LOCUS       NZ_AP026073            30941 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 chromosome.
ACCESSION   NZ_AP026073
VERSION     NZ_AP026073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8253039)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4079392
            Orig. end                         :: 4110333
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026073.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..30941
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /product="RRE-containing"
                     /region_number="13"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..30941
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="interleaved"
                     /product="azole-containing-RiPP"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..29008
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:19008](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..19008)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            23..1300
                     /locus_tag="HEK616_RS18170"
                     /old_locus_tag="HEK616_37080"
     CDS             23..1300
                     /NRPS_PKS="Domain: Aminotran_5 (45-382). E-value: 9.3e-37.
                     Score: 118.7. Matches aSDomain:
                     nrpspksdomains_HEK616_RS18170_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012488.5"
                     /locus_tag="HEK616_RS18170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37080"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_261953985.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.2e-29, bitscore:
                     102.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHVSTDPPPIIPARPGENRLWEWAREQFDLDPGYVHLALSMLAP
                     HPRTVREAIAYHRTELDRNPALHFHQRDERVRRVLATAGAYLGADPDSIALTESTTAGM
                     AVVYTGMRLGPEDEILSTRHEHYAASELLRFKAKSSGAGHRCISLYEDGPTATSEEIVS
                     SLVREIRDNTRLLALTWVHSGTGVKLPLSRIGEAVAEVNHGRPTDRQILICVDAVHGFG
                     VEDFTVEELRCDFFMAGCHKWLFGPRGTGVVWGSERGWNAVEPIMTSFDVEVFWPWYLG
                     RTPDAEAPRARLCTPGGFPVFEHRWALAEAFDFQLTLGKKPVAMRIADLNAYCHRRLME
                     TAGITVRTPADRALRSGMTCFDVEGRDPGEIAAMLEKRRIMAGQTPYRDSAVRFAPGIL
                     NSVADIDRAVETLEQIVRAGPQEPPA"
     aSDomain        158..1168
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS18170_Aminotran_5.1"
                     /evalue="9.30E-37"
                     /label="HEK616_RS18170_Aminotran_5.1"
                     /locus_tag="HEK616_RS18170"
                     /protein_end="382"
                     /protein_start="45"
                     /score="118.7"
                     /tool="antismash"
                     /translation="HPRTVREAIAYHRTELDRNPALHFHQRDERVRRVLATAGAYLGAD
                     PDSIALTESTTAGMAVVYTGMRLGPEDEILSTRHEHYAASELLRFKAKSSGAGHRCISL
                     YEDGPTATSEEIVSSLVREIRDNTRLLALTWVHSGTGVKLPLSRIGEAVAEVNHGRPTD
                     RQILICVDAVHGFGVEDFTVEELRCDFFMAGCHKWLFGPRGTGVVWGSERGWNAVEPIM
                     TSFDVEVFWPWYLGRTPDAEAPRARLCTPGGFPVFEHRWALAEAFDFQLTLGKKPVAMR
                     IADLNAYCHRRLMETAGITVRTPADRALRSGMTCFDVEGRDPGEIAAMLEKRRIMA"
     gene            complement(1621..3222)
                     /locus_tag="HEK616_RS18175"
                     /old_locus_tag="HEK616_37090"
     CDS             complement(1621..3222)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008734405.1"
                     /locus_tag="HEK616_RS18175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37090"
                     /product="ISL3 family transposase"
                     /protein_id="WP_261953986.1"
                     /transl_table=11
                     /translation="MEKTVFRLEELLFPSIADVAVLSVGMDEEAIRIEVCSTATGANCP
                     DCGSRSSGPHSSYQRFPADVPSASRKGLLCVRIRRFFCPDPSCGRRTSAEQIPGLTRRH
                     GRWAERLRSALAAVGLALAGRAGARTAKVFGVSVSRSTVLRLLAALPEPDAPSPRADGV
                     DEYANGKGRVYGTVLVDVETRRPIDLLPDREASSLAQWLAKRPGIEVVCRDRAPFFAEG
                     ATAGAPQAVQVADRWHLWHNLGQAAEREVARHRQCLRVLLPEPVKEEVDTTEPFDEIPE
                     SPWRGDRFANRIRARHATVHAMLEAGHSRRSIGRQLRMTHRTVKSLTDAARPEDLFRRQ
                     WQYSRTSALDEYKPYLDERWSEGCTCVWKLWEEIVPLGYKGSYGIVSAYIRKKRTSPRP
                     ITAQPPAPRVVTRWILSRPESLTEIEQLRLKAVLPNCAELDALTGHVRPFAHMLTERRG
                     ERLLEWPDAVRQDDLPSLDTLATGIDRDRDAVIAGLTLPWNSGVVEGHVNRIKMLKRQM
                     FGRAGLQLLRKRVLLS"
     misc_feature    complement(1654..1656)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3844..4695
                     /locus_tag="HEK616_RS18180"
                     /old_locus_tag="HEK616_37100"
     CDS             3844..4695
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS18180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_37100"
                     /product="hypothetical protein"
                     /protein_id="WP_261957579.1"
                     /transl_table=11
                     /translation="MDTGDLISAVSALVAAIAAGVGWWQAHSARRAVKAAEEQANAMRD
                     QVKAAEEQVSVMRDQIVLEHMRPRFEVTHATTMLLPRGGGRLVIEVAQLTGVPLDDVKV
                     ELHVGSRQVMTDGAHDGVHTCLYSAPGSKLTFRAHLDVEAAQAPAVRVELSGTEAQGTR
                     QWAERLIAHPVLTDNRLLTEGRTAAGLPRRASSSRDYSVNDERWRQAPQVSRAPGDVRG
                     RLANLRRGIQQGRSVGSKTKGQGSGPDNASRQDARPGGTTSGGVAPDAAGNDTDPEDDS
                     SR"
     gene            complement(<5173..5573)
                     /locus_tag="HEK616_RS18185"
                     /old_locus_tag="HEK616_37120"
                     /pseudo=""
     CDS             complement(<5173..5573)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="HEK616_RS18185"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="HEK616_37120"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTGFAERIASEELWVLFRRVVPETVVTRPQGGGRRRAGDHECLAA
                     IIFVATSGCSWRQLPPVFGPAWPTVYRRFAQWSKERVWARLHRVILDELGAAGDLDWSR
                     CAINSVSVRAVKGGC"
     gene            5675..6058
                     /locus_tag="HEK616_RS18190"
                     /old_locus_tag="HEK616_37130"
     CDS             5675..6058
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131580.1"
                     /locus_tag="HEK616_RS18190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37130"
                     /product="CPCC family cysteine-rich protein"
                     /protein_id="WP_261953987.1"
                     /transl_table=11
                     /translation="MILTFPCVCCGHLTLGEPPGSYEICPVCFWEDDRVQLRWPNWAGG
                     ANRPSLIEAQANFMEFGACEERFVTKVRLPRDDEPLDPNWRPIDPEQDHFEPRGTQEAP
                     WPDDCTVLYWWRYRDTGSWPRGG"
     gene            complement(6198..>6349)
                     /locus_tag="HEK616_RS18195"
                     /pseudo=""
     CDS             complement(6198..>6349)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129145.1"
                     /locus_tag="HEK616_RS18195"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="ERERKLLQLRFGAEMTQADIGKELNLSQMHISRLLNRACKGCGRA
                     CSPSR"
     misc_feature    complement(6819..6833)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.16"
                     /tool="antismash"
     misc_feature    6820..6834
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.29"
                     /tool="antismash"
     misc_feature    6998..7011
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.64"
                     /tool="antismash"
     gene            7112..9976
                     /locus_tag="HEK616_RS18200"
                     /old_locus_tag="HEK616_37150"
     CDS             7112..9976
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943488.1"
                     /locus_tag="HEK616_RS18200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37150"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_261953988.1"
                     /transl_table=11
                     /translation="MALGEIGRRSEKARLRAVLEESRRDRGPVVAVVRGEPGAGKSTLL
                     DVFGAEASAAGFRVATVRGTGAEDRPYAAANRLIAQLRAGGGKLVEIQHRTPPGDGPGG
                     LIAAVPTERDVPVALCVDNMAQVDSWSLRWLLDLSRTLPPAPLAIVLTVRIWGAGVEAV
                     SGPVDGAWGEPGTALLAAAELIDLPGLLTIDLPEAAAARCRVRLDTRTAAVCGELTGGN
                     PALLHALLAPHTGSAPTADALRTTAASGALAGADRWLAPLSASALALARAVAVLGGGAE
                     VVDSAELARLTVEEALGAVDQLVDACLLANHTPLAFRHPLLETMVLGRIAAGTRTALHL
                     RAAALLRDRQAATTTVAHHLVAAGPVGEEWAMRCLWLAARQLEQKGRPQDAARCLRAAL
