /protein_id="WP_410011406.1"
                     /transl_table=11
                     /translation="MSMHRVLTTLGCALTAVVATAWSAALPSQPVRPAATTVRTTEPAA
                     TTVRTHDGPVRGATHDGYRTFEGIPYAAPPVGRLRWTPPRHPAPWSGVRDATRPAGACP
                     QPAGEVPGGSTDEDCLHLNVTTPDGAGPARPRPVIVWLHGGGFTTGAGSSYDAHRLATR
                     GDVVVVTVNYRLGALGFLAHRGLPGSGTFGLADQQAALRWVRAEIGAFGGDAHNVTLAG
                     ESAGGYSVCAQLASPAAAGLFDRAIIQSGPCTGRSDRPFAPSSVPLSTARAAGADLATK
                     VGCGSTREVMACLRRVHVSRLLAHQGIDQQPSYATPLLPGDPAAAIAAGRFPRVPVLLG
                     NNHDEGNGWAAGIVQAGHPVTPDTWPGVVASFFPAPGRTKAIVREYPVHRTDGGPVFGA
                     VIGDANFACPTARTEDLLASQVPVWRYEFADEHAPPLTPGTPPFPPGAPHASELPYLFD
                     LGGRPRHLTAAQHRLANTMIDYWARFARTADPNGPSSPHWPRQTVLSLAPDHIVPTRTT
                     RARHHCAFWNALG"
     gene            8879..9604
                     /locus_tag="HEK616_RS39135"
                     /old_locus_tag="HEK616_79610"
     CDS             8879..9604
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008715 - CDP-diacylglycerol diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014650.5"
                     /locus_tag="HEK616_RS39135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79610"
                     /product="CDP-diacylglycerol diphosphatase"
                     /protein_id="WP_261958001.1"
                     /transl_table=11
                     /translation="MTAKYGERTLSSTPDPLLCGSSTDDDTLWKMAWQCQERPKGSRWL
                     VAKGQQGHLLVPTDRIRGIECPDLVSGAYSDKDHNYWQVAWDRAYDWFSKPPWGTFGLG
                     INAAGSRSQDQLHIHMSLVVQGVTADLNNASGAVAKDFDHWPYCLVTVNGWDNQKKQRD
                     PRSYRVVHTNTLDFNLFAALHDSMITTMGEKMAAQTLIVIGAGVSQKEGYYILNSRKEL
                     TNPPDPPGVGYCDSVLACK"
     gene            10001..10720
                     /locus_tag="HEK616_RS39140"
                     /old_locus_tag="HEK616_79620"
     CDS             10001..10720
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="HEK616_RS39140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79620"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_261958002.1"
                     /sec_met_domain="CDPS (E-value: 4.2e-58, bitscore: 192.5,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQASPATSNCQAIFGRREHVLLGVSPFNSRFGDAYIARLVAWAH
                     ASVQDFDVLLPGVEHASWILEAVGESRPLAKSRKEVGRRKRAVQEALEACAPERRLAVH
                     DFGDFADNPHYLGLRDEVERVFAADEGFRRACLDMSRQAVSSRLRTVRGPDACVDDGQA
                     AAAVRYVLDELPYVLDGATILGREEMLMVYYRPWPLWDRIERGEFPLKVSPRQGFLVLH
                     DCEEMRSGLTLRGTEPR"
     gene            complement(10838..12079)
                     /locus_tag="HEK616_RS39145"
                     /old_locus_tag="HEK616_79630"
     CDS             complement(10838..12079)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718837.1"
                     /locus_tag="HEK616_RS39145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79630"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_261958003.1"
                     /transl_table=11
                     /translation="MTGKGNSGFSEAGLRRLRDVLARHVETGKIPGLVALVSRGEETHV
                     EAIGTMRPDGGAPMRRDTIFRMASTTKPVAVAAAMVLLDECRLRLDDPIDRWLPELADR
                     RVLKRADGPLDDTVPARRPITVRDLLTSTFGLGLDMTAKDSPMMGALFEQGVYGQEDGW
                     LLPAPEPDEWMRRLGALPLMHQPGERWLYNVSDDVLGVLVARVTGQSFEDFLRARIFDP
                     LGMEDTGFHVPADKIDRLPPLCAPDPQTGEFIVADEAEGGHHSRPPAFQSGGGGLDSTV
                     DDYHAYFRMLLHHGMHGNQRILSRPAVELMTTNRLTPEQLAAREALARNLVHLSLGLGQ
                     HGGWGFGMAVRTYRGDYAPVGQFGWDGGAGTTTYADPDNQLIGILLTQTGMSTPDSARA
                     IHDFWTTLYQAIDD"
     gene            complement(12501..12890)
                     /locus_tag="HEK616_RS39150"
                     /old_locus_tag="HEK616_79650"
     CDS             complement(12501..12890)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007073481.1"
                     /locus_tag="HEK616_RS39150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79650"
                     /product="DUF1048 domain-containing protein"
                     /protein_id="WP_261958004.1"
                     /transl_table=11
                     /translation="MSDGEKSGFLSKVIGPKKRWRAYKARVKELPENYRTVVEAIEQYL
                     MHFVPTDSDSSASMFEDLADLFEQATANGTPIREIVGEDPVEFVEAFVQNYSEGGYVPP
                     RARKRLIEAIGRAAGEDTGKADKAV"
     gene            complement(12893..13222)
                     /locus_tag="HEK616_RS39155"
                     /old_locus_tag="HEK616_79660"
     CDS             complement(12893..13222)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542553.1"
                     /locus_tag="HEK616_RS39155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79660"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_261958005.1"
                     /transl_table=11
                     /translation="MTKLMTEMLKGTLEGIILASLSGRPAYGYEITARLREQGFSDIAE
