LOCUS       NZ_JAMXJO010000001     11104 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Nocardiopsis dassonvillei strain RACA_4 assembly, whole genome
            shotgun sequence.
ACCESSION   NZ_JAMXJO010000001
VERSION     NZ_JAMXJO010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardiopsis dassonvillei
  ORGANISM  Nocardiopsis dassonvillei
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6726007)
  AUTHORS   Elfeky,H.H., Hanora,A. and Solyman,S.M.
  TITLE     Bioactivity of bacteria associated with Red Sea nudibranchs and
            whole genome sequence of Nocardiopsis dassonvillei RACA-4
  JOURNAL   Mar Genomics 67, 101004 (2023)
   PUBMED   36521348
REFERENCE   2  (bases 1 to 6726007)
  AUTHORS   Elfeky,H., Hanora,A.S. and Solyman,S.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUN-2022) Microbiology, Suez Canal University, 4 Km
            Circular Road, Ismailia 41511, Egypt
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Assembly Name                     :: SCU_Nocdas_4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: GCA_900638215.1
            Genome Coverage                   :: 7.6x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024181525.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:43:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,838
            CDSs (total)                      :: 5,775
            Genes (coding)                    :: 5,721
            CDSs (with protein)               :: 5,721
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 51 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 4 of 54
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:23:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2441339
            Orig. end                         :: 2452443
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAMXJO010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11104
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="9"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..11104
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11104
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:6104](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6104)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            1264..2226
                     /locus_tag="NGM33_RS10495"
                     /old_locus_tag="NGM33_10495"
     CDS             1264..2226
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019609610.1"
                     /locus_tag="NGM33_RS10495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NGM33_10495"
                     /product="aldo/keto reductase"
                     /protein_id="WP_130394748.1"
                     /transl_table=11
                     /translation="MRTVPLTTDGPTVSAQGLGCMGMSEFYGPGDEADSLATLHHALDL
                     GVGFLDTADMYGHGANEELVGKVVRERREEVVLATKFGIVRDRGTGARSHRGDAEYVHT
                     ACDASLSRLGVETIDLYYMHRRDTSVPVEETVGAMAELVAQGKVRHLGLSEVSADELRA
                     AHAVHPIAAVQTEWSLWSRDVEDSVVGECARLGVGFVPYSPLGRGFLTGALPPVEELSA