                     REPLRPHEKLAVRRELAELDAFVDPERAVRLLDAARCESQDPGVVLEYALALAAVLAEC
                     GRAEDAVTVLDDAAARLGRTPGDGSWQLRLRLHKAFACRRGPLWLAQAADPLGNLTCRT
                     PHRGNAGRELAALRAVQAVDAGADRGAAVRYARQGLPRAEGDGSATLVWRTCGALVAAG
                     EVAEAWTHCGRGRQVVGARPGRWDHIKVELLRAAVLRARGDLHGADTTLTPMADHLLAF
                     AATGHPSAVTGVAALVEVHVLKGLVDSARSLLAESGLDRGPLPWRRDSAYALAARAAVH
                     ESDDPARALEDLLAAGRLLEEVGVRNPAVLPWRSRAARLLAARGERKEAAELAGAEAAD
                     ARRWGTPESIGTALHALALTESGERRIDLLTDAAGMLARSSDHLHHAFVQADLGAGLAE
                     LGRGEAARAELLSALRLARACGAEPLARQVQGAWRSLREAGRGPWALPGAPRAAPDPAS
                     VAGSSVPPESAVHAAPHSASPLLDCLTPQERKILHLAKDGHSNRDIAGRLFVAVRTVEF
                     HLSGAYRKLGISGRRQLAQVFSGG"
     misc_feature    8123..8125
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     protocluster    9001..30941
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[19000:20941](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(19001..20941)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
     gene            complement(10001..11191)
                     /locus_tag="HEK616_RS18205"
                     /old_locus_tag="HEK616_37160"
     CDS             complement(10001..11191)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943480.1"
                     /locus_tag="HEK616_RS18205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37160"
                     /product="thiopeptide maturation pyridine synthase"
                     /protein_id="WP_261953989.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3e-78, bitscore:
                     262.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSAGASWYSLHVHHHDEAAEPELILGAVRPAFASVGTWVQGAW
                     FGRHWLRGPHLRLNFLTEASTWHAQVRPQVLEIVTDYLRARPSTVRLDSAALAPVHERL
                     AELEMETGPLRPWVADNTVVERPYDHRLHVLGSLRASELLAGFLSDTTDLAFRMYEQLR
                     TAPLPVLALDLMWTTAAAAAIPFEDGRAPIERGVLSLRSHADAFLSRTNDPVAYRARFD
                     ERFHRQEAALGARLREVEAALAEPEGIDPPPGSGMAFVGEWARAVRRHQRIAQPLLASG
                     EVSMGGAALAPRMPTRKTSEFHQLLLSDHGHRDFLVEDAWFASFRLVMNYLYLHLNRLG
                     LAPVDRGLLCHLASRTVESLHGTSASASFARYVAEPDGSEEPAWRRIGAEWAEGTR"
     gene            complement(11188..12219)
                     /locus_tag="HEK616_RS18210"
                     /old_locus_tag="HEK616_37170"
     CDS             complement(11188..12219)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677375.1"
                     /locus_tag="HEK616_RS18210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37170"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_261953990.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.3e-69, bitscore:
                     231.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMTNGLGDSARLDPAAAQAADWVCAHVFYDTDQDALLTRCVEPL
                     VTELEQRALIQRYFFLRYWEGGPHVRLRLLPSRARDRAGVAEVAERRLGAFLAESPAPD
                     VVDRSRFAQVAQGLAGLEGRAGHDGTVRANNTAEILPYEREHADYGRGPAIAAVERHFC
                     ESSRLALSVVSAGASVEQRALLAFDLVVGVFALCDEVRDRWARHGGPPLPFGSGPEAAD
                     VEPRYHAQREQLHARARRTWELAGRPPGNDQRGYWLASVRRLRDELHHMEETGQFVADW
                     ADSPLAEPLDLAATAHPATSLVLLRCAHLVNNRLGLTLWQENQLRFLVGRVLSELPEAQ
                     GVA"
     gene            complement(12216..14834)
                     /locus_tag="HEK616_RS18215"
                     /old_locus_tag="HEK616_37180"
     CDS             complement(12216..14834)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677374.1"
                     /locus_tag="HEK616_RS18215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37180"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_261953991.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-74, bitscore:
                     249.0, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEDFTTPDTFGVRIGGLPAPMLDDMRSPELWRQAESVRDLENQL
                     DGQASLLSDSLYEQIGRGGSAKPLLVAVRRAIHNRRPLTERHWNDALRTLLPRALVELV
                     DAWAQLRASHQEAVTRLDDLITHHICSQLVLLRKAASDPVLQHGLVLSSPVLLAEVRKW
                     LALPDERAPERSLALRLAKYLARVSMKTSPFSTFTASGLGTWSGVQGDRASTCPGVHTV
                     AELNVWVVQQVVRALGSRPELSGRARLRLNPSAVLTDGRWEFLGTGAEEPLRTLPVAAA
                     VRECVEVVREGRPTREEAARLLAERTGSDQATATAYLARLEELGLLEAEWPFADQTLDH
                     VAEVRSWLAGATSTELVGVERELAVIADTLVAYPHLADPAQRVRATGAVEQALRRIRDL
                     AGPDRISLPAKNSVIENALVGAPFPGPDRRAWGPVLRDLDAVRQCYAVLDPGLPGRVAI
                     ADLFAERVGPGEAVPFLTFHRLVQTWLREEPALPSLLSVAVHGYRAMHQHRLPRLGELA
                     ALRDELCEVVRAVPADAQGVVRVAPERLLSVVERRPAWMRAPDSVTYYGQPLGTGSAPE
                     FVVNAVNSGHGRGRDRIRRLLTQAGLDAVRDTAVDTAPSPPGLIHADTCRHFGSNVGLR
                     VSAVATEIEYPGGLSVRPPGHRIRLGDLLVRHDPGPGLLALHTRGRAGEVRPVHPNLIA
                     ELWLPPALRLQMQTFGATSNLLIPGRRMFGDPSLSEVREVLAEPRVVVGRTTVSRRQWV
                     LPPGAVPRREKGESDRSLLLRLVGWLAEHGMPQRCFVRALDPQSVVSGEVWRMKSRKPL
                     YVDFANLLLVGVFERLLAAGAGQVVFLQEALPGPGEMPDHDGSGPRVTEFLVEINEGRT
                     R"
     misc_feature    complement(12516..12518)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14893..16926)
                     /locus_tag="HEK616_RS18220"
                     /old_locus_tag="HEK616_37190"
     CDS             complement(14893..16926)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677373.1"
                     /locus_tag="HEK616_RS18220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37190"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_261953992.1"
                     /sec_met_domain="YcaO (E-value: 1e-74, bitscore: 250.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.8e-106, bitscore:
                     353.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDAATASRTGRLAETLRPAHPADPTTAPAAPAAPIAVVGKGVLA
                     STIRVALARTNRLVPEEDPACAAVVTAEDGWMTATEPPRPDVPWLPVRVELGLLVVGPT
                     TVPGRAGCARCARTRRQRTLGKDSPRAALMERHGDRLADRASPILTTWACETAAVLVES
                     ELRSTSSRLTDSALAFLSLTTMVIDVHRFLPDPACTWCGGIPEDRPPVLMERPRPKLAP
                     DVPRVRDLRADWEDVVARYVDGRTGLVRQLDVRTDYPYPMVSAPLHLPGGEQEAGFGRD
                     LDYGACARTALAEALERLGGAQPGGRRTTVRSGYAEIADRALCPVDLGLYPPERYAEPH
                     FPYPPYDPDLELNWVWGHSFARNAPVLVPEDYAYYRTRHGNPAARPLAYEVSNGCALGG
                     CLEEAALHGLVELAERDAFLLTWYARLPVPQVDLRTVSDPRIGALAERIRQDSGHRVLA
                     FATTPEHGIPTAWVMAISPSGPGRADEPAAVCAAGAHFDPEGALRNGLLELAANLGWNR
                     AAFREERERIAAMVDEPDLVREMRDHALLYCHPAAFDRFAFLLGDGGDAETGGRPVEEA
                     FAHATCRPRGTDIREDLAEAVARFTDRGLDVVVVDQTTNEHRAGGLACAKVIVPGLLPM
                     TFGHRMRRTHGLPRLLRLPSELGYRGDPLAEKDINPHPHPFP"
     misc_feature    complement(16996..17012)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.99"
                     /tool="antismash"
     gene            complement(17007..17189)
                     /locus_tag="HEK616_RS18225"
                     /old_locus_tag="HEK616_37200"
     CDS             complement(17007..17189)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677372.1"
                     /locus_tag="HEK616_RS18225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37200"
                     /product="hypothetical protein"
                     /protein_id="WP_261953993.1"
                     /transl_table=11
                     /translation="MQNELVLDLADLSADELEILPTSPGASLETVNVGHAMVEIGASNC
                     TSTGTPASCCSCCCC"
     CDS_motif       complement(17064..17189)
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MQNELVLDLADLSADELEILPTSPGASLETVNVGHAMVEIGA"
                     /locus_tag="HEK616_RS18225_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       complement(17007..17063)
                     /prepeptide="core"
                     /locus_tag="HEK616_RS18225_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type III"
                     /score="26.10"
                     /molecular_weight="1731.0"
                     /monoisotopic_mass="1729.5"
                     /core_sequence="SNCTSTGTPASCCSCCCC"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MQNELVLDLADLSADELEILPTSPGASLETVNVGHAMVEIG
                     A"
                     /leader_location="[17063:17189](-)"
                     /alternative_weights="1749.0"
                     /alternative_weights="1767.0"
                     /alternative_weights="1785.0"
