LOCUS       NZ_AP026074            24837 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 plasmid SNP1.
ACCESSION   NZ_AP026074
VERSION     NZ_AP026074.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1073703)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 223459
            Orig. end                         :: 248296
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026074.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24837
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24837
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24837
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14837]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14837
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    89..104
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            complement(397..1515)
                     /locus_tag="HEK616_RS37635"
                     /old_locus_tag="HEK616_76570"
     CDS             complement(397..1515)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717233.1"
                     /locus_tag="HEK616_RS37635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76570"
                     /product="hypothetical protein"
                     /protein_id="WP_261957736.1"
                     /transl_table=11
                     /translation="MADQTARESSGAQRGWRFLLAVGFGLVLLLLSAGLFATVPVELAK
                     WDAYAAAPACPAGSRSDTCTTTVPATVKGTEDEPSGKSVRYWLRVTERGTDTVRRVRMA
                     GSEPVYDTVRAGDEVKLTYWRGEIRTVRFRAAAQETWESPDGNWRYPLGAGLFLLPFGL
                     MVWWLTWWHRHHSPSPTHRSLRQLTVGLVTGTVVSCAGSLGSMVGRDVREALLITAAAV
                     LPAAGLGALCAWGQQRRINRAAASVSSIVPVPPTDKQCVRAAVLGDVPYRVDGFDHLVL
                     GDGRPATTPDPDGRVARKTVPETLVVRHVRALRPDDPQAWKQRFKYDAAVIECRDGDHA
                     VLIALARRDAPLALGALRAMGQPSSPVTSPDL"
     gene            complement(1728..2012)
                     /locus_tag="HEK616_RS37640"
                     /old_locus_tag="HEK616_76580"
     CDS             complement(1728..2012)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153343.1"
                     /locus_tag="HEK616_RS37640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76580"
                     /product="hypothetical protein"
                     /protein_id="WP_261957737.1"
                     /transl_table=11
                     /translation="MNPSVARLWQEHVAADFPVRLRGVELAGIDMVLLDADIAGCVSAW
                     RNGDGSLDAERHRILRRCIADLNTILPLLTDEDDHRYYARLHRLAALLS"
     gene            complement(2009..2497)
                     /locus_tag="HEK616_RS37645"
                     /old_locus_tag="HEK616_76590"
     CDS             complement(2009..2497)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040274.4"
                     /locus_tag="HEK616_RS37645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76590"
                     /product="DUF5959 family protein"
                     /protein_id="WP_261957738.1"
                     /transl_table=11
                     /translation="MGEPEPVDLIHLADADANGDGNGNRCIVRVTGRDQPGVLTGHDTL
                     RAEVLVSTGFLDARLELYLFQRDLSAWEEELERLVPRGNAGLGGGRGLELGIQLNEDAS
                     VGVTINDPDRLSTFFWIRPQDDWIQDHRARLDRVRQAWPSEVVETAPMTYEWSPRRKK"
     misc_feature    2490..2507
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            2801..4009
                     /locus_tag="HEK616_RS37650"
                     /old_locus_tag="HEK616_76600"
     CDS             2801..4009
                     /NRPS_PKS="Domain: PKS_ER (201-327). E-value: 1.9e-12.
                     Score: 38.9. Matches aSDomain:
                     nrpspksdomains_HEK616_RS37650_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011927031.1"
                     /locus_tag="HEK616_RS37650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76600"
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /protein_id="WP_410011404.1"
                     /sec_met_domain="ADH_N (E-value: 8.1e-11, bitscore: 37.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.1e-12, bitscore:
                     42.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGTGEVVVDVVAAGVLPYAAEVFRGERRYLLTLPVIPGSGAVGR
                     VRAVGPDSTRLRVGDWVLCDPTIRARDDALTPDITLQGLSARGEGGLRLQQHFGQGSFA
                     EQLLVPTENVFPLGATGATRATGATGATGATGATGATGATGATGATGATGATGATGATG
                     ATGASDATGTTGASDATDAADAGRWCALPVLLVPYGGLLAAGLQAGQTVLISGATGNFG
                     SAAVAVALAMGAGCVVAPGRNEKMLGELERRFGSRIRTVRLSGDEAADRERMRAAAPAP
                     IDVVLDLLPPSAAMTAVRAAVMTVREHGTVVLMGGVGMLGGDDLALPYPWLMRNNITVR
                     GQWLCPRHANPQLIRLANSGQLDLRQFDVTAFDLADANTALRHAAAEGGRFSLTVIRPV
                     REG"
     aSDomain        3404..3781
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS37650_PKS_ER.1"
                     /evalue="1.90E-12"
                     /label="HEK616_RS37650_PKS_ER.1"
                     /locus_tag="HEK616_RS37650"
                     /protein_end="327"
                     /protein_start="201"
                     /score="38.9"
                     /tool="antismash"
                     /translation="LAAGLQAGQTVLISGATGNFGSAAVAVALAMGAGCVVAPGRNEKM
                     LGELERRFGSRIRTVRLSGDEAADRERMRAAAPAPIDVVLDLLPPSAAMTAVRAAVMTV
                     REHGTVVLMGGVGMLGGDDLAL"
     CDS_motif       3425..3487
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEK616_RS37650_0001"
                     /evalue="5.10E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="HEK616_RS37650"
                     /protein_end="229"
                     /protein_start="208"
                     /score="19.0"
                     /tool="antismash"
                     /translation="GQTVLISGATGNFGSAAVAVA"
     gene            complement(4150..5019)
                     /locus_tag="HEK616_RS37655"
                     /old_locus_tag="HEK616_76610"
     CDS             complement(4150..5019)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676882.1"
                     /locus_tag="HEK616_RS37655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76610"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_261957739.1"
                     /transl_table=11
                     /translation="MENWYVDDRCTNCDVARQFAPDLITEADGKSQILRQPRDEAENRR
                     LHAAVFACPTRSIRPASGLADRTLDPFPMALDDGVLVCGHNSRDTAGANSYLLLRPSGS
                     VMMIDTPRWSRELAARYTALGPVTDVLLTHRDHVAHGRRYADHFGARLWIHEGDLDAAP
                     DADQVIRGLEPVDIGEGVTAHPLPGHTRGSVLYLADDRYCFSGDSFYWSRTTGDLEVAE
                     NVTWYSIEELANSLARTTPQLRFEWVLPGHGNRHHLPADEMSRRLESLTERTRLLRPQP
                     IDFTAVRW"
     gene            5798..6682
                     /locus_tag="HEK616_RS37660"
                     /old_locus_tag="HEK616_76630"
