LOCUS       NZ_AP026073            22538 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 chromosome.
ACCESSION   NZ_AP026073
VERSION     NZ_AP026073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8253039)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3552327
            Orig. end                         :: 3574865
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026073.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22538
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="11"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22538
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22538
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12538](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12538
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(415..430)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            544..1173
                     /locus_tag="HEK616_RS15605"
                     /old_locus_tag="HEK616_31690"
     CDS             544..1173
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601762.1"
                     /locus_tag="HEK616_RS15605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31690"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_261953556.1"
                     /transl_table=11
                     /translation="MFEGVDLEVPAGGLLAVHGPAGSGRTSLLLALAGRMRLSGGAIRV
                     GGSVLPAEGRRVRAAVAVARAAPAVALEGRLRVTEVMAERRLTGAGVTERRIREAFEIV
                     GIAPRRSDLVEDLDPVEALLLAAALALAERPGALVVDDVDEGLPPDAHDSVWQALDRVR
                     NSGPTVLAGCLRTPSPTAGLVALSLPRRSRDRLPADTTVAREDADI"
     misc_feature    655..657
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1170..3113
                     /locus_tag="HEK616_RS15610"
                     /old_locus_tag="HEK616_31700"
     CDS             1170..3113
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601761.1"
                     /locus_tag="HEK616_RS15610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31700"
                     /product="YhgE/Pip family protein"
                     /protein_id="WP_261953557.1"
                     /transl_table=11
                     /translation="MKAVKLALLELRRFRGPVRRLVPVLLCLVPLLYGAMYLWANWDPY
                     GKTDRMPVAVVNQDHLAHAKQGRRVDAGDQLVQQLKASGTFDWHFVGRDEARDGLEHGR
                     YFFTIHIPPDFSHKIATGADTRPQQAGIRIELNDANNYIAGIMTEVVQTKLQDQINSAT
                     HAAYVRSIYGELSAVRAKLTTASDGAHRLVGATRVAQQGTSTITSATSTLHDGAFDVAS
                     GARQIARATGQIDDLTGRLDQAAADRLPGAASALVSTARLTADGLDAVHTATTATRKGT
                     SRAVADLTALATTHPELRDDPVYRRALGHARSLDSTATALDGRAAAAENNARRSLDEAE
                     RLQDDVGSLQRDVLALHTPLRLVDSGSHSAADGAHGLVAGLATLEKGSGALHTAAEQAH
                     GGASEVSRTVDDGLHKIPRTSPDQVAHAAEVLGTPVHIDRTNLHPAGVYGRGLAPFFFG
                     IALWVFGLFAYLLLRPLNTRALAGRVSAFTTAVAGWLPAALLGAVGALVLYGVVDLTLG
                     LNPVHGFWTLALLVTAAAAFVAVDHCLRTVFGVPGDVLSLVLLILQLTASGGLYPLPTE
                     PAFFQVLNPLLPMTYLVDGLRVTVSGGLTGNLLRDFAVLLACTAGFLAVTALAVRRQRV
                     WTVGRLHPDVSL"
     gene            complement(3221..4105)
                     /locus_tag="HEK616_RS15615"
                     /old_locus_tag="HEK616_31710"
     CDS             complement(3221..4105)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180892.1"
                     /locus_tag="HEK616_RS15615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31710"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_261953558.1"
                     /transl_table=11
                     /translation="MSENFLLADRFEVERPGLRAVAYRMLGSLAEAEDAVQEAWFKLSR
                     TDVSEVKNLGAWLTTVVGRICLDMLRSRTSRREDPLPEQDGSVRLPDPVVTALARVDPE
                     QEILIADSVGIALMIVLETLAPAERLAFVLHDMFDVPFDDIAPILGRTTVSTRQLASRA
                     RRRVQGAAPAADTDLTRKRDVVNAFLAASRGGDFEALLAVLDPDVVARSDGGTLVPSVL
                     RRGAADVASQAITFARFAAEARLVLVNGTPGVVSFAEGRPLSVMSFTIRDGRIAGLDIL
                     TDPDRLTTLGLSA"
     gene            4528..6930
                     /locus_tag="HEK616_RS15620"
                     /old_locus_tag="HEK616_31720"
     CDS             4528..6930
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960405.1"
                     /locus_tag="HEK616_RS15620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31720"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_261953559.1"
                     /transl_table=11
                     /translation="MGRERELARLRTLLRSSRLLTLTGPGGVGKTRLAVELAGGVRGGR
                     AGRAQLVELAGLHDGELLPQTVAAALGVRERAGRTGTEALVRALEKRSTLLLLDNCEHL
                     AEPCAVLAAALLTRCPGLRILATSREPLRVPGEVVFRVGILSLPPGPAGAGGDQHGDQG
                     TDPLLRSEAVRLFLERARTCHSGFEPTPGDVRTVAEICRRLDGLPLAIELAAGRMAALP
                     PAGILRGLDDQLSLLTDGSRTGPGRHRELGATIDWSHRLLDPLERAVFRRLSVLGGGFD
                     AESAAAVCADCATAADGVEGCVGCRDGRCCVRRKQVLPVLCALEAKSLIVRVHGDAPGT
                     ARFRQLAAIRAYGMDRLAEAGELPAVWDRAVDRLAEQAAEGSTMVFPDGAALPLAREQE
                     NLAAAVARCGERSDPRHTELALALARLHYQQEQLTAARTLLTEVLARTTYGSRDHGAAL
                     ALAARAACQQDDRSAALAFAREAVAVERAGPPHPGRLANALDALAAAHLCRGAYHEAVA
                     VFAECVAVVRTLDRPLDIAVCGHHLAWALLQTGDTAQAAALMEKCLPVLESGAPPGQAA
                     AALHTSGAIQLALGNWDAAENRFAEVLAKVPDGESLHALYPVEGLAIVAAERGAPERAL
                     RLYAAAAAARQRTDAEPEASWRTTVEAAASRARERLHPARVDAAMTAGRRLYGERLLSY
                     ALRDNASADRSTHANHDDPTDVAHPTPTEPISYPVTQLLLTPRELTVSQLVAEGMTNQQ
                     IAAQLGLSKSTVASHLDRVRDKLGVRSRTQIAVRVSGRAGGPGAESV"
     misc_feature    4531..4542
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
     misc_feature    6430..6432
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7434..8162
                     /locus_tag="HEK616_RS15625"
                     /old_locus_tag="HEK616_31730"
     CDS             7434..8162
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607439.1"
                     /locus_tag="HEK616_RS15625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31730"
                     /product="dioxygenase"
                     /protein_id="WP_261953560.1"
                     /transl_table=11