                     DDFRRGKPRFSGENAVRNQDLLAIVRRVAVAHGATPGQVALAWVHAQAERWGLPVVPIP
                     GTKRRERLEENVGGADLVLSPEDLAELDTIADATAGARY"
     gene            2326..2790
                     /locus_tag="NGM33_RS10500"
                     /old_locus_tag="NGM33_10500"
     CDS             2326..2790
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013154379.1"
                     /locus_tag="NGM33_RS10500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NGM33_10500"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_013154379.1"
                     /transl_table=11
                     /translation="MTQLPMDQRIGHHLKRAEQELISAKHAVLRQFNLSVPQYTVLLVL
                     SEEPGASGAILARRCLVTPQTMSSVLATLSRRELIERKPHPLHSHILETRLSPSGQDLL
                     AKADEAAIRVEMRLSEAFSSEEEGEFVRFLSRCAEVSAETRTELADLGEE"
     gene            complement(3075..4130)
                     /locus_tag="NGM33_RS10505"
                     /old_locus_tag="NGM33_10505"
     CDS             complement(3075..4130)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019609609.1"
                     /locus_tag="NGM33_RS10505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NGM33_10505"
                     /product="3-oxoacyl-ACP synthase III family protein"
                     /protein_id="WP_130394749.1"
                     /sec_met_domain="fabH (E-value: 1.9e-95, bitscore: 318.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIAILGTGSYLPDEVVGNEPIARTAGVTDEWIRRKTGIRERRRA
                     APEQATSDLAAAAGRRALAQAGVSADRLAYVIVATSTPDHPQPATASITQHLLGARSAA
                     AFDVNAVCSGFVYALSVAEHLLRPHGEAYALVIGADIYSRILDYGDRRTAVLFGDGAGA
                     VLLGPAHDRGGVMGTQLLTDGDHHHLIRVPAGGSRLPASAETLGQGGHFFTMEGRGVRE
                     YVTRRLPEAVHRMLDGLGVDREEIRHFVPHQANGAMLEDVWPSLGLDNAHLHLTVQTHG
                     NTGSGSVPVALDTVHRAGLLERDDLVLLAGFGGGMSVGLALVRWSPVAARAASVVRSIR
                     SAGAAPVHAPA"
     gene            complement(4216..4965)
                     /locus_tag="NGM33_RS10510"
                     /old_locus_tag="NGM33_10510"
     CDS             complement(4216..4965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013154381.1"
                     /locus_tag="NGM33_RS10510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NGM33_10510"
                     /product="HAD family phosphatase"
                     /protein_id="WP_130394750.1"
                     /transl_table=11
                     /translation="MTLANGAHTPGTRGRGIAFFDVDETLIGPKSMFSFLEFHLGNGSR
                     PPGSYERAVARLRAAAARGVPRQDVNRLYYRIMAGESVEGLRAEGRAWFSEAGRVPGFW
                     HTPVLERLRRHRAEGDLVVLLSGSFFACLDPIAEEAGAHWALGTRPVVRAGRLTGEVLV
                     PMIGATKETAARAAAAVRGVPLSSCTAYGDHSSDLALLSAVGVPVAVGEDATLTAHAEA
                     NGWERVRSDRPGPGAAEGAPTLPSVNA"
     misc_feature    complement(4941..4959)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.08"
                     /tool="antismash"
     gene            complement(5001..6104)