     CDS             5798..6682
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543401.1"
                     /locus_tag="HEK616_RS37660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76630"
                     /product="hypothetical protein"
                     /protein_id="WP_261957740.1"
                     /transl_table=11
                     /translation="MASAGRTEAALPVAGATGRAAEKFSYSLASEAPVGLWTSSGVTLR
                     TPVSKGTVRLDVTTRGFSAASLMIQRYVPKTHRWVDLDQRPVGSEHPEKGTFTFPVSVA
                     ASAGHPATVALRVQDIDRPGRLTVAASVRDGHGHTYRAPARSAVVDRPTTTITGWSRGT
                     ALVPGGAAKDFTLAVKNTTKRAYPALNAGYFAYGQGSGRAVEPKDLVLQQYVPGHGWQR
                     VSLLPGGCDPGMAAQLIPTAKTPLAPGATAVYRLRLAVADSAPVTDVDAGVSVGTGDTS
                     FFYRTLPFEIRAK"
     gene            complement(6743..7552)
                     /locus_tag="HEK616_RS37665"
                     /old_locus_tag="HEK616_76640"
     CDS             complement(6743..7552)
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-241). E-value:
                     1.8e-31. Score: 101.6. Matches aSDomain:
                     nrpspksdomains_HEK616_RS37665_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359156.1"
                     /locus_tag="HEK616_RS37665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76640"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_261957741.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-23, bitscore: 78.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.1e-26, bitscore:
                     88.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYATANGTRLFYTDSGTGIPVLFLHGWGTSGRVWGAQVADLAAD
                     HRVVTVDWRGCGRSDHPATGNTTATNAADILALMDRLALDRPLLVGSSLGATFALEAAL
                     GAPERVGGVVSISGPGYWPSQGMAAPLRALRAALAADRPAALADWVPQWFAPTADPALA
                     EQTRRQILRSGVFIDELFAESNLHDPRADIGRLTVPALFIHGRLDTEVPLDVSRTLAAL
                     ALYGEFHAIEQAGHMPHQEQPAAVNALIRTALARQAAGTIPTATRSS"
     aSDomain        complement(6830..7492)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS37665_Abhydrolase_1.1"
                     /evalue="1.80E-31"
                     /label="HEK616_RS37665_Abhydrolase_1.1"
                     /locus_tag="HEK616_RS37665"
                     /protein_end="241"
                     /protein_start="20"
                     /score="101.6"
                     /tool="antismash"
                     /translation="PVLFLHGWGTSGRVWGAQVADLAADHRVVTVDWRGCGRSDHPATG
                     NTTATNAADILALMDRLALDRPLLVGSSLGATFALEAALGAPERVGGVVSISGPGYWPS
                     QGMAAPLRALRAALAADRPAALADWVPQWFAPTADPALAEQTRRQILRSGVFIDELFAE
                     SNLHDPRADIGRLTVPALFIHGRLDTEVPLDVSRTLAALALYGEFHAIEQAGHMPHQE"
     misc_feature    complement(7706..7720)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    complement(7801..7818)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.5"
                     /tool="antismash"
     gene            7869..8099
                     /locus_tag="HEK616_RS37670"
     CDS             7869..8099
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS37670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_261957742.1"
                     /transl_table=11
                     /translation="MTEDVVDIDRQQLMVEALQEFAARSDEQLDWTLGLVRHRLGAARR
                     LGVPVPEDLASRVARLCEKRNLPLYEPEQRD"
     gene            8472..10004
                     /gene="crtI"
                     /locus_tag="HEK616_RS37675"
                     /old_locus_tag="HEK616_76660"
     CDS             8472..10004
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091573.1"
                     /locus_tag="HEK616_RS37675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76660"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_261957743.1"
                     /sec_met_domain="DAO (E-value: 5.5e-19, bitscore: 64.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTLPGPTDHVVVVGAGLSGLSAALHLLGAGRRVTVVERAELPGG
                     RAGRVDRGGYRIDTGPTVLTMPDLIEEAFAAVGERLSDRVVLDQLHPAYRARFADGSEL
                     DVHTDPRAMEAEVERFAGPRAAHGYRRLRRWLEQVYRAQHRRFIDSNFDSPLQLLHPDL
                     ARLAALGGFGRLDDRIGRFVPDPRLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAGV
                     YFPRGGMHALPRAMADAAAAAGAAFRYGTPVTRLERTGGRITAVVTEHERIACDAVVLT
                     PDLPVTYRLLGRRPRRPVRLRHAPSAVVLHAGGARTWPGTAHHTLSFGAAWERTFDELT
                     RRGRLMSDPSLLVTRPTASDPALAPPGRHLHYVLAPCPNTETGPGAEAWPALAPRYRDS
                     LLSLLEQRGFRGIADAEDLGTVTPADWAAQGLAAGTPFSAAHTFAQTGPFRPRNLVRGT
                     ENAVLAGCGTTPGVGVPTVLISGKLAAARVTGLRPPRSRAGAPRPGDRTVPA"
     gene            10001..10990
                     /locus_tag="HEK616_RS37680"
                     /old_locus_tag="HEK616_76670"
     CDS             10001..10990
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982462.1"
                     /locus_tag="HEK616_RS37680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76670"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_261957744.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.9e-119,
                     bitscore: 393.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.4e-65,
                     bitscore: 216.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERELTAAGITDPRLRADYAHCRRLNARHGRTYFLATRLLPADR
                     RPAVHALYGFARHADDLVDHPATGSSTADRARALSALHRNLQNGLRGDPSPEPVVRAVA
                     HTVAAYDIDHAHFADFLTAMRMDLVVTDYPTYADLRSYMHGSAAVIGLQILPVLGTVVP
                     RHEAAPHAAALGVAFQLTNFVRDVGEDLDRGRVYLPADLLAAHGVDRALLRWSRDTGRP
                     DTRISQALAAAAELTRGVYREAAPGLAMLDPVARPCMRTAFVLYGAILDAVREDGYAVL
                     HRRAVVSRRRRAATALGGLARSVAARLTARPPAAPRERTPQPAQKESA"
     gene            10987..12000
                     /locus_tag="HEK616_RS37685"
                     /old_locus_tag="HEK616_76680"
     CDS             10987..12000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607877.1"
                     /locus_tag="HEK616_RS37685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76680"
                     /product="Rieske (2Fe-2S) protein"
                     /protein_id="WP_261957745.1"
                     /transl_table=11
                     /translation="MSPDGRHRPRVPLRLRRGPERWERQRSTWREARPAVIDGALKRAL
                     ARRSGNWFVLGAARDVEPRKPFGRTVAGVEVVAWRDAAGRLVAGPGACPHLGAPLAEGA
                     VHCGTLRCRWHGLALDGAAFAGWEPFPAHDDGVLAWIRLDAAGGERPLPRPVLPPRPGP
                     AGTLVAVHTAVGACEPEDVVANRLDPWHGAWFHPYAFVDLRVVGAPTEAGTEGPDEFLV
                     EVSFKVAGRAVVPVTARFTAPEPRTVVMHLVDGEGKGSVVETHATPLAPDDRGRPRTAV
                     VEAVLATSDRPGFALARAAAPLVRPLMRAAAGRLWRDDLAYAERRWQLRRSGRYPG"
     gene            complement(12082..13620)