                     /alternative_weights="1803.1"
                     /alternative_weights="1821.1"
                     /alternative_weights="1839.1"
                     /alternative_weights="1857.1"
     gene            complement(17380..19008)
                     /locus_tag="HEK616_RS18230"
                     /old_locus_tag="HEK616_37210"
     CDS             complement(17380..19008)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677371.1"
                     /locus_tag="HEK616_RS18230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37210"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_261953994.1"
                     /sec_met_domain="PF00881 (E-value: 9.9e-07, bitscore: 27.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSATVGQHGSVGLRFWWRTFEGVQDLFAEGHGEEGGPDDPLPVK
                     TYRELPRHVLPEPARRIGDARWSFEAFRDAHPQGIPTLDVLDQRALSALLYWTYGIGRI
                     ELGPHAVWPYHRMVASARCFHPVELYVWLARPAGELPAGCYHYNPAHHSVTLLREGGVP
                     HAVRIGAGVRAEAGLLVASAWFRKTAFRYRDYAYRLCAQEAGMTVGNALLTGAALGLRG
                     RVHYRFHDEVVNRALGLDGREETAFAVLDLAPAGEAAPAQARVASSQQPCLPCELPHIQ
                     PVHVQTDRTSDGTWSGLTALDLTARLAGPGAAVAPDDFRLPVEASGPDGVLGLAGPEPG
                     AGGMDLAAALRARDSGGRMFLPDARPVAFARLASALRYALEPVSSDHTEAPCRPLVGAY
                     VLVLGTDGASPGLYRLAAGMEPPALLRLPARDWRAVVGMLCDRTPAVNAAKAGAVVFLT
                     ADRLAGDRWFGARGYRVLHQEAGIVAQRVSVLAAAAGLSARITNGYHDGMVRDLIGLDA
                     AQVPVFTLIVGRRRPTAQYEPELIW"
     misc_feature    complement(18178..18180)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19001..20941)
                     /locus_tag="HEK616_RS18235"
                     /old_locus_tag="HEK616_37220"
     CDS             complement(19001..20941)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943462.1"
                     /locus_tag="HEK616_RS18235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37220"
                     /product="hypothetical protein"
                     /protein_id="WP_261953995.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 4.5e-18,
                     bitscore: 63.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     4.5e-07, bitscore: 28.3, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTGDGVHVFGAGADLALRGRSAYQWLDRLAPHLDGSVELDDLVG
                     RLPDDKRQVVHSLVGQLHAAGCLIDAEEELPHRLTRRELETYASEIAFIEYHCDSAARR
                     FETYRDSEVVVVGAGPVFVSLVCSALRSGVRQLRAVCTEKAVTNAERLAELTAEAAARD
                     PEQTFRHVACDKGGLERLVGQVGAVIHVADGSGVDRALRLDELCRNAGTLLVQGLVVDD
                     VAWLGPAGADWRSAWLRLDARRPFRPNAFLTGPAAAVVAAHLGLAAFTTLTGIVGAMDA
                     AHGARKVTRIDLETLRTSTHAFLLHPAAAPARPETRKEFRRRIERLGAAAPLDEDTFSR
                     RAARCFDPYIGVLRALDEREFTQVPLNVTEAVPRAEGEAPVHGAGTGFAAARRDAALRG
                     LASYAAHHPDERRYGPGGTVWGWALDERRAEAVAACRVFTTDHEVGVAARLSWDEGVAD
                     GLAQQCVRLALRDVAEGRSRPRPVRLRPDAMDPGERRLLDLLSASRGSVEVADIGEALG
                     VPVLAWWQGGRPAAATCGEDAVVEGLRAALLDRQSVMTGESAYAPARRGLLGAPVTCDD
                     SAELPVPAGPERMVEALRSRGARPLVVPLDHDPAVHEVLPFVVRVVIADEAGDEDGPAG
                     AVRRVEARGDA"
     aSDomain        complement(20702..20929)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HEK616_RS18235_Heterocycloanthracin_C
                     _RRE.1"
                     /evalue="1.70E-09"
                     /identifier="RREFam011.1"
                     /label="HEK616_RS18235"
                     /locus_tag="HEK616_RS18235"
                     /protein_end="80"
                     /protein_start="4"
                     /score="28.3"
                     /tool="antismash"
                     /translation="DGVHVFGAGADLALRGRSAYQWLDRLAPHLDGSVELDDLVGRLPD
                     DKRQVVHSLVGQLHAAGCLIDAEEELPHRLT"
     aSDomain        complement(20735..20938)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HEK616_RS18235_Thiopeptide_F_RRE.1"
                     /evalue="1.70E-20"
                     /identifier="RREFam004.1"
                     /label="HEK616_RS18235"
                     /locus_tag="HEK616_RS18235"
                     /protein_end="69"
                     /protein_start="1"
                     /score="63.8"
                     /tool="antismash"
                     /translation="PTGDGVHVFGAGADLALRGRSAYQWLDRLAPHLDGSVELDDLVGR
                     LPDDKRQVVHSLVGQLHAAGCLI"
     misc_feature    complement(21314..21327)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.4"
                     /tool="antismash"
     misc_feature    complement(21500..21513)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.23"
                     /tool="antismash"
     gene            21632..21784
                     /locus_tag="HEK616_RS18245"
     CDS             21632..21784
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_261957580.1"
                     /transl_table=11
                     /translation="MRSVLWQCGIGIDLPPAPDLDSHDFDQLLVHAEGVWKPGGPGPPR
                     PHRHP"
     gene            complement(22008..23201)
                     /locus_tag="HEK616_RS18250"
                     /old_locus_tag="HEK616_37230"
     CDS             complement(22008..23201)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969831.1"
                     /locus_tag="HEK616_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37230"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_261953996.1"
                     /transl_table=11
                     /translation="MDPADSATGTVSAGRSTGTRLPPGDFGVVLATLRARRGWSVREFA
                     RRANVSEGQICNLESGLRNPTPAVAAACDAAFGTGGELVELAGAGRRGARTEGIVEAGP
                     VVAGYERVLWELKGIGRSTGPRFVTASMKSITRILTDAGPHAVGEQRAEIWRLASRFAE
                     YTGWMAQEAGNPAEALRWTNLAVRWGALGGDETVAAYALVRKAFIAQHRGDTHAAIGFA
                     DQAAGHPAANPVIRAHAARRAAQGHACRGDAGACREALERFRGYAAEVTGDRTPHWGPR
                     IENGNPRLIEASCMLSLRRFELAADLFAAERRRRPAVPADDNSQARFAVRQATALAGVG
                     RLDDACQIVEATLPVIKRIDSATLRAELGPFVEQARTRRASPGQLALIDASTALAIG"
     gene            23323..23940
                     /locus_tag="HEK616_RS18255"
                     /old_locus_tag="HEK616_37240"
     CDS             23323..23940
                     /GO_function="GO:0003953 - NAD+ nucleosidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969832.1"
                     /locus_tag="HEK616_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37240"
                     /product="toll/interleukin-1 receptor domain-containing
                     protein"
                     /protein_id="WP_261953997.1"
                     /transl_table=11
                     /translation="MVPRIFLSFRKPDSRWMRDRVYRALSDRLGAHEIFKSGQSIPPGA
                     DFAEILRRQAAECELMCVLIGPRWLDARDEDGVRLLDRAHDWVRLEIATALRAGNRVVP
                     VLLGDATMLPGASALPADIAELARLQFLRVPETHLPDGLEHLGDAVTALLSDTDTDTDP
                     AVEPGHSTAPAADPEPSMTMTAHVSGGGSAYQAARDQTIRLA"
     misc_feature    23407..23409
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            24083..26176
                     /locus_tag="HEK616_RS18260"
                     /old_locus_tag="HEK616_37250"
     CDS             24083..26176
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019055431.1"
                     /locus_tag="HEK616_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37250"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_261953998.1"
                     /transl_table=11
                     /translation="MAPELAADPGFRDRFRAAVEAARTLSGAFLVPVVDADADAPVPWL
                     ATEFTAGVPLRQAVDRHGPLSEPALRVLADGLAQALATLHAAGTVHGEVSPDSVLLTMD
                     GPRITALGIVGATGSPAPSPTDDMFDLGSTVLFAASGGEPDTGALAVSLREVIGGCLYP
                     EPQDRPTAEQLVDYLRRQDLPALSGSWLPPAVTADMAAAAAAVGSVSAGDGGQGPFPPP
                     PVIPPGTGISRRKLIVGLAGGAAVLGGAAAALAFSGDSSPAPDGRAGGPGSTARPTSPS
                     GVRSTPASSASPSSTDGPESIVLAGPDAAKAWSGAGKHAPNCLEASDKVVMVVTNTGTS
                     FLDAATGKSMFPELNTTSFLGTTSLTYPTAYADGVFYLLCDTPSQSGMLAAFDAASGKV
                     KWATKMADVDPGGGTHAARYLSNYVAVAGNTVYVCGQMSRTSGSFSPESPTTGYIRAFN
                     AATGKGLWRVKGTDINNVLVPPSGSHLLATSAVPGKKPGRVQMIDAGKKGARGWKVSVP
                     HAGYYFTTGWPLTCYAAGLFLFAGGNGDTLFAVDATTGSEKWHRRFDAKSGDQVQIGAP
                     FAGLDGATVYVPVGSDLAALASADGTLQWVATLGGASDMGGSNMFKAALRTSGKSAQCS
                     ADTVFATDSAKTLWAIDAATGRARWKYSDPGQPDVGFLWTVGGDHVFIASHLTVTAIAA
                     HGR"