                     GTIYALLIRMEKRGLVDVAKVPSEKGPPRKVHSLNAQGREYLEEFWRTWSFLTERLEQL
                     HEGGK"
     gene            complement(13474..13839)
                     /locus_tag="HEK616_RS39160"
                     /old_locus_tag="HEK616_79670"
     CDS             complement(13474..13839)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126416.1"
                     /locus_tag="HEK616_RS39160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79670"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_261958432.1"
                     /transl_table=11
                     /translation="MTDIQQAGRPNRLNVERQVVDGIHVVTVRGEIDHDVKDALSKALV
                     FEDGTVPPRIVVDLSGVPFMDSSGINVFVTLFQQVSDADGWLRIAGAQEPVLRILQLVG
                     IDSLIPCHPTAEQALSA"
     misc_feature    complement(13828..13843)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            14065..14493
                     /locus_tag="HEK616_RS39165"
                     /old_locus_tag="HEK616_79680"
     CDS             14065..14493
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676952.1"
                     /locus_tag="HEK616_RS39165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79680"
                     /product="ATP-binding protein"
                     /protein_id="WP_261958006.1"
                     /transl_table=11
                     /translation="MRAGYALEGDDGCIADARHYALDFLDQAHANHQLAVSARARDLLQ
                     LVVSELVTNARKYAPGPVLMELRVNAVAVDVVVWDSDPTVPAARATDPGRIGQHGLEIV
                     KAVTEALFIEQEPVGKRITARIALTDTDKQTPHRPRPT"
     gene            14685..15173
                     /locus_tag="HEK616_RS39170"
                     /old_locus_tag="HEK616_79690"
     CDS             14685..15173
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891806.1"
                     /locus_tag="HEK616_RS39170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79690"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_261958007.1"
                     /transl_table=11
                     /translation="MTNTSISRMPNPAEFVPEVNDISAALFRATGNRSVPRTTMSLVHL
                     RAGQIVRNTYLTVLNTGFLRKAGESEERITAVSSWQDAPYFTDAERAALALVEATLQPA
                     PHGQERVSDELYTEVAKHYDEKALATLTIAIGQINFFIALAVIGKPQPVTSLADEQWD"
     gene            15403..15573
                     /locus_tag="HEK616_RS39175"
                     /old_locus_tag="HEK616_79700"
     CDS             15403..15573
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673915.1"
                     /locus_tag="HEK616_RS39175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79700"
                     /product="hydrophobic protein"
                     /protein_id="WP_261958008.1"
                     /transl_table=11
                     /translation="MVPLLLVLLLALVLFGAGFAVKLLWWVAIAVLVLWLLGFVMRSTT
                     AGGGRSRWYRW"
     gene            15732..15863
                     /locus_tag="HEK616_RS39180"
     CDS             15732..15863
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS39180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_261958009.1"
                     /transl_table=11
                     /translation="MLEEFERAEAEESDPADSTHHVQKGDACTVNEEAQEETAKRKN"
     gene            complement(15895..16605)
                     /locus_tag="HEK616_RS39185"
                     /old_locus_tag="HEK616_79710"
     CDS             complement(15895..16605)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS39185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_79710"
                     /product="hypothetical protein"
                     /protein_id="WP_261958010.1"
                     /transl_table=11
                     /translation="MADPEYPRRPVLTALSVPVAALLLFAGGALGSFSWMLVPSIVLCL
                     VGGIWLLVAVMALSPSVILRAVTMVLMFVPMIGAPLSAMKASQALVLQARGVARPAVIT
                     RIAVHHGKTTTYGCTVRYDGSAKAAADAISCGRYDRVGDPVQVVRDPEGLVDPEFDGQV
                     RAGRAAAVLAVASEIALIALSVSAVGVGGVIHIVGRRRKPAGSAMRARSTRVDGPSSSR
                     EGKHPYSVVSPPQE"
     gene            complement(16721..17500)
                     /locus_tag="HEK616_RS39190"
                     /old_locus_tag="HEK616_79720"
     CDS             complement(16721..17500)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS39190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_79720"
                     /product="hypothetical protein"
                     /protein_id="WP_261958011.1"
                     /transl_table=11
                     /translation="MMTDLEQGEPAADNRALVPAGRHRRDGQVLPPRRRIRTRKARNAR
                     KAGRTTSPRRVALLIPAAALLVLAGGALASFRWMLVPSLVLGAAGGIWLIVMVPGLVPD
                     GALSRLMMALLAVPAVATAVLAANASQGFVLEMRGEVRSGVVARVIEHHGKTTSYECVI
                     RYHGVTKAPGRLDCGNSDHVDEQVRVAWDPSGWVEPDFAEANGTYRFFAILAMGSEIAL
                     VFLGEFTVFLGVVLRAARGDVARATGADGRPGVASAG"
     gene            complement(17533..18042)
