LOCUS       NZ_AP026073            22247 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 chromosome.
ACCESSION   NZ_AP026073
VERSION     NZ_AP026073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8253039)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7450800
            Orig. end                         :: 7473047
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026073.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22247
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="25"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22247
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22247
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12247](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12247)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(476..2527)
                     /locus_tag="HEK616_RS33095"
                     /old_locus_tag="HEK616_67470"
     CDS             complement(476..2527)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014053943.1"
                     /locus_tag="HEK616_RS33095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67470"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_261957513.1"
                     /transl_table=11
                     /translation="MHLRSSRRRPVRTETPPAPAPTEAFAPPAASTPPAPQPAWDHASV
                     GGGPERQPPDREPASEGFGRGLWGPLADPTIRTRRVGLKESLRRFWPLTKGDRRWLLLV
                     CLCAVAAALTETAAILLFAQLTDNALQKGSVSAFWQPAGLWLTVAVIGAVVGYLGNSLA
                     AWTAERFVMRLRARVFAHLQTLPPHFFQRNRRGDLVERLTGDVDAIEQLVVSGLVQAAT
                     ALFGVIFYAGAALWLRWDLALATFVLAPVFWSATRRFTGRVKEVSRRERAADGAITSVV
                     EEGLVNVVLTQAYNRRHEEEKRLDRQARAWFRASVTSARLNELYEQVVELLETLCVLAI
                     IGLGAWEISAGRMTLGQLLAFAAFVGYLYPPIRSLGQLGLTATEATAGSERLLEILDAR
                     PAVTDPPPSLVAPPRFTRALGEIEVRHVGFHYPDSPDEVLHDLSFTAVPGELLVLTGPS
                     GAGKSTLAALLLRFYDPDTGTVRLDDIPVHQMPLAQLRRNITLLPQDTLVLHDTIEENI
                     GCGRPHATHEDVVRAARAADAETFISALPDGYRTVIAPGTARLSGGQLQRVAIARAMLR
                     DAPVLVLDEPTTGLDILATQRILAPLRRLAEGRTTLVISHDLDLATDADRILVLDRGRL
                     VESGTHPELLAHNGLYSTLFHAHPPGHNGQPAPPPSLAGQPGAGAWHG"
     gene            complement(2661..2792)
                     /locus_tag="HEK616_RS33100"
                     /old_locus_tag="HEK616_67480"
     CDS             complement(2661..2792)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS33100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_67480"
                     /product="hypothetical protein"
                     /protein_id="WP_261956531.1"
                     /transl_table=11
                     /translation="MSFRKVFPRRNRRDWDRDRDRYRRRRRRYGRRHNRRRFFDYDY"
     misc_feature    complement(2881..2895)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.37"
                     /tool="antismash"
     misc_feature    complement(2890..2904)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.14"
                     /tool="antismash"
     misc_feature    2891..2904
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.4"
                     /tool="antismash"
     misc_feature    2892..2905
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.39"
                     /tool="antismash"
     misc_feature    complement(2912..2928)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    2913..2929
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.21"
                     /tool="antismash"
     misc_feature    complement(2925..2943)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 16.63"
                     /tool="antismash"
     gene            complement(2987..4501)
                     /locus_tag="HEK616_RS33105"
                     /old_locus_tag="HEK616_67490"
     CDS             complement(2987..4501)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020554299.1"
                     /locus_tag="HEK616_RS33105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67490"
                     /product="MFS transporter"
                     /protein_id="WP_261956532.1"
                     /transl_table=11
                     /translation="MPNHPLSKSSGPARPLPARPAGPPAAPYPRRRTALAALLLAEAMN
                     LLDSTIMTVAAPVIHADLGGPASGIPWYSAAYTLPFAVLLITGGRLGDIAGRRRLLRLG
                     IAGFVLASTVCALAVSPAMLIAARAVQGAAAALVIPQTIGLIRAMFHGDALARAMGSIG
                     PVMGLAAVCGPVLGGVLTHADLLGSSWRAVFLVNLPLGLAVLAATPLLPEDRSERRPRL
                     DLTGTALAVLGTGLLVQPLLDDGLPRFALRPWAVLAGGLAVLTVFGLQQRRRARKGRSA
                     LVEAGLFRGRGFPAALAASLLFFAVVNGLMMVVVLQLQLGLHTDARSSGLTLLPWSAAM
                     AVASWSAGAHLVPRYGSRVMFAGLAALLAGALAAVAVYATAPAASYPWPLPVALAVCGL
                     GQGLFAVPFFTTALHRVRPHETGSAAGLLNAAQQLGGTLGTALLGAVFFHAFSGPAVPS
                     AGVTGALFALHGVRDAFWAAVALLTCTVVAAAGMRSSPVAATAGDR"
     gene            4655..5650
                     /locus_tag="HEK616_RS33110"
                     /old_locus_tag="HEK616_67500"
     CDS             4655..5650
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573581.1"
                     /locus_tag="HEK616_RS33110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67500"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_261956533.1"
                     /transl_table=11
                     /translation="MPLDEIDRGLIHALHLDGRAPFSRIAEVLGVSTQTVARRYRRLSA
                     EAGLRVVGLADPHRAGRAQWLVRLTATPHSAQDLARALARRPDTSWVKLASGGTEIIAV
                     VHTPAGGADGRSLLLHDIPRTAGIAAVSAHYLLHTYLGGPTAWRGRANVLDARQRRQLA
                     PPARENAAPSPSAGAAPADGDQALLAALQRDGRAGQAELAAATGWSPATVARRLAALRA
                     SGALFFDVECDDALFGATTQALLWMTVAPARLEQVATALARHDELAFVAATTGRTNVVA
                     HALCSDPAALHRYLTHRLGGQRAIHALETAPVLRTVKAAGPLVAPPTRAR"
     gene            complement(5681..6067)
                     /locus_tag="HEK616_RS33115"
                     /old_locus_tag="HEK616_67510"
     CDS             complement(5681..6067)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540868.1"
                     /locus_tag="HEK616_RS33115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67510"
                     /product="VOC family protein"
                     /protein_id="WP_261956534.1"
                     /transl_table=11
                     /translation="MKSPVIAPCLGVPDTQAACDYYERLGFTALPGTDDSDDDLRILLF