     gene            26193..26624
                     /locus_tag="HEK616_RS18265"
                     /old_locus_tag="HEK616_37260"
     CDS             26193..26624
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019055430.1"
                     /locus_tag="HEK616_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37260"
                     /product="hypothetical protein"
                     /protein_id="WP_261953999.1"
                     /transl_table=11
                     /translation="METSVELAGLASAAAARLIDLLTTDGWAAVKSSVLSLWRSAHPER
                     IEEELADARGELLQAQQTGDGQELQGLLVAEWQARIIRLMATRPDAVAELRTLFGAELR
                     PAGAPEQQISGSMTLEAHVSGGDAFLAGRDMNVTRGGQA"
     gene            26621..30514
                     /locus_tag="HEK616_RS18270"
                     /old_locus_tag="HEK616_37270"
     CDS             26621..30514
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.2"
                     /locus_tag="HEK616_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_37270"
                     /product="AAA family ATPase"
                     /protein_id="WP_261954000.1"
                     /transl_table=11
                     /translation="MTERSTGAPSPDGPPLWQPKRQEASATGGGSVFQAGRDLHVRVGD
                     EGRRTVPGPGADQVPCPYPGLAPFGARHKQWFYGRERMVHLVCERMDARMREGGPLVLI
                     GPSGAGKSSLLAAGVLPALDDGRLPAAGSSTWPRLLLTPTASPALALAAAARLDAETAR
                     RTAPAWRADPARCLAELREITGAGDPAPTGESPSAGLVVVVDQFEEIFTACGDETERQW
                     FIDVLDRLARPAGGAVVVLGVRADFYAACTAHPQLRAALQAGPVLLEPMTEDELKDAIR
                     RPAGNVGLDVEDGLVEVLLADLGAVGGPVGTSTTGRLPLLAHALRATWQQRHGHTLTVD
                     GYRVTGGIQGAIANTADRLYDTLPPPCHEAARWVFLRLVIVGRDADDSRRRVRYDELLR
                     HAPDREAAVRVLDDFTRGRLLTRDQDTMVMTHEVLIRAWPRLRGWIEHDRSGNLVRQDL
                     EEAAELWEQADREAAALYRGNRLEAALAWAETHGPELSGAARAFLAAARHHQRRGQRLR
                     RAAVATITALAVIASLAAVFAFRQESNARKAATQALRARDQAINAAVTSASVQLAPTDP
                     SLSAQLALTAYRMDPTPKAASRLITTENTPLDTRLPGPRGAVYTVAYSPDGHMLAAGNV
                     HQRLVRLWDVSDPSRPVALGRPVPVDRSVDSILSLAFSPDGRVLAVGGHTSHNGDAGSG
                     GFVDLWSLTSPSHPVLLGRPKSPGIQGLDAATSIESLAFSPDGRTLAAGWHAGFVSLWN
                     VSRPDDVKPAGAPLNLDCPGVFSGRIAFSPTGHTLAAACDDDAGTIRLWNTTDPAHPGR
                     GRSLKAGHRVISLAFSPDSRTLAAGIEDSTVHLWKVADPSHPTPLGKPLTGPAQPVMSV
                     VFSPDGHTLAAGSADHTIHLWNVTHSRAIGPLGRPLTGPGDAVTDVVFSPDSRTLAAGN
                     TDGNVDLWNLPPTRIIGAGGNVASVAFSPDGRTLAAGNQNNTVSLWNTADPNHPAPRGD
                     PLTGPKEPVDAVAFSPNGRTLAAGDSGGTVTLWNTADPSHPVRLRKTLSGADGTIFSLA
                     FSPDGHTLAAAGDNHDRGSIALWDVSDPAHPDAQPGISNDHTRSVESLAFSRDGTMLAA
                     GGDGSNHEVGLWSTTDPGVRIGEPIDQPNATSTWVAFSPDGRTLATGNSRGTVTLWNAT
                     DPHHLTRRGSPLTVPGGSLWSVAFSPDGHTLAAAGHTDDGTITLWNVTDPDRPTLIGRP
                     LTVETGFAAVLAFSPDGHTLAATTDDGVATLWDLNVKSAISRICAGSSGALSRQQWSRY
                     VPQLPYDPPCVTT"
ORIGIN
        1 cgtgatgtca cggaaggacg agatgaagca cgtaagcact gatccgccac ccatcatccc
       61 ggcacggccg ggtgagaacc gcctctggga atgggcccgg gaacaattcg atctggaccc
      121 tggctatgtg cacctggcgc tgtcgatgct ggcccctcac cccaggacgg tacgtgaggc
      181 cattgcatac catcgcaccg aattggaccg aaaccctgcc ctccacttcc atcagcggga
      241 cgagcgcgtc cggcgggtgc tggcaacggc cggtgcctac ctcggcgcgg atccggactc
      301 gatcgcgctc accgaaagca ccaccgccgg catggctgtg gtctacaccg gcatgcggct
      361 cgggcccgag gacgagatcc tgagtacccg ccacgagcac tacgcggctt cggagcttct
      421 acgcttcaag gcgaagtcga gcggcgccgg ccaccggtgc atcagcctgt acgaggacgg
      481 accgacggct acgagtgagg agatcgtctc ctccctcgtc cgcgaaatac gggacaacac
      541 ccgtctcctc gcccttacct gggtgcactc gggtaccggg gtcaaactgc cgctttcccg
      601 cataggcgag gcggtggccg aggtgaacca cggccgccct accgaccgtc agatcctcat
      661 ctgcgtggac gccgtccacg gcttcggggt agaggacttc accgtcgagg aacttcgctg
      721 cgacttcttc atggcgggct gccacaaatg gctgttcggg ccacgcggta cgggtgtggt
      781 gtgggggagc gagagaggat ggaacgcggt cgaacccatc atgacctcgt tcgacgtcga
      841 ggtgttctgg ccgtggtacc tgggccgtac ccccgacgcg gaagcccccc gcgcccggct
      901 gtgcactccc ggaggattcc ctgttttcga acaccgttgg gctctggcgg aggccttcga
      961 cttccagctc accctgggca agaagcccgt agcgatgcgc atcgccgatc tcaatgccta
     1021 ctgccaccgg cgactcatgg agacagccgg tatcaccgtg cgtaccccgg cggacagagc
     1081 gctgcggtcg ggcatgacct gcttcgacgt cgagggccgg gaccccggag agatcgctgc
     1141 catgttggag aagcggcgga tcatggcagg tcaaactccc taccgagaca gcgcagtgcg
     1201 cttcgctccc ggcatcctca actcggtggc cgacattgac cgcgccgtgg aaacgttgga
     1261 acagatcgtc cgtgcagggc cgcaggagcc cccagcatga atacggtggg tccgcttgtc
     1321 gcagagagac cccttccgga ctgcgcaggc agggcatagc gccggtgcgt tggactccgc
     1381 gccggatcct ggccgaggaa cagcaatggc gtgccgcccg aggccgagct gcggacggca
     1441 gggcgcccgc gccggagggg aggatgtgct ggagccgacc gcgctcgccc cggtcaatcg
     1501 gcagctgcgc agggcgttcg aggacggcaa gaacgagccg gacgccgctg ttgccgttgc
     1561 tagccaacga gggcttgggc gatttgccgg gtggtctgcg tagtcggccg tcactactgg
     1621 ttacgacagc aggactcgtt tccggaggag ttgtaagcca gcccggccga acatttggcg
     1681 cttgagcatc ttgatccggt tgacgtgccc ctcgaccacg cccgagttcc agggcagcgt
     1741 cagaccggcg attacagcgt cgcggtcacg gtcgatgccc gttgcgaggg tgtcaaggct
     1801 cggcaggtcg tcctgacgga cggcgtcggg ccattccagg agtcgttcgc cccggcgctc
     1861 ggtgagcatg tgtgcgaagg gccggacgtg gcctgtgagg gcgtcgagct cggcacagtt
     1921 gggcaggacg gctttgagcc ggagttgttc gatctcggtg agggattccg ggcggctgag
     1981 aatccatcgg gttaccacgc gaggtgccgg gggctgtgcg gtgattggcc ggggtgacgt
     2041 gcgcttcttc cggatgtagg cgctgacaat gccgtagctg cccttgtagc cgagcgggac
     2101 aatctcctcc cagagcttcc agacgcacgt gcagccctcg ctccaacgct cgtccaggta
     2161 gggcttgtac tcgtcgaggg cggaggtccg gctgtactgc cactgcctgc gaaagaggtc
     2221 ctccggtctc gcggcatcgg tgaggctttt gacggtgcgg tgggtcatgc ggagttgccg
     2281 gccgatggag cggcggctgt ggccagcttc gagcatcgcg tggacggtgg cgtgcctggc
     2341 ccggatgcgg ttggcgaacc ggtcgcccct ccagggcgat tccgggatct cgtcaaaggg
     2401 ttcggttgtg tcgacctcct ccttgaccgg ttcggggagg aggacgcgga ggcactggcg
     2461 gtggcgggcg acttcacgct cggcggcctg gccgaggttg tgccacagat gccaccggtc
     2521 agcgacctgg accgcttggg gtgcaccggc tgtggcgcct tccgcgaaga atggggcccg
     2581 gtcccggcag acgacctcga tgccaggccg cttcgccagc cactgagcca ggctggacgc
     2641 ctcccggtcc ggcagcagat cgatgggacg gcgagtctca acgtcgacca gcaccgtgcc
     2701 atagacgcgg cccttgccgt ttgcgtactc atcgacgcca tccgcccgcg gggacggggc
     2761 gtcaggttcg ggcaaggccg cgagcagccg cagcacggtg ctgcggctga cggatacccc
     2821 gaagaccttg gccgtccgtg ccccggcccg gcctgccagc gctaggccga ccgcggccag
     2881 tgctgaccgc agcctttcgg cccatcgacc gtgccgtcgg gtcagccccg gaatctgctc
     2941 agcggatgtc cgtcgtccgc acgaagggtc cggacagaag aaccggcgga ttcgcacgca
     3001 cagaagcccc tttcggctgg cgctgggaac gtcggcggga aaccgctggt aggagctgtg
     3061 tggcccactc gatcgactcc cacagtcagg gcagttcgcc ccggttgccg tgctgcaaac
     3121 ctcaatgcgt atcgcctctt cgtccatgcc caccgacagc acagcgacat ccgcgatcga
     3181 tgggaacaac agctcctcca gccggaacac cgtcttctcc acgaccccgg actgtcgacc
     3241 acaccaagat catcacggat cattttgagg caaccccgag cagaccctcc cggccgtcaa
     3301 ccgtcacact ccgtatgcga aagttgagcc acaaccacta ttgctcgata aagccatcgg
     3361 tacgacgcga tttccgtcgt cggggtcctt ccttcatcgg cgtcctggcc gcagagggtg
     3421 aatgaggagc aggggaagac gggggttacg gattgggttc cggtgagctg tcgacttcgc
     3481 cgtgcgcggt ccaggtcttg agcacatgct cgcgccatcg gccctttcga cgaggcggat
     3541 gattgcgttc tcccgggtgc catacagccc gacccaactg ccataggtgc gcagggcggt
     3601 ggcgtcggcg gtccactcgc cggtgacggc agggggttct ctggggttga gaggtgccgc
     3661 gaaccaggtt ggtgcagctc agcagtggtg tggttgagcg caatcagtgc aaaggtgtgg
     3721 tgccaccgct gattcgagcg aaccggctcg cccgtaacgg ccccggactc ctgtctctgc
     3781 tgagaacctg atactcctcg cctgtgggcg aaagcagggt ggacacgaga caggggcggg
     3841 ccgttggata cgggcgactt gatttctgct gtcagcgcac ttgttgccgc tattgcggcg
     3901 ggggtgggct ggtggcaagc acacagcgcc agacgcgctg tcaaggcggc cgaggaacag
     3961 gccaacgcga tgcgcgacca agtcaaggcg gccgaggaac aggtcagtgt gatgcgcgac
     4021 caaatcgtgc tggagcacat gaggccccgc tttgaagtca cccacgctac gacgatgctg
     4081 ctcccccgcg gcggagggcg actggtaatt gaggttgcgc agctcaccgg tgtgccactc
     4141 gatgacgtga aggtggagct gcatgtcggc agcagacagg tcatgaccga tggggcgcac
     4201 gacggcgtcc acacctgcct gtactccgcg cccggcagta agctcacctt tcgcgctcac
     4261 ctcgacgtag aggccgcgca ggccccggct gtccgcgtcg aactgtccgg cacagaggcc