                     /locus_tag="NGM33_RS10515"
                     /old_locus_tag="NGM33_10515"
     CDS             complement(5001..6104)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019609607.1"
                     /locus_tag="NGM33_RS10515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NGM33_10515"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_130394751.1"
                     /sec_met_domain="AfsA (E-value: 1.5e-22, bitscore: 77.8,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQMPVHHLLNGATDTVTAGPEGPALDYERTVDRTVVHRESLAEVF
                     VTDTQPLGGDAHAAAAQLPRSHAYYGDHLLRPRRHDPVLLLEACRQVGLAIAHTHYGVP
                     FDHKFVLTTLGITITRPELMTVGTAPCALRMLCSVGDKRVKEGRVVGYDARFRLFVGGT
                     EVGNAVVGLRFKSPASYEALRLGNRSGEPVPSTETFDFTVSGEVPAPYLVGRSNGDNVV
                     LTGLAGAGDTVSASLRVLPQHPSLFDHAQDHLPGMVLIEAGRQLALNTLLEVRGTSPAK
                     AYPTEITATFTSFGELEPRTEMRAVTAPAEAEGTGEEGVYYTQGGIVEFLAPTGGPEPA
                     PTSVEVDVLQRGASICRIEVGLVRLPA"
     gene            complement(6280..7752)
                     /locus_tag="NGM33_RS10520"
                     /old_locus_tag="NGM33_10520"
     CDS             complement(6280..7752)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019609606.1"
                     /locus_tag="NGM33_RS10520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NGM33_10520"
                     /product="MFS transporter"
                     /protein_id="WP_253794529.1"
                     /transl_table=11
                     /translation="MATLVAVALSSVMLPLAVTAPAVALTQLAADLNASVGEAQWVQNA
                     YNVTFAAFMLAAGGLADRFGRRRVLVIGLVVFTAMATVIGLSSNILVIDVARAVQGIGA
                     AGIMTSGSAILADSFRGAARARAFGLLGTSFGFGLAMGPFVAGLMVNFLDWRMVFLMNI
                     AFAAVVLLLVRSIRESSDPGSTSVDWGGVMTFSTSLFLLSLAFVQGAEAGWLSLSAIGS
                     AVGFLVFLAAFIVVESQVRRPMFDLSLFKRPTFVVVVCQPFTITFGFVVLLVYLPPFFQ
                     GVGGFGAAEAGALLLPLTLPVLALPMLAGQLAARLPLRVMLATSSLLIAGGSLWLMTLQ
                     PGQHWTALAAPLALFGTGVGSAFGVMDNAALSSVEVERAGMASGIFNTMRITGESVAIA
                     GAGSLLATLSLNTLDLPFADPEQERTLAGEATQGRLETALGQFAEADRSTALDAVSASL
                     TSAMHTTFLGLALLALVGAVVTFLVVRERELR"
     gene            7973..9634
                     /locus_tag="NGM33_RS10525"
                     /old_locus_tag="NGM33_10525"
     CDS             7973..9634
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013154384.1"
                     /locus_tag="NGM33_RS10525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NGM33_10525"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_130394753.1"
                     /transl_table=11
                     /translation="MPLTSDDTASTRAHSAPSDVLVVGAGPVGLTAACELLRRGVRVRL
                     IDRAESASPFPKALLLWPRTLDLLDDLGALESTRRAGIDIRRFRYYSSGDPLATFTFPE
                     HLAPVCLPQNETERVLTERLHALGGRVERGVRLLALDGLDFSGDITATEGVTAILEHSD
                     GTVERYHAPFLIGADGAGSAVRAQIGTGFVGSTYESAFALVDCRIEGELPVDEALYYQS
                     PRGALVIVALPDGVFRFFASLPPGEKAGVDLLQRITDEQGPGGVRLVDPVWESVFRVHR
