LOCUS       NZ_JANAVN010000006     26307 bp    DNA     linear   CON 26-JUL-2024
DEFINITION  Paenibacillus sp. Lou8.1 NODE_6_length_349503_cov_144.562623, whole
            genome shotgun sequence.
ACCESSION   NZ_JANAVN010000006
VERSION     NZ_JANAVN010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus sp. Lou8.1
  ORGANISM  Paenibacillus sp. Lou8.1
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 349503)
  AUTHORS   Gonzalez-Pimentel,J.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2022) Agroquimica, Microbiologia Ambiental y
            Conservacion de Suelos, Instituto de Recursos Naturales y
            Agrobiologia, Av. Reina Mercedes 10, Sevilla 41012, Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.14.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024213565.1-RS_2024_07_26
            Annotation Date                   :: 07/26/2024 02:53:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,316
            CDSs (total)                      :: 5,255
            Genes (coding)                    :: 5,159
            CDSs (with protein)               :: 5,159
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 4, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 40 of 96
            Pseudo Genes (incomplete)         :: 74 of 96
            Pseudo Genes (internal stop)      :: 9 of 96
            Pseudo Genes (multiple problems)  :: 25 of 96
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 186915
            Orig. end                         :: 213222
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JANAVN010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26307
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26307
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26307
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16307](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16307)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(214..231)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            1004..1486
                     /locus_tag="NLX78_RS10650"
                     /old_locus_tag="NLX78_10650"
     CDS             1004..1486
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002194742.1"
                     /locus_tag="NLX78_RS10650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10650"
                     /product="DUF1641 domain-containing protein"
                     /protein_id="WP_061829711.1"
                     /transl_table=11
                     /translation="MAKPISIVRKRILTEEERQKQSLDQLTADLADNGAALQKTLEIVR
                     ELHDSGLLEAAQSMLKAKESIAKIAVGQATRKPVTNIINNLMGAAGMLSEVDPELMKKL
                     ANSVTNGLNEADKHLKQNKKTRLRDLMKAMNDPDVNRAMGFGIHFLKGVGKSLSDK"
     gene            complement(1569..1922)
                     /locus_tag="NLX78_RS10655"
                     /old_locus_tag="NLX78_10655"
     CDS             complement(1569..1922)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372255.1"
                     /locus_tag="NLX78_RS10655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10655"
                     /product="hypothetical protein"
                     /protein_id="WP_254350444.1"
                     /transl_table=11
                     /translation="MGLENKVRRYYQLKQKQKEIEGELTDLRNDITAHCAQQEVSDWEI
                     GNFRVKIIQQHRKEYDHTKLYDSLPDPQLWRLFSKPDTSKIASLLKLKVIAEEQIKDAV
                     SLKTVTLLQVDKK"
     gene            complement(2063..3064)
                     /gene="kdgT"
                     /locus_tag="NLX78_RS10660"
                     /old_locus_tag="NLX78_10660"
     CDS             complement(2063..3064)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015649 - 2-keto-3-deoxygluconate:proton
                     symporter activity [Evidence IEA]"
                     /GO_process="GO:0046411 - 2-keto-3-deoxygluconate
                     transmembrane transport [Evidence IEA]"
                     /codon_start=1
                     /gene="kdgT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821679.1"
                     /locus_tag="NLX78_RS10660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10660"
                     /product="2-keto-3-deoxygluconate transporter"
                     /protein_id="WP_254350445.1"
                     /transl_table=11
                     /translation="MKIKQNIDKIPGGIMLVPLFIGALFHTFTPWAGDYFGSFTKGLMT
                     GTVPILAVWFFCMGASIDVRATGTVLRKSGTLVLTKIAVAWVVAIIASRLLPVGGIESG
                     LFAGLSVLALISAMDMTNGGLYASIMQQYGSKEEAGAFVLMSLESGPLVTMIILGSTGL
                     AVFEPQTFVGAVLPFLVGFMLGNLDHDFRKYFGNATQALIPFFGFALGCSIDLSVIVQT
                     GMLGILLGIFVIIVTGIPLILADKYIGGGNGTAGIAASSTAGAAVANPVIVANIKPEFL
                     PVAQSATALVAASVIVTSILVPILTAYWANYMKRKGKSQGAGPVKPGVNVPK"
     gene            complement(3113..4120)
                     /locus_tag="NLX78_RS10665"
                     /old_locus_tag="NLX78_10665"
     CDS             complement(3113..4120)
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431353.1"
                     /locus_tag="NLX78_RS10665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10665"
                     /product="tripartite tricarboxylate transporter substrate
                     binding protein"
                     /protein_id="WP_069290055.1"
                     /transl_table=11
                     /translation="MKKKPWQKYVLVAAGVAMLSALSISEYVDHRTLQDHSRIFPTKPI
                     TLVVPYAAGGGTDITARALAKAAEKHLGQPIIVVNRTGGGGSVGLMEGAEAQADGYTVT
                     YLVAELTTLPHLGLLPLTYERFKPLLQTNMDPSAITVRADAPWKTAEAFLEDAGAHPGK
                     LKMGNAGTGSIWHLAAAMLEQKSGVRFTHIPYEGAGPAVSALMSGFVDAVPVSPAEVKK
                     YVDEGKLRILAIQADTISEAFPKVPTLQQSTGLRVHFIGTWRGLAVPKDTPDEVAQTLT
                     DALIKGTKDEEFREEMRKHGLGLRVQDAEAFARQLKESHDTFARLIPELGLSRK"
     gene            complement(4250..6691)
                     /locus_tag="NLX78_RS10670"
                     /old_locus_tag="NLX78_10670"
     CDS             complement(4250..6691)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428228.1"
                     /locus_tag="NLX78_RS10670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10670"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_254350341.1"
                     /transl_table=11
                     /translation="MDNQVRKDEVTGMLRLKLRLILKNKQTRLILLLTLCVSLVISMIG
                     LLSYSRYREGLDTELNTPNIELLQINLDVTNRAFRESDNKALDAAYHPDVEAFVRVQTD
                     GESLEDKASVIDRLHKYLKTLSSHEEIYSVEVISLDNHALVSSNYGYRPDWKQAPDTTW
                     VPWIQDIEKKPLLIKRRWYGTDHEQGAVELLSLARPIVENGQVMGAVLINLDYDRFFSK
                     LYIHLSNSQYVYDLEGELIYPKLRSSLPLNDMGRILKELDVSPYAYVEIGDMEYMANQT
                     FSDVTGWRLVSLVPMDKLLKNVKLARNMMLWLAFVSILAGCSAVYYYNYAAFRPMKKIN
                     SLLNSGNKGTRQGGLYDLEPVIRKLVGEFHRKSLVVERSLPELRSKYMEDVIQRRMGIQ
                     EMRMKWEQYFSDWDGHSLFVMIVSIDRYSAWAASFPEEDKMLLKYALNNILLEMLEPHW
                     KAVCSPEEESGFIVLLQFSESSNEVGTETDLQESILLQKSVDRLIQVVGEYLPLTISIG
                     IGHMVTDIREVRASFIKGKEALNLRLYEGYGRSYTNIDSSISVKKDNTVDKQSKEQIQD
                     STLLDNRRVEMIRALESQEPGASVKLISHWVEELRLHRTSPAQVYLFVHELLEDLLKWC
                     ATQSVTPPDQLADYHWNQILTLDLQDMEVLLVIMLTDIEEKWNGRIQSKDFVRVQEMIE
