LOCUS       NZ_AP026073            22682 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 chromosome.
ACCESSION   NZ_AP026073
VERSION     NZ_AP026073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8253039)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7844572
            Orig. end                         :: 7867254
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026073.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22682
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="26"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22682
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22682
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12682](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12682
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    197..206
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.55"
                     /tool="antismash"
     misc_feature    197..211
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.24"
                     /tool="antismash"
     misc_feature    259..274
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    complement(359..372)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.13"
                     /tool="antismash"
     misc_feature    complement(359..375)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.87"
                     /tool="antismash"
     misc_feature    372..385
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.73"
                     /tool="antismash"
     misc_feature    374..390
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.5"
                     /tool="antismash"
     misc_feature    complement(374..390)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     misc_feature    complement(376..391)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            437..1678
                     /locus_tag="HEK616_RS34880"
                     /old_locus_tag="HEK616_71040"
     CDS             437..1678
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981569.1"
                     /locus_tag="HEK616_RS34880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71040"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_261956821.1"
                     /sec_met_domain="Aldedh (E-value: 1.9e-23, bitscore: 81.5,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSAPAWPTVAAEPEDRVDGRRAAAVHRVRDFLVDNADTVHALLC
                     EISTHRAARYEIESTVATLDGALDEVATHRPGRVPRLAAFMPSNVILYSYALYLLVPAL
                     YTERLVFRPSSRVKDQMRRLHALLAEQHRLPITLTTASQREFLQDHVSPADVVVFTGAY
                     ANAEQIRARLTPGQLFLFLGSGVNPFVVAPGADVERAARDALAIRVLNTGQDCLGPDLF
                     TVHASLLDPFVDALVSELKGLRYGPYTDPDADFGPIFYESALEDGAQFLARNRGGIVHG
                     GHVDFRARRLDPAVVVGDEVTPRTHVPEFFAPIFNVASYRDEEALAATLTTGTFTERAL
                     GSSVYGHAPALVEALRRRTTVTLDTTLLSIDDGNAPFGGYGRMANYISDGRELRAEPVL
                     ISKAVAAHRPGGGR"
     gene            1675..3399
                     /locus_tag="HEK616_RS34885"
                     /old_locus_tag="HEK616_71050"
     CDS             1675..3399
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981568.1"
                     /locus_tag="HEK616_RS34885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71050"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_261956822.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7.2e-46, bitscore:
                     154.6, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.1e-17, bitscore:
                     61.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRHPAAHPSAWAAIADHLHHLGTTAVFGLPGDDMAPLGALEDSD
                     VHVVLCRDQRNAVFMATGYALASGRPGVCVIGKGPAVTNALTGLLEARSAAVPLILIAD
                     GTRLDRVGTGAFQELDQLAAVRPYVKWAVRVDHAERLPAALEKAAALAVNGTPGPVYVE
                     LAEQIAGEPVPRTGPWRPAVPQRPAPDPAALAATAARITAARRPLLLVGGGARHRNADR
                     RIERFAERLGAGIFTTASGRGTVAEDHPLHCGVSGLYTVGPVDALWREADLVVALGSRL
                     EETATFGWPEGADQLPVVQAVLGEESLVLDRPGAYVLADVAATVDGWAGLLDGHRPDGA
                     WAERVRSVRAALAQRAADRAEEAGKRAPDGTVPVARVLADLERAVPAGRVLVQENGLQD
                     MWSYFFPHYALGAGGGSVVPSEQTPLGFGAAAAVGVRLAEPAGRPVVAVVGDGAFHLFR
                     AELPTVADAGAAVLYVVLDNGGYGWLQSNLDRVSGPDSRFAFTRPRPTGTDGLTGAYGL
                     GHRRVTDPDRLSDALAAAWREVAAGTTSVVEVAVALADTPPGMTGAAGDFPERAEEE"
     gene            complement(3589..4431)
                     /locus_tag="HEK616_RS34890"
                     /old_locus_tag="HEK616_71060"
     CDS             complement(3589..4431)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511815.1"
                     /locus_tag="HEK616_RS34890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71060"
                     /product="ABC transporter permease"
                     /protein_id="WP_261956823.1"
                     /transl_table=11
                     /translation="MTTLQAAPRPEAPAPLRDEGRIGLRATARHTGALVRRNLLRIRQN
                     PESMIDALLMPIVLTLLFVYVFGGVIGRGGSRAQYTAFLVPGLMVILGMTIAMAVGTGV
                     NDDFRTGVMDRFRTMPIARSSILVAKVVVETGRMLVAITVLLIVAALLGFDFSGRWPGI
                     AAAIGLTTLFGTSLIWIFMLLGLTLRTAQAIQGLSVIVLTPLQFASSIFVSPTTMPDWL
                     AAFTRINPLTHMADAARGLTLGEGPVAGPVLWTVVWSVGLTALTAPLAVAKFRRKTMN"
     gene            complement(4446..5114)
                     /locus_tag="HEK616_RS34895"
                     /old_locus_tag="HEK616_71070"
     CDS             complement(4446..5114)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003954840.1"
                     /locus_tag="HEK616_RS34895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71070"
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_261956824.1"
                     /transl_table=11
                     /translation="MTQPQRPDLTKDVAPASASPGLSGSARSVLASDAEREAMVERLRE
                     ATAEGRLTLEELAERSEAAYLARTREELASVGEDLPHVTAPATAGSGQRSFRALFGDLV
                     HHSPALDHGIEATAVLGDLTLDLCSSPAPPTGELTIEAKALVGDVHLLLPEGVRVEMNC
                     SKVFGDLRDLTRAHSGPESVTPLIRVTGSAVFGDIIVAHPSSDRRSYWQKWLDERRGRA
                     "
     misc_feature    complement(4959..4961)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5491..5506
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     misc_feature    5502..5517
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.46"
                     /tool="antismash"
     gene            5600..6904
                     /locus_tag="HEK616_RS34900"
                     /old_locus_tag="HEK616_71080"
     CDS             5600..6904