                     DGAFAFMVYRDQHLRGWLPVLKDTPVGAFGMFYLAVEDFEAYVERIRPLVSVTKDVLTH
                     HGQKLFYFTDLNGYVVGVTQRQTW"
     gene            complement(6125..6901)
                     /locus_tag="HEK616_RS33120"
                     /old_locus_tag="HEK616_67520"
     CDS             complement(6125..6901)
                     /EC_number="3.2.2.-"
                     /EC_number="4.2.99.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673912.1"
                     /locus_tag="HEK616_RS33120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67520"
                     /product="Fpg/Nei family DNA glycosylase"
                     /protein_id="WP_261956535.1"
                     /transl_table=11
                     /translation="MPELPDVEGFRRTLVACARGRVIRRIEVYDEGVLHGVSRQRLRGE
                     LEGRRFTEPERHGKWLLAHTGGPTLLLHFGMTGRLVCCSPDDPVHPHDRVVFTLGRERQ
                     LRYRDQRKLQGLWLMDPAGTERILSRQGPDAGKVGRADFRAALAGRRGSLKAVLMDQSV
                     LAGLGNLLVDEILWRTGLRPGRRAGDLSADDCDRLHTEMRRTLRAAVRAGRVPPRDSWL
                     TGRRDDPGPSCPRCGTPLRRTRVAGRGTVWCPRCQP"
     gene            complement(6935..7672)
                     /locus_tag="HEK616_RS33125"
                     /old_locus_tag="HEK616_67530"
     CDS             complement(6935..7672)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS33125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_67530"
                     /product="chitin-binding protein"
                     /protein_id="WP_261956536.1"
                     /transl_table=11
                     /translation="MRRKTALLGAVALTGALSAALAVSVPPTARATTGTIIFHMRPGNR
                     QYQIVDPGDDHCYGLGPGGGGVVNDTPLDLVLWPSRDCTGNPMATVRAGTEAVFARYGS
                     LQLAPSDDYQEDPPAADPPRDEDPPRDEDPPRDEDPPRDEDPPRDQDPSGDQDPSGTEN
                     PPGDQNLPPGSENPPSAVHPPSAKPSSPPAARHSSTHPSTHPSTHPSAPSVRRPARHSS
                     PHSSPHTARHSSPHAARHSSRHA"
     gene            complement(7702..9861)
                     /locus_tag="HEK616_RS33130"
                     /old_locus_tag="HEK616_67540"
     CDS             complement(7702..9861)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981083.1"
                     /locus_tag="HEK616_RS33130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67540"
                     /product="nuclease-related domain-containing DEAD/DEAH box
                     helicase"
                     /protein_id="WP_261956537.1"
                     /transl_table=11
                     /translation="MTAGGSAAGSAAGGSASRRAQEARRQERLLREQWRAARQRAERWE
                     AASEGERRIAAQLLMLTERGWRLLVDRRWPGTRAANVDMLLIGPGGVFVIDVKNWRAAP
                     EPSGGRLRAGGFSRDEHRRKLLAVTKAAEGAVAALGMSPVAVRPLMAFAGQRVDTELGR
                     LRLLGEHEIGPALLSERTRLSAGSVRALAEHLGRVFPEYEDPAADRTGARTARHRAGTT
                     PAAPSPADDGLFDLDGLRQAALDEARRAPIERWMTFLDPDQLALVRRNWAGPARISGPA
                     GTGKTVVALHRAAYLAQRTGGRVLYVTFANNLPRVQATFLTTMAPAVADRIEFSSLHHW
                     AQTYLQSRDVPVRLHREKAETAFSLAWKHLGRDSCLAEIDPLPRYWKEEIDHVIKGRGI
                     TSFDEYAALPRLRRRTSLRHPHRQAVWALYEAYEAQRRERVVHDFNDVLSLALAETAGR
                     GGHSPYTAVVVDEVQDLTLVGVRLLHSLVGDSPNGLLLVGDGQQAVYPGGFRLSDAGID
                     IRGDRGQVLRANYRNSKEIVDTALSVVAGDAFEDIDGSRTPGRRDVDLTYHHGEVVRAV
                     LPSPAAHDAALVAVLRGLTPQELADSAVLCPATRAIERYRRLLTRAGVRVCLLESYDGR
                     PVAAVKLGSYRRAKGLEFKRVYLPRHEANLTDGKEAEEDGGTAREQGELMRSQLFVAMT
                     RARDVLWLGSVRPSGTAGESARREE"
     misc_feature    complement(9772..9774)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12247)
                     /locus_tag="HEK616_RS33135"
                     /old_locus_tag="HEK616_67550"
     CDS             complement(10001..12247)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971162.1"
                     /locus_tag="HEK616_RS33135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67550"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_261956538.1"
                     /sec_met_domain="T1TS (E-value: 2.8e-83, bitscore: 279.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYTPHPARLNPHLEAARTHSRRWAREMGMLEGSGIW
                     EQRDLDAHDYALLCAYTHPDCDADALSLVTDWYVWVFFFDDHFLETFKRTLDREGGKQY
                     LDRLPAFMPMDDATPVPEPTNPVEAGLADLWARTVPHMSLDWRRRFAESTEHLLNESLW
                     ELSNININRVPNPVEYIEMRRKVGGAPWSAGLVEYAAGAEVPAAVAASRPLRVLRDAFS
                     DGVHLRNDLFSYQRETEDEGELSNGVLVLETFLGCTTQEAADAVNDLITSRLQQFENTV
                     VTELPALFLETGLDAGSCADVLAYAKGLQDWQSGGHEWHLRSSRYMNGGGAAAAGSAQP
                     WSPFAAAGLGTSAADLRTALSTAGALRFRSHTHVPHQKVGPSRIPDITMPFALSLSPHL
                     DGARRRVIDWAHRMGMLRPQPGVPLSDVWDEPAMARHDLALCAAGIHPDATPDELDLGS
                     QWLAWGTYADDYYPQVFGRTRDIAAAKVCTERLSAFMPLDAAAPVPEPVNALERGLADL
                     WPRTVAAMAPPARRDFRQAVDVMTASWLWEIDNQIQNRIPDPVDYIEMRRATFGSDLTM
                     SLCRIGHGRRVPPEVYRTGTVRALENSAADFACLMNDVFSYQKEIEYEGEVHNGVLVVQ
                     NFFQCDYPSALAIVGDLMTSRIEEFQHIAAKELPVVHDDFGLSAEAREVLDGYVHELEN
                     WMAGILNWHRGCRRYLASELRHPMGAPGWPGVPEGLGTSAFRPVRRPVPSVGQP"
     misc_feature    complement(12279..12297)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 20.85"
                     /tool="antismash"
     gene            complement(12409..13278)
                     /locus_tag="HEK616_RS33140"
                     /old_locus_tag="HEK616_67560"
     CDS             complement(12409..13278)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604222.1"
                     /locus_tag="HEK616_RS33140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67560"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_261956539.1"
                     /sec_met_domain="RimK (E-value: 8.6e-10, bitscore: 37.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGLITADPAHPVLAAATGVLTGDGHRVEHLDPDGEAPGPDRGA
                     LADVYLLKARTPRALALAARLESYGVPVLNSAAATARCQDRVAMAELARTAGLPFAATR
                     PVDAIEELAAAGEPAGPLVVKSRYSRRGDLVARADTAAELRELAAAWPEEPVVVQEFTA
                     NSGWDHKLWVVDGRLFAGLRRSELAPDGRGPTRPLPPGDLPAGWAELALRTGGVFGLAV
                     YGVDVLLGPDGPVVVDVNAFPGIRGQAGAPEALAELALRTARTALPARTACATPTTGET
                     NTRRRKSV"
     gene            complement(13275..14183)
                     /locus_tag="HEK616_RS33145"
