LOCUS       NZ_JAMTCR010000004     12091 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinokineospora globicatena strain DSM 44256
            LV79DRAFT_scaffold00003.3, whole genome shotgun sequence.
ACCESSION   NZ_JAMTCR010000004
VERSION     NZ_JAMTCR010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora globicatena
  ORGANISM  Actinokineospora globicatena
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 1057855)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1057855)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2022) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: AllPaths v. r46652
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 261.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024171945.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:43:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,731
            CDSs (total)                      :: 6,666
            Genes (coding)                    :: 6,609
            CDSs (with protein)               :: 6,609
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 49 of 57
            Pseudo Genes (internal stop)      :: 2 of 57
            Pseudo Genes (multiple problems)  :: 1 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:43:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 826048
            Orig. end                         :: 838139
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAMTCR010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12091
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12091
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12091
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7091](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7091
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(<654..1667)
                     /locus_tag="LV79_RS22640"
                     /old_locus_tag="LV79_004455"
                     /pseudo=""
     CDS             complement(<654..1667)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="LV79_RS22640"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004455"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGQLLVGVSKSGCAAPRRRGPGVPAVVAADATRWRGAPGADRARP
                     AERPRGDGCGSGVGDARRGHRQFSPTDPGRAPAERYPRVAEPAYAGGGSALLRSHQQHQ
                     SGVGMSVSDTSTSTTDTATSSPGLPGQRRSDGESRAGAAHQAVREAWVVLHRVVADLPD
                     PAFREPSLLPGWSRAHVVSHLARNADALVNLLTWARTEVEHPAYTSRADRDADIEDGAG
                     REARVIREDLYAACDRFHTAIARLGESEWTATVTHPSGRALPAAEIPELALFEAWNHLV
                     DLDAGTGYADIPVAHLDRLLDLAVRPHRARADGLPLRLVADLPDGRQRTWELAIATH"
     gene            1718..4570
                     /gene="uvrA"
                     /locus_tag="LV79_RS22645"
                     /old_locus_tag="LV79_004456"
     CDS             1718..4570
                     /EC_number="3.1.25.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="uvrA"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686461.1"
                     /locus_tag="LV79_RS22645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004456"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_253840181.1"
                     /transl_table=11
                     /translation="MADRLVVRGAREHNLRGVDIDLPRDSLVVFTGLSGSGKSSLAFDT
                     IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITE
                     VYDYLRLLYARAGKPHCPTCGEPISKQTPQQIVDQVLAMESGVRFQVLAPVVRGRKGEY
                     LDLFANLQTQGYSRALVDGAVHQLTEPPKLKKQEKHHISVIIDRLAVKASSKQRLTDSV
                     ETALRLADGLVELEFVDLPDNDPHRVRGFSEHLACPNGHPLGVEDLEPRSFSFNSPYGA