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.5"
                     /locus_tag="HEK616_RS34900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71080"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_261956825.1"
                     /transl_table=11
                     /translation="MPELADTGRRIKELRVSAGMTQHDLAGSDMSSSYISLVERGKRIP
                     SGRALKILAARLGVGVDEISSSPQPAESPGLARRLDLVGRLVAARRQWEGGDAEGALSE
                     FRALASMEPAGRQDDVFTEAQLAIAEILGSLGRADEGADVLLRMLDALAPAPYAEARLR
                     ALIALADLLESAGRVQDGLRYALTGYLECTDRRVAQGPGTGPATGPGTGFHLLLVLDVL
                     TRCAYWSGCPDWAPEPEHPRPPADGVLPGPRATIDLHRALALRDRGERERAAELLGECA
                     RRVTPAAGFPLWEKVNGQYALLLLHRGDSAAARSIVERGLVVASVAQEPEFPLWLTTAD
                     AVCAEASGDRDRLAALGEELAALPETGRSHEKAAALQEIAAACERVGDRERAAGHYRQS
                     ADLFRRAQAYRHAERARERLVRLAESPARQPQEQL"
     gene            complement(7344..7523)
                     /locus_tag="HEK616_RS34905"
                     /old_locus_tag="HEK616_71090"
     CDS             complement(7344..7523)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538451.1"
                     /locus_tag="HEK616_RS34905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71090"
                     /product="DUF5708 family protein"
                     /protein_id="WP_261956826.1"
                     /transl_table=11
                     /translation="MKGIAVGIVLAVIGLVLWLTTKEVETPIVSLHKAGLILAIVGGAE
                     ALFALLGLGKKANK"
     gene            7974..9239
                     /locus_tag="HEK616_RS34910"
                     /old_locus_tag="HEK616_71100"
     CDS             7974..9239
                     /EC_number="2.3.1.-"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (9-419). E-value:
                     2.2e-57. Score: 186.8. Matches aSDomain:
                     nrpspksdomains_HEK616_RS34910_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578549.1"
                     /locus_tag="HEK616_RS34910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71100"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_261956827.1"
                     /sec_met_domain="t2fas (E-value: 5.1e-142, bitscore: 472.2,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.1e-51, bitscore:
                     173.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELRTDRRRVVVTGCGVVSPVGNTTEDFWTALLAGRSGVTALTRF
                     DTSGLPVRIGGDLTGFDPAGSGFLTPQEVRRTDLFTQYAVVAAGQAMRAAGLEPRADVD
                     PYRFAAVIGSGYGAAHAIQQQYDVLKNQGARRVSPYHSVLTAIDHPAGLLSIKYGISGP
                     SCAVSAACATGAVALGEAAELIRHGRADVVLAGGTDDSLTAADLAGTANARALSRRNDD
                     PEGASRPFDRDRDGFVMAVGATVLTLEEAGHAERRGATILAEVAGYAATTDAHHATAPD
                     PTGAGAVRAMRGALADAGLTPGDVGQVSAHGTGTVLNDRIEAAALREVLGPDQLRRTPV
                     TAVKSMTGHMLGASGAAEAAAAVLSLRDRRIPPIRNCDHPEDDDLDLVVKGARDWDGDA
                     VLSNSFGFGGHNAVLVLTRYRT"
     misc_feature    7980..7982
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        8001..9230
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: False"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS34910_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.20E-57"
                     /label="HEK616_RS34910_PKS_KS.1"
                     /locus_tag="HEK616_RS34910"
                     /protein_end="419"
                     /protein_start="9"
                     /score="186.8"
                     /tool="antismash"
                     /translation="VVVTGCGVVSPVGNTTEDFWTALLAGRSGVTALTRFDTSGLPVRI
                     GGDLTGFDPAGSGFLTPQEVRRTDLFTQYAVVAAGQAMRAAGLEPRADVDPYRFAAVIG
                     SGYGAAHAIQQQYDVLKNQGARRVSPYHSVLTAIDHPAGLLSIKYGISGPSCAVSAACA
                     TGAVALGEAAELIRHGRADVVLAGGTDDSLTAADLAGTANARALSRRNDDPEGASRPFD
                     RDRDGFVMAVGATVLTLEEAGHAERRGATILAEVAGYAATTDAHHATAPDPTGAGAVRA
                     MRGALADAGLTPGDVGQVSAHGTGTVLNDRIEAAALREVLGPDQLRRTPVTAVKSMTGH
                     MLGASGAAEAAAAVLSLRDRRIPPIRNCDHPEDDDLDLVVKGARDWDGDAVLSNSFGFG
                     GHNAVLVLTRY"
     CDS_motif       8457..8504
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEK616_RS34910_0001"
                     /evalue="3.80E-02"
                     /label="PKSI-KS_m3"
                     /locus_tag="HEK616_RS34910"
                     /protein_end="177"
                     /protein_start="161"
                     /score="7.1"
                     /tool="antismash"
                     /translation="GPSCAVSAACATGAVA"
     gene            9303..10004
                     /locus_tag="HEK616_RS34915"
                     /old_locus_tag="HEK616_71110"
     CDS             9303..10004
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="HEK616_RS34915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71110"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_261956828.1"
                     /transl_table=11
                     /translation="MQGRLVTLEWPGDDDWAAIASWLRPGSPAAVLSGDWELLGAAEVE
                     QANRSGRVHHLVIRTKDGTRIGTVSYQRSGRIGGYTVGGAIGSPELWRRGYGAEAVVLL
                     VDYLFHQLDAHRVQVTTAGYNKGIIRLMTKTPFVVEGILRDHCYLDGEYHDAIVWGLLR
                     DEHYASLKPSEDNRVLAVGLEDFVSEDDKVQARAVLTEHLATADRTALTPYLEPDVTAP
                     GKIVPAERGAA"
     gene            10001..12682
                     /gene="lanKC"
                     /locus_tag="HEK616_RS34920"
                     /old_locus_tag="HEK616_71120"
     CDS             10001..12682
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="HEK616_RS34920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71120"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_261956829.1"
                     /sec_met_domain="micKC (E-value: 5.5e-230, bitscore: 764.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.2e-12, bitscore:
                     46.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDGAESFALADRTFFDWPGNWDLEATRFPAPPLPDGWSREDNEA
                     WTICRPPEDRLPDQGWKIHVSASPDDAPRTLADVADYCARYGIAFKYLKSANVQRALSR
                     KYAQRSSAGKLLTVYPADEAELARTLEGLDAIVGGRPGPYVLTDLRFRQGPLYVRYGGF
                     RTHYMEDADGELVPAFRRPDGTPEPDRRTPVFHTPDWVTVPDILKDSLAARQAVDDFPY
                     RITGALHFSHGGGVYRAEPAGEQALGAGQHSVVLKEGRPYSGTDGVGRDAVARLAHEHR
                     ILTKLAGLPGIPRTFGTFQAGEHLFLVLEDIEGQDFQSWLAGLYPLTVPEPDEAAVAAH
                     RDRALALFGRIEELIASVHDRGVRIGDLHPGNFIIQPGDVPVLLDFEVADAIDLATPSS
                     LGAPGFHRADATGADGDHYALAAIALWLFLPLAALGGLAPDKASALLDTATRRFGLPGH