                     /old_locus_tag="HEK616_67570"
     CDS             complement(13275..14183)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536574.1"
                     /locus_tag="HEK616_RS33145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67570"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_261956540.1"
                     /sec_met_domain="RimK (E-value: 4.2e-07, bitscore: 28.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.3e-05, bitscore:
                     23.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLCFLVEEQYRHDGMPRDVIRQLGAWGHQVDVVWPGRSLIPISE
                     SVRAGSHDAWVLKTVSGGPGLTLLEAAAAVGLTTVNDARAIRGVRDKALAAVIARTHGL
                     PVPVTYAAARAEEFAELPPSAFPLVVKPADGSSGRAVRLVESPGRLTGPDAPEQAGGLL
                     IAQPYVPNSGTDLKVYCVAGELYATERCSPLHPGHDVPERQVPLTAEVAGIAAEIGAVF
                     GLDLYGVDVLLGPDGPVVVDINDFPSFRQVPDAVARVSAAVLRLAGGGGGNGTGRGLPV
                     PAAAAPPAPETVPLAAIGGDR"
     misc_feature    14315..14332
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(14432..14446)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.09"
                     /tool="antismash"
     misc_feature    complement(14433..14446)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.12"
                     /tool="antismash"
     gene            14540..15991
                     /locus_tag="HEK616_RS33150"
                     /old_locus_tag="HEK616_67580"
     CDS             14540..15991
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467918.1"
                     /locus_tag="HEK616_RS33150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67580"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_410011297.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.1e-40, bitscore:
                     137.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANEQHSGFGRRGFLAGMGGLIGASGLGGTSPAAAAAPHHGPRPE
                     DFHGHRQLLVPELLLLPEGPVRDRAVLVSGGTFRAVGPAEALIAAHRDLEPVRLDGHLL
                     MPGFVDAHHHLTQSFGKAQSFGQPSEIFKTVWEPLEHALDEESAYVSAKLAALEALRGG
                     FTTVADAGTRAPVDVAAIARGTEEAGIRCVLSKIVSDGTGGPAHLERWDGHPLVHPSLA
                     IAVPEDAPAGTLKRTAALCTEAGAVLQIHVNEHLASVERSLKSVGRRPVEYLHHIGALG
                     PHTLGAHATLLTPTEMRLLADSGAAISYNPVASAWKGNGVAHATMLAALGVRFGMGTDG
                     TRGDGFRLIDAGETAQRLAYGLGSGDSVCGAGRMWLDHATTHSADAVGLGKVTGEIAAG
                     KAADYLVVDLDVPELTPSYDLRWELVRLANRDQIAAVVVAGRLRLWHGRPTDWDAQALV
                     ARAAKLGPQVVERAGLQRVEPVYES"
     gene            complement(16035..17462)
                     /locus_tag="HEK616_RS33155"
                     /old_locus_tag="HEK616_67590"
     CDS             complement(16035..17462)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471097.1"
                     /locus_tag="HEK616_RS33155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67590"
                     /product="MFS transporter"
                     /protein_id="WP_410011298.1"
                     /transl_table=11
                     /translation="MCLCVTLVVGMVSAVNLALPDLSASALRPSAQAVVWVVDGYVVVF
                     ACLLVPAGALADRWGRKGTLLCGLGVFALGAVVCAVAARVGWVIAGRMLSGVGAAAVLP
                     TTLALLVEGREDRARRRAIAVWASMTGLAAVLGNVGGGAAIEFGSWRTLFRCVVPLALG
                     ALLLVAAVAPAGVAGGRPHPVPAGGSALFTGGFLALLYGIVSGPGEGWGSPVVLGAFGA
                     AGLLLAGWARSELRSVRPLLDPRLFARPAVRAGAVGMAALFTGMFGLFYLNGQYLQYAK
                     GYGPFGAGLRLLPMAGALLAGPRCGLLLERAVGRRGAVVVGMLVLAGGLCTVSAADART
                     PYPRYALGAGLTALGCGIATPLLSHAMMAALPPERAGTGSGLQSLSRELGSAVGIAVTG
                     TVTTAVFTARLPAALAGPGAPTTVAAAEARTSDPGVRDAVVTAFTDGLHSATLTLAAAL
                     AVTAVPVACWMPGERGR"
     gene            complement(17509..18267)
                     /locus_tag="HEK616_RS33160"
                     /old_locus_tag="HEK616_67600"
     CDS             complement(17509..18267)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986277.1"
                     /locus_tag="HEK616_RS33160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67600"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_261956542.1"
                     /transl_table=11
                     /translation="MAAEQGRRADQARRVAHVLRGQVLRGAFPDGVLPDERALVAEFGT
                     SRNTVREALGLLRDEGLVERRRGVGTVVAGRTYQHPLGELSGLAEVLQRHGVVVNEVRE
                     ARSVRPPLAVARRLGLAEGAAAVYLERLRRVDGAPLSLDCTYLIPEVGEPLLARGRATL
                     ERQDVFDLIERVAGAPLGRAEVSVRAVVADPATCEVLAMPEGGAVLAVERLTRLADGRP
                     ADLEFIHLRGDRLTLQATLDRARGVNSVVE"
     gene            18545..19033
                     /locus_tag="HEK616_RS33165"
                     /old_locus_tag="HEK616_67610"
     CDS             18545..19033
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089892.1"
                     /locus_tag="HEK616_RS33165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67610"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_261956543.1"
                     /transl_table=11
                     /translation="MTHKAVPFDDLDRKIIAALLDNGRASFAEIGTAIGLSSTAVKRRV
                     DRLREHNVITGFSATVRPAALGWLTEAYVEVYCDSAAPPRRLAEVVRNHPEIAAAMTVT
                     GGADALLHVRATDVEHFEEVLERIRTEPFIRKTISYMVLSHLLPDSPEAGAQAANKRI"
     misc_feature    19110..19130
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.08"
                     /tool="antismash"
     gene            19290..20081
                     /gene="ddaH"
                     /locus_tag="HEK616_RS33170"
                     /old_locus_tag="HEK616_67620"
     CDS             19290..20081
                     /EC_number="3.5.3.18"
                     /GO_function="GO:0016403 - dimethylargininase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ddaH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662066.1"
                     /locus_tag="HEK616_RS33170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67620"
                     /product="dimethylargininase"
                     /protein_id="WP_261957515.1"
                     /transl_table=11
                     /translation="MCEPRHFDVRYAINPWMREGTPVDTALAARQWEALADAYRAHGHT
                     VETVPPVPGLPDMVFAANSALVVNGRVFGSRFHAPQRRPESTEYETWFKAAGYDVYRPE
                     ALCEGEGDLVPAGRYVLAGTGFRTSRAAHDEVQEHFGVPTIGLQLVDPYFYHLDTALFV
                     LSEDPGTGDAEIAYYPGAFSSGSREVLRRLFPGAVLATRDDAMAFGLNSVSDGRHVFVA
