LOCUS       NZ_JAMTCR010000004     21131 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinokineospora globicatena strain DSM 44256
            LV79DRAFT_scaffold00003.3, whole genome shotgun sequence.
ACCESSION   NZ_JAMTCR010000004
VERSION     NZ_JAMTCR010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora globicatena
  ORGANISM  Actinokineospora globicatena
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 1057855)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1057855)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2022) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: AllPaths v. r46652
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 261.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024171945.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:43:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,731
            CDSs (total)                      :: 6,666
            Genes (coding)                    :: 6,609
            CDSs (with protein)               :: 6,609
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 49 of 57
            Pseudo Genes (internal stop)      :: 2 of 57
            Pseudo Genes (multiple problems)  :: 1 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:43:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 930334
            Orig. end                         :: 951465
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAMTCR010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21131
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21131
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21131
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11131](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11131)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    584..595
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(839..1795)
                     /locus_tag="LV79_RS23090"
                     /old_locus_tag="LV79_004544"
     CDS             complement(839..1795)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021982.5"
                     /locus_tag="LV79_RS23090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004544"
                     /product="PHB depolymerase family esterase"
                     /protein_id="WP_253840262.1"
                     /transl_table=11
                     /translation="MRSLTTALAIALCAATTAAVAQTAAAAPPHNSTIPSTGCQYTSTT
                     LPLGQSVAQTIVTSGQTRQYLIHLPTTYQPGQGKPLVLAFHGRKGDGHDIEAYSEIDAL
                     DTIAVYPIGAKGEDDERAWQGAPYAAPVDDVQFVRDLLDSVQATLCVDPYRIYAVGKSN
                     GGGFVSLLACKLPQRIAAFGVVAGAFYPGTLSACGNPTAPVPIIDFHGTADSVIAYNGD
                     SSNHGQPLPTVMSWAQSWANRSSCSPTPATAQLSSEVVGFAWGSCLPHKEVLHFKIVTG
                     DHTWPGAPVSSGPGKTTQQIKATTAIWSFLTSHPLIP"
     gene            complement(1867..4680)
                     /locus_tag="LV79_RS23095"
                     /old_locus_tag="LV79_004545"
     CDS             complement(1867..4680)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019735.5"
                     /locus_tag="LV79_RS23095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004545"
                     /product="polysaccharide lyase family 8 super-sandwich
                     domain-containing protein"
                     /protein_id="WP_253840263.1"
                     /transl_table=11
                     /translation="MAVSRRGFLVVGSAVVVALGLDMPAVAAAPYDGMRGRWRDLLTGV
                     GYDPAVAPFTAALAATGGSATRYLADMTPEGDSLWEDHPIDGDSGNVTACFTRLRTMAL
                     AWAQPGTGHTGSSTTATAVLDGLRWMLDNAYGPTGAPYDNWWDWEIGSPQRLLDICCLL
                     TVPAPDLADVLAAVDNHVPVSRLATYKDKSTGANRVDLCQVIALRGVLGARPASIAAAR
                     DGLSPVFPTVLTGDGLYADGSFLQHTCVPYAGGYGAVLLGGLAKVLHLLAGSTWAVTDP
                     NRQVLFGSVDTAFAPFIHNGLMLDAVSGRGIAREDQDDHQRGHNVMASTLLLANTGLAA
                     VAESDRWRGLVKGWITRDTHAPYLADMAVPDLARAVALLADGGVPAAAHPSSSRVFGAM
                     DRAVHRRPLWTFAVSMHSERTTFYETGNGENLRGWHTGSGMTYWWGDDYGLGQYTDAFW
                     PTVDPYRLPGATASRKSLADAAGGTWNATKPTNTWAGGASDGVAAAVGQHVTGLQSTLT
                     GRKSWFFLDDAVVCLGAGITATDGASVDSVVDNRNLGAAGTHALVVDGATQPTTLPWSK
                     KFTGARWAAIAGFGGYVFLGGATVTASRAARTGSWSAIDDSGSDDPITRRYLALWHDHG
                     TDPVDASYAYLVLPGASSVATSARSASPGVAVVANTAAVQGISAGPVRAANFFAAGACG
                     AITASGPCSVLARQDGPVLSVAVADPTRTAPTVIVTLPDNGFTAASADPGVTVLQTSPT
                     TKLLVGVGGTLGGSRTVRLGAGSPVSTGTAWAIAAAADAYVRDGGSASQNFGTGPLTVK
                     TAAAGYNRRAFVRFDLALPTAPKRAVLWLHGRVNDDDNTHSTVTAHRVTGPWTETGVTW
                     DNQPTLGSVLATARISRTPDWIGLDVTAALTANPSVITFGLSAGQFAVQLDSREATANQ
                     PVLQIVT"
     gene            4911..7598
                     /locus_tag="LV79_RS34075"
                     /old_locus_tag="LV79_004546"
     CDS             4911..7598
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.5"
                     /locus_tag="LV79_RS34075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004546"
                     /product="AAA family ATPase"
                     /protein_id="WP_285469910.1"
                     /transl_table=11
                     /translation="MVAVPPVLGRAQVIARCRSALADGGGLVLHGPAGIGKSLLLDVLV
                     AGAGADLVLRTSPAAADRDLPHVALYDLFAKVLPVVELPAHLRAALDTALLRSAPEHPV
                     DPLALRLAVVDLLRELAERHSVLLVLDDAQWLDPASAEVLAFAARRVVDNRVWVLVAER
                     ADGSPTTADLAPSPVTEVELTGIDADAVAELLRTRLVRPLSSATVGRVVAASAGNPFYA
                     LELGRALARHGGSVGADEPLPVPGKLRELVVDRLAPLPAQAWDVLRLVTVAVRPGLDLL
                     PLGDPGLDAAVAAGVLVADEDGALRFSHALVAEVVAAEATAAQWTAAHARMAALVTDPI
                     ERARHRALATPRPDAPIAAELVEAARLATTRGAPATAADLLRLAAHRTPAPSIRAERLL
                     GAARAAAEAGLTASAADLCRAVVRIAVGPTRAWARLLLFDLAGRDIVAFAGLLDEVAAD
                     AGDDPGLRCALLLRRAELAAHTGRTTEALAYLDQADVLAPRADDPTLVIRSLIMRIPFA
                     AASGPDTETDLCRRLTRHTAGLPLSEPVVYARVYLAIICLRRGDTPEAVDMLERLRHET
                     EAAGRIRDLIMVLYSLTSAYERAGRCADARRTAVRGARLRVDVDQNPGIGLTLRAVAEL
                     NTGSLDEATTLLAQAEKADEQARDGEWAAYASGLRARVAVLRGEHRAAARLFGSCLATL
                     REVGYTDPAMFLVDADLAESLAWAGQSDQADAVLRDARSRVAAQGRPVVTLGLDRATAV
                     LAATAGDPRGAADTLRAHLPPTHPYPLELARAWFTLGTLERRARRKAAAREAMTESLRR
                     YTTASCTPWIDRIETELSKLDTQDAPLTPLETQIVDHLHQGASNRQIATALHLSVKAVE
                     ANLTRIYRKLGIRNRAELTPTPPA"
     gene            complement(8219..9904)
                     /locus_tag="LV79_RS23110"
                     /old_locus_tag="LV79_004547"
     CDS             complement(8219..9904)
                     /EC_number="2.7.7.65"
                     /EC_number="3.1.4.52"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071111 - cyclic-guanylate-specific
                     phosphodiesterase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680680.1"
                     /locus_tag="LV79_RS23110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004547"
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="WP_253840264.1"