     4321 caaggcacac ggcagtgggc tgaaagactc atcgctcatc cggttctcac ggacaacaga
     4381 ctgctcactg aggggcggac cgctgccgga ctgccccggc gtgcttcaag cagccgcgac
     4441 tactccgtga acgacgagcg gtggcggcag gccccgcagg tctcccgcgc ccctggcgac
     4501 gtacggggca ggctggccaa tctgcgccgg ggtatccagc agggtcgcag tgtgggaagc
     4561 aaaacgaaag gtcaggggtc cggtcctgac aacgcctcaa ggcaggatgc gagacctggt
     4621 gggaccacgt cggggggcgt ggccccggat gccgccggca acgacaccga ccctgaagat
     4681 gattcgagcc gttgatcgca ttccctctcc gtgacgtcct ctgagactgg aaggctcctt
     4741 gagcgccttc gtcgtcagct ccgcccggtc ccgcccgaac cgaagattcc gaagccaccg
     4801 gtcagcgacc gggacgacct ccagatcgtc gtcgagaacc gtccagtatt tctgcccgga
     4861 cggcaacacc acgggaaacg cccgcattcc aagctcctgc cacgagttgt gcaacaaccc
     4921 gccgcggccc cccgagaacg agccccaggg cctcaacgaa cccgcctcat accaagtcac
     4981 accgcacgca tcccaccccc agagaacggg ccgccctcct cgaattggag gagcgcgagg
     5041 tactgggtgg tcaccgggcg ggctcctgtt gatccgccgt acgcgagcac cagacgtgac
     5101 gttgatacgc cgcggcaagg agggccggtg gctgcgccgt ttgataaccc ctgcacggac
     5161 gaaggccaag gccttgagtc tgcgcacccc gcgccgctgg gcattaggtc ccgtcagcag
     5221 ccccctttga ccgcgcggac gctgacggag ttgattgcgc acctcgacca gtccagatcg
     5281 ccagcggctc cgagttcatc gaggatgacg cggtgcagtc gggcccagac acgctccttg
     5341 gaccactggg cgaagcgtcg gtagacggtg ggccaggccg gcccgaacac aggaggcagc
     5401 tgccgccagg agcagccgga ggtagcgacg aagatgatcg ctgccaaaca ctcatgatct
     5461 ccagctcgcc gacgcccacc accctgcggg cgtgtgacca ccgtctccgg caccactcgc
     5521 cgaaacagca cccacaactc ttcagacgca atccgctcag caaagccggt catgctcaga
     5581 ccaacgagtc acatcgccga acgaaacgag tcggagccag gggcggtggg aactcaggtg
     5641 cggcatcgca cgggcatcgc gcaggatggc cggcgtgata ctgaccttcc cgtgcgtgtg
     5701 ctgcggccat ctgaccctgg gcgagccgcc cggctcctat gagatctgcc cggtgtgctt
     5761 ctgggaggac gatcgcgtgc agttgcgctg gcccaactgg gccggcggcg ccaaccggcc
     5821 ttcactgatt gaggctcagg cgaactttat ggagttcggg gcgtgcgagg aacggttcgt
     5881 gaccaaggtc cgcctgcccc gggatgacga gccgctggat ccgaactggc gccccatcga
     5941 tccggagcag gaccacttcg agccccgggg cacacaggag gcgccgtggc ccgacgactg
     6001 cacggtgctg tactggtggc gttatcgcga caccggatcc tggcctcgtg gcggttgaga
     6061 tgagctggct tgctcgtcga gacaggtccg gctcaaccgc cgtaataagc gcacgccgga
     6121 aagcttcctt gcactcgcag ccatagccac cagcctgatc agcaaccgaa gactcaccaa
     6181 gtgaaacgac gtctcactca cgactcggcg agcaagccct cccgcagcct ttgcaggccc
     6241 ggttcaacag ccgggagatg tgcatctggg agaggttgag ctccttgccg atgtcggctt
     6301 gcgtcatctc cgccccgaac ctgagctgga gcagcttacg ttcgcgctcg acgactggct
     6361 ggctccgcgg gtggcgaagg cccgctcaac cctcgaagcg gggcgctgcc ggcgtttctc
     6421 gcagatcttg ccaccgccgc gcccgcgctc ggacgcccca ccgggcacat caccagcctc
     6481 cccatgcgtc cctccgcact caccctgcgc acgtcccccg aggtcctcac tgcggccttg
     6541 ccgcaactca gccaggccgg tctgctcacg tacacctatg acggcgactc ggatgcccca
     6601 tatgccacga ccacccagct ccctggcggc gcgtcccgcc cggcgtgccg cgcgacgcta
     6661 tccagccctt cctcggcttc tcagggctct ttgctgtggc gctgaaggtg cccagtcgcg
     6721 agacgccctc aagacccgtt ggcaacggct gaaatgacgc catgggtgta tcgggtgggc
     6781 ttgtcgctca gaacgcgtgc tgcgcatgct cttgctgcag gagagcgctc ccaaggggga
     6841 gttcgcgtta tgggggcggt gtcggggttg cgtggctggt gcggtgagac ggcgccttga
     6901 ccgtcgtggt ggccggtgtc gcgtgcggcg ctggactgta tgcgccgagc tgtctgtcag
     6961 gagcctggct gcatcgcaac atctggccat aaggggtctt tttcaagacg actgcctaaa
     7021 tacgcacttc acgcgaattc cgtgaccagt gaactgattg tcggctctgt gcgtagagcg
     7081 gtgcacgacg gtcggcgatc gggaggggct catggcgctc ggggagatcg gccgcaggag
     7141 cgagaaggcg cggctccggg ccgtgctcga agagtcccgc agggaccgag gccccgtcgt
     7201 agcggtcgtt cgtggcgagc cgggagcggg gaagtcgacg ctgctcgacg ttttcggagc
     7261 ggaagcgtcc gcggcagggt tccgcgtcgc cacggtgcgc gggacgggag cggaggaccg
     7321 tccgtacgcg gcagccaacc ggctcatcgc ccaactacga gccggcggtg ggaaactcgt
     7381 ggagatccag caccggacac cgcccggcga tggtcccggg gggctgatcg ccgccgtgcc
     7441 gacggaacgg gacgtcccgg tcgctctctg cgtggacaac atggctcagg tcgacagctg
     7501 gtcactgcgg tggttgctgg atctttcccg gacgttgccg cccgcgccgc tggcgatcgt
     7561 gctcacggtc aggatctggg gcgccggggt cgaggccgtt tccggccctg tggatggggc
     7621 ctggggcgag cccggcaccg cgctcctcgc cgctgccgag ctcattgacc tcccggggct
     7681 gctgacgatc gatctgcccg aagctgccgc cgcacgatgc cgcgtccgcc tcgacacacg
     7741 caccgccgcg gtgtgcggtg agctcaccgg cggcaacccc gccctcctgc acgccctgct
     7801 ggcgccgcac accggcagcg ctcccacggc cgacgcgctg cgcaccaccg ccgcgtcggg
     7861 cgcgctggca ggagctgacc ggtggctggc gccgctgagc gcctcggccc tggccctggc
     7921 gcgggccgtt gctgtgctcg gcggcggcgc tgaggtcgtg gacagcgccg agttggcccg
     7981 gctgacggtc gaggaggcgc tcggtgccgt tgaccagctc gtcgacgcct gcctcctcgc
     8041 caatcacacc ccgctggcgt tccgtcatcc actcctcgaa accatggttc tcggccgaat
     8101 cgccgccggc acccggaccg ccttacatct gcgggcggcg gccctcctac gtgaccggca
     8161 ggcggctacg acgactgtcg ctcaccacct ggtcgccgcc ggcccagtgg gagaggagtg
     8221 ggcgatgcgt tgtctgtggc tggccgcacg ccagctggag cagaagggca ggccccagga
     8281 cgcggcccgc tgcctgcgcg cagccctccg cgaacccctg cgcccccatg aaaagttggc
     8341 cgtgcggcgg gaactcgccg agctggacgc ctttgtcgac ccggagcgcg ccgtacgcct
     8401 cctggacgca gcgcgctgcg agtcccagga ccccggcgtc gtactcgaat acgcgctggc
     8461 actggccgcc gtactggccg agtgcggccg ggccgaggac gccgtcaccg tgctcgacga
     8521 tgccgcggcc cgcctcgggc ggacaccggg ggacggttcc tggcagctgc ggttgcgtct
     8581 gcacaaggcg ttcgcctgcc gtcgtggtcc cctgtggctg gcgcaggctg cggatccgct
     8641 gggcaacctg acctgccgga ccccgcaccg cgggaacgcg ggccgcgagc tcgcggcgct
     8701 gcgcgcggta caagcagtcg acgccggggc cgaccggggg gcggccgtcc ggtacgcccg
     8761 gcagggcctg ccccgggctg agggggatgg ctcggccacc ctggtgtggc gcacctgcgg
     8821 tgcacttgtg gcggccggcg aagtagccga agcgtggacg cactgcggcc gcgggcgcca
     8881 ggttgtcggc gcccgccctg gccgctggga ccacataaag gtcgagctgc tgcgcgcggc
     8941 ggtcctgcgg gcccgggggg acctccacgg cgccgacacc accctgaccc ccatggccga
     9001 ccacctgctc gccttcgcag ccaccggtca cccctcggcc gtgaccggcg tggccgctct
     9061 ggtcgaggtg cacgtcctga agggcctggt cgactcagcg cgttccctgc tggccgagag
     9121 cggcctggac cggggcccgc tgccgtggcg gcgggactcg gcgtacgccc tggccgcgcg
     9181 agcggcggtc cacgagagcg acgaccccgc ccgcgccctg gaggacctgc ttgcggcagg
     9241 tcgcctcctg gaggaggtgg gggtgcggaa ccccgcggtg ctgccctggc gctcccgagc
     9301 tgctcggctc ctagcggcgc ggggtgaacg caaggaggcc gccgaactcg caggcgccga
     9361 ggcggcggac gcccgccgct ggggcacacc ggagtccatc ggtaccgcat tgcacgcact
     9421 ggccctcacc gagtccgggg agcggcgcat cgacctgctg acggatgcgg ccgggatgct
     9481 cgcccgctcc tcggaccacc tgcaccatgc cttcgtgcaa gcagacttgg gagccgggct
     9541 tgccgagctc ggccgcgggg aggcggcccg tgccgagttg ctctcggccc tccggctcgc
     9601 ccgcgcgtgc ggcgcggagc cgctggcacg gcaggtccaa ggcgcctgga ggtcgctccg
     9661 ggaggcgggc cggggaccat gggcgctccc cggggccccc agagccgcgc ccgatcctgc
     9721 gagcgtggcg gggtcgtccg tacccccgga gtccgccgtt cacgccgccc cgcactccgc
     9781 ctctccgctc ctggactgcc tgacgcctca ggaacggaag atcctccacc tcgccaaaga
     9841 cggacactcc aaccgcgaca tcgcgggccg gctgttcgtc gccgtacgca ccgtcgagtt
     9901 ccacctgtcc ggtgcgtacc gcaagctggg catcagcggc cgccgacagc tcgctcaggt
     9961 cttcagcggc ggctgacgcc tgggcaggcc ggggcggggc tcagcgcgtg ccctccgccc
    10021 actcggcgcc gatccgccgc caggcgggct cctcgctccc gtcgggttcg gcgacgtacc
    10081 gggcgaagct ggcggacgcc gacgtgccgt gcaacgactc cacggtccgc gacgccagat
    10141 ggcacagcag cccgcggtcc acgggcgcca gccccagccg gttgaggtga aggtagaggt
    10201 agttcatcac caggcggaac gacgcgaacc atgcgtcctc gacgaggaag tcccggtgcc
    10261 cgtggtcgga gagcaggagc tggtggaatt cgctggtctt gcgtgtcggc atgcgcggcg
    10321 ccagcgccgc cccgcccatc gacacctcgc ccgaagcgag cagcggctgc gcgatccgtt
    10381 ggtgccggcg cacggctcgc gcccactccc ctacgaatgc catccccgag cccggcgggg
    10441 gatcgatgcc ctccggctcc gcgagtgccg cttccacctc ccgcaaccgt gcgccaaggg
    10501 cagcttcctg ccggtggaac cgctcgtcga agcgggcgcg gtaggccacc ggatcgttgg
    10561 tgcgggacag gaaggcgtcc gcgtgcgaac gcagggacag cacgccccgc tcgatcgggg
    10621 ctctgccgtc ctcgaacggg atcgccgccg cggccgccgt ggtccacatc aggtccaggg
    10681 ccaatacggg cagcggggcg gtgcgcagct gctcgtacat ccggaacgcg aggtcggtgg
    10741 tgtcggagag aaacccggcc agcagttcgc tcgctcggag cgagccgagt acgtgcagcc
    10801 ggtggtcgta cggacgctcc acgacggtgt tgtccgccac ccagggacgg agcggcccgg
    10861 tctccatctc cagttcggcg agccgctcgt gaacgggcgc gagtgcggcg gagtccaagc
    10921 ggacggtgga agggcgagcc cgcaggtagt ccgtgacgat ttccaacacc tgggggcgca
