LOCUS       NZ_CP050861            28517 bp    DNA     circular CON 16-JUL-2024
DEFINITION  Tenacibaculum mesophilum strain bac2 chromosome, complete genome.
ACCESSION   NZ_CP050861
VERSION     NZ_CP050861.1
KEYWORDS    RefSeq.
SOURCE      Tenacibaculum mesophilum
  ORGANISM  Tenacibaculum mesophilum
            Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
            Flavobacteriaceae; Tenacibaculum.
REFERENCE   1  (bases 1 to 3360630)
  AUTHORS   Li,M.
  TITLE     Tenacibaculum mesophilum bac2
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3360630)
  AUTHORS   Li,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2020) College of Ocean and Earth Science of Xiamen
            University, Xiamen University, Xiangan South Rd, Xiamen, Fujian
            361102, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 500.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024181065.1-RS_2024_07_16
            Annotation Date                   :: 07/16/2024 03:22:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,062
            CDSs (total)                      :: 2,988
            Genes (coding)                    :: 2,973
            CDSs (with protein)               :: 2,973
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 15
            CDSs (without protein)            :: 15
            Pseudo Genes (ambiguous residues) :: 0 of 15
            Pseudo Genes (frameshifted)       :: 3 of 15
            Pseudo Genes (incomplete)         :: 12 of 15
            Pseudo Genes (internal stop)      :: 4 of 15
            Pseudo Genes (multiple problems)  :: 3 of 15
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:51:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1360341
            Orig. end                         :: 1388858
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050861.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..28517
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..28517
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28517
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:18517](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..18517)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(607..622)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.3"
                     /tool="antismash"
     gene            1156..2568
                     /locus_tag="HER15_RS06165"
                     /old_locus_tag="HER15_06165"
     CDS             1156..2568
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024091.4"
                     /locus_tag="HER15_RS06165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06165"
                     /product="DUF3526 domain-containing protein"
                     /protein_id="WP_253680802.1"
                     /transl_table=11
                     /translation="MFFQTINYELKILFRNGWITLLTVILLSIIGFATYNGQKKVKQRT
                     DDIIKVKQNLVESDTKMLKNILDIENGIDTGLPYWMLPNNPSTVGTRHPRVVAMDAQPL
                     SFIATGQSDLYTHFMKPSIFGNNFALDYTEIANPVQLLFGTFDISFVFIFILPLLIIAF
                     TYNILSREKELGTLRLIGSQPLTIRKWLIQKLGFRFILFASISLVVFLVCILIFTKNAL
                     LNFSQLFATIMLLIAYEAFWFSLAGIVNLKINNSSKNALSLIGLWLLIVLVIPATANQI
                     STSIYPTPSRLNMINEIREANREIEKKQDEILDGYLRDHPELANKENKNFTFWHRYFAS
                     QDLLEQQLSPLLLNYNKALKKQQQVVDYFKYTSPAILMQEALNKIAGTSANDYENYKQQ
                     VVSFSNKWRDHIVPLLFKNKKYTIETYQSRPTFIFKPLEQKTTKNLIAILMLTSVVILT
                     GFLIKKKTSYFS"
     gene            complement(2692..3939)
                     /locus_tag="HER15_RS06170"
                     /old_locus_tag="HER15_06170"
     CDS             complement(2692..3939)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008991684.1"
                     /locus_tag="HER15_RS06170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06170"
                     /product="DUF4374 domain-containing protein"
                     /protein_id="WP_047790180.1"
                     /transl_table=11
                     /translation="MKYKNLYSALFIAAAIFTSCSDDNTPKQGETPQKGAKYLITATPK
                     ASEGVADYILTTDNLTQGKISTVGNGIEQDGTYRYYVTSNNKFFSLLYGQGNPGAVTTY
                     QLDDKGALEKLSNFQSETVQAFAPVKDDLLLIKISRNSDSPIASWYRLDTRTSQFVAEG
                     QINTKDLANKENGELAFFTWITQVGDYVYLPYFTIKGNSTDRFGTNYPNEANIAVYSYP
                     EMEYVKTIHDDRTSHIGRYFNNGLSVDEKGDTYAFSSSVATTNGEITSTKPSAITRIKK
                     GETAFDQAFYYNIEEASGNRYVTSHLYLGNGKFLVNLHDTASKGTYSSGKDLAIVDVYA
                     KTLTDVTGLPTKEEIESIASKGHYVSKAEGIVYIGITTKNGSYVYNIDARTAKATQGIE
                     VEGGTITAINKLDPAN"
     gene            complement(3988..6351)
                     /locus_tag="HER15_RS06175"
                     /old_locus_tag="HER15_06175"
     CDS             complement(3988..6351)
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1082:
                     TonB-dependent siderophore receptor family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006256952.1"
                     /locus_tag="HER15_RS06175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06175"
                     /product="TonB-dependent receptor"
                     /protein_id="WP_239180027.1"
                     /transl_table=11
                     /translation="MNIFKKSISFITINLLFLFVGYTQSKLSGTVVDAWKKTIPGATVI
                     IKDTNKGVSTDINGHFLFKGKLKGKYVLKVSFVGFKTKELFFKIEEGEELVLSIQLEES
                     SVELDEVLVTGKSIVKKVKEKAYNVGVVDAKQLHHTSLDLGHALDRVAGVRIRESGGVG
                     SRMNFSLNGFRGNQVRFFIDGLPMDNFGSSLQINNIPISLAERIEIYKGVVPIGLGADA
                     LGGAVNIITQQHKKSHLEASYSFGSFNTHRSHVNAVYVAKSGFTAQLNAFQNYSDNNYK
                     VNVDVSDLNTGEYFPNQRVKRFNDTYHNEVAIFNVGFVNTEFADQLLFGMTLGQSYREI
                     QTGARMVSVFGAWHTKGNIIMPSVKYKKNDFIFKNLDFKLTANINLGEEKNIDTLHRRY
                     NWFGDFKEYDGPGGERSYSLYKYKNNAGITTTSLNYKLNDKHKITFSNTLNTFDRVGHN
                     ELNPDNEIYEHPKKVMKNVMGLGYDFKSSNWNTSAFIKKYYQRNKFAEAYNPSGNYGDV
                     AYRNQVNKFNHTGYGLAATYFVNDDIQLKASYEKSYRLPEANELYGDVINLEGNLSLKP
                     ESSNNYNLGVSLWKHTSSNHSFNFNANGFYRDAKDFIRPTLNKNQSRQVMDNLASVTNL
                     GVEAEARYNFNNQVSLGANITYQNLRNNTKYEDNQTEVSVVYKDRVPNEPYLFGNADVS
                     YTFSNLWNKEDKLNVVYNLLFVHDFYLYWPSLGSNKLEIPQQISHDISFTYSLNKKLQF
                     TLECRNLLNAELYDNFSLQKPSRNFTGKIKYTFF"
     gene            complement(6481..8052)
                     /locus_tag="HER15_RS06180"
                     /old_locus_tag="HER15_06180"
     CDS             complement(6481..8052)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008612480.1"
                     /locus_tag="HER15_RS06180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06180"
                     /product="PepSY-associated TM helix domain-containing
                     protein"
                     /protein_id="WP_253680804.1"
                     /transl_table=11
                     /translation="MTKRVYNIMFHTHTISGIVISAALYVIFFTGSISFLRDEIIAWER
                     NEPVEKNFFLEGDFDALLNNLGEEYYLKGRDISFYRNIEGQNVITRMGQSKDTLAPKKE
                     PKRAFFYTNLKTFKKANYNQNYSLGEFFYRLHFFAQLNFYGRSGYVFAGLIAFFFLFAI
                     ITGIIVHWKKIVPNFYQFRPKTKWKTIWTDAHVALGVIGLPYQFIFAVTGAYLIIGYMV
                     MLAPVQNYIFNDNSKALTEALNYEKDINYEYKAVELEKTISINDFLVRTKKKYPSLQLN
                     SVEIFNYGDANMHVKVGGYPKYKDNFLSSGSITFKASDGYIVQTKDSKNSLSYIEGATN
                     LLKRLHFGDFGGYGMKLIYLVLGFITCFVIISGVLIWLVARDKKSVPNYKRKFNSWLVN
                     IYMAICLSLYPITALVFISVKCFSNSNGDNRKVFIYQIFFWGWLILSSLFIVKKDNYFT
                     NKISLLLGSILGFLVPISNGAITGNWLWISWQKGYSQIFVVDAFWLLLSITAFSIFFKI
                     KRNKKL"
     gene            complement(8073..8366)
                     /locus_tag="HER15_RS06185"
                     /old_locus_tag="HER15_06185"
     CDS             complement(8073..8366)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008613850.1"
                     /locus_tag="HER15_RS06185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06185"
                     /product="hypothetical protein"
                     /protein_id="WP_073184632.1"
                     /transl_table=11
                     /translation="MPANKKYLTSSPIQRIAKISAGFVGGYVVTETFHIMLMTFLNIPN