                     PPATALIDQLAARGYVPVPVDLSEFHKAGGGIKCCTQEIRS"
     gene            20078..21328
                     /gene="rocD"
                     /locus_tag="HEK616_RS33175"
                     /old_locus_tag="HEK616_67630"
     CDS             20078..21328
                     /EC_number="2.6.1.13"
                     /GO_function="GO:0004587 - ornithine aminotransferase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (42-363). E-value: 7.1e-103.
                     Score: 336.1. Matches aSDomain:
                     nrpspksdomains_HEK616_RS33175_Aminotran_3.1"
                     /codon_start=1
                     /gene="rocD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671272.1"
                     /locus_tag="HEK616_RS33175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67630"
                     /product="ornithine--oxo-acid transaminase"
                     /protein_id="WP_261956544.1"
                     /sec_met_domain="Aminotran_3 (E-value: 9.3e-117, bitscore:
                     388.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPVRTAPAPTAPVGAPRSSAELIRAEGPVLAHNYHPLPVVVAR
                     AEGVWVEDVEGRRYLDMLAGYSALNFGHRHPALIEAAHRQLDQLTLTSRAFHNDRLAGF
                     AEALAELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPADRATIVVADGNFHGRTT
                     TIVGFSDDTTARTGFGPFAPGFRTVPYNDLAALEAAVDDTTAAVLIEPIQGEAGVIIPD
                     QGYLTGVRELTRRAGCLFIADEIQSGLGRTGTTLAVEHESVVPDVLLLGKALGGGIVPV
                     SAVVARREVLGVLGPGQHGSTFGGNPLAAAVGSAVIELLATGEFQRRAAELGEQLRTGL
                     AALTGKGVTGFRARGLWAGVDIDPALGTGREISERLLAEGILVKDTHGSTIRLAPPLTI
                     TSEELASALTSLERALA"
     aSDomain        20204..21166
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS33175_Aminotran_3.1"
                     /evalue="7.10E-103"
                     /label="HEK616_RS33175_Aminotran_3.1"
                     /locus_tag="HEK616_RS33175"
                     /protein_end="363"
                     /protein_start="42"
                     /score="336.1"
                     /tool="antismash"
                     /translation="VARAEGVWVEDVEGRRYLDMLAGYSALNFGHRHPALIEAAHRQLD
                     QLTLTSRAFHNDRLAGFAEALAELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPA
                     DRATIVVADGNFHGRTTTIVGFSDDTTARTGFGPFAPGFRTVPYNDLAALEAAVDDTTA
                     AVLIEPIQGEAGVIIPDQGYLTGVRELTRRAGCLFIADEIQSGLGRTGTTLAVEHESVV
                     PDVLLLGKALGGGIVPVSAVVARREVLGVLGPGQHGSTFGGNPLAAAVGSAVIELLATG
                     EFQRRAAELGEQLRTGLAALTGKGVTGFRARGLWAGVDID"
     gene            complement(21356..21937)
                     /locus_tag="HEK616_RS33180"
                     /old_locus_tag="HEK616_67640"
     CDS             complement(21356..21937)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020550108.1"
                     /locus_tag="HEK616_RS33180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_67640"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_261957516.1"
                     /transl_table=11
                     /translation="MRILDAAEGLFYGRGIQAVGMDELRAAAGVSLKRLYQCFPAKRDL
                     VEAYLLRRDARWRAALAEYVDARGGGPEGRVPAVFDWLAEWFAEPDFRGCAFLNSFGEL
                     GATSEEVARAAREHKRALVSYLDGLVSDLPGELPVRQRALLAGQLALLVDGAISAAAVA
                     GEAGAARQARAAAEVLLAAARSDGAEPAAS"
ORIGIN
        1 tgacgatccg tacggcttct ccttctcggg gctgaagacc gctgccgcac ggtgggccga
       61 gcggcaccag gggcgggcgc tgccggtggc ggacggtgcc gccgcgctcc aggaggcggt
      121 cgccgacgtg ctgacccgta aggcggtggc ggcctgcacc gcccacggtg tcggcacgct
      181 cgtcgtggtc ggcggggtgg ccgccaactc ccgggtccgg gcactggcgg aggagcggtg
      241 cgcggcggcc gggatcgccc tgcgggtgcc gccgctgaag ctgtgcacgg acaacggcgc
      301 gatgatcgcc gccatcgggg acctgctcgt ccgggcgggc gcggagcccg cgccgctgga
      361 tgtctcgatc gatccgtcgg ctcccctgga gtacgccgca ctgcatccgg tggcccgcgc
      421 cgccgcggcg gccggcgctc cctgacgccg taccgccgct cccggtcccc gcgtctcagc
      481 cgtgccaggc ccccgccccc ggctgtcccg ccaggctggg cggcggtgcc ggctgcccgt
      541 tgtggcccgg cgggtgggcg tggaagagcg tggagtacag gccgttgtgg gccaggagtt
      601 cggggtgggt gccggattcg acgaggcggc cccggtcgag gacgaggatg cggtcggcgt
      661 cggtggcgag gtccaggtcg tgggagatca cgagggtggt gcggccctcc gcgaggcgcc
      721 gcaggggggc gaggatgcgc tgggtggcca ggatgtccag gcccgtcgtg ggctcgtcga
      781 ggacgaggac gggggcgtcg cgcagcatgg cgcgggcgat cgcgacgcgc tgcagctggc
      841 cgcccgagag ccgggcggtg cccggggcga tgaccgtgcg gtagccgtcc gggagggcgg
      901 agatgaaggt ctcggcgtcg gcggcgcggg cggcgcggac cacgtcctcg tgagtggcgt
      961 gcgggcggcc gcagccgatg ttctcctcga tggtgtcgtg caggacgagg gtgtcctggg
     1021 ggagcagggt gatgttgcgg cgcagctggg cgagcggcat ctggtggacg gggatgtcgt
     1081 cgaggcggac ggtgccggtg tcggggtcgt agaaccgcag cagcagcgcg gccagggtgg
     1141 acttgccggc gccgctgggg ccggtgagga ccagcagttc gccggggacc gcggtgaagg
     1201 agaggtcgtg caggacctcg tcggggctgt cggggtagtg gaagccgacg tgccggacct
     1261 cgatctcgcc gagggcgcgg gtgaagcgcg gcggggcgac gagggacggc ggcgggtcgg
     1321 tgaccgcggg gcgggcgtcg aggatctcca gcaggcgctc ggagccggcg gtggcctcgg
     1381 tggcggtcag gcccagctgt cccagggagc ggatgggcgg gtagaggtag ccgacgaacg
     1441 cggcgaaggc gagcagctgg cccagggtca tccggccggc ggagatctcc cacgcgccga
     1501 ggccgatgat cgccaggacg cagagcgttt cgagcagctc gacgacctgc tcgtacagct
     1561 cgttgaggcg ggcgctggtc accgatgccc ggaaccaggc gcgggcctgc cggtccagcc
     1621 gcttctcctc ctcgtgccgg cggttgtacg cctgggtgag cacgacgttg accaggccct
     1681 cctcgacgac cgaggtgatc gcgccgtccg ccgcgcgctc ccggcgggac acctccttga
     1741 cccggccggt gaagcggcgg gtggcgctcc agaacaccgg tgccagcacg aacgtggcca
     1801 gcgcgaggtc ccagcgcagc cagagggccg cgccggcgta gaagatgacg ccgaagaggg
     1861 cggtggccgc ctggacgagc ccggagacca ccagctgctc gatggcgtcg acgtcgccgg
     1921 tgagccgctc gaccaggtca ccgcgccggt tgcgctggaa gaagtgcggc ggcagcgtct
     1981 ggagatgggc gaagacccgg gcacgtaggc gcatcacgaa gcgctcggcg gtccaggcgg
     2041 cgagcgagtt gccgaggtag cccaccaccg cgccgatgac ggccacggtc agccacagcc
     2101 cggccggctg ccagaaggcg ctgaccgagc ccttctgcag ggcgttgtcg gtgagttggg
     2161 cgaagaggag gatggccgcg gtctcggtga gcgcggcggc gacggcgcac aggcagacca
     2221 ggagcagcca gcgccggtcg cccttggtca gtggccagaa gcggcggagc gactccttga