                     /translation="MRYADETGPDDAAGTQHGSRRSFIRSTSAGVTAVALGASVAASAG
                     PSAQAAEAAAPGARRGTRPLAVTPACSGQETPASIEGPLFKPNSPARSDLITPAIQGVR
                     LDLSGVVYDTSCKPLPETLIEFWQCDQNGDYDTSGFSLRGHQYTDSRGAYQLRTIIPRD
                     YWGRWGQRAPHIHTRVQASGGPVLITQLYFPDSTQAYGRDFAALNAADRLLNRACTISL
                     TGQEGGRYTGAFDFVITTTV"
     gene            8313..9482
                     /locus_tag="HEK616_RS15630"
                     /old_locus_tag="HEK616_31740"
     CDS             8313..9482
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607440.1"
                     /locus_tag="HEK616_RS15630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31740"
                     /product="hypothetical protein"
                     /protein_id="WP_261953561.1"
                     /transl_table=11
                     /translation="MPSHSPFPRRRSVRVSLLAALVATVVTGSLVLVGQSGDPTTPTAA
                     SAPAASLAPAAPHAGAWQATPVPVKKGDLTAVAALSDKQAWAVGYRLKSATSLEAVALR
                     WDGKTWTQESTLPDNSFPQALAVRSATDIWAVGSASAHWDGTKWTAYQLDKDPSGHVVP
                     DAVATTSDGKVWTAGRAMGRSIKDGVPAVQSWDGKAWHRQSLPDVGKGELSGITAVAPD
                     DIWAVGAAYAPDEKSQQSALLLHFDGSNWRRVAAPGPQTTHNWLGGITALSADDIWAVG
                     GSTTGSTERPLAVHWNGSTWTTARTPDVADGRLRGVGKTGNGDLWALGGKGAAPVALHW
                     NDQHDQWEKTTAPDLVIRSFTTVPHSADLWATGISPHGDLIPAITRLKN"
     misc_feature    complement(9694..9710)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.62"
                     /tool="antismash"
     misc_feature    complement(9696..9709)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.63"
                     /tool="antismash"
     misc_feature    complement(9697..9706)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            9786..9920
                     /locus_tag="HEK616_RS15635"
                     /old_locus_tag="HEK616_31750"
     CDS             9786..9920
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="HEK616_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31750"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_018090024.1"
                     /transl_table=11
                     /translation="MEEQNELSTVEPYAAPMLVEVGEFNEDTLGFIGWGKDIFGHYGG"
     gene            10001..11878
                     /locus_tag="HEK616_RS15640"
                     /old_locus_tag="HEK616_31760"
     CDS             10001..11878
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078865739.1"
                     /locus_tag="HEK616_RS15640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31760"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_261953562.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.4e-36, bitscore:
                     125.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAGFVVLPDAASAVEVRAAVPWPAPQVLSHASGRPWLVGRWLP
                     DAVQVATAGPVRVAVIGICPVTATRLSELTARIRTSADIDALAAALPGSCHVIASLDGQ
                     VRVQGSITGLHRIFHTHLNGLPVAADRADVLATMTGAGIDERALALRLACGGLVPPPLS
                     DTPLWSGISPLPADHYLLLQDQQARQVRWWRPPTPDLSLAAGATALREVLETAMAGRAP
                     SAGRLSSDLSGGMDSTSLCFLAARTTPDLLTFRWGEAEAGNDDAAFAAHSIDALDRAEH
                     LVIPPTDLPALFTDPATTTELEEPYPFVRTGARTRHTARLLADRGVHRHLAGHGGDELF
                     TPFPGYLHPLLRRRPVTALRHVRGYAALKRWPLLHTLAALTRPGHQASWWRAQADHLTD
                     PPSRKRRPSLGWGLWPLRAPAWVTTEAIETARAGLGRTAAQAEPLSTDLGQHQTLLAVR
                     IAAPWYRLLARPFADAGVQLDSPFFDDRVVEAVLRVRTHEHAGPWHYKPLLAHAMRGIV
                     PDTVLGRSTKGEFSEEASTGLRRNLPALLELFDDSALAAHGLIDPAVLRTQLLAPQATN
                     AMNIALEPLIGCETWLRAATRPTAPTPARSTPIRPTPARRTTDTHAPAP"
     gene            11862..12113
                     /locus_tag="HEK616_RS15645"
                     /old_locus_tag="HEK616_31770"
     CDS             11862..12113
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175266.1"
                     /locus_tag="HEK616_RS15645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31770"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_261953563.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.3e-27,
                     bitscore: 93.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 2.6e-06,
                     bitscore: 26.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.5e-14, bitscore: 51.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLHPDVVSTDTDDGTVLLNQRTGRYWQLNTTGAHVLRELLAGHT
                     PNDIAADLAARHHIDSTRAEQDVTAVLTQLRTADLVTT"
     aSDomain        11865..12032
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HEK616_RS15645_Lasso_Fused_RRE.1"
                     /evalue="9.90E-09"
                     /identifier="RREFam003.1"
                     /label="HEK616_RS15645"
                     /locus_tag="HEK616_RS15645"
                     /protein_end="57"
                     /protein_start="1"
                     /score="26.2"
                     /tool="antismash"
                     /translation="HLHPDVVSTDTDDGTVLLNQRTGRYWQLNTTGAHVLRELLAGHTP
                     NDIAADLAARH"
     aSDomain        11865..12107
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HEK616_RS15645_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="8.70E-30"
                     /identifier="RREFam002.1"
                     /label="HEK616_RS15645"
                     /locus_tag="HEK616_RS15645"
                     /protein_end="82"
                     /protein_start="1"
                     /score="93.6"
                     /tool="antismash"
                     /translation="HLHPDVVSTDTDDGTVLLNQRTGRYWQLNTTGAHVLRELLAGHTP
                     NDIAADLAARHHIDSTRAEQDVTAVLTQLRTADLVT"
     gene            12110..12538
                     /locus_tag="HEK616_RS15650"
                     /old_locus_tag="HEK616_31780"
     CDS             12110..12538
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987089.1"
                     /locus_tag="HEK616_RS15650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31780"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_261953564.1"
                     /sec_met_domain="PF13471 (E-value: 3.1e-28, bitscore: 96.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLPVALSERPRLPLHRRPVPLLAVAAARLLAKLKPARLRRILEF