                     VIMTLRFFGFIMWAVLMILAFLAKSAWKIWALYTLVSLLFIIVIYLNNPNQL"
     gene            complement(8369..8701)
                     /locus_tag="HER15_RS06190"
                     /old_locus_tag="HER15_06190"
     CDS             complement(8369..8701)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HER15_RS06190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HER15_06190"
                     /product="hypothetical protein"
                     /protein_id="WP_239180025.1"
                     /transl_table=11
                     /translation="MLTIIGCLALIGFYFLYSTSNRADLTFYLPLQKWINENKIKGKYI
                     GVVLLIIGLTSAILYLGFGAGIFSYLTLLMLVSSLVVLIEPLRFLKFSILVVMMILSLL
                     LEVYLK"
     gene            8885..9883
                     /locus_tag="HER15_RS06195"
                     /old_locus_tag="HER15_06195"
     CDS             8885..9883
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="HER15_RS06195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06195"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_253680806.1"
                     /transl_table=11
                     /translation="MKVTIYNNEEAIFDKLSNIKNINDNFYKTLVTNFNENNFKGWYKE
                     HVFENFKIGFGSIKTIKGYKISFNIKGESIEMLFNLKGKFTIHIPEIESKYFFNSNSHN
                     INFYSNTKGFLECESSESFIVRLNLSPLFFIQYLPDDIRFDDFKKIISDKKFGKLNSEN
                     CLINSRMHFLIKEVIASEWDNHFRKIHITSKILDLLLLQLYQFTPSTPKKNTTKLTTTE
                     ANKIERVYEYILNNYTSPLTLSLLCKEIGTNEYALKKGFKTTFGITVFKFIANLRMNKA
                     KELLLKGHTVNEVSEKVSYKNPQHFSTAFKKKFGTSPSKFLSELSFYDIKN"
     gene            complement(10001..11164)
                     /locus_tag="HER15_RS06200"
                     /old_locus_tag="HER15_06200"
     CDS             complement(10001..11164)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="HER15_RS06200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06200"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_253680808.1"
                     /sec_met_domain="LANC_like (E-value: 8.6e-15, bitscore:
                     51.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTNNIILEIEKSINNNYGILTSMGVVNGLAGVSLFYHYKDNKDK
                     CLSFLEKSISGLNEDYKGNDIIADIIEIGILLDFYIKEGVIKKEEVAFYFDNYDSILQE
                     LLIDKLKEDNLNPVTGILKYGNYFINRAKDSGKNYDELFSLILSKIEKLAKKDKKTTGI
                     YWVSTIEREGRYLVELGVKHGVIGIVDFLVELYGLGFEKKRTKKLINEAIKYVVESKLK
                     DKTFLFPFCTNNVKDAVSFSFNLNYGDLGIAYGIHKAVKACNLEVYKEVINQTLKNAAN
                     FKDDENKYLTDANLFYGSLGIASLLKKFRKELEEDFLNDSINYWYTKTKEHKRHDNEWA
                     GFDTTFNKFDINAQLSMSHGIIGVGTALLNFNKDLNFDFLTFLGYKF"
     gene            complement(11167..13368)
                     /locus_tag="HER15_RS06205"
                     /old_locus_tag="HER15_06205"
     CDS             complement(11167..13368)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019973992.1"
                     /locus_tag="HER15_RS06205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06205"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_073184754.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.6e-34, bitscore:
                     114.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIRQYDKMDCGPSCLGMVASHYGKEISLNYLREKCYITKEGVS
                     LLGIDEASKKLGFETFSATLGLQELKDIDNLNYPCILHWNNNHFVVLKEHKRPHLLARK
                     KKWQIADPAHGFVNLNDEKFSKSWLGENGKGVALFLKPQNKFVNTEFKKPEKISLKYFI
                     DFFKSHKKKLVFVFVLMLLGSLINMVFPFLTQYLIDKGIDKKDVNYIEYILFSQLSLYL
                     GVIVIEIFRNWSLLVVGTKISIKIISEFLLKTLDLPLKFFDSKLIGDFQQRIQDNDRIE
                     YFLTSQSITTFFSMITFSVFFGVLAYYNITILLIYTSLTLLSVLWSHYFLKKRKILDYN
                     RFIENSNNQETIYEILNGVTEMKLNSFEEYKCNQWKTVQDRLFNINLKILRLDQIQSSG
                     FTFINHVKNILVSFYTAILVVNGDMTLGVLLSISYIIGMMNSPVDQLINFIRSLQDAKL
                     SLSRLNEVQNEDPEEKESYSELKLSNNGTNTGVKLSNVSFQYEGPRSPFVLNNIDLYIP
                     DGKVTAIVGASGSGKTTLMKLLLRFYNSIGGHISYNDQNILNISPRSLRKHCGVVMQDG
                     FIFSDTIKRNIATSDEEIDYERLREAAKIANIDEYIDSLAQGYDTKIGASGSGLSGGQK
                     QRILIARAVYKNPHYMFFDEATSALDAENEKKIHDNLFNFFKGRTVVIIAHRLSTVKHA
                     DQIVVLKKGKVSEVGSHDELVGKKGDYFSLVKNQLELGS"
     gene            complement(13355..16441)
                     /locus_tag="HER15_RS06210"
                     /old_locus_tag="HER15_06210"
     CDS             complement(13355..16441)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="HER15_RS06210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06210"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_253680810.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4e-101, bitscore:
                     336.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.7e-17,
                     bitscore: 61.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.5e-44, bitscore:
                     148.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNISLLPNKIIRQPLLSLNKYNQIPEKEKELNSFIDSLFFNKEF
                     SEAVYLSSPSLYKEWEKVVKKEKERGKINEAILKYFLRSVSNTVPFGLFTSYTTLSSNS
                     SLDNEKKYKRYSSIDLEYLLNLLNHLNQYPIIIQTVKYRRNNTIYKIGDKYRYIEPKFS
                     KGNISYTLSSIDSDELIDYLVSHENDTMTFEELKNMILNLVDGVEEEEVTAYLLDLINS
                     KIYISSFEATLNEEDLLNQVINFYKENSSKIDTDEELKKIFSSLIKVKEKLIELDKKVF
                     NSIDIYNEIFKDLRKIGVDFKEKFVINSNLKKIPKSINDTENIDIKLNKLMSVLSKVSK
                     KNIKEDSNLTVFKRSFYNRYEDKEVALVEALDNELGIGYLPHLKEEVIFSDLIDDVTMP
                     QVRKVTSERKVETKVHNFWLNLLLRNPEKKEINLAKEDLTIFKEENEAKNGAFSISYSY
                     TKDKIYLKHIGGTTGTNLIGRFSNSDTEVQEIINYVTDFEKSLLKNKIVAEVIHLPNNR
                     AGNILIRKVNRDAEISIISKASGNTKVIDVNDLYISLKRNRIVLRSKKENKEVVPFLSS
                     AQNYHYNSLPIYHFLCDLQSQDRHNDYSINFGGFNIGDLEYCPRLTYGKDVILRKATWL
                     LKKDNNKGIESLKADLIKKSVPRYIYITSGGEDKMIIDIENYNTLNILYQEIEKNKILR
                     VTECIYDMHNNETPESYANEYIGVVKSQKELNIFKNISTTHKIENNNVKRTFIYGDEWV
                     YFKLYTGRITSDQLLIENISRIATKLKESGIIDKWFFIRFTDPDFHLRLRFHLKNEKNY
                     SEMSKIIHNELSHLLEEQKIWKLDLSTYNRELERYYWQNIESSETIFHIDSEYTVNMLK
                     YLKDNGESRRWLFILKSIDDFFNVFDISLVKRHQIINTMFNSFWVEYGKVKTIKKDVNN
                     KFRKYVKDINSILNIPEIEVKNIYKERYLALKEVQLSIEAKENLDDLLWSYIHMHVNRF
                     VQANPRFHELIMYGILERYYNQEIGKRKYNQKQVENEAY"
     aSDomain        complement(15749..16018)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HER15_RS06210_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.60E-19"
                     /identifier="RREFam001.1"
                     /label="HER15_RS06210"
                     /locus_tag="HER15_RS06210"
                     /protein_end="231"
                     /protein_start="141"
                     /score="61.4"
                     /tool="antismash"
                     /translation="YRRNNTIYKIGDKYRYIEPKFSKGNISYTLSSIDSDELIDYLVSH
                     ENDTMTFEELKNMILNLVDGVEEEEVTAYLLDLINSKIYISSFEA"
     gene            complement(16443..17387)
                     /locus_tag="HER15_RS06215"
                     /old_locus_tag="HER15_06215"
     CDS             complement(16443..17387)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="HER15_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06215"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_253680812.1"
                     /transl_table=11
                     /translation="MINDILKIGILEFAASNKQNSMHAIEDIFTYACRADELNFSRFWL
                     TEHHRASAVHPYNNPEILMTLIAGMTENIRIGSAGSLIGYYSPYSLAQNYKLLNNIYNN
                     RIDFGLSKGRPENAHQHNFFNLNNSTFENTMYEKNLQAICELLHEEEKKYNESKIVLPP
                     FKGIAPSLWYLSNSYRKKDLAIKNKLNICRSLMHGLDVFEYDEDLKGLQEYKEEYYQTN
                     GQLPEVAIAIAVTFSKTKEQVEQEEKKYKNKREGLKIIPVNKYTFLEKLEKIQKAYGVN
                     EVIICDTEKDIEAKLENLELIKELTTQQVLKTF"
     gene            complement(17384..18517)
                     /locus_tag="HER15_RS06220"
                     /old_locus_tag="HER15_06220"
     CDS             complement(17384..18517)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="HER15_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06220"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_159495266.1"
                     /sec_met_domain="LANC_like (E-value: 7.1e-24, bitscore:
