LOCUS       NZ_AP026073            20930 bp    DNA     linear   CON 31-DEC-2024
DEFINITION  Streptomyces nigrescens strain HEK616 chromosome.
ACCESSION   NZ_AP026073
VERSION     NZ_AP026073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nigrescens
  ORGANISM  Streptomyces nigrescens
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Complete genome sequence of Streptomyces nigrescens HEK616
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8253039)
  AUTHORS   Asamizu,S. and Onaka,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2022) Contact:Shumpei Asamizu The University of
            Tokyo, Graduate School of Agricultural and Life Sciences; Yayoi
            1-1-1, Bunkyo, Tokyo 113-8657, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: HGAP4 v. 4.0; Falcon v. 0.3; Canu v. 0.7; Arrow
            v. 2.3.3; Pilon v. 1.22
            Genome Coverage                   :: 262x
            Sequencing Technology             :: illumina Hiseq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024349765.1-RS_2024_12_31
            Annotation Date                   :: 12/31/2024 04:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,326
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 8,032
            CDSs (with protein)               :: 8,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 84 of 204
            Pseudo Genes (incomplete)         :: 166 of 204
            Pseudo Genes (internal stop)      :: 16 of 204
            Pseudo Genes (multiple problems)  :: 56 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:47:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3335884
            Orig. end                         :: 3356814
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP026073.1.
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20930
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20930
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20930
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10930](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10930
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(175..990)
                     /locus_tag="HEK616_RS41600"
     CDS             complement(175..990)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091534.1"
                     /locus_tag="HEK616_RS41600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_315975405.1"
                     /transl_table=11
                     /translation="MHARRLATAAALALATTALVGAAPPPGTAPPPGIRTTAGQPAGST
                     EVPVERGTARFRVPAALLARLAARGVVPKALGTKGALGPHTAHDGSRTLSLRLSGGAVT
                     NSGGKAGGELRFGAAGLALVHAKAHKTVRLTRFTAELGQGTLSAGTGRGTRITLGSFPR
                     ADLRSALDTRTRVLRLKAPVTLSASAAERLNKALATKAFTRGTRLLDVRVTASLDRTAD
                     LRTALNLHGRRSPASTKARRCPPGCRRRCPSGRTGGWCGGGRSCSSSPS"
     gene            complement(1086..2435)
                     /locus_tag="HEK616_RS14570"
                     /old_locus_tag="HEK616_29590"
     CDS             complement(1086..2435)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849705.1"
                     /locus_tag="HEK616_RS14570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29590"
                     /product="MFS transporter"
                     /protein_id="WP_261953368.1"
                     /transl_table=11
                     /translation="MSSPAPSSSPARTTAGAHQPAAARSRLVRLGIPPALTWGFVGVLL
                     FMTGDGVETGFFSKYLADHGLAKADAAVVIAVYGITVAVGAWLSGALSDLWGPRRVMTA
                     GFAIWLVFQLLLLSVALPAMNFPLLLLVYGLRGFGYPLFAYGFLVWVTAATPPHRLGTA
                     VGWYWFAFTGGLPTLGSLLASVTIPQVGSYRTLWLALGLVTLGGLLALLLVREPTGWSR
                     LAPAGERPLATLAGSVSIMRRRPRVAVGAAVRVVSTGSQFGFLVCMPFFFTETAGFSTS
                     EWLRLLSVMFTANIFANLFFGAVGDRLGWQRTMTWFGAVACALTCLALYYVPLVAGPSF
                     AASAVAAALYGIALAGYVPISALVPALAPRHKGQAMSALNLGAGLSTFAGPAVVALALG
                     PFGIEGIVWIFAGLHLLTAVAIRFLEPDPEFTVSAATAAEDGAALPAGRH"
     misc_feature    2538..2547
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.85"
                     /tool="antismash"
     misc_feature    2564..2580
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.16"
                     /tool="antismash"
     gene            2613..3662
                     /locus_tag="HEK616_RS14575"
                     /old_locus_tag="HEK616_29600"
     CDS             2613..3662
                     /NRPS_PKS="Domain: PKS_ER (23-208). E-value: 8.6e-11.
                     Score: 33.4. Matches aSDomain:
                     nrpspksdomains_HEK616_RS14575_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606970.1"
                     /locus_tag="HEK616_RS14575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29600"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_261953369.1"
                     /sec_met_domain="ADH_N (E-value: 2.4e-31, bitscore: 106.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.2e-18, bitscore:
                     66.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTSAKAEIPATMRAAVLHGPERLTLEERPVPTPGPGEVLVRVE
                     AVGTCGSDVHYYRHGRIGDFVVREPLVLGHEAAGTVVACGPGVDPRRTGRRVAIEPGTP
                     CGACGECRAGRYNLCPGMRFLATPPVDGAFCEYLAVHQDFAHDVPDSLSTEDAALLEPL
                     SVAVWACRKARVAPGDRVLITGAGPIGLVAARTARAFGAREVLVTDVVPHRLELARAAG
                     ASALDVSRTPLPDAGYTPTVLLECSGVPAVTGEAIRTVGRAGRVVLIGMGGDEIPLPLS
                     RVQNHELELTGTFRYAHTWPTAIALVESGAVRLDSLVSHRYGLAEAEHALTVAAKDATA
                     VKAVIHPQR"
     aSDomain        2682..3236
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS14575_PKS_ER.1"
                     /evalue="8.60E-11"
                     /label="HEK616_RS14575_PKS_ER.1"
                     /locus_tag="HEK616_RS14575"
                     /protein_end="208"
                     /protein_start="23"
                     /score="33.4"
                     /tool="antismash"
                     /translation="RLTLEERPVPTPGPGEVLVRVEAVGTCGSDVHYYRHGRIGDFVVR
                     EPLVLGHEAAGTVVACGPGVDPRRTGRRVAIEPGTPCGACGECRAGRYNLCPGMRFLAT
                     PPVDGAFCEYLAVHQDFAHDVPDSLSTEDAALLEPLSVAVWACRKARVAPGDRVLITGA
                     GPIGLVAARTARAFGAREVLVT"
     CDS_motif       2829..2867
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEK616_RS14575_0001"
                     /evalue="3.40E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="HEK616_RS14575"
                     /protein_end="85"
                     /protein_start="72"
                     /score="10.4"
                     /tool="antismash"
                     /translation="LGHEAAGTVVACG"
     CDS_motif       3144..3194