                     ARRGARPATAEQALAAREAVVAVSLRCAGQGCLQRSIATALLCRLRGAWPTWCTGVRTH
                     PFAAHAWVEADGHPVGEPHPKGHFKPLIAVPPLSPAGE"
     gene            complement(12553..13737)
                     /locus_tag="HEK616_RS15655"
                     /old_locus_tag="HEK616_31790"
     CDS             complement(12553..13737)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948507.1"
                     /locus_tag="HEK616_RS15655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31790"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_261957274.1"
                     /transl_table=11
                     /translation="MDEALIRSLTPSVLTVLVRRGADFAAAEDAVQDALVEAVRVWPAD
                     PPRDAKGWLVTVAWRKFLDATRADAARRRREERVEEEPASGPVPAADDTLQLYFLCAHP
                     SLTPASAVALTLRAVGGLTTRQIAQAYLVPEATMAQRISRGKRTVSDVGLSPARAHSRA
                     GGRFDRPGDVATVLRVLYLVFNEGYSGDVDLAAEAIRLTRQLAAAIDHPEVAGLLALML
                     LHHARRAARTAPDGSLVPLAEQDRGRWDTKLIAEGVEILQAALARDRLGEFQAQAAIAA
                     LHADAPTAEETDWVQIVEWYDELTRLTDSPVVRLNRAVAVGEADGPRAGLAALAELDDA
                     LPRHTAVAAYLHECDGDLATAARLYAEAAHKAPNLAERDHLTRQAARVNARLSR"
     gene            complement(13755..14162)
                     /locus_tag="HEK616_RS15660"
                     /old_locus_tag="HEK616_31800"
     CDS             complement(13755..14162)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007512669.1"
                     /locus_tag="HEK616_RS15660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31800"
                     /product="YciI family protein"
                     /protein_id="WP_261953565.1"
                     /transl_table=11
                     /translation="MAKYLLLKHYRGAPAAVNDVPMDQWTPQEISAHVQYMNDFAARLE
                     KTGEFVDGQALAPEGKWVRYDGEGRPPVTDGPFAETKDLIAGWMVIDVDSYERAVELAG
                     ELSAAPGAGGKPIHEWLELRPFLTAPPTITE"
     gene            14284..14814
                     /locus_tag="HEK616_RS15665"
                     /old_locus_tag="HEK616_31810"
     CDS             14284..14814
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024180.5"
                     /locus_tag="HEK616_RS15665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31810"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_261953566.1"
                     /transl_table=11
                     /translation="MSLGEPSPGVRVHGVAQGERAARPHLARSAIAHFACHGTSDSTDP
                     SQSRLILDDHATAPLTVSALGRVSLDHAQMAYLSVCSTAHAGSSDLIDEAIHLTSAFQL
                     AGFPHAIGTLWPIDDRLAAEIADSFYTHLTTGTPGRLDPALAATALHRTLRTVRDRYPA
                     TPSLWAAYLHAGA"
     gene            14953..15891
                     /locus_tag="HEK616_RS15670"
                     /old_locus_tag="HEK616_31820"
     CDS             14953..15891
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982346.1"
                     /locus_tag="HEK616_RS15670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31820"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_261957275.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.1e-07, bitscore:
                     28.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGMRVFVAGGTGVLGRRLVSQLLDRGHQVTATTTSAAKLGQLAQM
                     GADGVVMDGLDAASVGEAVATARPEVIVHQMTAISTAHAGKPDIKHPDRWFARTNRLRT
                     EGTDHLLAAAEATGVPHVVAQGYASWNGIREGGWVKSEQDPLDLLEGTAAHVGLKALSR
                     VEDVVLKAGGAVMRYGAFYGPGAIDDQVELVRKRKYPLVGRGTGYSSWVHLDDAASATV
                     LAVEQKATGVFNIVDDEPAPASDWLPHLAACAGAKRPMRIPVWLARLLAGDQAVVMMTE
                     GRGFSNAKAKRELGWQLRHPSWRQGFKEELA"
     gene            15900..16826
                     /locus_tag="HEK616_RS15675"
                     /old_locus_tag="HEK616_31830"
     CDS             15900..16826
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982347.1"
                     /locus_tag="HEK616_RS15675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31830"
                     /product="RNA polymerase sigma-70 factor"
                     /protein_id="WP_261957276.1"
                     /transl_table=11
                     /translation="MEKAEEFEELRPLLFSIAYRILGSVTEAEDAVQETWLRYEASSTP
                     PVSAKAFLSAVVTRISINVLHSARVRREEYVGPWFPEPLLSDQRSAELADSVSMAALLL
                     LERLTPLERAVFVLREVFEFGFPDIASAVGRSPAACRQLVVRARRHMHAGRPRFEADRR
                     EHEELALRFFDAFTEGDIDGVRELLAADVQMVADSGGKAPQWAGGFFGADHVSRVLAAL
                     VASFVRIGGIVEPHQMNGQPGAIFRDRDGKVIHTWTLDILDGQIQTIRTVSNPDKLGHV
                     GPVADAWAVLRETQQARRDDTHTYTTT"
     gene            16846..17436
                     /locus_tag="HEK616_RS15680"
                     /old_locus_tag="HEK616_31840"
     CDS             16846..17436
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517797.1"
                     /locus_tag="HEK616_RS15680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31840"
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="WP_261953567.1"
                     /transl_table=11
                     /translation="MTRIGIIIGSTRPGRNGDRVAQWVRDLAAEHAGGVGDFELVDLSD
                     HALPLLDEAIPAAQAPGRQPHTRRWAERIGSYDAYIFVTPEYNTAPPAALTNAIDYLYA
                     EWGGKPVAYVGYGVFGAVMAVQKLRAQAGVLRMADIGPQVALSLREDFVNFADFRPREL
                     HTAEVHRLVDELLAWAQALGPLRTAARTADHTA"
     gene            17458..18153
                     /locus_tag="HEK616_RS15685"
                     /old_locus_tag="HEK616_31850"
     CDS             17458..18153
                     /EC_number="1.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524784.1"
                     /locus_tag="HEK616_RS15685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31850"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_261953568.1"
                     /transl_table=11
                     /translation="MRITVFGANGPTGRLLTGQALAAGHQVTAVTRQPDSFPLHHDRLD
                     VVGGDALDPVAVEAAVAGREAVLSTLGVPAGKEPISTYSRGVANIVAAMTRHQVRRLAV
                     VSSSGVAPHPYSEGGLLFHHVLLPYVTRVLGKTLYDDMRRMEALVRASGLDWTIVRPSG
                     LFHLPSVTDYTVVEGHADGRFTARVDLAAGMLALLDDDRHVRTTVSVITTVDNPTLLHW
                     IRREALSKS"
     misc_feature    18289..18303