                     CPECTGIGVKKEVDPELVVPDDELSLADGAIAPWAGGQTAEYFVRLLTSLAETIGFRMD
                     VPWRRLSAKAQKAVLHGVSDQVHVRYKNRYGRERSYYAAYEGVIPFLERRQEQTDSEYM
                     REKYEGYMREVPCPACRGSRLKPEILAVTLAHGTEGDKSIAEVSNMSIGECSAFLDGLK
                     LGKRETMIAGAVLKEIQARLRFLLDVGLDYLSLDRASGTLSGGEAQRIRLATQIGSGLV
                     GVLYVLDEPSIGLHQRDNHRLIETLTRLRDLGNTLIVVEHDEDTIRASDWVVDIGPGAG
                     EHGGKVVHSGTFKELLKNKESLTGAYLSGRSEIPMPALRRAIDKKRQLTVVGAREHNLR
                     GIDVSFPLGALVSVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRIKGLEHVDK
                     LVQVDQSPIGRTPRSNAATYTGVFDHMRKLFASTTEAKVRGYQPGRFSFNVKGGRCEAC
                     AGDGTIKIEMNFLPDVYVPCEVCKGARYNRETLEVHYKGKTIAEILDMPIEEAAAFFEP
                     IKAIHRHLATLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYILDEPTT
                     GLHFEDIRKLLGVINGLVDKGNSVIVIEHNLDVIKGSDWIVDMGPEGGSGGGMVVAEGT
                     PEDVVKADGSYTGEFLAHVM"
     misc_feature    complement(1719..1733)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            4745..5011
                     /locus_tag="LV79_RS22650"
                     /old_locus_tag="LV79_004457"
     CDS             4745..5011
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LV79_RS22650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LV79_004457"
                     /product="hypothetical protein"
                     /protein_id="WP_253840182.1"
                     /transl_table=11
                     /translation="MFETTELEARVVKPHRVTAASLALIDGGAGVRAWDDRKGITAPAE
                     FRLLERGRHRAPAAGLGQGRGEQCLRMAPVRAGADQRGPVRAG"
     gene            5001..7091
                     /locus_tag="LV79_RS22655"
                     /old_locus_tag="LV79_004458"
     CDS             5001..7091
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="LV79_RS22655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004458"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_253840183.1"
                     /sec_met_domain="YcaO (E-value: 5.5e-60, bitscore: 199.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGDTGNGVDDPTRVTPGRVAAGAAVDEPTQVTSRAVVLGADDPT
                     QATSSAVAASVVAAVDGRAADAGRVGDAGRAGGDPLPGDETTKMVVVPVLEPRAEPRAR
                     AVRSREWDRHLRDCLRREFGSKVTVSGEPLVQGARLAVVRGEDPGFERRARLAKTRALT
                     VTVVDGVIELGPLAVPGEPGCAACARARRVGAAAATADERDPDATEVVRDREIPAEAVA
                     ALDQMVRAAVEGDKALAGYVVEIGAGEPLWHKVIPMPDCDLCGGADGIATVGIPEDEDD
                     PEALLQALAGWVDPLTGVIPWVSVSEPLTGGPFVGTAAPPHLVVGREVRSMPIGWGKGM
                     TRHAAIVSAVGEAIERYSASLPDPGRVVWARAADLEGEVLDPREFPLYEPEQYATRGFP
                     YVPYDRRIDHPWVRGNWLGTDKSVWVPAVFSYLAMGLLPEHLISQGTSNGLAAGADADS
                     AAVCATLELVERDAMMCAWLSGAKGRFVELDDTLDIEVTDVVDALREAGPSVEVYVLPT
                     SAYGTTAVALAIGDGRRWPAISLGLGADRSPRAAIRAAVLELAQTAPHLAALLRDGHRA
                     PRHAGEVREMLDHAAFYFPLGRMEAFDRLRCGGTSRLADLPEPAFDTSVADLAGQLGTA
                     GIRVAVVDVTSADVATSPFRVVRAVSPDLQPISYGHGVHRAPVARLRHRGVPIRRLVHP
                     IW"
     misc_feature    6123..6125
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7139..8380
                     /locus_tag="LV79_RS22660"
                     /old_locus_tag="LV79_004459"
     CDS             7139..8380
                     /GO_function="GO:0016158 - 3-phytase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686458.1"
                     /locus_tag="LV79_RS22660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004459"
                     /product="phytase"
                     /protein_id="WP_253840184.1"