                     /transl_table=11
                     /translation="MTVAPDVSFAFQPLLSTRTGEAIAVEALARPRTGDTYDLLRAAGK
                     AGRLVQTDISLASRAVLASVRQDPPLPLHVNIVAATATAPDELLRFLRPALNQTGRKPR
                     DIVLEITPPFSRVHRAELIRGLAVLREAGYGVAFDAIGDGDLPLSLLTDVGPDLIKLDA
                     HLIAGLPDDPACLAVVECLAQYCTRTGTRLAAVGVESEEQLLCLNRLGVRLAQGNLLAG
                     ASQEGGISLPLPRPVAEIIELNATTGAAPVPVVSDYLRPATTMAQDATSEEVRDTFADN
                     PAISGVVLVDAEGRPVSTLPRSRFLLAVTGLYGHALNAKKPAVRHGDIPRTIRGDASSL
                     QLLDLVGDTDWDRHGDEVVVVDADRVCVGVARISEVVRGVAEAKIEQAAALNPLTRLPG
                     SDTVDRDIDRRIHAAEMFVVAWLDVDSFKQVNDTVGFAAGDDLIRHIGRVLADAERDLN
                     GTRVAHVGGDDFLVVTDLDEISALAARLVDRQWDAEGMSVSVSLASLVCAAGSVRSYRE
                     ASRLLAPLKKRAKSVPGSSWVLSRPGSDRVEVLRGSRPAHARVG"
     gene            complement(10001..11131)
                     /locus_tag="LV79_RS23115"
                     /old_locus_tag="LV79_004548"
     CDS             complement(10001..11131)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672751.1"
                     /locus_tag="LV79_RS23115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004548"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_308208959.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 2.3e-38, bitscore:
                     128.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-07, bitscore:
                     27.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLDVVVVGGGPAGWAVADACARAGLTTAVVAPGGRRVWPATFG
                     VWADQVPADRYPGVLATRVLAAGRVIDREYLVLDNAAVCARLWRGPAVSVDDEVVGAEF
                     GRRGATVRLGSGRRLACAVVIDASGARRVVSGGPAPGVRVAQTAYGVVVPSAVADGIVR
                     SGDAVLMDWGRPPTFLYAVGVSADRVLLEETSLAARPGTGWDELRRRLGERLGSVPDGP
                     VERVRFPVDLPPTPPWHRGSVPFGAAAGMVHPATGYSVGDALATAPLVAAAIASAFGRG
                     PVAAAAAGRAAVWSPRARVVHAMRSHGLRALLALPPEGLAEFFDVFFALSPRLQRAYLS
                     GREDVAGTAAAMAAVFGASRWGIRGKLLLSRHSPPG"
     gene            11289..12839
                     /locus_tag="LV79_RS23120"
                     /old_locus_tag="LV79_004549"
     CDS             11289..12839
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003071249.1"
                     /locus_tag="LV79_RS23120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004549"
                     /product="deoxyguanosinetriphosphate triphosphohydrolase
                     family protein"
                     /protein_id="WP_253840265.1"
                     /transl_table=11
                     /translation="MSDLHERRVERRDGRGGTDLTANPFRADRDRIVASPFFARLGGVT
                     QVVSASGSGLLHNRLTHSLKVAQIGRAIAERLTADPDHAALIDRLGGCDPDVVEAAALA
                     HDLGHPPFGHLGEQVLDRLARHRFGLPDGFEGNAQSFRIITTTDTRGPSAAGLDLTAAV
                     RAATLKYPWTRLSHPDPHPRDLPDPPRGAAQPPEGPGTGSSKFSAYVTELDDLRQARAV
                     FDDLVPPWQQTVEASVMDNADDIAYAIHDLEDFHRIGVLQHAPVSAELGQWEADRAEFA
                     RLDDAELASGRRPGQSLERLRRRLHARDSWVVDDEAFAAAVSRVRAELVDDLLSMPFDG
                     SVAAEQAFGRFSSGWTARLVAGVHVVADPPTRSGHVLLGPRQWHEVQVLKFVHRRFVLL
                     RPDLALHQRGQARLLTTLVEALDQWLGDRYEADRLPRRLHDLVELARVEYDWLAAEHPR
                     ALVGATGEGPEGQAGVLALARGRAVIDFAASLADGQAATLLEALSGRTGQFWSDAFVL"
     misc_feature    complement(12859..12875)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.09"
                     /tool="antismash"
     gene            13100..15868
                     /locus_tag="LV79_RS23125"
                     /old_locus_tag="LV79_004550"
     CDS             13100..15868
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003071246.1"
                     /locus_tag="LV79_RS23125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004550"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_253840430.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.2e-15, bitscore:
                     51.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPASAQALPAGPLAAQENSARQIAALQRLKQTQTKAESKLDSK
                     LAVESRVRRDRSAAAATPYLQSGVKVSATGTVLVDISVEEVTDDLLGALTKSGAGIRAV
                     SAGLGEIRAEVPFAALTGISGRADVRKVETASGAITASAKRDKAPATKETKEQKEARVA
                     ASVQSALEQRGTAALVTSEGDRAHNADTARAEYGVTGVGVKICALSDGVDSLAASQAAG
                     ELPAVDVLPTQEGEGDEGTAMLEILHDLAPGAALGFASAFNSEASFADNIRALRQQLRC
                     DIIVDDVLYFVESPFQDGLIARAVNDVTADGALYFSSAGNEGNTVDGTAGHWEGDFRDS
                     GRIVGKFAGTAHDWDPSATTQVFQPISTASSAQVPVTLHWADPLGASANDYDLYLFDRN
                     GNVVTFSQDVQDGEQDPYEILQTPTFGGTGLRLAVVKFYGENRYFSLSALRGRFSDSAD
                     GLKAFNTPGVTVGHSAAKQAFSVAAAPAAGPLPFDLEPGDPANPRGPHPGSFSATSPLE
                     RFSSDGPRRVFYKADGTPITPGNFGATGGEVRAKPDITAADGVLTSVDGFDPFFGTSAA
                     APHAAAIAGLVLSGNPGIAQAEVREALVNTAIDLGPAGFDGRTGAGIILADRVLAYTGA
                     SPQPRALAQNPTIAPTDGGDLVDPGDTVSVTLPVRNTGDADAVSTSVVLTSPTAGVTIA
                     PRSQNYGTVQKGQTVSKVYTVTVPLSHPVGTPVVLDARVTFAAAASPTKATFTFSVGRP
                     SPTVQDFAYGGAPVAVPDNNPLGASVTIPVSGVGRASRVSFSVDGATCSTATGATTVGL
                     DHTFVGDLVGTLTAPNGAVATIHSRSGGGGNNFCKVVFADSATAAFSSVTSANAPFTGS
                     WRPTTPLTGFAAVIADGTWTYKVVDAAGGDTGSIRAVSLHINGYLTPPPAG"
     gene            15964..16635
                     /locus_tag="LV79_RS23130"
                     /old_locus_tag="LV79_004551"
     CDS             15964..16635
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016699278.1"
                     /locus_tag="LV79_RS23130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004551"
                     /product="acVLRF1 family peptidyl-tRNA hydrolase"
                     /protein_id="WP_253840266.1"
                     /transl_table=11
                     /translation="MGRTRDVAGGGRAVEVPVERVPGWFTRFGDRHRGVTHTSLSAGSV
                     VCTATDGATASVVVPFPPLAVVGERDGLEVGPLLDHLAVSRRVGLVLVRLGGHSLGIAE
                     PGRVLVSRTDRHLVHGRSAAGGWSQQRFARRREGQARHALEAAARDIAEVLVPRVGELD
                     AVVLGGDRQSLDVLRADRGLAPVFDLAIDRVLDVPEPRRTVLEDAVERAFALEIVVRDR
                     P"
     gene            16680..17066
                     /locus_tag="LV79_RS23135"
                     /old_locus_tag="LV79_004552"
     CDS             16680..17066
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LV79_RS23135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LV79_004552"
                     /product="hypothetical protein"
                     /protein_id="WP_253840267.1"
                     /transl_table=11
                     /translation="MSTTPPDPAPAVEPTPEPARTEAPPVAQSPAASVVEAPPRTVSLL
                     VAGLAGVVLLLVGGIAGYAIGNSGGHDRPAPGVSRHGGPGPHARPDFPHPPRPGGQGRR
                     PNTPPAPTPSSATPTSAPAATPSS"
     gene            complement(17152..17919)
                     /locus_tag="LV79_RS23140"
                     /old_locus_tag="LV79_004553"
     CDS             complement(17152..17919)
                     /NRPS_PKS="Domain: PKS_KR (10-177). E-value: 1.6e-07.