                     /locus_tag="HEK616_RS39195"
                     /old_locus_tag="HEK616_79730"
     CDS             complement(17533..18042)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017793.5"
                     /locus_tag="HEK616_RS39195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79730"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_261958012.1"
                     /transl_table=11
                     /translation="MAGPQQEQQPQIESFDLFNPGGDPSVLRACAEAWRHMAHDLKGTI
                     ETQDQEVTRLGDDWTGAAAAAFHAHWKHTRGQMEKVLPQSETVAHQRQAPQGWACLSPR
                     LSGDHDRRPHLRRVQRCQHGNGRSIARVRGAHVPWRAVSPGPFPCRRCSWHQGEVKNTD
                     SVLARS"
     misc_feature    18037..18047
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(18044..18280)
                     /locus_tag="HEK616_RS39200"
                     /old_locus_tag="HEK616_79740"
     CDS             complement(18044..18280)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS39200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_79740"
                     /product="ESX-1 secretion-associated protein"
                     /protein_id="WP_261958013.1"
                     /transl_table=11
                     /translation="MDDRITTFATRAENVDDAFGVMSESTEVLSQYVEMPRHTVTSLRQ
                     LSAGPRHYAAGLQHTATSYQASDSAQAQQFGGK"
     misc_feature    complement(18331..18344)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.72"
                     /tool="antismash"
     misc_feature    18331..18345
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.84"
                     /tool="antismash"
     gene            18715..19248
                     /locus_tag="HEK616_RS39205"
                     /old_locus_tag="HEK616_79750"
     CDS             18715..19248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010063532.1"
                     /locus_tag="HEK616_RS39205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79750"
                     /product="hypothetical protein"
                     /protein_id="WP_261958014.1"
                     /transl_table=11
                     /translation="MDLTPYVDNLRQELAVAADAGGDDARALAERLTTPLESAVRLTLL
                     NALSAAMGEVTRELAPGSVDVRLRGLDPEFVVTAPPVPEPFREAHEPVAEPTVATPPPP
                     SADADDGAMARINFRLPAHLKARVEGAAAVEGLSVNAWLVRAVSTALDGGERRASQPAR
                     GKDAGGRGFTGWVR"
     gene            19359..20249
                     /locus_tag="HEK616_RS39210"
                     /old_locus_tag="HEK616_79760"
     CDS             19359..20249
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125606.1"
                     /locus_tag="HEK616_RS39210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_79760"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_261958015.1"
                     /transl_table=11
                     /translation="MPAYETPEPISATLELEVGTAHITAGKRTDTVVEVLPRDGSDDND
                     VRAVQQTQVTCSGGRLAIKTPKKWTLFGKPGAIEVSVELPTGSDVRGTSGMGSFSCEGS
                     FGDVTLKTALGDLQVDEVAGASLKTDHGDIRLVRSTGGVEVIGSGRIEVGTVTGAATVK
                     NSNGATKVAEVTGDLQTSSANGDISIGIAHSSVGAKCANGRIEIEIAHAGVEAMSSNGA
                     IRVGDVTRGRIDLRTSVGDLEVGIHEGTAAWLDLHPKYGTVRNALDSAAGPADSDETVE
                     VHARTLTGDITIRRA"
ORIGIN
        1 tgtgaaggca caggtcgatg cctgcggtca cgcccgcgga cgtcagcagg ggatcgtcgt
       61 cgatgtagag gacatcgcgg tccacccgga tgtggggata gagcctttcg agtgcgtcgg
      121 cgctggccca gtgcgtggtc accgtacggc cgttgagcag cccggccgcg gcgagtgcga
      181 aggcgccggt gcagatggag gcgatgcggg cacctcggcg gaaggcacgt ttcagggccg
      241 cggtgacttc gggcgccggt ggctgttggt agtcccagta gccgggcacg atgatcgtgt
      301 cggctcgggc cagtgccggt agtccggccg tgccaccaag tgtgaacccg gtgctggtcg
      361 tgatgctgcc acgggctccg ccgcacaccg tgagctcgta cggagtgtgg ggccgcgcat
      421 tgaagatctg cgtcgggatg cccaggtcga tggggaggac gcggggcagc gcaaggaccg
      481 cgacgcgatg aggagccatg gcttcgatgc tacgaccgcg ggtttcctgg ccggcccgag
      541 cctttgtcgg ccagcgagtg actgcccgca cgcgcgtgtc ccgaaagttg cggacagtgg
      601 catacgagct tgtggttgat cgagacaggc tggtcaacga tcgagtcatg agcagcacgg
      661 ccccaccgcc gggctcacgc cgacagcggc cgcaacagag cggcaccgca ccggcccagg
      721 caaggacacc tgactgtcgt gacccccaac acccccaccc cgatcggccg gtacttccac
      781 gtgaacgacg ggcggatcta cggccacgtc cgcgagggag aaggcccggc cctgatcttc
      841 ctccactact ggggcggctc ccaccgcacg tggcggccgg tcatcgagca cctcagcccc
      901 acgcagggct tcgtctccca cgaccaccgc ggctggggtg agtccaccga ggtgcctggc
      961 ccttacggca tcgagcaact cgccgacgac accgagcggg tcatcgacga gctcggctac
     1021 ggcgagtacg tcgtggtggg ccattcgatg ggagggaagg tggcccaggt gctcgcctcc
     1081 cgtcgcccca ccggtctggc gggcgtggtg ctcgtcgcac cggctccgcc ggctccggtc
     1141 ggtgtgacgc ctgagttcca ggaggcgctg gcgcacgcgt acgacaccga cgagaccatc
     1201 ggccgcagca tcgatctggt cctgacccac cgcgagctgt ccgcccaggc acgccggcag
     1261 attcacgagg acagcgcccg ggcgggcgaa gcggcgcgca tggcgtggcc acggcaggcg