                     RHADDFQRGRVFLAGDAAHVHSPAGGQGLNTGMQDAQNLAWKLAAVTQGEAGPRLLSTY
                     GPERKDVARQVVRDTDIQTRGWMLQHPVQTAGRDAAFRILEPVMERGYLPVMAGYRFRY
                     TPARLTQEPAWPSLCRVTGRLAGAVRTGHALPRSLAVDLGLAGHGEAGSGPGARGWTLA
                     VTPGRGRTRDGEPFSALVADRPQVRTVALSADQASEHRLCSAPGYHLVRPDGYVAAHGH
                     MRDHARLRVELAVHLGTADGRRHAPGAAGQAAPSRA"
     misc_feature    complement(9803..9812)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(10038..10055)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.91"
                     /tool="antismash"
     misc_feature    complement(10123..10138)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.26"
                     /tool="antismash"
     misc_feature    10126..10141
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.7"
                     /tool="antismash"
     misc_feature    10386..10400
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.2"
                     /tool="antismash"
ORIGIN
        1 ggccgacctc cccacactcg acagggacga actgggccgg gcgatcgaca ccctggtgcg
       61 caccgacccg tccgccctga cccgcgcctc cctgaacgtc atggggggca cccggtcgac
      121 catgcgcctg ggggcggtcc cggcggacct gtacctggac gagatcgcgc cgcacgtgcg
      181 ccccttcgaa cagggcgacc tgttcaccac cctcggcacc ccgttccaca tgcgggcctg
      241 ccaggagctg cacaacggac tcgccgccag ggccggggtg cccacactct ccatggacgc
      301 gccgaccgac cagatgatcg acgcctacct ggacctgttc gagcgccacg gggtcaacgc
      361 cctgggcacc accctcgaca ccttccggag cctgctccgt tactgcgccg cgtccggccg
      421 ggacctcggg ttcctgcgca aggtgctgtg gagcggtccg gccatggacg ccgccacccg
      481 ggcgctgatc cggacacact ttccccacct gcgcacatgg gcgctcttcg gctcggcgga
      541 gacctggatc atcgggcaca gcggcccgga ctgcgccaac gacaccctcc acccgctccc
      601 ccaccagtac acggagatcg tcgacgggcg catgctggtg accgtcacgc acgagaaggc
      661 ggtcgtcccg ctgctgcgct acgagaccgg ggtcgcggcc gaatggacgg cctgcccctg
      721 cggcctgccc ggtcccgcgg tgcgcaccca caaccgcata gacgccccga tggggccgct
      781 cagccgggtg gtctcccccc tcgacctcgt gccgctggcc ctgcggctcg actcggtgga
      841 ggcggcccag gtcgtcctgg tcgatcccca caccgaggac gaacggctcc acctgcgggt
      901 ccggctgcgc ccggagacca ggtccgagct ctacaccggc gagtggatcc ggcagcacgt
      961 gctgtccgag tcgctggggc tgtccgaggt gacggaggag gctccggagt ccttcgaggt
     1021 catcgtctcc cggcacatgc tgcgggaact cccggacggg tcggcccccg aattcctggt
     1081 gcgcgagggg ggacgcctcc gaacccatcc gatatcgagt cagggtcagg gttcttatgg
     1141 taccttctcg gcataggttc aggagggcgg gtcgcacgcg ccgtatgcgg cgcccaggtc
     1201 acacccccgg gtagcaacct ccctgagtcg cgtcgagcac gaccaccgag cacaggagtg
     1261 cgcatgcgga ctgttccgct gaccaccgac ggccccaccg tgtccgccca ggggctgggc
     1321 tgcatgggga tgagcgagtt ctacggcccg ggagacgagg ccgactccct cgcgaccctg
     1381 caccacgccc tggacctggg cgtcggcttc ctcgacaccg cggacatgta cgggcacggg
     1441 gccaacgagg agttggtggg caaggtcgtc cgggaacggc gggaggaggt cgtcctcgcc
     1501 accaagttcg ggatcgtccg cgaccgcggg acgggtgccc gcagccaccg cggggacgcg