                     YMEHHLHLNIGLQEIADHVHMSVSSVSSMFKEETGTTVYDYLTGLRVKKACTLLCETHL
                     KIGEIAEQVGYRNENSFIRVFRKHKQVTPGKFRQISKSSNEYADRSKGRYFGEIEDKYE
                     D"
     gene            complement(6906..8561)
                     /locus_tag="NLX78_RS10675"
                     /old_locus_tag="NLX78_10675"
     CDS             complement(6906..8561)
                     /GO_component="GO:0098561 - methyl accepting chemotaxis
                     protein complex [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1061: methyl-accepting
                     chemotaxis protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010345244.1"
                     /locus_tag="NLX78_RS10675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10675"
                     /product="methyl-accepting chemotaxis protein"
                     /protein_id="WP_254350342.1"
                     /transl_table=11
                     /translation="MKLQGKLVLNAMISLIACLALVAYIIFELIRINSQSSNLVPAMLN
                     VQQLNAYLIQSGQALQNYSASMTESNKADVQNQLTQSEKTIALLSQGMMQTEAQQKRLN
                     TIKTKFSQLKVATEKAMSTQNSPESKREAMRAQGIQNDVFMLDLLTKARYDQYTEDLTK
                     SIRFTWQLALAGAVILLVAVGLYNTYTSRQLALRTRKLTDAAKQIAEGNLTVQLAQTKG
                     RDELDELNESFRVMIGNLRSIVLSIDQAGNRVDLMARDIDQHNEAMKEIVTQVSTSTEE
                     LAIGSQKIAEDLSSTVGVVDEMQQKFESNLLETTQSTAYSEDALRVIEQGTRVMSDQLR
                     IVAENRSAMSEVEQTVKELEANAAEITTMTGYVSEIASQTSLLSLNASIEAARAGEAGK
                     GFAVVANEVKKLANQSESAVKKIYTAVDSITQAMDKVKTSVAQSQELFREQEKVTSSTG
                     ESFTEISGKVQQIASQVSKLSTDMNVSRELSVQVQQAIENISAITQQSAAGSEEITAST
                     VEQKRSFEESAEKVKELRQIREEMQRELDRFQVE"
     gene            complement(8589..9593)
                     /locus_tag="NLX78_RS10680"
                     /old_locus_tag="NLX78_10680"
     CDS             complement(8589..9593)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013311249.1"
                     /locus_tag="NLX78_RS10680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10680"
                     /product="BMP family protein"
                     /protein_id="WP_061829702.1"
                     /transl_table=11
                     /translation="MKKRAVLLNFRWIPIVTIFALLLSACGQSAAQTKAQPIKVGIVLS
                     DIGLGDQSYSDAAFRGLVKARDEGKIVFEYREITETKTYDAAFEQLAQEKADLIIGLGY
                     MVKDSLESIAKKYPDRKFLIVDEKSDLPNVASISFKAEEGSFMAGVVAGLTSRTEQVGF
                     LGGAESPLLKKFEIGYRAGVQSVKPNAKVTATYAGDFGKPELGTEIADDMINQDQIDVI
                     FAAAGLTGVGALQEAQKQHKFAIGVDSDQFFIAEKAVVTSMFKNVDIAIYTAVKGFADH
                     QRKFTEKDMVFGLAEDGVGLAPIRVVTLSPDQQKLLDDLKEKIKSGTLTVPTQ"
     gene            complement(10001..11383)
                     /locus_tag="NLX78_RS10685"
                     /old_locus_tag="NLX78_10685"
     CDS             complement(10001..11383)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="NLX78_RS10685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10685"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_254350343.1"
                     /sec_met_domain="LANC_like (E-value: 3.4e-64, bitscore:
                     211.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAQLPFSSWRPLSGEIRERVVKVLDSIGERYKNPEEVCLRSKS
                     MPILEVDGFEIERWNDGTLSNGYPGICLLLAQLDLLYPENGWDRIGHMYLEKLQKQMEE
                     MGMYDLSLYSGLAGVLIGIRALSRDGTRYQSMLNQVASWFEELAAERIPLYMKQWHSGY
                     LKMSDYDTILGFTGIGRIVLLFYERPKMKELWEQIVVWFQLFCGDKNWEGQCIPAWHIR
                     AENQFLQDEKRQYPKGNFNLSLSHGIAGPLALMSISVLQGITTEQVKKEIATLAEWLAK
                     WQFESQVGTIWPGKVSFEEWEQSELSVENTEYQRDSWCYGAPGIARSIWLAGQALQNDE
                     WISLGLKAYLDIENRIERNGGMVSATVCHGIGGLLHLLQRMYSDTGNERLGALRDLLVE
                     RVLDLFEPSSLFGYYDINFLNGDYRNIDEAGFLTGTAGVALVLASLISDRSPEWDAVLM
                     IR"
     gene            complement(11380..13257)
                     /locus_tag="NLX78_RS10690"
                     /old_locus_tag="NLX78_10690"
     CDS             complement(11380..13257)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="NLX78_RS10690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10690"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_254350344.1"
                     /transl_table=11
                     /translation="MKDMVNKNNGLHSAWKSVKSGLKLLRLISSANKRYLVLSIMFYFI
                     QGITPIFTLAVMQNVLNKVSVALQQGAGLVIVPFGWFVLVYVVKNIVNAAQGYVEGTLE
                     AVLSKSLNIMICEKSTRLGLADYENATINDQLKRASQEASYRPYQLYTQMAGIVSSLIT
                     MISSAIWLILWKWWIVLILLIVSVVSLYSLFKINREQFQIYMERTPQYRQSWYMTYLLT
                     NDRAVKEVKIFQLGPYLLERYSNLLESFFKVDRRMLGRLTRFTLMYNLLELGVMLWFVW
                     LAMKETLLTNIMIGSLYGYIQAIMLTQSQIQMMMRGILQFSQNNLYIEQLFLFLKLPTS
                     DPVYHQKKLNYMQPSGAGHDFRIEQISFEGVSFKYPGQSRYALHNVRLSLSKGETVAIV
                     GKNGSGKTTLMKILMQLYADYSGTISVNGCNIKDYELADIQRKIGAVFQDFMQYEMSAR
                     HNIGFGDLEQLEDDRTLMDAARYVAMDDVIQKLSHGLNTQLGKWFEEGHQLSGGQWQRL
                     AIARAFVRKADVYILDEPSSFLDPVAERDLLELFLDLMKERIGIFITHRISSARLAHHI
                     VVMEDGQIIEQGTHEYLVRLGGVYSEMYQVQASSFAAGTVTNKGGVFQS"
     gene            complement(13254..16307)
                     /locus_tag="NLX78_RS10695"
                     /old_locus_tag="NLX78_10695"
     CDS             complement(13254..16307)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="NLX78_RS10695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10695"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_254350446.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.3e-176,
                     bitscore: 580.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.7e-12,
                     bitscore: 40.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.8e-38, bitscore:
                     127.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIELSNDPAIKEAIAVSSPSLHESLFRLQDVDDPRKQEQVLKGFM
                     RYLLRMMTRPTPFGLFSGVSVGHFGESSQLYLKNTHAHRKRARPDMEWTLKIIEKIESI
                     PEVLCQLRLQSNPLIYRQGNRAKIPYTTRYGKLVNGENDSVSVKASAVFDYIMEVCAQP
                     VLFSTLVKLVMQRFSEAGEERVDPYIRQLFEQEFLISELRPSTIKSDPFVQILAIINPL
                     YGMEDLKLQLQSIHQDIRLYNELPIGEGEERLKLLRQVMSEVSDIEMSTLQVDLSVEDH
                     SIVLNEYIRKDVERVAELFSQLTSQTDAHLKEYTDEFLEKYGYGREVPLLELLDEEMGL
                     GAPATYRHPQSRRRSLKTGKIAKTQANREQLLFQWFVSSIHKGNYEMNLTDEMIGQLTH
                     TEDSITRPTLPSMELYFLLNTRDQQALDRGEYTLLLGPNPGSNGAGKTFGRFMDLLGTP
                     FKKEFQAIHLEEQSLYPEKIWAEVSYLPSSGRTTNVILVENFRDYEIAIGTNQALPDDR
                     QIQVSDLVVGLRGDHFYLKSRKHNREVIPTTGHMLNYHQAPNVYRFLIEVGLAGFGQWN
                     TVNWGIMTQAPFTPRLRYNNIIFAPATWRMWFRQDKDKPLGTEALKKAVTQFCLEWKVP
                     RHVYLIQSDHRILLDLEHPLHIEELCKELKSGNSIVLIELTGGFEQLPIYCSEGRLTAE
                     FVFPLVRRPVTSSGTLQEVAAASEDVGSATSMQTVSLAQRVHFPGGVWFYAKLYGMESR
                     QNEFIGLYWDECIRQAKETGIVEYGYYIRYADPESHIRVRFKMSSEKFVPDFFTMFHDW
                     AKVWIREGLMTKFVIDTYEPEIERYGGPELMGLAESMFADDSEIAARLIRLNRFKQNKL
                     DLDIVAVLSVIHLLRQLGFNEAESYDVLNQKYNVKEFLSEFRKERRLYLQFLDKTFTQE
                     EGQSQNQINDILDLFKIRESTAFCYQQKILEQEKQSSLMNTKDDILFSIIHMHLNRLLG
                     IDRYRERKIMIMARHAMNSLVHYHRKVK"