     1321 ctggtcgagg acttcacgga ccgggtcggt gcgatcgacg tgccggtact ggtgctggcc
     1381 ggcagcgacg acaaggtgga cccgccgcac atcctgcgcg agcacctgct tcctgcgatc
     1441 cccaccgcca ccctcaccga gctcagcggc accggtcacc tgtcgccgct ggaggtgcct
     1501 gaccaggtcg ccgctcatat cggcaggttc gtcgcccgcc tgtcgacagt cgtcgaacgt
     1561 ggatgacggg aaaccggata ccgagcccgt actgcgcgcc ctggcagccc acgcgatccg
     1621 cggccgtatc aaccgctgac acccaccggg tgccccatcg cgggctgcgg gagcgggttc
     1681 gggggaacgg ccatgctcag caaggcgctg ttggtggtgg ccgtcgggcc gtcgacgttc
     1741 cccaagccgc tggtcgtcag cgtgcgaact tcgctatggc tgccggcgtg acgggggtga
     1801 agaagttgac gaggttgccg tcggggtcgc ggaacagcag cgaccggttg ccccagggca
     1861 tggtggtggg ctcgctgacg aagtcggtga tgaaggcggt caggttttgg tgaacgcgat
     1921 ccacgtcggc gacgaggaac tcggtgatca cgctgtggtt gtccgccggg cgggcagagc
     1981 ccggcgcgaa cagcgggacg gtgcgggtgc tggcgatcgc cagggtcgcg gtgggggtcc
     2041 tgagttcggc gaagtcctcg gtggcccacg tcgcctgcac atctgtggcc cgctcgtaga
     2101 actcgacgag gcgcgcgacg tcgctggtga tgatgcggat cgagacgaag tccatggtga
     2161 tctccttggc tgcgggagtg actgtgctgc gcagactagg aggaatagag gacagaatcg
     2221 gtccagtatt cgcgttaggc tgtgcacatg cctcgcccca ccggccgcgt cctgacactc
     2281 ctggagctgc tgcagtcggg cggcacacgg acgatgagcg aactggccga gcggctcggc
     2341 gtcgacgggc gcaccgtacg gcgatatgtg gaccacctga tcgacctcga cgtgcccgtg
     2401 gagtcggtgc gcggccggta cggcgggtac cgactggctc ccggctaccg cttgcctccg
     2461 ctcatgctca gcgacgacga ggcgctggtc gtgctgctcg gcctggtcgc cggtcgccga
     2521 acggggttga tgacggcggg gcacacggcg agcgagacgg catcggccaa gatccggcgg
     2581 gtgctgcccc agcacgtcgc ccgccggctc gacatgctcc tggaatccct cgccttcacg
     2641 gatcagcccg gtgagttcgc cgccccggac gcaggtgtcc tgctcaccct cgccgatgcg
     2701 gtgcgccacc gccgaccggt ctcgatgaga tacaccgacg gcggcggccg gcgcagcgaa
     2761 cgcacgctgc acgcctatgg gatcgtcgcc cattcgggcc ggtggtacgt cacgggccag
     2821 gacgcccagc gcggcgagga ccggaccttc cgcctcgacc gcatcgcaga cgcccggacc
     2881 ctgcccggct cattcgagcc gcccgtggat tccgggccgg cggagcgcgt gttgtccggg
     2941 ttcgccacgg ctgagtaccg gcatgaggtg accttgcgga tccacgggac cgttgagcag
     3001 atccgcgccc accttcctgc cggcgtcgcg agcctggagg agcacgagcc cgccgtggac
     3061 gacgaccggg tgaccgagcg ctggctgcgc gtccagctac gggcggagcg gctcgactgg
     3121 ttgcctccgg tactggccgc gctcgaccgg ccgttcgtca tcgagcgccc cgatgaactg
     3181 cgcgagctcg tgaccacgtt cgccgagcgc ctcgcctcct acgcccgcca agcctgacag
     3241 cgggtcatcg atgtcgtgag cggtgggtca cgctacgtgt ccgtctctcg tgcggggacg
     3301 ccgaagcctg tcgggtgcgg tctacgctgg agaggtcgtt cctccccacg ttcacctcgc
     3361 accgccgatg gcatccgaca cagagcggcg ccatgaccga agccacccct tcacccgagg
     3421 atctcgtcca ggccgttcga gcggtcggcg tcagggacga gcgtctcctc gaggccgtac
     3481 gcgcgacgcc ccgggcggcg ttcgtccccc acggtcacca ggcccatgcc tatgaggacg
     3541 cccccctgcc gatcgcccac ggtcaggtga ccacgcagcc ctcgctctcc gccctgatga
     3601 tcgagggcct tgaggtgagc ggggacgcac acattcttga ggtgggtacc ggcctcggct
     3661 tccagaccgc gctgctcgcc cggttggccg gcgatgtcgt gaccatcgag atgtggccgg
     3721 agctcgcgca tcaggcacgg cgcaacctcg accgtcaggg cattcgcaat gtcgagctgc
     3781 acatcggtga cggcagtggc ggcgtaccgg tccgtgctcc gtacgacgcg gtcatcgtct
     3841 ccgcggcgtt cccggaggtt cccgcgccgc tggtcgagca gctgcgtccg ggcggccgcc
     3901 tcgtgcagcc catcgggccg ggcggccggg agcaggtcat gtctttcgtg cgcaccgcga
     3961 cggggttgga gcgctgcagg gtcctcacac ccgcccactt cgtccggctg cgcggacggt
     4021 acggcttctc ctcttgaatt ccgcggacgg tgcggtcgcc cgccgccggc ttcgacggcc
     4081 tcgtgcgggc ggtggtctcc tgcagggtcc ggcccgcgtc cccggatagg gtcggggcgt
     4141 ggaccgcagc agccgacagc cggacgacgc gttcgccggg gaagcgcggg gcgagctgtc
     4201 gccccgggcg gcccgggcgc tgtggtgggg gtcggcaggt ctggtgctcg ccgtcctcgg
     4261 cacctcggtg ctcgtcgccg gcgcggggca cggctggcga ctgcccgtcg ccggggctct
     4321 ggtcctcgca caggcctgcg cgctgaggtg gctggggcgc gccccggtcg ccgtgctggc
     4381 cgcgaccgcc gcgacgggcc tcgcggtgtg ggcgctgctg cccgcggtga ccttgacggg
     4441 ggcgttgctc gcggcgcagg tggcgttgtg cgtactgtcg gccatcaggc cgcggcgggt
     4501 gtcggtgcgg gcgctcgcgg cgatgtgtct gccggcgccg ctggcgttcg gggcgggcgg
     4561 cccggcgggc ctgacggtct atctgctgac ggtggtcctg gcgtggaccg tgggacagtg
     4621 gcgcagggcg cagcaggcac ggacgagggc ggagatgcgc cgggccgtgg tggaggagcg
     4681 ggcgcggatc gcgcgcgagg tgcatgacgt cgtggcgcac acgctgtcgg tcatggtcat
     4741 ccaggcaagc gccgccgatg atgtgttcgg cgaacggccc gatcaggcac gtcaggcgct
     4801 gcgggccatc gagacgggtg cccgctctgc gctgggtgaa ctgcggttgc tgctgcgggc
     4861 gttcgggccc ggcgcggggg aggaggagtc cggggagcag cgggagccgg ggccctcgct
     4921 cgcgcgtctg gacgagctga tcgacaccgt gcgcgcgacc gggatgaccg tgtacgtaga
     4981 tcgtgcgggc accatcgagg ggctgccggc cgcggtggat ctggcggcgt accgcatcgt
     5041 ccaggaagcc ctgaccaaca cgctgcgcca cgcggccggc gccgacgagg tgagcgtgcg
     5101 cgtgacggcc gagggggagt gtgtgaaggt cacggtggtc gacaacgggc gtacgacgca