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEK616_RS14575_0002"
                     /evalue="8.80E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="HEK616_RS14575"
                     /protein_end="194"
                     /protein_start="177"
                     /score="8.9"
                     /tool="antismash"
                     /translation="GDRVLITGAGPIGLVAA"
     CDS_motif       3399..3422
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEK616_RS14575_0003"
                     /evalue="8.20E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="HEK616_RS14575"
                     /protein_end="270"
                     /protein_start="262"
                     /score="-2.7"
                     /tool="antismash"
                     /translation="AGRVVLIG"
     gene            3705..4493
                     /locus_tag="HEK616_RS14580"
                     /old_locus_tag="HEK616_29610"
     CDS             3705..4493
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606971.1"
                     /locus_tag="HEK616_RS14580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29610"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_261953370.1"
                     /transl_table=11
                     /translation="MASTRSSLAEVDRRRQDVLAFVVERGEVRIDELARHFGVSLATMH
                     RDLDQLAERRLLRKERGRAAPFPTLTMETATRFRIGVQRPLKEALCAAVADEIRPGSTV
                     VLDDSTTSFPLAARIARTEAVAVVTNSLGVARLFDETPGAEVTLLGGRYRGEFGSCVGP
                     DVLRALGRLRADLAVMSAVSVLGGRLFHPIREYAEIKEAMLDCAQRSLLLVDHTKFGKT
                     ATHAYGDAGRYDRIVTDRATPAAELAALRDRGATVDVVDA"
     misc_feature    complement(3727..3741)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            complement(4522..5439)
                     /locus_tag="HEK616_RS14585"
                     /old_locus_tag="HEK616_29620"
     CDS             complement(4522..5439)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548149.1"
                     /locus_tag="HEK616_RS14585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29620"
                     /product="EamA family transporter"
                     /protein_id="WP_261953371.1"
                     /transl_table=11
                     /translation="MTAPPALTSPATARRPALRGTDAGVLMALASMSCVQLGLALSVRL
                     FDQLGPVGTTALRLTWAGVLLLVLVRPRRSDFTGRDLLACLGLGVVTAGLMLLFMCAVA
                     RIPLGTASALEFLGPLGVAMFGARGGRKLWASLAAVGVVLLTEPWHGGSDPVGLGLALA
                     AAACWAGYILLTQRVGDRVTGLNGLAVSMPVAALVATLFAGPSALGSVTWPLVLTGLAL
                     AVLHPVIPFSLEFLALRRLSTTAFGTLMSLEPAIALVIGAVTLGQLPGAGPAAGVVCVV
                     LAGIGATRTGRRAPASAEGPPRGE"
     misc_feature    5467..5487
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.06"
                     /tool="antismash"
     gene            5525..6472
                     /locus_tag="HEK616_RS14590"
                     /old_locus_tag="HEK616_29630"
     CDS             5525..6472
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057832.1"
                     /locus_tag="HEK616_RS14590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29630"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_261953372.1"
                     /transl_table=11
                     /translation="METRRLELLAELSRLGSMRAVAEALGTTTSTVSQQIAALARETDT
                     TLIEPDGRRVRLTPAGRRLADHAVTILAAVEAARLDLGPGAEPHGTLRVAGFGTAIRAY
                     LLPIVTELAASHPQVRVLIREHEPAEALHALAADETDLALTYDYNLAPATLDPSVGATP
                     LWTTEWGLGVPAGTQVPEGTALDVVTHFRAENWIVNSRNSADEVAIRTLASMADFTPRV
                     THQADSLDLVQAMIAAGLGVGLLPGDLAPFPGVRIVRLAAPRVVLRAYAVARHGSINWP
                     PLALVTDLLARRTGADAQRTGTDPRPPGRPPPGQ"
     gene            complement(6466..6666)
                     /locus_tag="HEK616_RS14595"
                     /old_locus_tag="HEK616_29640"
     CDS             complement(6466..6666)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEK616_RS14595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEK616_29640"
                     /product="hypothetical protein"
                     /protein_id="WP_261953373.1"
                     /transl_table=11
                     /translation="MIPRRVKDTLPELEAFAHAIQARRPAEGTWCEAWAVRDVVITDDI
                     VVTAGADGTGIRLAPPEGSGY"
     misc_feature    complement(6770..6786)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.91"
                     /tool="antismash"
     gene            6818..8035
                     /locus_tag="HEK616_RS14600"
                     /old_locus_tag="HEK616_29650"
     CDS             6818..8035
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379268.1"
                     /locus_tag="HEK616_RS14600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29650"
                     /product="AI-2E family transporter"
                     /protein_id="WP_410011195.1"
                     /transl_table=11
                     /translation="MRNRPGRKRESASGAPGSGDRRRGAGTVLRTGPARRVVIVRRTAG
                     GAPEHGPAEPAGLSPMLRAAAAYGWRLIIVGAVVYAVFVALGKFHLVTLAVFLGLVLTA
                     LLEPLTSLLNRWMPRSVAVASGLLLGIVLLFGVLSLIGANVAGEWAGLRREFDGGVARI
                     ERWLQGPPVHLSRDTLAHLQTWVRRFVSTHRSALISTALSGVDRIVEAATVGVLALFCS
                     VFFLHSGSRMWRWFGGQLPGARRRPVRLAGRAAWTTFTGYTRGIVLVAAINAVLVGVAL
                     FILGVPLAVPLAVLEFFAAFIPLVGSPVALAVAAVVALAAKGPVIALIVVLLIVVIGQI
                     EGHVLHPLVMSRAVQLHPVVVALSVVCGAVTAGVAGAIVAVPLVSVVWSVYGVLRALPA
                     ASFRTP"
     gene            8096..8371
                     /locus_tag="HEK616_RS14605"
                     /old_locus_tag="HEK616_29660"
     CDS             8096..8371
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607020.1"
                     /locus_tag="HEK616_RS14605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29660"
                     /product="hypothetical protein"
                     /protein_id="WP_030409927.1"
                     /transl_table=11
                     /translation="MSYVRLEAWIGGEWLEVDSVSVSLVESALTLSFEHQRTESGYRDL
                     IWEPLEKFLREYRDEPLVVVPRRRNLPVMFGPGAAGPFRLAEVSDG"
     gene            8656..8847
                     /gene="tgmA"
                     /locus_tag="HEK616_RS14610"
                     /old_locus_tag="HEK616_29670"
     CDS             8656..8847
                     /codon_start=1
                     /gene="tgmA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670659.1"
                     /locus_tag="HEK616_RS14610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29670"
                     /product="putative ATP-grasp-modified RiPP"
                     /protein_id="WP_261953374.1"