                     Score: 23.4. Matches aSDomain:
                     nrpspksdomains_LV79_RS23140_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803842.1"
                     /locus_tag="LV79_RS23140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004553"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_253840268.1"
                     /sec_met_domain="adh_short_C2 (E-value: 2.8e-36, bitscore:
                     121.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTAEYAGRAALVTGASRGIGLAIATELARRGAAVAISSRKQDDL
                     DAAAASITAAAPGARVLAVAGNTGVDADRERVVARTVDELGGLDVLVNNTGINPVYGPL
                     VDVDLDGVRKIFDTNVVAALGFVQLAYHSWMAAHGGVVINIASVAGLRSSGVIAAYGAS
                     KAALVRLTEELAWQLGPGIRVNAVAPAVVKTRFATALYADREEEASAPYPMKRLGTPED
                     VADLVAFLCSDQASWITGETVRVDGGLLATGTL"
     aSDomain        complement(17389..17889)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LV79_RS23140_PKS_KR.1"
                     /evalue="1.60E-07"
                     /label="LV79_RS23140_PKS_KR.1"
                     /locus_tag="LV79_RS23140"
                     /protein_end="177"
                     /protein_start="10"
                     /score="23.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGASRGIGLAIATELARRGAAVAISSRKQDDLDAAAASITAA
                     APGARVLAVAGNTGVDADRERVVARTVDELGGLDVLVNNTGINPVYGPLVDVDLDGVRK
                     IFDTNVVAALGFVQLAYHSWMAAHGGVVINIASVAGLRSSGVIAAYGASKAALVRLTEE
                     LAWQ"
     CDS_motif       complement(17800..17886)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LV79_RS23140_0001"
                     /evalue="2.10E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="LV79_RS23140"
                     /protein_end="40"
                     /protein_start="11"
                     /score="23.6"
                     /tool="antismash"
                     /translation="LVTGASRGIGLAIATELARRGAAVAISSR"
     gene            18103..19731
                     /locus_tag="LV79_RS23145"
                     /old_locus_tag="LV79_004554"
     CDS             18103..19731
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645324.1"
                     /locus_tag="LV79_RS23145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004554"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_253840269.1"
                     /transl_table=11
                     /translation="MITATDLELRAGSRILLADASLRVQAGDRIGLVGRNGAGKTTTLR
                     VLAGEGEPYGGDLRRTGELGYLPQDPREGDLSVTAKDRVLSARGLDELLREMEKAQTAM
                     AEHADDSVRDNAVRKYGRLEERFSALGGYAAESEAARICSNLGLADRILAQPLRTLSGG
                     QRRRVELARILFAASEAGAGGGAGTILLLDEPTNHLDADSITWLRGFLKGHSGGLVVIS
                     HDVELLGDVVNKVWFLDAMRGEVDTYNMGWKRYLDARAADEKRRRRERANAEKKAGVLM
                     EQANKMRAKATKAVAAQNMIKRAEKLVSGLDDVRQSDKVAKIRFPEPAPCGKTPLLAEG
                     LSKSYGSLEIFTGVDLAIDKGSRVVILGLNGAGKTTLLRLLGAMETPDSGEVIAGHGLR
                     LGYYAQEHETLDHSASVWANIRHAAPDTGEQQLRSLLGTFLFTGEQLDQPAGTLSGGEK
                     TRLALAGLVSSAANVLLLDEPTNNLDPASREQVLDALRRYSGAVVLVTHDPGAVEALEP
                     ERVILLPDGSEDHWSAEYLELVQLA"
     gene            19919..20128
                     /locus_tag="LV79_RS23150"
                     /old_locus_tag="LV79_004555"
     CDS             19919..20128
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003071237.1"
                     /locus_tag="LV79_RS23150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004555"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_092780245.1"
                     /transl_table=11
                     /translation="MADLKKGARITGALRDKLATDLKKKYEKGASIRALAESTGRSYGF
                     VHRVLSESGVTLRGRGGATRTKKK"
     misc_feature    complement(20525..20539)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    20669..20684
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    21089..21104
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
ORIGIN
        1 gcatcggccg ggacaaggcc gcggcggtgt tctaccgcgc gctgagcacg tacatgacct
       61 cgacgaccaa ctacgccggg gcgcgcaccg cgaccctgca ggccgccgcc gacctgtacg
      121 gcaccaacag ccaggagcgc tacctggtca gcgtcgcctg ggccgccgtc agcgtcggca
      181 ccgccctccc ggcgccgacc acgaccacca cccgcccgac cacgacgacc agccccaccg
      241 gtccgaccac gaccacccgg cccacgacgt ccgtgccgac cacgacgacg gtcccgccga
      301 ccggcaacgc ggtcaccaac ggcggcttcg agtccggcca gaccgggtgg agcgagtccg
      361 ctgtggtcac caacagcacc cagcagaccg cgcgcagcgg ttcgtactac gcgtggctgc
      421 tcggcaacgg cagggccgcc agtgaggcca tcagccagca ggtcagggtg cccagcaccg
      481 gcgcgcccgc gctccggttc tggctgaagg tcaccacgca ggagaccggc agcaccgcct
      541 acgacgtgct gcgcgtccaa ctcaacggca ccacggcggt cacgtactcg aacgccaacg
      601 cgggcaccgc ctacgtccaa cgcgcggtgg acctctcggc gtaccggggc cagaccgtca
      661 cgatccgctt ctccggcgtg gaggacgcct acctcgcgac caacttcctc ctcgacgacg
      721 tcagcgtcgg ctgacccgtc cgcaagcctc ctccccggcg tgtttggccc ccgccgggga
      781 ggagcccgac ctcggcgacc caggaccact gcgctgggtc gccgaggtca ccgccgtcct
      841 aggggatgag cgggtggctg gtcaggaagc tccagatcgc ggtggtcgcc ttgatctgct