     5161 aggcagttgg gccgtagtgg gagcgggacg cggtctgatg gggatggagg agcgcgcacg
     5221 gctggtgggc ggcagtctgc acgccggtcg gctgcccggc ggcgggttcg aggtggcggc
     5281 ggagctgccg gtggagggcg cgtcatgaca ctgcgcgtgg tggtggccga cgaccaggtc
     5341 ctggtccgca ccggattccg catgatcatc gacgcccggg aggacctcga ggtggtcggt
     5401 gaggcgtccg acggccagga agcggtgcgg ctgacgcggg aactggcgcc cgacgtggtg
     5461 ctgatggacg tacgcatgcc cgtcgtggac ggcatcgagg cgacccggca gatcgtggag
     5521 tacggcagcc gggcgcgggt gctggtgctg accacctggg acgtggacgc gcatgtggtc
     5581 gcggccctgc gggccggggc gagcggcttc ctgctgaagg acatccgccc caccgaactc
     5641 gtcgacgcga tccgcctcac cgcgcgcggc gacgcgctgc tggcgccgac cgtgctgagc
     5701 cgcgtcctcg accggttcct gcgcaccacg cccgacccgg caccgccgcc ctccctgcag
     5761 gacctctccg gccgcgagcg ggaggtgctc accctgatcg ggcaggcgct gtcgaacgcg
     5821 gagatcgccg agcggctgcg cctgtcggag gccaccgtca agaaccacgt caccgcggtg
     5881 ctgcgcaaac tggggctgcg cgaccgcgtc caggccgtcg tggctgccta cgaccacggc
     5941 ctcgtgcagc cgcgccgccc ctgacggcag tccgcgccct ctctgacgcc aggccgcgtc
     6001 gcctctgacg gcaccgtctc ctcctcaagg aggaggccgg ggcacgatcc tcctgtgttc
     6061 ccagtgccgg tccgttcccg tggccgatcc gcggcggggg tagccgacca tagcgtcgag
     6121 gtgtgaacga cgacctggct tgcctcatgt atctgctcgc ccacgacgac gcggccgaag
     6181 gcccttacga ccgttcccgg acggagctgc tggtccgggc cgccgccctg atcgacctcg
     6241 cgttgcgcgg ccggctgggg gagacgggcg gcacggtcac cgtgtccggc acggaaccga
     6301 ccggcgaccc cgtcctggac ggcgtactgc gcgacgccac cgccgggcac ggctggaagc
     6361 acctcatgcg ccgccaccgc aagcggaccc tgacggaggt ggaggaccgg ctcgccgcgg
     6421 cgggactcct caccgtgcag acacccccca cccgcttcgg cacccggcgg ctgaccgtgg
     6481 cggaccgcgc cgtgcccgcc gcactccacg cccgcgtgtc cgcggtgctg cacggggacg
     6541 gccccgtgca ggagatcccc accgccgacg ccgcgctgct ggcactggcc gcggcgggcg
     6601 gcatccgctc ggtcgtgtca cggcaggacc agaacctctt tcgggcccgt atcgacgcct
     6661 gcacgggctc tctcgccgca ctcgcgcccg gcctggagaa agccgtacgc actctgccga
     6721 tgaccatgat cgccgcgcag ggcggcatgg gcggcagctg accggagggg agatgagcgg
     6781 ggagatgatg agcatgcacc gcgtcctgac caccctggga tgcgccctga ccgccgtagt
     6841 cgcgacggcc tggtccgcgg cactaccgtc ccagcccgtc cggcccgctg ccaccacggt
     6901 acggacgacc gagcccgccg ccacgacggt acgcacccac gacggcccgg tgcggggcgc
     6961 cacccacgac ggctaccgca ccttcgaggg catcccctac gcggcgcccc cggtcggcag
     7021 gctgcgctgg acgccgcccc gtcacccggc cccctggtcg ggggtacggg acgcgacccg
     7081 ccccgcgggc gcctgcccgc agccggccgg cgaggtgccc ggcggcagca ccgacgagga
     7141 ctgcctccac ctgaacgtca cgacgcccga cggcgcaggg cccgcacgtc cccggccggt
     7201 gatcgtgtgg ctgcacggcg gcggcttcac caccggagcg ggcagctcgt acgacgccca
     7261 ccgcctggcc acccgcggcg acgtcgtggt cgtcaccgtc aactaccgcc tcggggctct
     7321 cggtttcctc gcgcaccgcg ggctgcccgg ctccggcacc ttcggcctgg ccgaccagca
     7381 ggcggcgctg cgctgggtcc gcgccgagat cggcgccttc ggcggcgacg cgcacaacgt
     7441 gacgctggcc ggcgagtcgg cgggcggcta cagcgtctgc gcccagctcg cctcacccgc
     7501 cgccgcgggg ctcttcgacc gggcgatcat ccagagcggc ccgtgcaccg gccgctccga
     7561 ccggccgttc gccccgtcct ccgtcccctt gtccacggcg cgcgccgcgg gcgcggacct
     7621 cgcgacaaag gtcggctgcg gctccacccg cgaggtgatg gcctgcctgc ggcgcgtgca
     7681 cgtctcccgc ctgctggcac accagggcat cgaccaacag ccgtcctacg caaccccgtt
     7741 gctgcccggc gatcccgcag cggcgatcgc cgccggccgc ttcccgcgcg tccccgtgct
     7801 cctcggcaac aaccacgacg agggcaacgg ctgggccgcc gggatcgtcc aggccggcca
     7861 tcccgtcacc ccggacacct ggcccggcgt cgtggcctcc ttcttccccg ccccgggccg
     7921 gacgaaggcg atcgtccgcg agtacccggt gcaccgcacc gacggcggcc cggtgttcgg
     7981 cgcggtcatc ggcgacgcca acttcgcctg cccgacggcg cgcaccgaag acctgctcgc
     8041 ctcccaagtc cccgtctggc gctacgagtt cgccgatgag cacgccccgc cgctcacccc
     8101 gggcacaccg ccgttcccgc ccggcgcacc gcacgcgagc gagctgccct acctgttcga
     8161 tctgggcggc cgcccgcggc acctgaccgc ggcacagcac cggctggcca acaccatgat
     8221 cgactactgg gcccgcttcg cccgcaccgc cgaccccaac ggcccgtcgt cgccgcactg
     8281 gccccgccag acggtcctct ccctggcacc ggaccacatc gtccccaccc gaacgacgcg
     8341 agcccgccat cactgcgcgt tctggaacgc cctcgggtga ccacggagac gaccgccgtg
     8401 agggccgccg gatcggccga cggaccctca cggcacggac ccgcggcgtc gcccgggcac
     8461 cttcctcgtc gtggccctcg ggcggctcgt gccaggcaac cgcaacgacc gcaaggcatg
     8521 cccggggcct tgccgacggc ggcaccgaaa gacacggcct ggccacgatg ctggtgacgt
     8581 tggggtgcgg attgccggct gcggacggtc gacgcggcca gcagatgcgc ccgctcatag
     8641 ttggtgacac ggtggttgta cagcgtgaag ccaggcccta cgcacggagc cacgcgcccg
     8701 ccggaggcag cgcgacgccg tctccatcag cgcccgcccg ccgcggggtg gccgtgggca
     8761 tatcccgcga agaccgttcg accggcaggt agggacgctt cgatcctttg ggcggggcgg
     8821 gtccagggcg ttaccggccg ggcagccctg ctcggccgat caccatggag gtgctgctat
     8881 gactgccaag tacggagaga ggacgctctc ctcaaccccc gatcccctgt tgtgcggaag
     8941 cagtacggac gatgacactc tctggaaaat ggcgtggcag tgccaagaga ggcccaaagg
     9001 cagccgttgg ctcgtagcca aagggcaaca gggacacctc cttgttccca ccgatcgcat