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.14"
                     /tool="antismash"
     gene            18506..20233
                     /locus_tag="HEK616_RS15690"
                     /old_locus_tag="HEK616_31860"
     CDS             18506..20233
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950189.1"
                     /locus_tag="HEK616_RS15690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31860"
                     /product="mycolysin"
                     /protein_id="WP_261953569.1"
                     /transl_table=11
                     /translation="MSRIRVTRPAALTALAGVGACLAVVVVPSAFAGTTTPTGSTCTIR
                     PAAKGSEAPLSCLGVTASLDHLPAVGEQATLTVNVRAQADVKHAGLSIQLPPAIRVTGN
                     DSGLTAPTTDAFGQRTSRTLALTPGTRTVKLKVKAVAAGPAQIQADISDIDRPDPRRAG
                     HDSLELTVGTSKGSSDKGVSVTKADAAPVHRPGSGTRKARPVTPKAGPAPVSSRASAAS
                     APASRRSAAATASNAQVCVGGTFRNRFQSAEGGSWNGKANRDEPVSNVNITLWGKPTAN
                     SGTQKLATGMTGNGDGRFNLCYAPSGSVISQAWVEFQTQAGRMWSVVDGSGRLYSTATY
                     SLNNISGNTSLGNVYANEGQSRAWHALDTLNKLWWNRGSTTNCWASSQQDGRCTPITVQ
                     WYPGSTDGTYWTTSDDKIHLADSDPDSEHTTVHEAGHALMGKLYKGWWPNVSNCSPHYV
                     NRTSSTSCGWTEGFANAVAFHTFNDTTYYWGNGSSMNLANDRATNGIDPGDACEARVAT
                     ALVDLWSKVDGGWTKSNSMMSRTWQSSFREYFVDDRPDYGLDSGSTARNILYNHTIQY"
     gene            20552..21175
                     /locus_tag="HEK616_RS15695"
                     /old_locus_tag="HEK616_31880"
     CDS             20552..21175
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091930.1"
                     /locus_tag="HEK616_RS15695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_31880"
                     /product="hypothetical protein"
                     /protein_id="WP_261953570.1"
                     /transl_table=11
                     /translation="MLPTRARIRRPFLVAATALTVGAATALTLGTTGAATAAESAAAAP
                     AATGAHAARHTVDEPLLKGSAKLKRQPGDNVHFTIDAHGFADKARGTFYVSHHIGKQWG
                     GYFKGRIDCLVTGGPVAVATGIVSESHFRGAPGMPTIGDLKGKRFGFTVLDDGKKDRLG
                     YSWAMDGLPMNSVGKCLGSAPFETLAKGDYTVHHWMPPRKPAKH"
     misc_feature    21728..21742
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
ORIGIN
        1 cgtgaggtca aagacagggg cgtcacagac agctgacgac caggaggcag acggttgctg
       61 ctgaggcggc gaacaccgcc agtgccacca cgtcggtgac gtcggcacgg cgcaaccgtc
      121 ggatccggaa gcgggtccgc atggtgtctc ccttcggcat gaggtcgtcg ctgcttgccg
      181 agctgagctt gcggtgccct ccgtcccagc cgccacgggc accgcggaac acgggacact
      241 ggaacgctca taccgtctct gacctgcggg aacgcgcact gcctggaacg ccgcaccggg
      301 acgcggcagg cgtcggccgc cgtgcaggaa cgtgcgagcg gcgtgtgggc cgggcggagc
      361 ggtgcgttgc cttgggtagg aagcgggcct ggacggccgg gtcgggcagt cccacgtgag
      421 catcgtcaca actgccgtgc cgcaggggtg cgttgtccag tccgggctag gacttgctgc
      481 atgacagggg ctggagttga ggtgatcgcc cgcggggcga gtgtgcaggg tccgagagga
      541 ccggtgttcg agggcgtgga cctggaggtg ccggcgggcg gactgctggc cgtgcacggg
      601 ccggccgggt ccgggcgtac ctccctgctg ctcgcgctcg ccgggcggat gcggttatcc
      661 ggcggggcca tccgggtcgg cgggtccgtc ctgcctgcgg agggccggcg ggtacgcgcg
      721 gcggtcgccg tcgcccgggc ggcgcccgcc gtcgctctcg aagggcgact gcgggtgacg
      781 gaggtgatgg ctgaacgccg cctcaccgga gccggggtga ccgagcggcg catccgcgag
      841 gcgttcgaga tcgtgggcat cgccccacgc aggtcggacc tggtcgagga cctcgatccg
      901 gtcgaggcgc tgctgctggc ggctgcgctg gccctcgccg agcgtcccgg cgccctcgtc
      961 gtcgacgacg tcgacgaagg cctgccgccc gacgcgcacg acagcgtgtg gcaggcgctg
     1021 gaccgggtca ggaacagcgg gcccaccgta ctggccgggt gcctccgcac gccgtcgccc
     1081 acggccggtc tcgtcgcact gtccttgccg cggcgcagcc gggaccgcct cccggccgac
     1141 acgaccgtcg cccgagagga cgccgacata tgaaggccgt caagctggca ctgctggaac
     1201 tccggcgctt ccgcggtccg gtgcgccgcc tggttcccgt actgctctgc ctggtgccgt
     1261 tgctgtacgg ggccatgtac ctctgggcga actgggaccc gtacggcaag accgaccgca
     1321 tgccggtggc cgtcgtcaac caggaccacc tggcgcatgc caagcagggc cgccgggtgg
     1381 acgccggtga tcagctggtg caacagctca aggcgtccgg caccttcgac tggcacttcg
     1441 tcggccggga cgaggcgcgg gacgggctgg agcacggccg ctacttcttc accatccaca
     1501 tcccgcccga cttcagccac aagatcgcca ccggcgccga cacccgtccc caacaggccg
     1561 gcatccggat cgaactcaac gatgccaaca actacatcgc cggcatcatg accgaagtgg
     1621 tgcagaccaa gctgcaggac cagatcaact ccgccaccca tgccgcctat gtgcgcagca
     1681 tctacggcga actgtccgcc gtacgcgcca agttgaccac cgcctccgac ggcgcacacc
     1741 gcctggtggg ggccacccgc gtggcccagc agggcacgtc cacgatcacc tcggccacct
     1801 ccaccctgca cgacggggcc tttgacgtcg catccggggc acggcagatc gcccgggcca
     1861 caggacagat cgacgacctc accggccgcc tggaccaggc cgccgccgac cggcttcccg
     1921 gcgccgcctc cgcgctggtg agcaccgccc ggctgaccgc cgacggtctg gacgccgtgc
     1981 acaccgccac caccgccacc cgcaagggca cctcccgggc cgtggccgac ctcaccgctc
     2041 tcgccaccac gcacccggaa ctacgcgacg accccgtcta ccgccgggcc ctgggccacg
     2101 cccgtagcct ggactccacc gccaccgctc tcgacggccg ggccgccgcc gcggagaaca
     2161 acgcccgtcg gtccctcgac gaagccgagc gcctccagga cgacgtcggc tcactccaac
     2221 gcgacgtact ggccctgcac accccgctcc gcctcgtcga cagcggttcg cacagcgcgg
     2281 ccgacggcgc gcacggcctc gtcgcagggc tcgccaccct ggaaaagggc tccggtgccc
     2341 tgcacaccgc tgccgagcag gcgcacggcg gcgcctcgga agtctcccgc accgtggacg
     2401 acggactgca caaaatcccc cgcaccagcc ccgaccaggt cgcgcacgcc gccgaggtac
     2461 tgggcacgcc cgtgcacatc gaccggacga acctgcaccc ggccggcgtc tacggccgag
     2521 gcctcgcacc gttcttcttc ggcatcgccc tgtgggtgtt cggcctcttc gcctacctgc
     2581 tgctgcgccc cctcaacacc cgtgccctgg ccgggcgggt cagcgccttc accacggccg
     2641 tcgccggatg gctaccggcc gcactgctcg gcgccgtggg ggcactggtg ctctacggcg
     2701 tcgtcgacct gaccctcgga ctgaaccccg tccacggctt ctggacgctc gcactcctgg
     2761 tcaccgcggc ggcggcgttc gtggccgtcg accactgtct gcgcaccgtg ttcggggtgc
     2821 ccggcgacgt cctgtcactg gtcctgctca tcctgcagct caccgcctcg ggcggcctct
     2881 acccgctgcc caccgaaccg gccttcttcc aggtcctgaa cccgttgctc ccgatgacct
     2941 acctcgtcga cggactacga gtgaccgtct ccggcggcct caccggaaat ctgctgcggg
     3001 acttcgcggt cctcctcgcc tgcaccgccg gtttcctggc agtgaccgcc ctcgccgtac