    10981 cctgcgcatg ccatgttgac gcctctgtaa ggaagttgag gcgcagatgc ggtccacgca
    11041 gccagtgccg gccgaaccag gcgccctgca cccaggtgcc caccgaggcg aacgccggcc
    11101 ggacggcccc caggatcagc tccggctccg ctgcttcgtc atggtggtgg acatgcaggc
    11161 tgtaccagga cgccccggcg gatccggtca tgcgacgccc tgcgcctcgg gcagctcgga
    11221 cagcacccgc cccacgagga accgcagctg gttctcctgc cacagagtga gtccgagccg
    11281 gttgttcacc agatgggcgc agcgcaaaag caccagactg gtggccgggt gggcggtggc
    11341 cgccaggtcc agaggctctg ccagagggga gtccgcccag tcggcgacga actggccggt
    11401 ctcctccatg tgatgcagct cgtcgcgcag tcgccgtacc gaagccagcc agtatccgcg
    11461 ctggtcgttc ccgggtgggc ggcccgcgag ctcccaggtg cgccgggccc gcgcgtgcag
    11521 ctgctcccgc tgggcgtggt agcgcggttc gacatcggcc gcttcggggc cgctcccgaa
    11581 tggcagcggc ggcccaccat ggcgcgccca ccggtcgcgg acctcgtcgc acagcgcgaa
    11641 cacgcccacc accaggtcga acgcgagcag cgcccgctgc tccaccgagg cgcccgccga
    11701 caccaccgac agtgccagcc ggctggactc gcagaagtgc cgctccacgg cggcgatggc
    11761 gggcccgcgg ccgtagtcgg cgtgctcacg ttcgtacggc aaaatctccg ccgtgttatt
    11821 ggcccgcacc gtgccgtcat ggcccgcacg gccctccaac cctgccagtc cctgcgcgac
    11881 ttgtgcgaag cgggagcggt ccacgacgtc cggggcgggc gactccgcga gaaaagcgcc
    11941 gaggcgacgc tctgccacct ccgccacgcc ggcgcggtca cgggcacggg aggggagcag
    12001 ccgcaggcgc acatgggggc cgccctccca gtagcgcagg aagaagtacc gctggatcag
    12061 tgcgcgttgc tccagctcgg tcaccaacgg ttcgacgcac cgtgtcagca gcgcgtcctg
    12121 gtcggtgtcg tagaagacgt gcgcgcacac ccagtccgct gcctgtgcgg ccgccgggtc
    12181 caggcgggcg ctgtcgccga gcccgttcgt catggtcatc gtgtccgtcc ttcgttgatc
    12241 tcgacgagga attcggtcac ccggggcccg ctgccgtcgt gatccggcat ctcgccgggg
    12301 ccgggcaggg cctcctggag gaacaccacc tggcccgcac cggcggcgag cagccgctcg
    12361 aagaccccga cgagcaacag gttggcgaag tccacgtaca acggcttgcg cgacttcatc
    12421 cgccacacct ccccactgac caccgactgc gggtccagtg cgcggacaaa gcaccgctgc
    12481 ggcatcccgt gctccgccag ccacccgacc agccgtaaga ggagagaacg gtcgctctcg
    12541 cccttctccc gcctcggcac ggcgcccggc ggcagcaccc actgccggcg gctgaccgtc
    12601 gtacggccca cgaccacccg cggttccgcc aggacctccc gcacctcgga gagcgacggg
    12661 tcgccgaaca tccgccgccc cgggatcagc aggttggatg tcgcaccgaa ggtctgcatc
    12721 tgcaggcgca gcgcgggcgg caaccacagc tccgcgatca ggttggggtg gacgggccgt
    12781 acctcaccgg cgcgcccccg cgtgtgcagg gcgagcaggc cggggccggg gtcgtgccga
    12841 acgagcaggt cacccaggcg gatacggtgc ccggggggcc gcacgctcaa ccctccgggg
    12901 tactcgatct ccgtggcgac ggcggacacc cgcagcccga cgttgctgcc gaagtgacgg
    12961 caggtgtcgg catggatgag gcccgggggc gagggagcgg tgtccacggc cgtgtcccgt
    13021 accgcgtcga gccccgcctg ggtgaggagt cgccggatgc ggtcccgacc ccggccgtgc
    13081 ccggagttga cggcgttgac cacgaattcg ggcgcggagc cggtgccgag cggctggccg
    13141 taataggtca ccgagtccgg cgcccgcatc catgcgggcc tgcgctccac caccgagagc
    13201 agccgctcgg gggcgacccg gacgacgccc tgcgcatcgg ccggaaccgc gcggaccacc
    13261 tcacacagtt cgtcccgcag cgcggcaagt tcgcccagcc ggggcagccg gtgctggtgc
    13321 atcgcccggt aaccatggac cgcgactgag agcagtgagg gcaacgcggg ctcctcgcgc
    13381 agccacgtct ggaccagtcg gtgaaaggtg aggaatggca ccgcctcgcc ggggccgacg
    13441 cgctcggcga acagatcggc gatcgcgacc cgtccgggca ggccggggtc gagtacggcg
    13501 taacactgcc gcacggcatc caggtcgcgc aggaccggcc cccaagcgcg gcgatccggt
    13561 ccggggaagg gcgctcccac cagggcgttt tcgatgacgc tgttcttggc gggcagactg
    13621 atccggtccg gaccggccaa gtccctgatc cgccgcagtg cctgctcgac ggcgccggtg
    13681 gcgcgcaccc gctgcgccgg atcggccagg tggggatagg cgaccagggt gtccgcgatg
    13741 acggcgagtt cccgctcgac cccgacgagc tcagtacttg tcgccccggc gagccaggag
    13801 cgcacctcgg cgacatggtc gagggtctgg tcggcgaagg gccactcggc ctccagcagt
    13861 cccagctcct ccaggcgcgc caggtacgcc gtggccgtgg cttggtcgct cccggtgcgc
    13921 tccgcgagga ggcgagccgc ctcctcgcgt gtggggcggc cctcgcgcac cacctccacg
    13981 cactcccgca ccgcagccgc cacgggcagg gtgcgcagcg gttcctcggc tcccgtcccc
    14041 aggaactccc agcggccgtc ggtgagtacg gcactcgggt tgaggcgcag ccgcgcgcgc
    14101 ccggagagct cggggcggct gccgagggcg cggacgacct gttggacgac ccacacgttc
    14161 agctcggcga ccgtgtgcac cccaggacag gtggacgccc ggtctccttg aacgccgctc
    14221 cacgttccca ggccgctggc ggtgaaggtg ctgaatgggc tggtcttcat gctgacccgc
    14281 gcaaggtact tggcgagccg cagcgccaac gagcgttccg gcgcccgctc gtcagggagc
    14341 gcgagccact tgcgtacctc ggcgaggagc accggactgc tcaggacgag gccgtgctgg
    14401 aggacggggt cggaggctgc tttgcgcaac agcacgagtt ggctgcatat gtggtgagtg
    14461 atcaggtcgt ccagccgggt caccgcctcc tgatggctgg cccgcagctg tgcccaggcg
    14521 tccaccagtt cgacgagcgc ccgggggagc agcgtccgaa gggcgtcgtt ccagtgacgc
    14581 tcggtgagtg gacggcgatt gtgaatggcc cgacgcacgg ccaccagcag cggcttggcg
    14641 gaaccacctc gcccgatctg ctcgtagaga ctgtcggaca acaaggatgc ctggccgtcg
    14701 agttggtttt ccaggtcccg cacggactcg gcctggcgcc acaactccgg cgagcgcata
    14761 tcgtccagca tgggcgcggg cagcccgccg atccgtacgc cgaaggtgtc cggggtggtg
    14821 aagtcctcgg tcatggccga ctccagtcac gggaggtgcg aaaacacggg ggtcgtgggt
    14881 ggcgcgcgga cgtcacggga acgggtgcgg gtgcgggttg atgtccttct cggccaacgg
    14941 atcgccgcgg tatccgagtt cggaggggag ccgcagcagc cggggaagcc cgtgggtgcg
    15001 gcgcatccgg tgcccgaacg tcatcggcag cagccccggc acgatcacct tcgcgcaggc
    15061 cagcccgccc gcccggtgct cgttcgtggt ctggtcgacc acgacgacgt ccaggccccg
    15121 gtcggtgaac cgagccaccg cctcggccag atcctcgcgg atatccgtgc cgcgcggtcg
    15181 gcaggtggcg tgcgcgaacg cctcctcgac gggccggccg cccgtctcgg cgtcaccgcc
    15241 gtcgccgagc aggaaggcga accggtcgaa cgcggccggg tggcagtaca gcagtgcatg
    15301 gtcccgcatc tcgcgcacca gatccggctc gtcgaccatc gccgcgatgc gttctcgttc
    15361 ctcgcggaag gcggcccggt tccaccccag gttcgccgcg agttccaaca gtccgttccg
    15421 cagggcgcct tcggggtcga agtgggctcc tgcggcgcag accgcggcgg gctcgtcggc
    15481 ccggcccggt ccgctcggac ttatggccat cacccatgcc gtggggatgc cgtgctccgg
    15541 ggtggtggcg aaggccagca cccggtggcc gctgtcctgc cggatacgct cggcgagcgc
    15601 accgatgcgg gggtcggaca ccgtccgcag gtcgacctgc ggcacgggga ggcgggcgta
    15661 ccaggtcagc aggaacgcgt cccgctcggc gagttcgacc agcccgtgca gcgctgcttc
    15721 ctccagacag ccgcccagcg cgcacccgtt ggacacttcg tacgccaggg gccgtgctgc
    15781 cgggttgccg tgccgggtgc ggtagtacgc gtagtcctcc ggaaccagga cgggggcatt
    15841 acgggcgaag gagtgtcccc acacccagtt gagctccagg tccgggtcgt acggtggata
    15901 ggggaagtgc ggctcggcat agcgctcggg cgggtacagg cccaggtcga ccgggcacag
    15961 tgcccggtcg gcgatctccg cgtagccgga ccgcaccgtg gtccggcgcc cgccgggctg
    16021 ggccccgccc agccgctcca gggcctcggc gagcgcggtg cgggcgcagg ccccgtaatc
    16081 caggtcgcgg ccgaacccgg cttcctgctc cccgcccggc aggtgcagtg gggcagagac
    16141 catgggatac gggtagtcgg tccgcacgtc gagctgccgg accagtcccg tgcgtccgtc
    16201 gacgtatcgg gcaaccacat cctcccagtc cgccctcagg tcgcgcacgc gcgggacatc
    16261 cggggcgagc ttgggccgag gccgctccat gaggacgggt ggccggtcct cggggatccc
    16321 gccgcaccag gtgcacgccg ggtcgggcag gaagcggtgc acgtcaatga ccatggtcgt
    16381 caacgacagg aaggcgaggg cgctgtcggt caaccgactg gaggtggacc tcagttcgct
    16441 ctcgacgagc acggcggccg tctcgcacgc ccaggtggtg aggatcggtg acgcacgatc
    16501 ggcgagccgg tcaccgtgcc gctccatgag agccgcgcgc ggactgtcct tgccgagagt
    16561 ccgttgccgg cgcgtccggg cgcagcgggc gcagccggcc cgccccggga cggtcgtcgg
    16621 gccgaccacg agcaggccga gctcgacccg tactggtagc cagggtacgt cgggacgcgg
    16681 cggctcggtc gcggtcatcc agccgtcttc ggccgtgacg accgcggcac acgcggggtc
    16741 ctcctccggg accagccggt tcgtacgagc cagggcgaca cggatcgtcg aggcgaggac
    16801 gcccttgccg acgacggcga tgggggccgc gggggccgca ggggctgtcg tggggtctgc
    16861 ggggtgcgcc gggcggaggg tttcggcgag ccgtcctgtg cgggaggctg tcgctgcgtc
    16921 ggtcaatgtc acatcctcgt cgttcgccgg gacgccgcgt ccggcgggcg cggggcccgc
    16981 cgaacgcggc cgtgctgccg cttgtttcag cagcagcagc aggaacagca gctcgccggg
    17041 gtaccggtgg acgtgcagtt ggacgcgccg atctcgacca tggcgtggcc cacgttcacg
    17101 gtctccaggc tcgcgcccgg cgaggtcggc aggatctcca gctcgtccgc actgaggtcg
    17161 gcgaggtcga ggacgagttc gttctgcatc gcgatcccct ttctccttga atggatgaga
    17221 agttggccag tgactggtcg ctccgcatcc tgcggtcagc gagcgtgcgg tgtcttcacg
    17281 gtccgaccgc aggaccggcc gcagtacggg gctgcgggcg aggccgtgga ccggccgcag
    17341 gagggacgtg cgccgcccgc gaggcaccgc aggtgcggtt caccagatca gctccggctc
    17401 gtactgggcg gtgggccggc ggcggcccac gatcagcgtg aacaccggca cctgggcggc
    17461 gtccaggccg atcaggtccc ggaccatccc gtcgtggtag ccgttggtga tccgtgcgga
    17521 cagcccggcc gcggcggcga gcacgctgac ccgctgggcg acgatccctg cctcctggtg
    17581 caggacgcgg tacccacggg cgccgaacca ccggtccccg gcgagccggt cggcggtgag