     9061 cagaggaatc gagtgcccgg acctcgtgtc cggcgcctac tccgacaagg accacaacta
     9121 ctggcaggtg gcctgggaca gagcctacga ctggttctca aagccgcctt ggggaacctt
     9181 cggactgggg atcaacgcgg ccgggtcgcg ttcccaggac cagttgcaca tccacatgtc
     9241 tctggtcgtc cagggggtga cagccgacct caacaacgca tcgggcgcgg tcgccaagga
     9301 tttcgatcat tggccctact gtttggtcac ggtcaatggc tgggacaacc agaagaagca
     9361 gcgtgacccg cggagctacc gcgtggtcca caccaatacc ttggatttca acctcttcgc
     9421 tgccctccac gactccatga tcaccaccat gggggagaag atggccgctc agacgctgat
     9481 cgtcatcggg gcgggcgtga gccagaagga ggggtactac atcctgaaca gccggaaaga
     9541 gctcacgaat cctcctgatc ccccgggagt tggatactgc gacagtgtcc tcgcctgcaa
     9601 gtgagggtac gcgcggccga gtgtcgccag gcagggccat gggcctacgg ccccgggtcc
     9661 tgcccgcctg tctgcgccgg cgcaacgccg acgtcacgtc cgccaccgcg acgccctgac
     9721 cgacgaacgc aaggcggctt ttgacttccg accggtccgc ctgtcggcgt agttggcctc
     9781 ggtgccacat cgcgattttc gcccaatccg tataacctgt gcgaatcttc acccctttca
     9841 tcggtttgta gtaacgacag gcgagccttg gccgcaccgc aggaatgcgt ccggggtggc
     9901 gtcagacagg cgaacggagg cccgaggacg tggtgcgtcc cgcggccgtg atcgactcgt
     9961 ccgcccgttc ggccgcccta tcggaaggca tcgagacacc gtgctgcagg cgagccccgc
    10021 gacctccaac tgccaggcca tattcggacg gcgagagcat gtgctgctgg gcgtcagccc
    10081 gttcaacagc cgcttcggcg acgcctacat cgcccgcttg gtcgcctggg cgcacgcgtc
    10141 ggtacaggac ttcgatgtcc tgctgcctgg tgtcgagcat gcctcctgga ttctggaagc
    10201 ggtcggtgag tcccgccccc tggccaagtc gcgcaaggaa gtggggcgca ggaagcgtgc
    10261 ggtgcaggag gcactggagg cctgcgcgcc ggaacgccgg ttggctgtcc acgacttcgg
    10321 tgacttcgcc gacaacccgc actacctcgg gctccgcgac gaggtggagc gggtgttcgc
    10381 ggcagacgag ggcttccggc gcgcctgcct ggacatgagc cgtcaggccg tcagcagccg
    10441 gttgcgcacg gtccggggcc ccgatgcctg cgtcgacgac ggccaggcgg ccgcggcggt
    10501 gcgttacgtg ctggacgaac tgccctacgt cctggacggc gccaccatcc tcggccgtga
    10561 ggagatgctc atggtttatt atcggccctg gccgctgtgg gaccgcatcg agcgaggtga
    10621 attccccctc aaggtcagcc cccgccaggg attcctcgtc ctccacgact gtgaggaaat
    10681 gcgcagtggc ctgacgctgc gcggtaccga gccccgttga gggtggcgtc agcggctgtc
    10741 ttgagccggt catgcggatg atcgcagaac gtggagacgt cgaagaccgg cgcctggtcg
    10801 aggtcttctg ccggagcgac ctcgaccagg cagcaggtca gtcgtcgatt gcctggtaga
    10861 gggtggtcca gaagtcgtgg atggcccgtg ccgaatcggg ggtggacatc ccggtctggg
    10921 tgagcaggat gccgatgagc tggttgtccg ggtcggcgta ggtcgtggtg ccggctccgc
    10981 cgtcccagcc gaactggccg acgggcgcgt agtcgccgcg gtaggtgcgc accgccatcc
    11041 cgaagcccca gccgccgtgt tgccccaggc cgagtgacaa atggacgagg ttgcgggcca
    11101 aggcttctcg ggcggccagc tgctcgggcg tgaggcggtt ggtggtcatc agttcaacgg
    11161 cgggccggga caggatccgt tggttcccgt gcatcccgtg gtggagcagc atccggaagt
    11221 aggcgtgata gtcgtcgacg gtggagtcga gtccgccgcc gcctgactgg aacgccggag
    11281 gccggctgtg gtgtccccct tcggcctcgt ccgccacgat gaactctccg gtctgcggat
    11341 cgggagcgca gaggggaggc agccggtcga tcttgtcggc gggcacgtgg aaaccggtgt
    11401 cctccatgcc cagcggatca aagatgcgtg cacgcaggaa gtcctcgaac gactggccgg
    11461 tgaccctggc gacgagcacg ccgagcacgt cgtcgctgac gttgtacagc caccgttctc
    11521 cgggctggtg catcagcggg agtgcgccca ggcggcgcat ccactcatcc ggctccggtg
    11581 ccggcaacag ccacccatcc tcctggccgt aaaccccctg ctcgaagagc gcgcccatca
    11641 tcggggagtc cttcgcggtc atatccaggc cgagcccgaa cgtggacgtg agcaggtccc
    11701 gcacggtgat cggccgccgc gccggcacgg tgtcgtccaa cgggccgtcg gcccgcttga
    11761 gcacccgccg gtccgcgagc tcgggcagcc accgatctat tgggtcgtcc agccgcagcc
    11821 ggcactcatc cagcaggacc atcgccgccg ccaccgcgac cggcttggtc gtcgaggcca
    11881 tccggaagat ggtgtcccgg cgcatcggcg cgccaccgtc agggcgcatc gtcccgatcg
    11941 cttcgacgtg ggtctcctcg ccgcggctga ccagggcgac gagaccggga atcttcccgg
    12001 tctcgacatg ccgtgccagc acgtcgcgca gtctgcgcag ccctgcttcg gagaagccgc
    12061 tgttgccttt tcccgtcatg aatccccctg catgaagtgt gcgttgcaca caatgttggt
    12121 tctgtgaggc ccgtccccac gtggagtcca tgggccttgc acgggcgcgt gagacgtcgc
    12181 ccggttcgca accctgaggg cgcgatcgct gtgccgttcc aggcatccac caacggctct
    12241 gatgctgact gtcgccgtcc tgacgtcgtc tctgacgtgc ggcgcgaggt agccggccgg
    12301 tggctttgtg acgagccacg tcgtcgtctc gacatggttc cgggcgtcgc aggcccgtat
    12361 ggggaggcgc tgtaggtcga agcgctgctc cgtgccgcgt acgaagccac agccgggcat
    12421 gacccgtggc cgcgtagtgc cggcagtcga ggaaagtggt gcctggcgcg cccccccggg
    12481 cgtgatgtgc tgccttgttc tcagactgcc ttgtctgctt ttccggtgtc ctcgccggcg
    12541 gcgcgcccga tggcttcgat caggcgcttc cgcgcacgag gggggacgta gccaccctcc
    12601 gagtagttct ggacgaacgc ctcgacgaac tccaccgggt cctccccgac gatctcgcgg
    12661 atcggcgttc cgttcgccgt ggcctgctcg aagaggtcgg cgaggtcttc gaacatcgac
    12721 gcactgctgt cgctgtcggt cggtacgaag tgcatcaggt actgctcgat cgcttcgacc
    12781 accgtgcggt agttctcggg aagctccttg acgcgcgcct tgtacgccct ccagcgcttc
    12841 ttgggcccga tcaccttcga gaggaatccg ctcttttcgc catcggacat ggttacttgc
    12901 ccccttcgtg gagctgttcc agtcgttccg tgaggaagct ccacgtcctc cagaactctt