     3061 ggcggcaacg ggtgtggacg gtcggacgcc tccatcccga cgtttcgctg taggggcgtg
     3121 cgtcgtcgac cgacgtgggg tgcgggcatg gctgcccgtc ggtcggtcgc ccccgggccc
     3181 ggcctcggcc agacggccag gcggccagcc gggcaggccg tcaggcggaa aggccgagcg
     3241 tggtcaggcg gtcagggtcg gtgaggatgt cgagtccggc gatacggccg tcccggatgg
     3301 tgaacgacat gaccgacagc ggtcggccct cggcgaagga gacgacgccg ggcgtgccgt
     3361 tgaccagcac cagacgcgcc tcggccgcga agcgggcgaa ggtgatggcc tgggacgcca
     3421 cgtcggccgc accgcgccgc aggacgctcg ggacgagcgt gccgccgtcg gagcgcgcga
     3481 ccacatcggg gtcgaggacg gccagcagcg cttcgaagtc gccaccgcgg gaggcggcca
     3541 ggaaggcgtt gacgacgtcg cgcttgcgcg tgaggtccgt gtccgccgcc ggggcggcgc
     3601 cctggacccg gcggcgggcg cggctggcga gctgccgggt ggagaccgtg gtccggccga
     3661 ggatgggcgc gatgtcgtcg aagggaacgt cgaacatgtc gtgcaggacg aaggcgagcc
     3721 gctcggccgg ggcgagggtc tccagcacga tcatgagcgc gatgcccacc gagtcagcga
     3781 tcaggatctc ctgctcggga tcgacccggg ccagcgcggt gaccaccggg tcgggcagcc
     3841 gcaccgatcc gtcctgctcg ggcagcggat cctcgcggcg cgaggtacgc gagcgcagca
     3901 tgtccaggca gatccggccg acgaccgtgg tgagccaggc ccccaggttc ttcacctcgc
     3961 tcacgtcggt gcggctgagc ttgaaccacg cctcctggac ggcgtcctcc gcctcggcga
     4021 gcgatcccag catccggtag gccaccgcgc gcagccccgg ccgctccacc tcgaagcggt
     4081 cggccagaag aaagttctcg ctcacctgcc acacccccgt gtccggatcc gtcggtccgg
     4141 agaagacgct aaccgatcac cgggaaagca tgggatgaat accgcaatcg gcagcggtgc
     4201 cggagtgcgc ggcccgggta ccgaccgagg ccggcactcg ggtcgcccaa gcgccggcgg
     4261 gtggctggga ggtcggtggc ctggccggga tccgttgggc aggatgctcg ggtggcgaag
     4321 tcgtgggcgt gtgaggcatg tggggtgcgg ctcccggggc gctcgcggtc cggggcggac
     4381 ggcagacagc gcgggggccg gccggcgcgg tactgctccg acgcctgccg ccagcgcgcg
     4441 ttccgggagc gggcggccgc ggcgtcccgg gccgccccgc gcgcggaact gccgggccgc
     4501 ggactaccgg tctcgctcga tgcgttcgtg ggacgcgaac gcgagttggc gcgcttgcgt
     4561 acgctgctgc ggtcgtcgcg actgctgacg ctgaccgggc ccggcggagt gggcaagacg
     4621 cggctggcgg tcgagctcgc gggcggtgtg cgcggcggac gcgcgggacg tgcccagttg
     4681 gtggagctgg ccgggctgca cgacggtgag ctgctgccgc agaccgtggc cgccgccctc
     4741 ggtgtgcggg agcgcgccgg ccggacggga acggaggcgt tggtccgcgc cctggagaaa
     4801 cgcagcaccc tgctccttct cgacaactgt gagcatctgg ccgagccctg cgcggtgttg
     4861 gccgcggcac tcctcacccg ctgccccggc ctgcggatcc tcgccaccag ccgggagccg
     4921 ctgcgggtgc ccggcgaggt ggtgttccgc gtcggcatcc tgtcgctgcc gccgggcccc
     4981 gcaggtgctg gcggggatca gcacggagac cagggcaccg acccgctcct ccggtcggag
     5041 gcggtccggc tcttcctgga gcgcgcccgc acctgccatt cggggttcga gcccacgccc
     5101 ggggacgtcc ggaccgtggc cgagatctgc cgacggctgg acgggctgcc gctggccatc
     5161 gaactcgccg cgggccgtat ggcagcgctc ccgcccgccg ggatcctgcg cggactggac
     5221 gatcagctgt ccctcctgac cgacggcagc aggacgggac cggggcgcca tcgcgagctg
     5281 ggcgccacga tcgactggag ccatcgcctg ctggatcccc tggaacgggc ggtcttccga
     5341 cggctgtcgg tgctcggcgg cgggttcgac gcggagagcg ccgccgcggt ctgtgcggat
     5401 tgcgctacgg ccgccgacgg tgtcgaggga tgcgtgggtt gccgcgacgg gcggtgctgc
     5461 gtacggcgga aacaggtgtt gcccgtgctg tgcgccctgg aggccaagtc cctgatcgtg
     5521 cgggtgcacg gggacgcgcc gggcacggcg aggttccggc agctcgcggc gatccgggcg
     5581 tacggcatgg accggctcgc cgaggccggg gaactaccgg cggtctggga ccgggcggtg
     5641 gaccggctgg ccgaacaggc ggctgagggc tccaccatgg tcttcccgga cggcgccgcc
     5701 ctgccgctgg cccgggaaca ggagaacctc gcggcggccg tggcccgttg cggcgaacgg
     5761 agcgacccac ggcacaccga gctcgccctc gcattggccc gactccacta ccagcaggag
     5821 cagttgacgg cagcccggac gctgctgacc gaggtgctgg cgcggaccac gtacggctcc
     5881 cgggaccacg gtgcggcgtt ggcgctggcc gcccgcgcgg cctgtcagca ggacgaccgg
     5941 tcggcggcgc tcgccttcgc ccgggaagcg gtcgccgtgg aacgcgccgg cccaccgcac
     6001 cccggccggc tggccaacgc cctggacgcc ctggcggccg cgcacctgtg ccgcggtgcc
     6061 taccacgagg ccgtcgccgt cttcgccgag tgtgtggcgg tggtccgtac gctggaccgc
     6121 ccgctggaca tcgccgtgtg cgggcaccac ctcgcctggg ccctgctcca gacgggcgac
     6181 acggcgcagg cggccgcact gatggagaaa tgcctccccg tcctggaatc cggcgctcca
     6241 ccggggcagg cagcggccgc tctccacacc tccggcgcga tccagctggc gctggggaac
     6301 tgggacgcgg ccgagaacag gttcgccgag gtgctggcaa aggtgccgga cggtgagagc
     6361 ctccacgcgc tctatccggt ggagggcctg gccatcgtgg cggccgaacg cggcgcgccc
     6421 gaacgggcgt tacggctcta tgccgcggcc gccgcggcgc ggcaacgcac cgacgccgaa
     6481 ccggaagcga gctggcggac gacggtggag gccgccgcgt cccgggccag ggagcggctc
     6541 caccccgcac gggtcgacgc ggcgatgacg gccggccgcc gcctgtacgg ggaacgactg
     6601 ctgtcctacg ccctacgcga caacgcatcg gccgaccgct cgacgcacgc gaaccacgat
     6661 gatcccaccg acgtcgcgca cccgacccca accgaaccga tcagctaccc cgttacccaa
     6721 cttctgctca caccacgaga attgacggtc tcgcagctgg tcgccgaggg gatgaccaac
     6781 cagcagatcg ccgcgcagct gggcctgtcc aagagcacgg tcgccagtca tctcgaccgg
     6841 gtccgggaca agctgggcgt ccgctcccgt acgcagatcg ccgtccgggt ctccggacgg
     6901 gcgggtggtc cgggggctga gtcggtgtag ctggaggtgg ctgagggtag ccgaggcgcg
     6961 gtcggcccga agggcggtcg ggccgaggga cgtctgaggg cgccgcccgc cacggccagg
     7021 cggcggaggg gggtagggcg gtagggcggt ggtgcatcgg gctgctccca aggacggcgg
     7081 ccacagagcc aggagtcggt agctcgctga caactctccc tgccctgacg cccgttgccc
     7141 tcagggttca accctgggcg gtccccgagg caaccctgaa agccccctgc ctcctgccag
     7201 acacatcctg gtccccgcgg gtgtgcgacc ggcagctcgg cgaccggcgc ggctccgtcc
     7261 gtgatccgcc ggacaggccc ttcacctccc tcgtggggtt tcgtcacgcc cgtaactggt
     7321 cggtcattcg acggatgtgc gcagtcgacc tgaccacgga ggctgatctg agccgggaga
     7381 gtgcttcctc cccggcgctc tccccaacgc catcaccccg caaaggagac gcgatgcggt
     7441 acgccgacga gaccggcccg gacgatgctg ccggaacgca gcacggttca cgcaggtcct
     7501 tcatcaggtc gacctccgcc ggagtgacgg cagtggcgct cggcgcgagc gtggccgcct
     7561 ctgccggccc ttcggcccaa gcagcggagg cggccgcccc gggggcccgg cgcggcaccc
     7621 gtccgctcgc cgtcaccccg gcctgctcgg gccaggaaac accggcatcc atcgagggcc
     7681 cgctgttcaa gcccaattcc cccgcgcgca gcgatctgat cacgcctgcg atccaaggcg
     7741 tacggctcga cctcagcggt gtcgtgtacg acacgtcctg caagcccctg cccgaaacgc
     7801 tcatcgagtt ctggcagtgc gaccagaacg gcgactacga cacctcgggc ttctccctgc
     7861 gcggccacca gtacaccgac agcaggggtg cctaccaact ccggaccatc atcccgcggg