                     81.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEAHKLIENIDKIKREDLESDSLLNGKLGLVYYYLCLYKVFNKE
                     DHLQRIEKNLESVFTNIEKGVSSLMYDSTLENGLSGLGYVLQLLIEEKIIDEGYNSQLE
                     EINNIVVDQAIELIQNNNYDFVRGPFGILFYLNYVDSKPLVNRVLEALFEKLKEDKNFL
                     FYNEYTYIEGVHIGYAHGLCAIIKVLNDINDERAEYFVRYLLDRLMNIMKKNEYQIIKD
                     KKYYLPRSIHKGDEFEKGLNYRAVLAWSNCDVNFSTLIYSLNEKFKTNELLTIANKIAL
                     ESLEKREEKHTRIWDHRFYFGSSGVLKTYMFLYKKTRNSKYKEASNFWYKKTLNFLTES
                     TIKEHPLNFLNNLPATALSLLEFEREEEFNWSKILLL"
     gene            complement(18604..18795)
                     /locus_tag="HER15_RS06225"
                     /old_locus_tag="HER15_06225"
     CDS             complement(18604..18795)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986050.1"
                     /locus_tag="HER15_RS06225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06225"
                     /product="class I lanthipeptide"
                     /protein_id="WP_047790188.1"
                     /transl_table=11
                     /translation="MKKITLNKGLKLNKEAITKLQEAQMSQLKGGVRDAASISCLNFTC
                     NASCDTGTCNGSADQVLN"
     gene            complement(18859..19041)
                     /locus_tag="HER15_RS06230"
                     /old_locus_tag="HER15_06230"
     CDS             complement(18859..19041)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="HER15_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06230"
                     /product="class I lanthipeptide"
                     /protein_id="WP_047790189.1"
                     /transl_table=11
                     /translation="MKKITLNKGLKLNKEAITKLQDSQMSSFKGGVREAEGLTCANGSC
                     IKSCNRNSCKDQVIN"
     CDS_motif       complement(18985..19041)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKITLNKGLKLNKEAITK"
                     /locus_tag="HER15_RS06230_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18859..18984)
                     /prepeptide="core"
                     /locus_tag="HER15_RS06230_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-11.80"
                     /molecular_weight="4253.7"
                     /monoisotopic_mass="4251.0"
                     /core_sequence="LQDSQMSSFKGGVREAEGLTCANGSCIKSCNRNSCKDQVIN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKITLNKGLKLNKEAITK"
                     /leader_location="[18984:19041](-)"
                     /alternative_weights="4271.7"
                     /alternative_weights="4289.8"
                     /alternative_weights="4307.8"
     gene            complement(19053..19244)
                     /locus_tag="HER15_RS06235"
                     /old_locus_tag="HER15_06235"
     CDS             complement(19053..19244)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="HER15_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06235"
                     /product="class I lanthipeptide"
                     /protein_id="WP_047790190.1"
                     /transl_table=11
                     /translation="MKKITLNKGLKLNKEAITKLQDSQMSSFKGGINAAAGATCANGSC
                     IQSCNKNSCKGGADQVIN"
     gene            complement(19257..19445)
                     /locus_tag="HER15_RS06240"
                     /old_locus_tag="HER15_06240"
     CDS             complement(19257..19445)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="HER15_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06240"
                     /product="class I lanthipeptide"
                     /protein_id="WP_125064394.1"
                     /transl_table=11
                     /translation="MKKITLNKGLKLNKEAITKLQDSQMSSFKGGIRDAEGLTCANGSC
                     IKSCNKNSCKGADQVIN"
     gene            complement(19459..19641)
                     /locus_tag="HER15_RS06245"
                     /old_locus_tag="HER15_06245"
     CDS             complement(19459..19641)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="HER15_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06245"
                     /product="class I lanthipeptide"
                     /protein_id="WP_047790192.1"
                     /transl_table=11
                     /translation="MKKITLNKGLKLNKEAITKLQDSQMSSFKGGVREAEGLTCANGSC
                     IKSCNEDSCNANRIQ"
     gene            complement(19660..19848)
                     /locus_tag="HER15_RS06250"
                     /old_locus_tag="HER15_06250"
     CDS             complement(19660..19848)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="HER15_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06250"
                     /product="class I lanthipeptide"
                     /protein_id="WP_047790193.1"
                     /transl_table=11
                     /translation="MKKITLNKGLRLNKEAITKLQDSQMSSFKGGINAAAGATCANGSC
                     IKSCNEDSCKGADQVIH"
     gene            complement(19860..20048)
                     /locus_tag="HER15_RS06255"
                     /old_locus_tag="HER15_06255"
     CDS             complement(19860..20048)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="HER15_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06255"
                     /product="class I lanthipeptide"
                     /protein_id="WP_047790194.1"
                     /transl_table=11
                     /translation="MKKITLNKGLKLNKEAITKLQDSQMSTFKGGIRAAGLTCANGSCI
                     KSCNENSCNGSADQVIN"
     gene            complement(20151..22526)
                     /locus_tag="HER15_RS06260"
                     /old_locus_tag="HER15_06260"
     CDS             complement(20151..22526)
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1082:
                     TonB-dependent siderophore receptor family"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF026255.4"
                     /locus_tag="HER15_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06260"
                     /product="outer membrane beta-barrel family protein"
                     /protein_id="WP_253680814.1"
                     /transl_table=11
                     /translation="MKKQVLNMILLLMCTNILSQITYNGVVVDTEKQPISLANVILYDS
                     INNKLIDGVTTDDRGEFRLKVKEKTSFFIEISFLGFKTKKINVTTNDLGNIVLEEDTSL
                     LKEVIITSKKQTLVRKNDRLVFNIDKTVAQELGSAVEVLRVTPNIVIRDDQLTMLGKSF
                     VRVMVNSKMLPLTGDDLRGYLASINSSDIVRVEVITVPPSEFEAEGNGGVINIVLKKEK
                     KDFWSAVARMSSTQRTLFSYGRSLALNYKKKNTYLTVNISNGLYLKRNIFRNNNFFSNE
                     TWRGNGPSEYEDEYLNYRLSFTQTLTEKWELGLGYSGTNSDIISSTGNKDLIYDLKDEL
                     KYSLLSDGVSNKDAKSHALNFYNTIKLDSLGKKISLDVDYYKSTSFKEGENKGERREQN
                     TITPTFSNNTSIDYDFENISGKIDVSLPYNSIDIKLGGKVSFSQTNNDFKFYDSFNGTP
                     VLDENQSNVFNYDEHIYAAYVSGTKKISEKFSAKAGLRLESTVTKSYSKSNNQSNENKY
                     TKFFPTLYLTYKLKGEQSLSFNVSRRLNRPRFESLDPFKIVVNPFKTIQGNPFLQPSFI
                     TNTELIFNSKKNELKVYSQKITEGYEQISELDPVSKVVNYTYYNHLDIENYGITDTYIF
                     DKLKWLTSYNTIDIGYSKMSSSIPETIREQEGFNAFVQTQNYIKLNSKKTLSLGVNYYH
                     VFAAKQNVSRHGGYGPLDLSLRLKLLKGDLNLVMYANDVLKTSVTTVTGYYNNVKTTYN
                     NYYDSRSLSFIVRYTFGNKNIRTKRDRSGNRDIQNRAQ"
     gene            complement(22582..23268)
                     /locus_tag="HER15_RS06265"
                     /old_locus_tag="HER15_06265"
     CDS             complement(22582..23268)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HER15_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HER15_06265"
                     /product="hypothetical protein"
                     /protein_id="WP_073184646.1"
                     /transl_table=11
                     /translation="MTFKNKSLEILSSSEMINLAEFIVKENFKHHTKGSLPSNYYSSIQ
                     SIYKEELGFSKNSKVFVSKNDKGEIQGAIRVLRWDYSRKLPIQKIFGINPIEIAGMSPL
                     KTIWHIGRFAIKKEVSDINLFKKLMICAISPICEKENSVAFAECDSKLLRVLRILGIEA
                     TVVGEAVNYLGSETIPVCMTYSGLIGFYRKNKHLIFKSIDDSSVKKSKLPKSVVVDSQL
                     VNYTLV"
     gene            23437..24198
                     /locus_tag="HER15_RS06270"
                     /old_locus_tag="HER15_06270"
     CDS             23437..24198