                     LVSRLAPQLAPNDNTTSPLRSVPEAFPPSDILASIDRGLRDSATPHRTDRLHPGDFAQF
                     AEGGAGFGHGAAGVLWARHTALGERDEEGAAWLRAAVDRVTAERIGFYDGLHGIAYVLA
                     ELGDREGALRALDRAADRLPVRHCPSLYRGLSGVGLNLLHFADALDDGALRQQALDLAD
                     RVTARLAAARTEPVERTRRRGSTHAGGLMYGWSGPALFLLRAHRATGDPALLDEAVRAV
                     HRDLDRCSPGPQDTLQVDEGFRLLPYLDNGSAGIALVAAELLRHRDDARLREALPGLLR
                     ACSSDFVIESGLWGGRAGLIGTLATLRAQAPWPPETAERYLRRHLTNLHQHAMTLNGAT
                     VFPCDGRARISMDVATGGAGVLLALSAAERGTPLLPFLPDPRSAAAGQPAVPERARGAH
                     GTATPTVPTGPAGTADNGREVS"
     gene            12692..12769
                     /locus_tag="HEK616_RS42055"
     CDS             12692..12769
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="HEK616_RS42055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_410011375.1"
                     /transl_table=11
                     /translation="MDLQGLEVPGERDAQALGSTVSTGC"
     misc_feature    complement(13044..13059)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            13057..13134
                     /locus_tag="HEK616_RS42060"
     CDS             13057..13134
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="HEK616_RS42060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_410011375.1"
                     /transl_table=11
                     /translation="MDLQGLEVPGERDAQALGSTVSTGC"
     gene            13223..15049
                     /locus_tag="HEK616_RS34925"
                     /old_locus_tag="HEK616_71140"
     CDS             13223..15049
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024846.5"
                     /locus_tag="HEK616_RS34925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71140"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_261956830.1"
                     /transl_table=11
                     /translation="MNDRTEPAARSLCIIGCGPRGTSLVERILANVPALYGDRPLDLHL
                     VDPYPPGAGRTWRTDQPGLLWMNSAAEQVTLYPDPSVSCAGPPRPGPTTAEWLTGPLHD
                     GAYAARRDQGRYLRHFFETVTAGRPSSVRLYVHRARAIDLRRTSVDGAAPATRQQVVLD
                     SAEPPFLADRVVLAQGHPDVRTEPAPAGLTRIGPGPADPAALDAVPPGAPVVVRGLGLV
                     FIDCLALLTEGRGGRFDRTPDGRLRYLPSGREPRLYAGSRRGVPLPPKPARAAVPSRPA
                     APRFATADACRARLSRPGATFGRDVWPLVLAELGWCHYRALFAEQPARARMTWDDFDAQ
                     YALLLTDADRLAKLAREAVPDPADRLDLDRLSAPLAGRRFADADGLQRWLRAHLAEVHH
                     RRTGPARAVTTALVDGLQRTGAVIEDLWRSGDLAGDQLADALARFSLGTYLSSGPPPLR
                     AEQLLALAEAGVVVFVGPEMRVEITTPATDGTGPVFRATSPAVPGVAHDAAVLLDARLS
                     APAPDRFADPLLRALLSRGELTEAHTEDGTPTGELRLSGPDLHPVDAHGTTHHDRVIAG
                     PAQFPRPGTDAIFFRQNDGVARSLLARLDPPT"
     gene            complement(15298..16443)
                     /locus_tag="HEK616_RS34930"
                     /old_locus_tag="HEK616_71150"
     CDS             complement(15298..16443)
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091409.1"
                     /locus_tag="HEK616_RS34930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71150"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_261956831.1"
                     /sec_met_domain="DAO (E-value: 8.9e-07, bitscore: 27.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTPRIAIIGAGPGGLVCARVLQQHGLPVTVFERESDPRSRSQG
                     GTLDIHEDTGQVALRAAGLFDRFRALSRPEGQQWRLYDRHAALIRHDRAGEDDLSKPEI
                     DRGQLRALLLDSLAPGTVRWGHGAEAVTPLPDGTVRLHHHDRTVGDFDLVIGADGAWSR
                     VRPALSDAQPSYAGVTMVEIHFDDVDRRHPGIARLVGSGTMSAKAGRRSLVLQRNSNGH
                     VRGYVTFRGPQDWHAGLDLADTEAVRARLLAQYQGWDESLLAILRDNEGAFINRPMFVL
                     PVPHTWQRVPGITLLGDAAHLMPPVGVGANLALLDGAELAQAVIDHPTVDQALDAYESV
                     MLPRAADHAKTAQQMLTSLMPDTDSDAAIFPDTQWPATPAR"
     misc_feature    complement(16437..16451)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.44"
                     /tool="antismash"
     misc_feature    16448..16461
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.68"
                     /tool="antismash"
     misc_feature    complement(16501..16517)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            16583..17188
                     /locus_tag="HEK616_RS34935"
                     /old_locus_tag="HEK616_71160"
     CDS             16583..17188
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091408.1"
                     /locus_tag="HEK616_RS34935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71160"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_261956832.1"
                     /transl_table=11
                     /translation="MAETTTGRRERKKAQTRQALADAALRLFTERGYDNVGVRDVAEAA
                     DVSLSTLFKHFPSKEALVFDLDADVESALVAAVRDRVPGQPVLHALRDHLVRTRTALRA
                     DDPVFVLVESTPALRDAARRMWSRHEKALAATLADATGLPPDDLAITGLARFALEAPTL
                     ARTSPDPAQAIRDLFALLEHGWATTPLARGEDHPGEDG"
     gene            complement(17201..17851)
                     /locus_tag="HEK616_RS34940"
                     /old_locus_tag="HEK616_71170"
     CDS             complement(17201..17851)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845398.1"
                     /locus_tag="HEK616_RS34940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71170"
                     /product="response regulator"
                     /protein_id="WP_261957539.1"
                     /transl_table=11
                     /translation="MRVLVADDQAAVRSGLVLVLQTDPGITVVGEAGDGEAAVRMADEL
                     RPDVVLMDIQMPLLNGVAATRLIVERQLAEVLVLTTFDIDEYIFGALRAGAGGFILKNA
                     EPTVLVGAVREVAHGEGFLTPAIARRLITEFAHRPPSARPTLPQGTTQALDTLTKRERE
                     VLACIARGLPNSAIAASLNLAEGTVKTHTSRILSKLNLRSRVQAAILAQQQGI"
     misc_feature    complement(17945..17961)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.18"
                     /tool="antismash"
     gene            complement(18029..19264)
                     /locus_tag="HEK616_RS34945"
                     /old_locus_tag="HEK616_71180"
     CDS             complement(18029..19264)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.5"
                     /locus_tag="HEK616_RS34945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71180"
                     /product="sensor histidine kinase"
                     /protein_id="WP_261956833.1"
                     /transl_table=11
                     /translation="MGFFAACLILYVLGGSRVMGDIPVWQAVLPVVVLCTASAFRSTLP