     7921 actactgggg acgttggggc caacgtgccc cgcacatcca cacccgggtc caggcctccg
     7981 gcggcccggt gctcatcact cagctgtact tccccgacag cacccaggcg tacggacggg
     8041 acttcgccgc tctcaacgcc gccgaccgac tcctcaaccg cgcatgcacg atcagcctca
     8101 ccggtcagga gggcggccgc tacaccggcg ccttcgactt cgtgatcacg accacggtgt
     8161 aggcgccggg ggccaagttc gtcaccacca cgatgcaggt agcggggccc gagttcgtca
     8221 gcaccgtccg atggcccgac gggtccgacg cggccttcgc cgtccccgta cccaccctca
     8281 tctcccgtcc cccttcagac aaggaaattc gtatgccctc gcacagcccc ttcccccggc
     8341 ggcgatccgt ccgggtctcc ctgctggcgg ccctcgtcgc caccgtggtc accgggagcc
     8401 tggtattggt cggccagagc ggtgatccga cgactccgac cgcagcctcc gctcccgcgg
     8461 catccctcgc ccccgccgcc ccgcacgcgg gggcgtggca ggcaaccccg gtgcccgtca
     8521 agaaggggga tctgacggcc gtcgccgccc tgagcgacaa acaggcctgg gccgtcggct
     8581 accggctcaa gagcgccacc tcgctcgagg cggtcgcact gcgctgggac ggtaagacct
     8641 ggacccagga atccaccctc cccgacaaca gcttcccgca agcgctcgcc gtccgttcgg
     8701 ccaccgacat ctgggcggtg ggcagcgcct cggcccattg ggacggcacc aagtggaccg
     8761 cgtaccagct ggacaaggac ccctccggcc acgtcgtccc ggatgccgtg gcaacaacct
     8821 ccgacgggaa agtgtggacg gcgggccggg ccatgggccg gtcgatcaag gacggcgtgc
     8881 cggccgtcca gtcctgggac ggcaaggcct ggcaccgcca gtccctgccc gatgtcggca
     8941 agggtgaact cagcggcatc acggcggtcg cgcccgacga catctgggcc gtgggagcgg
     9001 cctacgctcc cgatgagaag tcccagcagt cggcgctgct gctgcacttc gacggcagca
     9061 attggcggcg tgttgcggcg cccggcccgc agaccaccca caactggctc ggcgggatca
     9121 ctgccctctc ggcagacgac atctgggcgg taggcggaag caccaccggc agtacggagc
     9181 ggccgctcgc cgtgcactgg aacggcagca cctggaccac ggccaggaca ccggacgtgg
     9241 ccgacggccg actccgcggc gtaggcaaaa caggcaacgg cgatctgtgg gccctcggcg
     9301 ggaagggggc ggcccccgtc gctctgcact ggaacgacca gcacgaccag tgggagaaga
     9361 ccactgcgcc ggacctcgtc atccgcagct tcaccaccgt gccccacagc gccgacctgt
     9421 gggccaccgg aatctccccc cacggcgacc tcattccggc gatcacccgc ctcaagaact
     9481 gataccgggt actgcgtggg ccgccggcac tggcgcacag cggggttgtc cctccccgcg
     9541 taagcccgct gggaggctcc ggacggagcg gagtaacttg ctcaactcag ctcacagcaa
     9601 aacggattgg gttcgtccaa tgtgccgatc cgcttccgac cagcgggtat gttccccgct
     9661 ccgctccacc acgaccggca actaccaccg catccgtaaa aaaattcgat catggcgcgg
     9721 ttgttcggtg ttagcttgtg cccgagcagt cggatgactg ccgatttata cccatggagg
     9781 ctgatatgga agagcagaac gagctgtcga ccgtggagcc gtacgcagcc ccgatgctgg
     9841 ttgaggtcgg cgagttcaac gaggacacgc tgggcttcat cggctggggc aaggacatct
     9901 tcggccacta cggcggctga ccgaccgtca ccagctgatc gacagctggc tgaccctcaa
     9961 cagctggatt tcgccagctg actttcagga gtaagcacag atgaccggtg ctgggttcgt
    10021 ggtcctgccg gatgcggcgt ccgcggtaga ggtacgtgcg gcggtgccct ggccggcgcc
    10081 ccaggtgctc tcgcacgcct ctggacgtcc gtggctggtg ggcaggtggc tgcctgacgc
    10141 ggttcaggtg gccacggcgg gcccggtacg ggtggcggtg atcgggatct gcccggtcac
    10201 cgccacgcgg ttgtccgaac tcaccgcccg tatccgcacc agcgccgaca tcgacgccct
    10261 ggcggcggcc ctgccgggat cgtgccacgt catcgcctcg ctcgacggac aggtccgcgt
    10321 acaaggcagc atcaccgggc tgcaccggat cttccacacc cacctcaacg gcctgcccgt
    10381 cgccgccgac cgcgctgacg tgctggccac gatgaccggt gccggaatcg acgaacgcgc
    10441 cctggcccta cgcctggcct gcggcggact cgttcccccg ccgctgagcg acacacccct
    10501 gtggtcaggc atctccccac tgcccgcgga ccactacctg ctactgcagg accaacaagc
    10561 ccggcaggtc cgctggtggc ggccacccac ccccgacctc tccctcgccg cgggcgcaac
    10621 ggccctgcgc gaggtgctgg agacggccat ggccggccgc gcgccctccg cgggccggct
    10681 gagcagcgac ctgtccggcg gcatggactc cacctccctg tgcttcctcg ccgcccgcac
    10741 cacccccgac ctgctgacct tccgctgggg cgaggccgag gccggcaacg acgacgcggc
    10801 cttcgccgcc cactccatcg acgccctcga ccgggccgag cacctcgtca tacccccaac
    10861 cgacctcccg gccctcttca ccgacccggc caccacgacc gagttggaag agccctaccc
    10921 gttcgtccgc accggcgcac gtacccgcca caccgcccgg ttgctcgccg accgcggagt
    10981 ccaccgccat ctggccgggc acggcggcga cgaattgttc acccccttcc ccggctatct
    11041 gcacccgctg ctgcggcgcc gccccgtcac cgcgctgcgg cacgtccgcg gttacgccgc
    11101 cctcaagcgc tggccgctgc tgcacactct ggctgcgctg acccgccccg gtcaccaggc
    11161 atcgtggtgg cgcgcccagg ccgaccacct caccgaccca ccgtcgcgca agcgccgccc
    11221 cagtctgggc tggggtctgt ggccgctgcg cgccccggcc tgggtcacca ccgaggccat
    11281 cgagaccgcc cgcgccggcc tcggccggac cgcagcccag gcagagccgc tctccaccga
    11341 cctcggtcag caccagaccc tgctcgccgt acgcatcgcc gccccctggt accggctgct
    11401 ggcccgcccg ttcgccgacg ccggcgtcca gctcgactcg ccgttcttcg acgaccgcgt
    11461 cgtcgaggcc gtgctccggg tgcgcaccca cgaacacgcc gggccctggc actacaaacc
    11521 cctgctcgcc cacgccatgc gcggcatcgt ccccgacacg gtgctgggcc ggtccaccaa
    11581 gggcgagttc agcgaagagg ccagcaccgg cctccgccgc aacctgcccg ccctgctgga
    11641 gctcttcgac gattcggccc tggccgccca cggcctcatc gacccggccg tactgcgcac
    11701 ccaactgctg gccccccagg cgaccaacgc catgaacatc gccctggaac ccctcatcgg
    11761 ctgcgaaacc tggctgcgcg cagccacccg gcccaccgca cccacgcccg ctcgatccac
    11821 gcccatccga cccacccccg cccgaaggac gaccgacacc catgcacctg caccctgacg
    11881 tggtctccac cgacaccgac gacggcaccg tgctgctcaa ccaacgcacc ggccgctact
    11941 ggcagctcaa caccaccggc gcccacgtac tgcgcgaact cctcgccggc cacaccccga
    12001 acgacatcgc cgccgacctc gccgcccggc accacatcga ctccacccga gccgaacagg
    12061 acgtcaccgc ggtcctcacc cagctgcgca ccgccgacct ggtgaccaca tgagcctccc
    12121 cgttgccctg tccgaacgac cccgcctgcc cctgcaccgc cgcccggtac ccctgctggc
    12181 cgtcgccgcc gcccgcctgc tggccaagct gaaaccggcc cgcctgcgcc ggatcctgga
    12241 attcgcccgc cgcggcgccc gacctgccac cgccgaacag gccctggccg cccgcgaagc
    12301 ggtcgtcgcc gtcagcctgc gctgcgccgg ccagggctgt ctgcaacgct ccatcgccac
    12361 cgctctgctc tgccgcctgc gcggtgcctg gcccacctgg tgcaccggtg tgcgcaccca
    12421 cccgttcgcc gcccatgcct gggtcgaggc cgacggccac cccgtaggcg agccccaccc
    12481 caagggccac ttcaaaccac tgatcgccgt gccacccctc tcgccggcgg gggagtagct
    12541 gagcgccacc cgtcagcgac tcaggcgcgc gttgacccgg gcggcctggc gcgtcaggtg
    12601 gtcgcgctcg gcgaggttgg gtgccttgtg ggccgcctcg gcgtacagcc gtgccgcagt
    12661 cgccaagtcg ccgtcgcact cgtggaggta ggcggccacc gcggtgtggc ggggcagtgc
    12721 gtcgtccagc tccgcgagcg ccgccaggcc ggcgcgcggt ccgtccgcct cgcccacggc
    12781 gaccgcgcgg ttgagccgga cgaccgggct gtcggtcagg cgcgtgagct cgtcgtacca