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014937703.1"
                     /locus_tag="HER15_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06270"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_047790196.1"
                     /transl_table=11
                     /translation="MENNINDFFSMKNTVDNISENELLKTSDYLAPIKAFARTTYKSIY
                     IIDYQKKGFEYVSDNPLFLCGHTSEEVKEMGYAFYFKYVTPPDLDLLLKINTVGFDFFE
                     KLPIEERLFYTISYDFNIKNQEKKTILINQKLTPLFLNNDGKVWKAICIISLSTEQHSG
                     NIKIYKQGDNKMFTYNLEGKYWKTEEKITLTNREKEILQYSARGFKINEIAESIFVSPD
                     TVKFHRKKLFDKLEVANITEAISFATNNRLI"
     gene            complement(24195..24938)
                     /locus_tag="HER15_RS06275"
                     /old_locus_tag="HER15_06275"
     CDS             complement(24195..24938)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004920681.1"
                     /locus_tag="HER15_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06275"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_073184649.1"
                     /sec_met_domain="ThiF (E-value: 3e-30, bitscore: 102.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSRNRIYIKPEEQELIKNYPILLGGSGIGSNIAECALRLGFEKI
                     TIVDGDEVELSNLNRQNYTEDDIKTDKVEALSKRLLSINPKADITVHNCFITKENIHSI
                     IEGHKVAVNALDFTSDIPLMFDKICRDKGVPIIHPYNLGWGALVSVITPDSLSLESIAK
                     EEEKFNEVKMVEYAVSYMKFWGKPQKWIEDVIEEYKKEKEVLPPPQLSVASWLVASICT
                     HLLFNISVGKPVKKFPEFYLSSINS"
     gene            complement(25126..25512)
                     /locus_tag="HER15_RS06280"
                     /old_locus_tag="HER15_06280"
     CDS             complement(25126..25512)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HER15_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HER15_06280"
                     /product="hypothetical protein"
                     /protein_id="WP_047790198.1"
                     /transl_table=11
                     /translation="MTLNNHGSDIDVVHKYNHVELKGWVDQLQYINKEIENLLSLHEYS
                     LVNKTISKEILELFSKRKKVNNELYKTVLSYSNTYVNVAECDDIQCDMAYLEEYDRLRE
                     NYQNNLEAYQKLKDKFFDEVLLKE"
     gene            complement(25523..25942)
                     /locus_tag="HER15_RS06285"
                     /old_locus_tag="HER15_06285"
     CDS             complement(25523..25942)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0032784 - regulation of DNA-templated
                     transcription elongation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015361379.1"
                     /locus_tag="HER15_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06285"
                     /product="GreA/GreB family elongation factor"
                     /protein_id="WP_047790199.1"
                     /transl_table=11
                     /translation="MKHGSLVLEKKEYVYIKSLLNVSAHTEESKVQTSLGKFAEELKTA
                     KILDEEQMFDDVIRLNTVVTIASGDVWEKTIQIVRPTEKDLKTNKVSILTPIGIALFGY
                     ALNDVVHWDLPGGKKEVKILKVVQEKKNESFSTLI"
     gene            complement(25954..27255)
                     /locus_tag="HER15_RS06290"
                     /old_locus_tag="HER15_06290"
     CDS             complement(25954..27255)
                     /EC_number="1.4.1.-"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007651518.1"
                     /locus_tag="HER15_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HER15_06290"
                     /product="Glu/Leu/Phe/Val dehydrogenase"
                     /protein_id="WP_047790200.1"
                     /transl_table=11
                     /translation="MTLTKELKKPVKRKNARGMVDNVLEQFNSASDQIGLHPNIRKILS
                     ITNNEIIVNFPVKMDNGDVEIFQGYRVQHNNALGPYKGGLRYHPTVDIDAARALAMWMT
                     WKTSLAGLPYGGGKGGIQIDPAKYSKDELERITRRFTFALGDNIGPEHDIPAPDVNTNA
                     QTMAWMADTYMSTKAPAERSMNQHVVTGKPIGSGGLEGRDRATGYGVFLTIKFWVEENN
                     QTLEGKTFIVQGFGNVGYWAAYFLEQEGAKMIGVQDAYGSIQNTNGIKVDDLFNYTKAN
                     NGSLVEYPESIAIEKEDFFATDCDICIPAALGNQITEDNAHLIKANLIAEGANGPINVE
                     GEKILLEKGVTIIPDILCNSGGVITSYFEWLQNRNGELWNMEEVITRLDKKLKDSYTRV
                     SDYAKLEGVDMRKAAYCIAIQRIEKAYVQRGIFP"
     gene            complement(27300..27467)
                     /locus_tag="HER15_RS06295"
                     /old_locus_tag="HER15_06295"
     CDS             complement(27300..27467)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HER15_RS06295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HER15_06295"
                     /product="hypothetical protein"
                     /protein_id="WP_156167091.1"
                     /transl_table=11
                     /translation="MNANPFNICPSCTEINICVLTKFKEKVWSCSEYNEVDVKKEKKQA
                     VIIEKEMQAV"
     misc_feature    complement(27500..27513)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.72"
                     /tool="antismash"
     misc_feature    28158..28167
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
ORIGIN
        1 attatttgat aatggtgtga ataaatatac aggaaactct attttcttag aagctcataa
       61 aagaaatgaa gctgcttata gtgaagcttc tgatcaaaca gaactagcaa ggtttggtac
      121 attatctctc aactttgtac tgttatattt gattcctctg cttatattat taatgggcta
      181 caatactttt actaaagaaa aagaattaga tacactacgt ttgttaaaaa gtcaaggtgt
      241 ttcacctgta agactagctt taggtaaatg gttttctatc tttattccag ttttcatatt
      301 aaatacaata gtttttcttg ttgttggcat attcctttct tccaacagtt ttacaggtct
      361 ttttagttgg aacaatttaa gtctacttta tacctcttac ttaatttatt atatgattat
      421 tgttaccata actatactta tatcatcaat tagtaaatct tcaggaattt ctttagttgt
      481 aaatatgtct ttatggatcc tgttttgctt cattacaccg aaaatagcta ccaacttagc
      541 aaacgacttt catccttacc caacgaaaca acaatttcaa gctagcatta aacaagataa
      601 agaaaaagga ctagatggtc ataatccatg gagtaaagag gctcaaattt taaaagaaaa
      661 aacattaaaa gagtacggtg tagatagtat tcagcaactg ccttttaatt acgatgctta
      721 cagaatgcaa aaaggagaag aacatgaagc tagagtttac aaaaaacatt atggtttttt
      781 aaaagaggtt tttgaaaatc aaaacactac ttatcaaaaa ctagccgtaa tttctccttt
      841 tatacctatt agaattcttt ctatggatat tgccaatact ggttatatag cgcattggaa
      901 ctttaccgat gcagccgaaa gttatagggt tagtactcag aagtttttaa atgatgattt
      961 caaaaacaat tcaaaaacag gagactggag ctacaaaacc gaagctgata agttttcaaa
     1021 actacccgaa tttaaatatc atactccaaa tttatctact atcattacct ggaactttaa
     1081 gaactttttt attcttttta tttggttgct tgtacctttt tatttactaa ttactttctc
     1141 taaaaaatta taattatgtt tttccaaacc ataaattacg aattgaaaat tttatttaga
     1201 aatggatgga ttacactttt aactgtaata cttctttcta ttataggttt tgctacatat
     1261 aatggacaaa aaaaagtaaa acaacgtacc gacgatatta ttaaagtaaa acaaaacttg
     1321 gtagagagtg atactaaaat gctaaaaaac attcttgata ttgaaaacgg tatagacaca
     1381 ggactccctt attggatgct ccctaacaat ccttcaactg ttggtacaag acaccctagg
     1441 gttgttgcta tggatgctca acctctatct tttattgcta caggtcaaag tgatttatac
     1501 actcatttta tgaagccaag catatttggc aataattttg cactagatta tacagaaatt
     1561 gctaaccctg tccaattatt gtttggtacg tttgatattt cttttgtatt tattttcata
     1621 ctaccattat taatcattgc atttacttat aatattttat cccgagaaaa agaactaggt
     1681 acattaaggc ttatcggatc tcaaccttta acaattagaa agtggttgat tcaaaaatta
     1741 ggttttcgtt ttattttatt tgctagtatt tctttagttg tttttttagt ttgtatttta
     1801 atttttacaa aaaatgctct tttaaacttt tctcaattat ttgctactat tatgttatta
     1861 attgcttacg aagctttttg gttttcgctg gcaggtattg ttaatttaaa gatcaataat
     1921 tcttctaaaa atgctttatc tcttattggt ctgtggttac taattgtttt agttattcct
     1981 gcaactgcta atcaaattag tacctctata taccctacac cttctcgctt aaatatgatt
     2041 aatgagatta gagaagcaaa tagagaaatt gagaaaaaac aagatgaaat tttagatggg
     2101 tatttacgag atcatcctga gttagctaat aaagaaaata aaaattttac tttctggcat
     2161 cgttattttg cctcacaaga tttacttgaa caacaacttt ctcctttatt attaaactat
     2221 aataaggctt taaaaaaaca acaacaggtt gttgattatt ttaaatatac atctccagct
     2281 attctcatgc aagaagcttt aaataaaatt gctggaacct cagctaacga ttacgaaaat
     2341 tataaacaac aagtagtatc tttctccaat aaatggagag accacattgt tccgctttta
     2401 tttaaaaaca aaaaatacac aatagaaacc tatcagagtc gtcctacttt tatatttaaa
     2461 cctttagaac agaaaacaac aaaaaactta atagctattt taatgttgac ttctgtagtg