                     /locus_tag="HEK616_RS37690"
                     /old_locus_tag="HEK616_76690"
     CDS             complement(12082..13620)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888661.1"
                     /locus_tag="HEK616_RS37690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76690"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_261957746.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 8.1e-08, bitscore:
                     27.7, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 3e-14, bitscore: 49.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSARRGRDRRARVLPGPPGNDRAAADGRPAVAVIGGGIAGLAAAT
                     ALAERGVRVTLYEREGVLGGRLAGWPVRLADGSAATMSRGFHAFFPQYYNLRGLLRRID
                     PGLRVLRRLPDYPLQHRSGTRDSFARVPRTPPWSALGFMALSPTFAWRDLARMRPAAAL
                     PLLDVRVPQIYQRLDDTSAWDLLDRIGFPEAARHLAFEVFSRSFFADPRQLSAAEMALM
                     FHIYFLGSSEGLLFDVPAEPYPEALWAPLARYLEGHGVRLRTGTPVDRVEPQAGGGVHV
                     ATNSGSHPYDAVVLAVDTAGLRRIVAASDGLGDPAWRARIGRLRTAPPFLVSRLWLARP
                     VSPDRAGFLGTSGFGSLDNISVLERWEGEAARWSGRTGGSVLELHAYAVRPDADRAHEQ
                     RRLVEQLHAVYPETRGARIVDQRHEWRADCPLFAVGGHADRPTVHTPDPRVVVAGDLVR
                     TALPVALMERAATTGFLAANALLARWGVRGHPLWTVPDKGRVAPLRWAAGRTGH"
     gene            complement(13647..14837)
                     /locus_tag="HEK616_RS37695"
                     /old_locus_tag="HEK616_76700"
     CDS             complement(13647..14837)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607875.1"
                     /locus_tag="HEK616_RS37695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76700"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_261957747.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 7.2e-96, bitscore:
                     317.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDADVVIVGAGAAGLSLAYRLCAPGAGARRPTVVLVEAPRGPRT
                     PPERTWCFWEPPGGEFDPALTAVWDALRVYGPDGTETVGWPAPLRYKMLRSGDFAAVVE
                     ARLAGDPAVRRVEATVAAVRDTADGAEVRGCDGAGRPVALRSRWVFDSRPGSLLPPART
                     TLRQHFRGWFVRTRRAVFDPAVADWMDFRVPQPAHGLAFGYVLPLDPHTALVEYTRFSR
                     RPLDVAGYERALRHYTDEVRKLGPFEITGTEQGVIPMTDGRFPHRAGRSVFRIGTAGGA
                     TRPSTGYTFAAVQRQTAGLAAALRQPGSPPPPPVHSRWARALDAVLLRGLDSGRVDGAA
                     VFTDLFGAVPTERLLRFLDGRSRLWEDLTIGLRTPVLPMLRTVAELPLLPRKTAPW"
     gene            complement(15015..16325)
                     /locus_tag="HEK616_RS37700"
                     /old_locus_tag="HEK616_76710"
     CDS             complement(15015..16325)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127796.1"
                     /locus_tag="HEK616_RS37700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76710"
                     /product="purine-cytosine permease family protein"
                     /protein_id="WP_261958414.1"
                     /transl_table=11
                     /translation="MADQAGPDVQFLADSAEGDALQPLGQGDGCRRGDDLRAPGGRVLF
                     WLLTGLLAVSGPAAGAPSEVITRAMYGIRGNRVNNAVTGWLVSVCYFALNLAAAATAAF
                     SLVERAGIPTTTGVKIAVVIAVAALTLTISVYGHALIMKLYLPITLALTAVFAVLACYV
                     LRHTDFSYSPTEPLAGTSRWAALLGGVTLIASGPLSYTTSADFSRYLPRTASPKAIVGW
                     TAFGGFLPSVVVCSLGAFAATAVDMTDPQHALEKILPGWFVPLFLLALVLGTVALNALT
                     AYSAGLALQAVGLRIRRSVSVLADGTVSVSLTLYALLVSNFLDTVSNVLQLTVGLLGPT
                     MAVYATDILLRRNRYDGPALTDETPGSPFWYTGGVNAAGATALIGGTACAALCMNTLYT
                     GPVARALHGINLALPVGIAVASALYCFGVKLVPPRGR"
     gene            16221..16808
                     /locus_tag="HEK616_RS37705"
                     /old_locus_tag="HEK616_76720"
     CDS             16221..16808
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308107.1"
                     /locus_tag="HEK616_RS37705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76720"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_261958415.1"
                     /transl_table=11
                     /translation="MVAAAAAVALTEGLECVTLRRIGEELDVRPGLISHYFPSAEDLVA
                     EAFGHAATGELDSLVPVERPEGSPLRHLARFFAQTTGERYDAISRLWLNARHLSRYRPV
                     LRDRVAVQEAGWRGRLSGLLQEGVEQGEFHTDDPQLTAIQILVVLDGLGAHANTETGSH
                     PEAVTRMAITTAERELGLADGALTRPTDASGA"
     misc_feature    16355..16369
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            16895..18517
                     /locus_tag="HEK616_RS37710"
                     /old_locus_tag="HEK616_76730"
     CDS             16895..18517
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072245.1"
                     /locus_tag="HEK616_RS37710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76730"
                     /product="amidohydrolase"
                     /protein_id="WP_261957748.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.3e-16, bitscore:
                     55.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTPLVLLSARLLDPVSGAFLPDTALAVSDGRIASLGDDRDIRAL
                     AGPSTTVIDLKGAVVTPGLVDGHLHPVSGAELTHGLDLSGCTDLESVREALAREVRRLA
                     PGAWLHGWGLDPNVFGDRPVESAALAPVLDGVPAFLLLFDAHSALASERALELAGVDGP
                     RRFDQAAEVVCDDAGRPTGLLLEDAACELVERVAPQPTREERRARLATTLRAMAAAGLT
                     GGHAMDANGDSLAFYAELDAAGELPLRLRVAPWCQPGTDAAGLRALIDGQGAGGTLWRT
                     AGVKLFMDGTIDNGTAWLERPDCHGESTHAFWPDPDAYTRVIGELHAAGVPTATHAIGD
                     AAVRHALDAVEKAQADGRRGVRHRIEHIETVPDDTLRRFAQLGVIASMQPTHCCDFTRA
                     DRTDNWSRRLGEERASRAWRCRDLTDAGATVVLGSDWPIAPYPPLGVLAGARHRRPSRD
                     LTRPPHGPDQALTPLEALQGMTVNAARAAGEEHEAGRLAVGHRADLTVLADDPLTTPAT
                     DLPDLPVLLTVLDGRPTHRDTSL"
     gene            complement(18543..21695)
                     /locus_tag="HEK616_RS37715"
                     /old_locus_tag="HEK616_76740"
     CDS             complement(18543..21695)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018349407.1"
                     /locus_tag="HEK616_RS37715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76740"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_261957749.1"
                     /transl_table=11
                     /translation="MQIGMLGPLEVRTDDGGSVDVPGARLRGLLIALALTPGHVVPKAS
                     LVDWIWGEHPPAEATNALQRLVSRLRKVLPDGVVEGQPDGYRLRVEPDAVDAVRFERLV
                     LAGQARTEDSSQRVRLLREALELWRGAALQDVGLQDSAAFEAAVGRLSGLRLTATEERV
                     DTEVALGRGAELVTELTDLVAAHPLRERLVAALMRALVAAGRDSEALLVYQRARDDLAD
                     ALGVDPSPELSALHVALLRGELGRCAETPKTNLRAELTTFVGRGADVAAVRGLIGEHRL
                     TTVIGPGGSGKTRLATETARTLLGDLPDGAWLVELAANGADGDVADVAQSALAGLGLRD
                     ALLGGAPTAELTDRLIAAIREREALLILDNCEHVIESAAVFAHRVLGECRRLRIVATSR
                     EPLGITGEALWPVEPLALPEGDAGPGEIASSPAVQLLRDRAGAVRRDRAVDAGALGTMV