                     /transl_table=11
                     /translation="MRPFALSYARPAVTPSTAAPYTYDATRQLNVLPDGRPATSSRAVL
                     LATGTTASTAGSKTHFDD"
     gene            8854..9780
                     /gene="tgmB"
                     /locus_tag="HEK616_RS14615"
                     /old_locus_tag="HEK616_29680"
     CDS             8854..9780
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tgmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958810.1"
                     /locus_tag="HEK616_RS14615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29680"
                     /product="ATP-grasp ribosomal peptide maturase"
                     /protein_id="WP_261953375.1"
                     /transl_table=11
                     /translation="MTVLVLTCEEDLTADMVVTILHDRGVPLVRLDPADLPGRVALSAD
                     YAHHSFHGYLKAGERMVSLRSLRSIWVRRPGTPGTHAAEQSAWLAGEAEHALYGMLTCT
                     PARWMNHPVAAAQARYKPWQLHLAQQSGFTIPPTLITTFPSDARQFAATHRDLVVKSVS
                     GKHPGEPPMVLPTTRIGPDVDFTGVAASPTLLQRHVHKQADIRLTCVGGRLFAARKQAD
                     PDEVDSRFTQNAAWKPTEVPDTVRRSVATYLRLAQISYGAFDFAEDREGAWWFLECNQG
                     GQFGFVQLETDQPIAQAIATWLAEEPE"
     gene            10001..10930
                     /locus_tag="HEK616_RS14620"
                     /old_locus_tag="HEK616_29690"
     CDS             10001..10930
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519994.1"
                     /locus_tag="HEK616_RS14620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29690"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_261953376.1"
                     /sec_met_domain="phytoene_synt (E-value: 1e-27, bitscore:
                     95.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.5e-15,
                     bitscore: 55.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGWPVTLDRAGITDPSLRRDYTEQRRLVARFARAEYTAVRLLLP
                     PALVPDVLAATAFMHHTDDRIDQGPVAERAAALAEWDGQVRTALAGGPADEPLLRALRH
                     TVTRHPQLEPYVRAFLAGAAADLDWAGFATERDFQDYIDAYSLPAFMLLTCLLAPETGT
                     EAYVAGCRSFIEAMQRLDFLDDIAEDLPQGRLGIPQDALARHGLTHHDLTEAGPAARTA
                     FAALVPEQLALVRTGLSASCDLVERVAAPGRPLVRALLALQELRVRTVQRKGAALLAGA
                     TRPPVAGALGVLAREYRAARNRRLPVRV"
     gene            complement(10954..11520)
                     /locus_tag="HEK616_RS14625"
                     /old_locus_tag="HEK616_29700"
     CDS             complement(10954..11520)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735298.1"
                     /locus_tag="HEK616_RS14625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29700"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_261953377.1"
                     /transl_table=11
                     /translation="MGVTRTPRGKWIEEGLRALSAGGPEAVRIEALAQALGVSKGGFYG
                     YFSNREALLTEMLDAWERAVTDEVIEQVESGGGDARAKLERLFAIASSSTEGPLRGTAA
                     DLAVRDWARRDEAVARRLRRVDNRRMAYLRSLFGPLCADEDEVEVEVRSLLAFSLRIGN
                     HFIAADHGPHSRAEVMGMTAKWLLR"
     gene            11617..12201
                     /locus_tag="HEK616_RS14630"
                     /old_locus_tag="HEK616_29710"
     CDS             11617..12201
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309104.1"
                     /locus_tag="HEK616_RS14630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29710"
                     /product="DUF2867 domain-containing protein"
                     /protein_id="WP_261953378.1"
                     /transl_table=11
                     /translation="MRLPSTAHTSRPWRIHEIAGDFQVEDVWALPTPGGPDDLARLVRQ
                     FSGGAPERGAHHFSLVPRALFAARWALGHLFGWDKPVAGPGSRKWTLRDRLPADLRDGP
                     RGPDLRAVPLTSVYLTHDEWVAEIANRTVRAVMHIGWVPDGADGYRGQMAVLVKPNGPF
                     GTLYMAAIKPFRYLGVYPALFRGTGRRWQES"
     gene            complement(12229..13425)
                     /locus_tag="HEK616_RS14635"
                     /old_locus_tag="HEK616_29720"
     CDS             complement(12229..13425)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068664.1"
                     /locus_tag="HEK616_RS14635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29720"
                     /product="MFS transporter"
                     /protein_id="WP_261953379.1"
                     /transl_table=11
                     /translation="MTTSMDPRCPDSTAGVRPRLVTRALLLRFVSMVGASASFFLLLPV
                     VPRYAEASGGGSGAPGLATGTLMLATVLGELATPRLVGRFGYRVVLGGGLFLLGAPALV
                     LPLSGGMAGIVVVCFLRGLGFAAAVVAGGALTASLIPAARRGEGLALVGVVSAVPSLCG
                     LPLGVWLVAQVGYGPVAVAAGLVALVSVAAVPGLPDREVTAGPSVGVVAGLRDGALLRP
                     AAVFGTTALAAGIIVTFLPLAVASGSAGVVAVALFVQPLAAVVARWVAGRYGDRHGPSR
                     LVLPGLLLSAAGTLGLALTDSPVAVLAGVAVFGTGFGIAQNATLTLMFAHVPASGYGTV
                     SALWNVAYDAGMGVGAAGFGVLAGWTGYPAAFAVTAVLMLAALVPARRDRTAGPRHGG"
     gene            13472..14884
                     /locus_tag="HEK616_RS14640"
                     /old_locus_tag="HEK616_29730"
     CDS             13472..14884
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (122-416). E-value:
                     9.2e-21. Score: 66.3. Matches aSDomain:
                     nrpspksdomains_HEK616_RS14640_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559498.1"
                     /locus_tag="HEK616_RS14640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29730"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_261953380.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1e-18, bitscore:
                     66.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPQWSGLSPDLLVAVDRNSGEPLRSQVERQLRDAIRTGRLQVGE
                     RLPSSRQLAHEAGLSRGLVQDCYAQLQAEGYLVTRVGSATRVAAGACVPPSPAPPSHPE
                     PPRLLADFRWGVPDLRSFPLGDWLWAMREAGRTLPTAELDYGDPRGSAVLRDVLAGYLR
                     RVRAGAAAPERLVICSGYAQGLGLALRALARAGIRTVAHEDPGSPATLTAAAAAAGLSA
                     VPVPVDEQGIDVAALAATDARAVVVTPAHQWPTGVVLAPERRLAVLDWAERRDGFVIED
                     DYDAEFRYDREPVGSLQGLAADRVLAIGTVSKSLAPALRLGWLLCPPALAEPVSALKQL
                     ADRGSPTLDQLALAKLIESGRYDRQLRRMRTVYAARRDALVAALATHAPGVAVTGLAAG
                     FHAVAHLAPETDEQTVIAAARTRSVGLHGMSACRSTGATAPAQLVLGFGDLGERAITAG
                     IAAIGDLLGGPG"
     aSDomain        13838..14719
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEK616_RS14640_Aminotran_1_2.1"
                     /evalue="9.20E-21"
                     /label="HEK616_RS14640_Aminotran_1_2.1"
                     /locus_tag="HEK616_RS14640"
                     /protein_end="416"
                     /protein_start="122"
                     /score="66.3"
                     /tool="antismash"