     2521 atactcactg gttttcttat taagaaaaaa acatcttatt ttagttagtc ttttaccttc
     2581 ctaaaaaagg gtatagactt cattagtata aaaattaaaa aaccttggaa tgttccaagg
     2641 ttttttggat aaactaaata ttttaataat actcctataa taaaaacaat attaatttgc
     2701 aggatctaat ttattaattg ctgtaatcgt tcctccttct acttcgattc cctgtgtagc
     2761 ttttgctgtt ctagcatcta tattgtaaac atagctcccg ttttttgttg ttataccaat
     2821 ataaactatt ccttcagctt tagacacata atgccctttt gatgcaatac tttctatttc
     2881 ttcttttgta ggaagcccag ttacatctgt taatgtttta gcatatacat ctacaatagc
     2941 caaatctttc ccagaactat atgtcccttt tgaagctgta tcgtgcaagt ttactaagaa
     3001 tttaccattt cctaaatata aatgagaagt aacatatcta ttacctgaag cttcttcaat
     3061 gttataataa aaagcttggt caaatgctgt ttctcctttt tttattcttg ttattgctga
     3121 tggttttgta gatgttattt ctccattagt tgttgctaca gaagaagaaa aagcatatgt
     3181 atctcctttt tcatctacag acaaaccatt gttaaaataa cgtccaatat gactagttct
     3241 atcgtcatga atcgttttta catactccat ttctggataa gaatacactg caatattggc
     3301 ttcgttaggg tagttcgttc caaatctatc tgtagaattt cctttaattg taaaataagg
     3361 caaatacaca taatcaccta cttgagttat ccaagtaaag aaagctaact caccattttc
     3421 cttatttgct aagtccttag tattaatttg tccttcggct acaaattgtg atgttctggt
     3481 atcaagacgg taccaagaag ctatagggga gtcagaattt cttgatattt ttattaatag
     3541 taaatcgtct ttaactggcg caaacgcttg tacagtttct gattggaagt tagataactt
     3601 ttctaatgct cctttatcgt ctaactgata ggttgtaaca gctcctgggt ttccttgtcc
     3661 gtataataaa ctaaaaaact tattattact agttacataa taacgatatg ttccatcttg
     3721 ctcaataccg tttcctactg tgctaatttt tccttgggtt aaattatctg ttgtaagtat
     3781 ataatctgca actccttctg atgcttttgg tgtcgcagtt attaagtatt ttgctccttt
     3841 ttgaggtgtt tctccctgtt ttggagtatt atcatcacta catgacgtaa aaattgccgc
     3901 tgcaataaat aaagctgaat aaaggttttt gtacttcatt tgttttaatt tataattgtt
     3961 atttaattat cttctatata tgtgttctta aaaaaaagtg tatttaattt ttcctgtaaa
     4021 atttctacta ggtttttgta aactaaaatt gtcataaagc tcagcattta acaagtttct
     4081 acattctaaa gtaaattgta gtttcttgtt taatgagtat gtaaaactta tatcatgtga
     4141 tatttgttga ggaatttcaa gtttattact tcctaaactt ggccagtaca aataaaaatc
     4201 atgaacaaat aacaagttat agactacatt taatttgtct tctttattcc atagattaga
     4261 aaaagtgtag ctcacatcag catttccaaa taaataaggc tcgttaggaa ctcgatcttt
     4321 gtaaacaaca ctaacttctg tttgattatc ttcatatttt gtgttatttc ttaagttttg
     4381 ataagttatg tttgctccta gtgagacttg attattaaag ttatatcttg cctctgcttc
     4441 tacaccaagg ttggttacac tcgctaaatt atccataact tgcctacttt gatttttatt
     4501 aagtgtaggt ctaatgaaat cttttgcatc tctataaaaa ccatttgcat taaaattaaa
     4561 agagtgatta ctgcttgtat gcttccaaag gctaactcct aaattataat tattactact
     4621 ttctggtttt agacttaagt ttccttctaa attaattaca tctccataaa gttcatttgc
     4681 ttctggtaaa cgataacttt tttcataaga agcttttaat tgtatatcat cgtttacaaa
     4741 atatgttgca gcaagcccat accctgtatg attaaactta ttaacttgat ttctatacgc
     4801 tacatctccg tagtttccac taggattata tgcctctgca aacttatttc gttgatagta
     4861 tttttttata aaagctgaag tattccagtt tgaactttta aaatcatagc ctaaacccat
     4921 tacatttttc atcacttttt tggggtgttc gtaaatttcg ttatctggat ttaactcatt
     4981 atgccctact ctatcaaacg tattaagagt attactaaat gtaattttat gcttatcatt
     5041 caacttatag tttaagcttg ttgttgtaat acctgcgtta tttttgtatt tatataaaga
     5101 atacgaacgt tctcctccag ggccatcata ttctttaaaa tctccaaacc aattgtaacg
     5161 cctatgtaac gtatcaatat ttttttcttc tcccaagttg atattagcgg ttaacttaaa
     5221 atctaagttt ttaaatataa agtcgttctt tttatacttt acactaggca ttataatatt
     5281 accttttgta tgccaagcac caaacacgct taccattctt gctcctgttt gaatttctct
     5341 ataactctgt cctagggtca taccaaataa taattgatct gcgaactcag tatttacaaa
     5401 acctacatta aaaatggcta cttcgttatg gtaagtatca ttaaaacgtt ttactctttg
     5461 gttgggaaaa tattctccgg tgtttaaatc agatacatca acgtttactt tataattgtt
     5521 atcagaatag ttttgaaaag catttaattg cgcagtaaac ccagattttg ctacataaac
     5581 agcatttaca tgtgatctat gagtattaaa cgaaccaaaa gaatacgaag cttctaaatg
     5641 acttttttta tgctgttgtg ttataatgtt tacagctcct cccaatgcat ctgctcctaa
     5701 acctataggt actactcctt tatatatttc tatgcgttct gctaaactta ttggaatgtt
     5761 attaatttgt agagatgaac caaaattatc catgggtaat ccatcaataa aaaatcgaac
     5821 ttgatttcct ctaaaaccgt taagtgaaaa attcattcga gaaccaactc ctccactttc
     5881 tctaatgcgt actcctgcta ctctatctaa cgcatgtcct aaatctaaag aggtatgatg
     5941 taactgttta gcatcaacaa cacctacatt atatgctttt tcttttactt tttttacgat
     6001 actttttcct gttacaagta cctcatctaa ctctactgat gattcttcta attgtattga
     6061 taatactagt tcttctccct cttctatctt aaaaaatagt tccttagttt taaagcctac
     6121 aaaagaaact ttaagtacat attttccttt aagcttacct ttaaaaagaa aatgaccatt
     6181 tatatcagtt gaaactcctt tattcgtgtc ttttataata actgttgctc caggaattgt
     6241 ttttttccac gcatctacta ctgttccgga taatttagac tgtgtatatc ctacgaataa
     6301 aaatagaagg ttaatcgtta taaaacttat tgatttctta aatatattca ctttgttttt
     6361 atttagactt aattgaaatt aaaacaaaat tactcctata aaactgtaag ttttatacgc
     6421 taaacggata attagctacg ctaaacggag taaataatat tgattattaa gatgattctt
     6481 ttaaagcttt ttatttcttt ttattttgaa gaaaatacta aatgctgtta ttgaaagtag
     6541 caaccaaaaa gcatctacca caaaaatttg tgaatatcct ttttgccaag aaatccatag
     6601 ccaattgcct gtaatagcac catttgagat aggtactaga aatcctaaaa tacttcctaa
     6661 taaaagtgat attttattgg taaagtaatt gtcttttttt acgataaaaa gtgagcttag
     6721 tataagccat ccccagaaaa atatctgata aataaatact tttctattgt ctccattgct
     6781 gtttgaaaaa catttaacgc taataaaaac aagagcagtt attggatata agcttaaaca
     6841 tatagccata taaatattta ctagccaact attgaattta cgtttgtaat taggtacgct
     6901 ttttttatct cttgcaacta accaaataag tacaccagat atgattacaa aacaggtaat
     6961 aaaacccaaa accaagtaaa ttaatttcat tccataacca ccaaaatctc caaagtgtaa
     7021 tctttttaaa agatttgtag ctccttctat atatgataag ctattttttg aatcttttgt
     7081 ttgtactata tatccatctg aagctttgaa tgtgattgat cctgaactta aaaagttatc
     7141 cttatacttt gggtatcctc ctacttttac atgcatattt gcatctccat aattaaatat
     7201 ttcgacacta tttaattgta agcttgggta ttttttttta gttctaacta aaaaatcatt
     7261 aatagaaata gttttttcta attctactgc tttgtactca taatttatat ctttttcgta
     7321 attcaatgct tctgttaaag ctttagaatt atcattaaaa atatagtttt gcacaggtgc
     7381 tagcattacc atataaccaa taattaggta tgcgcctgta acagcaaata taaactgata
     7441 tggtagtcct attacaccga gtgcaacatg cgcatctgtc caaatagttt tccatttcgt
     7501 ttttggtcga aattggtaaa aattaggtac tatttttttc cagtgaacga taattcctgt
     7561 tataattgca aacaaaaaga aaaaagctat taaaccagca aaaacatacc cagatcgtcc
     7621 ataaaaattt aattgtgcaa aaaaatgtag cctgtaaaaa aattctccta aagaatagtt
     7681 ttggttataa tttgcttttt taaaggtttt taaatttgta taaaaaaaag ctcttttagg
     7741 ctcttttttt ggtgccaatg tatctttaga ctgccccatt ctggtgatta cattttgtcc
     7801 ttctatattt ctataaaaag aaatgtctct accttttagg taatactctt ctcctaaatt
     7861 atttaataaa gcatcaaaat ctccttctaa aaaaaagttt ttttcaacgg gctcatttct
     7921 ttcccaagct attatttcat ctcttaaaaa agaaatagat cctgtaaaaa aaattacata
     7981 taatgctgca cttataacaa taccactaat ggtatgtgta tgaaacatta tattatatac
     8041 tctcttagtc ataatggtat tttaatattt tattataatt gatttggatt atttaagtaa
     8101 atgactataa taaatagaag actaacaagg gtataaagtg cccatatttt ccatgcactt
     8161 ttggctaaaa aggctaaaat cattaaaacc gcccacataa taaatccaaa aaaacgtagt
     8221 gtcattatta catttggtat gtttaaaaaa gtcattaaca tgatgtgaaa ggtttctgtt
     8281 acaacatatc ctcctacaaa accagcactt atttttgcaa tacgctggat aggtgaactt
     8341 gtcaaatatt ttttatttgc tggcataatt atttaagata aacttcaagt aatagtgata
     8401 aaatcatcat aacaactaat attgagaatt ttaaaaagcg taaaggttca attaaaacaa
     8461 ctaaacttga cactaacatt aatagagtta aatatgaaaa tattcctgcg ccaaaaccta
     8521 aatataaaat cgcgctagtt aaaccaataa ttaacaagac tacacctata tactttcctt
     8581 ttattttatt ctcattaatc catttttgaa gaggtaaata aaatgttaaa tctgctctat
     8641 ttgaagtact gtataaaaaa taaaaaccta tgagagctaa acagcctata attgttaaca
     8701 tgctattttt ttttataagt tataactaaa atcgattttg tcatttttta tgttaaaact
     8761 aattttactt attaagacta aataaaaata aattattttt gtcttctgca aaactaattt
     8821 ttattcgaaa atcgggggat acgttaaacg gataaaaaac atacgttaaa cggaataaga
     8881 aagcatgaag gttaccatat ataataatga agaagctatt tttgataagc tatctaatat
     8941 taaaaatata aatgataatt tttacaaaac cttagtaact aactttaatg aaaataattt