     1561 gagtacgtcc acacggcctg cgacgccagc ctctcccgcc tgggcgtcga gacgatcgac
     1621 ctctactaca tgcaccggcg cgacacctcg gtccccgtcg aggagacggt cggggccatg
     1681 gccgagctgg tcgcccaggg caaggtgcgc cacctggggc tgtccgaggt gagcgccgac
     1741 gagctgcgcg ccgcccacgc cgtgcacccg atcgccgccg tgcagacgga gtggtcgctg
     1801 tggagccgcg acgtagagga ttccgtggtg ggcgagtgcg cgcggctcgg cgtgggcttc
     1861 gtcccctact ccccgctggg acgcggcttc ctcaccgggg ccctccctcc ggtggaggag
     1921 ttgtccgccg acgacttccg ccgcggcaag ccgcgcttct ccggcgagaa cgccgtgcgc
     1981 aaccaggatc tgctcgccat cgtgcggcgg gtggccgtgg cccacggcgc gaccccgggc
     2041 caggtcgccc tggcgtgggt ccacgcccaa gccgagcgct ggggcctgcc cgtcgtcccc
     2101 atcccgggaa ccaagaggcg cgaacgcctg gaggagaacg tgggcggcgc ggacctggtc
     2161 ctctccccgg aggacctcgc cgaactcgac accatcgccg acgccaccgc gggcgcgcgg
     2221 tactgaccct cccccgagcc ggggtggagc ggacggctcc cggcgccggc ctgacgaccg
     2281 gccgacgagc acggagggac aggcgctctg agatacgatt cccagatgac ccagcttccc
     2341 atggaccagc ggatcggtca tcacctgaag cgcgccgagc aggagctgat ctccgcgaag
     2401 cacgctgttc tgaggcagtt caacctctcg gtcccccagt acacggtcct gctcgtgctc
     2461 tcggaggagc ccggggcctc aggtgcgatc ctggcccgca ggtgcctggt gaccccccag
     2521 acgatgtcct cggtcctcgc gaccctgagc aggcgcgaac tgatcgagcg caagccccac
     2581 cctctgcact cccacatcct ggagacgagg ctctccccca gcggacagga cctgctcgcc
     2641 aaggcggacg aggccgcgat ccgggtggag atgcggctga gcgaggcgtt cagcagcgag
     2701 gaggagggtg agttcgtccg cttcctcagc cggtgcgcgg aggtctccgc ggagacccgc
     2761 accgaactgg ctgacctggg cgaggagtga ccccggtccg ggcgggcgcc ccggcgtcac
     2821 cgcgcgggga gccggacggg gccccgcccc gccgctccgt gggcgcccgc ctcccgcgcc
     2881 ttcccggaga ggcgctcgcg ggggcgctcc ccgaggcgtt ctgaaaggca cccggacagg
     2941 cgtcccggga aaggcgtccg gaagtggccg cgcccccacg gtcgggacac cgaccgctca
     3001 cgcacgtccc gggatggagc gtgcacggcc ccggggaccg aacacgcccc gcccgccccc
     3061 cggcccggga ggggtcacgc gggagcgtgg accggagccg cccccgcgga gcggatcgaa
     3121 cggaccacgg aggccgccct cgcggccacg ggactccacc gcacgagggc cagcccgacg
     3181 ctcatgccgc cgccgaaccc cgcgagcagg acgaggtcgt cccgttcgag cagcccggcg
     3241 cggtgcaccg tgtccagggc gacgggcacc gatcccgaac ccgtgttgcc atgggtctgc
     3301 acggtcaggt ggaggtgggc gttgtccagg cccagcgacg gccagacgtc ctcgagcatg
     3361 gcgccgttgg cctggtgggg cacgaagtgg cggatctcct cccggtccac gcccaggccg
     3421 tcgagcatcc ggtggaccgc ctcgggcagc cgccgggtga cgtactcgcg cacgccgcgg
     3481 ccctccatcg tgaagaagtg cccgccctgt cccagggtct ccgcggaggc gggcaggcgc
     3541 gagcccccgg ccggaaccct gatcaggtgg tggtggtccc cgtcggtgag cagctgcgtc
     3601 cccatgacgc cgccgcggtc gtgcgcgggc cccagcagga ccgcgcccgc gccgtcgccg
     3661 aacaggaccg ccgtcctgcg gtcgccgtag tcgaggatcc gggagtagat gtccgcgccg
     3721 atgaccagcg cgtaggcctc cccgtgcggc cgcagcaagt gctcggccac ggagagggcg
     3781 tagacgaacc cgctgcacac ggcgttgacg tcgaacgccg ccgcggaccg cgcgccgagc
     3841 aggtgctggg tgatgctggc cgtcgcgggc tgggggtggt ccggggtgga cgtggcgacg
     3901 atgacgtagg ccaagcggtc cgcggacaca cccgcctgcg ccagtgcccg tcggccggcc