     aSDomain        complement(15693..15962)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NLX78_RS10695_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.70E-13"
                     /identifier="RREFam001.1"
                     /label="NLX78_RS10695"
                     /locus_tag="NLX78_RS10695"
                     /protein_end="205"
                     /protein_start="115"
                     /score="40.2"
                     /tool="antismash"
                     /translation="NPLIYRQGNRAKIPYTTRYGKLVNGENDSVSVKASAVFDYIMEVC
                     AQPVLFSTLVKLVMQRFSEAGEERVDPYIRQLFEQEFLISELRPS"
     gene            complement(16612..16788)
                     /locus_tag="NLX78_RS10700"
                     /old_locus_tag="NLX78_10700"
     CDS             complement(16612..16788)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="NLX78_RS10700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10700"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_254350345.1"
                     /transl_table=11
                     /translation="MANDAFDLDVQVNKSKGSVEPQVLTSIAACSAVACGGQRTENCGK
                     TYGNCVSNIGDWC"
     CDS_motif       complement(16723..16788)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MANDAFDLDVQVNKSKGSVEPQ"
                     /locus_tag="NLX78_RS10700_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16612..16722)
                     /prepeptide="core"
                     /locus_tag="NLX78_RS10700_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="9.60"
                     /molecular_weight="3545.0"
                     /monoisotopic_mass="3542.6"
                     /core_sequence="VLTSIAACSAVACGGQRTENCGKTYGNCVSNIGDWC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MANDAFDLDVQVNKSKGSVEPQ"
                     /leader_location="[16722:16788](-)"
                     /alternative_weights="3563.0"
     misc_feature    16826..16841
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(17196..17211)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.21"
                     /tool="antismash"
     gene            complement(17312..17902)
                     /locus_tag="NLX78_RS10705"
                     /old_locus_tag="NLX78_10705"
     CDS             complement(17312..17902)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431357.1"
                     /locus_tag="NLX78_RS10705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10705"
                     /product="restriction endonuclease"
                     /protein_id="WP_254350346.1"
                     /transl_table=11
                     /translation="MLLEKLLAYKELGIGLIVLLVLFALIIRGLIRGRRNRILRDLDPR
                     KIGIQDIDRMEDGSEFELYLQRLLSALGYKDIYKTTSSRDFGADLVFTDREGVRVVIQA
                     KRYGVQHPVGLGAVQEIYTSMRYYAADKSVVITSGRYTESCKTLAAVNGVKLLDRNDLM
                     DMIDLFKAKRREEVMERIESKTDVVASKWSKTK"
     gene            complement(18078..19487)
                     /gene="aspA"
                     /locus_tag="NLX78_RS10710"
                     /old_locus_tag="NLX78_10710"
     CDS             complement(18078..19487)
                     /EC_number="4.3.1.1"
                     /GO_function="GO:0008797 - aspartate ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aspA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821686.1"
                     /locus_tag="NLX78_RS10710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10710"
                     /product="aspartate ammonia-lyase"
                     /protein_id="WP_254350347.1"
                     /transl_table=11
                     /translation="MRLEHDFLGTKEVPSDAYYGVQTLRAKENFPITGQRLHPELIKAM
                     AIVKKGAATVNMELTRLHRPKAEAIIQAADEIIQGQLHDHFIVDPIQGGAGTSINMNTN
                     EVIANRALELIGKQRGDYQEISPNNHVNMAQSTNDAFPTAVHLAVLSMIDKLLATMSEL
                     QEAFSRKANEFDSVIKMGRTHLQDAVPIRLGQEFQAYARVLGRDIGRVRATKQHLLTIN
                     MGATAVGTGLNADRRYIQRVAEVLADVSGFPVEADENLVDATQNTDAYTEVSAALKICM
                     MNMSKVANDIRLMASGPRAGLGELSLPARQPGSSIMPGKVNPVMCEVINQIAFQVIGND
                     HTICLASEAGQLELNVMEPVLVYNLLQSLEIMKQGFHVFRIHCVEGIEANVERCREYVE
                     NSVGIITALNPHLGYEVVSRIAREAITTGKSVRELCLLYNVLTEEELDIILDPYQMTQP
                     GIAGESLLNRE"
     gene            complement(19688..20218)
                     /locus_tag="NLX78_RS10715"
                     /old_locus_tag="NLX78_10715"
     CDS             complement(19688..20218)
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821687.1"
                     /locus_tag="NLX78_RS10715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10715"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_069290057.1"
                     /transl_table=11
                     /translation="MSNEMRVYPVQALDEALVDSLSRLLIDVVADGASIGFLPPLGYQE
                     AATYWNNVLEDGVVLWIAEKDGVPVGTVQLHLAQKANAIHRAEIAKLMVHPSGRRLGIA
                     RQLMKAAEEEALSQDRTLLVLDTRVGDPSNGLYEAIGFVEAGVIPGYAQSADGQLHATR
                     YYYKSLNPYSSHS"
     gene            complement(20328..20729)
                     /locus_tag="NLX78_RS10720"
                     /old_locus_tag="NLX78_10720"
     CDS             complement(20328..20729)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372266.1"
                     /locus_tag="NLX78_RS10720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10720"
                     /product="VOC family protein"
                     /protein_id="WP_061829696.1"
                     /transl_table=11
                     /translation="MGVKAKQIFVNLPVKNLQQSIDFFTTIGFEFSAQFTDEHATCMVV
                     SEHIFVMLLVEERFKAFTTKEISDATKSTEAIVALSVESREKVDEIVHKALEAGGKPSN
                     EPQDHGFMYGWSFQDLDGHLWEFFYMAEQ"
     gene            complement(20845..24225)
                     /locus_tag="NLX78_RS10725"
                     /old_locus_tag="NLX78_10725"
     CDS             complement(20845..24225)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015338.4"
                     /locus_tag="NLX78_RS10725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10725"
                     /product="S-layer homology domain-containing protein"
                     /protein_id="WP_254350447.1"
                     /transl_table=11
                     /translation="MKQEYIEKILPTKLKRFGITWLSAILLLSAGGPAGLSSGKASAEP
                     ASFAGKEVQPSPVTVGASVYADVYFPKKLRIHDVQGAAHRSPYEGQKVADIEGVVTMVK
                     GSSFYIQELDAQVDQDEKTSEAILVYKPSHGAQVGDEVRVSGSVKEYTERTYASKPIDL
                     TTTEIVASSVKVIANDRPLPAPILLGEQGRVMPTSVVDHDGMTVFDPQEDGLDFFESLE
                     GMRVELKDATVIGPYGYEIPVRIVNGPNTGEVVTEAGGLMLTERSLNPQRILIDAKPST
                     PLKTGDRFAGSITGVVSYSFSNYKLLPERMPDVVPGGLQPANTRLIGDDRKLTVASFNV
                     ENFDPGDGKRIDQLGQTIAVNLNHPDIIGLLEVQDNNGEKDDGTTDASESFRVLIEAIR
                     AHGGPEYNFTDIGPENNKDGGAPGGNIRVGFLYNPQRVTLTDKPKGDSVTSVTYGVQGL
                     SLNPGRIDPLNASFEDSRKPLAAEFEFEGQQVIVVANHFNSKGGDQAPFGGIQPPVRSS
                     EIQRAKIAAIVNGFVKSVLQVNPKANMVVLGDLNDFQFSETLALLRGQELTNLIDHLDE
                     KERYSYIYEGNSQTLDHMLVSPSLSKTSVLDIVHMNADFSAADGRVSDHDPLVAQIDLP
                     RKAEEPPTDSGSGRNDDDEEDQQDNEGNANAGNGSSGNANGTVNGQGQTASGEPNGSSL