      901 gggtcgtctt gcccggcccg ctcgacaccg gcgcacccgg ccaggtgtgg tccccggtaa
      961 cgatcttgaa gtgcagcacc tccttgtgcg gcaggcacga accccaggcg aacccgacga
     1021 cctcgctgct gagctgggcc gtcgcgggcg tgggcgagca cgagctgcgg ttggcccagg
     1081 actgcgccca actcatgacc gtgggcagcg gttggccgtg gttgctgctg tcgccgttgt
     1141 acgcgatgac ggagtccgcg gtgccgtgga agtcgatgat cggcaccggc gcggtcgggt
     1201 taccgcaggc ggagagggtg cccgggtaga aggcccccgc gacgaccccg aacgccgcga
     1261 tgcgttgggg gagcttgcaa gcgagcaggg acacgaaccc gccaccgttg gacttgccca
     1321 cggcgtagat ccggtacggg tcgacgcaca gggtggcctg caccgagtcg agcagatccc
     1381 tgacgaactg cacgtcgtcc accggcgccg cgtagggcgc cccctgccag gcccgctcgt
     1441 cgtcctcccc cttggccccg atcgggtaca ccgcgatggt gtcgagcgcg tcgatctccg
     1501 agtaggcctc gatgtcgtgg ccgtccccct tgcgcccgtg gaacgccaac accagcggct
     1561 tgccctgtcc cggctggtag gtcgtgggca ggtggatcag gtactggcgg gtctggccac
     1621 tggtcacgat cgtctgcgcc acggactggc cgagggggag tgtggtcgag gtgtactggc
     1681 accccgtcga ggggatggtg gagttgtgcg gaggggcggc ggccgctgtc tgtgcgacgg
     1741 ccgccgtggt ggccgcgcag agcgcgatgg cgagcgcggt ggtgagtgat ctcatggcac
     1801 ctcaatgggt tggcgagtgc ggtggacgtc cccggccggg gatcgtcccg ataggactga
     1861 gtgcggtcag gtcacgatct gcagcaccgg ctggttcgcg gtggcctccc ggctgtccag
     1921 ctggaccgcg aactggcccg ccgacagccc gaacgtgatg acgctcgggt tcgcggtcaa
     1981 cgcggccgtg acgtccagcc cgatccagtc cggtgtgcgg ctgatccggg cggtggccag
     2041 caccgacccc agggtgggct ggttgtccca cgtcacgccg gtctccgtcc acggcccggt
     2101 cacccggtgc gcggtcaccg tggagtgggt gttgtcgtcg tcgttgaccc tgccgtgcaa
     2161 ccacagcacg gctcgcttcg gcgcggtggg cagggcgagg tcgaaccgga cgaacgcgcg
     2221 tcggttgtac ccggccgccg ctgtcttgac agtgagcggc ccggtgccga agttctggct
     2281 cgcggagcca ccgtcgcgca cgtaggcgtc ggcggccgcg gcgatggccc atgccgtgcc
     2341 ggtcgacacc ggcgaacccg cgccgagtcg gaccgtgcga ctgccgccga gcgtgccacc
     2401 gaccccaacc aggagctttg tggtcggcga tgtctgcagc acggtcaccc cgggatccgc
     2461 cgaggccgcg gtgaaaccgt tgtcgggcaa ggtgacgatc accgttggtg ccgtccgggt
     2521 cgggtcggcg acggccaccg acagcaccgg cccgtcctgg cgggccaaca ccgagcacgg
     2581 cccgctcgcg gtgatcgccc cgcacgcgcc cgccgcgaag aagttcgccg cgcgcaccgg
     2641 tcctgccgag atcccttgta cagcggccgt gttcgccacc acggccacgc caggtgacgc
     2701 gctgcgagcg gacgtggcaa cgctcgacgc gccaggcagg accaggtagg cgtaggaggc
     2761 gtcaacagga tcggtgccgt ggtcgtgcca cagcgcgagg tagcggcggg tgatcgggtc
     2821 gtccgagccg ctgtcgtcga tggcgctcca ggaaccggtg cgcgccgcgc gggacgcggt
     2881 gacggtcgcc ccaccgagga acacgtaccc gccgaacccg gcgatcgccg cccaccgcgc
     2941 cccggtgaac ttcttcgacc agggcagcgt cgtcggttgg gtcgcgccgt ccacgaccag
     3001 cgcgtgcgtg cccgccgcgc cgaggttccg gttgtccaca acggagtcga cggacgcgcc
     3061 gtcggtcgcg gtgatgcccg cgccgaggca caccacggca tcgtcgagga agaaccacga
     3121 cttgcggccg gtgagggtcg actgcaaccc ggtcacgtgc tggccgaccg cggccgcgac
     3181 gccgtcactg gcgccgcccg cccaggtgtt ggtcggcttg gtcgcgttcc acgtgccgcc
     3241 cgccgcgtcg gccagcgact tgcgcgaggc ggtcgcacct ggcaaccggt aggggtcgac
     3301 cgtcggccag aacgcgtcgg tgtactgacc gaggccgtag tcgtcgcccc accagtaggt
     3361 catgccgctg cccgtgtgcc agccgcgcag gttctcgccg ttgccggtct cgtagaacgt
     3421 ggtgcgctcg gagtgcatcg acaccgcgaa ggtccacagc ggacgccggt gcacggcgcg
     3481 gtccatcgcc ccgaagaccc ggctcgacga cgggtgcgcc gcggcgggca caccgccgtc
     3541 ggcgagcagc gccaccgcgc gcgccaggtc cggtaccgcc atgtcggcca ggtacggcgc
     3601 gtgggtgtcg cgggtgatcc agcccttcac cagaccgcgc caccggtccg actcggccac
     3661 cgcggccaac ccggtgttcg ccagcagcag ggtcgacgcc atgacgttgt gcccgcgctg
     3721 gtggtcgtcc tggtcctcgc gggcgatgcc gcgtcccgag accgcgtcca gcatgagtcc
     3781 gttgtggatg aacggggcga acgccgtgtc caccgagccg aacagcacct gccggttcgg
     3841 gtcggtcacc gcccaggtcg agcccgcgag caggtgcagc accttggcca ggccaccgag
     3901 cagcacggcg ccgtagccgc ccgcgtaggg cacgcaggtg tgctggagga acgagccgtc
     3961 cgcgtagagc ccgtcgccgg tgaggaccgt cgggaacacc ggggacagcc cgtcgcgggc
     4021 ggcggcgatg ctcgcgggtc gcgcgccgag caccccgcgc agcgcgatca cctggcacag
     4081 gtccacccgg ttcgcgccgg tgctcttgtc cttgtaggtc gccaggcgcg agaccgggac
     4141 gtggttgtcc accgcggcga ggacgtccgc caggtccggg gcgggcacgg tgagcaggca
     4201 gcagatgtcg agcagccgct gcggggaccc gatctcccag tcccaccagt tgtcgtacgg
     4261 cgccccggtc gggccgtacg cgttgtccag catccaccgc agcccgtcga gcaccgccgt
     4321 cgccgtcgtc gacgagccgg tgtggcccgt gcccggctgc gcccaggcca gtgccatcgt
     4381 gcgcaaccgg gtgaagcagg cggtcacgtt gcccgagtcc ccgtcgatcg ggtggtcttc
     4441 ccagagtgag tccccctcgg gggtcatgtc ggccaggtac ctcgtcgccg aaccgccggt
     4501 cgccgccaac gcggccgtga acggggcgac cgccgggtcg tacccgacac cggtgagcag
     4561 gtcgcgccac cggccccgca tcccgtcgta cggtgcggcc gccaccgcgg gcatgtcgag
     4621 ccccaacgcg acgaccaccg ccgaccccac caccaggaac ccccgtcggg acaccgccat
     4681 gcgctccgcc tcaccgctgg tccgccgcgc tgatgatcaa cgcctgccgc ggctgacacg
     4741 cggggtcccc cgtcccgcgt tgcacgggca taaggatctt ctcgggtgcc atcacccact
     4801 cctcggtctt gggcgtccgc tggtccggga gcccgggtgc gctgtcccac ttccgccgat
     4861 gacgtagttc ggtctcgccg ggatcgggag tggttgggta cgttcactgg gtggtggccg
     4921 tccccccggt gctgggccgg gcgcaggtga tcgcccgctg tcggagcgcg ctcgccgacg