     3961 gccgcggcga ggtcggaggt ggcctgctcg ggggcggcgc gtcggcgctc gcggatcccc
     4021 gtcttgcggc ggatccactc gtctgtgaca ccggcggtgc gggcgatcgg ctcgttgccg
     4081 accacttcgt ccggcaggta cgagcccgta ccgaggatgg cgatggtcat cgtgctgtct
     4141 ccttcttgct ggactgcggg gagggaaggg cccgggagcg ccgccgcacc gcgcggaggc
     4201 gctcccgacc cggcgtcacg cgttcaccga cgggagggtc ggggctccct ccgcagcgcc
     4261 ggggcccggg cggtcggagc ggacgcgttc ccatccgttg gcctcggcgt gcgcggtgag
     4321 cgtcgcgtcc tcgccgacgg cgaccgggac tcccacggcc gacagcaggg cgaggtcgct
     4381 ggagtggtct ccgtaggcgg tgcacgagga caggggtacg cctctcaccg ccgcggcggc
     4441 cctggcggcg gtctccttcg tcgcgccgat catcgggacg aggacctcac cggtcaggcg
     4501 cccggcgcgg acgaccggcc gtgtgcccag tgcccagtgg gctccggcct cctccgcgat
     4561 cgggtccagg caggcgaaga aggagcccga gagcaggacg accaggtcgc cctcggcccg
     4621 gtggcggcgc aggcgctcca gcaccggcgt gtgccagaag cccggcacgc gcccggcctc
     4681 ggagaaccac gcccggccct cggcgcgcag cccctcgacg gactcgcccg ccatgatgcg
     4741 gtagtagagg cggttgacgt cctggcgggg cacgccccgg gccgccgccg ccctgaggcg
     4801 ggccacggct cgttcgtagg agccgggcgg cctggagccg ttcccgaggt ggaactccag
     4861 gaacgagaac atgctcttcg gtccgatgag cgtctcgtcc acgtcgaaga acgcgatgcc
     4921 gcgcccccgg gtccccgggg tgtgcgctcc gttcgcaagg gtcatggctt ctcctgtcgt
     4981 aggggtcggc acggtccgct tcacgcgggg aggcggacca gaccgacctc gatccggcag
     5041 atcgacgcgc ccctctggag cacgtccacc tcgacggagg tcggggcggg ttccgggccg
     5101 ccggtgggcg cgaggaactc cacgattccg ccctgcgtgt agtagacgcc ttcctctccg
     5161 gtcccctccg cttccgccgg agcggtgacg gcccgcatct cggtccgggg ctccagttcg
     5221 ccgaagctgg tgaaggtggc ggtgatctcg gtggggtagg ccttggccgg cgaggtgccc
     5281 cggacctcca ggagcgtgtt cagggccagt tggcgcccgg cctcgatcag gaccatgccc
     5341 ggcagatggt cttgggcgtg gtcgaacagg ctcgggtgct ggggcagcac gcgcagggag
     5401 gccgacacgg tgtccccggc ccccgcgagc ccggtcagga ccacgttgtc gccgttcgac
     5461 cggccgacga ggtagggagc ggggacctcc ccgctgacgg tgaagtcgaa ggtctccgtg
     5521 gaggggaccg gctcaccgga gcggttgccc aggcgcagcg cctcgtagct cgccggggac
     5581 ttgaaccgca gcccgacgac ggcgttgccg acctccgtgc cgccgacgaa gagtcggaac
     5641 ctggcgtcgt agccgacgac gcgtccttcc ttgaccctct tgtccccgac ggagcagagc
     5701 atgcggaggg cgcacggagc cgtccccacc gtcatcagct cggggcgcgt gatggtgatg
     5761 cccaaggtgg tgagcacgaa cttgtggtcg aaggggacgc cgtagtgggt gtgcgcgatg
     5821 gccagcccca cctgtcggca tgcttcgagc agcagcacgg ggtcgtggcg gcgggggcgg
     5881 agcaggtggt cgccgtaata ggcgtgcgaa cgggggagct gggcggcggc cgcgtgggcg
     5941 tcaccgccga ggggctgggt gtcggtgacg aagacctccg ccaacgactc ccggtggacg
     6001 acggtgcggt caacggtccg ctcgtagtcc agggccggac cctccgggcc tgcggtcacg
     6061 gtgtcggtgg cgccgttgag gaggtggtgc acgggcatct gcatggtatg tctcacattc
     6121 ctcgggcttg tggtcctgat gtgggggccg cgggcggaga gcgtctcccg cggtgcgtcg
     6181 gtacggcggg tcggaggccg gggtccgggg tccgggagag gggcgttcgg tggtggacgg
     6241 tggacgggag cccgagcgga gggcccgcga ggacaccgcc tagcggagct cgcgttccct
     6301 gacgacgagg aacgtgacca ccgcgccgac cagggcgagg agcgccagac ccaggaacgt