     9001 taaaggttgg tataaggagc atgtatttga aaacttcaaa ataggttttg gctccataaa
     9061 aactataaaa ggctataaaa tatcttttaa tattaaagga gaaagtatag aaatgttatt
     9121 taacttaaaa gggaagttta ctatacatat acctgaaata gaaagtaagt atttttttaa
     9181 ctctaactca cataatatta acttttatag caatacaaaa ggctttttag agtgtgaatc
     9241 ttcagaatct tttattgtac gccttaactt atctccttta ttcttcattc agtatttacc
     9301 cgatgatatt aggtttgatg attttaaaaa aatcattagt gataaaaaat ttggtaaact
     9361 taattcagaa aactgcttaa taaattcaag aatgcatttt ttgataaaag aagttattgc
     9421 ctctgaatgg gataatcatt ttcgaaaaat acatattacc tctaaaatat tagatcttct
     9481 tttattacaa ctttatcagt ttacacctag tactcctaaa aaaaacacaa caaagctaac
     9541 tactactgaa gctaataaaa ttgaaagggt ttatgaatat atacttaata attatacatc
     9601 tccgctaacc ttatctttgt tatgtaaaga aattggcacc aatgaatatg ccttaaaaaa
     9661 aggatttaaa accacatttg gtattaccgt atttaaattt attgctaatt taagaatgaa
     9721 taaggctaaa gaactattat taaaaggcca taccgtaaat gaggtttctg aaaaggtaag
     9781 ttataaaaac ccacaacact tttctactgc ctttaaaaag aagtttggta cttctcctag
     9841 taaattttta agtgaactaa gtttttatga tataaaaaat taataaatgt cagtttttaa
     9901 taaaaaaacc cgaaactttt tttgtttatt tttttactaa tttacttcta attaataact
     9961 acttgtaagt gtattagcat agcagaaatt ttctagggtt ttaaaattta taccctagaa
    10021 aagttaaaaa gtcgaagttt aaatctttat taaaattaag gagtgctgtt cctacaccaa
    10081 ttattccatg cgacatggaa agttgagcat taatatcaaa cttattaaaa gttgtgtcaa
    10141 atccagccca ttcattatca tgtcttttat gttcttttgt ttttgtatac caatagttta
    10201 tagaatcatt aagaaaatct tcttctaatt cttttctaaa cttttttagt aaagaagcaa
    10261 ttcctaatga accataaaat aaattagcat ctgttaagta tttattttca tcatctttaa
    10321 aattagctgc gttttttaat gtttgattaa ttacctcttt gtaaacttct aaattacacg
    10381 ccttaactgc tttatgaatt ccataggcaa ttccgagatc tccgtaattt aaattgaaag
    10441 aaaaagatac ggcatcttta acgttatttg tacaaaaagg aaaaagaaat gttttgtcct
    10501 ttaacttaga ctcaacaaca tattttatag cttcatttat tagtttcttt gtcctttttt
    10561 tctcaaatcc taacccatat aattcaacta aaaaatctac aattccaatg actccatgtt
    10621 ttactcctaa ctctactaaa tatcgccctt ctctttcaat ggtagaaacc caataaattc
    10681 cagtcgtttt tttatctttt tttgctagtt tttctatttt agaaagaatt aatgaaaata
    10741 attcatcgta attttttccg gaatccttgg ctctatttat aaaataatta ccatacttca
    10801 atattcctgt aactgggttt agattgtctt cttttaattt atctattaaa agttcttgaa
    10861 gaattgagtc atagttatcg aagtaaaatg ctacttcttc tttttttata acaccttctt
    10921 tgatgtaaaa atcaagcaga attcctattt ctataatatc tgctataata tcatttcctt
    10981 tatagtcttc atttaaacca ctgattgatt tctctaaaaa agagagacac ttatccttat
    11041 tatccttata atgataaaaa agagaaactc ctgctaatcc gttaacaact cccatagaag
    11101 ttaaaattcc ataattattg ttaattgatt tttctatttc taaaattata ttatttgtat
    11161 ccatttctaa cttcctaatt ctaattgatt ttttactaaa ctaaaatagt ctcctttctt
    11221 acctactaat tcatcatggc ttcctacttc acttactttc cctttcttta acactactat
    11281 ttgatctgcg tgttttactg tactaagcct atgagctatt attacaactg ttcttccttt
    11341 aaagaagttg aataaattat catgaatctt cttttcattt tctgcatcta acgctgaagt
    11401 tgcttcgtca aaaaacatgt aatgtgggtt tttataaacc gctcttgcta ttaatattcg
    11461 ttgcttttgt cctccagaaa gtccactacc tgaggctcca atttttgtat catatccttg
    11521 agctaacgaa tcaatatact catcaatatt cgctattttt gctgcctctc ttaacctttc
    11581 ataatcaatt tcttcatctg atgtcgctat atttcttttt attgtatcag aaaaaataaa
    11641 tccatcttgc attactactc cacaatgttt tcttagactt ctaggtgaaa tatttaaaat
    11701 attttggtca ttataactaa tatgacctcc tatagagtta taaaacctta acaataactt
    11761 cattaatgta gtctttccac ttccgcttgc cccaacgatg gctgtaactt ttccgtccgg
    11821 aatgtataaa tcaatattat taagaacaaa aggagacctg ggaccttcat actgaaaaga
    11881 aacattactc aacttcacac ctgtattagt accattattt gataacttta actcagagta
    11941 tgattctttt tcttctggat cttcattttg tacttcattt aaccttgata aacttaattt
    12001 tgcgtcttgt aatgatctta taaaattaat caattgatct acaggagaat tcatcatacc
    12061 tattatgtat gaaatactta ataaaacacc taaagtcatg tctccgttta ctactaaaat
    12121 tgctgtataa aaagatacta gtatattttt tacgtggttt ataaacgtga agcctgatga
    12181 ttgaatttga tctaatctta atatttttaa atttatatta aacaatctat cttgaactgt
    12241 tttccattgg ttacacttat actcctcaaa agagttcaat ttcatttctg ttactccatt
    12301 tagtatctcg tatatcgttt cttgattgtt actgttttca ataaatctgt tataatctaa
    12361 tatttttctt ttctttaaga aataatgaga ccacaacaca gacagaagtg ttaatgatgt
    12421 ataaattaat agtattgtta tattatagta agccaatact ccaaagaata ctgaaaaagt
    12481 aatcattgag aaaaatgtag ttattgattg tgatgttaaa aagtattcta tcctatcatt
    12541 atcttgtatt ctttgttgaa aatctccgat aagctttgag tcaaaaaact ttaaaggtaa
    12601 gtctagtgtt tttaacaaaa attctgaaat tattttaata cttattttgg ttcctacgac
    12661 taataatgac cagtttctaa atatctctat aacaattact cctaggtaca aacttagctg
    12721 agagaataaa atatattcaa tatagtttac atctttttta tcaattcctt tatctattaa
    12781 gtactgagtt aaaaaaggaa aaaccatatt tattaaactt cctagaagca ttaaaacaaa
    12841 tacaaatacc aacttttttt tatggctttt aaaaaagtct ataaagtatt ttaatgatat
    12901 tttttctggt tttttaaatt ctgtatttac gaacttattt tgtggtttta agaacaatgc
    12961 aactcctttt ccattttccc ctaaccatga tttggaaaat ttctcatcat ttaaatttac
    13021 aaaaccatgt gctggatctg ctatttgcca tttctttttc cttgctaata aatgtggtct
    13081 tttatgttct tttagaacta caaagtgatt attattccaa tgtaaaatac atggataatt
    13141 taaattatct atatctttta actcttgtag tcctagagta gctgaaaaag tctcaaaacc
    13201 taactttttt gaagcttcat ctattcctaa taaagaaact ccttcctttg ttatataaca
    13261 cttttctctt aggtaattta gtgatatttc ttttccgtaa tgacttgcaa ccattcctaa
    13321 acaagatggg ccgcaatcca ttttatcata ttgtctaata agcttcattt tcaacttgtt
    13381 tttggttata ctttctctta ccaatctctt ggttataata tctttctaaa attccataca
    13441 ttataagttc atgaaaccta ggatttgctt gcacaaatct atttacatgc atgtgaatat
    13501 agctccatag caaatcatct aaattttcct tagcttctat gctcaattga acttctttta
    13561 acgctaaata cctctcttta tatatgtttt ttacctcaat ttctggtatg tttaatatgc
    13621 tgtttatatc ttttacatat tttctaaact tgttgtttac atcttttttt attgttttta
    13681 ctttaccata ctcaacccaa aaactattaa acatagtatt tataatttga tgtcttttaa
    13741 ctaaactgat gtcaaaaaca ttaaaaaaat catctattga ttttaaaata aaaagccacc
    13801 ttctactctc tccattatct tttagatatt ttaacatgtt tacggtgtac tctgaatcta
    13861 tatgaaatat agtttcagaa ctctctatat tttgccaata atacctttcc aactctctgt
    13921 tgtatgttga caagtctaac ttccatattt tttgttcttc taataaatgt gataattcat
    13981 tatgaataat cttagacatc tctgagtagt ttttttcatt ttttaaatga aatcttaacc
    14041 ttaagtgaaa atctggatcg gtaaagcgaa taaaaaacca cttatctatt atgcctgatt
    14101 cttttaattt tgttgctatt ctagaaatgt tttcaattaa aagttgatct gatgttattc
    14161 ttcctgtata aagcttaaaa tatacccatt catcaccgta aataaaggtt ctctttacat
    14221 tattgttttc aattttatgt gtagtagaaa tatttttaaa tatatttaat tctttttgag
    14281 atttaacaac tccaatatat tcattcgcat agctttcagg tgtttcatta ttatgcatat
    14341 cgtaaataca ttctgtaact cttaaaattt tatttttttc tatttcttga tatagtatgt
    14401 taagtgtatt gtagttttca atatcaataa tcatcttatc ttcaccacca ctagttatat
    14461 aaatatacct tgggacactt ttctttatta aatctgcttt taggctttct attcctttgt
    14521 tgttatcttt ctttaataac catgttgctt ttcttagaat tacatcttta ccgtatgtta
    14581 accttggaca atattctaaa tcccctatat taaaccctcc aaagtttatt gaataatcat
    14641 tatgacgatc ttgtgattgt aagtcgcata aaaaatgata aataggcaat gaattgtaat
    14701 gataattttg agctgagctt aaaaaaggaa caacttcttt attctctttt tttgatctaa
    14761 gaacaattct atttcttttc aagctaatgt ataagtcatt tacatctata actttggtat
    14821 taccagaagc ttttgatatt atacttattt ctgcatctct atttactttt cttattagta
    14881 tgtttcctgc tctgttatta ggtaggtgaa taacttctgc tacaatttta tttttaagta
    14941 acgacttttc aaaatctgtt acataattaa taatctcttg aacttctgta tcactattac
    15001 taaatcttcc tattagattg gttcctgttg ttcctccaat gtgtttaaga tatattttat
    15061 ctttagtgta tgaataagaa atagaaaagg caccattttt tgcttcattt tcctctttga
    15121 aaatggttaa atcttctttt gctaaattta tttctttctt ttcagggttt cgaagtaata
    15181 aattaagcca aaaattatga acttttgttt ctacttttct ttctgatgta acttttcgaa
    15241 cttgtggcat agtcacatca tctattaaat cagaaaatat tacttcctct tttaagtggg
    15301 gtaaataccc tattcccaac tcattatcta aagcttcaac taatgctact tctttatctt
    15361 catacctatt ataaaaactc cttttaaata cagttaaatt tgaatcttct tttatgtttt
    15421 ttttagatac cttagataaa acactcatta atttatttaa ctttatatct atattttctg
    15481 tatcatttat acttttggga atctttttta aatttgaatt aatgacaaat ttttctttaa