     4981 ggggcggtct ggtgctgcac gggcccgccg ggatcggcaa gtccctgctg ctcgacgtgc
     5041 tcgtcgccgg ggccggggcc gacctggtgc tgcggaccag cccggccgcc gctgaccgcg
     5101 acctgccgca cgtcgcgctc tacgacctgt tcgccaaggt gctgccggtc gtcgagctgc
     5161 ccgcccacct ccgggccgcc ctggacaccg cactcttgcg atccgccccc gaacatcccg
     5221 tcgacccgct cgcgttgcgc ttggccgtgg tcgacttgct ccgcgaactg gccgagcggc
     5281 actcggtgct gctcgtgctc gacgacgcgc aatggctcga cccggccagc gccgaggtgc
     5341 tggccttcgc cgcccgccgg gtggtcgaca accgggtctg ggtgctggtc gccgagcgcg
     5401 ccgacgggtc gccgacgacc gcggacctgg ccccgtcccc ggtgaccgag gtggagctga
     5461 ccggcatcga cgccgacgct gtcgccgagc tcctgcgcac caggctcgtc cggccgctgt
     5521 cgtcggccac cgtcggccgg gtggtcgccg ccagcgcggg caacccgttc tacgcgctcg
     5581 aactgggccg cgcgctggcc aggcacggcg gctcggtcgg cgcggacgaa ccgctgccgg
     5641 tgccgggcaa gctgcgcgaa ctggtggtcg accgactcgc accgttgccc gcgcaggcct
     5701 gggacgtgct gcgattggtg actgttgcgg tccggccggg gctggacctg ctgccgctgg
     5761 gcgaccccgg tctcgacgcc gccgtcgccg ccggggtgct ggtcgccgac gaggacgggg
     5821 cgctgcggtt cagccacgcg ctggtggccg aggtggtcgc cgccgaggcc accgccgcgc
     5881 agtggaccgc cgcgcacgcc aggatggcgg ccctggtcac cgacccgatc gaacgcgccc
     5941 gccaccgcgc gttggccacc ccccgtccgg acgcgccgat cgccgccgaa ctggtggagg
     6001 cggcccggct ggccaccacc cggggcgcgc ccgccaccgc cgccgacctg ctgcgactcg
     6061 ccgcgcaccg cacacccgcg cccagcatcc gcgccgaacg cctgctcggt gccgcccgcg
     6121 ccgccgccga ggccgggttg accgcgtccg ccgccgacct gtgccgtgcc gtcgtgcgca
     6181 tcgccgtcgg accgaccagg gcatgggccc ggctgctgct gttcgacctc gccgggcgcg
     6241 acatcgtggc cttcgccggg ttgctcgacg aggtcgccgc cgatgcggga gatgaccccg
     6301 ggttgcgctg cgcgttgctg ttgcgccgcg ccgaactcgc cgcccacacc ggccgcacca
     6361 ccgaggcgtt ggcgtacctc gaccaggccg acgtgctcgc cccccgcgcc gacgacccga
     6421 ccctggtcat ccggtcgctc atcatgcgca tcccgttcgc cgccgcgtcc ggaccggaca
     6481 ccgagaccga cctgtgcagg cggctgaccc ggcacaccgc gggcctgccg ctgtccgaac
     6541 cggtggtcta cgcccgcgtc tacctcgcca tcatctgcct gcgccgcggc gacacccccg
     6601 aggccgtcga catgctcgaa cgcctgcgcc acgaaaccga ggcggcgggc cgcatccgcg
     6661 acctgatcat ggtcctgtac tcgctgacct ccgcctacga acgcgcgggc cgctgcgctg
     6721 acgcccgccg caccgccgtc cggggggccc gcctgcgcgt cgacgtcgac cagaaccccg
     6781 gcatcggcct gaccctgcgc gccgtcgccg agctcaacac cggcagcctc gacgaggcga
     6841 caaccctgtt ggcccaggcg gaaaaggccg acgaacaggc cagggacggg gagtgggcgg
     6901 cgtacgcgag cggcctgcgc gcccgggtcg ccgtgctgcg cggcgagcat cgtgccgccg
     6961 cccggctgtt cggcagctgc ttggcgacac tgcgcgaggt cggctacacg gacccggcaa
     7021 tgttccttgt ggacgctgac ttggcggaat cccttgcctg ggcaggacaa tccgaccagg
     7081 ctgacgcggt gttgcgggac gcgcgctccc gggtcgctgc ccagggcagg cccgtcgtca
     7141 ccctaggtct agaccgcgcc accgccgtcc tagccgccac cgcaggcgac ccccgaggcg
     7201 ccgccgacac cctccgcgcc cacctccccc caacccaccc ctacccccta gaactagccc
     7261 gcgcctggtt caccctcggc accctggaac gccgcgcccg ccgcaaagcc gccgctcgag
     7321 aagccatgac cgagtccctc cgccgctaca ccaccgccag ctgcaccccc tggatcgacc
     7381 gcatagaaac cgaactgtcc aaactagaca cccaagacgc ccccctcacc cccctcgaaa
     7441 cccagatcgt cgaccacctc caccaaggcg ccagcaaccg ccagatcgcc accgcactcc
     7501 acctctcggt caaggccgtg gaagccaacc tcacccgcat ctaccgcaaa ctaggcatcc
     7561 gcaaccgcgc cgaactaacc cccaccccac ccgcctaacg ccgcccgcca cccctccccg
     7621 ccaagccccc acgccagtcc cagcccaccc gtcacgactg gcgaagaccc cacaacgttg
     7681 gcccccaacc gcccgccgac accgttggcc cgacacgccc gccgacaacg ttggccgccc
     7741 cgcgctccac ccgagtcgct ggtgccaggc tggctcgatg gggtggactt gttttgtgtg
     7801 ggggaggacc acccgtagcg tcgttgcgcg gacagggcca tgcttttggg cccctgcttt
     7861 gcggtcctgc cacgggtggt tcaggggccc cgcgcaaaac aagttcgccc catcgagcaa
     7921 agctcgaaac tcgcgtcaat ccgatggcgc agccgaggcg tttcccgcag cgcagcggag
     7981 gccacgaaag ccggagatcc ccagctcaac gcactgccgc ccacggccgc caagatcaac
     8041 ccgccccaaa gacccccgaa tacacagcct accgaggggt acgcgagcgc ggagaggctg
     8101 aaagtcgacc ctgtggacaa ccaggaccca tgtggacaac ccccacccgg ccccccgcca
     8161 cccaaagcca gacaagagcg agagcgctag acccgaactc gcccaaaccc caaatggact
     8221 acccgacgcg ggcgtgggcg gggcgggagc cgcggaggac ctccactcgg tcgctgcccg
     8281 gccggctcaa cacccagcta gagccaggaa cggacttggc ccgcttcttg agcggtgcca
     8341 acaaccgcga agcctcccgg taggaccgca ccgaccccgc cgcgcacacc aacgatgcca
     8401 gcgagacgct cacggacatg ccctccgcat cccactggcg gtcgaccagg cgggcggcga
     8461 gggcgctgat ctcgtcgagg tcggtgacga ccaggaagtc gtcgccgccg acgtgggcta
     8521 ctcgggtgcc gttgaggtcg cgttcggcgt cggcgaggac tcggccgatg tggcggatga
     8581 ggtcgtcgcc cgcggcgaag ccgacggtgt cgttgacctg cttgaaggag tcgacgtcga
     8641 gccaggcgac gacgaacatc tcggcggcgt ggatgcggcg gtcgatgtcg cggtcgacgg
     8701 tgtcgctgcc ggggagccgg gtcagcgggt tgagcgccgc ggcctgttcg atcttggcct
     8761 cggcgacgcc gcgcacgacc tcggagatgc gggccacgcc gacgcacacc cggtccgcgt
     8821 cgaccaccac gacctcgtcg ccgtgccggt cccagtcggt gtcgcccacc aggtccagca
     8881 gctgcaggct gctggcgtcg ccgcggatgg tgcgggggat gtcgccgtgg cgcacggcgg
     8941 gcttcttggc gttgagcgcg tgcccgtaca ggccggtgac cgcgagcagg aaccggctgc