                     RVCRALDGMPLAIELAAARLRTMSLDQLAHRLDDRFRLLTGGSRTALPRHKTLRAVVDW
                     SWELLTDAERMVLRRLSVFSGGASLEAAERVCAGDAVAQEQVLELLTALTEKSLLVAEG
                     DRAPRYRMLGTIKEYAGHRLAEAGESDPARQAHLAYFTELTETAEPHLRHAEQLEWLAV
                     LEAEHDNIGAAMRGALTAGEAQAAMRLAAGAGWYWWLGGHRAEGIELITAATRTPGEVT
                     DEVRAMAYALAVLFVSDGRGDERAAEAWIREAHRFGRRSRRRSPLLGLVDALERLLREP
                     GAFLPAFEPLLDNEDPWVRALARLQLGKMRIVLGQGGRDADAYLEGALAEFRALGERFG
                     ISFALSELAGRIAVRGEFAGACAYFEEAIAVVTEVGAAEDVIRMRSQQARLYRLLGDED
                     ACAGAMAEARRYAERVTWPDALAELALAKAELARWDGDVEEAHSQLGVVTAVLGDGAER
                     PDFRAVRHDLLGYLADDLGAARAHRAAACEAASEAGYPLVIAHVLVGVADLALRRDEPE
                     QAARLLAASAGMRGLPDRSHPDVARIEQTARHRLGDAGFAEAAREGTRTGWSQLVEVAL
                     AR"
     gene            21867..23093
                     /locus_tag="HEK616_RS37720"
                     /old_locus_tag="HEK616_76750"
     CDS             21867..23093
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011595312.1"
                     /locus_tag="HEK616_RS37720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_76750"
                     /product="cytochrome P450"
                     /protein_id="WP_261957750.1"
                     /sec_met_domain="p450 (E-value: 1.8e-26, bitscore: 88.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPVPVPHGLPMERDAGPFDPPRQITRLREARPVSPLIFPDGHQ
                     GWLVTGYEAVRQLMADTRFSSRQDLGVLHVPYETPGMPVATEPSPQVPGLFVAMDPPDH
                     TRLRRKLTGAFTVKRMKQLEEHIVDITERQLDEMARLAPPVDLVKEFALPVPSLVICEL
                     LGVPYADRETFQVNTATFMEKEVPLDEKMAAYGAITTYLAELVTGKRAEPGEDILSDLA
                     RDDDLSIEELTGIAFLLLLAGHETTANMLSLGTFALLQHPEQRAELRADPDLMPGAVEE
                     LMRYLSVADIFYRYATEDLELGGETIGKGSTVVVSLLAANHDPERFENPDTLDVHRKAR
                     GHLSFGHGVHQCLGQQLARIEMRAGFDGLLRRFPTLELAIPADEVKLRTDMNIYGVHEL
                     PVTWTESPR"
     misc_feature    24133..24148
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.18"
                     /tool="antismash"
     misc_feature    complement(24368..24382)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
ORIGIN
        1 ccgatccagg catggcctgg tcgcaccaca tgcgcacggt gacgtcgacc aggtccgtcc
       61 ccaatggtga aggccggacg gcaagcacgg tgacgtcgtt cacgaagtag gaccccatgc
      121 tgacgccttc ggcatccagc acatccagat acgcgttgcc cgctaccgcc cgacgcccgc
      181 cgatgtgatc cagggaagcc aatagcccac cctccggcgc gctccccacc cactcgacct
      241 ggcgccagcc ctcctcctcc aagggggaga acagtccccg ggcctcctgc gcacaacccc
      301 agaagtcgtt ctcgtcttcc tcgctggtga gggcgtaatt ccgcacgtgc accaactggc
      361 ttgctccccc gctgaatccg tcacaaccgg ccgatcctac agatcaggcg atgtgaccgg
      421 cgagctgggc tgacccattg ccctcagtgc gccgagggcg agaggggcgt cacgccgggc
      481 aagggcgatg aggacggcgt ggtcaccgtc ccggcattcg atgacggccg cgtcgtactt
      541 gaacctctgc ttccaggcct gggggtcatc gggccgaagc gctcggacgt gccgcacgac
      601 cagtgtctcc ggaaccgtct tccgggcgac gcgcccatcg ggatccggtg tggtcgccgg
      661 ccgtccgtct cccagcacca ggtggtcgaa gccgtccacc cggtagggaa cgtctccgag
      721 tacggccgcg cgtacgcact gcttgtccgt cggcggaacc ggaacgatgc tgctgacgga
      781 tgcggcggcg cggttgatac gacgttgttg cccccaggca cacagcgcgc ccaggcctgc
      841 ggcgggcagc actgcggccg cggtgatcag gagtgcctcc cgcacgtcgc ggccgaccat
      901 gctcccgaga ctgccggcgc aactcacgac ggtcccggtc accagaccga cggtgagctg
      961 ccggaggctg cggtgcgtcg gggagggtga gtggtggcgg tgccaccagg tgagccacca
     1021 caccatcagc ccgaagggca gcagaaagag accggcgccc agcgggtagc gccagttgcc
     1081 gtccggagac tcccaggtct cctgagcggc ggcacggaac cgcacggtgc ggatctcacc
     1141 ccgccagtac gtcaacttca cctcgtcacc ggcgcgcacg gtgtcgtaga ccggttccga
     1201 cccggccatc cgcacacgcc gcacggtgtc tgtgccccgt tcggtcacgc ggagccagta
     1261 gcggacgctc tttccgctcg gctcgtcctc cgtgcccttg acggtcgccg gaaccgtcgt
     1321 cgtgcacgta tccgaccggg agccagccgg gcaggcgggc gccgcggcgt acgcgtccca
     1381 cttcgccaac tcgaccggca cggtggcgaa cagccctgcc gacagcaaga ggagcaccag
     1441 cccgaagccg acggccagca ggaaccgcca cccgcgctgc gcccccgatg attcccgggc
     1501 tgtctgatct gccatccccg ctgccccctt cttaccgccc ccgcgcgccc tcaacggccg
     1561 cccttccgcc acattgtgcg cctgcagcct tcacctggat gttccgggtg ggctcgcgac
     1621 gtggggagtc gcatggggcc gcagcaggcc gtgactgcac tgcacctcac ggcaccgcac
     1681 tgactgcacc gcactgcctg cacggcacgg cattgccgcg ggctggtcta cgaaaggagc
     1741 gcggccagtc ggtgcaggcg ggcgtaatac cggtggtcgt cctcatcggt gagcaggggc
     1801 aggatcgtgt tgaggtccgc gatgcagcgg cgcaggatcc ggtgccgctc cgcgtcgaga
     1861 gaaccgtcgc cattgcgcca ggcggagacg caccctgcga tgtccgcgtc cagcaacacc
     1921 atgtcgatgc ccgccagctc cacaccgcgc agccggacgg ggaaatccgc ggccacatgc
     1981 tcctgccaca aacgggcgac tgaagggttc acttcttacg cctcgggctc cactcgtagg
     2041 tcatgggagc cgtctcgacg acctcgctcg gccaggcctg ccgcactcgg tccagtcggg
     2101 ctcggtggtc ctggatccag tcgtcctgtg gccggatcca gaagaacgtg gagagccggt
     2161 cggggtcgtt gatggtcact ccgacggacg cgtcctcgtt gagttgaatg cccagctcaa
     2221 ggccccggcc gccgcccagt ccggcgttgc cacgtggcac cagccgttcg agctcctctt
     2281 cccaagcgga cagatcccgc tggaagaggt agagctcaag gcgtgcgtcg aggaagccgg
     2341 tggacaccag gacttcggca cgcagggtgt cgtggcccgt cagaacgccg ggctgatcgc
     2401 gtccagtgac acgaacgatg caccggttgc cgttgccgtc gccgttggcg tcggcgtctg
     2461 ccaggtgtat cagatcgacg ggttcgggct ctcccatagt gcgcctccgc agggccttga
     2521 ctggtgtgcg tagcctgcat cctctcccac ggggcgcgta cgagcagagg cgccccacca
     2581 acgaccgttc gaggcgatcg gagcgccggc tgcggcgggg gtggtgggcc gggtacgggg
     2641 ataacgcctg gtctggttgc gggccgaggt cgcttccacg atggcgtggt gccacgtcag
     2701 gtggcttctt cgaggatgcg agggaagcga ggccgtgatg cgagccgcag ttctgaagga
     2761 gttcgggtcg ccgttgacga tcgagaccgt gcccgatccc gtggtgggga cgggggaggt
     2821 cgtggttgat gtggtggcgg ccggtgtgtt gccctacgcc gcggaggtgt tccgtgggga
     2881 acgccggtat ctgctcacgc tgccggtgat acccggaagc ggggcggtgg gccgggtgcg
     2941 cgccgtgggt ccggactcga cgcggctgcg cgtcggagac tgggtgctgt gtgatcccac
     3001 cattcgcgca cgggacgacg cgttgacccc agacatcaca ctccagggcc tgagtgcccg
     3061 cggggagggc ggcctgcgcc tgcagcaaca cttcgggcag ggctcgttcg ccgaacagct
     3121 gctggtcccg accgagaacg tctttcccct cggcgcgacc ggcgcgaccc gcgcgaccgg
     3181 cgcgaccggc gcgaccggcg cgaccggcgc gaccggcgcg accggcgcga ccggcgcgac
     3241 cggcgcgacc ggcgcgaccg gcgcgaccgg cgcgaccggc gcgaccggcg cgaccggcgc
     3301 gagcgatgcg accggcacga ctggtgcgag cgatgcgacc gatgcggcgg acgcgggccg
     3361 gtggtgtgca ctaccggtcc ttctcgtgcc gtacggcggg ctgctcgccg ccggactgca
     3421 ggccggccag accgtactga tcagcggtgc caccggaaat ttcggaagcg ccgccgttgc
     3481 ggtcgcgctg gccatgggcg cgggttgcgt tgtcgctccg gggcggaacg agaaaatgct