    17641 gaatacgacg gcaccggcct tcgccgcgtt caccgccggc gtccggtcgc acagcatgcc
    17701 gaccacggcg cgccagtccc gcgccggcag tcgcaacagg gcgggcggct ccatgccggc
    17761 ggccaaccgg tacagcccgg gggaggcccc gtccgtgccc agcacgagaa cataggcccc
    17821 cacgagaggg cggcacggcg cctccgtatg gtcggacgag acgggctcca gcgcataccg
    17881 cagtgccgac gccagtcgtg cgaaggccac gggccgggcg tccgggagga acatccgccc
    17941 gcccgagtcc cgggcacgca gcgcggcggc caggtccatt ccaccggccc cgggttctgg
    18001 ccccgcgagc ccgaggacgc cgtccgggcc cgacgcctcg acaggcaggc gaaagtcgtc
    18061 gggggcgacg gcggcaccgg gccccgcgag ccgggcggtg aggtcgagcg cggtcagacc
    18121 ggaccacgtg ccgtcggacg tgcgatcggt ctgtacatga acgggctgaa tatgcggtaa
    18181 ctcgcatgga aggcagggct gttgagaaga tgcgacacgt gcctgcgccg gcgccgcctc
    18241 cccggccggg gccaggtcga gcacggcgaa cgccgtctcc tccctcccgt cgagccccag
    18301 ggcgcgattg accacctcat cgtggaagcg atagtgcacc cgcccgcgga gcccgagcgc
    18361 ggcaccggtg agcagcgcgt tccccaccgt cattcccgct tcctgcgcac acagccggta
    18421 cgcgtagtcc cggtagcgga acgcggtctt gcggaaccag gcggaagcca ccaggagtcc
    18481 cgcctccgcg cgcacacctg cgccgatgcg caccgcgtgc ggcacaccgc cctcgcgcag
    18541 cagcgtcacg gagtggtgcg ccgggttgta gtggtagcac ccggcgggca gctcacccgc
    18601 cggacgtgcc agccacacat acagctccac ggggtggaaa cagcgcgcgg aggcgaccat
    18661 ccggtgatag ggccacacgg catgcggacc gagctcgatc cggccgatcc cgtacgtcca
    18721 gtacagcagc gcggagagcg cgcgctggtc caggacgtcg agggtgggga tgccctgcgg
    18781 gtgggcgtcg cggaaggctt cgaaggacca gcgcgcgtcc cctatccgcc gcgccggctc
    18841 gggaagtacg tggcggggca gctcgcggta cgtcttgacc ggcagcgggt cgtccgggcc
    18901 gccttcttcg ccgtggccct cggcgaagag gtcctggacc ccctcgaagg tccgccacca
    18961 gaaccgcagg ccgacggaac cgtgttgccc gactgtggcg ctacgcatcg ccccgagcct
    19021 ccacccgccg caccgctccc gccggaccgt cctcgtcccc ggcctcgtcg gcgatgacga
    19081 cgcgcacgac gaagggcagc acctcgtgca ccgccggatc gtggtcgagc ggcactacga
    19141 gcgggcgcgc ccctcgcgac cgcaacgcct cgaccatccg ctcgggcccg gccggcaccg
    19201 gcaactcggc actgtcgtcg caggtgacag gcgcgccgag cagcccccgc cgggccggtg
    19261 cgtaggcgga ttcgcccgtc atcaccgact ggcggtcgag cagggcggcg cggagcccct
    19321 cgacgaccgc atcctccccg cacgtcgcgg cggccgggcg gccaccctgc caccaggcga
    19381 ggacaggcac gcccagcgct tccccgatat cggccacctc gaccgagccg cgcgaggcag
    19441 acaggaggtc gaggagacgc cgttccccgg ggtccatggc atcgggccgc agccgcacgg
    19501 gccgaggtcg cgaccgcccc tccgccacat cgcgcagagc caggcgcacg cactgctggg
    19561 cgaggccgtc cgccacgccc tcgtcccagc tgagccgggc ggccactccg acctcgtggt
    19621 ccgtggtgaa cacccggcac gccgccaccg cctccgcgcg ccgctcgtca agggcccaac
    19681 cccacacggt gccaccgggg ccgtagcggc gttcgtcggg gtggtgcgcc gcgtacgagg
    19741 cgagcccgcg cagcgcggcg tcccggcgtg ctgcggcaaa gcccgtcccc gccccgtgca
    19801 ccggcgcttc gccctccgcg cgcggcaccg cctcggtcac gttgagcggc acctgggtga
    19861 actctctctc gtcgagggcg cgtagaacac cgatgtacgg gtcgaagcaa cgggccgcgc
    19921 gccgggagaa cgtgtcctcg tccagtggtg ccgcggcacc gagtcgttcg atgcgccgcc
    19981 tgaactcctt tcgcgtctcc ggacgggccg gggccgccgc cgggtggagc agaaacgcat
    20041 gtgtcgaggt gcgcagggtc tccagatcga tccgcgtcac tttccgcgca ccatgcgcgg
    20101 cgtccatggc gccgacgatc ccggtgagtg tggtgaaggc cgcaagcccc aagtgcgcgg
    20161 cgaccaccgc ggcggcgggc ccggtgagga aggcattcgg ccggaacggt ctgcgggcgt
    20221 cgagccgcaa ccacgccgat cgccagtcgg ctccggccgg ccccagccac gcgacatcgt
    20281 ccaccaccag cccctgcacc agtagtgtgc ccgcattccg gcacagctcg tcgagtcgca
    20341 gagcccggtc gactccacta ccgtccgcga cgtgaatcac cgcgcccacc tggccgacaa
    20401 gtcgttccaa ccctcctttg tcacaggcaa catgacggaa cgtctgctct ggatcccgcg
    20461 cggcggcttc ggccgtgagc tccgccaggc gctcggcgtt ggtgacggcc ttctccgtac
    20521 acacggctcg cagctgccgc accccggagc gcagcgccga gcagaccagc gagacgaata
    20581 cggggcccgc gcccaccacc acgacctcgc tgtcgcggta ggtctcgaac cgccgcgccg
    20641 cggagtcgca gtggtactcg atgaatgcga tctcggacgc gtacgtctcc agctcccgcc
    20701 gcgtgagccg gtgcggcagt tcctcctccg catcgataag gcagccggcg gcgtgcaatt
    20761 gacccacgag ggagtgcacg acctgccgct tgtcgtcggg cagtcgcccg accaggtcgt
    20821 cgagctcgac cgaaccgtcg agatgtggcg ccagccggtc cagccactga taggcggacc
    20881 ggccgcgcag ggcgaggtcg gcaccggcac cgaagacgtg gacgccgtca cccgtcggca
    20941 cgtacagcac atcggatttg agtcgcgggc gcatcatccg ccttcggggt cgggcatccg
    21001 ccaccccggg gccgacgtgt catcggcccc ggagacggaa ccggtcggtc ggggcccagc
    21061 cgagtatcgg ggcgccttgt gcccctgtct tcacggtcgg gccacaggat ctaccgcagg
    21121 tttctgccgc cgccgtgatt gcggctttcg gatgggaaat tgcgccgctt ggcgtgagct
    21181 gccgcccgaa aggagaccag gccgctcgct caacggtagg gctccgctgc accagcctgc
    21241 tgcgcgcgag cccggaccgg cgcccggaat ccggcccgcg aggtcgccgg ctttctgccc
    21301 agccgtggcc agcttgtact cactatcgac ctggctcacg tgaacgcaga acccgggggc
    21361 gccacgcggt gctcgcgacg atcgccggag aggacagtcc cagcgcggcg ttgtcccggc
    21421 aggtcattac caggagaatc gcgacccata ggcaccccca cgcccgtctg cgtactcgat
    21481 gggagacccg cgacgacatt cacgaagcgt tcctcgcatt cgcatgctca ctcatctgct
    21541 ggcgccgcct gcaaacagca ttgcgtgagg agctcttgag ggcgccattc ccggcggtag
    21601 gtaggggcgt tcggcccggc cctgcgcgag catgcgaagt gtgctctggc aatgcgggat
    21661 cggcatcgac ctgccgcccg cgccggacct ggacagccac gactttgacc agctcctggt
    21721 gcacgccgag ggcgtgtgga aaccgggcgg cccagggcca ccccgtccgc accgccaccc
    21781 ctgagactct cgtggtgccg tactgccgac gcgtcgtggg aagtctgcgc ctactgccag
    21841 ccctacacct cacaaagtga gcggcatgca gcgttccccg actggctgga ccgcacaact
    21901 accaccgacc ccacaccgga atcagcggcc acaccccagc cagccgcgtc accgacctca
    21961 ccgaccagca ccccagttct gtccgtactg ccagctgatc gcgactgtca gccgatcgcg
    22021 agggcggtcg atgcgtcgat gagggcgagt tggcccgggc tggctcttcg ggtccgggcc
    22081 tgttcgacga aagggcccag ctcggcgcgg agggtggccg agtcgatgcg cttgatcacg
    22141 ggcagcgtgg cctcgacgat ctgacaggcg tcgtcgaggc ggccgacacc ggccagggct
    22201 gtcgcctgcc gaaccgcgaa gcgggcctgg gagttgtcgt ccgccgggac ggccggccgg
    22261 cgccggcgct cggcggcgaa aaggtcggcg gccagctcga agcgacggag gctgagcatg
    22321 caggacgcct cgatgagtcg agggttgccg ttctcgatgc gcgggcccca gtgaggggtc
    22381 cggtcgccag tgacttcggc ggcgtagcct ctgaaccgct ccagtgcctc ccggcacgcc
    22441 cccgcatcgc cacggcacgc atgcccctgg gccgcgcgtc gcgcggcgtg cgcgcggatc
    22501 accgggttgg ctgccgggtg cccggccgcc tggtcagcga atccgatcgc cgcatgggtg
    22561 tcaccgcggt gctgggcgat gaacgccttg cggaccaggg catacgcggc caccgtttcg
    22621 tccccgccga gtgcgcccca gcggacggcg agattcgtcc agcgcaacgc ctccgcggga
    22681 tttcccgcct cttgtgccat ccaccccgtg tattcggcga accttgaggc gagccgccag
    22741 atctcggcac gctgctcgcc aacggcatgc gggccggcgt ccgtcaggat ccgcgtgatc
    22801 gacttcatcg aggcggtgac gaacctgggt ccggtggatc tgccgatgcc cttcagctcc
    22861 cacaggaccc gctcgtatcc ggcgaccacg gggccggcct cgacgatgcc ctcggtccgg
    22921 gcgccgcgcc ggccggcccc ggccagctcg acgagttccc cgccggtgcc gaaggccgcg
    22981 tcgcatgccg ccgccacagc gggcgtcggg ttgcgcaacc cgctctccag attgcagatc
    23041 tgcccttcgg acacgttcgc acgccgggcg aactcgcgca cgctccaccc ccgacgcgcc
    23101 cggagtgtgg ccaggacgac gccgaagtcg cccggcggca ggcgcgtgcc ggtcgatctc
    23161 cctgccgaga ccgtccctgt cgcgctgtcc gccgggtcca taccggccag cgtacggagc
    23221 ctcgcggccc ctattcaatc cccggcgaat agccaccgag cgtgtactcc actcctaggg
    23281 tgagcaccat ccctgacgtc aaggcttgcc ggataggggg caatggtgcc gcgcatcttc
    23341 ctcagctttc gcaaaccgga ctcccggtgg atgcgagacc gcgtctaccg cgcgctgtcc
    23401 gaccgcttag gtgcccacga gatcttcaag tcgggccagt cgattccgcc cggggccgac
    23461 ttcgccgaga tcctgcggcg gcaggccgcc gagtgcgagc tcatgtgtgt actgatcggg
    23521 ccacggtggc tcgacgcgcg ggacgaggac ggtgtgcggc tcctggaccg ggctcacgac
    23581 tgggtccgcc tggagatcgc gacagctctg cgggccggaa accgcgtcgt cccggtcctt
    23641 ctgggtgacg cgacgatgct gcccggcgcc tcggcgctgc cggccgacat cgcggagctg
    23701 gcgcgcctgc agttcctccg cgttccggag acccatctgc cggacgggct ggagcacttg
    23761 ggcgatgcgg tgaccgctct cctgtccgat accgataccg ataccgaccc cgctgtcgag
    23821 cccgggcaca gcacggcacc ggccgctgat ccggagccat caatgaccat gacggctcat
    23881 gtgtccggtg gtggcagcgc ataccaggcg gcccgtgatc agacgatcag gctggcgtga
    23941 ggggcggacg atggatcatc cgggggcaga cggtgctcat cggatcgggc cgtatgccct
    24001 gctcggaagg cagagcacgg tcggcggggg cgaagtcttc gcagcccgca cggacgaagg
    24061 gcgactcgtc acggtcacgg tcgtggcgcc cgaactcgcc gcggacccag ggttccggga
    24121 ccggttccga gccgccgtcg aggccgcacg gacgctgtcc ggtgccttcc tcgtaccggt
    24181 ggtggatgcc gacgccgacg cgccggttcc ttggctggcg accgagttca ccgccggagt
    24241 gccgctccgg caggcggtgg accggcacgg cccgctgtcc gaaccggctc tgcgggtgct