                     /translation="PLGDWLWAMREAGRTLPTAELDYGDPRGSAVLRDVLAGYLRRVRA
                     GAAAPERLVICSGYAQGLGLALRALARAGIRTVAHEDPGSPATLTAAAAAAGLSAVPVP
                     VDEQGIDVAALAATDARAVVVTPAHQWPTGVVLAPERRLAVLDWAERRDGFVIEDDYDA
                     EFRYDREPVGSLQGLAADRVLAIGTVSKSLAPALRLGWLLCPPALAEPVSALKQLADRG
                     SPTLDQLALAKLIESGRYDRQLRRMRTVYAARRDALVAALATHAPGVAVTGLAAGFHAV
                     AHLAPETDEQTVI"
     misc_feature    complement(15068..15082)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.31"
                     /tool="antismash"
     gene            15090..15968
                     /locus_tag="HEK616_RS14645"
                     /old_locus_tag="HEK616_29740"
     CDS             15090..15968
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848032.1"
                     /locus_tag="HEK616_RS14645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29740"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_261953381.1"
                     /transl_table=11
                     /translation="MRTTEAAARERIAGALRTEADDIADRWVQLQLARAASGDGVGESA
                     LREEADALLGALLAGLEGDLPVDRVFTGHQALRQAVSDLSLRRARNGVTPTVTSLAVMA
                     LKEALMEAVQRQTRDGDELFAASVLTNRLLDTAGALSFETYVDGREEIIRRQSRQLLEV
                     STPVVRLWRQVLAVPLIGTLDTARTQVVMENLLEAIQEHEALVAIIDITGVPTVDTAVA
                     QHLMQTVNAVRLMGSDCVISGIRPPIAQTIAQLGIDLSTILTRATLADALATAIRLTDA
                     APALTGPGTER"
     gene            15965..16375
                     /locus_tag="HEK616_RS14650"
                     /old_locus_tag="HEK616_29750"
     CDS             15965..16375
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571339.1"
                     /locus_tag="HEK616_RS14650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29750"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_261953382.1"
                     /transl_table=11
                     /translation="MSSPPATGVPILRLGDVLVTGLLNELDDEAALRFTSELMERIATE
                     GARGVLIDISRLEIIDSFVARTLMELTTTARLLGARVIVAGMRPPVAITLAELGLQLTG
                     VETALNAEQGMAALGWHQSPAPPGEVRHDRRR"
     gene            16359..16838
                     /locus_tag="HEK616_RS14655"
                     /old_locus_tag="HEK616_29760"
     CDS             16359..16838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980415.1"
                     /locus_tag="HEK616_RS14655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29760"
                     /product="ATP-binding protein"
                     /protein_id="WP_261953383.1"
                     /transl_table=11
                     /translation="MTGAGESGGTTVLGDAERRAANGEAAARPVTYAVRSEQDLLTVRH
                     AVRAATRRAGFSIVDQTRVVTAASELARNAYVHGGGGALTIDYPTRRDAVGLRLTVTDD
                     GPGIDDVPTALADGYTTGNGLGHGLGGARRLMDEFDIRTEVGGGTTVTATRWAVR"
     gene            16835..17842
                     /locus_tag="HEK616_RS14660"
                     /old_locus_tag="HEK616_29770"
     CDS             16835..17842
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715852.1"
                     /locus_tag="HEK616_RS14660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29770"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_261953384.1"
                     /transl_table=11
                     /translation="MTAPPPTACVPIDHYSAVHVAAETARALARDGALPAPLPDQAAVL
                     ASELGSNLAKHAVNGALYVQRTPLGDGVEILAADRGPGMPELGRCLADGYTTTDTLGAG
                     LGAVGRIATTFTIRSAATDGTFACARLTPSARLATDLHGLGAVCLPAAGERLSGDACAV
                     ADGPDARTALVVDGLGHGPQAAEAAQLAVRTFQREPHAPLPDILHAVHRALRHTRGAAA
                     GLLRLHPDRAEYCGVGNVRALVVTPDGVHHQLTGQPGVAGLNLPRAHPRELPMEDGATA
                     VLQTDGLDHRWTRTPPPFLLRLPPPLLVAALAHGHRRTRDDATVLAANRYQRPL"
     gene            17839..19092
                     /locus_tag="HEK616_RS14665"
                     /old_locus_tag="HEK616_29780"
     CDS             17839..19092
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983506.1"
                     /locus_tag="HEK616_RS14665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29780"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_261953385.1"
                     /transl_table=11
                     /translation="MTPRVLHTLPALQQAVRGLAESSALPVETRARLVLAVSESAGAAL
                     DAGQAVTLEVTREVGRGRRGAPALVLTLRTPDATRPPRAGHSPLPARTGPDGALTWRVP
                     LSETGGGPAAHRPHGAADTATTETAALEEELRAALGRVDALVAEKRRLTEELEETNTGV
                     LALYVQLEERDERLRNAHGQTLRELEDALRPPPLTLDGLELAVHYAPAGTDAPTGGDLY
                     DWFLLPDGTVHITIVDALGHGVRSTRSALNVTHAVRTLALEGHPLESIVARAHEILTPF
                     DPDLMATVLLARLHPATGELHLANGSHPPALVVRHDGTAEFLEVRGRGVGFPLPGSERL
                     LRARLDEQDLLVLYTDGLTESRRDPLEGEQRLIESVLQHRHRPIREIPGALAEDMHAVI
                     LHSDDTLALTLRRTPQPG"
     misc_feature    18967..18969
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19126..19575)
                     /locus_tag="HEK616_RS14670"
                     /old_locus_tag="HEK616_29790"
     CDS             complement(19126..19575)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058900.1"
                     /locus_tag="HEK616_RS14670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29790"
                     /product="ATP-binding protein"
                     /protein_id="WP_261953386.1"
                     /transl_table=11
                     /translation="MSSTTARHHGTTPSAPSPSAQVTTLARRPRAAATARDITRKFLAG
                     LRPPVDDGAADAVVLVVCELVTNSVRHAAGSSCSLRLAVCGDALAVGVTDASCRPPVGR
                     APDVDGDTGGFGWPMVQRLAIATSVCLTDQGKTVHALIPCRRRAR"
     misc_feature    complement(19689..19702)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.18"
                     /tool="antismash"
     misc_feature    19795..19808
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.42"
                     /tool="antismash"
     gene            complement(19887..20471)
                     /locus_tag="HEK616_RS14675"
                     /old_locus_tag="HEK616_29800"
     CDS             complement(19887..20471)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058982.1"
                     /locus_tag="HEK616_RS14675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEK616_29800"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_261953387.1"
                     /transl_table=11
                     /translation="MQILSFPEADTPAALRAQVLDLQRQAWPPAEPSPGPHPTLTHDPA
                     LHPRSMLLVDDDGTVVAALDVLSKPLVHAGRRYRAGGLSTVVTRSAVRGRGYGRRLVAA
                     ARTAMADAGLDLGVFTCDRPLEPFYRSAGWRLLPGTHLIGGTPQCPLSSDRPPFDKVTM
                     AAFFSAEARRHHVAFRHTRLALYPGTIDRLW"