     2281 gtccgacgcg ccgggtgcgg atggtgggat cggccagcgg gccccacagg ccccggccga
     2341 atccttcgga ggcgggctcc cggtccgggg gttgccgttc cgggccgccc ccaacggacg
     2401 cgtgatccca ggccggttgg ggcgctggcg gtgtcgacgc cgccggcggt gcgaaggctt
     2461 cggtcggcgc cggggccggt ggcgtctcgg tgcgcaccgg ccgccgtcgc gagctgcgca
     2521 gatgcatgat ggccacgccg tatcagtcag ctggtcggac cgggcggaaa ggccgctgag
     2581 gggccctcac gcacatccgc tcaaacgcac gaggcggacc cgcgcgccac gcgagcctgc
     2641 ctcgaactca gaggtgtggg tcagtagtcg tagtcgaaga aacggcgcct gttgtgccgg
     2701 cggccgtacc tgcggcgacg cctcctgtag cggtcccggt cacggtccca gtcgcgcctg
     2761 ttcctgcgcg ggaagacttt ccggaagctc atgctgcctc cttgattgtt tcctttccga
     2821 cgccccgtta ccggtggcgt caactcccaa gctacgtcgc ccacctactg acaacaagga
     2881 aaatacgtga aatttcagac gaaagctgaa attcttaatt ttcctgcaca gagtggacaa
     2941 ttcatcactc tccgcagccg cctttccccg gtcccggatc gcccgttcac cgatcacccg
     3001 ccgtggccgc cacgggactt gaccgcatac cggccgcggc gacgacggtg caggtgagca
     3061 gggcgaccgc ggcccagaag gcatcgcgta cgccgtgcag cgcgaagagc gcgccggtga
     3121 cgccggccga cgggaccgcg gggccgctga aggcgtggaa gaagaccgcg ccgagcagtg
     3181 cggtgccgag cgtgccgccg agctgctggg cggcgttgag cagcccggcc gccgagcccg
     3241 tctcgtgcgg ccggacccgg tgcagcgcgg tggtgaagaa cgggacggcg aacagcccct
     3301 gtcccagccc gcagaccgcc agcgccaccg gcagcggcca cgggtaggag gcggcggggg
     3361 cggtggcgta gacggcgacg gcggccagcg cgccggcgag cagtgcggcg agcccggcga
     3421 acatcacccg ggagccgtag cggggcacca gatgggcgcc ggcgctccag gacgccaccg
     3481 ccatcgcggc cgaccagggc agcagggtga gcccggacga ccgggcgtcg gtgtgcaggc
     3541 cgagctggag ctgcagcacg acgaccatca tcagaccgtt caccaccgcg aagaacagca
     3601 gcgaggcggc cagcgcggcg gggaagccgc ggccgcggaa cagtcccgcc tcgaccagcg
     3661 cgctacggcc cttacgcgca cggcggcgct gctgcagccc gaagacggtc agcacggcga
     3721 gcccgccggc caggacggcc cagggccgga gcgcgaagcg gggcagcccg tcgtcgagga
     3781 gcggctggac gagcagtccg gtgccgagga cggccagcgc cgtgccggtg aggtcgagcc
     3841 gcggccgccg ctccgagcgg tcctcgggca gcagcggggt cgcggcgagg acggcgaggc
     3901 cgagcgggag gttgacgagg aagaccgccc gccaggacga gccgagcagg tcggcgtggg
     3961 tgagcacccc gccgagcacc ggcccgcaga ccgcggccag ccccatgacc gggccgatgc
     4021 tgcccatggc ccgggccagc gcgtcgccgt ggaacatggc ccggatcagc ccgatggtct
     4081 gcgggatgac cagggcggcc gcggcgccct ggacggcccg cgcggcgatc agcatcgccg
     4141 gggagacggc cagcgcgcag accgtggagg ccaggacgaa gccggcgatc cccaggcgga
     4201 gcagccgccg gcggccggcg atgtcaccga gccggccgcc ggtgatcagc agcaccgcga
     4261 agggcagcgt gtacgcggcg ctgtaccagg ggatgccgga cgccggaccg ccgaggtcgg
     4321 cgtggatcac cggcgccgcg accgtcatga tcgtggagtc gagcaggttc atcgcctcgg
     4381 cgagcagcag cgccgccagc gcggttcggc gccgggggta cggcgcggcc ggcggaccgg
     4441 ccgggcgggc cggcagcggg cgggccggcc cggagctctt cgacaagggg tggttcggca
     4501 tggggtgtcc cttcggccgt cacggatgca cggccgagcc tgcgggcgcg tacggtgaac
     4561 gttccagcca gggggttcca ctcgcagttt ctttccacca cgggcccgtt cggcgaggaa
     4621 ttcgtccatc cgtgcacggc caggaggccc gggtatgccg ctcgacgaga tcgaccgcgg
     4681 gctcatccac gcactgcacc tcgacggccg ggcgccgttc agccggatcg ccgaggtgct
     4741 gggcgtctcg acgcagaccg tggcccgccg ctaccggcgg ctgtccgccg aggccggtct
     4801 gcgggtcgtc gggctggccg atccgcaccg cgcgggccgg gcccagtggc tggtccggct
     4861 caccgcgacc ccgcacagcg cccaggacct cgcccgtgcg ctggcccggc ggccggacac
     4921 ctcgtgggtg aagctcgcct ccggcgggac ggagatcatc gccgtggtgc acaccccggc
     4981 cggcggcgcc gacggccggt ccctcctgct gcacgacatc ccgcgcaccg ccggcatcgc
     5041 cgcggtctcc gcgcactacc tgctgcacac ctacctcggc ggccccaccg cctggcgcgg
     5101 ccgcgcgaac gtcctcgacg cccgacagcg tcgccaactc gcgccaccgg cacgggagaa
     5161 cgccgccccc tccccctccg cgggcgccgc gccggccgac ggcgaccagg cgctgctggc
     5221 cgcgctgcag cgggacggcc gggccggcca ggccgaactt gccgcggcca ccggctggtc
     5281 accggccacc gtcgcccgcc ggctggccgc cctgcgggcc tccggtgcgc tgttcttcga
     5341 cgtcgaatgc gatgacgcgc tgttcggcgc caccacgcag gcgctgctct ggatgacggt
     5401 ggcccccgcc cgcctggagc aggtcgccac cgccctggcc cgacacgacg aactcgcctt
     5461 cgtcgccgcc accaccggcc ggacgaacgt ggtcgcgcac gccctctgtt ccgacccggc
     5521 ggccctgcac cgctacctca cccaccgcct cggcggccag cgcgcgatcc acgccctgga
     5581 gaccgcaccg gtgctccgca ccgtcaaggc ggccgggcca ctcgtcgccc ctcctacgag
     5641 ggcacgttga cgcgccgtcg accggggccg gggccccgcc tcaccacgtc tgccgctggg
     5701 tgacccccac cacgtaaccg ttgaggtcgg tgaagtagaa gagcttctgg ccgtggtggg
     5761 tcagcacgtc cttggtgacg ctgaccaggg ggcggatccg ttcgacgtag gcctcgaagt
     5821 cctcgacggc caggtagaac atgccgaacg cgcccaccgg ggtgtccttg aggaccggga
     5881 gccagccgcg caggtgctgg tcccggtaga ccatgaacgc gaatgcgccg tcgaagagca
     5941 ggatgcgcag gtcgtcgtcc gagtcgtcgg tgcccggcag ggcggtgaag ccgagcctct
     6001 cgtagtagtc gcaggccgcc tgggtgtcgg gcacgcccag gcacggggcg atgacggggg
     6061 acttcatcgg ggctcctcct cggggtgatc gcctcgggcc acggcacggc acggtacgtc
     6121 gggttcacgg ctggcagcgg gggcaccaca ccgtgccccg cccggcgacc cgcgtccggc
     6181 gcagtggtgt gccgcagcgc gggcaggacg ggccggggtc gtcgcgccgg ccggtgagcc
     6241 aggagtcgcg cggcgggacg cggcccgccc ggaccgccgc ccgcagggtg cggcgcatct
     6301 cggtgtgcag ccggtcgcag tcgtcggcgg acaggtcacc ggcgcggcgg ccgggacgca
     6361 ggccggtgcg ccagaggatc tcgtcgacca gcagattgcc gagcccggcg aggaccgact
     6421 ggtccatgag gacggccttg aggctgccgc gccgcccggc gagcgcggcc cggaagtccg
     6481 cccggcccac cttccccgcg tccgggccct ggcggctcag gatccgttcc gtaccggccg
     6541 ggtccatgag ccacaggccc tggagtttgc gctggtcgcg gtagcggagc tggcgctcgc
     6601 ggccgagcgt gaagaccacc cggtcgtggg ggtggaccgg atcgtccggg gagcagcaga
     6661 ccagccgtcc ggtcatcccg aagtgcagca gcagggtggg gccgccggtg tgcgcgagca
     6721 gccatttccc gtggcgctcc ggctcggtga accggcgccc ctccagctcg ccgcgcagcc
     6781 gctgccggct caccccgtgc agcacgccct cgtcgtacac ctcgatccgc cggatcaccc
     6841 ggccccgcgc acacgcgacg agcgtccgcc ggaagccctc gacgtccggc aactcgggca
     6901 tccggcccac cgccccttgg gaggtcggcc tttgctacgc gtgacgcgac gagtgccgcg
     6961 ccgcgtgcgg cgaggagtgc cgggccgtgt gcggggacga gtgcggggac gagtgccggg
     7021 cggggcgccg taccgagggc gctgacggat gcgttgacgg gtgcgtcgac ggatgcgtgg
     7081 acgagtggcg tgccgcgggc ggtgacgagg gcttggccga cggcgggtgg acggcggacg
     7141 gcgggttctc ggaacccggt gggaggttct ggtcgcccgg cggattctcg gtacccgacg
     7201 ggtcctgatc acccgacggg tcctggtcgc gcggcggatc ctcatcccgc ggcggatcct
     7261 catcccgcgg cggatcctca tcgcgcggcg ggtcctcatc gcgcggcgga tcggccgccg