    12961 cgaggtactc ccgtccctga gcgttgaggg aatgcacctt gcgtggcggc cccttctcgg
    13021 aagggacctt cgccacgtcg acgagaccgc gcttctccat cctgatgagc agcgcgtaga
    13081 tggtcccttc ggcgatgtcg gagaaaccct gctcccgcag tcgtgccgtg atctcgtagc
    13141 cgtaggcggg ccgaccggac agcgacgcga ggatgatgcc ctccagtgtg cccttgagca
    13201 tctccgtcat cagcttggtc atggaacacc tccttcctga gctattcagt gctgctgact
    13261 actggtacac agtaacgctg actactggta cttagcaaga cggaatagtg agggggtgca
    13321 gtacgcgcag ccgtcatcgt cgtccggctc ggccgcggct gggctgcgca gcgggaggag
    13381 ggcgcgtgaa gggtgctggt ggctgtgcgg gcagcgtcga ggtgacagag acggtcgtac
    13441 ggcgggacgt gcaccgctgt tgccccaggg cggtcaggcg ctcagggctt gctcggcggt
    13501 ggggtggcag gggatgaggg agtcgatgcc gaccaactgc aggatgcgca gcacaggctc
    13561 ctgggcgccg gcgatgcgga gccagccgtc ggcgtcgctg acctgttgga agagggtgac
    13621 gaagacgttg atgccgctgg agtccatgaa gggcacaccg ctgaggtcca ccacgatccg
    13681 tggtggcacc gtgccgtcct cgaacaccag ggccttgctg agggcgtcct tgacgtcgtg
    13741 gtcgatctcg ccccgcacag tcaccacatg gatgccgtcg accacctggc gctcgacgtt
    13801 gagccggttc ggccggcccg cttgctggat atcggtcacc atttcctcga ctgtgcttag
    13861 gcttgcccgg gtcagaggtg cgcggacgat tctgccccac caccctgtcc ggacgcatca
    13921 gggctgaggg tgccgaacac ccctacggca tgcatggcgg ccggctgggt actgacgcac
    13981 gcgtgaactg gggagtgaag cgaggtgagg ccggtgggtt cccgagccga cggggacggc
    14041 tgtagggcgc tggatggacc tctgatgcgt gccggttacg ccctggaggg ggatgacggg
    14101 tgcatcgcgg atgcgcgcca ctacgccctc gactttctcg accaggccca cgcgaaccat
    14161 cagctggcgg tgtccgcacg ggcgagagat cttcttcagc tggtggtcag cgagctcgtc
    14221 accaacgccc gcaagtacgc cccaggcccg gttctgatgg aactgcgcgt caacgctgtc
    14281 gccgtcgacg tcgtcgtgtg ggacagcgac cccaccgtcc ccgcggcccg ggccaccgac
    14341 cccggcagga tcggccagca cggtctggag atcgtcaagg ccgtcacgga ggccctcttc
    14401 atcgagcagg agccggtcgg caagcgcatc accgcccgca tcgccctgac cgacacggac
    14461 aaacagacac cccaccgccc gcggccgacg tagccgccgg gccccggggt cggaaggtcg
    14521 gtccctgcgt cctgggcgtc gccggcgtca cgtccgcccg tacgcgtcgc caccaggtcc
    14581 gtagcgcggc gggaaaagtt tcttcggatt cctgtcacac cttcgttggc tggtccgtcg
    14641 gtgcagtgaa gccgccgatc aggccgatat gaaggagtgc agtcatgacg aacacctcga
    14701 tctcccggat gccgaacccg gccgagttcg tgcccgaggt gaacgacatc agcgccgcgt
    14761 tgttccgggc cacgggtaac cgttcggtgc cgcgtaccac gatgagcctg gtccacctgc
    14821 gggctggtca gatcgtccgc aacacctatc tgacggtgtt gaacaccggc ttcctgcgca
    14881 aggccggcga gtccgaggag cgcatcaccg ccgtttcctc ctggcaggac gccccctact
    14941 tcaccgacgc cgaacgtgcc gccctcgccc tggtggaggc caccctccag cccgcgccgc
    15001 acggccagga gcgcgtctcc gacgagctgt acaccgaggt cgccaagcac tacgacgaga
    15061 aggcactggc cactctcacc atcgccatcg gccagatcaa cttcttcatc gccctggccg
    15121 tcatcggcaa gccccaaccg gtcacctccc tcgcggacga gcagtgggac tgacctgaac
    15181 tgacctgaac tgacctgagg cgaccgtcag gccagcactg aacagcgcct gttgggtcta
    15241 cgcctcggct ttctcgcgag aactcatgga atgcgcttcc tcgtatcgcg tgtaccgctt
    15301 ttgtggcccc acatgcctcg gcctgccccg agcgatgaag gtgcagtcag aggaatgaag
    15361 ggagaagtgc ggggcacacg gaagctcagg aggtcgataa ctatggttcc cctgctgctt
    15421 gttctgcttc tggcgcttgt cctcttcggc gccgggtttg ccgtcaagct tctctggtgg
    15481 gtcgccatcg ccgtcctggt gttgtggctc ctcggtttcg tcatgcgctc caccactgcc
    15541 ggtggcggtc gcagccgctg gtaccgatgg tgatctcgac cgcataccaa acgcaccgct
    15601 agtagggccc ggccggcatg gcggccgggc cctacgccgc gccgaaggac atttccatgc
    15661 cgcgaaacag ggacagcatg ccgtgaaaca aggacagcga taagccctcc accaaatcgg
    15721 ccctcgacga agtgctcgaa gagttcgagc gtgccgaggc cgaggaatcc gatcctgctg
    15781 actcaactca ccacgtacaa aagggagatg cctgcacggt caacgaggag gcgcaggagg
    15841 agacggcgaa gaggaagaac tgagtgcgcg tgccggggag gcgtaggcgc tccgtcattc
    15901 ctgtggaggg ctgacgactg aatacgggtg ctttccttcc cgcgaggaag acgggccgtc
    15961 caccctcgtc gaacgggctc gcatggcgga gccggccggt ttacgccgac ggccgacgat
    16021 gtggatgacc ccgccgacgc cgacggccga gaccgagagg gcgatcaggg cgatctccga
    16081 cgcgacggcg agcacggcag cagcccggcc ggcacgcact tgcccgtcga attccggatc
    16141 gaccagcccc tcgggatctc gcaccacctg tacggggtcg ccgactcggt cgtaccgacc
    16201 gcaggagatg gcgtcggccg cagccttggc ggaaccgtcg tagcggaccg tgcagccgta
    16261 cgtggtcgtc tttccgtggt gcaccgcgat ccgcgtgatg acggccggac gcgctacgcc
    16321 ccgtgcctga aggaccagcg cctgcgacgc cttcatggca ctcagcggtg cgccgatcat
    16381 cggcacgaac atcagcacca tggtcaccgc ccgcaggatg acggacggag acagcgccat
    16441 caccgccacc agcagccaga tgccgccgac caggcacagc acgatcgagg gcaccagcat
    16501 ccagctgaac gaccccagcg ccccgcctgc gaacagcagt agggcagcca ccgggacgga
    16561 cagtgcggtc agcaccgggc ggcgtgggta ttccggatcg gccatccgct tcctcctcac
    16621 gcgccgtgtg cccgtcgtca tcacctcccc cgctccgtcg gtcatggccg gcgcacgatc
    16681 gttccgcgag gtggccggcc gggccccagg gtgggcgcgc tcatccggca ctggccactc
    16741 cggggcggcc gtccgcacca gtcgctcggg ccacgtcccc gcgggcggca cgcaggacga
    16801 cccccaggaa caccgtgaac tcgccgagga acaccagcgc gatctcactc cccatggcga