    12841 ctcgacgatc tgcacccagt cggtctcctc ggcggtgggc gcgtcggcgt ggagggcggc
    12901 gatggcggcc tgggcctgga actcgcccag ccggtcgcgg gcgagggccg cctgcaggat
    12961 ctccacgccc tcggcgatca acttcgtgtc ccaccggccg cggtcctgct cggcgagcgg
    13021 caccagactg ccgtcgggcg cggtccgggc ggctcgtcgg gcgtggtgga gcagcatgag
    13081 ggcgagcagc ccggccactt cggggtggtc gatcgcggcc gcgagctgcc gggtgagccg
    13141 gatggcctcg gcggccaggt cgacgtcgcc ggagtagccc tcgttgaaga ccaggtagag
    13201 gacgcgcagc acggtggcga cgtcgccggg ccggtcgaac cttcccccag ctctcgaatg
    13261 cgctcgagca ggggatagcc caacatcgga gacggtgcgc ttgccccggc tgatgcgctg
    13321 cgccatggtc gcctcgggca ccaggtaggc ctgggcgatc tggcgggtgg tgagcccgcc
    13381 gacggcgcgc agcgtgaggg cgaccgcgga cgcaggtgtc agcgacgggt gcgcgcacag
    13441 gaaatagagc tggagtgtgt cgtccgccgc gggcacgggc ccggacgccg gctcctcctc
    13501 gacgcgttcc tcacgccggc ggcgggctgc gtccgcccgg gtcgcgtcga ggaacttgcg
    13561 ccaggccacg gtgaccagcc agcccttcgc gtcccgcgga gggtcggccg gccagacgcg
    13621 gaccgcctcg acgagcgcgt cctgcaccgc gtcctcggcc gccgcgaagt cggctccgcg
    13681 gcggacgagg acggtgagca cactcggcgt gaggctccgg atcagggcct cgtccatctg
    13741 ggacacctgc ggggtcactc cgtgatggtg gggggcgcgg tcaggaacgg gcgcagctcc
    13801 agccactcgt ggatcggctt cccgcccgcc ccgggggcgg ccgacagttc cccggccagc
    13861 tcgacggcgc gctcgtagct gtcgacgtcg atcaccatcc agccggcgat gaggtccttg
    13921 gtctcggcga acggaccgtc ggtgaccggc gggcggccct cgccgtcgta ccggacccac
    13981 ttcccctcgg gggcgagcgc ctgaccgtcg acgaactcgc cggtcttctc cagccgggcc
    14041 gcgaaatcat tcatgtactg cacgtgggcc gagatctcct gcggcgtcca ctgatccatg
    14101 ggcacgtcgt tgaccgcagc cggagcgccg cggtagtgct tgagcagcaa gtacttggcc
    14161 atggtgtctc tcctcgatgc tgttgcgacc cattgtggcc gcgttcaatg ctgggacgga
    14221 gccggccacg cgttctcggc atcgccgtca gaaatttttt tgggctcttg tgggggctca
    14281 tcgatgagcc tgggtgagcc gtctcccggc gtccgggtcc acggcgtggc gcagggggag
    14341 agggcggctc gcccacacct cgcacggtct gccatcgcgc acttcgcctg ccacggcacc
    14401 agcgacagca ccgacccctc gcagagccgg ctgatcctgg acgaccacgc caccgccccg
    14461 ttgaccgtct ccgccctcgg ccgggtcagc ctcgaccacg cccagatggc ctacctatcc
    14521 gtctgcagta ccgcgcacgc cggcagctcc gacctgatcg acgaggccat ccatctcacc
    14581 agcgccttcc aactggccgg attcccccac gccatcggga ctctgtggcc gatcgacgac
    14641 cgcttggccg ccgagatcgc cgactccttc tacacccatc tgaccaccgg tacgccaggc
    14701 aggctcgatc ccgcactggc cgccaccgcc ttgcaccgca ccctacggac cgtgcgcgac
    14761 cgctacccgg ccaccccttc cctgtgggcg gcatacctcc acgccggcgc ataaccgggc
    14821 ctcgttgggc gcgaactccc gtagacgtcg ctcctacgcg accacatttc ccatcgtcct
    14881 gccccccatg tcacaaacgg cccggctgtc ttgtcttgtg tggtgaagac agacgctcac
    14941 gtcaggaagg tgatgggcat gcgggtgttc gtggcaggcg ggacgggggt cctggggcgg
    15001 aggctggtgt cgcaactcct ggaccgtggc caccaggtga cggccacgac cacgagtgcg
    15061 gccaagctgg gacagctggc gcagatgggc gcggacggtg tggtgatgga cgggttggat
    15121 gcggcgtcgg tgggtgaggc ggtcgccacg gcgcggccgg aggtgatcgt gcaccagatg
    15181 accgcgatct ccactgcgca cgccggcaag cccgatatca agcatccgga ccgttggttc
    15241 gcccgcacca accggctgcg caccgagggg acggaccacc tgctggcggc ggccgaggcg
    15301 accggtgtgc cccatgtcgt cgcgcagggg tacgcctcgt ggaacggcat ccgcgagggc
    15361 gggtgggtga agagtgaaca ggacccgctg gacctgctgg aggggacggc ggcgcacgtg
    15421 gggttgaagg cgttgagtcg ggtcgaggac gtggtcctca aggccggcgg tgcggtgatg
    15481 cgctacggcg cgttctacgg gccgggggcc atcgacgacc aggtcgagct ggtgcgcaag
    15541 cggaagtatc cgctggtggg gcggggtacc ggctacagct cgtgggtgca tctcgacgat
    15601 gcggcgagcg ccaccgtcct ggctgtggag cagaaggcga cgggcgtgtt caacatcgtc
    15661 gacgacgaac cggcgccggc gagcgactgg ttgccccacc tggcggcgtg cgcgggcgcg
    15721 aagcggccga tgcgcatccc ggtgtggctg gcccggctgc tggccggtga ccaggcggtg
    15781 gtgatgatga ccgagggacg tggtttctcc aacgccaagg ccaagcggga gctcggctgg
    15841 cagcttcgtc atccgtcgtg gcggcagggc ttcaaggagg agctggcgtg accggaatga
    15901 tggaaaaggc cgaggaattc gaggagttgc ggccgctgct gttctcgatc gcctaccgga
    15961 tcctgggcag cgtgaccgag gcggaggacg ccgtccagga gacctggctg cgctacgagg
    16021 cgtcctcgac accgccggtc tcggccaagg cgttcctgtc cgccgtggtc acccgcatct
    16081 cgatcaacgt gttgcactcg gcccgcgtcc ggcgcgaaga gtacgtcggg ccgtggttcc
    16141 ccgagccgct gctgagcgat cagcggtcgg cggagttggc cgactccgtg tcgatggcgg
    16201 cgctgctcct gctggagcgg ctcaccccgc tggagcgcgc ggtgttcgtg ctgcgggagg
    16261 tgttcgagtt cggcttcccg gacatcgcct cggcggtggg ccgctcaccg gccgcgtgcc
    16321 gtcagctggt ggtacgggcc cgccgccaca tgcacgccgg ccggccccgg ttcgaggccg
    16381 accggcgaga gcacgaggaa ctcgcgctgc ggttcttcga cgccttcacc gaaggggaca
    16441 tcgacggggt gcgggaactg ctcgccgccg acgtgcagat ggtcgcggac agcggcggca
    16501 aggccccgca gtgggccggc ggcttcttcg gcgccgacca tgtgtcccgg gtgctcgccg
    16561 ccctcgtcgc gtcgttcgtc cgtatcggcg ggatcgtgga accgcaccag atgaacggcc
    16621 agcccggcgc gatcttccgc gaccgggacg gcaaggtcat ccacacctgg accctcgaca
    16681 tcctcgacgg gcagatccag acgatccgca cggtgagcaa ccccgacaag ctcgggcatg
    16741 tgggccccgt agcggatgcc tgggcggtcc tgcgtgaaac acagcaggca cgccgggacg
    16801 acacacatac atacacaacc acctgaacaa aaggaccggc ccaaaatgac caggatcggc
    16861 atcatcatcg gcagcacccg ccccggccgc aatggcgacc gggtggccca atgggtacgg
    16921 gacctggccg ccgaacatgc aggtggcgtc ggtgacttcg agctcgtgga cctgtccgac
    16981 cacgcgctgc cgctgctcga cgaagccatt ccagcggccc aggcgccggg ccgccagccg
    17041 cacacccggc ggtgggccga gcggatcggc tcgtacgacg cctacatctt cgtcactccc
    17101 gagtacaaca ccgccccgcc cgccgccctg accaacgcca tcgactacct ctacgcggag
    17161 tggggcggca agccggtcgc ctacgtcggt tacggcgtct tcggcgcggt catggcggtg
    17221 cagaagctgc gcgcacaggc gggcgtgctg cggatggcag acatcgggcc ccaggtggcg
    17281 ctgtcgctgc gcgaggactt cgtgaacttc gccgacttcc ggcctcggga actgcacacg
    17341 gcggaggtgc accggctggt cgacgagctg ctggcgtggg cgcaggctct cggcccgctc
    17401 cgtacggctg cccggaccgc tgaccacacc gcgtagcaac cagggagaac agtcgtcgtg
    17461 cgtatcaccg tcttcggagc caacggcccc accggccgcc tcctcaccgg ccaggcactc
    17521 gccgccggac atcaggtcac cgcggtcacc cggcagccgg attcgtttcc cctgcaccac
    17581 gaccggctcg acgtagtggg tggcgatgcg ctcgatccag tggccgtcga agccgccgtg
    17641 gccggtcggg aggcggtgct ctcaaccctc ggggtccccg ccgggaagga gcccatcagc