                     TAAVSVGTVTVLVEMTSSGGLGPVLVYTDLLYAAALYGAPWLCRVLQFGTVAVTIATTI
                     TLIAISDRSEGVTTGVIVAMLLISPVWTGILIRNHKERADSERERAAQINRLAELDRKT
                     ILQTERTRMARELHDLVANHLSAIAIHSSAVLSLTEARRDRNGEAGCAGSGESAGSGES
                     AGSGEDDPVLRALAVIRENSVQGLAEMRRMVVLLRSDRGVDDDWDRPQLNALGALVEQA
                     RPAADAAALTLHTEFPETFPEVSSVIEVTAYRIVQEALTNVLKHASSGRVRIRCEAGTE
                     RLTISVDSPLALPDARTRQRPVAALTTGAGAGLTGMSERAALVGGIFDAGPDRTAPGRW
                     RVRAVLPLTQNT"
     gene            19591..20400
                     /locus_tag="HEK616_RS34950"
                     /old_locus_tag="HEK616_71190"
     CDS             19591..20400
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS34950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_71190"
                     /product="hypothetical protein"
                     /protein_id="WP_261956834.1"
                     /transl_table=11
                     /translation="METNAALLELCPGYLDQDVPGRPHHPARPRLAPLAPVPIFIVPIG
                     EDGPSPSSPSALVPSPSLSYLPSAPSSAGSPSSLRGSGSALSPDSCLGLNGHSAATLDD
                     ASRRWLLSGLPARVSTAMAEASYWELYGTRGLLVVACGEDARQMGFSVESVRRGSPPPH
                     TPCEVLTARELRAADRFPETERERMITRFWVRKDAAMQAAGGGLSSAPERIEAGFPADH
                     GTVTVPGPYGCDVPVSVRNFTFSPSYEFAVATPEPLPLAPSFAYSVS"
     misc_feature    19593..19604
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 21.4"
                     /tool="antismash"
     gene            20681..21406
                     /locus_tag="HEK616_RS34955"
                     /old_locus_tag="HEK616_71200"
     CDS             20681..21406
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092320.1"
                     /locus_tag="HEK616_RS34955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71200"
                     /product="transglycosylase family protein"
                     /protein_id="WP_261956835.1"
                     /transl_table=11
                     /translation="MPSPLAKRSAHTLLSVLLAVLAVVGLAAHRAAAAAPSGPVPDWER
                     IADCESNGRWHINTGNGYHGGLQIDPATWRAYGGRRYAPRADLATRSEQIAVGRRIVRD
                     RGLSAWPRCAYTQQSPRASSPGQQAPPAAAPDQPAPRTSAPPPQTARTTDPAQQPPADD
                     DQLAPPAPSPGSHPAVRAAAYHHPNHATYVVRTGDCLSVIAERNQVPGGTQALYELNKH
                     KLPHGPDHIFPGQRLRLRA"
     gene            21784..22170
                     /locus_tag="HEK616_RS34960"
                     /old_locus_tag="HEK616_71210"
     CDS             21784..22170
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604562.1"
                     /locus_tag="HEK616_RS34960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71210"
                     /product="hypothetical protein"
                     /protein_id="WP_261956836.1"
                     /transl_table=11
                     /translation="MKKRTRVSIVIAGACGMLLAAGGVSPALAWDGGYGGFGTGGNVID
                     SDVWASFHSIIRCSPRARVCVNGPVNSGNTKNSQNVHMSGNNSDSGSPTNSNGNTNVDS
                     GGTTGAENHTGNDIQHNGPGSTRI"
     gene            complement(22242..22655)
                     /locus_tag="HEK616_RS34965"
                     /old_locus_tag="HEK616_71220"
     CDS             complement(22242..22655)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570975.1"
                     /locus_tag="HEK616_RS34965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_71220"
                     /product="hypothetical protein"
                     /protein_id="WP_261956837.1"
                     /transl_table=11
                     /translation="MRRLAQAGTVIGACGLVLLSTNTAQAVTIPGESLLSAAVGADLGT
                     ITGMVSGVMCNNRLADFHYKSPRINSPSPQPCINGPVHSGNSVHSGNFINHGNPNHSGN
                     FANTNGSTNSSNLVSGAQQGSGNTVQKILKLHP"
ORIGIN
        1 cgcgcggcgg acctcccgca ctcgcttccc gaaagcaggc tgctcaatca ccaaggaatc
       61 gctcgcagtt gagttgggcg gacggacagt gacggtgtac ggacggcgcc ggacggccga
      121 acgtgatgac ggggagtcta ctcaccggac gcccgctcgg gggcctctgt ggacgacctt
      181 cgttccggcg aggagtcatt ttttgtcact tacggaggtc ggtattcctc ttgctcgcgc
      241 gacgggcatc gcgacagttc ggaggcgtgt tcgggccggt agggcgggga tcggcaggtc
      301 cgtggcgggg gttgcggacg ggacgcggcg agaggtactt gtcacaacgg ccggtcgagt
      361 gtaatgactt tacttgacaa taaatgacaa ttggctgacg ctgaccctcc atggactacg
      421 ccccgaggag ggacatatga gctccgctcc cgcatggccg accgtggccg ccgagccgga
      481 ggaccgtgtc gacggccgac gcgcggcggc cgtgcaccgg gtccgggact ttctggtgga
      541 caacgccgac accgtgcacg cgctgctgtg cgagatctcc acccaccgcg ccgcgcgcta
      601 cgagatcgag tccaccgtcg ccaccctcga cggggccctg gacgaggtgg ccacccaccg
      661 gcccggccgc gtcccccggc tggccgcctt catgccgtcg aacgtcatcc tctactccta
      721 cgccctctac ctcctggtcc ccgccctgta cacggagcgg ctggtcttcc gcccctccag
      781 ccgcgtcaag gaccagatgc gccggctgca cgcgctgctc gccgagcagc accgcctgcc
      841 catcaccctc accaccgcca gccagcgcga gttcctccag gaccacgtca gcccggcgga
      901 cgtcgtcgtc ttcaccggcg cctacgccaa cgccgagcag atccgcgccc ggctcacccc
      961 cggccagctg ttcctcttcc tcggctccgg cgtcaacccg ttcgtggtcg cccccggcgc
     1021 cgacgtcgaa cgggccgccc gcgacgccct cgccatccgc gtcctcaaca ccggccagga
     1081 ctgcctgggc ccggacctct tcaccgtcca cgcctcgctg ctcgacccgt tcgtggacgc
     1141 cctggtcagc gagttgaagg ggctgcgcta cgggccgtac accgacccgg acgccgactt
     1201 cgggccgatc ttctacgaga gcgcgctgga ggacggcgcg cagttcctcg cccgcaaccg
     1261 cggcggcatc gtgcacggcg ggcacgtcga cttccgggcc cgccgcctcg accccgccgt
     1321 cgtcgtcggc gacgaggtca ccccgcgcac ccacgtgccg gagttcttcg ccccgatctt
     1381 caacgtcgcc tcctaccgcg acgaggaagc gctcgccgcg accctcacca ccggcacctt
     1441 caccgaacgc gccctgggct ccagcgtcta cggccacgcc cccgccctcg tcgaggcgct
     1501 ccgccggcgc accaccgtca ccctggacac caccctgctg tccatcgacg acggcaacgc
     1561 ccccttcggc ggctacggcc ggatggccaa ctacatatcc gacggccggg agttgcgcgc
     1621 cgagcccgtg ctgatctcca aggccgtcgc cgcccaccgt ccgggaggcg gccgatgagc
     1681 cggcaccccg cggcccaccc gtccgcctgg gcggcgatcg ccgaccacct ccaccacctg
     1741 ggcaccaccg cggtcttcgg gctgcccggt gacgacatgg cgccgctcgg cgcgctggag
     1801 gactccgacg tccacgtggt gctctgccgc gaccagcgca acgccgtctt catggcgacc
     1861 ggttacgcgc tggcctccgg ccgccccggg gtctgcgtga tcggcaaggg cccggcggtg
     1921 accaacgcgc tcaccggcct gctggaggcg cgctccgccg cggtaccgct gatcctgatc
     1981 gccgacggca cccggctgga ccgggtcggc accggcgcct tccaggagct ggaccagctg
     2041 gccgcggtcc gcccgtacgt gaagtgggcg gtccgcgtcg accacgccga gcggctgccg
     2101 gccgccctgg agaaggccgc cgcgctcgcc gtcaacggca cgcccggacc ggtctacgtc