    16861 ggatcgcgaa gaaacggtac gtaccgttcg cctcggcgaa gtcgggctcg acccacccgc
    16921 tggggtccca cgccacccgt acctgctcat cgacatggtc ggaattgccg cagtcgagtc
    16981 tgcccggcgc cttggtgaca ccgtggtaac ggatgacgca ctcgtacgag gtggtcttcc
    17041 cgtggtgctc gatgacccgc gcgaccacgc ccgaccgcac ctcgccccgc atctccagga
    17101 caaaaccctg cgaggcgttc gcggccagca ccgcggtggc gaccgccggc acggccaaca
    17161 gcgccatcat cagccggctc agcgccccat cgggtaccag cccggggacc atcacgatca
    17221 gccagatgcc gccggccgcc cccagcacga gcgaaggcac cagcatccag cggaacgaag
    17281 ccagcgcccc gccggccagg acgagcagcg cggcggccgg aatcagcagc gcgacccgtc
    17341 tcggactggt cgtgcgccca gccttacgcg cgttacgcgc cttacgcgtc cggatgcggc
    17401 gccgcggggg cagcacctgc ccgtcgcgcc ggtgtcgccc cgccggcacc agcgcccggt
    17461 tgtcggccgc cggttccccc tgctccaggt ccgtcatcat gctccccccg accgccgagc
    17521 caaacatcaa cttcaggagc gcgccaagac gctgtcggtg ttcttgacct caccttgatg
    17581 ccaagaacac cgacggcagg ggaaagggcc cggactgacg gcacgccagg ggacgtgggc
    17641 ccctcgaaca cgagcgatcg atcgtccgtt gccgtgttgg caccgttgaa ctcgccgtag
    17701 atgaggccgt cgatcgtgat ctcctgaaag gcggggagag aggcaggccc acccttgcgg
    17761 tgcttgccgc tgatgagcca cggtttcgga ctgcggcaat accttctcca tctggcccct
    17821 ggtgtgtttc cagtgggcgt ggaaggccgc cgccgcggcg ccggtccagt cgtcgccgag
    17881 ccgggtgacc tcctggtcct gggtctcgat cgtgcccttc agatcatggg ccatgtgccg
    17941 ccaggcctcg gcacaggccc gtagcacgga cgggtccccg ccggggttga acaggtcgaa
    18001 gctctcgatc tgcggctgct gctcctgctg cggtccggcc atgtcacttc cccccgaact
    18061 gttgcgcctg cgcggaatcg gatgcctggt acgaggtggc ggtgtgctgc aggcccgcgg
    18121 cgtagtgccg cggcccggca ctcagttgtc gcagggaagt caccgtgtgg cggggcatct
    18181 ccacgtactg ggagaggacc tcggtggact ccgacatcac gccgaaggcg tcatccacgt
    18241 tctccgcgcg ggtggcgaag gtggtgatgc ggtcgtccaa gtggtcggaa gaggacgcga
    18301 agtccttggc taacgccgaa ccggctcggg atgtatcgaa aaattctcgt gcggcattgc
    18361 agcccccatg gtgaaaccgt acgtgatcac cggtgctgaa ggagttcggc ggcaccggcg
    18421 cgcgctaccg ccaccaccgg agcctggtga acgcaccggc ccggtgaacc gcgccgccgc
    18481 cccgatgttg cggaccgcgt cgggccaggc caggccaggc ccgacgcggt gtagtccgtc
    18541 ccgagctcaa gtggcgccac catggcgtca ccgcggtgcc gccgtgagcc atctcgccgt
    18601 gaagacggcg tcacggcacc tcaattcaag gaagaacgcc aggtcagagt ggtgtgcgcc
    18661 aaaagggagc caatctggct cgccatggcg ccatacgtgt gccatgatgg cgtcatggac
    18721 ctcacgccct acgtcgacaa cctccggcaa gagctggccg tcgccgcgga cgccggcggc
    18781 gacgacgccc gcgccctcgc cgagcggctc accacccccc tggagtcagc cgtccgcctg
    18841 acgctcctca acgccctgtc cgccgccatg ggtgaggtca cgcgcgagct ggcgccgggc
    18901 tcggtcgacg tgcggctgcg cgggctcgac ccggagttcg tggtgacggc gccgcccgtc
    18961 cccgagccgt tccgcgaggc gcacgagccg gtcgcggagc ccaccgtggc cacgccgccc
    19021 ccaccgtccg cggacgccga cgacggcgcc atggcgcgga tcaacttccg cctgcccgcc
    19081 cacctcaagg cccgcgtcga gggcgccgcc gccgtggagg gcctgtcggt caacgcctgg
    19141 ctggtgcggg ccgtgtccac cgccctcgac ggcggggagc gtcgtgcgag ccagccggcc
    19201 cgcggcaagg acgcgggcgg ccggggcttc accggctggg tccgctgagg cccccggccc
    19261 acaccacttt caccggcgga tcaccgatcc cgccgacgtc actcatcacc cgcctcacca
    19321 gcgggatcag ccacccgagc caagaggacg gaacagccat gcctgcttac gagacccccg
    19381 aacccatctc cgccaccctc gaactggagg taggcaccgc ccacatcacc gcgggcaagc
    19441 gcaccgacac ggtcgtcgag gtgctgccgc gcgacggctc cgacgacaac gacgtacgcg
    19501 ccgtgcagca gacccaggtc acctgctcgg gcggccgcct cgccatcaag actcccaaga
    19561 agtggacgct gttcggcaag ccgggcgcca tcgaggtgag cgtggaactg cccacgggat
    19621 cggacgtccg gggcacctcg ggcatgggca gcttctcctg cgaaggcagc ttcggggacg
    19681 tcacgctcaa gaccgcgctc ggcgacctcc aggtcgacga ggtggccgga gccagcctca
    19741 agaccgacca cggcgacatc cgactggtcc gctcgaccgg gggcgtcgag gtcatcggct
    19801 ccggccggat cgaggtcggc accgtcaccg gcgcggcgac cgtcaagaac agcaacggcg
    19861 cgaccaaggt cgccgaggtc accggcgacc tgcagaccag ctcggccaac ggcgacatct
    19921 ccatcggcat cgcgcacagc agcgtcggcg ccaagtgcgc caacggccgg atcgagatcg
    19981 aaatcgccca cgccggggtc gaggcgatgt cctccaacgg cgccatccgc gtcggagacg
    20041 tcacccgcgg ccgtatcgac ctgcgcacct ccgtcggcga cctcgaagta ggcatccacg
    20101 agggcaccgc ggcctggctc gacctgcacc ccaagtacgg cacggtacgc aatgcgctcg
    20161 actccgccgc cggccccgcg gactccgacg agaccgtcga ggtgcacgcc cggaccctga
    20221 ccggcgacat caccatccgc cgcgcctgac cgggcgcacc ccaactcccg cacctgaaag
    20281 gaaaagtggc atgactgcca cccggacatc cgcgccgatc gccgcgaacg cgacggcgcc
    20341 ggcgatcacc gccaccggat tacgcaagtc ctacggcgac aagcgcgtgc tcgacggcat
    20401 cgacctgaac atcgccgaag gcaccgtctt cgctctgctc ggccccaacg gcgccggcaa
    20461 gaccaccacg gtggagatcc tcaccacgct catcgaagcc gacgcgggcg aggcctgggt
    20521 cgcgggtcgc catctgaccc gggccgccga cgcggtgcgc tccacgatcg gcgtcaccgg
    20581 ccagttctcg gccgtcgaca acctgctgac cgccgaggag aacctgctcc tcatggcgga
    20641 tctgcaccac ctcgaccgac gtgaaggcaa gcgacgggcc aaggacctgc tgcgccgctt
    20701 cgacctgtcc gaggtggcgg
//