     3541 cggcgagctg gagcgccgct tcgggtcccg catcaggacg gtgcggttgt cgggtgatga
     3601 ggcggcggac cgcgagcgga tgcgggcggc ggcgcccgca ccgatcgacg tcgtactgga
     3661 tctgctgccg ccctcggccg caatgaccgc ggtacgggct gcggtgatga cggtccgcga
     3721 gcacgggacg gtggtgctca tgggaggcgt cggcatgctg ggaggtgacg acctcgccct
     3781 gccgtatccg tggctcatga ggaacaacat caccgtccgc ggccagtggc tgtgcccccg
     3841 ccacgccaac ccccaactca tccgactggc caactcgggg caactggacc tccggcagtt
     3901 cgacgtcacc gcttttgacc ttgccgatgc caacacggcc ttgcggcacg cggctgcgga
     3961 ggggggacgc ttcagcctga cggtcattcg accggtcagg gaagggtgag tgcgtccgcg
     4021 gtcagtcatc ctgtgcatcg cagactctga caacacgcag gcaccgggac gggcatgcgc
     4081 tggctggccc gcccggaggt ccgcttgccc cgtagtcctc tggcgggggg cctttggtgg
     4141 ggccttcttt taccagcgga cggcggtgaa gtcgatgggc tggggtcgga gtaggcgggt
     4201 gcgttctgtc agtgattcca ggcgccggga catctcgtcg gcgggtaggt ggtggcggtt
     4261 gccgtggccg gggaggaccc attcgaagcg cagttgtggg gtcgtcctgg cgagggagtt
     4321 ggccagttcc tcgatggagt accaggtcac gttctcggcg acctccagat cgcccgtggt
     4381 gcgggaccag tagaagctgt ctccgctgaa gcagtaccgg tcgtcggcga ggtagagcac
     4441 gctgccccgg gtgtggccgg gcagggggtg agcggtgact ccctcgccga tgtcgacggg
     4501 ttcgagtccg cggatcacct ggtccgcgtc cggcgctgcg tcgaggtcgc cctcgtggat
     4561 ccacagccgg gcgccgaagt ggtccgcgta gcggcggccg tgggcgacgt ggtcgcggtg
     4621 ggtgagcagg acgtcggtga cgggtcccaa cgcggtgtag cgagctgcca gttcacggct
     4681 ccagcgcggg gtgtcgatca tcatgaccga gccggagggc cgcaggagga ggtaggagtt
     4741 ggcgccggcg gtgtcccggg agttgtggcc gcagaccagg acgccgtcgt ccagggccat
     4801 cgggaagggg tcgagggtgc ggtcggccag cccggacgcc gggcggatcg agcgggtggg
     4861 gcaggcgaag acggcggcgt gtaggcgccg gttctccgcc tcgtcgcggg gctggcgcag
     4921 gatctgcgac ttgccgtcgg cttcggtgat caggtcgggt gcgaactgtc gggcgacgtc
     4981 gcagttggtg cagcggtcgt cgacgtacca gttctccatg gaggggctcc ttcgggggga
     5041 acggacccgg accggggccg ccctttcagg attacccgcg tgcggccgat atcggtagac
     5101 ctcgccgatc ttgtacttct gggcccgaat cgctctcacg gctcggtcgg cggggagggt
     5161 tttggtgggg tttgcggctt ctgtgcatcc cgcaacagga cggcgtcgcc ccccgattgg
     5221 tctcggcatc ggagagccgc gtcgtgagac ggaggcgggg tacctcggag aaggtggcga
     5281 cggatgcgtc ctgcgggtac tcacgcgagg actcgatggt cgggaggtga cgggctggat
     5341 ggatgcaggc cgtgtggcga ggcagggcgc gcgtaggtgg gcgagggcgg ggcggatccg
     5401 gctgatcgac acccatgtca gtgaatttcc ggagtgtggc gcagtttttg ggaacccggc
     5461 tccgtcggcg cgcctcctct ccctcagaga cgcatagctg gtgcgtccac gttcgatgtg
     5521 ggggcgagac atgacagcac gtacagcgca acggcccgta ggagcgcggc gggcggtggc
     5581 cggtacgacg gtggcggccg cggccggact ggttttggtg gtcggggtgg cggctcccgg
     5641 gcaggccgcg cccgttcagg cggccgccgg aacacagtcc acgtccgcgg cgagctgcgg
     5701 cggtgcggtg acggcagtcg agagcggcca cgcaacgcgg atgacgtcca cagcggcacg
     5761 gacggcttcc ccggggcggg gagcttccgc ggggcgagtg gcttccgcgg ggcggacgga
     5821 ggcagctctc ccggttgcgg gcgccaccgg gagagcggcc gagaagttct cgtacagtct
     5881 cgcctcggag gcgccggtcg ggctgtggac gtcctccggg gtgaccctgc ggacgccggt
     5941 ctccaagggc accgtccgcc tggacgtcac cacccgcggc ttcagcgccg cctccctcat
     6001 gatccagcgc tacgtcccca agacccaccg gtgggtggat ctggatcagc ggccggtcgg
     6061 tagcgaacat ccggagaagg ggacgttcac cttccccgtc tcggtggccg cgagcgccgg
     6121 tcaccccgcc acggtggccc tgcgcgtgca ggacatcgac cggcccggcc gcctgacggt
     6181 ggccgcctcg gtcagggacg ggcacggcca cacgtaccgc gcgccggcca ggagtgccgt
     6241 cgtcgaccgg ccgacgacca cgatcacggg ctggtcgcgc ggcaccgcac tggtccccgg
     6301 tggcgcggcg aaggatttca ccctcgcggt caagaacacc accaagcggg cctacccggc
     6361 attgaacgcc ggctacttcg cctacggcca gggcagcggg cgtgccgtgg agccgaagga
     6421 cctggtgctc cagcagtacg tgcccggtca cggctggcag cgcgtgtcgc tgctgcccgg
     6481 tggctgcgac cccggtatgg ccgcccagct gatcccgacc gccaagacgc cgctggcgcc
     6541 gggcgccacg gccgtctacc gcctgcgcct ggcggtcgcg gactccgctc ccgtgaccga
     6601 tgtcgacgcg ggtgtgtcgg tgggcaccgg tgacacgtcg ttcttctacc ggaccctgcc
     6661 gttcgagatt cgcgccaagt agcgtccgcg ggaacggccg taggcgttcc acgtagcgtc
     6721 cgcggtaggt gacttctggg cgtcagctcg accgggtggc cgtcggtatc gtgccggcgg
     6781 cctgccgggc gagggcggtg cggatcaggg cgttgacggc ggcgggctgc tcctggtgcg
     6841 gcatgtggcc cgcctgctcg atcgcgtgga actccccgta cagagccagc gcggccaggg
     6901 tccgggacac gtccagcggg acctcggtgt cgagtcggcc gtgtatgaag agggccggga
     6961 ccgtcagccg gccgatgtcc gcgcgcgggt cgtggaggtt gctctccgcg aacagctcgt
     7021 cgatgaacac gccggatcgc aggatctgcc gcctggtctg ttctgccagg gccgggtcgg
     7081 ccgtcggggc gaaccattgc gggacccagt cggcgagagc cgccgggcga tcggcggcca
     7141 gcgccgcgcg cagggcgcgg agcggggccg ccatgccctg gctgggccag tagccggggc
     7201 cgctgatcga caccacgccg cccacccgct ccggtgcccc gagtgccgcc tccagggcga
     7261 aggtggcacc gagcgagctg cccaccaaca agggccgatc caaggccagt cgatccatca
     7321 gggccaggat gtcggcggcg ttggtggcgg tggtgttccc ggtggccggg tggtcgctcc
     7381 ggccgcagcc gcgccagtcc acggtcacca cccggtggtc ggcggccaga tcggcgacct
     7441 gggcgcccca cacccgtccg ctggttcccc agccgtgcag gaacagcacc ggtatgccgg
     7501 tcccgctgtc cgtgtagaac aaccgggttc cgttcgccgt ggcgtacggc atcgtcactc
     7561 acgctcctcg tcgatgtgtc gcggctcggc tcatcgcgtt tcgtcgcgtt gtgtccgctt
     7621 cgcccgcccg tgggcggcgg tgatgagcgg gaccagttca ctgtgggggg cgggcgcgac
     7681 caaggggcat tcggcttcca cactcatcaa gaagcgtgat gaatccggga gggcttgtcg
     7741 ccgagcgtcc gctgcgcatc gttccccgcg agacccacat tgcgggtgtc tgtccctgcg
     7801 gtagcagtcg gataacttct gcgttcagcg gtgtaccggg gcagaaggcc caggtaggtt
     7861 cagcgcccat gacagaggac gtcgtggaca tcgaccggca gcagctgatg gtggaggcgc
     7921 tccaggaatt cgcggcgcgc agtgacgagc agttggactg gaccctgggt ctggtccggc
     7981 accggctcgg ggctgcccgc cgattggggg ttccggtgcc ggaagacctg gccagcaggg
     8041 tggcgcggct ctgcgagaag cggaacttgc cgctctacga gccggagcag cgggactgag
     8101 gccggtgtcc gttgcccttc gcgcggcggg tgaggggaag gccggccccg ccgccacccg
     8161 acccgacggt gctgcccgcg cagcgaccgg ggggtttgcc ggtgggcgtc cggggcggtt
     8221 acggcgattt cggtgcgggt cgtggtcaag tgagggctgg ccccggccac gcccccgtgg
     8281 cgcgtccagg ggcgtaggcg gggctgtgac gtgccggaac gcggtgcggc tgccccttgg
     8341 ccggcgagac cgtgaggagg tgcgatgcgc cgtagtggcg ggaccgcacc ctgcgcccca
     8401 ctctgtgctg cgcgggctga cagcgttgac agtgacggtg acggtgaggg cgatggcgga
     8461 ggcggagtcc ggtgaggacg cttccagggc ccaccgatca cgtcgtggtg gtcggggccg
     8521 ggctctccgg attgtccgcc gcgctccatc tgctcggggc gggccgccgg gtgaccgtcg
     8581 tcgagcgggc cgagctgccg ggcggacggg ccgggcgggt cgaccgcggc ggctaccgca
     8641 tcgacaccgg accgaccgtg ctgaccatgc cggacctgat cgaggaggcg ttcgccgccg
     8701 tcggtgagcg gctgtcggac cgggtggtgc tggaccagct gcacccggcg taccgcgccc
     8761 ggttcgccga cggcagtgag ctggacgtgc acaccgaccc ccgggccatg gaggccgagg
     8821 tggagcggtt cgccggaccc cgcgcggcgc acggctaccg gcggctcagg cggtggctgg