     misc_feature    20798..20810
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
ORIGIN
        1 acgcggcgct gcagcgggcg gcacagcgcc atgcggacga catggccgcc cgccggttct
       61 tcggccacac caatccggac ggtgccgatc cgggagcccg gatcaccgcg gccggctact
      121 cctggtccgc gtacggcgag aacatcgcgg tgggccggcc gacgccggcc gccgtcatga
      181 aggactggat gaacagctcc ggccaccgcc gcaccatcct ccagtgcgac ctgaaggaca
      241 tcggcgtcgg catccgggag ggcaccggcg ggccttggtg gacgcaggac ttcgccgccc
      301 gtggagattg agcgcggtgc ggaggtcggc ggtccggtcg agcgaggcgg tgacccggac
      361 gtccagcagc cgggtaccgc gggtgaacgc cttcgtcgcg agggccttgt tgagccgctc
      421 ggcggcggac gcggacaggg tgaccggggc cttgaggcgc agcacccggg tcctggtgtc
      481 cagcgcggac ctgagatcgg cgcgggggaa gctgcccagc gtgatccggg tgccgcggcc
      541 ggtgccggcg ctgagcgtgc cctggccgag ctcggcggtg aagcgggtga gccggacggt
      601 cttgtgggcc ttggcgtgca cgagggccag tccggcggcg ccgaaccgca gttcgccgcc
      661 ggccttgccg ccgctgttgg tgaccgcacc tcccgagagg cgcaggctca gcgtgcggct
      721 gccgtcgtgt gcggtgtgcg ggccgagtgc ccccttggtg ccgagggcct tggggaccac
      781 accgcgggcg gcgagccggg cgagcagggc ggccgggaca cggaagcggg cggtgccccg
      841 ttcgacggga acctcggtgc tgccggcggg ctgcccggcg gtggtccgga tgccgggcgg
      901 gggcgcggtg cccggcgggg gagcggcgcc gacgagtgcg gtggtcgcga gcgcgagagc
      961 ggcggcggtg gcgagacggc gagcgtgcat gcaggtcctc gctatgtcat gtgatgtacc
     1021 gatctgccac attacgttcc cgccgggcgg ccgcgactga acggcgccgt ccggctgacg
     1081 gccggtcagt gccggccggc cggaagggcc gcaccgtcct cggccgcggt ggcggcggac
     1141 acggtgaact ccgggtccgg ctccaggaac cggatcgcga ccgcggtcag gaggtgcagt
     1201 ccggcgaaga tccagacgat cccttcgatc ccgaacggtc ccagggcgag cgcgacgacg
     1261 gccggcccgg cgaaggtgct gagccccgcg ccgaggttga gcgcggacat cgcctgcccc
     1321 ttgtggcgcg gcgccagcgc cggcacgagc gccgagatcg gtacgtagcc ggccagcgcg
     1381 atgccgtaga gggcggcggc caccgcggac gcggcgaacg acgggccggc caccagcggg
     1441 acgtagtaca gcgcgaggca ggtcagtgcg caggccacgg caccgaacca ggtcatggtg
     1501 cgctgccagc cgagccggtc cccgacggcg ccgaagaaga gattggcgaa gatgttcgcg
     1561 gtgaacatca cgctgagcag ccgcagccac tccgaggtgc tgaatccggc cgtctccgtg
     1621 aagaagaacg gcatgcagac caggaacccg aactgggaac cggtgctgac gacgcgtacc
     1681 gcggcgccga cggcgacccg cggacggcgc cgcatgatcg agacgctgcc cgccagcgtc
     1741 gccagcggcc gttcaccggc cggcgcgagc cgggaccatc cggtgggctc gcgcaccagc
     1801 agcagggcga gcagtccgcc gagcgtcacc agtccgagcg cgagccagag tgtgcggtac
     1861 gagccgacct gcgggatcgt cacgctggcg agcagcgaac cgagggtcgg caggccgccg
     1921 gtgaaggcga accagtacca gccgaccgcc gtgcccagcc ggtgcggcgg ggtcgccgcg
     1981 gtcacccaca ccaggaaccc gtaggcgaac aaggggtagc cgaagccgcg cagcccgtag
     2041 acgagcagca ggagcggaaa gttcatcgcc ggcagcgcga ccgacagcag gagcagctgg
     2101 aagacgagcc agatggcgaa cccggcggtc atcacgcgcc gcggccccca gaggtcggac
     2161 agcgctccgg agagccaggc gccgacggcg acggtgatgc cgtagacggc gatgacgacc
     2221 gccgcatcgg ccttggccag gccgtggtcg gccaggtact tcgagaagaa cccggtctcc
     2281 acgccgtcgc cggtcatgaa gagcagcacg ccgacgaaac cccaggtgag agccgggggt
     2341 atgcccagtc gtacgaggcg ggagcgggcg gctgccggct ggtgcgcacc ggccgtggtc
     2401 cgggccgggc tcgacgacgg ggcggggctg ctcatgggcc ctccagggcg gagaaggaag
     2461 gggacgcggg ttccaccgcc gcgtcggcgg agccggaaga tgccgccgaa cggtggaccg
     2521 gccgcaaagt cttctcgtat tttgtgcgaa gtcaagcctg ctctgctaaa aaagagcgca
     2581 catcctcgaa gacccaggga gccgtgcccg ccatgaccac cacctccgcc aaggccgaga
     2641 tccccgccac catgcgcgcc gccgtcctgc acggccccga gcggctgacg ctcgaagaac
     2701 gccccgtccc cacccccggg cctggggagg tcctggtccg cgtcgaagcg gtcggcacct
     2761 gcggctccga cgtgcactac taccggcacg gccggatcgg cgacttcgtc gtacgggaac
     2821 ccctcgtcct cggccacgag gcggccggca ccgtggtcgc ctgcggaccg ggcgtggacc
     2881 ctcggcggac cggccggcgc gtcgccatcg agcccggcac cccgtgcggc gcctgcggtg
     2941 aatgccgggc gggccgctac aacctctgcc ccggcatgcg cttcctcgcc acacccccgg
     3001 tcgacggcgc cttctgtgaa tacctggccg tccaccagga cttcgcccac gacgtccccg
     3061 actccctgtc caccgaggac gccgccctgc tggagccgct ctcggtcgcc gtctgggcct
     3121 gccgcaaggc ccgcgtcgcc ccgggggacc gggtactgat caccggcgcg ggaccgatcg
     3181 gcctggtcgc cgcccgcacc gcacgcgcct tcggcgcccg ggaggtgctc gtcaccgacg
     3241 tcgtcccgca ccgcctggaa ctcgcccgcg cggccggcgc cagcgccctc gacgtctccc
     3301 gcaccccgct gcccgacgcc gggtacaccc ccaccgtgct gctggagtgc tcgggcgtcc
     3361 ccgcggtgac cggcgaggcg atccgcaccg tcggccgggc cggccgggtc gtgctcatcg
     3421 gcatgggcgg ggacgagatc ccgctcccgc tcagccgggt gcagaaccac gaactcgaac
     3481 tcaccggcac cttccgctac gcccacacct ggcccaccgc gatcgcgctg gtggagtcgg
     3541 gtgcggtccg gctcgactcg ctggtctcgc accgttacgg tcttgccgag gccgagcacg
     3601 cactgaccgt cgccgccaag gacgcgaccg cggtgaaggc cgtcatccat ccgcagcggt
     3661 aggcgcgccg ctgccgctgt gcgaccggga aaggggcggc cccgatggct tccacacggt
     3721 cgtcgctggc cgaggtcgac cggcgacgac aggacgtact ggccttcgtc gtcgagcgcg
     3781 gagaggtccg gatcgacgaa ctggcccggc acttcggggt cagcctcgcg accatgcacc
     3841 gcgacctgga ccagctcgcc gaacgccggc tgctgcgcaa ggaacgcggc cgggccgcac
     3901 ccttcccgac cctcaccatg gaaaccgcca cccgcttccg catcggcgta cagcgcccgc
     3961 tgaaggaggc gctgtgcgcc gcggtcgccg acgagatccg gcccggcagc accgtcgtcc
     4021 tggacgactc gaccacgtcg ttcccgctcg ccgcgcggat cgcccggacc gaggcggtcg
     4081 ccgtggtcac caactccctc ggcgtggccc ggctgttcga cgagacgccc ggcgccgagg
     4141 tcaccctgct cggcggccgc taccgcggcg agttcggctc ctgcgtcggc cccgacgtcc
     4201 tgcgcgccct cggccggctg cgcgccgacc tcgcggtgat gtcggcggtc tccgtcctcg
     4261 gcggccggct cttccacccg atccgcgagt acgccgagat caaggaggcc atgctggact
     4321 gcgcccagcg ctccctgctc ctcgtcgacc acaccaagtt cggcaagacc gccacccacg
     4381 cgtacggcga cgccgggcgc tacgaccgca tcgtcaccga ccgcgccacc cccgccgccg
     4441 aactcgccgc cctgcgcgac cgcggcgcga cggtcgacgt ggtggacgcc tgacctgttc
     4501 ttgcgcgcag cggcacggcc gtcactcgcc gcgaggcggg ccctccgcgg acgccggtgc
     4561 gcggcggccg gtgcgggtgg cgccgatgcc ggcgaggacc acgcagacga ccccggcggc
     4621 cgggcccgcg ccgggcagct ggccgagggt gacggcgccg atgacgaggg cgatggccgg
     4681 ttccaggctc atcagggtgc cgaaggcggt ggtggagagc cggcgcaggg ccaggaattc
     4741 gaggctgaac gggatgaccg ggtgcagcac cgccagcgcc agaccggtga gcaccagcgg
     4801 ccaggtcacc gaccccaggg cggacggtcc ggcgaacagc gtggcgacca gggcggccac
     4861 cggcatcgag acggccaggc cgttcagacc ggtgacccgg tcaccgacgc gctgggtcag
     4921 caggatgtac ccggcccagc aggccgcggc ggccagcgcg agcccgaggc cgaccgggtc
     4981 gctcccgccg tgccagggct cggtgagcag caccaccccc accgcggcca gcgaggccca
     5041 cagcttgcgg ccgcccctcg ccccgaacat ggccacgccg agcggcccca ggaactccag
     5101 tgcgctggcc gtccccagcg gaatgcgggc gaccgcgcac atgaagagca gcatcagccc