     2161 gaactcgccg agcagatcgc cggcgaaccc gtcccccgta ccgggccctg gcgcccggcc
     2221 gtgccccagc ggccggcccc cgaccccgcc gcgctggccg cgaccgcggc ccggatcacc
     2281 gccgcacgac ggccgttgct gctggtcggc gggggtgccc ggcaccgcaa cgcggaccgc
     2341 cggatcgagc ggttcgccga gcggctgggc gccgggatct tcaccaccgc ctccggccgc
     2401 ggcaccgtcg ccgaggacca cccgctgcac tgcggcgtca gcggcctcta caccgtcggg
     2461 ccggtggacg ccctgtggcg cgaggcggac ctggtcgtcg cgctgggcag ccgcctggag
     2521 gagacggcca ccttcggctg gccggagggt gcggaccaac tccccgtcgt ccaggccgtc
     2581 ctgggcgagg agagcctggt cctggaccgt ccgggggcgt acgtcctggc ggacgtggcg
     2641 gcgaccgtgg acggctgggc cgggctgctc gacgggcacc ggccggacgg ggcctgggcc
     2701 gagcgggtcc gctccgtacg ggccgcgctg gcgcagcgcg ccgcggaccg ggccgaggag
     2761 gccgggaaac gggcgccgga cggcaccgtc ccggtcgccc gggtgctggc cgacctggag
     2821 cgggccgtcc ccgccggccg ggtcctcgtc caggagaacg gcctgcagga catgtggtcg
     2881 tacttcttcc cgcactacgc gctcggtgcc ggcggcggtt ccgtcgtccc cagcgagcag
     2941 acgccgctgg gcttcggcgc ggcggccgcg gtcggcgtac ggctggccga gccggccggg
     3001 cggcccgtgg tcgcggtggt gggcgacggc gccttccacc tcttccgcgc cgagttgccg
     3061 acggtcgcgg acgccggcgc ggccgtcctc tacgtcgtcc tggacaacgg cggctacggc
     3121 tggctgcagt ccaacctcga ccgggtctcc ggcccggact cccgcttcgc cttcacccgc
     3181 ccccggccca ccggcaccga cggtctgacc ggcgcgtacg gcctgggcca ccgccgggtg
     3241 acggaccccg accggctgtc cgacgcgctg gccgcggcct ggcgcgaggt cgccgccggc
     3301 accacgtccg tcgtcgaggt ggcggtggcg ctggcggaca ccccaccggg gatgacgggc
     3361 gcggcgggcg acttcccgga gcgggcggag gaggagtagc cgggacccgg cccatggggg
     3421 gccgtgccgc cgtcggcggc acggcccccg cgtgcgtcgg ggcgtgcgtg ggccggcccc
     3481 ttccccggct cgggggtggc cgggggcggg gccggtccac gtcttcttcg tacggggagc
     3541 cacgccgaag gcgtgacggg gatgcgctcc cttgcgtacg gatcggtgtc agttcatggt
     3601 cttgcggcgg aacttggcga cggccagcgg ggcggtgagc gcggtcaggc ccaccgacca
     3661 caccaccgtc cagagcaccg ggccggccac cgggccctcc cccagagtga gtccacgggc
     3721 cgcgtcggcc atgtgggtca gggggttgat ccgggtgaag gcggccagcc agtccggcat
     3781 cgtcgtgggc gagacgaaga tcgaggaggc gaactgcagc ggggtcagca cgatcaccga
     3841 gagcccctgg atggcctgcg cggtgcgcag ggtcagcccg aggagcatga agatccagat
     3901 cagcgacgtg ccgaagagcg tggtcaggcc gatggccgcg gctataccgg gccagcggcc
     3961 ggagaagtcg aagccgagca gggcggcgac gatcagcagg accgtgatgg cgaccagcat
     4021 ccggcccgtc tccaccacga ccttggccac gaggatcgag gagcgggcga tcggcatcgt
     4081 gcggaagcgg tccatcacgc ccgtgcggaa gtcgtcgttg acgccggtgc cgacggccat
     4141 ggcgatggtc atgccgagga tgaccatcag gcccggcacc aggaaggcgg tgtactgggc
     4201 gcggctgccg ccgcggccga tcaccccgcc gaagacgtag acgaacagca gcgtcagcac
     4261 gatcggcatc agcagcgcgt cgatcatcga ctccgggttc tgccggatcc ggaggaggtt
     4321 gcggcggacc agcgcgccgg tgtgccgggc cgtggcccgc agcccgatcc ggccctcgtc
     4381 gcggaggggg gcgggcgcct cggggcgggg cgcggcctga agggtcgtca cggctgctcc
     4441 tccggtcagg cccggccgcg gcgttcgtcc agccacttct gccagtacga gcggcggtcg
     4501 ctgctggggt gggcgacgat gatgtcgccg aagacggcgg agccggtcac gcggatgagc
     4561 ggggtgacgg actcggggcc ggagtgcgcc cgggtcagat cgcggaggtc gccgaagacc
     4621 ttgctgcagt tcatctccac ccggacgccc tcggggagca gcagatgcac atcgccgacg
     4681 agcgccttgg cctcgatggt gagctcaccg gtcggcggtg cgggggagga gcacaggtcg
     4741 agggtgaggt caccgaggac cgcggtggcc tcgatgccgt ggtccagcgc ggggctgtgg
     4801 tggacgaggt caccgaagag ggcgcggaag gaacgctggc cggagccggc ggtggcgggg
     4861 gccgtgacat gggggaggtc ctcgcccacg gacgccaact cctcgcgcgt ccgggccaga
     4921 tacgccgcct cggagcgctc ggcgagctcc tcgagggtta accggccttc cgcggtggcc
     4981 tccctgagcc gctcgaccat ggcctcccgc tcggcgtccg acgccagcac cgagcgggcg
     5041 gatccggaga ggccggggga ggcggatgcg ggcgccacat ccttggtgag gtcgggacgt
     5101 tggggctggg tcatggaggg tgcctccgcg gggtccggcg gtggtggggc gtgtgcgtgc
     5161 tcatcgcacc acgtcggacc gggcgtggac atcggcgcgg ggtagtacat cgaaaggttg
     5221 acccgcggcc ccgggcacac agttcggcgt acgaggcggt cgcggcgtag gcggtgggcg
     5281 gggcgtaagc ggcgggcgtg gccacgggac gtggcggacg gggtccgccg ggggaggggc
     5341 cggccgcgcg tgacggttcc gggggattga cggggcggcg gacttccccg gcattggtgt
     5401 actcggcggc cggttttccg ctccggtagt cacccgggaa atgatctcgg tgaccaccgg
     5461 tgaagaccgg tgaaggaatc cgaatatcgg tcgacttctt cttgactgct tggtaaagta
     5521 cccagcactc attgtgactc ggcgttttga tccgaccggc cggagtcatc cactgttcga
     5581 aatccggagg gtttggcgaa tgcctgagct ggcggacacc gggcggcgaa tcaaagagct
     5641 tcgggtcagc gcgggaatga cgcagcacga ccttgccggg tccgatatgt cgtccagcta
     5701 catctcgctg gtcgagcgcg ggaagcgcat tcccagtggc cgggcgctca agatcctcgc
     5761 ggcccgcctc ggcgtcggcg tggacgaaat ctccagcagc ccccagccgg ccgaaagtcc
     5821 gggcctggcc cgccggctgg acctggtcgg acgattggtc gcggcccgcc ggcaatggga
     5881 gggcggcgac gccgagggag cgctctcaga attccgcgca ctggcctcga tggagccggc
     5941 cggcaggcag gacgacgtat ttaccgaggc gcagctcgcc attgccgaaa tattgggctc
     6001 gctcggtcgc gccgacgagg gcgccgacgt cctgctgcgg atgctggacg cgctcgcccc
     6061 cgcgccgtac gccgaggccc ggctgcgtgc cctgatcgcc ctcgccgacc tgctggaatc
     6121 ggccggccgg gtgcaggacg ggctgcgcta cgccctcacc ggctacctcg aatgcaccga
     6181 ccgccgcgtg gcccagggcc ccggcaccgg cccggccacc ggccccggca ccggcttcca
     6241 cctgctgctc gtcctcgacg tgctcacccg ctgcgcctac tggagcggct gcccggactg
     6301 ggcccccgag cccgagcacc cccgcccgcc ggccgacggc gtccttcccg ggccgcgcgc
     6361 caccatcgat ctgcaccggg cgctcgcgct gcgggaccgc ggcgagcggg agcgcgccgc
     6421 cgagctgctg ggcgagtgcg cgcgccgggt caccccggcc gccgggttcc ccttgtggga
     6481 gaaggtcaac ggccagtacg ccctgctgtt gctgcaccgc ggcgattcgg cggcggcgcg
     6541 cagcatcgtc gaacgcgggc tggtggtcgc ctcggtggcg caggaaccgg aattcccgct
     6601 ctggctcacc accgcggacg cggtctgcgc ggaggcctcc ggcgaccggg accggctggc
     6661 cgccctgggc gaggagctgg ccgcgctgcc cgagaccggc cgcagccatg agaaggccgc
     6721 cgcgctccag gagatcgcgg cggcgtgcga gcgggtgggg gaccgtgagc gggcggccgg
     6781 acactaccgg cagtccgccg acctgttccg gcgggcccag gcgtatcggc acgccgagcg
     6841 ggcccgtgag cggctcgtgc ggctcgccga aagcccggcc aggcagccgc aagagcagct
     6901 ctgaagcagc cctcgggcgg cgctgaagcc gctccgggat ggccctgaag ccgctccgag
     6961 gcggctccga agcgactcat gaagcggctc atgatgcggc tcctgaagcc gttccgacgc
     7021 gtgcgtgagc cgccggtcga agacgtccgg cgagcgcgcc ggcgggcctg ccgaggccgc
     7081 ccggcgaacg cgaaagcaaa cgcggcaatg gcagatgcgc ggccggcggc cggaaaagcc
     7141 ggcggacggc cgcatcggca tccatggtgg ttgagcacaa aatcaaggcc gcggtccgca
     7201 tatacgtggc cggtgaacgg gatttgcggt gcgaccggtc gcaaaagcgg gcgggcgacc
     7261 gccgggacgg aaagacgccg cggcggcgca atgggccctg gggcgctatg cccttatgtc