                     SGTNVVQVRSVVTGVEQNGLKKAVAQVTTAEIQKAIQNGVKGTLVIRAGEQVEAGTYEV
                     HLNGEALGAVLNDRIRTLRVETPQGGYEVTTSRLSLQKLADTWQVPVKQISLNFSIASN
                     EELAKRLDVPTGRTLLQALDIAAELRSEDGRKQLLVGNGDSGRGYERYLLRVPAMVDTD
                     QLAVVKVSSTNQVGQLSYQPVPFHTSSEEITVYGRSGGTYAVLDGGSSGEVRSFMDISG
                     HWAQQDITRLATRLLVTGTHSTASTATATRERDLANVHFEPEGQVRRSELVAMLVRVLG
                     LERTDRTLTSFDDVQPESWYADSVRTAAAAGLINGYTDGSFRPDTPVSREELAVIIERA
                     LRFAGNTEENTREVSESISVSLSDAQEISTWAAPAVKTLSGLGILRGDEKGRFGPATSV
                     TRAEAAAVLSRTLDKLHWE"
     gene            24409..25572
                     /locus_tag="NLX78_RS10730"
                     /old_locus_tag="NLX78_10730"
     CDS             24409..25572
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (30-372). E-value: 1e-67.
                     Score: 220.8. Matches aSDomain:
                     nrpspksdomains_NLX78_RS10730_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431362.1"
                     /locus_tag="NLX78_RS10730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NLX78_10730"
                     /product="aminotransferase A"
                     /protein_id="WP_254350348.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.2e-67, bitscore:
                     220.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.7e-13,
                     bitscore: 44.2, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHLLNDQVKNIQISGIRKIANKVAALPGTLSLTIGQPDFPTPAH
                     IMEAAHRAINEGRTSYTPNPGLPELREAAAAFVARKYGLNYLGQDEVIVTNGASEALDI
                     TLRTILSPGDEVILPVPIYPGYEPLIRLSGGIPVFADTRNSGFKLTAEVLEPYLTEQTK
                     AVILGYPSNPTGRVMSREELEAVADLLKERDLFIISDEIYSELIYETPHVSIAALPGMR
                     ERTIVINGLSKSHSMTGWRIGFTLAPAEITQHMVKVHQYNVTCASSISQYAALEALTVG
                     VDDALPMREEYRKRRDYVHGRLTDMGIPLEKPEGAFYLFPSIAHFGLSSMDFTLKLLEE
                     HGVAVVPGDAFSSYGEGYIRLSYAYGQDVLEQGLDKIERFVRGIVRS"
     aSDomain        24499..25524
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NLX78_RS10730_Aminotran_1_2.1"
                     /evalue="1.00E-67"
                     /label="NLX78_RS10730_Aminotran_1_2.1"
                     /locus_tag="NLX78_RS10730"
                     /protein_end="372"
                     /protein_start="30"
                     /score="220.8"
                     /tool="antismash"
                     /translation="LSLTIGQPDFPTPAHIMEAAHRAINEGRTSYTPNPGLPELREAAA
                     AFVARKYGLNYLGQDEVIVTNGASEALDITLRTILSPGDEVILPVPIYPGYEPLIRLSG
                     GIPVFADTRNSGFKLTAEVLEPYLTEQTKAVILGYPSNPTGRVMSREELEAVADLLKER
                     DLFIISDEIYSELIYETPHVSIAALPGMRERTIVINGLSKSHSMTGWRIGFTLAPAEIT
                     QHMVKVHQYNVTCASSISQYAALEALTVGVDDALPMREEYRKRRDYVHGRLTDMGIPLE
                     KPEGAFYLFPSIAHFGLSSMDFTLKLLEEHGVAVVPGDAFSSYGEGYIRLSYAYGQDVL
                     EQ"
ORIGIN
        1 gatgtatatc gctggagaag agatggcatg ggtggatgcc gactccaacc atacccaaga
       61 aatgctggcg aacttggatt tccttgtcgt tcaggatgta tttctgagca aaacagctga
      121 attcgctgac gttattttgc cagccgtacc ttcactcgaa aaagacggaa cctttacgaa
      181 caccgaacgt cgtgtccagc gtttatatga agctctcctc cctatgggag acagtaagcc
      241 ggattggtgg attttcagcc aatttgccaa gtacatggga tttgattggg attacagcca
      301 tccaagtgaa atttttgagg aaatggcgtc gctcactcca tttttctccc aatgtaatta
      361 tgacgtattg gaaggctgga acagcttcca ctggggatcg ccggatggta gcaatacacc
      421 gctactgcac accaacggct ttaactttcc ggataaaaaa gcgcgtttgg gacttttcga
      481 atatgtgcca ccgaaagagt accctgttga attcgatctg accttaaata atggtcgact
      541 gctcgaacag tttcatgaag gaaatatgac gaccaaatcg gcaggcattc agctgaaact
      601 tccaaaagta tttgtagaag tgtcccctga attggctgaa gaacgcggaa tccataatgg
      661 atcgctggtt cgattggaat ccccttatgg tgcggtcaag ctacgcgttc tggttacaga
      721 ccgggtgcag ggaactgaaa tttatgtgcc gatgcactct accagccatg atggtgcggt
      781 caatctgtta actggtggag cgttcgatgt ggtcacccgt acaccggcct ataaacaagc
      841 caaagtacgg atgcaaattt tggaggtaga cggtcaaaat ccactaccac gtatcaatcc
      901 gcgttacaaa aagcgtcatc cgcaaaatgg ggttgaagtg gaccgtaagt ggaatcgtcc
      961 tggttacgtc gatttagtgg atcaaaaata aggaggtcaa gccgtggcta agcctatttc
     1021 aattgtgaga aaacgcattt tgacagaaga agaacggcaa aaacaatcgc tggatcagct
     1081 tactgctgat ctggcggaca atggggcggc attgcagaag acacttgaaa tcgtacgtga
     1141 actgcacgat agtggtcttc tcgaagcagc tcagtctatg ctaaaggcta aagaaagcat
     1201 cgccaaaatc gctgtaggac aagcaacgcg taagcctgtg acgaacatca tcaataatct
     1261 catgggagca gcagggatgc tgtctgaggt agaccccgag ctgatgaaaa agctggcaaa
     1321 cagtgttact aatggcctga acgaagccga taaacatcta aagcagaata aaaagactcg
     1381 tctgcgcgat cttatgaagg cgatgaatga tccagatgta aaccgggcaa tgggatttgg
     1441 cattcatttt ctcaaaggag tgggaaaaag tttgtctgat aaatagctca tagagcgtga
     1501 agatggaaga ctagtaacaa cagacaataa aaagagctgg ctccgaaaac ggggacagct
     1561 ctttttattt attttttatc cacctgtaat agcgtcaccg ttttaagaga aacggcatct
     1621 tttatttgct cctctgcgat gaccttgagc ttaagcaaac tggcaatctt cgacgtatcc
     1681 ggcttggaaa acaagcgcca tagctgcgga tcaggcagtg aatcatacag ctttgtatga
     1741 tcatattcct tgcggtgctg ctgtataatc ttgactcgga agttgccaat ttcccaatct
     1801 gatacttcct gctgtgcaca atgtgcggta atgtcattac gcaaatcagt cagttcacct
     1861 tcaatttctt tttgcttttg ctttaactgg tagtagcgac gcaccttgtt ttccaatccc
     1921 atcacgctcc tctgcttaca tatgtatgtt tgcagaagcg ttttaggaca agttttgtga
     1981 tgttaggatt aaaggtacaa ctgcaaaagc atttcccggg taatggaaag ttccatgagt
     2041 ttgagccatc atcatccaaa ctttatttag gcacattcac ccctggtttt acaggtcctg
     2101 ctccttggga ttttccctta cgtttcatat aattggccca gtatgccgtc agaataggta
     2161 ctaaaatcga ggtcacaatg accgaagcag caactaaggc cgttgcagat tgcgctacag
     2221 gcagaaactc aggcttgatg ttggcgacaa tgactggatt ggctactgct gcacctgctg
     2281 tactggaggc tgcaatccct gctgtaccgt tgccaccacc gatatattta tcagccaaaa
     2341 tcagcggaat acctgtaacg ataatgacaa aaatgcccaa taaaatacca agcatgcctg
     2401 tctggacaat gacactcagg tcaatggaac aaccaagtgc aaaaccgaaa aatggaatca
     2461 aagcttgcgt tgcgttccca aaatattttc ggaaatcatg atccagattg cccaacataa
     2521 atccgaccaa aaatggtaat accgctccca caaatgtttg cggttcaaaa acggccagcc
     2581 cggtgctacc caaaataatc atggtcacca acggacccga ttccagtgac atcagtacaa
     2641 atgctcctgc ctcttccttg gagccatact gctgcataat agaggcatat aacccgccgt
     2701 tcgtcatatc catagccgag atcagcgcaa gcaccgacaa acctgcaaat agcccacttt
     2761 ctataccacc aacaggcagc aatctggatg caatgatcgc cactacccac gcgaccgcga
     2821 ttttagtcaa tacgagcgtt cctgatttac gcaatacagt acccgtcgct cgcacatcta
     2881 tagaagcacc catacaaaaa aaccacactg ccaagatggg taccgtacct gtcatcagcc
     2941 ccttggtaaa agatccaaaa tagtcgcctg cccatggagt aaatgtatga aaaagtgcgc
     3001 caataaacag cggcaccagc ataatgcccc ctggaatttt atcaatgttt tgtttgattt
     3061 tcataacttc gttcaaccct ttcgtttttg ccaatgcaaa aacaaggccg tgttacttgc
     3121 ggctcaagcc gagctcggga atcagtctcg cgaaggtatc gtgactctcc ttcagttgcc
     3181 gcgcgaatgc ctctgcatcc tgtacacgca atcccaaccc atgcttacgc atttcctccc
     3241 tgaattcctc gtctttcgtc cccttgatca gtgcatccgt cagcgtttga gcaacttcat
     3301 ccggtgtatc cttgggtaca gccagccctc tccaagtgcc gataaaatgt acacgcagcc
     3361 cagtggattg ctgtagtgtc ggcacttttg gaaacgcttc cgaaatagtg tctgcctgga