     8881 agcaggtgta ccgggcccag caccgccgtt tcatcgacag caacttcgac tcgccgctgc
     8941 aactgctgca cccggacctg gcgcggctgg ccgcgctcgg cgggttcggc cggctcgacg
     9001 accgcatcgg ccggttcgtg cccgacccgc ggctgcgcag ggtcttctcg ttccaggcgc
     9061 tgtacgcggg ggtgccgccc gcccgggccc tggccgcgta cgccgtcatc gcctacatgg
     9121 acacggtcgc cggggtgtac ttcccgcgcg gcggcatgca tgcgctgccg cgggcgatgg
     9181 cggacgccgc cgctgccgcc ggggccgcat tccgctacgg cacgcccgtc acccggctgg
     9241 aacgcaccgg cggccggatc accgcggtgg tcaccgagca cgagcggatc gcctgcgacg
     9301 cggtggtgct cactccggac ctcccggtca cctaccggct gctcggccgg cggccccggc
     9361 gtccggtccg gctgcgccac gcgccgtccg ccgtggtcct gcacgcgggc ggcgcacgga
     9421 cctggccggg caccgcgcac cacacgctct ccttcggcgc ggcctgggag cgcaccttcg
     9481 acgaactcac ccgccgcgga cggctgatga gcgatccctc gctgctggtg acccgcccca
     9541 ccgcctccga cccggcactc gcaccgccgg gccgccatct gcactacgtg ctggcgccgt
     9601 gccccaacac cgagaccgga ccgggcgccg aggcctggcc cgcgctcgcc ccccggtacc
     9661 gcgacagtct gctgtcgctg ctggagcagc gcgggttccg cggaatcgcc gacgccgagg
     9721 acctgggcac ggtgacgccg gccgactggg cggcgcaggg cctggcggcc ggcacgccgt
     9781 tctccgccgc gcacaccttc gcgcagaccg gcccgttccg cccgcgcaac ctcgtacgcg
     9841 gcaccgagaa cgccgtactg gcggggtgcg gcaccacccc cggcgtgggt gtccccaccg
     9901 tgctgatctc gggcaagctg gccgccgccc gggtgacggg cctccgtccg ccgcgttccc
     9961 gcgccggcgc gccgcggccg ggcgacagga cggtaccggc atgacggagc gcgaactgac
    10021 cgcggcgggc atcaccgatc cccgcctgcg cgccgactac gcccactgcc gccggctcaa
    10081 cgcccggcac ggccggacgt acttcctggc cacccggctg ctgcccgcgg accggcggcc
    10141 ggccgtgcac gccctgtacg gattcgcccg ccacgccgat gacctcgtcg accacccggc
    10201 caccggcagc agtaccgccg accgcgcgcg ggcgctctcc gcgctgcacc ggaacctgca
    10261 gaacggtctg cgcggcgatc cgagcccgga gccggtcgtc cgggcggtgg cgcacaccgt
    10321 cgccgcgtac gacatcgacc acgcccactt cgccgacttc ctcacggcga tgcggatgga
    10381 cctggtcgtc acggactatc cgacctacgc ggacctgcgg tcctacatgc acggttcggc
    10441 ggcggtgatc ggcctgcaga tactgcccgt gctgggcacc gtcgtcccgc gccacgaagc
    10501 cgccccgcac gccgccgcgc tcggcgtcgc cttccagctg accaatttcg tgcgggacgt
    10561 cggggaggac ctcgaccggg ggcgcgtcta tctgcccgcg gatctgctgg cggcgcacgg
    10621 tgtcgaccgg gcgctgctgc ggtggagccg ggacaccgga cgcccggaca cccgtatttc
    10681 ccaggccctg gcggccgcgg ccgaactcac ccgcggcgtc taccgggagg ccgcccccgg
    10741 cctcgccatg ctcgacccgg tggcgcgccc gtgcatgcgc accgccttcg tgctctacgg
    10801 cgccatcctc gacgcggtgc gcgaggacgg gtacgccgtg ctgcaccggc gcgcggtggt
    10861 ctcccgccgg cgccgcgcgg ccaccgcact gggcgggctg gcccgatccg tcgcggcccg
    10921 tctgaccgcc cggccgccgg ccgcgccgcg ggaacggacg ccgcagccgg cgcagaagga
    10981 gagcgcatga gcccggacgg ccgtcaccgc ccacgcgtcc cgctgcggct gcggcgcggg
    11041 ccagaacggt gggagcggca gcggtccacc tggcgggagg cccggcccgc cgtcatcgac
    11101 ggggcgctga aacgggcgct cgcccgacgg tcgggcaact ggttcgtgct cggcgcggcc
    11161 cgtgacgtgg agccccggaa gccgttcggc cggacggtgg ccggcgtcga ggtggtcgcc
    11221 tggcgcgatg ccgccgggcg actggtggcc gggccggggg cgtgcccgca cctcggggcg
    11281 ccgctggcgg agggtgccgt gcactgcggc acgctccgct gccgctggca cggcctcgcc
    11341 ctggacggtg ccgcgttcgc cggctgggaa ccgttccccg cccacgacga cggagtgctg
    11401 gcctggatcc ggctggacgc ggccggcggc gaacggcccc tgccgcggcc ggtgctcccg
    11461 ccccggcccg gaccggccgg cacgctcgtc gccgtgcaca cggccgtcgg ggcgtgcgaa
    11521 ccggaggacg tggtggccaa ccggctggac ccctggcacg gggcgtggtt ccacccgtac
    11581 gcgttcgtgg acctcagggt ggtcggcgca ccgacggagg ccggcaccga gggcccggac
    11641 gagttcctgg tcgaggtctc cttcaaggtc gccgggcgtg cggtcgttcc ggtgacggca
    11701 cgcttcacgg cgccggagcc gcgcacggtg gtgatgcacc tcgtcgacgg cgaggggaag
    11761 gggtcggtgg tcgagaccca tgccacgccc ctggccccgg acgaccgcgg ccggccgcgc
    11821 accgcggtgg tcgaagcggt cctggccacc tccgaccggc ccgggttcgc gttggcccgc
    11881 gccgcggctc cgctcgtgcg cccgttgatg cgggcggccg ccggccggct gtggcgggac
    11941 gatctcgcgt acgccgagcg ccgttggcag ctgcgccgga gcggccgcta tccgggctga
    12001 cggccgctgt tcgggctgac ggctgctgtt cgggcgaccg ggccgaggca cgaaggacga
    12061 ggtgcgacgg gccgggggcg gtcagtgtcc ggtgcgtccg gccgcccacc gcagcggcgc
    12121 cacccgcccc ttgtccggca cggtccacag ggggtgaccg cgcacgcccc agcgggccaa
    12181 cagggcgttg gccgccagga acccggtggt cgccgcgcgt tccatcagcg ccaccggcag
    12241 tgccgtgcgc accaggtcgc cggcgaccac cacccggggg tcgggggtgt ggacggtggg
    12301 ccggtcggcg tggccgccca ccgcgaacag cggacagtcc gcccgccact cgtggcgctg
    12361 gtcgacgatc cgcgccccgc gggtctccgg gtagacggcg tgcaactgct cgaccagacg
    12421 ccgctgttcg tgcgcccggt cggcgtccgg ccgcaccgcg taggcatgca gttcgaggac
    12481 cgaaccgccg gtgcggccgg accagcgggc ggcctccccc tcccagcgtt ccagcacgct
    12541 gatgttgtcc agcgaaccga agccgctggt gcccaggaag ccggcgcggt cgggggacac
    12601 cggccgcgcc agccacagcc gggacaccag gaagggcggt gcggtgcgca gccgtccgat
    12661 gcgcgcccgc cacgcggggt cccccaggcc gtcggatgcg gccacgatcc gccgcagacc
    12721 ggcggtgtcg accgcgagca ccacggcgtc gtacgggtgc gacccgctgt tcgtcgccac
    12781 gtgcacccca ccgcccgcct gcggctcgac gcggtccacc ggcgtgccgg tgcgcagccg
    12841 tacgccgtgc ccttccaggt accgggcgag cggcgcccac agcgcctcgg ggtacggctc
    12901 cgcgggcacg tcgaacagca gcccctcgct cgacccgagg aagtagatgt ggaacatcaa
    12961 cgccatttcc gccgcggaca gttggcgagg gtcggcgaag aagctgcggg agaacacctc
    13021 gaacgcgagg tggcgcgcgg cctcggggaa gccgatgcgg tccagcaggt cccaggcgct
    13081 ggtgtcgtcg agccgctggt agatctgcgg cacccgtacg tcgagcagcg gcagggccgc
    13141 ggcggggcgc atccgggcca ggtcccgcca ggcgaaggtc gggctgaggg ccatgaagcc
    13201 cagggcgctc cagggcggtg tgcgcggtac gcgggcgaag ctgtcgcggg tgcccgagcg
    13261 gtgctgcagc ggatagtccg ggagccgtcg cagcacccgg agtccggggt cgatgcgccg
    13321 cagcagcccc cgcaggttgt agtactgggg gaagaaggcg tggaatcccc ggctcatggt
    13381 cgccgccgag ccgtcggcga gccgcaccgg ccaccccgcc agccggcccc cgaggacgcc
    13441 ttcgcgctcg tacagcgtca cccgcactcc gcgctcggcc agtgcggtcg cggccgccag
    13501 accggcgatg ccgccgccga tcaccgctac cgcgggccgg ccgtcggccg ccgcccggtc
    13561 gttccccggt ggccccggca gcacccgcgc gcggcggtcg cggccgcgcc gggcgctcac
    13621 ggcccctccc gggccggccg ccccggtcac cacggggccg tcttccgggg cagcagcggg
    13681 agttcggcga cggtgcggag catggggagc acgggggtgc gcagcccgat ggtcaggtcc
    13741 tcccagagcc gggagcgtcc gtcgaggaac cgcagcagac gctcggtggg caccgcgccg
    13801 aacaggtcgg tgaagaccgc cgcgccgtcc acccgtccac tgtccagccc gcgcagcagc
    13861 acggcgtcca gcgcccgggc ccagcggctg tgcaccggcg gtggcggggg cgacccgggt
    13921 tgccggagcg cggcggcgag gcccgcggtc tggcgctgca ccgcggcgaa ggtgtatccg
    13981 gtcgacgggc gggtggcgcc gccggcggtc ccgatgcgga acaccgaacg ccccgcccgg
    14041 tgcggaaacc ggccgtcggt catcgggatg acgccctgtt ccgtgcccgt gatctcgaac
    14101 gggccgagct tgcgcacctc gtcggtgtaa tggcgcaacg ccctttcgta gccggcgaca
    14161 tccagcggcc gccgggagaa ccgggtgtac tcgaccagcg ccgtgtgcgg gtccagcggc
