GCF_024181065.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP050861.1 (Tenacibaculum mesophilum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-i	1,360,342	1,388,858
Region 2	RiPP-like	2,063,148	2,075,328
Region 3	NI-siderophore	2,281,907	2,314,727	High	bisucaberin B	other:other
Region 4	arylpolyene	2,450,595	2,491,758
Region 5	terpene-precursor	2,540,589	2,561,560
Region 6	terpene	2,600,834	2,623,269	Low	carotenoid	terpene

NZ_CP050861.1 - Region 1 - lanthipeptide-class-i

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Location: 1,360,342 - 1,388,858 nt. (total: 28,517 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

HER15_RS06200: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

HER15_RS06210: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

HER15_RS06220: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0001392.5	0.48	ribosomal	pinensins	Chitinophaga pinensis DSM 2588
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000504.5	0.46	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000500.5	0.45	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000519.4	0.44	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000527.5	0.43	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001634.3	0.42	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0001392.5	0.48	ribosomal	pinensins	Chitinophaga pinensis DSM 2588
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000504.5	0.46	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000500.5	0.45	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000519.4	0.44	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000527.5	0.43	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001634.3	0.42	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for HER15_RS06210

HER15_RS06230

Leader:

MKKITLNKGLKLNKEAITK

Core:

LQDSQMSSFKGGVREAEGLTCANGSCIKSCNRNSCKDQVIN

Core with dehydrations:

LQDDhaQMDhaDhaFKGGVREAEGLDhbCysANGDhaCysIKDhaCysNRNDhaCysKDQVIN

antiSMASH-DB 4.0 matches for HER15_RS06230

100.0%

NZ_CP032544.1and 2 others:

NZ_CP050861.1 Lanthipeptides: HER15_RS06230_lanthipeptideNZ_LDOD01000011.1 Lanthipeptides: ACI36_RS12155_lanthipeptide

Lanthipeptides: D6200_RS07485_lanthipeptide

1

LQDSQMSSFKGGVREAEGLTCANGSCIKSCNRNSCKDQVIN

41

LQDSQMSSFKGGVREAEGLTCANGSCIKSCNRNSCKDQVIN

1

LQDSQMSSFKGGVREAEGLTCANGSCIKSCNRNSCKDQVIN

41

34.1%

NZ_CP091285.1:

Lanthipeptides: L2Z92_RS06785_lanthipeptide

6

MSSFKGGV-REAEGLTCANGSCIKSCNRNSCKDQVI

40

MS KGGV R + ++C +C SCN +C V+

1

MSKLKGGVNRINDSISCLQLTCNTSCNNGTCNGAVL

36

29.3%

NZ_QLMA01000008.1:

Lanthipeptides: CLV59_RS22430_lanthipeptide

11

GGVREAEGLTCANGSC-----IKSCNRNSC

35

GG+ +A+ +C GSC SC++NSC

3

GGLVDAD-TSCGEGSCQSQQGASSCDKNSC

31

with 3 more sequence matches

19.5%

NZ_CP086141.1and 3 others:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptideNZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptideNZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

4

SQMSSFKGGVREAEGLTCANGSCIKSCNR

32

S +S+ L +C KSCN+

6

SAISATVASATAVSALFTVTSACTKSCNK

34

17.1%

NZ_JARFNJ010000017.1:

Lassopeptides: PX554_RS23695_lassopeptide

9

FKGGVREAEGLT

20

F GG+R+ GLT

9

FVGGLRQTIGLT

20

14.6%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

21

CANGSCIKSCNR

32

C +C KSCN+

26

CPTSACSKSCNK

37

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

Additional weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.30 out of 26.85

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

HER15_RS06230 - Class I

Cleavage pHMM score: -11.80

RODEO score: 14

Monoisotopic mass: 4251.0 Da

Molecular weight: 4253.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4271.7 Da N = 1; 4289.8 Da N = 2; 4307.8 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 141 - 231; Score: 61.4

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_CP050861.1 - Region 2 - RiPP-like

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Location: 2,063,148 - 2,075,328 nt. (total: 12,181 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

HER15_RS09305: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002005.2	0.46	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0002334.3	0.45	other (other), ribosomal	heptyltyrazolone, nonyltyrazolone, undecyltyrazolone, (Z)-ω-6-undecenyltyrazolone	Pseudoalteromonas rubra
BGC0000617.5	0.43	ribosomal	coagulin	Bacillus coagulans
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0002640.2	0.43	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000587.5	0.42	ribosomal	microcin H47	Escherichia coli
BGC0002579.2	0.42	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002382.3	0.41	ribosomal	grimoviridin	Grimontia marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002005.2	0.46	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0002334.3	0.45	other (other), ribosomal	heptyltyrazolone, nonyltyrazolone, undecyltyrazolone, (Z)-ω-6-undecenyltyrazolone	Pseudoalteromonas rubra
BGC0000617.5	0.43	ribosomal	coagulin	Bacillus coagulans
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0002640.2	0.43	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000587.5	0.42	ribosomal	microcin H47	Escherichia coli
BGC0002579.2	0.42	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002382.3	0.41	ribosomal	grimoviridin	Grimontia marina

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.39 out of 26.06

Confidence: medium

Additional weak hits (1):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.12 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_CP050861.1 - Region 3 - NI-siderophore

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Location: 2,281,907 - 2,314,727 nt. (total: 32,821 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase reductase

HER15_RS10310: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

HER15_RS10330: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Hydrolases: dehalogenase hydrolase