     7321 gttattgcgc gtaattgacg cattcattta ttagctttct ttcccaatcc gaggagcgcg
     7381 aacagtgcct ccgcgccgcc cacgatcgcc aggatgagcc ccgccttgtg cagggagacg
     7441 atcggcgtct cgacttcctt tgtggtcagc cacaggacca gcccgatgac cgccagaaca
     7501 atgcctaccg caataccctt catcggttcc cttgtctcct cgtcccggtg atggtcccgg
     7561 tgatggcgcc ccggccggcc ggcgcggggc ggtggtagtc accagcgtcc cgtcgcggcc
     7621 cggcctccgg atcgtccgca ggtaggcact ttccggcccg cggactgtca ctttctatgt
     7681 acgccgggcc ctaccagggg gctgtggggc gtgcgccccc ggagctcgcc caccgcgccc
     7741 gggccccctc cccgcctcct cgaaccgtcg ccatagtcaa ttttcctgac tctgtcagtc
     7801 atcgccttga gagcgtttcc gctggtgcga ggcctgatgc cccggagtga caggaaacct
     7861 cgactgacca cttctcccgc aacctgttga caagccgatg actcagctgt catgtttctg
     7921 gtcatgagga cgccccgagc gtgacaacgg ggcaggaaat caggaggcgt ttcatggagt
     7981 tacgcacgga tcggcggcgc gtcgtcgtca ccggctgcgg cgtggtgtcc cccgtgggaa
     8041 acaccaccga agacttctgg accgccctcc tcgccggccg cagcggcgtc accgcgctca
     8101 cccgcttcga cacctccggc ctcccggtcc gcatcggcgg cgacctcacc ggtttcgacc
     8161 cggccggctc cggcttcctc accccgcagg aggtccggcg caccgacctc ttcacgcagt
     8221 acgcggtggt cgccgccggc caggcgatgc gggccgccgg cctcgaaccc agggccgacg
     8281 tcgaccccta ccgcttcgcc gcggtgatcg gctccggcta cggcgccgcg cacgccatcc
     8341 agcagcagta cgacgtgctc aagaaccagg gcgcgcggcg ggtctccccg taccactcgg
     8401 tgctcaccgc catcgaccac ccggccggcc tgctgtccat caagtacggc atcagcggcc
     8461 cgagttgcgc ggtctccgcg gcctgcgcga ccggcgcggt ggccctcggc gaggcggccg
     8521 aactgatccg ccacggccgg gccgacgtgg tcctggccgg cggcacggac gactccctca
     8581 ccgccgccga tctggccggc accgccaacg cccgggcgct ctcccgccgc aacgacgacc
     8641 ccgaaggcgc cagccggccc ttcgaccggg accgcgacgg cttcgtgatg gccgtcggcg
     8701 ccaccgtcct gaccctggag gaggccggcc acgcggaacg ccgcggcgcg acgatcctcg
     8761 ccgaggtcgc cggttacgcc gccaccaccg acgcccacca cgccaccgcc cccgacccga
     8821 ccggtgccgg cgcggtccgc gcgatgcgcg gggcgctcgc cgacgcgggt ctgacccccg
     8881 gtgacgtcgg gcaggtcagc gcccacggca ccggcaccgt cctcaacgac cgcatcgagg
     8941 cggccgcgct gcgcgaggtg ctcggccccg accagctgcg ccgcacaccg gtcaccgcgg
     9001 tcaagagcat gaccgggcac atgctcggcg cgtccggggc cgccgaggcc gccgccgcgg
     9061 tgctctcgct gcgggaccgc aggatcccgc cgatccgcaa ctgcgaccac cccgaggacg
     9121 acgacctcga cctggtcgtg aagggtgccc gcgactggga cggcgacgcg gtgctgagca
     9181 attcgttcgg cttcggcggc cacaacgccg tcctcgtcct gacgcgctac cgcacatgac
     9241 ccgcacgcgg cccgagagcc gcacccgctg actcacgaga ccacagagga gggacacgca
     9301 ccatgcaggg acgactggtg accttggaat ggcccggcga cgacgactgg gccgcgatcg
     9361 cctcctggct gcgccccggc tcgcccgcgg ccgtgctcag cggtgactgg gagctgctgg
     9421 gcgccgccga ggtcgagcag gccaaccgct ccggccgggt ccaccacctg gtgatccgca
     9481 ccaaggacgg cacccgcatc ggcaccgtca gctaccagcg gtcgggccgg atcggcggct
     9541 acaccgtcgg cggcgcgatc ggctcgcccg aactgtggcg ccgcggctac ggcgcggagg
     9601 ccgtcgtcct cctcgtcgac tacctcttcc accagctcga cgcccaccgg gtgcaggtca
     9661 ccaccgccgg ctacaacaag ggcatcatcc ggctgatgac caagaccccg ttcgtggtcg
     9721 agggcatcct gcgggaccac tgttacctcg acggcgagta ccacgacgcg atcgtgtggg
     9781 gcctgctgcg cgacgagcac tacgcctcgc tcaagcccag cgaggacaac cgcgtactgg
     9841 ccgtcgggct ggaggacttc gtgtccgagg acgacaaggt gcaggccagg gcggtgctca
     9901 ccgagcacct cgccacggcc gaccggaccg cgctcacgcc ctacctggaa ccggacgtca
     9961 ccgcccccgg aaagatcgtc ccggccgagc gaggtgccgc atgagagacg gcgccgagag
    10021 ctttgccctg gccgaccgca ccttcttcga ctggcccggc aactgggacc tggaggccac
    10081 ccgcttcccc gccccgccgc tgcccgacgg ctggagccgc gaggacaacg aggcctggac
    10141 catctgccgc ccgcccgagg accggctccc cgaccagggc tggaagatcc acgtcagcgc
    10201 gtcccccgac gacgcccccc gcaccctcgc cgacgtcgcc gactactgcg cccggtacgg
    10261 catcgccttc aagtacctca agagcgccaa cgtccagcgc gccctgagcc gcaagtacgc
    10321 ccagcgctcc tccgccggca agctgctgac cgtctacccc gcggacgagg ccgaactggc
    10381 ccgcaccctc gaaggactgg acgcgatcgt cggcggccgc cccggcccgt acgtcctgac
    10441 cgacctgcgc ttccgtcagg gcccgctcta cgtccgctac ggcggattcc gcacccacta
    10501 catggaggac gccgacggcg agctggtccc ggccttccgg cgccccgacg ggacgcccga
    10561 accggaccgc cgcaccccgg tcttccacac ccccgactgg gtcaccgtcc ccgacatcct
    10621 caaggactcg ctggccgccc ggcaggccgt ggacgacttc ccgtaccgga tcaccggcgc
    10681 gctgcacttc tcgcacggcg gcggcgtcta ccgcgccgaa ccggccggtg aacaggccct
    10741 cggcgccgga cagcacagcg tcgtcctcaa ggagggccgg ccgtactccg gcaccgacgg
    10801 cgtcggccgg gacgcggtcg cccggctcgc ccacgagcac cggatcctga ccaagctggc
    10861 cggactgccc gggatccccc gcaccttcgg caccttccag gccggcgaac acctcttcct
    10921 ggtcctggag gacatcgagg ggcaggactt ccagtcctgg ctcgccgggc tctacccgct
    10981 gaccgtcccc gaacccgacg aggcggcggt ggccgcccac cgggaccgcg ccctcgccct
    11041 gttcggccgg atcgaggaac tgatcgcctc ggtgcacgac cgcggggtgc gcatcggcga
    11101 cctgcacccg ggcaacttca tcatccagcc cggcgacgtc cccgtcctcc tggacttcga
    11161 ggtggccgac gcgatcgacc tggccacccc cagcagcctc ggcgcccccg gcttccaccg
    11221 ggccgacgcc accggcgcgg acggcgacca ctacgcactg gccgcgatcg ccctgtggtt
    11281 gttcctgccg ctcgccgcgc tcggcggcct ggcccccgac aaggcgtcgg ccctgctcga
    11341 caccgcgacc cgccggttcg gcctccccgg ccacctggtg tcccggctcg ccccccagct
    11401 cgccccgaac gacaacacca cgtcgccgct gcgcagcgtg ccggaggcgt tcccaccctc
    11461 cgacatcctg gcctcgatcg accgcggcct gcgcgacagc gccaccccgc accgcaccga
    11521 ccggctccac cccggcgact tcgcgcagtt cgccgagggc ggcgcgggct tcggacacgg
    11581 cgccgccggc gtcctgtggg cccgccacac cgccctaggg gaacgcgacg aggagggcgc
    11641 ggcctggctg cgcgccgccg tcgaccgggt caccgccgaa cgcatcggct tctacgacgg
    11701 cctgcacgga atcgcctacg tccttgcgga gttgggcgac cgcgaaggag ccctgcgggc
    11761 cctcgaccgg gccgccgacc ggctcccggt acgccactgc cccagcctct accgcggcct
    11821 gtccggcgtc ggcctgaacc tcctgcactt cgccgacgca ctggacgacg gcgccctgcg
    11881 gcagcaggcc ctcgacctgg ccgaccgcgt caccgcgcgg ctcgccgcgg cccgcaccga
    11941 acccgtcgag cgcacccgcc ggcgcggctc cacccacgcc ggcggcctga tgtacggctg
    12001 gtcgggcccc gcgctcttcc tgctccgcgc ccaccgcgcg accggcgacc ccgccctgct
    12061 cgacgaggcg gtccgcgccg tccaccgcga cctcgaccgc tgcagccccg ggccgcagga
    12121 caccctccag gtcgacgagg ggttccggct gctgccctac ctcgacaacg gcagcgcggg
    12181 catcgccctc gtggcggccg aactcctccg ccaccgcgac gacgcccgcc tccgcgaggc
    12241 gctgccgggc ctgctccggg cctgctcctc cgacttcgtc atcgagtcgg gcctgtgggg
    12301 cggccgcgcc ggtctcatcg gcaccctcgc caccctgcgc gcgcaggccc cctggccacc
    12361 ggagaccgcc gagcggtatc tgcgccgcca tctgaccaac ctccaccagc acgccatgac