     9001 gcggcagcgt gctcaccggc ctgccctccg cgtcgaccag caccacgccg ctgatcgccg
     9061 ggttgtcggc gaaggtgtcg cggacctcct cggaggtcgc gtcctgggcc atcgtggtcg
     9121 cgggccgcag gtagtccgac accaccggta ccggtgcggc ccccgtggtc gcgttcagct
     9181 cgatgatctc ggcgaccggg cgcggcagcg gcagcgagat gccgccctcc tggctggcgc
     9241 ccgcgagcag gttgccctgc gcgagccgca ccccgagccg gttgaggcac agcaactgct
     9301 cctcggactc gacgccgacg gccgcgagcc gggtgccggt gcgggtgcag tactgcgcca
     9361 ggcactcgac gacggccagg cacgccgggt cgtcgggcag ccccgcgatc aggtgcgcgt
     9421 ccagcttgat caggtcgggg ccgacgtcgg tgagcagcga cagcggcagg tcgccgtcgc
     9481 cgatggcgtc gaaggcgacc ccgtagcccg cctcgcgcag caccgcgagg ccgcggatca
     9541 gctcggcgcg gtgcacccgg ctgaacggcg gggtgatctc cagcacgatg tcgcgcggct
     9601 tgcgcccggt ctggttcagc gcggggcgca ggaaccgcag cagctcgtcc ggcgcggtcg
     9661 cggtcgcggc gacgatgttg acgtgcagcg gcagcggcgg gtcctgccgg acggaggcga
     9721 gcaccgcccg gctggccagg gagatgtcgg tctgcacgag cctgcccgcc ttgcccgcgg
     9781 cgcgcagcag gtcgtaggtg tcaccggtgc gcggtcgggc cagggcctcc acggctatgg
     9841 cctcaccggt acgggtgctg agcagcggct ggaacgcgaa gctgacgtcc ggtgcgacgg
     9901 tcaccctgac atcgtgcccg gcgaccgccg tcaggtgatg gttagtcacc atctgttcat
     9961 cgagctgtgc ccggaagcac caaccagcgc cgagcgcccg tcaccctggt ggggaatggc
    10021 gcgatagcag cagtttcccg cgaattcccc accgggacgc gccgaacacc gccgccatcg
    10081 ccgccgccgt ccccgccacg tcctcccgtc cgctcaggta cgcgcgctgg agccgcgggg
    10141 acaacgcgaa gaagacgtcg aagaactcgg cgagcccttc cggcggcagt gccagcagag
    10201 cccgcaaccc gtgcgaccgc atcgcgtgca cgacccgagc ccggggtgac cacaccgcgg
    10261 cccgccccgc cgctgccgcc gcgaccggac cccgcccgaa cgcgctcgcg atcgccgccg
    10321 ccacgagcgg ggccgtggcc agcgcgtcgc ccacgctgta gccggtcgcc gggtgcacca
    10381 tcccggccgc cgcgccgaac ggcaccgacc cgcggtgcca cggcggcgtc gggggcaggt
    10441 cgaccgggaa ccggacccgc tccaccggcc cgtccggcac cgaccccagc cgctcgccga
    10501 gcctgcgccg caactcgtcc caccccgtgc cgggccgggc cgccagcgac gtctcctcca
    10561 gcaacacccg gtcggccgac accccgacgg cgtagaggaa cgtcggcggc ctgccccagt
    10621 ccatcagcac cgcgtcaccc gaacggacaa tcccgtcggc gacggccgaa ggcaccacga
    10681 ccccgtacgc cgtctgcgcc acgcggaccc ccggggccgg gccgccggac accacccgcc
    10741 gcgcaccgct cgcgtcgatg accaccgcgc acgccaaccg ccgccccgac cccagccgca
    10801 ccgtcgcgcc ccggcggccg aactccgcgc ccaccacctc gtcgtcgacc gacaccgcgg
    10861 gcccgcgcca cagccgcgcg cacaccgccg cgttgtccag caccaggtac tcccggtcga
    10921 tcacccgccc cgccgccagc acccgcgtcg ccagcacacc cgggtaccgg tccgctggga
    10981 cctggtcggc ccacacgccg aacgtcgccg gccacacccg tcgcccgccc ggcgcgacca
    11041 ccgcggtcgt cagccccgct cgcgcgcagg cgtccgcgac cgcccacccc gccgggccac
    11101 caccgaccac gaccacgtcc aaccggctca ccccctctcg ctaccacgcc ccgccccacc
    11161 acgacagtcc gacctctggc cgcggccgga aaaccccagt actgccggct tcccacccaa
    11221 gcacccggga acgtgtggat cacgactccc acccgccagc cccccgggac tgcacctagg
    11281 ctcgcggcat gtcggatctc cacgagcgcc gggtcgagcg ccgcgacggc cggggcggca
    11341 cggacctcac cgccaacccg ttccgcgccg accgcgaccg gatcgtcgcc tcgccgttct
    11401 tcgcgcggct cggcggggtc acccaggtgg tcagcgccag cggctccggg ttgctgcaca
    11461 accggctcac gcacagcctc aaggtcgccc agatcggccg cgccatcgcc gagcggctca
    11521 ccgccgaccc cgaccacgcg gcgctgatcg accggctcgg cggctgcgac cccgacgtgg
    11581 tggaggccgc cgcgctcgcc cacgacctcg gccacccgcc gttcggccac ctcggcgaac
    11641 aggtgctcga ccggctcgcc cggcaccgct tcggcctgcc cgacgggttc gagggcaacg
    11701 cgcagagctt ccggatcatc accaccaccg acaccagggg accgtccgcc gccgggctcg
    11761 acctcaccgc cgccgtgcgc gccgcgaccc tcaagtaccc gtggacccgg ctctcgcacc
    11821 ccgacccgca cccgcgcgac ctgcccgacc cgccgcgcgg cgccgcgcag ccacctgagg
    11881 gccccggcac cgggtcgagc aagttctccg cctacgtcac cgagctcgac gacctgcgcc
    11941 aggcccgcgc ggtgttcgac gacctggtgc cgccgtggca gcagaccgtc gaggcgtccg
    12001 tgatggacaa cgccgacgac atcgcctacg ccatccacga cctggaggac ttccaccgca
    12061 tcggggtgct gcagcacgcg ccggtgtcgg cggagctggg ccagtgggag gccgaccgcg
    12121 ccgagttcgc ccggctcgac gacgccgaac tggcctccgg gcggcgcccc ggccagtccc
    12181 tggaacggtt gcgcaggcgg ctgcacgcgc gcgactcctg ggtggtcgac gacgaggcgt
    12241 tcgccgccgc ggtgtcgcgg gtgcgcgcgg aactggtcga cgacctgctg tccatgccct
    12301 tcgacggctc ggtcgccgcc gagcaggcgt tcggccggtt ctcctccggg tggaccgcgc
    12361 ggctggtcgc gggcgtgcac gtcgtcgccg acccgcccac ccgctccggg cacgtgctgc
    12421 tcggcccccg gcagtggcac gaggtgcagg tgctcaagtt cgtgcaccgc cggttcgtgc
    12481 tgctgcgccc ggacctcgcg ctgcaccagc gcggccaggc ccggctgctg accaccctgg
    12541 tcgaggcgct cgaccagtgg ctcggcgacc gctacgaggc cgaccggctg ccgcgcaggc
    12601 tgcacgacct ggtcgagttg gcccgcgtcg agtacgactg gttggccgcc gagcacccgc
    12661 gcgcgctggt cggcgcgacc ggggagggcc ccgaggggca ggccggggtg ctcgccctcg
    12721 ccaggggccg ggccgtgatc gacttcgccg cctcgctcgc cgacgggcag gccgcgacgc
    12781 tgctggaggc gttgtccggc cggaccggac agttctggtc ggacgctttc gtgctgtgag
    12841 ccaccggcag ttccgcagcg gtgggaaaaa taccgagcgt gacacttgga cggtgagtat
    12901 cactcgaacg gtagatgtca cctcgttggt gtgaaccata cgttcacctg gtcgggagcc
    12961 ttcccgacgt cggtgggcgt gggtcggggc acgcactagc gggggaggac ccgtgcgttc
    13021 gtccgatcgc tcgttcttat ccaaacgcgc ctcaaccggt ctgaccgcgg gggtttccgc