     7321 gcgggtcctc ctggtagtcg tccgacgggg ccagctgcag gctgccgtag cgggcgaaca
     7381 ccgcctccgt gccggcccgg acggtggcca tcgggttgcc ggtgcagtcg cgcgagggcc
     7441 acaggacgag gtcgagcggg gtgtcgttca ccaccccgcc gcccccgggc ccgaggccgt
     7501 agcagtggtc gtcgccgggg tcgacgatct ggtactgccg gttgcccggc cgcatgtgga
     7561 agatgatggt gccggtggtg gcccgcgccg tgggcggtac ggacacggcg agcgccgcgc
     7621 tgagcgctcc ggtgagggcc acggcgccga gaagagcggt cttgcgtcgc atggacccaa
     7681 cgttcccgag accgttttgt cctattcctc ccggcgcgca gattcacccg ccgtgccgct
     7741 cggccggacg ctgcccagcc acagcacgtc ccgcgcccgg gtcatcgcca cgaagagctg
     7801 gctccgcatc agttctccct gctcacgggc ggtcccgccg tcctcctccg cctccttccc
     7861 gtccgtcagg ttcgcctcgt gacggggcag atagacccgc ttgaactcca gccccttggc
     7921 cctccggtag ctgcccagtt tcaccgccgc gaccggccgc ccgtcgtaac tctccagcag
     7981 gcacacccgt acgcccgccc gggtcagcag ccgccggtag cgttcgatgg cgcgggtggc
     8041 ggggcacagc accgcggagt ccgccagttc ctgcggggtc aggccgcgca gcaccgccac
     8101 cagcgccgcg tcgtgcgccg cgggcgaggg cagcaccgcg cggaccacct cgccgtggtg
     8161 gtacgtcagg tcgacgtccc gccggcccgg ggtccgcgag ccgtcgatgt cctcgaaggc
     8221 gtccccggcg acgacggaca gcgcggtgtc cacgatctcc ttgctgttgc ggtagttggc
     8281 gcgcagcacc tgcccccggt cgccgcggat gtcgatcccg gcgtccgaga gccggaaccc
     8341 gccggggtag acggcctgct ggccgtcgcc caccagcagc agcccgttgg ggctgtcccc
     8401 caccagggag tgcagcagcc gcacgccgac cagggtgagg tcctggacct cgtccacgac
     8461 gacggccgtg tacggggagt ggccaccgcg gccggccgtc tcggcgagcg cgagggagag
     8521 cacgtcgttg aagtcgtgca ccacgcgttc tctgcgctgc gcctcgtacg cctcgtagag
     8581 ggcccagacg gcctgccggt gcggatggcg caggctggtg cggcggcgca ggcggggcag
     8641 tgcggcgtac tcgtcgaagg aggtgatccc gcggcccttg atgacgtggt cgatctcctc
     8701 cttccagtag cggggcagcg gatcgatctc cgccaggcag ctgtcccggc cgaggtgctt
     8761 ccaggcgagg ctgaaggccg tctccgcctt ctcccggtgc aggcggaccg gtacgtcgcg
     8821 ggactggagg taggtctgcg cccagtggtg caggctgctg aattcgatcc ggtcggccac
     8881 cgcgggggcc atggtggtga ggaacgtcgc ctgcacccgc ggcaggttgt tggcgaaggt
     8941 gacgtacagg acgcggccgc cggtgcgctg ggcgaggtac gcggcgcggt gcagcgcgac
     9001 caccgtcttg ccggtgccgg ccgggccgct gatccgggcc gggccggccc agttgcggcg
     9061 caccagcgcg agctggtcgg ggtcgaggaa ggtcatccac cgctcgatgg gggcccgccg
     9121 ggcctcgtcc agggcggcct gccgcagccc gtcgaggtcg aagaggccgt cgtccgccgg
     9181 ggagggtgcg gccggcgtgg tcccggcccg gtgccgcgcg gtccgggcgc ccgtcctgtc
     9241 ggccgccggg tcctcgtact cggggaagac ccggcccagg tgctcggcga gcgcccgcac
     9301 cgagcccgcg gagagccggg tgcgttccga cagcagcgcc gggccgatct cgtgctcgcc
     9361 cagcagccgc agccggccca gttcggtgtc gacgcgctgg ccggcgaagg ccatcagcgg
     9421 gcggaccgcc accggtgaca tgcccagcgc cgccaccgcg ccctcggcgg ccttggtgac
     9481 cgcgaggagt ttgcgccggt gctcgtcacg ggagaacccg ccggcccgca gccgcccgcc
     9541 ggacggttcc ggggcggccc gccagttctt gacgtcgatg acgaagaccc cgccgggccc
     9601 gatcagcagc atgtccacgt tggcggcccg ggtgcccggc cagcgccggt ccaccagcag
     9661 ccgccagccc cgctcggtca gcatcagcag ctgggcggcg atccgccgct ccccctcgct
     9721 cgccgcctcc cagcgttcgg cccgctggcg ggcggcccgc cactgctccc gtaacagccg
     9781 ctcctggcgc cgggcctcct gggcccgccg tgatgccgat ccgcccgccg cgctccccgc
     9841 cgccgacccg cctgccgtca tcccgcgccc cctcacctcg ccccgcgtcc cacggggtca
     9901 tgaaccatag gtccggggca cctgacgcgg tagtgcgcac agcaggggca cgggggcatg
     9961 gcgcgggccc gtggtccgcg gtcccacggg cccgccgccg ctacggctgt ccgacgctcg
    10021 gcaccggccg ccgcacgggc cggaacgccg aggtgccgag gccctccggg acgcccggcc
    10081 agcccggcgc gcccatcggg tggcggagtt cggacgcgag gtagcggcgg cagccgcggt
    10141 gccagttgag gatgccggcc atccagttct ccagctcgtg gacgtagccg tcgagcacct
    10201 cacgggcctc ggcggacagc ccgaagtcgt cgtggacgac cgggagttcc ttggcggcga
    10261 tgtgctggaa ctcctcgatg cgcgaggtca tgaggtcgcc cacgatggcc agcgcgctcg
    10321 ggtagtcgca ctggaagaag ttctggacga cgaggacgcc gttgtgcacc tcgccctcgt
    10381 actcgatctc cttctggtac gagaagacgt cgttcatcag gcaggcgaag tcggcggcgg
    10441 agttctccag cgcgcgcacg gtgccggtgc ggtagacctc gggcggcacc cggcggccgt
    10501 ggccgatccg gcacagggac atggtgaggt cggacccgaa ggtcgcccgc cgcatctcga
    10561 tgtagtcgac cgggtcgggg atgcggttct ggatctggtt gtcgatctcc cagagccagc
    10621 tggccgtcat gacgtcgacg gcctgccgga agtcccggcg cgccggtggc gccatcgccg
    10681 ccaccgtgcg gggccacagg tccgcaagtc cccgttcgag ggcgttgacc ggctccggga
    10741 cgggcgcggc ggcgtcgagc ggcatgaacg ccgacagccg ttcggtgcag accttggccg
    10801 cggcgatgtc ccgggtccgg ccgaagacct gcgggtagta gtcgtcggcg taggtgcccc
    10861 aggccagcca ctgggagccg aggtcgagtt cgtccggggt ggcgtccgga tggatgccgg
    10921 ccgcgcacag cgccaggtcg tggcgtgcca tcgcgggctc gtcccagacg tcggagagcg
    10981 gcaccccggg ctgcggccgc agcatgccca tccggtgcgc ccagtcgatg acccggcggc
    11041 gggcgccgtc caggtgcggg ctcaggctga gggcgaacgg catggtgatg tcggggatcc
    11101 gggacgggcc gaccttctgg tggggcacgt gggtgtggct gcggaagcgg agcgcgccgg
    11161 cggtgctcag cgccgtcctc aggtccgccg ccgaggtgcc cagaccggcg gcggcgaacg
    11221 gcgaccaggg ctgcgcggat ccggccgccg ccgctccgcc gccgttcatg taccggctgg
    11281 agcgcaggtg ccactcgtgg ccgccggact gccagtcctg cagccccttg gcgtacgcca
    11341 gcacgtccgc gcaggacccg gcgtccaggc cggtctccag gaacagcgcg gggagttccg
    11401 tgaccacggt gttctcgaac tgctggagcc gggaggtgat caggtcgttg accgcgtccg
    11461 cggcctcctg ggtggtgcag cccaggaagg tctccagcac caggacaccg ttgctcagct
    11521 cgccctcgtc ctcggtctcc cgctggtagg agaagaggtc gttgcgcagg tggacgccgt
    11581 cggagaaggc gtcgcgcagc acccgcagcg gccgggaggc ggcgaccgcg gccgggacct
    11641 cggcgccggc cgcgtactcg accaggcccg cggaccaggg cgcgccgccg accttgcggc
    11701 gcatctcgat gtactcgacg gggttgggca cccggttgat gttgatgttg gacagttccc
    11761 agagggactc gttcagcagg tgctcggtgc tctcggcgaa ccgccggcgc cagtccagcg
    11821 acatgtgcgg cacggtgcgg gcccacaggt cggcgaggcc cgcctcgacc gggttggtcg
    11881 gctccggtac gggcgtggcg tcgtccatcg gcatgaaggc gggcagccgg tcgaggtact
    11941 gcttgccgcc ctcccggtcc agggtgcgct tgaacgtctc caggaagtgg tcgtcgaaga
    12001 agaagaccca gacgtaccag tccgtcacca gcgagagcgc gtccgcgtcg cagtcggggt
    12061 gggtgtacgc gcacagcagg gcgtagtcgt gggcgtcgag gtcccgctgc tcccagatgc
    12121 ccgagccctc cagcatcccc atctcgcggg cccaccggcg ggagtgtgtg cgcgccgcct
    12181 ccaggtgcgg gttcagccgc gccgggtggg gcgtgtagaa gtggggcaat tcaaatggct
    12241 gtgtcaccgt tgctggcctc tccccatacg tgcggaagga aggcgcgccg aaccacgccc