HER15_RS10265: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

HER15_RS10365: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: decarboxylase hydratase

HER15_RS10325: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

HER15_RS10375: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001531.5	0.97	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000941.3	0.70	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3	0.69	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002620.2	0.69	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0001478.5	0.66	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002469.2	0.62	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002305.2	0.62	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001453.5	0.61	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0000940.5	0.61	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001531.5	0.97	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000941.3	0.70	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3	0.69	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002620.2	0.69	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0001478.5	0.66	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002469.2	0.62	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002305.2	0.62	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001453.5	0.61	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0000940.5	0.61	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.05 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.22 out of 18.16

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93

Confidence: medium

Additional weak hits (4):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.25 out of 30.97

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.52 out of 30.12

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.63 out of 23.43

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
LexA variant 3	Repressor of DNA damage response

NZ_CP050861.1 - Region 4 - arylpolyene

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Location: 2,450,595 - 2,491,758 nt. (total: 41,164 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

HER15_RS11085: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Ligases: synthase

HER15_RS11005: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

HER15_RS11075: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HER15_RS11105: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.58	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0001238.3	0.58	other (other)	biotin	Aspergillus nidulans
BGC0001239.3	0.58	other (other)	biotin	Aspergillus nidulans
BGC0000857.3	0.46	other (other)	ectoine	Methylophaga alcalica
BGC0001400.3	0.41	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0000905.5	0.38	other (other)	heme D1	Heliobacillus mobilis
BGC0002675.2	0.37	PKS	prodigiosin	Pseudoalteromonas rubra
BGC0001151.5	0.34	other (non-nrp beta-lactam)	valclavam, (-)-2-(2-hydroxyethyl)clavam	Streptomyces antibioticus
BGC0000260.3	0.33	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0000174.5	0.32	PKS	bryostatin	Candidatus Endobugula sertula

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.58	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0001238.3	0.58	other (other)	biotin	Aspergillus nidulans
BGC0001239.3	0.58	other (other)	biotin	Aspergillus nidulans
BGC0000857.3	0.46	other (other)	ectoine	Methylophaga alcalica
BGC0001400.3	0.41	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0000905.5	0.38	other (other)	heme D1	Heliobacillus mobilis
BGC0002675.2	0.37	PKS	prodigiosin	Pseudoalteromonas rubra
BGC0001151.5	0.34	other (non-nrp beta-lactam)	valclavam, (-)-2-(2-hydroxyethyl)clavam	Streptomyces antibioticus
BGC0000260.3	0.33	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0000174.5	0.32	PKS	bryostatin	Candidatus Endobugula sertula

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.76 out of 29.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 26.06 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.56 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.39 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.40 out of 21.55

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.54 out of 27.04

Confidence: medium

Additional weak hits (2):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.09 out of 39.62

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.28 out of 30.98

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
DasR	N-acetylglucosamine dependent repressor
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis

NZ_CP050861.1 - Region 5 - terpene-precursor

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Location: 2,540,589 - 2,561,560 nt. (total: 20,972 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

HER15_RS11535: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

HER15_RS11500: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.38	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000643.3	0.35	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.35	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000678.5	0.34	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001733.3	0.33	ribosomal	PcpA	Pleurocapsa sp. PCC 7327
BGC0000664.5	0.32	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001395.5	0.32	other (other)	teichomycin A1	Actinoplanes teichomyceticus
BGC0000665.5	0.31	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001227.3	0.31	terpene	isorenieratene	Streptomyces collinus Tu 365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.38	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000643.3	0.35	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.35	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000678.5	0.34	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001733.3	0.33	ribosomal	PcpA	Pleurocapsa sp. PCC 7327
BGC0000664.5	0.32	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001395.5	0.32	other (other)	teichomycin A1	Actinoplanes teichomyceticus
BGC0000665.5	0.31	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001227.3	0.31	terpene	isorenieratene	Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

HER15_RS11500: PT_FPPS_like

Domain 1 (26 - 322): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.85 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19

Confidence: medium

Additional weak hits (1):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_CP050861.1 - Region 6 - terpene

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Location: 2,600,834 - 2,623,269 nt. (total: 22,436 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene overview

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HER15_RS11805: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.57	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000637.3	0.46	terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.3	0.41	terpene	carotenoid	Dietzia sp. CQ4
BGC0000636.3	0.40	terpene	carotenoid	Brevibacterium linens
BGC0000633.3	0.39	terpene	carotenoid	Streptomyces avermitilis
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0001227.3	0.38	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0002507.3	0.35	PKS	sporandol	Chrysosporium merdarium
BGC0002709.2	0.31	PKS	aurofusarin	Fusarium graminearum PH-1
BGC0000069.5	0.26	PKS	gephyronic acid	Archangium violaceum Cb vi76

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.57	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000637.3	0.46	terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.3	0.41	terpene	carotenoid	Dietzia sp. CQ4
BGC0000636.3	0.40	terpene	carotenoid	Brevibacterium linens
BGC0000633.3	0.39	terpene	carotenoid	Streptomyces avermitilis
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0001227.3	0.38	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0002507.3	0.35	PKS	sporandol	Chrysosporium merdarium
BGC0002709.2	0.31	PKS	aurofusarin	Fusarium graminearum PH-1
BGC0000069.5	0.26	PKS	gephyronic acid	Archangium violaceum Cb vi76

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

HER15_RS11810: PT_phytoene_like

Domain 1 (9 - 272): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

HER15_RS11825: Lycopene_cycl

Domain 1 (4 - 92): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description