    14221 aggacgtacc cgaaggccag gccgtgggcc ggctgcggaa cgcggaagtc catccagtcc
    14281 gccacggccg ggtcgaacac cgctctccgc gtacggacga accagccccg gaagtgctgc
    14341 cgcagtgtgg tccgggcggg cgggagcagg gatccggggc gggagtcgaa gacccagcgg
    14401 gaccgcagcg ccaccgggcg cccggcacca tcacaccccc gcacctcggc gccgtcggcg
    14461 gtgtcgcgca ccgccgccac cgtcgcctcg acgcgccgca cggcggggtc cccggccagc
    14521 cgggcctcga cgacggcggc gaaatcgccc gatcgcagca tcttgtaccg cagcggcgcg
    14581 ggccatccca ccgtctccgt gccgtcggga ccgtacaccc gcaaggcgtc ccacacggcg
    14641 gtgagcgccg ggtcgaactc gccgccgggc ggctcccaga agcaccaggt ccgttccggc
    14701 ggtgtacgcg gcccccgcgg cgcctccacc agcaccacgg tcggccgacg tgccccggca
    14761 cccggtgcgc acaggcggta ggccagcgac agccccgccg ctcccgcccc gacgatgacc
    14821 acatccgcgt cccgcacacc cgtccttccc tgcccggctg ccgagcgccc cacgacggcg
    14881 ctcgccaccg gcgaccgctg acgctcgcga cgatccttcc gcagccggga cccggacgac
    14941 ggccgccacg cgcggcgagg cgggggaatg ctgggggtgg ggcctagaag gggtgctgac
    15001 ccatcggaca gggcctagcg tcctcgcggc ggcacgagct tgactccgaa gcagtagagg
    15061 gccgaggcga cggcgatgcc gacggggagg gcgaggttga tgccgtgcag ggcgcgggcg
    15121 acggggccgg tgtagagggt gttcatgcag agggcggcgc aggcggtgcc gccgatgagg
    15181 gcggtggcac ccgccgcgtt cacgccgccg gtgtaccaga aggggctgcc gggggtctcg
    15241 tccgtgagcg cggggccgtc gtagcggttg cggcgcagca ggatgtcggt ggcgtagacg
    15301 gccatggtgg ggccgaggag gccgacggtc agctggagga cgttgctgac ggtgtcgagg
    15361 aagttggaga ccagcagcgc gtacagggtg agggagacgg agacggtgcc gtcggcgagc
    15421 acgctgacgg agcgtcggat gcgcaggccg acggcctgga gggcgagtcc ggcgctgtac
    15481 gcggtcagcg cgttgagggc gacggtgccg aggaccaggg cgaggaggaa gagcggcacg
    15541 aaccagccgg ggaggatctt ctccagcgcg tgctgcggat cggtcatgtc gaccgcggtc
    15601 gcggcgaacg ccccgagcga gcagacgacc acgctgggca ggaagccgcc gaaggccgtc
    15661 caccccacga tcgccttcgg ggacgcggtg cgcggcagat agcgggagaa gtccgcgctg
    15721 gtggtgtacg acagcgggcc cgaggcgatg agcgtgacgc cgccgaggag ggcggcccac
    15781 cggctcgtgc cggcgagcgg ctcggtgggg gagtacgaga aatcggtgtg ccggagcacg
    15841 tagcaggcga ggaccgcgaa gaccgcggtg agggccaggg tgatcgggag gtacagcttc
    15901 atgatcaggg cgtggccgta gacgctgatg gtgagggtga gggcggcgac ggcgatcacc
    15961 acggcgatct tgacgccggt ggtggtcggg atgccggccc gttcgacgag ggagaaggcg
    16021 gccgtcgcgg cggcggccag gttgagggcg aagtagcaga cggagaccag ccatccggtc
    16081 accgcgttgt tcacccggtt tccgcggatg ccgtacatcg cccgcgtgat cacttcgctc
    16141 ggggcgccgg cggccgggcc ggacacggcg agcagcccgg tcagcagcca gaagaggacc
    16201 cggccgcccg gcgcgcggag atcgtcgccg cggcggcagc cgtcgccctg accgaggggc
    16261 tggagtgcgt caccctccgc agaatcggcg aggaactgga cgtccggccc ggcctgatca
    16321 gccactactt cccgtcggcc gaggacctgg tggcggaggc cttcggccac gccgccaccg
    16381 gcgagctgga cagcctcgtg cccgtcgagc gtcccgaggg cagcccgctg cggcatctgg
    16441 cccggttctt cgcgcaaacg acgggggagc gatacgacgc catcagccgc ctctggctca
    16501 acgcacgcca cctcagccgc taccgcccgg tgctccgcga ccgggtcgcc gtgcaggagg
    16561 ccggatggcg cggccggctc tccggcctcc tccaggaggg cgtcgagcag ggtgaattcc
    16621 acaccgacga cccgcaattg acggccattc agatcctggt ggtgctcgac ggactcggag
    16681 cccacgccaa caccgaaacc ggcagccacc ccgaggccgt gacccgcatg gccatcacca
    16741 cggccgaacg ggaactcggc ctggccgacg gcgccctcac ccgccccacc gatgcgtccg
    16801 gcgcgtgagc ccccgaaaac gcaccgctcc gccaccgcac gcccggtagc ccctgcccgt
    16861 accctccccg ccctccccgt tttgaggagc cgctgtgcgc accccgctcg tcctgctctc
    16921 cgcccgtctg ctcgacccgg tcagcggtgc cttcctgccg gacaccgcgc tggccgtgtc
    16981 cgacgggcgg atcgcctccc tgggcgacga ccgcgacatc cgggcactcg ccggcccctc
    17041 gacgaccgtg atcgacctca agggcgccgt ggtgaccccc ggcctcgtcg acgggcacct
    17101 ccaccccgtg tccggcgccg aactcaccca cggactggac ctgtcgggct gtaccgacct
    17161 ggagtcggta cgcgaggcgc tggcgcgcga ggtgcgccgc ctcgcccccg gcgcctggct
    17221 gcacggctgg ggcctggacc ccaacgtctt cggggaccgg ccggtggaat ccgccgccct
    17281 cgcccccgtg ctcgacggcg taccggcctt cctcctgctc ttcgacgccc actccgcgct
    17341 ggccagcgag cgggccctcg aactcgccgg ggtcgacggc ccgcggcgct tcgaccaggc
    17401 cgccgaggtc gtctgcgacg acgcgggccg gcccaccggc ctgctgctgg aggacgccgc
    17461 ctgcgagctc gtggaacgcg tcgccccgca gcccacccgc gaggaacggc gcgcccgcct
    17521 cgccaccacc ctgcgcgcca tggccgcggc cggcctcacc ggcggccacg ccatggacgc
    17581 gaacggcgac agcctcgcct tctacgccga actcgacgcg gccggcgaac tgccgctgcg
    17641 cctgcgggtc gcgccgtggt gccagcccgg taccgacgcc gccgggctgc gcgcgctcat
    17701 cgacgggcag ggcgccggcg gcacgctgtg gcggaccgcg ggcgtcaagc tcttcatgga
    17761 cggcaccatc gacaacggca ccgcctggct ggaacgcccc gactgccacg gcgagtccac
    17821 ccacgccttc tggccggacc ccgacgccta cacccgcgtc atcggtgagc tccacgcggc
    17881 cggagtgccc accgccaccc acgccatcgg cgacgcggcc gtccggcacg ccctcgacgc
    17941 cgtcgagaag gcccaggccg acggccgccg cggggtgcgg caccggatcg agcacatcga
    18001 gaccgtcccc gacgacaccc tgcgccgctt cgcccagctc ggcgtcatcg cgtccatgca
    18061 gcccacccac tgctgcgact tcacccgggc cgaccgcacc gacaactggt cacgccgcct
    18121 gggcgaggag cgtgcctccc gtgcctggcg ctgccgggac ctgaccgacg ccggagccac
    18181 cgtcgtcctc ggctcggact ggcccatcgc cccctacccg ccactgggcg tcctggcggg
    18241 cgcccgccac cgccgcccca gccgcgacct cacccggccc ccgcacggcc ccgaccaggc
    18301 actcacgccc ctggaggccc tccagggaat gaccgtcaac gccgcccgcg ccgcgggcga
    18361 ggagcacgag gccgggcggc tcgccgtcgg ccaccgcgcc gacctcaccg tcctcgccga
    18421 cgacccgctc accacccccg ccaccgacct gcccgacctc cccgtgctgc tcaccgtcct
    18481 ggacggccgc ccgacccacc gcgacaccag cctgtgaggg cacgtgcggg cggtcgccgc
    18541 gttcagcgag ccaacgcgac ctcgaccagc tgagaccagc cggtccgcgt cccctcccgc
    18601 gccgcctcgg cgaaccccgc gtcgccgagg cggtggcgcg cggtctgctc gatccgggcc
    18661 acgtccgggt gggagcggtc cggcagcccc cgcatgcccg cgctcgccgc gagcagccgc
    18721 gcggcctgct cgggctcgtc gcggcgcagc gccaggtccg cgaccccgac gagcacatgc
    18781 gcgatcacca gggggtatcc cgcctcggac gccgcctcgc aggccgccgc acggtgcgcc
    18841 cgggccgcgc cgaggtcgtc ggcgagatag ccgagcagat cgtgtcgcac cgcgcggaag
    18901 tccggccgct ccgctccgtc gcccaatacg gccgtcacga cgccgagttg actgtgcgcc
    18961 tcctcgacgt cgccgtccca ccgggcgagt tcggccttcg cgagggccag ctcggccagc
    19021 gcgtccggcc aggtgacccg ctccgcgtag cgccgcgcct cggccatggc gcccgcgcag
    19081 gcgtcctcgt cgcccagcag gcggtacagc cgtgcctgct gcgaccgcat gcggatgacg
    19141 tcttcggcgg caccgacctc ggtgacgacc gcgatcgcct cctcgaagta cgcgcacgca
    19201 ccggcgaatt cgccgcgcac ggcgatccgg cccgccagct cgctcagcgc gaacgagatc
    19261 ccgaaccgct ccccgagcgc ccggaactcg gccagcgccc cctccaggta cgcatccgcg
    19321 tcgcgaccgc cctggccgag cacgatccgc atcttgccca gctgcagccg ggccagcgcg
    19381 cgcacccagg gatcctcgtt gtccagcagc ggttcgaacg ccggcaggaa cgcaccgggc
    19441 tcccgcagca ggcgttccag cgcgtcgacg agccccagca gcggggagcg acgccgactg