     5161 ggccgtcacc acccccagtc cgaggcaggc gagcaggtcc cggccggtga agtcggagcg
     5221 gcgcgggcgg acgaggacca gcaggagcac ccccgcccac gtcaggcgca gcgccgtcgt
     5281 tcccaccggc ccgagctggt cgaagagccg caccgagagc gcgagtccca gctggacgca
     5341 gctcatcgag gcgagggcca tcaggacacc ggcatccgtc ccgcggaggg cggggcgacg
     5401 ggcggtggcg ggggacgtca gggcgggtgg cgcggtcatg gccgccagta gacggtctcg
     5461 gcatcgttgc cgtccacgtg ccgatcatgg acattccgtt cgggaaagct gaacaatggc
     5521 gcgcatggag accaggcgcc tggaactgct ggccgaattg tcccggctgg ggtcgatgcg
     5581 tgccgtcgcc gaggccctcg ggacgaccac ctcgacggtc tcgcagcaga tcgccgcgct
     5641 cgcccgtgag acggacacca cgctcatcga gccggatggg cgccgggtcc ggctgacccc
     5701 ggcgggccgg cggctggccg accacgccgt gacgatcctc gccgcggtcg aggcggcccg
     5761 gctcgacctg gggcccgggg ccgagccgca cggcaccctc agggtcgccg gattcggcac
     5821 ggcgatccgt gcgtacctgc tgccgatcgt caccgagctc gcggcgagcc acccccaggt
     5881 gcgggtcctc atccgcgagc acgagcccgc cgaggccctg cacgccctcg ccgccgacga
     5941 aacggacctc gcgctcacct acgactacaa cctcgcaccg gccaccctcg acccgtccgt
     6001 cggcgcgacg ccgctgtgga ccacggaatg gggcctgggc gtccccgccg gtacgcaggt
     6061 ccccgagggc acggccctgg acgtcgtcac ccacttccgc gcggagaact ggatcgtcaa
     6121 ctcccggaat tccgcggacg aggtggccat ccgcacgctc gcctcgatgg cggacttcac
     6181 gccccgggtg acccatcagg ccgacagcct cgacctggtg caggcgatga tcgccgcggg
     6241 gctgggcgtc gggctgctgc ccggggacct cgcgcctttc cccggcgtcc gcatcgtccg
     6301 gctggcggca ccgcgggtcg tcctgcgcgc gtacgccgtg gcccgccacg gcagcatcaa
     6361 ctggcccccg ctggcgctgg tgaccgacct cctcgcccgc cggaccggtg cggacgccca
     6421 acggaccggt acggaccccc gcccgccggg ccgcccgccg ccgggtcagt agccgctgcc
     6481 ctccggtggg gcgaggcgga tgccggtgcc gtccgcgccg gccgtgacca cgatgtcgtc
     6541 cgtgatcacc acgtcgcgga cggcccacgc ctcgcaccag gtgccctcgg cgggccgccg
     6601 cgcctgtatg gcgtgggcga aggcctccag ctccggaagc gtgtccttga ctcgcctcgg
     6661 gatcatgacc gctcgataac cggtcatatc cggacacgaa cgtcctcgtg cgctcgggtg
     6721 ccttcggggg aatgccggtc cgcgggcgtt cgagaaccgc tgtggggtga taccacctct
     6781 gggtaggcac gggcgcgcgg agggcggtgg cggccaggtg cggaaccgac ccggcaggaa
     6841 gcgggagagc gcgtccggcg ccccggggag cggcgaccgg cggcgcggtg cgggcaccgt
     6901 actgcggacc ggccccgccc ggcgggtcgt gatcgtacgc cggacggcgg gcggggcgcc
     6961 ggagcacggc ccggccgaac ccgccgggct gtccccgatg ctccgggccg ccgccgcgta
     7021 cggatggcgc ctgatcatcg tgggtgcggt cgtctacgcg gtcttcgtgg cgctgggcaa
     7081 gttccacctg gtgaccctgg cggtcttcct ggggctcgtc ctgacggccc ttctggagcc
     7141 gctgaccagc ctgctgaacc gctggatgcc ccggtcggtg gcggtcgcgt ccggtctgct
     7201 gctcggcatc gtgctgctct tcggcgtgct gagcctgatc ggcgcgaacg tcgcggggga
     7261 gtgggcgggc ctgcgccggg agttcgacgg cggtgtggcc aggatcgagc gatggctcca
     7321 gggcccgccg gtccacctga gccgcgacac cctcgcacat ctgcagacct gggtccggcg
     7381 gttcgtctcc acccaccgtt cggcgctgat cagtacggcg ctgagcggcg tggaccggat
     7441 cgtcgaggcc gcgacggtgg gcgtgctcgc actgttctgc tcggtcttct tcctgcactc
     7501 cggcagccgg atgtggcgct ggttcggcgg ccagctgccc ggcgcccggc gccgccccgt
     7561 tcgcctcgcg gggcgcgccg cctggacgac gttcaccgga tacacccgcg ggatcgtcct
     7621 ggtcgccgcg atcaacgccg tgctcgtggg cgtcgcgctg ttcatcctgg gggtgccgct
     7681 cgccgtcccg ctggccgtgc tggagttctt cgccgccttc atcccgctgg tcggctcgcc
     7741 ggtcgcgctg gccgtggccg ccgtggtggc gctggccgcc aagggcccgg tgatcgcgct
     7801 gatcgtcgtg ctgctgatcg tggtcatcgg tcagatcgag ggccatgtgc tgcatccgct
     7861 cgtgatgagc cgcgcggtcc agctgcatcc ggtcgtggtg gcgctctcgg tggtctgcgg
     7921 cgcggtcacc gccggcgtgg ccggcgcgat cgtcgcggta ccgctcgttt cggtggtgtg
     7981 gtccgtctac ggcgtactgc gcgcgctccc cgccgcgtcc ttccgtaccc cctgagcgcg
     8041 gcgcgcgccc ggacgccgat tgcggccgcc gcaccgtccg gggcactctt gcgtcatgtc
     8101 atacgtgcgg ctcgaagcct ggatcggtgg ggagtggctg gaggtggact cggtgagcgt
     8161 gagcctcgtg gagtccgccc tcacgctctc cttcgagcac cagcggaccg aatccggcta
     8221 ccgggacctc atctgggaac cgctggagaa attcctccgc gagtaccgcg acgaaccgct
     8281 cgtcgtcgta ccgcggcgac gcaatctgcc ggtgatgttc ggccccggcg ccgcggggcc
     8341 gttccggctc gccgaggtgt cggacggctg accatcgctg acaccccgtc agaggaggcg
     8401 tatttcacgg ccatctacgg cacggcagag ggaatgctct cctaggggcc ccggcgccgt
     8461 gccgtcagac cgaacgtacc gggtcggcag ctacgttctc accgcatttc cgtcaagagg
     8521 atcgtcggaa acgagcaaaa ctggcaacta tttgaccgga ctgtcgcgtc ctccgtgcag
     8581 agtcatcagg tgggggctcc cgtcaccaca ccgccaccgc ggcgggtggg aaccgggtct
     8641 tgtaaaggag aaagcatgcg accgtttgcg ttgagctacg cccggccggc ggtgacgccg
     8701 tcgaccgccg ctccgtacac ctatgacgcc acgcggcaac tcaacgtact gcccgacgga
     8761 cgcccggcca cctccagccg ggccgtgctg ctggccaccg gcaccaccgc gtccacggcc
     8821 ggctccaaga cccacttcga cgactgagcg tccatgaccg tcctggtcct cacctgcgag
     8881 gaggacttga ccgcggacat ggtggtcacg atcctccacg accgcggtgt cccgctcgtc
     8941 cgcctcgacc cggccgacct gccgggccgg gtcgccctgt cggcggacta cgcccaccac
     9001 tccttccacg gttacctgaa ggcgggcgag cgcatggtga gcctgcgcag tctgcggtcg
     9061 atatgggtcc gccggcccgg gacccccggc acccacgccg cggaacagtc cgcctggctc
     9121 gccggggagg ccgagcacgc cctctacggc atgctcacct gcacaccggc gcgctggatg
     9181 aaccaccccg tcgcggccgc gcaggcccgc tacaagccct ggcagctgca cctcgcccag
     9241 cagagcggtt tcaccatccc gcccaccctg atcaccacct tcccgtccga cgcccggcag
     9301 ttcgccgcca cccaccgcga cctcgtggtg aagtcggtct ccggcaaaca ccccggcgaa
     9361 cccccgatgg tgctgcccac cacgcgcatc ggcccggacg tggacttcac cggagtggcc
     9421 gcctccccca cgctgctcca gcgccacgtc cacaagcagg ccgacatccg gctcacctgc
     9481 gtcggcggcc ggctcttcgc cgcccgcaag caggccgatc cggacgaggt cgacagccgc
     9541 ttcacccaga acgccgcctg gaagcccacc gaggtccccg acacggtccg gcgctcggtc
     9601 gccacgtacc tgcgcctcgc ccagatctcc tacggcgcgt tcgacttcgc ggaggaccgg
     9661 gagggggcct ggtggttcct ggaatgcaac cagggcggcc agttcggctt cgtccagctc
     9721 gagaccgacc agcccatcgc ccaggccatc gccacctggc tggcggagga accggagtga
     9781 caccggtacc ttccacaccg ggctccgcgg cctcgaaccg ggtcccggaa cgacgggctc
     9841 agcgcggcgg cagcgccccg gcatacggcg attgtcgccc gtacggggcg ctgagggggg
     9901 tggggcggta cggcgagtgt gccggggcgg cgtgccaccc ggtgcgaaat ctcccgcgca
     9961 ggtcgtctag ggtcgtcgcg gcaccaatga ggggagcggt atggccggct ggccggtgac
    10021 actcgaccgg gcggggatca cggacccgtc gctgcggcgc gactacaccg aacagcgccg
    10081 cctggtcgcg cggttcgccc gcgccgaata caccgcggtg cggctgctgc tcccccctgc
    10141 gctggtcccc gatgtcctcg ccgccacggc cttcatgcac cacacggacg accggatcga
    10201 ccaggggccc gtggcggagc gtgccgcggc cctcgccgaa tgggacggac aggtacgaac
    10261 ggcgctcgcg ggcggcccgg cggacgagcc gttgttgcgc gcgctgcggc acaccgtcac
    10321 ccggcacccc caactggagc cgtacgtaag ggcgttcctg gccggggcgg ccgcggacct
    10381 ggactgggca gggttcgcca ccgagcggga cttccaggac tacatcgacg cctattcgtt