     3421 tcgccagtat gcgaagtttc ccttcgtcca cgtatttctt cacttctgcg ggactgacgg
     3481 gtacagcatc cacaaatccg ctcattaaag cggagacggc tgggcctgct ccctcataag
     3541 ggatatgggt aaagcgaact ccgcttttct gctccagcat cgcggcagca aggtgccata
     3601 tgctccctgt gcctgcattc cccattttaa gcttgccggg atgggcgcca gcatcctcca
     3661 gaaatgcctc cgctgtcttc catggtgcat ccgcccggac cgtaatggcg gaagggtcca
     3721 tattggtttg aagcagcggc ttaaatcgct cataggtgag cggtagcagt cccaaatgag
     3781 gcaacgtagt cagctcagcg accagatacg ttacggtata accatccgcc tgcgcctcag
     3841 ccccttccat tagcccgaca gaaccgcctc ctcccgttcg attaacgacg atgatcggct
     3901 gaccgagatg cttttcggcg gctttcgcca acgctctagc ggtaatatct gtaccgcctc
     3961 cggctgcgta aggaacgacg agtgttattg gcttcgtagg aaatatacgg ctgtgatcct
     4021 gcagggtgcg gtgatccaca tattcactga tactcaaggc agaaagcata gctactcccg
     4081 ccgcaaccag cacatatttt tgccatggct ttttcttcat tacgtttcct cttctccaaa
     4141 aatgaactgg gcccgtcatg cgcccgtttt cacctccaac gttttcggtc ttgttgttta
     4201 cgtttacatg aagtcaatgt accgcaacgt ggagggctac agctatcgct taatcttcgt
     4261 atttatcttc tatttcgcca aagtatcgac cttttgaccg atctgcatat tcattggaag
     4321 atttgctgat ttgtctgaat ttccctgggg tcacttgttt gtgcttgcgg aatacccgga
     4381 taaagctgtt ctcatttcgg tatccgacct gttctgcaat ttcaccgatt ttcaaatggg
     4441 tttcacatag taatgtgcat gcctttttta cgcgtaatcc agtcaaataa tcgtaaacgg
     4501 tggtccccgt ttcttccttg aacatgctac tcaccgagga cacgctcatg tgaacatgat
     4561 ccgcaatttc ctgaagcccg atgttcaaat gtaaatgatg ttccatatac tcgatcatct
     4621 cttgtacacg cacaaaatct ttggactgga tgcgtccatt ccatttttct tcaatatcag
     4681 tcaacataat gaccagcaat acctccatgt cttgaaggtc tagcgtcaga atctgattcc
     4741 agtggtaatc agcaagctga tccggcggcg tcacactctg agtggcacac cattttagca
     4801 aatcttccag caattcatga acaaacaagt agacctgagc tggggatgtt ctgtggagtc
     4861 gaagttcttc tacccagtgg ctgattagct ttacacttgc accaggttcc tgtgactcca
     4921 gggcacggat catttccaca cgccgattgt ccagcaatgt tgaatcctga atctgctcct
     4981 ttgactgttt atccaccgta ttatcctttt tcacacttat actgctgtct atattcgtat
     5041 atgaacgtcc atacccctca tacaaacgca aattaagggc ctcttttcct tttataaaag
     5101 acgcccgtac ctctcgaata tccgtgacca tatgaccaat ccctatagaa atagtcaaag
     5161 gaagatactc accgacaacc tgaataagcc tatccacgct tttttgaagc aaaatgctct
     5221 cttggaggtc agtctctgta ccaacttcat tcgaactctc gctgaactgt agcagcacaa
     5281 taaaaccact ttcctcctcc ggcgagcata ctgctttcca gtgaggttcg agcatctcta
     5341 gcaaaatatt gttcagagca tacttgagca gcattttatc ttcttctgga aagcttgcgg
     5401 cccacgcaga ataccggtca atggacacga tcatgacaaa caaagaatgg ccgtcccaat
     5461 cggaaaaata ctgttcccat ttcatacgca tttcctgtat gcccattcta cgctggatga
     5521 catcttccat atatttggaa cgcagctccg gcaggcttcg ctctaccacc aatgatttgc
     5581 ggtgaaactc tccaaccagt tttctaatta caggttccag gtcatacaat cctccttggc
     5641 gcgttccctt attgcccgaa ttcaataggc tattaatttt tttcatggga cgaaaagctg
     5701 cataattata atagtaaact gctgagcacc cagccagtat ggagacaaag gccagccaca
     5761 gcatcatatt gcgcgccagc tttacatttt tcagcagctt gtccatcgga acgagcgata
     5821 ctagacgcca gcccgttaca tcagaaaagg tttggttcgc catatattcc atgtccccta
     5881 tctctacata agcataggga ctcacatcca gttcttttaa aatcctgccc atatcattta
     5941 agggtaagga cgatctcagc ttgggataga tcaactcgcc ctccagatca tacacgtatt
     6001 gcgagttgga taaatgaata tagagtttgg agaaaaaacg gtcataatcc agattgatta
     6061 gcaccgcacc catgacctga ccattctcta ctatgggcct ggccagcgaa agcagctcta
     6121 ccgccccctg ctcatgatcg gtgccgtacc atctccgctt aatcaacaac ggcttttttt
     6181 caatgtcctg aatccaggga acccatgtgg tatccggtgc ctgtttccaa tcaggcctgt
     6241 aaccataatt gctggatacg agagcatgat tgtccaaaga aataacttca accgagtaaa
     6301 tttcttcgtg cgaagaaagg gttttcaagt atttgtgaag ccgatctatg acggaggcct
     6361 tgtcttccag cgattcccca tctgtttgga cacgtacaaa ggcctctacg tctggatgat
     6421 atgctgcgtc cagcgccttg ttatcagact cacgaaaagc ccgattggtc acatccagat
     6481 tgatttgcag caattctata ttgggtgtgt tcagctcggt atccaaacct tcacggtatc
     6541 gtgaatacga tagcaagccg atcatgctaa ttacaagcga cacgcacaga gtgagcagta
     6601 gaatcaatct tgtctgttta tttttcagta tcaatcgaag cttaagtcgc aacattcccg
     6661 taacttcatc cttccggact tggttgtcca tcttcctctt gccaatatat gtggtgacat
     6721 attctcccta aatctatttg acgtaagagt tggaattccc tgcctatgta tatcaaactt
     6781 aatataagga ttcatataaa aaagaagaag cctccctgta ctgtacaagg tagaactcct
     6841 tctttggcac tgcttgtatc attattcagc aaaaacagat actcgctgca caggttttag
     6901 cttgtctatt ccacctgaaa acgatccagc tcccgctgca tctcttcgcg aatctgacga
     6961 agctctttta ccttctcagc cgattcctca aatgaacgct tctgctccac cgtggaagct
     7021 gtaatctctt cactgcctgc ggcggactgc tgagtgattg cgctgatatt ttcaatagct
     7081 tgctgcacct gtacgctcag ttctcgcgat acattcatgt ccgttgatag cttgctgact
     7141 tggctggcaa tttgctgcac tttgccacta atctctgtaa acgattctcc agtcgaggag
     7201 gttaccttct cctgctcacg gaacagctcc tgactttgcg ccacagaagt cttcacctta
     7261 tccatagcct gcgtgatact gtcaacagca gtataaattt tctttacagc agactctgac
     7321 tgattcgcca gctttttcac ttcattggca acaacagcaa aaccttttcc tgcttcacct
     7381 gcacgtgcag cctcaataga agcattcaag gacaacagcg atgtttggct ggcaatttcg
     7441 gatacgtatc cagtcatggt tgtaatctcg gctgcattcg cctccagctc cttgaccgtc
     7501 tgctccactt cggacatggc tgaacgattt tctgcaacaa tacgcagttg atcgctcatg
     7561 acccgcgtac cctgctcaat gacacgcaaa gcatcctcac tatacgcggt cgattgtgtg
     7621 gtctccagta gattcgattc aaacttctgc tgcatctcgt ccacaacgcc aactgtcgac
     7681 gacagatcct cagcaatttt ctgactgcct attgccagtt cctctgttga cgtgctgact
     7741 tgtgtcacaa tttccttcat ggcctcatta tgctgatcaa tatcccgagc catcagatcg
     7801 acacgattac ccgcctgatc aatggagagt acaatgctgc gcaagttccc gatcatcacc
     7861 cggaaagatt cattgagctc gtccagctca tcgcgtccct tggtttgggc aagctgcact
     7921 gtcagatttc cctcagcaat ttgctttgcg gcatccgtta atttgcgtgt tctaagggca
     7981 agctgcctgg atgtatatgt attatatagc ccaaccgcca ccagaagtat aactgcacct
     8041 gccaaggcca attgccatgt aaaacgaatg ctcttggtca aatcttctgt gtattggtca
     8101 taacgtgcct tggtcagcag atccagcata aatacatcgt tctgaatccc ttgggcacgc
     8161 atggcctccc gcttggactc cgggctgttt tgggtactca tggctttctc cgttgctact
     8221 ttcaattggc tgaattttgt tttaatcgta ttcagtcgct tttgctgcgc ttcggtttgc
     8281 atcatgccct gtgaaagcaa agcaatcgtc ttttcagact gagtcagttg attttgcaca
     8341 tcggctttgt tgctctccgt catggaagct gaataatttt gcagtgcctg ccctgactga
     8401 atcaaatagg cattgagctg ctgtacattc aacatagccg gaaccagatt actactttgc
     8461 gagttaatac gaattaattc aaaaatgata taagccacta aagctaggca agcaatcaag
     8521 gaaatcatcg cgttcagcac cagtttacct tgcagtttca tcagctttca tcctccgttt
     8581 gcgaaaattt attgggtggg aacagtcagt gtgccggatt tgattttttc ctttaaatca
     8641 tccaacaact tttgctgatc cggactcagt gtcacgacac gaataggcgc caaacctaca
     8701 ccatcttccg caagaccaaa caccatatcc ttctccgtaa attttctttg atgatctgca
     8761 aatcctttga ctgctgtata aattgcaatg tctacatttt taaacatcga ggtcactacc
     8821 gctttttccg caataaaaaa ctggtcgcta tcgaccccga tggcgaattt atgctgcttt
     8881 tgcgcttcct gcagcgcacc tacgcccgta agacctgcgg ctgcaaagat gacatcaatc
     8941 tgatcctgat taatcatgtc atctgcaatt tccgtaccca gttccggctt tccaaaatct
     9001 cctgcatacg ttgcagtaac tttggcatta ggcttgactg attgcactcc tgcgcgatac
     9061 ccaatttcaa attttttcaa cagaggagat tccgcacctc cgagaaaacc cacctgttcg