    13081 cttcgccctc gtgctcggga tgaccacccc ggcctcggcc caggcgctgc ccgccggacc
    13141 gctcgccgcc caggagaact ccgcccgcca gatcgcggcg ctgcagaggc tgaagcagac
    13201 ccagaccaag gccgagtcca aactggacag caagctcgcg gtcgagtccc gggtgcgccg
    13261 cgaccgctcc gccgccgcgg ccaccccgta cctgcagagc ggggtcaagg tctccgcgac
    13321 cggcaccgtg ctcgtcgaca tcagcgtcga ggaggtcacc gacgacctgc tcggcgcgct
    13381 caccaagtcc ggcgccggga tccgcgccgt gtccgcgggc ctgggggaga tccgggccga
    13441 ggtcccgttc gccgcgctca ccggcatctc cgggcgcgcc gacgtccgca aggtcgagac
    13501 cgcgagcggc gcgatcaccg cctccgccaa gcgggacaag gcacccgcca cgaaggagac
    13561 caaggagcag aaggaagcca gggtcgccgc gagcgtccag tccgccctgg agcagcgcgg
    13621 caccgcggcg ctggtcacca gcgagggcga ccgcgcgcac aacgccgaca ccgcgcgcgc
    13681 cgagtacggg gtcaccggtg tcggcgtgaa gatctgcgcg ctctccgacg gcgtcgactc
    13741 gctcgccgcc tcgcaggccg ccggtgagct gcccgccgtc gacgtgctgc ccacccagga
    13801 gggcgagggc gacgagggca ccgcgatgct cgagatcctg cacgacctgg cgcccggcgc
    13861 cgcgctcggg ttcgcctcgg cgttcaacag cgaggccagt ttcgccgaca acatccgcgc
    13921 cctgcgccaa caactgcgct gcgacatcat cgtcgacgac gtgctctact tcgtcgagtc
    13981 gccgttccag gacgggctga tcgcgcgcgc ggtcaacgac gtcaccgccg acggcgcgct
    14041 ctacttctcc tccgcgggca acgagggcaa caccgtcgac ggcaccgccg gccactggga
    14101 gggcgacttc cgcgactccg gacgcatcgt cggcaagttc gcaggcaccg cgcacgactg
    14161 ggacccgtcg gcgaccaccc aggtgttcca gccgatctcc accgcgtcct cggcgcaggt
    14221 gccggtgacg ctgcactggg cggacccgct gggcgcgtcg gccaacgact acgacctgta
    14281 cctgttcgac cgcaacggaa acgtggtcac cttcagccag gacgtgcagg acggcgagca
    14341 ggacccgtac gagatcctgc agacgccgac cttcggcggc accggcctgc gcctggcggt
    14401 cgtgaagttc tacggcgaga accggtactt ctcgctttcc gctctgcgcg gtcggttctc
    14461 cgactcggcg gacggcctga aggcgttcaa cacccccggt gtcaccgtgg ggcactcggc
    14521 ggccaagcag gcgttcagcg tcgccgccgc gcccgccgcc ggtccgctgc cgttcgacct
    14581 ggaaccgggt gacccggcca acccgcgcgg cccgcacccc ggctcgttca gcgcgacgtc
    14641 cccgctggag cgcttctcct ccgacggccc gcgccgcgtg ttctacaagg ccgacggaac
    14701 cccgatcacg ccgggcaact tcggcgcgac cggtggcgag gtccgcgcca agcccgacat
    14761 caccgccgcc gacggcgtgc tcaccagcgt cgacggcttc gacccgttct tcggcacctc
    14821 ggccgcagcg ccgcacgccg ccgcgatcgc cgggctcgtg ctctccggca accccggcat
    14881 cgcgcaggcg gaggtgcggg aggcgctggt caacaccgcc atcgacctcg gccccgccgg
    14941 gttcgacggc cgcaccggcg ccgggatcat cctcgccgac cgcgtgctcg cctacaccgg
    15001 cgccagcccg caaccccgtg ccctggcaca gaacccgacc atcgccccga ccgacggcgg
    15061 cgacctggtc gacccgggcg acaccgtctc ggtgaccctg ccggtgcgca acaccggcga
    15121 cgccgacgct gtgtctacga gcgttgtcct gacctcgccg acggccggtg tcaccatcgc
    15181 gccgcgctcg cagaactacg gcaccgtcca gaagggacag acggtcagca aggtatacac
    15241 cgtgaccgtc ccgctgagcc accccgtcgg cacgccggtc gtgctcgacg ccagggtgac
    15301 cttcgctgcg gcggcgtccc cgaccaaggc gacgttcacg ttctcggtcg gacggccctc
    15361 gccgaccgtt caggacttcg cctacggcgg cgcacccgtg gccgtaccgg acaacaaccc
    15421 gctcggcgcc agcgtcacca tcccggtctc gggcgtcggc cgcgcgtccc gggtgagctt
    15481 ctcggtcgac ggcgccacgt gcagcaccgc gaccggcgcc accaccgtcg gcctcgacca
    15541 caccttcgtc ggcgacctcg tcggcaccct cacggccccc aacggcgccg tcgccaccat
    15601 ccacagccgc agcggaggcg gcggcaacaa cttctgcaag gtcgtcttcg ccgactcggc
    15661 caccgccgcc ttctcgtcgg tgacctccgc caacgccccg ttcaccggaa gctggcgccc
    15721 caccaccccc ctgaccggct tcgccgcggt catcgccgac ggcacctgga cctacaaggt
    15781 cgtcgacgcc gcgggcggcg acaccggctc gatccgcgcg gtatccctcc acatcaacgg
    15841 ctacctgacc ccacccccgg caggctgacc ccttagccgg cgacggccgc ccgacaccct
    15901 cccggtgccg ggcggcctcg ccgtgtcctc ccgcgagcct ggttcggacg taccgtcttg
    15961 ggtatggggc ggacgcggga tgtggcgggt ggtgggcggg cggttgaggt gccggtggag
    16021 cgggtgccgg ggtggttcac ccgcttcggt gaccgtcatc gcggggtcac ccacacgtcc
    16081 ctcagcgcgg gctcggtcgt gtgtaccgcc acggatgggg ctacggcctc ggtagtggtg
    16141 ccgttcccgc cgttggcggt ggtgggggag cgggatgggc tggaggtcgg tccgctgctc
    16201 gaccacctcg ccgtcagtcg gcgggttggt cttgtgctgg ttcggcttgg cgggcacagc
    16261 ctcggcatcg ctgagccggg gcgggtgttg gtctcgcgca ccgaccgcca cctggtgcac
    16321 gggcgtagtg ccgccggtgg gtggtcgcag cagcggttcg cccggcggcg ggaggggcag
    16381 gccaggcacg cgctggaggc ggccgcgcgg gacatcgcgg aggtgttggt gccgcgcgtg
    16441 ggcgagctcg acgccgtggt gctgggtggg gatcggcagt cgctggacgt gctgcgggcc
    16501 gaccgggggc tggcgccggt cttcgatctc gccatcgatc gcgtgctcga cgtccccgaa
    16561 ccgcggcgca ccgtgctgga ggacgcggtg gagcgcgcct tcgccctgga gatcgtcgtc
    16621 cgcgaccggc cctgaaccgt tcacagcgga cacacagctt cgaggcgcac agtatgccca
    16681 tgagcacgac cccgcccgac ccagcgcccg cggtagaacc cacccccgaa cccgcgcgga
    16741 ccgaggcacc cccggtcgcc cagtcaccgg ccgcctccgt ggtggaggcc ccgcccagga
    16801 cggtcagcct gctggtcgcg ggcttggcgg gcgtggtact cctgctcgtc ggcggcatcg
    16861 cgggctacgc catcggcaac tccggcggcc acgaccgccc cgctccaggc gtctcccgcc
    16921 acggcggccc cggcccccac gcccgccccg acttccccca cccaccccgc cccggcggcc
    16981 agggcaggcg ccccaacacc ccacccgccc ccaccccatc cagtgccacc ccgacctccg
    17041 ccccggccgc cacccccagc agctaacgaa cccagccaag accagcgcga cttcgcgtcc