    12421 gctgaacggc gcaacggtct tcccctgtga cggccgggcc cggatctcca tggacgtggc
    12481 caccggcggg gccggcgtat tgctggcact ctccgccgcc gaacggggca ccccgctgct
    12541 gccgttcctc cctgacccgc ggtccgccgc ggccggtcaa ccggccgtcc cggagcgcgc
    12601 ccgtggtgcc cacggcaccg cgacccccac cgtcccgacc gggccggcgg gcactgcgga
    12661 caacggaagg gaggtgtcgt aaatgaccat catggatctt cagggtctgg aggtgccggg
    12721 cgagcgtgac gcccaggcgc tcggctccac cgtcagcacc ggctgctgaa tgacgccgac
    12781 gggccgtgca ccgtcattgc acggcccgtc gggtccaggt gtcccgcaac ggcacctgac
    12841 acgtcatcgg cgctgtccac cgctcctgct caccccccgg agggaggttc acatgtcggt
    12901 catggatctt cagggtctgg aggtgccggg cgagcgtgac gctcaggcgc tcggctccac
    12961 cctcagcggc ggctgctgac accgagttcg gtgtcgtcct acgcactcta cgcatccgca
    13021 acggacaacg gaagggaggt gtcgtaaatg agcatcatgg atcttcaggg tctggaggtg
    13081 ccgggcgagc gtgacgccca ggcgctcggc tccaccgtca gcaccggctg ctgacccggt
    13141 acccggtggt cccgtgctcc cggcgcgggg ccaccgggtt ccctttttcc gcgtagccca
    13201 actcctcggg gggagagccg agttgaacga ccgtaccgag ccggcggccc gctccctctg
    13261 catcatcggc tgcggccccc gcggcacctc cctcgtcgag cggatcctcg ccaacgtccc
    13321 cgccctgtac ggcgaccggc ccctggacct gcacctcgtc gacccgtacc cgccgggcgc
    13381 cggccgcacc tggcgcaccg accagcccgg cctgctgtgg atgaactccg ccgccgagca
    13441 ggtcaccctc taccccgacc cgagcgtctc ctgcgccggg ccgccgcgcc ccggccccac
    13501 caccgccgag tggctgaccg gcccgctgca cgacggtgcc tacgccgcgc gccgcgacca
    13561 gggccgctac ctgcgccact tcttcgagac ggtgaccgcc gggcgcccct cctcggtccg
    13621 cctgtacgtc caccgggcgc gcgcgatcga cctgcgccgg acgtccgtgg acggcgcggc
    13681 accggccacc cgccaacagg tggtcctcga ctccgccgaa ccgcccttcc tcgccgaccg
    13741 ggtggtgctg gcgcaagggc acccggacgt gcgtaccgag cccgcaccgg ccggcctgac
    13801 ccgcatcggg ccgggccccg ccgaccccgc cgccctggac gccgtcccgc ccggcgcgcc
    13861 ggtcgtcgtc cgcggcctcg gcctggtctt catcgactgc ctcgccctgc tgacggaagg
    13921 ccgcggcggc cgcttcgacc gcaccccgga cggccggctc cgctacctgc cctccggtcg
    13981 cgagccccgc ctgtacgcgg gctcccgccg cggtgtcccc ctcccgccca agccggcccg
    14041 cgccgccgta ccgtcccggc ccgccgcccc gcgcttcgcc accgccgacg cctgccgggc
    14101 ccggttgtcc cgccccggcg ccaccttcgg ccgcgacgtc tggccgctgg tcctggccga
    14161 gttgggctgg tgccactacc gcgcgctctt cgccgaacag cccgcccgcg cccgtatgac
    14221 gtgggacgac ttcgacgccc agtacgcgct cctgctcacc gacgcggacc gcctcgccaa
    14281 gctcgcccgg gaggccgttc cggaccccgc cgaccgcctc gacctcgacc gcctgtccgc
    14341 cccgctcgcc ggccgccgct tcgccgacgc cgacggcctc cagcgctggc tgcgcgcgca
    14401 cctcgccgag gtccaccacc gccgcaccgg cccggcccgg gctgtcacca ccgcgctggt
    14461 ggacggcctc cagcgcaccg gcgcggtcat cgaggacctg tggcgctccg gcgacctggc
    14521 cggtgaccag ctggcggacg cgctcgcccg cttctccctc ggcacgtacc tgagttccgg
    14581 ccccccgccc ctgcgcgccg agcaactgct cgccctggcc gaggccggag tggtggtgtt
    14641 cgtgggcccc gagatgcgcg tggagatcac gacgccggcc acggacggca ccggcccggt
    14701 cttccgcgcc accagccccg cggtgcccgg cgtcgcccac gacgccgccg tcctcctcga
    14761 cgcccggttg tcggcccccg cccccgaccg cttcgcggac ccgctgctcc gtgccctcct
    14821 ctcccgcggt gaactcaccg aggcccacac ggaggacggc accccgaccg gcgaactccg
    14881 gctgtccggc cccgacctgc acccggtcga cgcccacggc accacccacc acgaccgcgt
    14941 catcgccggc ccggcccagt tcccccgccc ggggacggac gcgatcttct tccggcagaa
    15001 cgatggggtt gcgcggagct tgctggcgcg gcttgatccc cccacgtagt tggctttccc
    15061 gccgtggggg ttgctcgccg ttgcgctttg cggcgcctcc cacgtacctg tctgcggcgc
    15121 cgcgggtcgt ctcgccgttg cgcctgcggc gggctgggtg ggtgtcgggt gcggggacgg
    15181 gcctccgggg ccggttgtgg ggactgctga cgctttacgt ccccacaacc ggcccctccg
    15241 gcccgtcccc tcccgctggg ggggaagttg aggccggtgg gggtacccgt gatccgctta
    15301 ccgtgcgggc gtggccggcc actgggtgtc ggggaagatg gcggcgtcgg agtcggtgtc
    15361 cggcatgagg ctggtgagca tctgctgggc ggtcttcgcg tggtcggcgg cgcgcggcag
    15421 catgacgctc tcgtaggcgt cgagggcctg gtcgacggtg gggtggtcga tgacggcctg
    15481 ggcgagttcg gcgccgtcga gcagggcgag gttggcaccg acgccgaccg gcggcatcag
    15541 gtgggcggcg tcgccgagca gggtgatgcc ggggacgcgc tgccacgtgt gcggaacggg
    15601 gagcacgaac atcgggcggt tgatgaaggc gccctcgttg tcgcgcagga tggccagcaa
    15661 gctctcgtcc cagccctggt actgggcgag gaggcgggcg cgtacggctt cggtgtcggc
    15721 gaggtcgagg ccggcgtgcc agtcctgggg cccgcggaag gtgacgtagc cgcggacgtg
    15781 tccgttgctg ttgcgctgca gcaccaggct gcggcggccc gccttggccg acatggtgcc
    15841 gctgccgacc aggcgggcga tgccggggtg ccggcggtcg acgtcgtcga agtggatctc
    15901 caccatcgtg accccggcgt aggacggttg ggcgtcggag agcgcggggc gcacccggga
    15961 ccacgcgccg tcggcgccga tgaccaggtc gaagtccccg acggtgcggt cgtggtggtg
    16021 cagccggacg gtgccgtcgg gcagcggggt gacggcctcg gcaccgtggc cccagcggac
    16081 ggtgccgggc gcgagggagt ccagcaggag ggcgcgcagt tggccgcggt cgatctcggg
    16141 cttgctcagg tcgtcctcgc cggcccggtc gtgacgtatc agggccgcgt gacggtcgta
    16201 gaggcgccat tgctggcctt cgggccggga cagcgcgcgg aaccggtcga agagtccggc
    16261 cgcgcgcagg gcgacctggc cggtgtcttc gtggatgtcg agggtgccgc cctgcgagcg
    16321 ggagcggggg tcgctctcgc gctcgaagac cgtgaccggc aggccgtgct gctgcaggac
    16381 acgcgcgcag acgaggccgc cgggaccggc gccgatgatc gcgatgcgag gggtggtgga
    16441 catgggggtc acgctccgtt ccacggatcg agagggtgcg gagcaaccac agaagcacag
    16501 cggctacaaa agtacaactg attcgatttc ctatccgact tcctttccga tcgagtcacc
    16561 tcagctgggg tagggtgggg gcatggccga gacgacgaca gggcgccgcg agcgcaagaa
    16621 ggcccagacc aggcaggccc tggcggatgc cgcgctgcgg ctgttcacgg aacgcggcta
    16681 cgacaacgtc ggtgtccgcg acgtggcgga ggcggccgac gtctcgctga gcacgctctt
    16741 caagcacttc cccagcaagg aagccctcgt cttcgacctg gacgcggacg tcgagagcgc
    16801 cctggtcgcc gccgttcgcg accgggtccc tggtcagccc gttctgcacg ccctgcgtga
    16861 ccacctggtg cggacccgta cggccctgcg ggccgacgac cccgtcttcg tcctcgtcga
    16921 atccactccc gcgctgcggg atgccgcccg gcgcatgtgg tcgcgccacg agaaggcgct
    16981 ggccgccacg ctcgccgacg ccaccgggct gcccccggac gacctcgcca tcaccggcct
    17041 ggcccgcttc gccctggagg cccccaccct cgcccgcacc agccccgacc cggcccaggc
    17101 catccgcgac ctgttcgccc tcctggagca cggctgggcc acgaccccct tggcccgcgg
    17161 cgaggaccac cccggcgagg acggctgacc gcgtacgcgg ctagatcccc tgctgctgcg
    17221 ccaggatcgc cgcctgcacc cggctgcgca ggttcagctt cgacaggatg cggctggtgt
    17281 gggtcttcac cgtgccctcg gcgaggttga gggatgcggc gatggcgctg ttggggaggc
    17341 cgcgggcgat gcaggcgagg acttcgcgtt cgcgtttggt gagggtgtcg agggcctggg
    17401 tggtgccctg cggcagggtc gggcgggccg acggggggcg gtgggcgaac tcggtgatca
    17461 ggcggcgggc gatggccggg gtgaggaagc cctcgccgtg ggcgacctcg cgtacggcgc
    17521 cgaccaggac ggtcggctcg gcgttcttga ggatgaagcc gcccgcgccg gcgcgcaggg