     9121 gtgcgactcg tcaaacccgc aacgactcca gccataaaac tgccctcttc tgctttgaag
     9181 ctaatagagg ccacattcgg taaatctgat ttctcatcca cgattaaaaa tttacggtct
     9241 ggatattttt tagcaatgga ttccaaactg tccttcacca tgtaacccag cccaatgatt
     9301 aaatcagcct tttcttgagc aagctgttca aaagccgcat catacgtctt ggtctccgtt
     9361 atttctcggt attcaaaaac aattttcccc tcatcccgtg ctttgaccaa acctcggaaa
     9421 gcagcgtcgc tgtaagattg gtcacccaga ccaatatctg acagtacgat tcccacctta
     9481 atgggctgag ccttggtttg tgctgccgat tgcccacatg cacttagcaa taatgcaaag
     9541 attgtgacaa tgggaatcca cctaaaattt aataatacag ctcgcttctt catgacatat
     9601 cacctcagca taatttggaa atccccaaca tctttatatc ggttatagaa gcatattttt
     9661 tcataagagt ttctgtaaat tcattgtaaa aggaagagaa gacgcgggaa agaaacagtg
     9721 tgcccatcat tcttttgtct ctctttcact atgcagaaat caaaaaaact gacacgtttt
     9781 tcgtgtcagt cagagtgtcg agaaagtcca gaggactttt cgacaattct atttttatat
     9841 ggggagacgc atcttttaaa acaaaaatcg atttaaaacg atctgaggac cctagttttt
     9901 agaccactaa gacagtttta aaccccctgc aaaaaaacag ggggtttctc gacagcctga
     9961 ctgacacgtt tttcgtgtca gtttacctaa ataataatag ttaacgaatc attaatacag
    10021 catcccattc tggacttcta tcgctaatta atgaggcgag gacaagagca acacctgcag
    10081 tcccagttaa aaaacccgct tcatctatgt ttctataatc tccattcaga aaatttatat
    10141 cgtaataacc aaatagggaa gatggctcaa ataaatccaa tactcgctcc acaagcaaat
    10201 cacgcagtgc tcctagccgt tcgttgcctg tatcggagta cattcgttga agaagatgga
    10261 gcaagcctcc aataccgtgg cataccgtag cagaaaccat cccaccattt cgctctattc
    10321 gattttcgat gtccagataa gccttcaatc ccaaggatat ccattcatca ttctgtaaag
    10381 cctgtccagc taaccaaatt gagcgcgcaa ttcccggagc accatagcac caagaatccc
    10441 tttgatattc agtgttttca acggataatt cagattgttc ccattcttca aaggatacct
    10501 ttccaggcca tatcgttcct acctgacttt caaactgcca tttagcgagc cattccgcca
    10561 acgtggctat ttcctttttt acttgttcag ttgtaatccc ctgtaagacg gatatactca
    10621 ttaatgctag tggtcctgct ataccatggg ataagcttag attaaaatta cctttaggat
    10681 attgcctctt ctcatcctgt aaaaactgat tctctgcacg aatatgccaa gcgggaatac
    10741 attgtccctc ccaattttta tctccgcaaa aaagctgaaa ccatacaaca atttgctccc
    10801 atagctcttt catttttggc cgttcgtaaa aaagaagaac aatacgaccg atacctgtaa
    10861 agcctaaaat tgtatcataa tcactcattt tcaggtaccc cgaatgccat tgtttcatat
    10921 ataatggtat tctttcagct gctaattctt caaaccatga ggccacttga ttcaacatag
    10981 actggtatcg tgttccatcc cgtgataacg cccgaatacc tattagcaca cctgctaatc
    11041 cactatatag ggatagatca tacatcccca tttcttccat ctgtttttga agcttttcta
    11101 aatacatatg ccctatccga tcccatccat tctccggata taacagatcc aactgcgcca
    11161 ataataaaca aattcctgga taaccattac ttaaagtccc atcattccat ctttctattt
    11221 caaatccatc cacttctagt ataggcatgc ttttagaacg taaacaaacc tcttccggat
    11281 ttttgtaccg ctctccgatg gaatctagta ccttgaccac tcgttctctt atttcacctg
    11341 acaagggacg ccatgaacta aatggcaatt gagcagatgt catgactgaa agacacctcc
    11401 tttgttcgtc acagtaccag cagcaaatga actggcttgt acctgataca tttctgaata
    11461 gacaccacct aatctaacaa ggtactcatg ggttccctgc tctatgattt ggccatcctc
    11521 cataacaaca atgtgatgag caagtcttgc agacgaaata cgatgtgtaa taaaaattcc
    11581 aattctctcc ttcattaaat ccaaaaagag ttcaagcaaa tcacgttcgg ctacaggatc
    11641 caaaaaagag ctcggctcgt ccaagatata cacatccgcc ttcctaacaa aagcacgcgc
    11701 tattgccagc cgctgccatt gcccccctga aagctgatgt ccttcttcaa accatttacc
    11761 tagttgagta tttagaccat gcgatagctt ttggatcaca tcatccatag caacatacct
    11821 cgcggcatcc attaatgtcc tatcatcctc aagttgttcc aaatctccaa aacctatatt
    11881 atggcgagca gacatttcat actgcataaa atcctgaaat actgctccta tttttcgttg
    11941 aatgtccgct agttcatagt ccttaatatt acaaccattt acactaatcg ttccgctgta
    12001 atctgcatac aattgcatca agattttcat taaagtcgtc ttaccagatc cgtttttgcc
    12061 tacaattgca actgtctcac ctttggacaa tgacaatcta acattgtgta atgcatatct
    12121 ggactgtcct ggatacttga aagaaacccc ttcaaatgaa atctgttcaa tacggaaatc
    12181 atgtcctgct cctgaaggtt gcatgtaatt tagttttttt tggtgatata caggatctga
    12241 ggtgggtaat ttcaaaaata aaaacagttg ttcaatataa agattattct gcgaaaattg
    12301 taaaatacca cgcatcatca tctgaatttg gctctgcgtt aacattatgg cttgaatata
    12361 cccgtataag ctaccaatca ttatgttagt aagcagggtt tccttcattg ccagccatac
    12421 aaaccataac attactccaa gctcaagcaa gttatacatc aaagtaaacc gggtaagcct
    12481 acctaacatt cgacggtcga ccttaaaaaa actttccagt aagttggagt aacgttccaa
    12541 tagatatggg cctaattgaa aaattttcac ttcttttacc gcacgatcat tcgttaataa
    12601 ataagtcata taccaagatt gtcgatactg tggagtccgc tccatgtata tttggaactg
    12661 ttcacgatta attttgaata aggaatataa agataccact gatacaatta atagaataag
    12721 aacaatccac catttccata aaatcaacca aattgcagag gatatcatag taatgaggct
    12781 tgatacaatt cccgccattt gagtgtaaag ttgatacgga cgataagaag cctcttgaga
    12841 ggcacgtttc aactggtcat taatagtcgc attttcataa tcagctaatc ccaagcgagt
    12901 tgatttttca caaatcataa tatttaatga tttggaaagt acagcttcca aagttccttc
    12961 cacataaccc tgtgcggcat ttactatatt tttcacaaca taaaccagca caaaccatcc
    13021 aaacggtacg attactaaac cagctccttg ttgcaaagca actgaaactt tgtttagtac
    13081 attctgcata acagccaggg tgaaaatcgg cgtaatccct tgaataaaat agaacataat
    13141 actaagaacg agataacgtt tattagcact agaaattagc cgaagcagct taagaccact
    13201 cttcactgat ttccaagcag agtgcaatcc attattttta ttaaccatat ctttcatttt
    13261 actttcctgt gatagtgaac gaggctattc attgcatgac gagccatgat catgattttc
    13321 cgttctctat atcgatcaat tccaagtaag cgattcaaat gcatgtgaat gatactaaat
    13381 aaaatatcat ctttagtatt cattaaagaa ctctgcttct cttgttctaa aattttttgt
    13441 tgataacaaa aagctgttga ttccctgatt ttaaataaat ctagaatatc attgatttga
    13501 ttctgagatt gaccttcctc ttgtgtaaat gttttatcca aaaactgcaa ataaagcctt
    13561 cgttctttgc gaaattcact tagaaactcc tttacgttat atttttgatt gagaacgtcg
    13621 taactttcgg cttcgttaaa acctaattga cgcaacaaat ggattacact caaaacagct
    13681 acaatatcta aatctaattt attttgttta aaacggttca aacgaataag tctagcggca
    13741 atctcgctat catcagcgaa catggactcc gctaacccca ttaattctgg ccctccatag
    13801 cgctcaattt ccggttcata ggtatcaata acaaatttag tcatcaatcc ttctcgtatc
    13861 catacttttg cccaatcatg aaacatggta aaaaaatcag gaacaaattt ctcactagac
    13921 attttgaatc ttacacgaat atgggattct ggatccgcat aacgaatata atagccatat
    13981 tcaactatac ccgtctcctt tgcttgccga atacactcat cccaatacaa accaataaac
    14041 tcattttgtc tgctttccat tccgtacagc tttgcataga accatacacc acctggaaaa
    14101 tgtacacgtt gagccaaact tactgtctgc atagaagtag ctgatcctac atcttctgaa
    14161 gctgccgcaa cctcctgcag agtacccgaa gaagtaactg gccgtcgaac cagaggaaat
    14221 acgaattccg ctgtcagtct accttcacta caataaatag gtaattgttc aaatccacca
    14281 gtaagttcaa taagtacaat tgagttgcca gattttaatt ctttacatag ctcttcgatg
    14341 tgtaaggggt gctccaaatc taacaaaata cgatgatcag attgaatcag gtagacgtgc
    14401 cgaggtacct tccattctaa acagaattgg gtaaccgctt ttttcagggc ttccgtacct
    14461 agtggtttgt ctttgtcctg acgaaaccac attctccatg tcgccggagc aaaaatgata
    14521 ttattgtacc gcaaacgagg ggtaaacgga gcctgcgtca tgattcccca gtttactgtg
    14581 ttccattgtc cgaatccagc tagaccgacc tcaatcaaga accggtatac attaggagct
    14641 tggtggtagt tgagcatatg tccggttgtc ggtatgactt ctcgattgtg cttgcgtgat
    14701 tttaagtaga aatgatcgcc acgtagcccc acaactaaat ccgatacttg aatttgccga
    14761 tcatccggca gagcctgatt ggtcccgatc gcaatctcat agtctcgaaa attttcaaca
    14821 agaataacat tcgttgttct tccagagctg ggtaaatagg atacttcagc ccaaattttc