    15541 aatcaactcc tatttttctt aaatctttaa agatttcatt ataaatatct attgaattga
    15601 aaactttttt atctaattct atcagctttt ctttaacttt tattaatgat gaaaatattt
    15661 tttttaactc ttcatctgta tctattttgg aactattttc tttataaaaa ttaattactt
    15721 gatttaaaag gtcttcttca tttaatgtag cttcaaatga gcttatatat atttttgaat
    15781 ttattaaatc taataaatag gcagtcacct cttcttcttc tactccatct actaaattta
    15841 atatcatatt ttttaattct tcaaaagtca ttgtgtcatt ttcatgtgac actaagtaat
    15901 ctattaactc atcactatct attgaagaaa gtgtgtaact tatatttcct ttagaaaatt
    15961 ttggttctat atacctatac ttgtctccta ttttatatat agtattgttt cttctatatt
    16021 ttactgtttg tataataatc ggatattgat taaggtgatt taataagttt agcaaatact
    16081 ctaaatcaat acttgaatac ctcttatact ttttttcgtt atctaaacta ctatttgagc
    16141 ttaaagtagt gtaagaagta aaaagaccaa aaggcactgt atttgaaact gatcttaaaa
    16201 agtattttag tatagcttcg tttatttttc ctctttcttt ctcttttttt actacttttt
    16261 cccattcttt atataaacta ggagatgata aataaaccgc ttcagagaac tccttattaa
    16321 aaaataaaga atctataaaa ctatttagct ctttttcttt ttcaggaatt tgattgtatt
    16381 tatttaaaga tagtaatggt tgtctgatta ttttgtttgg taataaacta atatttttca
    16441 tcttaaaacg ttttaagtac ttgctgtgtt gttaattctt ttattaattc taagttttct
    16501 aacttagctt ctatatcttt ttcggtatcg catattatga cttcatttac cccatatgct
    16561 ttttgaattt tctctaattt ttctaaaaaa gtatatttat taaccggaat aattttcaag
    16621 ccctctcttt tgtttttata tttcttctct tcttgctcta cttgttcttt tgtttttgaa
    16681 aaagtaactg ctattgctat agctacttct ggaagttgcc cgttcgtttg ataatactct
    16741 tctttatatt cttgtaaccc tttgaggtct tcatcgtatt caaaaacatc taaaccgtgc
    16801 attagagacc tacatatgtt taatttattt tttattgcta aatctttttt cctataactg
    16861 ttagatagat accataagga aggtgcaatt cctttaaatg gaggaagtac aatcttgctt
    16921 tcattgtatt ttttttcttc ttcatgcagt agttcacata tcgcttgaag gtttttctcg
    16981 tacatcgtat tttcaaatgt gctattattt aaattgaaaa aattatgttg atgtgcgttt
    17041 tctggacgtc ctttagacaa accaaaatca attctgttat tataaatatt attaagtagt
    17101 ttataatttt gcgccaaaga atatggcgag taataaccta ttagagatcc tgcagatcct
    17161 atcctaatat tttctgtcat acccgcaatt agggtcatta agatctcagg gttattgtat
    17221 ggatgtacag cactagctct gtggtgctct gtaagccaaa atctagaaaa atttaactca
    17281 tctgctctac atgcataagt aaaaatatct tctatagcat gcattgaatt ttgtttattg
    17341 ctagctgcaa actctagtat tccaattttt aaaatatcgt ttatcataat agtagtattt
    17401 tggaccagtt aaattcttct tctctttcaa actctaaaag agataaagct gtagccggca
    17461 gattatttaa aaaattaaga ggatgttctt ttatagtact ttcagtaaga aagtttaatg
    17521 tttttttata ccaaaagtta gatgcttctt tatactttga gtttctagtt tttttatata
    17581 agaacatgta tgtttttaac actcctgaac tcccaaagta aaacctatga tcccaaattc
    17641 ttgtatgttt ctcttctctt ttttcaaggc tttctaaagc tattttatta gcaatagtta
    17701 gtagctcatt agttttaaat ttttcattta atgaatatat taatgtagaa aaattcacat
    17761 cacaattaga ccaggctagc acagctctat aatttaagcc tttttcaaac tcatctcctt
    17821 tgtgaatact tctaggcaag tagtatttct tgtctttgat tatttgatat tcattctttt
    17881 tcataatatt cattagtcta tctaataaat atcttacgaa atactctgct ctttcatcat
    17941 ttatatcatt taaaactttt attatcgcac ataatccgtg ggcataacca atgtgcacgc
    18001 cttctatata tgtgtattca ttataaaata aaaagttttt atcctctttt aacttttcaa
    18061 acaaagcttc taaaactcta ttaacaagag gtttgctatc tacataattt agataaaata
    18121 aaattccaaa aggacctcta acgaaatcat aattattatt ttgaattaac tcaatagctt
    18181 gatctactac tatgttattt atttcttcta gttgtgaatt gtaaccttca tctattattt
    18241 tttcttcaat tagtaactgt aaaacatacc ctaaaccact caaaccattt tctaatgtag
    18301 aatcatacat taagctagaa acaccttttt caatatttgt aaaaacagac tctaagtttt
    18361 tttctattct ttgtaaatga tcttctttat taaaaacctt ataaagacat aagtagtaat
    18421 aaacaagtcc taactttcca tttaataaac tatctgactc taaatcttct ctttttattt
    18481 tatctatatt ttctattaat ttatgtgctt ctttcatttt gtatgacttt aaaatacagc
    18541 agcaattaaa ctgctgtatt tattattatt ttaatagagt tatatttact ttgcaatttc
    18601 attttagttt aaaacttgat ctgcagatcc attacacgtt cctgtatcac aagacgcatt
    18661 acatgtaaaa tttaaacaag aaatacttgc tgcgtctcta acccctcctt ttaattgaga
    18721 catttgagct tcttgaagtt ttgtaattgc ttctttattt aactttaatc ctttgtttag
    18781 tgtgattttt ttcatcttta tttattttta gacaaggttc ttttaggtta aaaagaacct
    18841 tgttctatta attactattt aattaataac ttgatcttta caagagtttc tattacaaga
    18901 tttaatacaa gatccatttg cacaagtaag accttctgct tctcttactc ctcctttaaa
    18961 agaagacatt tgtgaatctt gaagctttgt aattgcttct ttatttaact ttaatccttt
    19021 gtttaatgtg atttttttca tctttttgtt ttttaattaa ttacttgatc tgctcctcct
    19081 ttacaagagt ttttattaca tgattgtata caagatccat ttgcacaagt agctcctgct
    19141 gctgcattta tacctccttt aaaagaagac atttgagaat cttgaagctt tgtaattgct
    19201 tctttattta actttaatcc tttgtttagt gtgatttttt tcatcttttt gtttttttaa
    19261 ttaattactt gatctgctcc tttacatgaa tttttattac atgacttaat gcaagatcca
    19321 tttgcacaag taagaccttc cgcgtctcta attcctcctt tgaaggaaga catttgtgaa
    19381 tcttgaagct ttgtaattgc ttctttattt aactttaatc ctttgtttaa tgtgattttt
    19441 ttcatctttt tgtttttatt attgtattcg gttagcatta caagaatcct cattacacga
    19501 cttaatacaa gatccatttg cacaagtaag accttctgct tctctaactc ctcctttaaa
    19561 agaagacatt tgtgaatctt gaagctttgt aattgcttct ttgtttaatt ttaacccttt
    19621 gtttaatgtg atttttttca tctttatttg tttttattat taatgaataa cttgatccgc
    19681 tcctttacaa gaatcctcat tacacgactt aatacaagat ccatttgcac aagtagctcc
    19741 tgctgctgca tttatacctc ctttaaaaga agacatttgt gaatcttgaa gctttgtaat
    19801 tgcttctttg tttaatctta atcctttgtt taatgtgatt tttttcatct ttttgttttt
    19861 taattaatta cctggtctgc tgatccatta caagagtttt cattacaaga tttgatacac
    19921 gatccgtttg cacaagtaag tcctgctgct ctaatacctc ctttaaaggt tgacatttga
    19981 gagtcttgta actttgtaat tgcctctttg tttaacttta atcctttgtt tagtgtgatt
    20041 tttttcatct ttaaaatttt atattgaatt aattatcagt tatattttta agactttaac
    20101 tgtttttcgg tctgtaaacc ttggccttgg ttattttata tactcaatta ttattgagcc
    20161 ctattttgta tatctctatt acctgatcta tctctttttg ttctaatatt tttatttcca
    20221 aatgtgtatc ttactataaa acttaatgat cttgaatcgt aatagttatt ataagttgtt
    20281 ttaacattgt tataataacc tgtcacagta gttacacttg tttttaaaac atcattagca
    20341 tacatcacta ggtttaaatc tccttttagt agttttaatc taagagataa gtctaaagga
    20401 ccgtaacctc catgtcttga aacattttgt tttgctgcaa aaacatggta ataattaacc
    20461 cctagtgata gcgttttttt agaatttaat tttatatagt tctgagtttg tacaaaggca
    20521 ttaaaccctt cttgttctct aatagtttca ggtattgatg aagacatttt agaataccct
    20581 atatctatcg tgttgtatga agtcaaccat tttaatttat caaagatata cgtatctgtt
    20641 attccgtaat tttctatatc taaatgatta taatacgtat agtttaccac tttacttaca
    20701 ggatctaact ctgaaatttg ctcataccct tctgtaatct tttgactata tacctttaat
    20761 tcgttctttt tagaattaaa tattagttct gtgttagtaa taaatgaagg ttgtaaaaac
    20821 ggattacctt gtattgtttt aaagggattt acaactatct taaaaggatc taaactttca
    20881 aatctaggtc tatttaatct cctacttaca ttaaacgata gtgactgttc tccctttaat
    20941 ttgtatgtaa ggtatagtgt aggaaaaaac ttagtatatt tattttcgtt cgattggtta
    21001 tttgatttag agtatgattt agttactgtg ctctctaatc taagtcctgc ttttgcacta
    21061 aacttttctg aaattttctt agttcctgat acatatgctg cataaatatg ctcgtcataa
    21121 ttaaatacat tagattgatt ctcatctaaa actggggttc cattaaagct gtcataaaac
    21181 ttaaagtcat tattagtttg agaaaaagac actttacctc ctaactttat atctattgaa
    21241 ttatagggta acgatacgtc tatttttcct gaaatatttt caaaatcata atctatactc
    21301 gtattgtttg aaaaagtagg agttatcgta ttttgttctc tcctttctcc tttattttca
    21361 ccttctttaa acgaagtaga cttataataa tctacatcta acgaaatctt tttccctaaa
    21421 ctatctagtt taattgtatt gtaaaaattt aacgcatggc tcttggcatc tttgttagaa
    21481 actccatcag ataataagga atactttaac tcatccttta aatcgtaaat caaatcttta
    21541 ttacctgtcg aagaaattat atctgagttt gttcctgagt atcctaaccc taattcccat
    21601 ttttcagtta aagtttgagt aaatgacaat ctataattta aatactcgtc ctcatattct
    21661 gaaggtccat tacccctcca tgtttcattt gaaaaaaagt tattatttct aaaaatgttt
    21721 ctttttaaat aaagtccatt agaaatattt acagttaaat atgtattttt ctttttgtaa
    21781 tttagagcta aacttcttcc gtaggaaaat aatgttctct gggtacttga catgcgggct
    21841 acggcactcc aaaaatcttt tttttctttt ttaagaacta tattaattac tcctccattt
    21901 ccttcagcct caaactctga aggtggcact gttattacct caactctaac aatatcagag
    21961 ctattaatac tggctaagta ccctcttaaa tcatctcccg tcaacggcaa cattttacta