    12301 cctcaacgga gccagcgcta ccccggggtc cggcgcgtta gacgttgcgg aggacgagcc
    12361 tccacgaccg ccgctttctg cccgttcgac cccgcgccaa tgatcacttc agacgctttt
    12421 ccgacgccgc gtgttcgttt ccccggtcgt gggggtggca caggcggtac gggcggggag
    12481 agcggtgcgg gcggtgcgca gggcgagttc cgccagtgcc tccggcgcgc ccgcctgccc
    12541 ccgtatgccg gggaaggcgt tgacgtcgac gaccaccggg ccgtccgggc cgagcagcac
    12601 gtccacgccg tagaccgcca ggccgaagac cccgccggtg cgcagcgcga gctcggccca
    12661 gcccgcgggc aggtcaccgg gcggcagcgg ccgggtcggc ccgcgcccgt ccggtgccag
    12721 ctccgagcgg cgcagcccgg cgaagagccg cccgtcgacc acccacagct tgtggtccca
    12781 gccgctgttc gcggtgaact cctggaccac caccggctcc tcgggccagg cggccgccag
    12841 ttcccgcagc tcggcggcgg tgtcggcgcg ggccaccagg tcgccgcgcc ggctgtaccg
    12901 gctcttgacc accagcggcc cggccggctc cccggccgcc gccagctcct cgatcgcgtc
    12961 caccggccgg gtcgcggcga acggcagccc cgccgtccgc gccagctccg ccatcgccac
    13021 ccggtcctgg caacgcgccg tcgccgcggc ggagttgagc accgggacgc cgtacgactc
    13081 caggcgcgcg gccagcgcca gcgcccgcgg cgtccgcgcc ttgaggaggt acacgtcggc
    13141 gagcgcgccg cggtccgggc cgggcgcctc gccgtccggg tccaggtgct cgacccggtg
    13201 gccgtccccg gtcagcacac cggtggccgc ggccagcacc gggtgcgccg gatccgccgt
    13261 gatcaggccg atcctcaccg gtcgccgccg atcgccgcca gcgggacggt ctccggcgcg
    13321 ggcggcgccg cggcggccgg caccggcagg ccgcggcccg tgccgttccc gccgcccccg
    13381 ccggcgagcc gcagcaccgc cgccgacacc cgggccaccg cgtccggcac ctgacggaag
    13441 ctcgggaagt cgttgatgtc gacgaccacc ggcccgtccg ggccgagcag cacgtccacg
    13501 ccgtagaggt cgagcccgaa gaccgcgccg atctccgccg cgatcccggc gacctcggcg
    13561 gtgagcggca cctggcgctc cggtacgtcg tgcccggggt gcagcggcga gcaccgctcg
    13621 gtggcgtaca gctcaccggc gacgcagtag accttcagat cggtaccgga gttggggacg
    13681 tacggctgcg cgatcagcag cccgccggcc tgctccggcg cgtccggccc ggtcagccgg
    13741 ccggggctct cgaccagccg caccgcgcgc cccgagctgc cgtccgcggg cttcaccacc
    13801 agcgggaacg cgctgggggg cagctccgcg aactcctcgg cccgggccgc cgcgtaggtc
    13861 accggcaccg gcaggccgtg ggtgcgggcg atcaccgcgg ccagcgcctt gtcccggacg
    13921 ccgcggatcg cccgggcgtc gttgaccgtg gtcagcccga ccgcggcggc ggcctccagc
    13981 agggtcagcc ccggcccgcc cgagacggtc ttgaggaccc aggcgtcatg gctgccggcc
    14041 cgcaccgact cggatatcgg gatcagcgag cggcccggcc acacgacgtc cacctgatgg
    14101 ccccaggcgc cgagttggcg gatcacgtcc cggggcatgc cgtcgtggcg gtactgctcc
    14161 tccaccagga agcagagtct catcggggca tcctcgtcat cgccgcgcgt ccgtccaccg
    14221 tccgcccggc agatccatga cgcaccagga tcccacgcgg ggcccggcag ggaccgtgag
    14281 ggcccgtacg ccgctacgga tccccgcccg ccccatgttt cggcgaggtt acgccaccct
    14341 ccccgcccgg tccgcccctc ctgaccaggc gcgccaccgc caccgcccgg cccagcgcca
    14401 ccccccgccc cacctcgtaa atcccgtatg ccggaaccct tgttccgctt ctggcccggt
    14461 cctagggtcg ggccaccccg gggacggatc ggcgaacggt acgcaccacg taccggagta
    14521 cgggaagcag gcgagcgggt tggcgaacga acagcacagc ggattcggcc ggcggggatt
    14581 cctggccggc atgggcggac tcatcggcgc atcgggactc ggcggtacga gcccggccgc
    14641 ggccgccgca ccccaccacg ggccgcggcc cgaggacttc cacggccacc ggcagctgct
    14701 cgtgcccgag ctgctgctcc tgcccgaggg cccggtgcgc gaccgcgcgg tcctcgtctc
    14761 cggcgggacg ttccgcgccg tcgggccggc cgaagcgctc atcgccgccc accgcgacct
    14821 cgaaccggtc cgcctggacg gccacttgct gatgcccggc ttcgtggacg cgcaccacca
    14881 cctgacccag agcttcggca aggcccagtc cttcggccag ccctcggaga tcttcaagac
    14941 cgtctgggag cccctggagc acgccctcga cgaggagagc gcctacgtct ccgcgaaact
    15001 cgccgccctg gaggcgctgc gcggcggctt caccaccgtc gccgacgccg gcacccgcgc
    15061 ccccgtcgac gtcgcggcga tcgccagggg caccgaggaa gccggcatcc gctgcgtgct
    15121 gtccaagatc gtctccgacg gcaccggcgg ccccgcccac ctggaacggt gggacggcca
    15181 ccccctcgtc cacccctccc tggccatcgc ggtccccgag gacgcccccg ccgggaccct
    15241 caagaggacc gccgccctgt gcaccgaggc cggcgccgtc ctccagatcc acgtcaacga
    15301 gcacctcgcc tccgtggaac gctcgttgaa gagcgtcggc cggcgccccg tcgaatacct
    15361 ccaccacatc ggcgccctgg gcccgcacac cctcggcgcc cacgccaccc tcctcacgcc
    15421 caccgagatg cggctgctcg ccgactccgg cgcggccatc agctacaacc cggtggccag
    15481 cgcctggaag ggcaacggcg tcgcccacgc caccatgctg gccgccctgg gcgtccgctt
    15541 cggcatgggc accgacggca cccgcggcga cggcttccgc ctgatcgacg ccggcgagac
    15601 cgcccagcgc ctcgcgtacg ggctgggctc cggcgactcg gtctgcggcg ccggccggat
    15661 gtggctggac cacgccacca cccacagcgc cgacgccgtc ggcctcggca aggtcaccgg
    15721 cgagatcgcc gccggcaagg ccgccgacta cctcgtcgtg gacctcgacg tccccgaact
    15781 caccccctcc tacgacctgc gctgggaact cgtccggctc gcgaaccgcg accagatcgc
    15841 cgccgtcgtc gtggccggcc ggctccgcct gtggcacggc cggcccaccg actgggacgc
    15901 ccaggccctg gtcgcccgcg ccgcgaaact cggcccccag gtcgtcgaac gggcggggct
    15961 ccaacgggtg gagccggtct acgagtcctg acggcgacgg gcgcgggacc cttcggcccc
    16021 gcgcccgccc ggcctcaccg cccccgctcc ccgggcatcc agcacgccac cggcaccgcc
    16081 gtcaccgcca gcgcggcggc cagggtcagc gtcgcgctgt gcagaccgtc cgtgaacgcc
    16141 gtgacgaccg cgtcccgcac ccccgggtcg gacgtacggg cctcggccgc cgcgaccgtc
    16201 gtcggagcgc ccggcccggc cagcgccgcg ggcagccggg cggtgaagac cgcggtggtc
    16261 accgtgccgg tcaccgcgat gcccaccgcg ctgcccaact cccggctcag gctctgcagt
    16321 ccggacccgg tcccggcccg ctccggcggc agcgcggcca tcatggcgtg cgacagcagc
    16381 ggcgtggcga tcccgcagcc cagcgccgtc agcccggcac ccagcgcata gcgcggatac
    16441 ggggtgcggg cgtcggccgc ggacaccgtg cacagcccgc cggccagcac cagcatgccc
    16501 accaccaccg cgccccgccg cccgaccgcc cgctccagca gcagcccgca gcgcggcccg
    16561 gccagcagcg ccccggccat cggcagcagc cgcagccccg cgccgaacgg cccgtacccc
    16621 ttcgcgtact gcaaatactg gccgttgagg tagaacaggc cgaacatgcc ggtgaacagc
    16681 gccgccatgc ccaccgcccc ggcccgcacg gccggccgcg cgaacaaccg cggatccaac
    16741 aacggccgca ccgaacggag ttcactccgc gcccagccgg ccagcagcag ccccgccgcg
    16801 ccgaacgccc ccagcaccac cggactcccc cagccctccc ccggcccgct gacgatcccg
    16861 tagagcagcg ccaggaaccc cccggtgaac agggcactgc cgcccgccgg gaccggatgc
    16921 ggccggccgc cggccacccc ggccggggcg accgcggcga ccagcagcaa cgcaccgagc
    16981 gccagcggca ccacacagcg gaacagcgtc cgccagctcc cgaactcgat ggccgccccg
    17041 cccccgacgt tccccaacac ggcggcgagc cccgtcatcg acgcccacac cgcgatcgcc
    17101 ctgcgccgcg cccggtcctc ccgcccctcc accagcagcg ccagcgtcgt cggcaacacg
    17161 gccgcggcgc ccaccccgct gagcatccgc ccggcgatca cccaccccac ccgtgccgcc
    17221 accgcacaga ccaccgcgcc gagcgcgaac acccccagcc cgcacagcag cgtccccttg