    19501 cgccggccga accggtgcgc ctcgcggatc cacgcctccg ccgcacgctc gtcgccccgc
    19561 ccgtcgctca cgaacaacac ggccagggcg tacgccatgg cccggacctc gtcggtcacc
    19621 tcgccgggcg tcctggtcgc cgcggtgatc agctcgatgc cctcggcccg gtgcccgccg
    19681 agccaccagt accagcccgc gcccgccgcg agccgcatcg ccgcctgggc ctcgcccgcc
    19741 gtgagcgctc cgcgcatcgc cgcaccgatg ttgtcgtgct cggcctcgag cacggccagc
    19801 cactccagtt gctcggcgtg gcgcagatgc ggctccgcgg tctcggtgag ctcggtgaag
    19861 taggcgagat gcgcctggcg cgccgggtcc gattcccccg cctccgcgag ccggtgcccg
    19921 gcgtactcct tgatcgtgcc gagcatgcgg tagcgcgggg cacggtcgcc ctcggcgacc
    19981 agcagcgact tctcggtcag cgcggtgagc agttcgagca cctgctcctg cgccaccgcg
    20041 tcgcccgcgc agacccgttc ggccgcttcc agactcgccc cgccggagaa caccgagagc
    20101 ctgcgcagga ccatccgctc ggcgtcggtg agcagctccc agctccagtc gaccaccgcg
    20161 cgcagcgtct tgtgccgcgg caacgcggtg cggctgccgc cggtcagcag gcggaaccgg
    20221 tcgtcgagcc ggtgggccag ctggtcgagg gacatggtgc gcaaccgggc cgcggccagt
    20281 tcgatcgcca gcggcatccc gtccagcgcc cggcagacgc gcaccatcgt ccccagtgcg
    20341 ccggcgtcga ccgcgcggtc ccggcgcacc gccccggccc ggtcccgcag cagctggacg
    20401 gcgggtgagg aggcgatctc accggggccc gcgtccccct ccgggagggc cagcggctcg
    20461 accggccaca gtgcttcccc ggtgatgccg agcggttccc ggctcgtcgc cacgatccgc
    20521 agccgccggc actccccgag cacccggtgg gcgaacaccg ccgcggactc gatgacgtgc
    20581 tcgcagttgt ccaggatcag cagcgcctcc cgctcgcgga tcgcggcgat gagccggtcg
    20641 gtcaactccg cggtcggggc cccgccgagc agggcgtccc ggaggccgag cccggcgagc
    20701 gccgactgtg ccacgtcggc cacgtccccg tccgcgccgt tggcggcgag ctccaccagc
    20761 caggccccgt ccggcagatc gccgagcagc gtgcgcgcgg tctccgtggc cagcctggtc
    20821 ttccccgagc cgcccggccc gatcacggtg gtgagccggt gctcgccgat gagcccccgg
    20881 accgcggcga catcggcgcc cctgccgacg aaggtggtca gctcggcgcg cagattggtc
    20941 ttcggggtct ccgcacaccg ccccaactcg ccccgcagca gcgcgacatg caacgcggac
    21001 agctccggcg aggggtcgac gcccagcgcg tcggccaggt cgtcccgcgc gcgctggtac
    21061 accagcagcg cctcgctgtc gcgaccggcc gcgacgaggg cccgcatcag cgcggcgacc
    21121 agccgttccc gcagcgggtg cgcggccacc aggtcggtca gctcggtgac cagctccgca
    21181 ccgcgcccga gggccacctc cgtgtcgacc cgctcctcag tggcggtcag gcgcaacccc
    21241 gacagccggc cgaccgccgc ctcgaacgcg gcgctgtcct gcagaccgac gtcctgcagg
    21301 gccgccccgc gccacagttc gagggcctcc cgcagcagtc gcacccgctg cgaactgtcc
    21361 tcggtgcggg cctggcccgc gaggacgagg cgttcgaacc gcacggcgtc gacggcgtcg
    21421 ggctccaccc tcaaccggta accgtccggc tgcccctcga ccaccccgtc cggcagcacc
    21481 ttccgcagcc gggaaaccag gcgctgcagg gcgttcgtcg cctcggcggg cgggtgctcc
    21541 ccccagatcc agtcgacgag cgacgccttc gggaccacgt gacccggcgt gagcgcgagg
    21601 gcgatcagca gtccgcgcaa ccgcgcgccc ggcacgtcga ccgagccgcc gtcgtccgtg
    21661 cgcacctcca agggccccag catcccgatc tgcacccgct gattttgcca cgggccttgc
    21721 gggggccttc agttgctgac gggctgaggg acatcggtgc ccctggccga ccgcgcctcc
    21781 cgcatgatcg gtgtcagagc cgtgtcagtc ggatgtcagg accgtcggcg atcgtggccg
    21841 gaacaaccgc cacgaaagga aaaccgatga gcgagccggt tcccgtcccg cacggcctcc
    21901 ccatggagcg cgacgcgggc cccttcgacc cgccccgtca gatcacccgg ctgcgcgagg
    21961 cccgcccggt cagtcccctg attttccccg acgggcacca gggctggctc gtcaccggct
    22021 acgaagcggt ccgccagctc atggccgaca cccggttcag ctcccgccag gacctcggcg
    22081 tcctccacgt gccgtacgag acccccggca tgcccgtcgc gaccgaaccg tccccgcagg
    22141 tgccgggcct gttcgtcgcc atggacccgc cggaccacac ccggctgcgg cgcaagctca
    22201 ccggcgcctt caccgtcaag cgcatgaagc agctcgaaga gcacatcgtc gacatcaccg
    22261 agcggcaact ggacgagatg gcgcgcctcg ccccgccggt cgacctggtc aaggagttcg
    22321 cgctgccggt gccctcgctg gtgatctgcg aactgctcgg tgtcccctac gcggaccggg
    22381 agaccttcca ggtcaacacc gccacgttca tggaaaagga ggtgccgctc gacgagaaga
    22441 tggccgcgta cggcgcgatc accacgtacc tggccgaact cgtcacgggt aaacgcgccg
    22501 agcccggcga ggacatcctg tccgacctgg cccgcgatga cgacctcagc atcgaggagc
    22561 tgaccggcat cgccttcctg ctgctgctcg cgggccacga gacgaccgcc aacatgctgt
    22621 cactgggcac cttcgcgctc ctgcaacacc ccgagcagag ggccgaactg cgcgccgacc
    22681 cggacctgat gcccggcgcc gtcgaggaac tcatgcgcta cctgtccgtc gccgacatct
    22741 tctaccgcta cgccacggag gacctcgaac tcggcggtga aacgatcggc aaggggtcga
    22801 ccgtcgtcgt ctcgctgctg gccgccaacc acgaccccga gcgcttcgag aaccccgaca
    22861 ccctggacgt ccaccgcaag gcccgcggtc atctgtcctt cggccacggc gtccaccagt
    22921 gcctcggtca gcaactggcc cgcatcgaga tgcgcgccgg tttcgacgga ctgctgcgcc
    22981 gcttcccgac cctcgaactc gccatcccgg ccgacgaggt gaagctcagg accgacatga
    23041 acatctacgg cgtccacgaa ctgccggtca cctggacgga atcgccgcgg tagggccggc
    23101 gggcggcggc acgcgtggcg acggccgccg cacccctgtc attccgtttc cgtcaccgtc
    23161 cggtgcgctt gatggcgtac gtcagggtgc ggatgccggc gtaggaagcg caggagggtc
    23221 cgccattcct cgggccagcc gaggctgccg ccggttccgg ttgccagttc ggccgccagc
    23281 aggccgggga cggcgccgcc gtcgcgggcc agctcatcgg tcgcggccag cagagcgctg
    23341 atgcggtgcg ggtctgcgcc ggctgtccgg gaggcgtgga gccggccggc ggtgtgcagg
    23401 gtgacgccga caccggcgtc ctggagggcg gccgccaggt cccgcaggcg ggggaggagc
    23461 gcggccggtt cggtggtgcg gtcgaccagt ctgcggagca gatcggcgcg ttcggccacg
    23521 agcaggggtt ccgacgccag ttgcccggcg agcgccgcga gcatctcggg ccgctcggac
    23581 tggttcgagc tcggggtcac cagggtgcgg agccgctgca gggccggcag gtcgcggtcc
    23641 ggcagggcgt cgcagccgcc gtcgggcgtg tgcatcgcgg cgagcagctt cgccaccgcg
    23701 ccgtggagca cgctgcccgg atccgcaccg cccacggggt gcggaagttc cgatgcggcc
    23761 acctcgcgca ggacccaggc cgcgtatcgc cagtgggccc ggttgcccag atcgcagacc
    23821 gttccggaga gccggccggc gacctcgggg gcgtagcggg accacgcgcc cagggcgtgc
    23881 agtgtgccgt aggtcgcgta gccgtcgacg gccgccagac acgcgtcgta cgcggcgccg
    23941 accacggcgg cgtaccccgt gcgatggctg tgggccagct cccagggagt gacccgtagg
    24001 agggcgtcga gcacgggcgg ggcgtcgtcg cgtgcggcgt cgtggaggac gcgccaggcg
    24061 gcgggcacgt cgagcagcgg cggcagggcg cggacgacgg cggcccgtac gtcagggtgg
    24121 cggtcggggg cgtcgaaggc ccgtgccagc agggacaccg cttgtcgcgg cggcaggaaa
    24181 cgggccgcga gccgtaccgc ctccttgcgg gaggtcacct tcgccacccg ctccccggcc
    24241 agcaactcgc ccagctccag ggcgagttcg gaaggggtgg cgaagcgggc ggcgcgggtc
    24301 gccgcgtaga ccgcgacccg tgcccggtca ctgccggcct gctccagcag caccggcagg
    24361 acctcgtggg gccggtcggt ccagggcagc gcgccgagcg ccgcctcggc gacgaccacg
    24421 tccccgtcgt cggcgtgccg catcgccagc gcacgtccca ggtcggggat ccgcgcggcg
    24481 gcccggaccg cggcggcgcg ctcgtccagc ggcagggagc ggtccgcggc ggcctgcccg
    24541 gcgagccgtg ccgcggcccg ctgctggcgg ggcagccagc ggtcgctgtc gccgagatcc
    24601 ggcagcgggc gccgggcacc gcgcaccagg aagcggccgc agggcggggc gtcgtcgagc
    24661 agtgcgtcga gcaggtccgt acgccgtcgg gacaggaccc gtcgtacggg tgggaggacg
    24721 accgccgagg gttcgagcgc gacgatccgg gccacccgct cgtcgcgggt ggccggtgcg
    24781 gcaagccacc gctccgcggc cgccgcgaac gtctcgtcgt cgccccgttc cagggcc
//