    22021 ttaaccatca ctcttacaaa actttttcca agcattgtta attgatcatc tctaataact
    22081 atatttggtg ttaccctcaa tacttctacg gcagaaccta actcttgagc aactgtttta
    22141 tctatattaa aaactaaacg atcgtttttc ctaactaatg tttgtttttt actagttatt
    22201 attacttctt taagtaagct tgtgtcctct tctaaaacaa tattacctaa atcattagtt
    22261 gttacattga tttttttggt tttaaaacct agaaaactta tttcaataaa aaatgaagtt
    22321 ttttctttta cttttaatct gaactcccct ctatcatcag tagttactcc atctataagt
    22381 ttattattta tagaatcata taaaattaca ttggctagag aaattggctg tttttctgta
    22441 tcaacaacca ccccattgta cgttatttgt gagaggatat ttgtacacat taaaagcaaa
    22501 atcatattta aaacctgttt cttcatttct ttaatttatt ttattatact tcaaatttaa
    22561 atgacctcta catctatctc attacactaa agtgtagtta accaactgac tgtcaacaac
    22621 tacactttta ggtagttttg atttttttac tgaactatcg tctattgatt taaatatcaa
    22681 atgcttattt tttctataaa accctattaa acctgaataa gtcatacaca caggtatagt
    22741 ctctgagcct aaatagttca ctgcctcacc aaccacagta gcttctattc ctaaaattct
    22801 taaaactctt aacaacttac tatcacactc agcgaaagca acagagtttt ctttttcaca
    22861 aattggactt attgcacaaa tcattagttt tttaaaaagg tttatatcac taacctcttt
    22921 ttttattgcg aatctaccta tgtgccaaat tgtttttaaa ggagacatac ctgcaatttc
    22981 tatcgggtta attccaaata ttttttgaat tggtaacttt cttgagtaat cccatcttag
    23041 cactcttata gcaccttgaa tttctccttt gtcatttttt gaaacaaata cttttgagtt
    23101 cttagaaaaa cctagctctt ctttataaat agattgaata cttgaataat aattacttgg
    23161 taagcttcct ttagtgtgat gtttaaaatt ctctttaact atgaattcag ctaaatttat
    23221 catttcactt gacgataata tttctaagga tttgttttta aaagtcataa cattgtgttt
    23281 tatactctca aaactatcta tagactactg cttttcaatt acacaaaagt gtagttaaag
    23341 tattgatgat caataaacta cactaaagtg tagttttatt agacataata atatactttt
    23401 tagtagattt gttagaactc ttcaatattt ttaattatgg aaaacaacat caatgatttt
    23461 ttttcaatga aaaacactgt tgataatatt tctgaaaatg aacttcttaa aacatctgat
    23521 tatttagctc ctataaaagc ttttgcaaga actacttata aaagtattta tattattgac
    23581 tatcaaaaga aaggatttga atatgtttct gataacccct tattcttgtg tggtcataca
    23641 tctgaagaag taaaagaaat gggatatgcc ttttacttta agtatgttac acctcccgat
    23701 ttagatttac ttttaaagat aaatacagta gggtttgatt tttttgaaaa actgcctatt
    23761 gaagaaagat tattctacac aatttcttat gactttaata tcaaaaatca agagaaaaaa
    23821 accattttaa taaaccaaaa attaactcct ttatttttga ataatgatgg taaagtttgg
    23881 aaagctatat gtattatctc tttatctaca gaacaacact ctggaaatat caaaatatac
    23941 aaacaaggag acaacaaaat gtttacttat aatctagaag gtaaatattg gaaaacagaa
    24001 gaaaaaataa cacttacaaa tagagaaaaa gaaatattac agtattctgc aagaggtttt
    24061 aaaatcaatg aaatagctga atctattttt gtatctcctg atactgttaa atttcacaga
    24121 aaaaaattat ttgacaaatt agaagttgct aacataacag aggcaatttc ttttgctacc
    24181 aataatagac ttatttaact attaattgac gacaagtaaa attcaggaaa ttttttcaca
    24241 ggtttcccca ctgaaatatt aaacagcaag tgcgtacaaa tagacgctac taaccatgag
    24301 gctacagata gttgaggagg aggtaatact tccttctctt ttttatattc ttctataaca
    24361 tcttctatcc atttctgagg ctttccccaa aacttcatat aacttactgc gtattctacc
    24421 atttttactt cgttaaactt ctcttcttct ttggctattg attctaacga taaactatct
    24481 ggtgtgatta cagaaactaa agctccccag cctaaattat atggatgaat aattggcacc
    24541 cctttatctc tacaaatctt atcaaacatt aatggtatgt cagacgtaaa atctaaagca
    24601 tttaccgcta ctttatgtcc ttcaattatt gaatgtatat tttcttttgt aataaaacaa
    24661 ttatgaaccg taatatctgc tttcggatta attgataaca atcttttaga aagcgcttca
    24721 actttatccg ttttaatatc atcttcagta taattttgcc tattcaagtt tgatagctca
    24781 acctcatcac catcaactat agtaattttt tcaaaaccta accttaatgc acattcagca
    24841 atattactac ctataccact accgcctaat aagattggat aattctttat cagttcttgc
    24901 tcttctggtt taatatatat tctatttcta ctatacattg attttttcta agatttattt
    24961 aaacaaaaat aattaaacat acctaatcaa atcttacact aaagtgtagt tattaaaaga
    25021 ttaaagctca taatattttt taaaacaaaa aaaaccttgg aactacatga ttccaaggtt
    25081 ttacaactaa ctctacaaat ctaacatact tgcttaacaa gaatgctatt cttttaataa
    25141 gacttcatca aaaaatttgt ctttaagttt ttgataagct tctaaattat tttgataatt
    25201 ctcacgtaac ctatcgtact cttctaaata agccatatcg cactgtatat cgtcacattc
    25261 tgctacattt acataggtat ttgaatatga taaaacagtt ttataaagct cattatttac
    25321 tttttttctc ttagaaaaga gttctagtat ttctttagaa atagttttat tgactaaaga
    25381 gtattcatgc aagcttaaaa ggttctcaat ctctttatta atatactgta actgatctac
    25441 ccatcctttt aattctacat ggttgtattt atgtactaca tctatatcgc taccgtgatt
    25501 attaagtgtc atttttttat ctttaaatta aggtgctgaa actttcgttc tttttttctt
    25561 gaactacttt taaaatttta acttctttct tccctcctgg taaatcccaa tgaactacat
    25621 catttagagc ataaccaaat aaagctatac ctattggcgt taaaatagaa accttgttgg
    25681 ttttcaaatc cttttcagtt ggtcttacaa tctgaatagt tttttcccaa acatctccag
    25741 aagctatagt cacaacagta tttaagcgta tgacatcatc aaacatttgt tcttcatcta
    25801 aaatttttgc tgtttttaac tcctcagcaa acttgcctaa tgatgtttgt actttacttt
    25861 cttcagtatg cgctgaaaca ttaagtaaac tcttaatgta cacatactct tttttctcta
    25921 aaactaaact tccgtgtttc attttactcc tttttatgga aaaatacctc gttgaacata
    25981 cgctttttca atacgttgta tcgctataca gtaagctgct tttcgcatat caacaccttc
    26041 taacttagca taatctgaaa ctctagtata ggagtctttt agcttcttgt ctaatcgcgt
    26101 aattacttct tccatattcc acaactctcc gttacggttt tgaagccact cgaaataact
    26161 agtgattact cctcctgaat tacatagtat atcaggaata attgttactc ctttttctaa
    26221 aagaattttt tctccttcaa catttatagg tccgtttgct ccttcagcta ttaaattagc
    26281 tttgattaag tgtgcattat cttcagttat ctgattaccc aatgctgctg gtatacaaat
    26341 atcacagtca gtagcaaaaa aatcttcctt ctctattgct attgattctg ggtactctac
    26401 caaacttcca ttattagctt ttgtataatt gaaaaggtca tctactttaa ttccgttcgt
    26461 attttgaata cttccgtaag catcttgaac ccctatcatt tttgctcctt cttgttctaa
    26521 aaagtaagcc gcccaatacc caacgtttcc aaacccttga acaataaaag tttttccttc
    26581 taaagtttgg ttattttctt ctacccaaaa cttgatggtt aagaaaactc cataacctgt
    26641 agctctgtct cttccttcta gacctccact acctattggt tttcctgtaa ctacatgttg
    26701 attcattgaa cgttcagctg gtgcttttgt gctcatatag gtatcagcca tccacgccat
    26761 tgtttgagcg tttgtattaa catctggagc aggaatatca tgctctggtc caatattatc
    26821 tcctaatgca aacgtaaaac gtctggtaat acgctctaat tcatcttttg aatattttgc
    26881 tgggtctatt tgaattcctc ctttacctcc accgtatggt aagccagcaa gagatgtttt
    26941 ccatgtcatc cacatagcta atgctctggc tgcatcaata tctaccgttg gatggtaacg
    27001 taaacctcct ttatatggtc ccaaagcatt gttatgctgt acacgatatc cttgaaaaat
    27061 ttcaacgtct ccattatcca tctttacagg aaaattaaca ataatttcgt tattcgtaat
    27121 gcttaatatt ttacgaatat tagggtgtaa accaatttga tcagacgcac tattaaattg
    27181 ctctagtaca ttatcaacca tccctctagc attctttcgc ttcactggtt tttttaattc
    27241 cttagttaaa gtcatctcac ttatgtttga atttatgttg cttttaattt tttctgtttt
    27301 tatacagctt gcatttcttt ttctataatg actgcctgtt ttttttcttt ttttacatct
    27361 acctcattat actcactaca cgaccatacc ttttctttaa atttggttaa cacacatata
    27421 tttatctctg tacatgatgg acaaatatta aaggggttag cattcataaa ttatatttat
    27481 tttattctct ctcttaaaag caaatgatat accgttaacg atgccaaaaa aaagaaaaac
    27541 tcccaacccc ttgcaaacaa gaggctctgg aagtttttat aaatttttac ttaaaataaa
    27601 aacgggtaat ttctcctcaa atggagaaaa aacacccaga aaaatttttg ttattctttc
    27661 agcttttctc gtaatgtctt acggtctatt tgaagaattt ttgctgcttt tgttttattg
    27721 ttattagttg cgtttaatac atattgtata tgacgttttt ccatttcttt taaggggatt
    27781 aatctttcct cagaaaaatc gacattatac tttagtgaat caggtaaatg ctctacttct
    27841 actatacgat cacacataat taccgcacgc tgtattatat tttctaactc tctaatgttc
    27901 cctggccaat tatatctttg tagtatagct aaggctttag gacttatttt tatgaaccta
    27961 tctttatatt ccacaccata tttaaacaaa aacttttcta ctaacataga aatatcttct
    28021 ttcctttctc gtaaaggtgg tacctctatt tcaactactg ttaacctgta aaataaatct
    28081 tctcgaaatg ttcctttttg aatcatttct tttaaattat tgttggtagc agcaataatt
    28141 ctaacatcta ctttctctgt tttttgagct ccaaccttca ccacttcttt ttcttgtaaa
    28201 gctcttaata actttgattg tacatttaac gaagcatttc ctatttcatc taaaaaaata
    28261 gttcctccat tagccgcttg aaaaaaacca ttcctgttac tatctgctcc tgtaaaagcg
    28321 ccttttatat aaccaaacaa ctcagactct aataaatttt caggaattgc tccacagttt
    28381 accgctatgt atggtccttt agcaaatttc ccttcataat gtattgcacg agctactaac
    28441 tctttacctg ttccactttc tcctttaata gaaactgttg ctttattatt ttttactcga
    28501 tctattattt gaaaaat
//