                     /transl_table=11
                     /translation="MRTAAVLGSLVLLPLLASPAAADLPQVRATVETQPNYDDEGADAD
                     DPAIWVNHARSDRSRVVGTLKNGGLAVFDLGGTQVQHFPTPPAPTPEAEAGRFNNVDIV
                     QGARVGRRTLDLAVVSDRGRDRIRVYAIDRAGVLTDVTTATPPRAFSATETEVDEQRTA
                     YGLTVVPDPDGGAPWVVVSRRHETRLGVFRLADDGAGRITYRRVDTVDLPATFAVPGGN
                     WSPCAEPGEGPQVEGMVFDPTDGTLYAAQEDVGIWRISLRHGRFGKPALVDKVREFGRP
                     AVYDDATEECSFTGPPSPAAGRYLTADAEGLTIAYGKRGEKQLLASSQGDSTFVTYDIT
                     RGNPKHTGGFTVASSSTVDGVQHSDGAAVVTTPLGRDYPHGLLVLHDGENTPGDRESTN
                     FKFVRWDRVPGSIR"
     gene            complement(8426..9628)
                     /locus_tag="LV79_RS22665"
                     /old_locus_tag="LV79_004460"
     CDS             complement(8426..9628)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LV79_RS22665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LV79_004460"
                     /product="hypothetical protein"
                     /protein_id="WP_253840185.1"
                     /transl_table=11
                     /translation="MTSRWAFVAALATTGALLLRHPAPPGAVGGWGWLVLVAATAALVA
                     LWRFPGRAWPWVLVVGGALSTADAVLWVDNWPLPPETSAAVRLQVVSVITSVAAVLLLL
                     GALGGAGRLLAVEHRAHGAALAGIAVGAFTASGPLARSRFEPSIWDLVPFVAAGLAVAG
                     GAAAVLVSRRDSRTTAGPPWVLAAGVLAVAASALPELDDRLRLVSVIALVGLAALTAVR
                     ATLETTALVVVAVVGIALVRAGIRLDGHPVGARPSVLAWLALVGGVLVFAAFALTAVRA
                     LLFTVTATAAGLVLPVFVDDGSGYAMALLGVGAGLVVLAGSVVAERCGDSPLVVVVLGL
                     AGASAGPLGDLGLGNGVLLDNNHPTWWVTLALVAAAALVATGAAMERYGTRSPITAELS
                     A"
     misc_feature    complement(8555..8557)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9744..11162)
                     /locus_tag="LV79_RS22670"
                     /old_locus_tag="LV79_004461"
     CDS             complement(9744..11162)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005457918.1"
                     /locus_tag="LV79_RS22670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004461"
                     /product="cation:dicarboxylate symporter family
                     transporter"
                     /protein_id="WP_253840186.1"
                     /transl_table=11
                     /translation="MPGSPPPPETDSANPPRRRDRTHLLYVAVIVAVVLGVAVGLLFPG
                     AAKGLAPLGTAFVGLVKMMISPIIFCTIVLGVGSVARASRVGRVGGLALGYFLVMSTVA
                     LAIGLLVGNLLHPGDGLRLTEALRASGEAQAAKGGESTTEFLLGLIPTSLLSSLTEGQV
                     LQTLLVALLVGFALQLMGPSGEPVLRGVGHVQRLVFRILAMIMWAAPIGAFGAIAAVVG
                     ATGAGALKSLAVIMLGFYATCVLFVVVVLGLLLWAVTRLNVFSLLRYLGREFLLILSTS
                     SSEVALPRLIAKMEHLGVSKPVVGIAVPTGYSFNLDGTAIYLTMATLFVANATGSPLSL
                     GEQFSLLVFMVVAAKGAAGVSGAGLATLAGGLQSHRPDLVDGVGLIVGIDRFMSEARAL
                     TNFAGNAVATVVIGAWTRELDHDRAVAVLSGRQPFDEETQLDAGGGDATRGSPPPAAPD
                     SSARANARESAREA"
     gene            complement(11244..11618)
                     /locus_tag="LV79_RS22675"
                     /old_locus_tag="LV79_004462"
     CDS             complement(11244..11618)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686081.1"
                     /locus_tag="LV79_RS22675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_004462"
                     /product="DUF1844 domain-containing protein"
                     /protein_id="WP_253840187.1"
                     /transl_table=11
                     /translation="MNDASATPGPATSDDTLDNLRELADIPSVEVISRAAVMLMSAAAE