    14881 tcagggtaca gactttgctc ctccagatga atagcttgga attccttttt aaacggtgta
    14941 ccgagcaaat ccataaaacg tccaaacgtt tttcccgcac cattcgaacc agggtttggt
    15001 ccgaggagca atgtgtattc tcctcgatca agcgcctgct ggtcgcgggt attcaataag
    15061 aagtataatt ccatagaagg caatgtcgga cgggttatgg agtcctcagt atgtgtaagc
    15121 tgcccaatca tttcatccgt aagattcatt tcataattgc ctttatgtat ggaggataca
    15181 aaccattgaa aaagaagctg ttcccgattg gcttgcgttt tggcaatttt ccctgttttt
    15241 aaggatctgc gtcggctctg cggatgacgg taggtcgcag gcgcacctaa acccatttct
    15301 tcatctaaca gttcaagcaa cggtacctcc cggccatatc catacttttc taaaaactcg
    15361 tcagtatatt ccttgagatg agcatccgtt tgggaagtga gctgggaaaa taattcggcc
    15421 acccgttcaa catccttacg gatatattca ttcagaacga tagaatggtc ctccaccgat
    15481 aaatcgacct gtaaagtgga catttcaatg tccgaaactt cactcatcac ttgtcgcagc
    15541 agctttaggc gctcctcacc ttccccaata ggaagctcat tgtacagacg gatatcctgg
    15601 tgaatacttt gcaactgcaa ctttagatcc tccataccgt ataacggatt gataatcgcc
    15661 aaaatttgga caaaaggatc tgattttata gtcgagggtc gtagctctga aataagaaac
    15721 tcttgctcaa aaagctgccg aatataggga tcaactcttt cttcacccgc ttccgaaaaa
    15781 cgctgcataa caagcttaac caatgttgaa aataataccg gttgtgcgca gacctccata
    15841 atataatcaa atacagcgga tgccttcaca gatacgctat cgttctcccc gtttactaat
    15901 tttccgtatc tggtagtgta aggaattttt gcccggtttc cttgccgata gattaaagga
    15961 ttgctctgga gacgaagctg gcataacact tctggaatgc tttctatctt ttcaataatt
    16021 tttaaagtcc attccatatc gggtctcgcg cgtttgcgat gagcatgcgt attcttgaga
    16081 tacaattgag aagactcacc gaagtgtccc acggaaacgc ctgagaataa accaaatggc
    16141 gtcggacggg tcatcattct tagtaaatac cgcatgaacc ctttaagtac ctgctcttgc
    16201 ttgcgcggat catctacatc ttgcagacga aataaggatt cgtgtaagct cggactggaa
    16261 acggcaattg cttccttgat tgcgggatcg ttggataact caatcatacg ttgcacagtg
    16321 tatgatttga gatattcctt gttttcacat ttttcaggaa aaaaagactt atacctatca
    16381 aaagaaatta caggagttcg cagtaaaaaa aaatcgagtg ctttgtatgc atatcgctga
    16441 cgcttcatta ttcctcgccc ccggactatc ttgtatatat gcactttcaa aggataattc
    16501 accttacaat agaagaaaaa agggacttaa aagccccttt tccttccatt tttctgttcc
    16561 gcagtcaacc aaatactctg aatgatgaat gcatcccaaa gatataatat ctcagcacca
    16621 atctccaatg tttgatacac aattcccgta ggttttacca caattctccg tgcgctgccc
    16681 cccgcatgca acagcagaac acgccgctat gcttgtaaga acttgtggtt caacagatcc
    16741 cttagactta ttcacttgta catccaaatc aaaagcatcg tttgccatgt cattttcctc
    16801 ctctcgttca acttgttttc atagatgtga tgattatcac taatgatttc tttctgctat
    16861 ctcttagaag ttaatttata tgaacaatat cccaactgat cgtcatctgt tggaatattc
    16921 tcatatacat atttactttt atgcttgttt aggctatcaa ctgctagtta cttatgtaaa
    16981 aaccataacc taaacttctg taaaatttgt atataattta tatacaaaca aaaatatata
    17041 accctatgcc taaggaatga aaagtgaatt ttgcacatta ttatatcttt tgaatttatt
    17101 aagaacaaaa tacatttata tcaattttca ttcttataaa tatatagctt aaagctttct
    17161 aattctaagc acattacttg atcccctcct ctctttgttg tccacaccat tcaaacccat
    17221 ttatttatat gtatctagcc atatagttaa gagtattaga aaagggacag gaacacctgt
    17281 ccctaatccc cgtttcactc cccgtgtact cctatttggt tttactccat ttggaagcaa
    17341 ccacgtcagt tttactttct attcgttcca tgacctcctc acgacgtttg gctttgaaca
    17401 ggtcaatcat atccatcaaa tcattgcggt ctaataattt aaccccgttg acagcagcaa
    17461 gtgttttaca ggattccgta taacggccgg aggtgatgac gacagacttg tcggccgcat
    17521 aataacgcat agaggtatag atctcctgca ctgctcccaa acctaccgga tgttgtaccc
    17581 cataacgttt ggcctgtatg acaactctga cgccttcacg gtctgtaaaa accagatccg
    17641 ctccaaaatc ccggctactg gttgttttat agatatcctt atagccaagc gcggataata
    17701 gccgctgcaa ataaagctca aattccgacc catcctccat acgatctata tcctgaattc
    17761 caattttgcg cgggtccaga tcacgtaaaa tccgatttct gcgaccacgt atcaatcctc
    17821 tgatgatgag cgcaaacaac actaaaagta caatgagtcc tattcctaat tccttgtatg
    17881 ccaataattt ctctagcaac atccaactct cccttttcta ccataagcgt agccgtatca
    17941 tccttaacag ggaacttttc tatgcacgct ggctcccgta ttacatctct ctttatcaca
    18001 taacaatagc cccgccagat tcgacggggc tatcttcgtc ttgcctcaaa gctgtctaaa
    18061 ctccatactc cgcatcatta ttcgcgattc agcaaagatt ctccggcaat accaggctga
    18121 gtcatttggt acgggtccaa tataatgtcc agctcctcct cggtcagtac attgtacagc
    18181 aagcacagct cgcgcaccga tttcccagtc gtaattgctt cgcgagcaat gcgtgatacc
    18241 acctcatatc caaggtgcgg attaagcgct gtaataatgc ctacactgtt ctctacatat
    18301 tcacgacaac gctccacatt cgcttcaatt ccttccacac aatgaatgcg gaagacgtgg
    18361 aagccctgct tcataatttc cagcgattgc agtaggttgt acaccagtac gggttccatt
    18421 acattcagct cgagctgacc agcctctgaa gccaagcaga ttgtatgatc attaccaatg
    18481 acctgaaaag caatttggtt aatgacctca cacatcaccg gatttacctt gcccggcata
    18541 atggatgacc ctggctggcg ggcaggcaga ctcagttccc ccagacccgc acgtggtcca
    18601 gaagccatca aacggatgtc atttgccacc ttagacatat tcatcataca aattttcaag
    18661 gcagcagaca cttcagtata agcatccgta ttttgtgtag catctacaag attttcgtca
    18721 gcttccacag ggaagccact gacgtctgcc agcacctctg cgacacgctg aatataacga
    18781 cggtctgcgt tcaggccagt acccaccgca gttgcgccca tattaatcgt tagcaggtgc
    18841 tgcttggtcg cacggacgcg tccgatatca cgacccaaca cacgcgcata agcctgaaac
    18901 tcctgcccta atcgaatcgg cactgcatcc tgcaagtgag ttcgccccat tttaatcaca
    18961 ctatcaaact catttgcctt gcgggaaaat gcttcctgaa gctcactcat ggtagctaac
    19021 agcttatcaa tcatacttaa tacagccaag tgtacggctg taggaaaagc atcattcgtc
    19081 gattgcgcca tattaacatg attattagga ctgatctcct ggtaatctcc gcgttgcttg
    19141 ccaatcagct ccaacgcgcg gttcgcaatc acttcatttg tattcatatt aatggacgtg
    19201 cctgcgccgc cctgaatcgg atcgacgatg aaatgatcat gcaactgtcc ttgtataatc
    19261 tcatcagcag cctgaataat ggcctctgct ttggggcggt gtaaacgggt tagttccata
    19321 ttcaccgtcg ctgctccctt tttcacgatc gccatggctt taatcaactc agggtgcagt
    19381 ctttggcctg taattggaaa attttctttt gccctcagcg tttgtacacc ataataggca
    19441 tctgatggca cttccttggt acctaaaaaa tcatgctcca acctcatatt ctctgattcc
    19501 tccgctgtgt ttgctacgtt tcttcaattc agtacagcca aattgacata aaaagacctt
    19561 ctctgatccc ctcttcatta tacgtttcta ttcccgtgct tttccagttg aataaacgcg
    19621 gaaaaagcta tgtaatccta tgacaagtta tgattacccc tatataccac acttattcgg
    19681 taaatgctca gctatgactt gaatacggat ttaatgactt ataataatat cgagtggcat
    19741 gaagctgacc atcggctgat tgagcataac ccggaataac accagcttct acaaacccga
    19801 tcgcctcgta tagtccattg gagggatcac ccacccgcgt atctagcacc agtaacgttc
    19861 tatcctgact tagtgcctct tcttccgctg ccttcattaa ctgtcgtgcg atccccagtc
    19921 tgcgaccgga cggatgtacc ataagctttg caatttccgc acgatgaata gcgttagctt
    19981 tttgagccaa atgaagctgg accgtcccta caggtactcc gtccttctcg gcaatccaca
    20041 gaactacgcc gtcctcaagt acattgttcc aataagttgc tgcttcctga taacctaatg
    20101 ggggtaagaa acctatagat gcaccgtctg caaccacgtc gattaacagt cgacttagcg
    20161 aatctaccag ggcttcatcc agagcttgaa cagggtagac tctcatttcg ttagacattg
    20221 tgattcctcc cgatgggttc gataatatac aataaagaaa gcaaactatc tttttaggat
    20281 agtttacttt ccataatact tcgcttactt catcattctc atttccatta ctgctctgcc
    20341 atataaaaga actcccacag atgaccatcc aaatcctgaa agctccatcc atacataaaa
    20401 ccatgatctt gaggttcgtt tgagggcttg ccgcccgctt ccaaagcctt gtggacgatc
    20461 tcgtctacct tttctcgact ctccaccgat aaggcaacaa ttgcttctgt gctttttgtg
    20521 gcatctgaaa tttcctttgt cgtgaacgct ttaaaacgtt cttcaaccaa taacatgaca