    17101 agcgccgccc agacctcggc cgccgagcag gtagccgccg ggtgggttgg gtcagagggt
    17161 gccggtggcc aggaggccgc cgtccacgcg cacggtttcg ccggtgatcc aggaggcttg
    17221 gtcggagcac aggaaggcga cgaggtccgc gacgtcctcc ggggtgccca ggcgcttcat
    17281 cgggtagggc gcggacgcct cttcctcccg gtcggcgtac agggccgtgg cgaagcgggt
    17341 cttcaccacg gcgggggcca cggcgttgac ccggatgccc ggtcccagct gccacgccag
    17401 ttcctccgtg agccgcacga gcgccgcctt gctcgccccg tacgccgcga tcacccccga
    17461 ggaccgcagg cccgccaccg aggcgatgtt gatcacaacg ccgccgtgcg cggccatcca
    17521 cgagtggtac gccagctgca cgaagcccag tgccgcgacc acgttcgtgt cgaagatctt
    17581 gcgcacgccg tccaggtcga cgtccaccag cggcccgtac accgggttga tgccggtgtt
    17641 gttcaccagc acgtcgagcc cgcccagctc gtcgacggtc cgcgccacca cccgttcgcg
    17701 gtccgcgtcg acgccggtgt tccccgccac agccagtacc cgcgcgcccg gcgcggcggc
    17761 cgtgatcgac gcggcggctg cgtccaagtc gtcctgcttg cgggagctga tggcgaccgc
    17821 cgcaccccgt ctggccagct ccgtcgcgat ggccagcccg atgccccggc tcgccccggt
    17881 gaccagcgcg gccctgcccg cgtactcggc ggttcccata ccgggactct agccggcggg
    17941 aaacccctcg cgcggcgcgg ctagactggg tccgtggttc tcaacgatgg gtttggggca
    18001 ggcagggctg tgctcaccga ctgatgggcg ggcgggctcg cgggtcacgg cacgcgagcg
    18061 gatcacccct gcccaccacc acccgcaccc acggagctcc ccttgatcac cgcgactgac
    18121 ctcgaactgc gcgcgggctc gcgcatcctg ctcgccgacg cctccctccg ggtgcaggcg
    18181 ggcgaccgca tcggcctcgt cggccgcaac ggcgcgggca agaccacgac cctgcgcgtg
    18241 ctcgcgggcg agggcgagcc ctacggcggc gacctgcgcc gcaccggcga gctcggctac
    18301 ttgccgcagg acccgcgtga gggcgacctg tcggtcaccg cgaaggaccg ggtcttgtcc
    18361 gcgcgcggcc tcgacgaact gctccgcgag atggagaagg cgcagacggc catggccgag
    18421 cacgccgacg actccgtccg cgacaacgcc gtgcgcaagt acgggcggct cgaggagcgc
    18481 ttctccgcgc tcggcgggta cgccgcggag agcgaggccg cgcggatctg ctccaacctg
    18541 ggcctcgccg accggatcct cgcccagccg ctgcgcaccc tctccggtgg tcagcgccgc
    18601 cgggtcgagc tggccaggat cctgttcgcc gcctccgagg cgggcgcggg cggcggcgcg
    18661 ggcaccatcc tgctgctcga cgagccgacc aaccacctcg acgccgactc gatcacctgg
    18721 ctgcgcgggt tcctcaaggg ccacagcggc ggtctggtgg tcatcagcca cgacgtggaa
    18781 ctgctcggcg acgtggtcaa caaggtgtgg ttcctcgacg ccatgcgcgg cgaggtcgac
    18841 acctacaaca tgggctggaa gcgctacctc gacgcgcgcg ccgccgacga gaagcgccgc
    18901 aggcgcgagc gggccaacgc cgagaagaag gcaggcgtgc tcatggagca ggccaacaag
    18961 atgcgcgcga aggccaccaa ggcggtcgcc gcgcagaaca tgatcaagcg cgccgagaag
    19021 ctggtctccg gcctcgacga cgtccgccag tcggacaagg tcgccaagat ccgcttcccg
    19081 gagcccgcgc cctgcggcaa gaccccgctg ctcgccgagg ggctgagcaa gtcctacggc
    19141 tcgctggaga tcttcaccgg cgtcgacctg gccatcgaca agggctcccg ggtcgtcatc
    19201 ctcggcctca acggcgcggg caagaccacc ctgctgcggc tgctgggcgc catggagacc
    19261 ccggactccg gcgaggtcat cgccggtcac ggcctgcgcc tgggctacta cgcccaggag
    19321 cacgagacgc tggaccactc cgccagcgtg tgggccaaca tccggcacgc cgcccccgac
    19381 accggcgagc agcagctgcg ctcgctgctg ggcaccttcc tgttcaccgg cgagcagctc
    19441 gaccagcccg cgggcaccct ctcgggcggc gagaagaccc ggctcgcgct ggccgggctg
    19501 gtctccagcg ccgccaacgt gctgctgctc gacgagccga ccaacaacct ggacccggcc
    19561 agccgcgagc aggtgctcga cgcgctgcgc cgctactccg gggcggtcgt gctggtcacc
    19621 cacgaccccg gcgcggtcga ggcactggaa cccgagcggg tgatcctgct cccagacggc
    19681 agcgaggacc actggtcggc cgagtacctc gaactcgttc agctcgcctg aaattggccg
    19741 ttttgctggg atcttgtatt cgccgatcac gttgagtccc agagctgccg ccgccggtga
    19801 tcagcggcgg cagcaaccat ttgcgcgtct cgtctggcat ttcgcgcggc ggtgttcgat
    19861 cattgcggcg gtaggggcca cccgtggccc cggccacacg tgacggaagg cggacaacgt
    19921 ggctgacctc aagaaaggcg cccggatcac tggcgccctg cgcgacaagc tcgccaccga
    19981 cttgaagaag aagtacgaga agggcgccag catcagggcg ctcgcggaaa gcaccggccg
    20041 ttcctatgga ttcgtgcaca gagtgctctc cgagtcgggc gtgacgctgc gcgggcgagg
    20101 cggggcgacg cggacgaaga agaagtaacc ccgcctgggt gtggcggcgg cggctcaggc
    20161 cgtgcgcggt ccacccggcg ggctgtccac accggagtcc tcggccggtg cgggcacccc
    20221 ggttcccacc cggaccacgt ccacgcggtc ccgggtccgg ccgagcgcga tcgcggcgcc
    20281 cgccagcacc gcggggtaca ccaggtagcc ccagcgggtc gcgggcgcga gcacgatcgc
    20341 cagtccgagg ccgaccgctg agcacgccag cgcgtccccc gccgtcctcg gtggacggac
    20401 gagcacccag gtcgccgtgg cggcggcggc cagtcccaac aggacgagcg cgacggcgtg
    20461 cccgaccggg ccgagcccgg cgaccaggtg ccccggcagc gggctggacg ccggtgagga
    20521 cgcctggccg agaccgaccg ggaacttcag cacgtgctcg acgaacgacg tcgggtcggc
    20581 cagcagcacc gggagcacca cggccgaccc gaccacgacg agcgcggtgc tgaacgcgcc
    20641 gagcgcgcgc cacccccggg tcgcggcgac cccgatggcg agcaccgcga ccgcgggcac
    20701 cgcggtcaac ttcatcgtca ccagcaccgc gccgagcgcg cccgcgcccc acgcactggc
    20761 cgggtcggcg cggtaggcga gcgcggccgc ggccacgatc agcgccacca ccgcgacgtc
    20821 gtcaccggcg gcggcgaggg tgagcgcggt caacgggctg gccaccacca ggtgcgcggc
    20881 gcgcaccggg agcaccggct tgccgatcgc ccaccaggcc agcaccagcg ccgcggcggt
    20941 caccacgagg aacgccaccc tggcgtcggt cagcgggtgg tcgccgaaca gcgcgcgcgg
    21001 gaacccgaac accgtcatcg acgggccgta cggggtgtag tcgtccgggt gcggcgcccg
    21061 gccgagcgtg gccaggtcgg tgtacggggt gccgttggcg aacaggtccc gcgccgatcg
    21121 ttcgatgacc c
//