     6361 ggtgtgcatc gcggaggtga ggctggccga gacggcgtcc agcgcggtcg agcggtccgc
     6421 ctcggcgaac tggcccagcg ccgtttccag tcggccctgg gtggcctcgc ccgccagggt
     6481 ccgctcctgt tcggggtcgg cgaaggggag gtcgagcgtg ttcagggaca gggtcgccaa
     6541 caaggacccg gctccggcga tcgccacgct ctccccggtg atgcgcatgg tgttgaagat
     6601 gcccgaggcc atcccggccc gctcgacctc cacggagctg agcgccgcgt tgtccatgac
     6661 gccgaaggcg cttcccaccc ccgtgccgaa cagggccagg ggagcggcga gcgccgtcca
     6721 gtgctggccc ggctggaggg tcatcaacca cagggatccg cccgcgatga gcagggagct
     6781 ggtggcgagc atgacccgca gggggagcct tgcggcgagc tgcccggcca gcatcggcag
     6841 ggcgagcacc ggcagggtca ggggcaggag cagggccccg gcctcggcgg cgccgaaccc
     6901 gccgacgccc tggaagaagg gcggcaggta gacgagcagg accacgaagc cgaaggtgat
     6961 ggtgaagggc tggcagacga ccacgacgaa cgtgggccgc ttgaacagcg agaggtcgaa
     7021 catcgggcgc cggacctgcg actccaccac gatgaaggcc gcgaggaaga cgaggaaccc
     7081 gaccgccgac ccgatcgcgc tcaggctgag ccaacccgcc tcggcgccct ggacgaaggc
     7141 gagggagagc aggaacaggc tggtgctgaa ggtcatgact ccgccccagt ccaccgaggt
     7201 ggaaccgggg tcgctcgact cccggatcga gcggaccagg agcaggacga cggcggcgaa
     7261 cgcgatgttc atcaggaaca ccatgcgcca gtccaggaag ttgaccatca gcccggcgac
     7321 gaagggcccc atggccagcc cgaagccgaa ggaggttccc aggaggccga aggcccgggc
     7381 ccgggccgct ccccggaagg agtcggcgag gatcgccgat ccgctggtca tgatgcccgc
     7441 ggcgccgatg ccctggaccg cgcgggcgac gtcgatgacg aggatgttgg aggagagacc
     7501 gatcaccgtg gccatcgccg tgaagacgac gaggccgatg acgaggaccc ggcgcctgcc
     7561 gaagcggtcg gcgagtccgc cggcggcgag catgaacgcc gcgaaagtga cgttgtaggc
     7621 gttctggacc cactgggcct cgccgacgct ggcgttcagg tcggccgcga gctgggtgag
     7681 cgccacggcc ggagcggtga cggcgagcgg cagcatcacg ctggacagag cgacggcgac
     7741 gagtgtggcc accgcctgtc ccctggtcaa cggggcggga gcactccgtg cgccctgccg
     7801 atccgttgct tctatcgcca ttcccctacc ccttaattcg cttccttata gtcatccatt
     7861 cacggatgag cataaggtgt cttatgtcca tcgtcaatct tatagaactg gccgtacgcg
     7921 gtgggccgac ccgggacacc cgccgcaacc cgttcgatcg gagctccccg aaatgccgtt
     7981 gaccagcgac gacaccgctt ccacccgcgc acacagcgcc ccctccgacg tcctcgtggt
     8041 cggtgccggg cccgtgggcc tgaccgccgc gtgcgagctc ctgagacgag gagtacgtgt
     8101 acggctcatc gaccgcgccg agtccgcctc ccccttcccc aaggccctgc tgctctggcc
     8161 gcgcaccctc gacctgctgg acgacctggg cgccctggaa tccacccggc gggcgggtat
     8221 cgacatccgc aggttccgct actactcctc cggcgacccg ctggccacgt tcacgttccc
     8281 cgagcacctg gctccggtgt gcctgcccca gaacgagacc gagcgcgtgc tcaccgagcg
     8341 gctgcacgcg ctcggcgggc gcgtcgaacg gggggtgcgg ctgctcgccc tcgacgggct
     8401 ggacttctcc ggcgacatca ccgcgaccga gggggtgacc gcgatcctcg aacactccga
     8461 cgggaccgtc gagcgctacc acgcgccctt cctcatcggc gcggacggcg cgggcagcgc
     8521 ggtgcgcgcc cagatcggca ccggcttcgt cggcagcacc tacgagtcgg cgttcgccct
     8581 cgtggactgc cgcatcgagg gggagctgcc cgtcgacgag gcgctctact accagtcgcc
     8641 ccggggcgcc ctggtgatcg tcgccctgcc cgacggcgtc ttccggttct tcgccagcct