    17281 cgcccccacc ggtcggcgag cgcccccgcc ggcaccagca gacacgcgaa gaccacgaca
    17341 tagccgtcca cgacccagac caccgcctgc gccgacggac gcagcgcact cgccgacagg
    17401 tccggcagcg ccagattgac cgcggacacc atgcccacca ccagcgtgac gcacaggcac
    17461 atcgcgaccg tcagcgcacc acgccgcccc ggcgcggccc caacccgctc actccacaac
    17521 ggagttgacg ccccgcgccc ggtccagcgt ggcctgcagc gtcaaccggt ccccgcgcag
    17581 atggatgaac tccagatcgg ccggccgccc gtcggcgagc cgggtcagcc gctccaccgc
    17641 gagcaccgcc ccgccctccg gcatcgccag cacctcacac gtcgccggat ccgccaccac
    17701 cgcccgcacc gacacctccg cccggcccag cggcgccccc gccacccgct cgatcagatc
    17761 gaagacgtcc tgccgctcca gcgtcgcccg cccccgcgcc agcagcggct ccccgacctc
    17821 cggaatcaga tacgtgcagt ccagcgacaa cggcgccccg tccacccgcc gcagccgctc
    17881 cagatagacc gccgccgccc cctccgccag ccccagccgc cgggccaccg ccagcggcgg
    17941 ccgcacgctc cgcgcctccc gcacctcgtt gacgaccacg ccgtgccgct gcagcacctc
    18001 cgccagcccg gacagctccc ccaggggatg ctggtacgtc cgccccgcca ccacggtgcc
    18061 gactccccgg cgccgctcca ccagcccctc gtcccgcagc agccccagcg cctcccgcac
    18121 ggtgttccgc gacgtaccga actcggccac cagcgcccgc tcgtccggca gcaccccgtc
    18181 cgggaacgcc ccgcgcagca cctggccccg cagcacatgc gccacccggc gcgcctgatc
    18241 cgcccgccgc ccctgttccg ccgccatccg catccctcct ccctacgccc gcgacgctag
    18301 gggaccggtg ttgccgcgag gttacgccac cccatctgac ctgcacagat tcctgaactg
    18361 ccggtttgcg ggacggcccc ggggctgcgc caccgcccgg cgccggcgga ccgctaccgt
    18421 gaggcgatcg cgcacaccgc gcacaccgtt cggcgatcac gcgctcacac gcgcccgcgg
    18481 cgatcacgca cactgaggcg atcacgtgct cacgcaggac tggtaaggac agggaggtcc
    18541 agccgtgacc cacaaggccg tgcccttcga cgacctcgac cggaagatca tcgcggcgct
    18601 gctcgacaac ggccgggcga gcttcgcgga gatcgggacg gccatcgggc tgtcgtccac
    18661 cgcggtcaaa cgccgggtgg accggctgcg cgagcacaac gtgatcaccg ggttctccgc
    18721 caccgtccgc cccgccgccc tgggctggct gaccgaggcg tacgtcgagg tgtactgcga
    18781 cagcgccgcg ccgccccgcc ggctggccga ggtcgtccgc aaccacccgg agatcgcggc
    18841 cgcgatgacc gtcaccggcg gcgccgacgc cctgctgcac gtgcgggcca cggacgtcga
    18901 gcacttcgag gaggtcctgg agcggatccg gaccgaaccg ttcatccgga agacgatcag
    18961 ctacatggtc ctctcccacc tcctcccgga cagcccggaa gccggcgccc aagcagcaaa
    19021 caagcgcatc tgagcgaaac cacgcaggat tcctgcctac atgcgcagca tttgttgctt
    19081 gtggccggaa tccacccctc cttaccgtgg taaggcccgg gtgacgatca gtgacactgc
    19141 gtcatgaccc atcgatcgcc gtcacccacc tgcctcaccg gagaggaagg gatacttctg
    19201 tgccgacgag tagtgcgacg agcaccccga gcagtgcgaa cagccccgtc ccggcagccg
    19261 cccgcgtggc gcgcccccgc cggtacctga tgtgcgagcc ccgccacttc gacgtgcgct
    19321 acgccatcaa cccctggatg cgcgagggca caccggtcga caccgccctg gccgcccgcc
    19381 agtgggaggc cctggccgac gcctaccgcg cacacggcca caccgtcgag accgtcccgc
    19441 cggtccccgg cctgcccgac atggtgttcg cggcgaactc cgcgctcgtc gtgaacggcc
    19501 gggtcttcgg ctcgcggttc cacgccccgc agcgccgccc cgagtccacc gagtacgaga
    19561 cctggttcaa ggccgccggc tacgacgtgt accgcccgga ggccctgtgc gagggcgagg
    19621 gcgacctcgt cccggccggc cgctacgtcc tcgccggcac cggcttccgc acctcccgcg
    19681 cggcccacga cgaggtgcag gagcacttcg gcgtcccgac catcggcctg cagctggtcg
    19741 acccgtactt ctaccacctc gacaccgcgc tcttcgtcct gtccgaggac cccggcaccg
    19801 gcgacgcgga gatcgcctac tacccgggcg ccttctcgtc cggcagccgc gaggtgctgc
    19861 gccggctctt ccccggggcc gtgctcgcca cccgggacga cgccatggcg ttcggcctca
    19921 actccgtctc cgacggccga cacgtcttcg tcgcgccgcc ggccaccgcc ctgatcgacc
    19981 agctcgccgc gcgcggctac gtccccgtcc ccgtcgacct ctcggagttc cacaaggccg
    20041 gcggcggcat caagtgctgc acccaggaga tccgctcatg accgcacccg tccgcaccgc
    20101 cccggccccc accgcccccg tcggcgcgcc ccgttcgtcc gccgagctga tccgggccga
    20161 gggcccggtc ctggcccaca actaccaccc gctgcccgta gtcgtggcgc gcgccgaggg
    20221 cgtctgggtc gaggacgtcg agggccgccg ctacctcgac atgctcgccg gctactcggc
    20281 actgaatttc ggccaccggc acccggccct catcgaggcc gcccaccgcc agctcgacca
    20341 gctcaccctc acctcccgcg ccttccacaa cgaccgcctc gccggcttcg ccgaggccct
    20401 cgccgagctc accggcctgg acatggtcct gccgatgaac accggcgccg aggcggtgga
    20461 gagcggcatc aaggtcgccc gcaaatgggc ctacgacgtc aagggcgtcc cggccgaccg
    20521 cgcgacgatc gtggtggccg acggcaactt ccacggccgc accaccacca tcgtcggctt
    20581 ctccgacgac accaccgccc gcaccggctt cggccccttc gccccgggct tccgcaccgt
    20641 cccctacaac gacctcgccg ccctcgaagc cgccgtcgac gacaccacgg ccgccgtcct
    20701 catcgagccc atccagggcg aggccggcgt catcatcccc gaccagggct atctgaccgg
    20761 cgtccgcgaa ctgacccggc gggccggctg cctcttcatc gccgacgaga tccagtccgg
    20821 cctcggccgc accggcacca ccctcgccgt cgagcacgaa tccgtcgtcc ccgacgtcct
    20881 cctcctcggc aaggcactcg gcggcggcat cgtcccggtc tccgcggtcg tcgcccgccg
    20941 cgaggtcctc ggcgtcctgg gccccggcca gcacggctcg accttcggcg gcaacccgct
    21001 cgcggccgcg gtcggttcgg ccgtcatcga gctgctcgcc accggcgagt tccagcgccg
    21061 cgccgccgaa ctcggcgaac agctgcgcac cggcctggcc gccctcaccg gcaagggcgt
    21121 caccggcttc cgcgcccgcg gcctgtgggc cggcgtggac atcgacccgg ccctcggcac
    21181 cggccgcgag atcagcgaac gcctcctggc ggaaggcatc ctggtcaagg acacccacgg
    21241 ctccaccatc cgcctcgccc cgcccctgac catcacgtcg gaggaactgg catcggccct
    21301 gacgagcctg gaacgggcct tggcctaggg gccgttacgg ggccaccggc tgtcgctacg
    21361 aggccgccgg ctccgcgccg tccgaccggg ccgccgccag cagcacctcg gcggcggccc
    21421 gcgcctgccg ggccgccccc gcctcccccg cgacggcggc cgcactgatc gccccgtcga
    21481 cgagcagcgc caactggccg gcgagcaggg cgcgttgccg caccggaagc tcacccggca
    21541 ggtcactcac gagcccgtcc aggtagctca ccagcgcccg cttgtgctcc cgcgcggccc
    21601 gcgcgacctc ctccgacgtg gcccccagct ccccgaacga gttgaggaag gcacaccccc
    21661 ggaagtccgg ctccgcgaac cactccgcca gccagtcgaa gaccgccggc acccgcccct
    21721 ccggcccccc gccgcgcgcg tccacgtact ccgcgagcgc cgcccgccac cgcgcgtccc
    21781 gccgcagcag atacgcctcg acaagatccc gcttggccgg aaagcactgg tagagccgct
    21841 tcagcgaaac ccccgcggcg gcccgcagct catccatccc cacggcctga atcccgcgcc
    21901 cgtagaacag cccctccgca gcatcgagta tccgcacccg gacttcgtcg ccatgagccg
    21961 tactggctct gccacgcccc gcaggggccg cgccgtgagc cgcgggggcc gcgccgtggg
    22021 ccgtgggggt ctcgtcgtga gccgtggggg tcttgccgtg agccgtgggg gtcttgccgt
    22081 gagccgtggg ggccttgtcg tgagccgtgg gggtctcgtc gtgagccgta cgggcttctt
    22141 cctggcgcat ggggcacgtc cgggctggtc gggccgaccg gaagccggcc ggggggcggg
    22201 ggaggcgggg gcggggccga tcggggagcc ccctggcgta gagaacg
//