    10441 gcccgccttc atgctcctca cctgcctgct cgcgcccgag accggtacgg aggcgtacgt
    10501 ggcgggctgc cgcagcttca tcgaggcgat gcagcgcctc gacttcctgg acgacatcgc
    10561 cgaggacctg ccgcaggggc ggctcggcat cccccaggac gccctggccc ggcacgggct
    10621 cacccaccac gacctgaccg aggccggtcc cgccgcccgt accgccttcg cggccctggt
    10681 gccggagcaa ctggcgctgg tccggaccgg gttgtcggcc tcgtgcgacc tggtcgagcg
    10741 ggtggcggca cccggccggc cgctcgtccg cgcgctgctc gccctgcagg aactgcgggt
    10801 gcgcacggtg caacggaagg gcgcggccct gctcgccggc gccacccggc cgccggtcgc
    10861 cggtgcgctc ggggtcctgg cccgggaata ccgggcggcg cgcaaccggc ggcttcccgt
    10921 gcgggtctga gagagcatcg tccaaagggg cggctaccgc agcagccatt tcgcggtcat
    10981 ccccatcacc tccgcgcggc tgtgcgggcc gtggtcggcg gcgatgaagt ggttgccgat
    11041 ccgcagcgag aaggcgagca ggctgcgtac ctcgacctcg acctcgtcct cgtcggcgca
    11101 gagcgggccg aacagcgaac gcaggtacgc catgcgccgg ttgtcgacgc gccgcagccg
    11161 ccgggcgacg gcctcgtcgc gccgggccca gtcgcggacc gcgaggtcgg ccgcggtgcc
    11221 ccgcagtggc ccctccgtgg acgacgaggc gatcgcgaac agccgctcca gcttggccct
    11281 ggcgtccccg cctccgctct cgacctgctc gatcacctca tcggtgaccg cgcgctccca
    11341 ggcgtcgagc atttcggtga gcagggcctc ccgattgctg aagtacccgt agaagccgcc
    11401 cttgctgacg ccgagggcct gtgccaaggc ctcgatccgg acggcttcgg ggccgcccgc
    11461 ggagagcgcg cgcagtcctt cctcgatcca cttgccgcgc ggcgtgcggg tcacgcccat
    11521 gctgcgtctc ctctcacttc tcgcccggtc tatacggagc cgtatagacc ggtgctagcc
    11581 tagatctata cgccaccgta tagatagggg ccggccatga gactccccag caccgcgcac
    11641 acctcccgtc cctggcgcat ccatgagatc gccggggact tccaggtcga ggacgtgtgg
    11701 gcgctcccca cgcccggcgg tccggacgat ctcgcgcgcc tggtgcgcca gttcagcggc
    11761 ggtgcacccg aacgcggggc ccaccacttc tccctcgtac cgcgggccct cttcgccgcg
    11821 cggtgggcgc tcggacacct cttcgggtgg gacaagccgg tcgccggtcc cggcagccgg
    11881 aagtggacgc tgcgggaccg gctgccggcc gacctccgcg acggcccgcg gggacccgac
    11941 ctccgcgcgg tgccgttgac ctccgtctac ctgacgcacg acgagtgggt ggccgagatc
    12001 gccaaccgga ccgtgcgggc ggtgatgcac atcggctggg tcccggacgg agccgacggc
    12061 taccgcgggc agatggccgt cctcgtcaag cccaacgggc cgttcggcac cctctacatg
    12121 gcggccatca agcccttccg ctacctgggc gtctacccgg cgctgttccg cgggaccggc
    12181 cgcaggtggc aggagagctg acgcaccgga cctcgcgcgg acgcaccgtc aaccgccgtg
    12241 gcgcggcccg gcggtgcggt cgcgccgggc cgggacgagc gctgccagca tcaggacggc
    12301 ggtgaccgcg aaggccgccg gatagcccgt ccacccggcg agcaccccga agccggccgc
    12361 gcccacgccc atgcccgcgt cgtacgcgac gttccacagc gcgctcaccg tgccgtaacc
    12421 ggaagcgggc acgtgggcga acatcagcgt cagggtggcg ttctgcgcga tgccgaatcc
    12481 ggtgccgaag acggcgacac cggcgagcac ggcgaccggg ctgtccgtca gcgcgaggcc
    12541 gagcgttccg gcggcggaca gcagcagacc gggcagcacc agccgggagg gcccgtgccg
    12601 gtcgccgtac ctgccggcga cccagcgcgc gacgaccgcg gcgagcggct ggacgaacag
    12661 cgccactgcg accacgccgg ccgagccgga cgccacggcg agcggcagga acgtcacgat
    12721 gatcccggcc gcgagcgcgg tggttccgaa gaccgccgcg ggccgcagca gcgccccgtc
    12781 gcgcagcccg gcgaccacac ccaccgacgg ccccgccgtc acctcccggt cgggcagtcc
    12841 gggcaccgcg gcgaccgaca ccagcgcgac cagcccggcg gccaccgcga ccgggccgta
    12901 ccccacctgc gccaccagcc acacgcccaa cggcaggccg cacagcgacg gcaccgccga
    12961 gacgacgccg accagcgcca gcccctcccc gcggcgcgcg gccggtatga gcgaggcggt
    13021 cagcgcgcca cccgcgacga cggccgccgc gaaccccagc ccgcgcagga aacagacgac
    13081 gacgatcccc gccattccgc ccgagagggg cagtaccagc gcgggtgccc ccaggaggaa
    13141 caggccaccg cccagtacca cccggtagcc gaagcggccc accaggcggg gagtggccaa
    13201 ctcccccagg accgtggcca gcatcagcgt tccggtggcc aggcccggcg ccccgctgcc
    13261 cccgccggac gcctcggcgt accgcggcac gaccggcaac agcaggaaga agctcgcgga
    13321 ggcaccgacc atgctcacga agcgcagcag cagcgcgcgg gtcaccagcc gcggccgcac
    13381 accggccgtg ctgtccgggc aacgggggtc catcgatgtg gtcatggggc gacgctaaag
    13441 tccgggtgga cccccggtaa gctccaattc cgtgccgcca cagtggtccg gtctgtcgcc
    13501 cgatctcctg gtagccgtcg accggaacag cggcgaaccg ctgcgctccc aggtggaacg
    13561 ccaactgcgg gacgccatcc gcaccggccg gctccaggtc ggcgaacggc tgccctcctc
    13621 ccgccaactc gcccacgagg ccgggctgtc ccgcggcctg gtgcaggact gctacgccca
    13681 gctccaggcc gagggctacc tcgtgacccg ggtcggctcc gccaccaggg tcgccgccgg
    13741 cgcctgcgta ccaccgtcgc cggccccgcc gtcccacccc gaacccccgc gcctgctggc
    13801 cgacttccgc tggggcgtcc ccgacctccg gtcctttccg ctcggcgact ggctgtgggc
    13861 gatgcgcgag gcggggcgca ccctgcccac cgcggaactc gactacggcg acccgcgcgg
    13921 cagcgccgtg ctccgcgacg tcctcgcggg ctatctgcgc cgggtacggg ccggcgcggc
    13981 cgcccccgaa cggctcgtga tctgctccgg ctacgcccag ggcctcggcc tggccctgcg
    14041 cgccctggca cgggccggca tccgcaccgt cgcccacgag gaccccggct caccggccac
    14101 cctcaccgcg gccgcggccg cggccggcct gtcggcggtg cccgtaccgg tggacgagca
    14161 gggcatcgac gtcgcggcgc tggccgccac cgacgcccgg gccgtcgtgg tcacgcccgc
    14221 ccaccagtgg ccgaccggag tggtcctcgc ccccgagcgg cggctggccg tgctcgactg
    14281 ggcggagcgc cgggacggct tcgtcatcga ggacgactac gacgcggaat tccgctacga
    14341 ccgggagccg gtcgggtcgt tgcagggact cgcggccgac cgggtcctgg ccatcggcac
    14401 cgtcagcaag tccctcgccc cggcgctgcg cctcggctgg ctcctctgcc cgccggccct
    14461 ggccgaaccc gtcagcgcgc tcaagcaact ggccgaccgc ggttccccga cgctcgacca
    14521 gctggccctg gcgaagctga tcgagtccgg caggtacgac cggcagttgc gccggatgcg
    14581 gacggtctac gcggcccgcc gggacgccct ggtggcggcg ctggccaccc atgcccccgg
    14641 cgtcgcggtg accggcctgg cagcgggctt ccacgccgtc gcccacctcg cacccgagac
    14701 cgacgagcag accgtgatcg ccgccgcccg tacccggtcc gtcggcctgc acggcatgag
    14761 cgcctgccgc tcgacgggcg ccaccgcacc cgcccaactg gtcctcggtt tcggcgatct
    14821 cggtgagcgc gcgatcacgg ccggtatcgc cgcgatcggg gacctgctgg gcggcccggg
    14881 ctgagggcgg ccaagccagg acgaattcct gcccgcgcac cggtcggccc gcactcttcc
    14941 tgatcggacc gcctcgaact gggcatcctg atacgtgacc gcctcggtag cattgccggc
    15001 ggcgaggaag atcgcgagcg gccgggggcg gctcgcgcgg aacgaccggg gcggcaccgc
    15061 cctggtaaat cgtcagaaag gattggggtt tgcgtaccac cgaggcggca gcacgggagc
    15121 gcatcgcggg ggcgttgcgc acggaggccg acgacatcgc cgaccgctgg gtgcagttgc
    15181 agctggcccg ggcggcctcg ggggacgggg tcggcgagag cgcactgcgc gaggaggccg
    15241 acgcactgct cggcgccctg ctcgccggtc tggagggcga cctcccggtg gaccgggtct
    15301 tcaccggcca ccaggcgctg cggcaggcgg tgtccgacct ctcgctgcgc cgggcccgca
    15361 acggcgtgac ccccaccgtg acctcgctcg cggtgatggc gctgaaggaa gcgctgatgg
    15421 aggccgtaca gcggcagacc cgggacggcg acgagctctt cgccgcctcc gtcctcacga
    15481 accgtctgct ggacaccgcc ggcgcactgt ccttcgagac ctacgtcgac ggccgggaag
    15541 agatcatccg caggcagagc cggcagctgc tcgaagtctc cacgcccgtg gtgcggttgt
    15601 ggcgccaggt gctcgccgtc cccctgatcg gcaccctgga caccgcccgc acccaggtcg