    20581 aaaatatgct cactaacaac catacaggtt gcatgttcat cagtgaactg agcactgaat
    20641 tcaaatccga tggtagtgaa aaaatcaatg gactgttgca gatttttaac tggcaaattc
    20701 acaaaaattt gtttagcttt tactcccacg acatttcacc tcttcatttg tcattcattc
    20761 taatttatca tactacctct ccacaaaaga taacttaact atcgtataaa gtcaatcaat
    20821 ctgacatttg tatagggaaa tctcctattc ccaatgtagc ttatccagcg tgcgagataa
    20881 tacagccgca gcttctgccc tcgtcacgga tgtagccggg ccaaaacggc ctttctcgtc
    20941 tcccctcaga atacctagtc cagacaaagt cttcacagcc ggagctgccc atgtagaaat
    21001 ctcctgcgca tccgacaatg atacggatat actttcactc acttctcttg tattttcttc
    21061 tgtgttccca gcgaagcgca aggctctctc tatgatcaca gccagttcct ccctcgatac
    21121 cggggtatca ggacggaagc ttccgtcagt atagccgttg atcagcccag ctgctgctgc
    21181 ggtacgtacg gaatccgcat accacgattc gggttgaacg tcgtcaaagc tcgtcagcgt
    21241 gcgatcagta cgctccagtc caagcacacg aaccagcatc gctaccagtt cagagcgtcg
    21301 tacctggcct tcaggctcaa aatgcacgtt cgctaagtcc ctttcacgag tcgcagtagc
    21361 tgtagacgct gttgaatggg tccccgtcac aagcaggcga gttgccagcc gtgtaatgtc
    21421 ctgctgcgcc caatggccgg atatatccat gaacgatctg acttcaccag aagacccgcc
    21481 atcaagcaca gcgtaagtcc ctcccgaacg tccatacacg gttatttcct cactcgaagt
    21541 gtgaaaagga acgggttgat aggacagctg tccgacttgg ttggtcgatg ataccttcac
    21601 tacagcaagc tggtctgtat cgaccattgc aggaacacgt aacagataac gttcataccc
    21661 tctaccagag tctccgttac ctaccaaaag ctgtttccgt ccatcctcgc ttctcagctc
    21721 agcggcgata tccaaagcct gtaacagtgt acgccctgtt ggaacatcca agcgtttagc
    21781 cagctcttcg ttcgaagcga tggaaaaatt caaagaaatt tgttttacag gcacctgcca
    21841 ggtatcagcc agtttctgaa gagacaagcg acttgttgtt acttcatatc caccctgtgg
    21901 cgtttccact cgaagggtac gaatacggtc gttcaagacg gctcccaaag cttccccgtt
    21961 taaatgaacc tcgtacgtcc ccgcttctac ttgctcccct gcacgaatca caagcgtacc
    22021 cttcacacca ttttgaatgg ccttttgtat ttcagcagtc gttacttgag cgactgcctt
    22081 tttcaagcca ttttgctcca ctccggtcac tacagacctg acttgcacca catttgtacc
    22141 agacaggctg cttccattgg gttcaccact ggcggtctga ccctgcccat ttaccgttcc
    22201 attcgcgtta ccgctactgc catttccagc gttggcgttt ccctcgttat cctgctgatc
    22261 ctcctcatca tcgtcatttc ggccactccc actatctgtt ggtggttctt ccgctttgcg
    22321 cggcaaatct atttgtgcaa ccaacggatc atgatcgctg acccgcccat ccgccgcact
    22381 aaagtctgca ttcatatgaa cgatatccag cacggatgtt ttgctcagtg acgggctgac
    22441 cagcatatga tccaatgttt gcgagttacc ttcataaata taggagtacc gttccttttc
    22501 atccaaatgg tcaatcagat tggtcaattc ctgcccccgt agcaaagcca gcgtttccga
    22561 aaattgaaaa tcattcaggt caccgagcac caccatattg gccttagggt ttacttgcag
    22621 taccgacttt acaaagccat tcacaatcgc tgcaatcttc gcacgctgta tttcgctgct
    22681 tcgcacaggt ggctgaattc caccaaatgg cgcttgatcg ccccctttgg aattaaaatg
    22741 gttagcgacc acaatcacct gctggccttc aaactcaaat tcagcggcca acggcttgcg
    22801 cgagtcttca aatgacgcat tcaggggatc aatccgaccc gggttgaggg aaagtccctg
    22861 cactccataa gtgacagacg taactgaatc ccccttgggc ttgtcggtca gcgtaacacg
    22921 ttgcggattg tacaagaagc caacacggat gttgccaccg ggggcaccgc catccttatt
    22981 attttcaggg ccaatatctg taaaattgta ttccgggcct ccatgagcac gaatcgcctc
    23041 tatgagcaca cggaagcttt cggaagcgtc tgtggtgcca tcatctttct caccgttatt
    23101 atcctgtact tccagcaatc ctatgatatc cggatgattc aaatttacag cgatagtctg
    23161 ccccagctga tctatccgtt ttccatcacc gggatcaaag ttttccacat taaaagaagc
    23221 tactgtcagc ttacgatcat cccctatcaa acgcgtattg gctggctgga ggccgccagg
    23281 tacaacatcc ggcatacgct ctggcagcag cttataattg ctaaagctat agctcaccac
    23341 acctgtgata gaacccgcaa aacgatcgcc tgttttcaac ggtgtcgaag gcttcgcatc
    23401 aatcagaatc cgttgcgggt tcagacttct ttctgtcagc atgagtccgc ctgcctccgt
    23461 tacaacctca cctgtgtttg gaccgttaac aattcggact ggaatttcat agccataggg
    23521 accaatcaca gtggcatcct tcaactctac acgcatgcct tccaggcttt cgaaaaagtc
    23581 caagccatcc tcctgtggat caaacaccgt cattccgtca tgatccacaa cagatgtcgg
    23641 catcacacgt ccctgttcac ctagcaaaat tggagctggc aatggacggt cattggcaat
    23701 taccttaacc gaagaagcca caatttctgt ggtcgtcaag tcgattggct tgcttgcata
    23761 tgttctttcc gtgtattcct ttaccgaacc gctaaccctt acctcatccc ctacctgtgc
    23821 accgtgacta ggcttgtaca ctaaaatggc ctcggatgtt ttttcatcct gatccacttg
    23881 agcatccaac tcttggatat agaaactgct ccccttcacc atcgtgacaa cgccttcaat
    23941 atccgctact ttttgtcctt catatggaga acggtgtgct gccccctgta catcgtggat
    24001 gcgaagcttt ttaggaaaat agacatctgc atatacactt gcccctacag ttacgggtga
    24061 aggttgcacc tcttttcctg caaaagatgc aggctctgcc gaagcttttc cactggacaa
    24121 ccctgccggc cctccagctg aaagcagcag tatagcactg agccatgtga tcccgaacct
    24181 ttttaatttc gtaggtaata ttttttctat gtattcttgt ttcatcaaaa gatactcccc
    24241 tccccatttt tactatgatt acgcttacaa atatattcat cttttaagat accataaatt
    24301 agtcaattta gtacctgaat tatgtaaaat gaattcttct tgccgtagca tattcagatc
    24361 aaattattgt aaacttgttc taatacagaa aaaggtggca catacgctat ggagcatttg
    24421 cttaacgatc aggttaaaaa cattcaaatc agcggcatcc gcaaaatcgc caacaaagtt
    24481 gccgcattac ccggaaccct gtcattaacg atcggacaac cggatttccc tacccctgcg
    24541 catattatgg aagctgccca tcgggcgatt aacgaaggac gcacctccta tacacctaat
    24601 ccgggactgc cggaattacg agaagccgca gcggcgtttg tagctcgtaa atacggcctg
    24661 aattaccttg gacaggatga ggtgatcgta acgaacggag ccagtgaagc gctggatatt
    24721 accttacgca cgattttgtc accgggcgat gaagtcatcc tgccagtgcc gatctaccca
    24781 gggtacgagc cattgatccg cttgtcaggc ggcattccag tgtttgctga cacccgcaac
    24841 agcggcttca agctcacggc cgaggtgctg gagccttatc tgaccgaaca gacaaaagca
    24901 gtcattctcg gatatccttc gaatccaacc ggacgagtaa tgagtcgcga agaattggaa
    24961 gcggtcgcgg atttactgaa ggagcgcgat ctgtttatca tttcggatga aatatacagt
    25021 gaacttattt acgaaacacc ccacgtgtcc attgcagctc taccaggtat gcgggagcgc
    25081 accatcgtca ttaacggtct gtccaaatca cattccatga cgggatggcg cattggtttt
    25141 acacttgcac ccgctgaaat tacacagcac atggtcaaag tccatcagta caacgtaacc
    25201 tgtgctagct cgattagcca atatgctgcc ctggaagcct tgactgttgg tgtcgatgat
    25261 gcactcccga tgcgtgagga ataccgcaag cgtcgtgatt atgtacatgg taggctgaca
    25321 gacatgggca tcccgctgga gaaacccgag ggagcctttt accttttccc ttccatcgcc
    25381 cattttggat taagctcgat ggattttacc ttgaagctgc tggaagagca tggagtggct
    25441 gtcgtacctg gagatgcttt ttcttcctat ggcgaaggat acattcgctt gtcctatgct
    25501 tacggacagg atgtgctgga gcaagggttg gataaaatag agaggtttgt taggggaatt
    25561 gtgaggagtt aaggcgggag aggcgctacg cagtccattt gatcttccga tcgctgttgc
    25621 tgggggattc ttggattgga taaaacattt ataggtaaga atccctcagc aaaggcgaac
    25681 gctaccgctt ctccagattc aaatggcccg cttcgctcac tgcacgcctc aaagtcccac
    25741 gattctctaa cgtgtgtgaa gcatggggaa aagaagtaca atactcactg ctttacacgg
    25801 tgaataaaca aaacaggccc ttgaaccacc tacacgggtg gttcaagggc ctgttcgttc
    25861 ttcctctact ccctcacctg ggtgtgggat tcatgggtga ctagctttaa gcacggcgca
    25921 gcggaggggg cggaatggtg ctggacaagc aaagcggtcg cctttaaatt ccgattttaa
    25981 cctttaagta tttaatcaaa aaaatcggaa tttaacagcg atggtaagca ccatccgcca
    26041 ccgcagcgac ctttaaagca ccacccccta atcctcacgc cactccccta ctttaaatgc
    26101 attttgaatt gcaggaacaa ttcattgtaa tgagcgagca tgcgcttgcc tagattgttg
    26161 tatacttcca gcttgtctgt aatttcggac ggagggtaaa aacgctcgtc accagagata
    26221 tcttcaggca acaacttctt tccatcctcg ttgggtgtgg agtatcctac aaattcggca
    26281 ttttgagcgg ctacatcggg ctgcatc
//