    17701 acctactcgc gcggagtggc caacatcgtc gcggcgatga cccggcatca ggtgcgccgg
    17761 ctcgccgtgg tcagctccag cggggtcgct ccgcacccgt actccgaggg tgggctgctg
    17821 ttccatcacg tgcttctgcc ctacgtgaca agggtgttgg gcaagacgct ctacgacgat
    17881 atgcgccgga tggaagcgct ggtgcgagcc agcggtctgg actggacgat cgtgcgcccg
    17941 agcggtctgt tccacctgcc gtcggtcacc gactacaccg ttgtcgaggg ccacgccgac
    18001 ggcaggttca ccgcccgggt ggacctggcc gccggcatgc tggctctgct ggatgacgac
    18061 cgccatgtgc gcaccactgt cagcgtcatc accaccgtcg acaaccccac cttgctccac
    18121 tggatccgcc gggaagctct ctccaagagc tgagccgatg cgtacgcacc gccgtgcgca
    18181 cgtggtgggc gaggtggcga cgtctgcggt cgggggccgg agccctcagt gtgatccaca
    18241 tgcacggagc gtgccccatc tgcccttcgt tcgcgggtaa ttcgcacctg atccacattt
    18301 tcctccttga gcgatgacat gcgcaggccc tcggtatatg gttcggccac tgtcacccag
    18361 ggtggtgctc tggccaacgg ttgatccgat ggttgaacgt cgccgtgcct ggggtgcagt
    18421 gccctacccc cctcaagctc tgcccgcgtg caccggaccc ggtcatgacc gaccgggtcc
    18481 gtgcgcgccg ctgaaaggca tgcccatgtc ccgaatacgg gtcaccagac ccgccgccct
    18541 gaccgcgctg gcaggcgttg gagcctgtct ggcggtcgtc gtcgtgccgt ccgcgttcgc
    18601 gggtacgacc accccgaccg gcagcacctg tacgatccgt cccgcggcga agggctccga
    18661 ggcgccgctc agctgcctcg gcgtcaccgc ttctctcgac cacctgcctg ctgtcggcga
    18721 gcaggccacc ctcaccgtga acgtccgggc gcaggccgac gtcaagcacg ccgggctgtc
    18781 gatccaactg ccgcccgcga tccgggtgac tggcaacgac tccggactca ccgcacccac
    18841 aacggacgcc ttcggccagc gcaccagtcg gacgctcgcc ctcacccccg gcacccgcac
    18901 cgtcaagctc aaggtcaagg ccgtcgccgc cgggcccgcc cagatccagg cggacatcag
    18961 cgacatcgac cgtcccgacc cgcgccgcgc cgggcacgac tcgttggaac tcaccgtcgg
    19021 cacgtccaag ggctcctccg acaagggcgt ctcggtcacc aaggccgacg cggccccggt
    19081 ccaccgcccc ggctccggca cccgcaaggc gcgcccggtc acccccaagg ccggcccggc
    19141 tcctgtctct tcccgtgcct cggctgcctc ggccccggcc tcccggcgct ccgccgccgc
    19201 gaccgcgtcc aacgcccagg tctgcgtcgg cggcaccttc cgcaaccgat tccagtccgc
    19261 cgagggcggc agttggaacg gcaaggccaa ccgggacgag ccggtcagca acgtcaacat
    19321 caccctgtgg ggcaagccga ccgccaacag cggtacgcag aagctcgcca cggggatgac
    19381 cggcaacggc gacggcaggt tcaacctctg ctacgccccg agcggctccg tcatctccca
    19441 ggcctgggtg gaattccaga cccaggccgg ccgcatgtgg tcggtggtcg acggcagcgg
    19501 ccgcctctac tccaccgcca cgtactcgct gaacaacatc tcgggcaaca ccagcctggg
    19561 caacgtgtac gccaacgaag gacagagccg tgcctggcac gcgctcgaca ccctcaacaa
    19621 gctgtggtgg aaccgcggtt ccacgaccaa ctgctgggcg agcagccagc aggacggccg
    19681 ctgcaccccc atcaccgtcc agtggtaccc cggctccacc gacggtacgt actggaccac
    19741 cagcgacgac aagatccacc tcgcggacag tgaccccgac tccgagcaca ccaccgtcca
    19801 cgaggcgggc cacgccctca tgggcaagct ctacaagggc tggtggccga acgtgagcaa
    19861 ctgctcgccc cattacgtca atcgcacctc ctccaccagc tgcggctgga ccgagggctt
    19921 cgccaacgcg gtggcgttcc acaccttcaa cgacaccacg tactactggg gcaacggcag
    19981 ctccatgaac ctcgccaatg accgcgccac gaacggcatc gatccgggcg acgcctgcga
    20041 ggcccgcgtt gccaccgcgt tggtcgacct gtggtccaag gtcgacggcg gctggacgaa
    20101 gagcaacagc atgatgtccc ggacctggca gtccagcttc cgtgagtact tcgtcgacga
    20161 ccggcccgat tacggcctgg acagcggctc gacggcccgg aacatcctct acaaccacac
    20221 catccagtac tgacacagac actgactgct gtcagctgga gggacccatg gaccgggccg
    20281 caggcggccc ggtccatgcg cgtgttccca ctgattccca cggaaggtcc cgtgtgcgtc
    20341 gtgggcagcg gttctggggc cggccaggcc cttcagggcc cccgcatcgg cctgggggac
    20401 cgctcctcct tccgccgtgc ggcggaggcg taccggcctg tggtgcgatg tggcgatacg
    20461 ggtgcggacg gcaccgtggt gagcagccgg gaacctcccg ggtgacggac tcgatgacgg
    20521 tccgcccacg ccacttccgt tggaggaagc catgctcccc actcgcgccc gcattcgccg
    20581 ccccttcctc gtcgccgcca cggccctcac cgtcggcgcg gcgaccgcac tgacgctggg
    20641 caccacgggc gcggccaccg cggccgaatc cgccgccgca gcccccgcgg caaccggggc
    20701 ccatgccgcc cgccacaccg tcgacgaacc gctgctcaag ggctcggcca agctcaagcg
    20761 tcagccgggc gacaacgtcc acttcaccat cgacgcccat ggattcgccg acaaggcacg
    20821 cggcaccttc tacgtgagcc accacatcgg caagcagtgg ggcggctact tcaagggccg
    20881 tatcgactgc ctggtgaccg gtggcccggt cgccgtcgcc accggcatcg tgtccgagtc
    20941 gcatttccgg ggcgcaccgg gcatgcccac gatcggcgac ctcaagggca agcggttcgg
    21001 cttcaccgtg ctggacgacg gcaagaagga ccgactgggc tacagctggg ccatggacgg
    21061 cctgccgatg aacagtgtcg gcaagtgcct gggctcggcc cccttcgaga ccctggcgaa
    21121 gggggactac acggttcacc actggatgcc gccgcgcaag cccgccaagc actgactatg
    21181 gacgcccgta ctggacagtg acggcgtatc aggtgtggcg tgccggacct gccgcgacgg
    21241 catcggaacg gcgttcagcg cacgaagtgg atctccggga accggcgcga gggaccgtcg
    21301 agcagggggc tctgccggtg gcgcagatgc ttgtcgaaga aggccgcgag gtaggtgcgc
    21361 tggactgcga tggagcggtt gggatcgatc gtgccgagta tctgcaccag ttgctcaggg
    21421 gtcagccgga acgcgcccgc tgcctggggg aggaggacct ggttgtcgac gaaggagttg
    21481 tgcgcggagc cgagcagttt caggtcgagg cgctctccgt gcaggtggtc ccagaacttc
    21541 gcccagctcc ggtcggtgtt gcggttgtgg ttctgggaac tgaacagcag gaaggggcgc
    21601 ttgagcggct ggttggtgga cggcccgaag aattgcccgt ccaggttcgc gccggcgtcg
    21661 atcctggagt ccgcatgcat ggccgcgggc accgctcctc cgccgaggga agcgccgaac
    21721 atcccgatgc ggttcatgtt cacggccttg gagagtccgt gggggagcgg ctggtggtcc
    21781 acgtccggat tgtggccgcg ggcgagcgac gccagttgat tgatgacgaa gtgggtgtcc
    21841 gccgcccgga cggcgatcgt gtcggacgag tgggaacccg gcggcatggt gttcacctcc
    21901 acccgcccgc cggggaactc cacctcgctg gcatcgtggg tgtggtcgat ggtgaccacc
    21961 atgtagccgc gactggccag gtcctgggcg agggcggtgc ccatcgcgcg gggtgagtgg
    22021 agcccggtcg agtacagcag cacaggcagt ttgccggccc cgcggtcaac cggtgcgccg
    22081 aggtgtccgg cagtggtggg cagggtcacc gagcccggcg gcacctgcgc gcgggccaag
    22141 tagtgtgcgg cggcggctgg ttgcagccag ggcgcggcgg ggtagcggtc ggtgtccgtg
    22201 gccgggtacc acaccgagac catcagctcg cgcggctgat tgccgggcac ccacgggtcc
    22261 acgcgcgacg tgtcgcgcag gtggaggtcg accgtcccga cgcgatgacg tccggtcggc
    22321 gcggggagag tcagctgacc tggaaccggc gccgggtcca aggccgctgc cgtgtccgag
    22381 gacggcgcag tgtccaagga cgctgccgtg gccaggggcg cactggtggt cttctccgcg
    22441 gcggtggccg gggcgacccc ggcgcccaga gcgagggtca gcaaccctgt ggtgccggcg
    22501 acccgggcgc gcaaccgact ctggcgcctt cgtgcgtg
//