     8701 cccgcccggg gagaaagcgg gggtggacct gctccagcgg atcacggacg agcagggccc
     8761 gggaggggtc cggctggtcg acccggtgtg ggagtccgtg ttccgcgtgc accggcggca
     8821 cgccgacgac ttccagcggg gccgcgtctt cctcgccggg gacgcggcgc acgtgcacag
     8881 cccggccggg ggccagggcc tcaacaccgg gatgcaggac gcgcagaacc tggcctggaa
     8941 gctggccgcg gtgacacagg gcgaggccgg gccgcgactg ctctccacct acggccccga
     9001 acgcaaggac gtggcgcgcc aggtcgtgcg cgacaccgac atccaaacac gcgggtggat
     9061 gctccagcac cccgtgcaga cggcgggccg ggacgcggcc ttccgaatcc tggaaccggt
     9121 catggaacgc ggatacctgc ccgtcatggc gggttaccgg ttccgctaca cacccgctcg
     9181 cctcacccag gaacccgcct ggccctccct gtgccgggtg accggacggc tggcgggcgc
     9241 cgtccgcacc ggccacgccc tcccccgttc cctcgcggtg gacctgggcc tcgccgggca
     9301 cggggaggcc gggagcgggc cgggggcccg cgggtggacg ctcgccgtca cacccggccg
     9361 cggacgcacc cgcgacgggg agccgttctc cgcgctcgtc gccgaccggc cccaggtgcg
     9421 gacggtggcg ctgagcgccg accaggcctc ggagcaccgg ctgtgctcgg caccgggcta
     9481 ccacctggtc cggccggacg gctacgtcgc cgcccacggg cacatgcggg accacgcccg
     9541 cctgagggtg gaactggccg tgcacctggg gacggcggac ggtcggcgac atgcgcccgg
     9601 ggccgccggg caggccgcgc cgagccgcgc ctgagagcct cctccacgcg gcgcccggcg
     9661 gcggcgacgg cgctcggcgc cgccggtggg ccccggcgcg gaccggggcc caccggcggg
     9721 gccgccgaac cggcacggtc acaccgggcc ctctccccgc gcacgccggg tcgtgccccg
     9781 gcgcctcccg cggcgccggg gcggccgcct tcaccccgcg cagcggccag gagcggtgag
     9841 caaggtcact cgaccgcatc cggccaccgg gggaacacgc tccgagacat cccccaacaa
     9901 gtgcacatga cctgcggtga tcacgcgctc accagcaggg gaaatcttca ccatgttcct
     9961 cggtgaggga atctgcttta ctgtccaatg gcctcgaccc tgccatgccg acaacgaagg
    10021 catttccccg agaagaatta acgggaattc tacattcatt aacgtcaccg cagccgcccc
    10081 ggcgggatga acgaaatccc tgacacccag agatgcgagc acgagaatga cgatgaatat
    10141 cggaggaaaa gtggaggggc cgctctccct ggcccacgcg ttacagcgcc tggcgaggat
    10201 cccgtccatg cggcgcaagt acggccgtta cctcgtgctg gggcgcaggc cccgcctggc
    10261 ggacctgcct cccctcaccc gtgaggagct cggcgaggcc gtcgacacga tgatgcggga
    10321 gtccccggac gaactctccc gggcctcgct ccacctcacg ggaggaacaa cgtccacgag
    10381 ccggttgggc gcgctcccct ccgacctcca cgtggacgag atcgccccgc accttcagcc
    10441 cttcgcgccg ggcgacctgg tcgcgagcct gagcactccg ttccacatgc gcgcggcgca
    10501 cgacctgcac aacgcgctcg ccgcacgggc cggcgtcccc accctgtcgc tcgacgcccc
    10561 gacggaccag atgatcgagc cgtgcctcga cctcttcgag cggcacgggg tgagcgccct
    10621 cgccgccacc ctggacaccg tccagcgcgt cctgcgcttc tgcgccgcgt ccgggcggcg
    10681 cctggacttc ctgcgcaagg tgctctggag tggaccggcg atggacgcgg ggacgcgctc
    10741 gctgatccgc acgcacttcc cccacctgcg cacatgggcg ctgttcggct ccgcggagac
    10801 ctggatcatc gggcacagcg ggcccgactg cgcgatcgac accttccacc cgctccccta
    10861 ccagcacacc gaggtcgtca acggacgcat gctcgtgacc gtcacgcaca ggaaggcggt
    10921 cgtccccctg ttgcgctacg acaccggcac cggggccgag tgggcgtcgt gcacctgcga
    10981 gctgcccggc cggcccctgc ggaccaacag ccgcatagac gcgccctacg gtccgctcag
    11041 cagtctggtg tcccccgccg acctggcgtc gctcgccctc caactcgact cggtggaagc
    11101 cgcc
//