    24301 cgccgacggc ctcgcccagg cgctggccac actccacgcg gccgggacgg tccacggcga
    24361 ggtgagcccg gactcggtcc tgctgaccat ggacgggccc cgcatcaccg ccctggggat
    24421 cgtgggagcc accggcagtc cggcaccctc accgacggac gacatgttcg acctcgggtc
    24481 gaccgtgctg ttcgcagctt ccggaggcga gccggacacg ggcgccctcg ccgtgtcgct
    24541 gcgcgaggtg atcggcggct gcctgtaccc ggaaccgcag gatcgtccca ccgcggagca
    24601 actcgtcgac tacctgaggc gtcaggacct gccggccctg agcggcagtt ggctgccgcc
    24661 ggcggtgacc gccgacatgg ctgccgcggc cgcggcggtc ggatcggtgt ccgccgggga
    24721 cggcggccag ggcccgtttc ctccgccgcc agtgatccct cccggcacag gtatcagccg
    24781 ccggaagctg atcgtcggtc tggccggggg cgcggccgta ctcggcggag ccgcggcggc
    24841 actcgccttt tccggcgact cctcgccggc acccgacggc cgagccggcg gacccgggtc
    24901 cactgcgcgg ccgacctctc cgtcaggcgt gcgatccact ccggcatcct ctgcgtcgcc
    24961 gtcctcgacg gacggaccgg aatcgatcgt gctggccgga cccgacgccg ccaaggcatg
    25021 gtcaggcgcc ggaaagcatg cccccaactg cctggaagcg tccgacaagg tggtcatggt
    25081 ggtcacgaac accggcacgt ccttcctgga cgccgcgacc ggaaaatcca tgttccccga
    25141 gctgaacacg accagcttcc tcggcacgac cagcctgacg tacccgacgg cgtacgcgga
    25201 cggagtgttc tacctgctct gcgacacccc gagtcagtca ggcatgctgg cggcgttcga
    25261 cgccgccagc gggaaggtga agtgggcgac caagatggcc gacgtcgatc cgggcggcgg
    25321 cacgcatgcg gcgaggtacc tgagcaacta tgtggcagtc gcggggaaca cggtgtacgt
    25381 atgcggccag atgagtcgga catccgggtc gttctcgccc gagtctccga ccaccggcta
    25441 catccgtgcg ttcaacgctg cgaccggcaa gggactgtgg cgggtcaagg gcacggacat
    25501 caacaacgtg ctcgtgccgc cctccggatc tcacctgctg gccacctcgg ccgttccggg
    25561 caagaaaccc ggccgcgtcc agatgatcga cgccggcaag aagggcgccc gcggctggaa
    25621 ggtatccgtc ccgcacgccg ggtactactt caccaccggc tggccgctga cgtgctacgc
    25681 cgccggactg ttcctgttcg ccggcggcaa cggcgacacg ctgttcgccg tcgacgcgac
    25741 cacgggcagc gagaagtggc atcggcgctt cgatgcgaag agcggggacc aggtccagat
    25801 cggcgccccg ttcgccggct tggacggcgc gaccgtctac gtaccggtcg gcagtgacct
    25861 ggccgccctg gcctcggccg acggcacgct ccagtgggtc gcgacgctcg gcggggccag
    25921 cgacatgggc ggttccaaca tgttcaaggc cgccctcagg acttccggca agagcgcgca
    25981 gtgttcggcc gacaccgtct tcgccaccga cagcgccaag acgctgtggg ccatcgacgc
    26041 ggccaccggc agggcccggt ggaaatacag cgaccccggg cagccggacg tggggttcct
    26101 gtggacggtg ggcggcgacc acgtgttcat cgcctcccac ctgacagtga ccgcgatcgc
    26161 ggcccacggg cggtaaggga caaggagaag acatggagac gagtgtggaa ctcgccggcc
    26221 tggcatcggc ggccgcggcg cgcctgatcg atctgttgac gacggacggc tgggccgcgg
    26281 tcaagtcctc ggtcctgtcg ctgtggcggt ccgcgcaccc ggagcgcatc gaggaggaac
    26341 tcgccgatgc gcgcggcgag ttgctgcaag cacagcagac aggcgacggc caggagctcc
    26401 aggggctgct ggtcgccgag tggcaggccc gcatcatccg gctgatggcc acgcggccgg
    26461 acgccgtcgc tgagctgcgc acgctgttcg gcgcggaact gcgccctgcc ggagccccgg
    26521 aacagcagat ctcgggctcg atgacgctgg aggcacacgt ctccggcggc gacgcgttcc
    26581 tggccggccg ggacatgaat gtcaccaggg gcggacaggc gtgacggaac gcagcaccgg
    26641 tgccccgtcc cccgacgggc cgcccctgtg gcagccgaaa cggcaggagg cgagcgcgac
    26701 cggcggcggc agcgtcttcc aggccggccg cgacctccac gtccgcgtcg gcgacgaggg
    26761 gcgcagaacc gtgcccggcc cgggggccga ccaagtgccg tgcccgtacc cgggcttggc
    26821 cccgttcggc gcgcggcaca agcagtggtt ctacggccgc gagcgaatgg ttcacctcgt
    26881 gtgcgagcgg atggacgccc ggatgcgtga gggcggcccg ctggtgctga tcggtccctc
    26941 gggagccggg aagtcctcgc tgctcgcggc cggggtgctg ccggccctgg acgacggccg
    27001 gcttccggcg gcgggttcga gcacctggcc gcggctgctg ctgaccccga cggcatcccc
    27061 ggccctggcg ctggcggccg ccgccaggct cgacgccgag accgcccggc gcaccgcacc
    27121 ggcgtggcgg gccgatcccg cacggtgcct tgccgagctg cgcgagatca ccggagccgg
    27181 cgatccggca cccaccgggg agtccccctc cgcgggcctg gtcgtcgtgg tcgaccagtt
    27241 cgaggagatc ttcacggcct gcggcgacga gaccgaacgg cagtggttca tcgacgtgct
    27301 cgaccgtctg gcccggcccg cgggcggtgc ggtcgtggtg ctgggggtgc gcgcggactt
    27361 ctatgccgcg tgcacggccc atccgcagct ccgggcggcg ctccaggccg gtccggtcct
    27421 gctggagccg atgacggagg acgaactcaa ggacgcgatc cgccgcccgg ccggcaacgt
    27481 gggactcgac gtcgaagacg gcctggtcga ggtgctgctg gcggacctgg gcgcggtcgg
    27541 ggggccggtc ggtacgagca ccacgggccg actgccgctg ctcgcacacg cgctgcgggc
    27601 cacctggcag cagcgccacg gccacacgct caccgtggac gggtaccgcg tcaccggcgg
    27661 catccagggt gccatcgcca atacggcgga caggctctac gacaccctgc cgccgccctg
    27721 ccacgaggcc gcacggtggg tgttcctgcg gctcgtcatc gtaggacgcg acgccgacga
    27781 cagccgccgg cgcgtccggt acgacgagct gctgcgtcac gcgccggacc gggaagcggc
    27841 cgtcagggtc ctggacgact tcacccgcgg ccggctgctg acccgggacc aggacacgat
    27901 ggtgatgaca catgaggtgc tcatccgcgc ctggccccgg ctgcggggct ggatcgagca
    27961 cgaccgcagc ggaaacctcg tacgacagga cctggaagag gcggccgagc tctgggaaca
    28021 ggccgaccgg gaggcagccg cgctgtaccg cggcaaccgc ctggaggccg ccctcgcctg
    28081 ggccgaaacg cacgggccgg aactcagcgg cgccgcccgg gcatttctgg cagccgcccg
    28141 ccaccaccag cggcgcgggc aacggctccg gcgcgccgcg gtcgccacca tcaccgccct
    28201 ggccgtgatc gcctcgctgg ccgcggtgtt cgccttccgg caggagtcca acgcccggaa
    28261 ggccgccacc caggcccttc gagcccgcga ccaggccatc aacgccgccg tcacctccgc
    28321 gtccgtgcaa ctggcgccga ccgatccctc gctgtccgct caactcgcgc tgaccgccta
    28381 ccgcatggac ccgaccccaa aggcggcgtc ccggctcatc acgaccgaga acacaccgct
    28441 ggacacccgg cttcccggcc cgcgcggcgc ggtgtacacc gtggcctaca gtcccgacgg
    28501 gcacatgctg gcggccggga acgtccacca gaggctcgtc cggctgtggg acgtctccga
    28561 tccgagccgt ccggtggcgc tgggccgacc cgtgccggtg gaccgttccg tcgattcgat
    28621 cctgtcgctc gcgttcagcc cggacggccg ggtgctggcc gtcggcggac acaccagcca
    28681 caacggcgat gccggttccg gcggattcgt cgacctgtgg agcctgacca gccccagcca
    28741 cccggtcctg ctgggccggc cgaagagccc cggcattcag ggcttggacg ccgcgacctc
    28801 catcgaatcg ctggcgttca gtcccgacgg ccgtaccctg gccgccggat ggcacgccgg
    28861 attcgtcagc ctgtggaacg tcagccgtcc cgacgacgtc aaacccgcgg gagcgcccct
    28921 gaacctcgac tgccccggcg tcttctccgg tcgcatcgcg ttcagcccca ccgggcacac
    28981 cctggccgcc gcatgcgacg acgatgccgg caccatccgc ctgtggaaca ccaccgaccc
    29041 agcccacccc ggccgcggcc gttccctgaa ggccgggcat cgcgtcatct ccctggcgtt
    29101 cagccccgac agccgcaccc tggccgccgg aatcgaggac agcacggtcc acctgtggaa
    29161 ggtcgcggac cccagccacc ccacccccct gggcaagccg ctgaccggtc ccgcccagcc
    29221 cgtcatgtcg gtggtgttca gcccggacgg tcacaccctg gccgccggca gcgccgacca
    29281 caccatccat ctgtggaacg tcacccactc cagggctatc ggccctctgg gccggccgct
    29341 gaccggtccc ggcgacgcgg tgaccgacgt ggtgttcagc ccggacagcc gcaccctcgc
    29401 cgccgggaac accgacggca acgtcgatct gtggaatctg ccgccgaccc ggatcatcgg
    29461 cgccggcggc aatgtggcat ccgtggcgtt cagccccgac ggacgcaccc tggccgccgg
    29521 aaaccagaac aacaccgtct cgctgtggaa caccgccgac cccaaccacc ccgctccccg
    29581 cggtgatccg ctcaccggcc ccaaggaacc ggtcgacgcc gtggcgttca gcccgaacgg
    29641 gcgcaccctg gccgcaggcg acagcggcgg caccgtcacg ttgtggaaca ccgccgaccc
    29701 cagccatccc gttcgcctcc gtaagaccct cagcggggcg gacgggacca tcttctccct
    29761 ggcgttcagc cccgacggcc acaccctggc cgcggccggc gacaaccacg atcgtggcag
    29821 catcgccctg tgggacgtca gcgaccccgc tcaccccgac gcccagcccg gcatctccaa
    29881 tgaccacacg aggtccgtcg aatctctggc gttcagccgc gacggcacga tgctggcggc
    29941 cggcggcgac ggcagcaacc atgaggtcgg cctgtggagt acgacggacc ccggggtccg
    30001 catcggggag ccgatcgacc agccgaacgc caccagcacc tgggtcgcgt tcagcccgga
    30061 cggccgcacg ctcgccaccg ggaacagccg cggcaccgtc accctgtgga atgccaccga
    30121 cccccaccac ctcacgcgca ggggcagtcc cctgaccgta cccggcggca gcctgtggtc
    30181 ggtggcgttc agcccggacg ggcacaccct cgcagcggcc ggccacaccg acgacggcac
    30241 catcaccctg tggaacgtca ccgatccgga ccgccccacc ctcatcggcc gcccgctgac
    30301 cgtggagacc ggattcgccg ccgttctggc gttcagcccg gacggtcaca ccctggccgc
    30361 caccaccgac gacggcgtcg ccacgctctg ggacctgaac gtcaagtccg ccatcagccg
    30421 tatctgcgcc gggagctccg gcgccttgag ccgccagcaa tggagccgat acgttcccca
    30481 actgccgtac gacccaccct gcgtgaccac ctaggcagtt tcgttgggac cagtcggtcg
    30541 ttggttcgag tctggcatca actgatgtgc agggggcgcg aatcgagcgg ttgctcccgg
    30601 accggacgcc gaagaggggc ggccgctggc gggatcaccg ggaggtgatc gacgagatcg
    30661 ctttactggt cggcttcgga aatccttcgg gggtcgacgc ctcttctccg gctgtcagac
    30721 gtggctgcca cactctcctc ccatgacggc accaccatgc tggaccgatg acctgttccc
    30781 gttccccacc ccacccgcac tcgccaaggt gatcgacatc gcctgggagg aggggttcct
    30841 cacgacggac ctatacgagg agggcctgta cgacgctggc cgcgtgcaga ccagctttgc
    30901 cctgccgttc gacctgtgcg aggtacccct cgcaccccag g
//