    17581 cgccgaagat gtactcgtcg atgtcgaagg tggtcaggac gaggacctcg gcgagttgcc
    17641 gttcgacgat caggcgggtc gcggcgaccc cgttgagcag gggcatctgg atgtccatca
    17701 ggaccacgtc ggggcgcagc tcgtcggcca tgcggaccgc cgcctcaccg tcgccggcct
    17761 cgccgacgac ggtgatgccg ggatcggtct gcagcacgag gaccaggccg gaccggacgg
    17821 cggcctggtc gtcggccacc aggacccgga tgtgcggggg ccgttcggac gattgctccg
    17881 ccggctggtc cgtccgcccg tccgccgccg tgtcctgcac caggtcctcc cgtatggctc
    17941 gccgtgcccg taatgcctgc accgattcgt tcacgttggt ccgcctctcg gccgctgggc
    18001 ctctcgtcgt cgcccccgtt ccggttcgtt aggtgttctg ggtcaggggg agcaccgcgc
    18061 gcacccgcca gcgtcccggg gcggtgcggt cgggccccgc gtcgaagatg ccgccgacca
    18121 gggcggcccg ctcggacatc ccggtcagcc cggcgcccgc gccggtggtc agcgcggcca
    18181 ccgggcgctg ccgggtgcgg gcgtcgggca gcgccagcgg gctgtcgacc gagatggtca
    18241 gccgctcggt gccggcctcg cagcggatcc gcacccggcc cgacgaggcg tgcttgagga
    18301 cgttggtcag cgcctcctgc acgatgcggt acgcggtcac ctcgatcacc gacgagacct
    18361 cggggaaggt ctcggggaac tcggtgtgga gggtcagcgc ggcggcgtcg gcggccgggc
    18421 gggcctgttc gaccagggcg cccagggcgt tgagctgcgg ccggtcccag tcgtcgtcga
    18481 cgccccggtc ggagcggagc agcaccacca tgcggcgcat ttcggccagc ccctgcacgc
    18541 tgttctcccg gatgacggcc agggcgcgca gtaccgggtc gtcctccccg gacccggcgg
    18601 attccccgga cccggcggat tccccggacc cggcgcatcc ggcttcgccg ttccggtccc
    18661 gccgggcctc ggtcagggag agcaccgcac tggagtggat ggcgatcgcg ctgaggtggt
    18721 tggccaccag gtcgtgcagt tcgcgggcca tccgggtgcg ttcggtctgc aggatggtct
    18781 tgcggtccag ttccgcgagc cggttgatct gcgcggcgcg ctcccgctcg gagtcggcgc
    18841 gctccttgtg gttgcgtatc aggatgccgg tccacaccgg ggagatgagc agcatggcga
    18901 cgatgacgcc ggtggtcacg ccctcggaac ggtcgctgat ggcgatcagg gtgatggtgg
    18961 tggcgatggt gaccgcgacc gtcccgaact gcagcacccg gcacagccag ggcgcgccgt
    19021 acagcgccgc ggcgtagagc aggtcggtgt agaccaggac cgggccgagg ccgccgctcg
    19081 acgtcatttc cacgaggacg gtgacggtgc cgaccgagac cgcggccgtc ggcagggtgc
    19141 tgcggaaggc gctcgcggtg cacagcacca cgaccggcag gacggcctgc cagacgggga
    19201 tgtcgcccat gacccgggag ccgcccagga cgtagagaat cagacaggcg gcgaagaagc
    19261 ccacggccag tctgaggtca cggagcggca ggggaggccg gcgcgcgttc gtacctctga
    19321 aaagacgtaa ccacacacga ggacagtact tccgggcgtt gcccgttctc ctggccctgg
    19381 cgcccgaatt tgggtcggtc tcccgtacat cgaagtatgt agccggacat cagcaggagg
    19441 gatgactcga aggatccgga ggatctgcaa accttgggct gtctgtatcg atcgatgtag
    19501 gtggaatagg gggagactcc aactgcttga cgggctgcca ctcacccagg gcagtcttgg
    19561 caccgctcac cagtggagga cggaaagtac gtggaaacga acgccgctct tctcgaactc
    19621 tgtccgggat accttgacca ggacgtcccc ggccgcccgc accaccccgc ccggccccgc
    19681 ctggcgcccc tcgcccccgt ccccatattc atcgtcccga tcggcgagga cggcccctcc
    19741 ccgtcgtccc cgtccgctct cgtcccctcc ccctccctgt cgtacctgcc ctccgccccc
    19801 tcctccgccg gctcgccctc ctccctccgc ggctcgggca gtgcactgtc cccggacagc
    19861 tgtctggggc tcaacggcca ttccgcggcc accctcgacg acgcctcgcg ccgctggctg
    19921 ctgtccgggc tccccgcccg ggtgagcacc gcgatggccg aggcctccta ctgggagctg
    19981 tacggaacgc gcggcctgct ggtcgtggcc tgcggggagg acgcccggca gatgggcttc
    20041 tcggtggagt cggtgcggcg cgggagtccg ccgccgcaca ccccgtgcga agtgctgacc
    20101 gcccgggaac tgcgcgccgc ggaccgtttc ccggagaccg agcgggagcg gatgatcacc
    20161 cgcttctggg tccgcaagga cgccgccatg caggccgccg gcggggggct gtccagcgct
    20221 ccggagcgca tcgaggcggg cttcccggcg gaccacggca cggtcaccgt gcccggcccc
    20281 tacggctgtg acgttccggt ttcggtacgg aacttcacct tctccccctc ctacgagttc
    20341 gcggtggcga ccccggaacc gctcccgctc gccccttcct tcgcctattc ggtcagctga
    20401 atgcccgttc ccacatccgg cccgggaatc cggtcggcgg ggaattcccg ccactggccg
    20461 gaattcgggc cataacgcgg gcgggcgtgg gcgacggcac cgtaacggac cactacggca
    20521 ccggaagcgg acgggcaatg gaccacccgg gtgaaactcg cgcatgtcgc acctcccgga
    20581 catgccgaaa accatattgc cgggttactt ggtgcgtgcc caccggtcgt ggcgagtagc
    20641 gcgtcacggc gccgccggag cacagcggag gaatcccgtg atgccgtcgc ccctcgccaa
    20701 gcgatccgcc cacaccctcc tgtccgtgct gctcgccgtg cttgccgtcg tcggcctcgc
    20761 cgcgcaccgg gccgccgcgg ccgcgccgtc cgggccggtg cccgactggg agcggatcgc
    20821 cgactgcgag agcaacggcc gctggcacat caacaccggc aacggctacc acggcggcct
    20881 gcagatcgac cccgccacct ggcgcgccta cggcggcagg cgctacgccc cgcgggccga
    20941 cctggccacc cgctccgagc agatcgccgt cggccggcgc atcgtccgcg accgcggcct
    21001 ctccgcctgg ccgcgctgcg cctacaccca gcagtccccc agggcctcct ccccgggcca
    21061 gcaggccccg ccggccgccg ccccggacca gccggccccg cggacctccg ccccgccccc
    21121 gcagaccgcg cggaccacgg atccggcaca gcaaccgccc gccgacgacg accagttggc
    21181 cccaccggcc ccgtcgcccg ggtcccatcc cgccgtccgc gccgcggcgt accaccaccc
    21241 caaccacgcg acctacgtcg tccgcaccgg tgactgcctc tccgtcatcg ccgagcggaa
    21301 ccaggtcccc ggcggcaccc aggccctcta cgagctcaac aagcacaagc tcccgcacgg
    21361 cccggaccac atcttcccgg gccagcggct gcgcctgcgg gcgtagcgga cctcccggga
    21421 cctcggcgca ccgccacccg tacgtggccg tcgccgaact gccggaccgg tcagttcctc
    21481 ctcgccgtcc acgccgacca ggacgccgga cgaacccggc gccgagggtg tgcagcaggc
    21541 cattcgccgg gccgtttacc cggcggtggg gagacggatc cggtcggcgc gcggccaccg
    21601 cggccgggtt tgccggggtg cggcggtcca ccagggatgc cggcaaagcg agggccgtca
    21661 cggtgaatcc agtggtcgga gagggtgaat gagagggacg ggccgttgct caggcttggt
    21721 acaggcgggc tcgcccggta gcaagaccgc gggttcatcc accgcgaagt gcaggagcgc
    21781 acagtgaaga agagaacacg cgtcagcatc gtgatcgcag gagcttgcgg catgctcctg
    21841 gccgccggcg gggtcagccc cgccctggcc tgggacggcg ggtacggggg gttcggaacg
    21901 ggcggcaacg tgatcgacag cgacgtctgg gcctccttcc actccatcat ccgctgctcg
    21961 ccacgggccc gggtctgcgt caacggaccg gtcaactccg gtaatacgaa gaactcgcag
    22021 aacgtccata tgtccggcaa caacagcgac agcggcagcc cgaccaacag caacggcaac
    22081 accaacgtcg acagtggtgg cacgacgggt gccgagaacc acaccggcaa cgacatccag
    22141 cacaacggcc ccggatcgac caggatctga cggccaatcg cggcggcccc gcttcccggt
    22201 tcgtaccggg aagcggggcc gctgtgtgtg gtgcggacgg gtcagggatg cagcttgagg
    22261 atcttctgga cggtgttgcc gctgccctgc tgggcgccgc tgaccaggtt ggagctgttg
    22321 gtcgagccgt tggtgttcgc gaagttgccg ctgtggttcg ggttgccgtg gttgatgaag
    22381 ttgccgctgt gcacgctgtt gccgctgtgg accggcccgt tgatgcaggg ctgcggcgac
    22441 ggcgagttga tcctggggga cttgtagtgg aaatcggcca ggcggttgtt gcacatcacg
    22501 cccgaaacca tgccggtgat ggtgccgagg tcggccccta ccgccgccga cagcagtgat
    22561 tcgcccggaa tggtcacggc ctgggcggtg ttggtgctga gcagcaccag tccgcacgct
    22621 ccgatgacgg tgcccgcctg cgcaagtctt ctcacgatgc tccctcgcct gttcatcgtt
    22681 cc
//