    15661 tgatggagaa cctcctggag gccatccagg agcacgaggc gctggtcgcc atcatcgaca
    15721 tcaccggcgt gcccacggtc gacacggccg tggcccagca cctgatgcag accgtcaacg
    15781 cggtacggct gatgggctcg gactgcgtga tcagcgggat ccggccgccg atcgcccaga
    15841 ccatcgccca gctcggcatc gacctgtcca ccatcctcac ccgcgccacc ctcgccgacg
    15901 cactggccac cgcgatccgg ctcaccgacg ccgcgccagc cctgaccgga ccggggacgg
    15961 agcgatgagc agcccgcccg ccaccggagt gccgatcctg cgcctcgggg acgtcctggt
    16021 caccgggctc ctcaacgagc tcgacgacga ggccgccctg cgcttcacca gcgagctcat
    16081 ggagcggatc gccaccgagg gagcccgcgg ggtgctgatc gacatctccc ggctggagat
    16141 catcgactcc ttcgtcgccc gcacgctgat ggaactcacc accaccgccc gcctgttggg
    16201 cgcccgggtc atcgtggccg gcatgcgccc gccggtggcc atcacgctcg ccgagttggg
    16261 actgcagctg accggggtgg aaaccgccct caacgcggaa cagggcatgg cggccctggg
    16321 ctggcaccag agcccggcgc cacccggaga ggtacgccat gaccggcgcc ggtgagtccg
    16381 ggggcacgac cgtgctcggg gacgcggaac gccgcgcggc caacggcgag gccgccgccc
    16441 ggccggtcac gtacgccgtg cgcagcgaac aggacctgct gacggtccgt catgccgtgc
    16501 gggccgccac ccgccgcgcc ggcttcagca tcgtcgacca gaccagggtc gtcaccgccg
    16561 ccagcgaact cgcccgcaac gcctacgtcc acggcggcgg gggagccctc accatcgact
    16621 acccgacccg gcgggacgcg gtcggtctgc ggctgaccgt caccgacgac ggccccggca
    16681 tcgacgacgt ccccaccgcg ctcgccgacg gctacaccac cggcaacggc ctcggacacg
    16741 gcctgggcgg cgcccggcgg ttgatggacg aattcgacat ccgcaccgag gtgggcggcg
    16801 ggacgaccgt gacggccaca cggtgggccg tacgatgacc gccccgccgc ccacggcgtg
    16861 cgtccccatc gaccactaca gcgccgtcca cgtcgccgcg gagaccgccc gcgcgctggc
    16921 ccgggacggc gcgctgcccg caccgctgcc cgaccaggcc gccgtcctcg cctccgaact
    16981 gggcagcaac ctcgccaaac acgcggtcaa cggcgccctg tacgtccagc ggaccccgct
    17041 cggcgacggc gtggagatcc tcgccgccga ccgcgggccg ggcatgccgg agctcgggcg
    17101 gtgcctggcc gacggctaca ccaccaccga caccctcggc gcgggcctgg gcgcggtcgg
    17161 ccggatcgcc accaccttca cgatccgcag cgccgcgacc gacgggacct tcgcctgcgc
    17221 ccggctcacc ccgtccgccc gcctcgccac cgacctgcac ggcctcgggg cggtctgcct
    17281 cccggccgcc ggcgaacggc tcagcggtga cgcctgcgcc gtcgccgacg ggccggacgc
    17341 ccgcaccgcc ctcgtcgtcg acggactggg ccacggcccg caggccgccg aggccgcaca
    17401 gctcgcggta cgcacctttc agcgcgagcc gcacgccccg ctgcccgaca tcctgcatgc
    17461 cgtccaccgc gccctgcgcc acacccgcgg cgccgccgcc ggactgctgc ggctgcaccc
    17521 ggaccgcgcc gagtactgcg gcgtcggcaa cgtccgcgcc ctggtggtca cccctgacgg
    17581 cgtccaccac cagctcaccg ggcagcccgg cgtggccggc ctgaacctgc cccgcgccca
    17641 cccccgggag ctgcccatgg aggacggggc caccgccgtg ctgcagaccg acggcctgga
    17701 ccaccgctgg acccgcaccc cgccgccgtt cctgctgcgc ctgccgccgc ccctgctcgt
    17761 ggccgccctg gcccacggcc accgccgtac cagggacgac gcgaccgtcc ttgccgccaa
    17821 ccgctatcag agacccttgt gaccccacgc gtactccaca ccctcccggc gctccagcag
    17881 gccgtccgcg ggctggccga atccagtgcg ctgcccgtcg agacccgggc gcgtctggtg
    17941 ctcgccgtga gcgaatcggc cggtgccgcg ctcgatgccg gccaggcggt gaccctggag
    18001 gtcacccgcg aggtcggccg gggccggcgc ggcgcgcccg cgctcgtcct caccctccgc
    18061 accccggacg ccacccgccc cccgcgcgcc gggcactccc cgctgccggc ccgcaccggc
    18121 cccgacgggg cactgacctg gcgcgtcccg ctctccgaga ccggcggcgg gccggcagcg
    18181 caccgcccgc acggcgccgc ggacaccgcg acgaccgaga ccgccgcgct ggaggaggaa
    18241 ctgcgggcgg ccctgggccg ggtggacgcc ctcgtggccg aaaagcgccg gctgaccgag
    18301 gaactggagg agaccaacac cggggtgctg gccctctacg tccagctcga agagcgcgac
    18361 gagcggctcc gcaacgccca cggccagacg ctgcgcgaac tcgaggacgc cctgcggcca
    18421 ccgccgctca ccctcgacgg cctggagctc gccgtccact acgcaccggc cggcaccgac
    18481 gcccccaccg gcggagacct ctacgactgg ttcctgctcc cggacggcac cgtgcacatc
    18541 accatcgtcg acgccctcgg ccacggcgtg cgcagcaccc gcagcgcgct caacgtcacc
    18601 cacgcggttc gcaccctggc cctcgaaggc caccccctgg aatcgatcgt ggcgcgcgcc
    18661 cacgagatcc tcaccccctt cgaccccgat ctgatggcca cggtcctgct cgcccggctc
    18721 caccccgcca ccggcgaact gcacctggcc aacggcagcc acccgccggc gctggtggtc
    18781 cgccacgacg ggaccgcgga attcctggag gtacgcggcc gcggcgtggg cttcccgctg
    18841 cccggtagcg aacggctgct gcgcgcccgg ctggacgagc aggacctgct ggtgctctac
    18901 accgacggcc tcaccgagag ccgccgggac ccgctggagg gcgaacagcg gctgatcgag
    18961 agcgtgttac agcaccggca ccgcccgata agggagatcc ccggtgccct ggcggaggac
    19021 atgcacgcgg tcattctgca ctccgacgac accctcgcgc tgaccctccg ccggaccccg
    19081 cagccggggt aggcaagagc accgcgggtg ttcacgggtg ggcactcacc gggcccgccg
    19141 gcggcacggg atcagtgcgt gcaccgtctt gccctggtcc gtcaggcaca ccgacgtggc
    19201 gatcgcgagc cgctggacca tcggccagcc gaaccccccg gtgtcgccgt cgacatcggg
    19261 cgcccgtccc acgggcggac ggcaggacgc gtcggtcacg cccaccgcga gcgcgtcgcc
    19321 gcagacggcc agccgcagcg aacacgagga accggccgcg tgccgtacgg agttggtgac
    19381 gagctcgcag accacgagca ccaccgcgtc ggcggcgccg tcgtccaccg ggggccgcag
    19441 gcccgccagg aacttccggg tgatgtcgcg cgccgtggcg gccgccctgg gccgcctggc
    19501 cagcgtcgtc acctgtgccg acggcgaggg ggccgacggc gtcgtgccgt ggtgccgggc
    19561 cgtggtgctg ctcaacagga tcacctcgtt cgtgtcgtcc tcgagacgtg ccaccgggcc
    19621 gccacatcgt cctcccgcgc acgtctccgg tccgccggcc gtcgtccgcc ggccattccg
    19681 tgtgccctac acggagagtc actcctctcg tgtgtccatc gcagcgcaag tcaagagcat
    19741 ggccctgacc tgctgttccg tcagcctctt cggttgcgga tcgttcctac cctggtcacc
    19801 ctgcgttaat ccgcccgccg gtgaaggatc gtcggatccc acgaccgcgg gaggcaactg
    19861 ctgcccggac cacgcccgcc gacgcctcac cagagccggt cgatcgtccc cggatacagc
    19921 gcgagacggg tatgccggaa cgcgacgtgg tgccgccggg cctcggcgga gaagaaggcg
    19981 gccatggtga ccttgtcgaa gggaggccgg tcgctggaga gggggcactg cggagtgccg
    20041 ccgatgaggt gggtgccggg cagtagccgc cagcccgcgc tccggtagaa cggttcgagg
    20101 ggccggtcgc aggtgaacac gcccagatcc aggcccgcat cggccatggc cgtacgggcg
    20161 gcggccacca gccgccggcc gtatcccctg ccgcgtacgg cggaccgggt cacgaccgtg
    20221 ctcagtccgc ccgcccggta gcgccggccc gcgtgcacca acggcttgga cagtacgtcc
    20281 agcgccgcca ccacggtgcc gtcgtcgtcg acgagcagca tcgagcgggg atgcagcgcc
    20341 ggatcgtggg tgagggtggg gtgtgggccg ggggagggct cggccggggg ccaggcctgg
    20401 cgctggaggt ccaggacctg cgcgcgcagt gctgcgggag tgtccgcttc cgggaaggac
    20461 aggatctgca tgcggtgatc gtgcctgtcc gcactccgca ccgaaagcgc gttttcgccc
    20521 gcgggcggct caggtcccca gacagtcgac gaacgacacc cgcccgcccg cgccctcgat
    20581 gaagtcctgc gcggagtggt tgcgcagcag gcacatgtcg tagcgggcct tcgggccgcc
    20641 gccggcgtcc tcctcgtaga agtgcttccc ggacagctgg cacgagtcgt aacgcaccaa
    20701 cgggccccgg gggccgatgc ggtagcggtg cgggcggctc gtctccgcga acggcttgaa
    20761 ggagtgggcg gtgtcgtcgc agtcgttgaa gtgcaccgtg ccgctgtccc aggcgcagtc
    20821 gatcacgacg gtgtccgggc cgcgcacctc gaagcggatg tcctcggcgt ggaagcgctg
    20881 gacggagtcg tggtgcgggc cgcgcgggaa acggaagaag gtgctggtcc
//