                     RLGLADEDPTTSPRRDLDEARRLITALAGLVTASVEYLGPHAAPIRDGLQSLQKAFREY
                     SAFPDEPGQGPGEKFTGPVY"
ORIGIN
        1 gtgatccgct tcgtttggcg ccacgacgac gccgcgcagt gggtcaagtc gctgttcgac
       61 gggctggcgc tgcaccgggt cgcgctcttc ggcgtcggcg tggcgatctg gctgtggacc
      121 aggcaccgga tgtccggccc gcacctggcc ctctacgggg tcgccgtgct ggtcgcccag
      181 gacgcgcact cctacttcgc cgacaccccg tccaccatcg ccttcggtgt ggtgctcgtc
      241 ggcatcgtcg ccgcggccgg gggaccggac tgggcggtgc tgcgcgggct gactcggccg
      301 atccgctggc tggccgggat ctcctttggc gtctacctgg tgcaccagga actcggcttc
      361 gtgctggcca ggtacctgct cgacaagggc atcggcccct ggggtcggct gctggcctgc
      421 gtggcgatgg cgctgctgct cggctgggcg atcaccaggc tcgtggagcg cccggcgcac
      481 gcctggctga ccgcgcacgg cccgaccgcg tgggcctggc tgcggtcgaa ggtcgagcgt
      541 cagccccagg cgcccaactc cggcggcgtc ccggtcagcc cggccccgtc gcccctgcct
      601 gccagccacc cgagtaccac cggcgccggt ccggtcagct cccgcgagct ggagtgggtc
      661 gcgatggcca gctcccaggt gcgctgacgc ccgtcgggca ggtccgcgac cagccgcagc
      721 ggcagcccgt cggcgcgcgc ccggtgcggc cggaccgcga ggtcgagcag ccggtccagg
      781 tgcgccaccg ggatgtcggc gtagccggtg cccgcgtcca ggtcgaccag gtggttccac
      841 gcctcgaaca gcgcgagctc cgggatctcg gcggcgggca gcgcgcggcc ggacgggtgc
      901 gtgaccgtcg ccgtccactc gctctcaccc agccgagcga tagcagtgtg gaatcggtca
      961 cacgcggcgt agaggtcctc gcggatcacc cgcgcctcgc ggcccgcgcc gtcctcgatg
     1021 tcggcgtcgc ggtcggcccg actggtgtac gccgggtgct cgacctcggt ccgcgcccag
     1081 gtcagcaggt tgaccagcgc gtcggcgttg cgcgcgaggt ggctgaccac gtgcgcccgc
     1141 gaccagccgg ggagcaggct cggctcgcgg aacgccgggt ccggcaggtc ggcgaccacc
     1201 cggtgcagca cgacccacgc ctcgcgcacc gcctggtgcg cggccccggc cctgctctcc
     1261 ccgtcggagc ggcgctgacc agggagtccg ggggatgatg ttgccgtatc ggtcgtgctc
     1321 gtggacgtgt cggacacgct catacccacc cccgactggt gctgctggtg tgatcggagc
     1381 aacgcgctcc caccaccagc gtaggccggt tcggctactc gcgggtaccg ctccgcgggt
     1441 gcacggccgg ggtcggtcgg cgagaattgt cggtgccccc gtctagcatc cccaacgcca
     1501 ctcccgcagc catcgccacg aggtcgttcc gcaggtcgag cacggtccgc gcccggtgcc
     1561 ccacgccacc gggtggcgtc ggccgcgacc accgcgggta ccccgggccc gcggcggcgg
     1621 ggggcggcgc acccagattt ggacacaccc accagcagtt gacccatgag cagtgcggtc
     1681 cgagcgatcg ccgctcagca ctaccgaagg gacctcagtg gccgaccgcc tcgtcgttcg
     1741 cggcgcccgg gagcacaacc tgcgcggcgt ggacatcgac ctgccccgcg acagcctcgt
     1801 ggtgttcacc gggctctccg gctcgggcaa gtccagcctc gcgttcgaca cgatcttcgc
     1861 cgagggccag cgccgctacg tcgagtcgct ctcggcctac gccaggcagt tcctcggcca
     1921 gatggacaag ccggacgtcg acttcatcga gggcctctcg cccgcggtgt ccatcgacca
     1981 gaagtccacc agccgcaacc cgcgttccac ggtcggcacc atcaccgagg tctacgacta
     2041 cctgcgcctg ctctacgcgc gcgcgggcaa gccgcactgc ccgacctgcg gtgagccgat
     2101 cagcaagcag accccgcagc agatcgtcga ccaggtgctg gcgatggagt ccggggtccg
     2161 cttccaggtg ctggcgccgg tcgtgcgcgg ccgcaagggc gagtacctgg acctgttcgc
     2221 gaacctgcag acccagggct actcgcgcgc gctggtcgac ggcgcggtgc accagctgac
     2281 cgagccgccg aagctcaaga agcaggagaa gcaccacatc tcggtgatca tcgaccggtt
     2341 ggcggtgaag gcgagttcca agcagcggct gaccgactcg gtggagaccg cgctgcggct
     2401 ggccgacggc ctggtcgagc tggagttcgt cgacctgccc gacaacgacc cgcaccgcgt
     2461 ccgcggcttc tccgagcacc tggcctgccc caacggccac ccgctcggcg tcgaggacct
     2521 cgaaccccgg tcgttctcct tcaactcgcc ctacggcgcg tgcccggagt gcaccggcat
     2581 cggcgtgaag aaggaggtcg acccggagct ggtcgtcccc gacgacgagc tgtcgctggc
     2641 cgacggcgcc atcgcgccgt gggcgggcgg gcagaccgcg gagtacttcg tgcggctgct
     2701 cacctcgctc gccgagacca tcgggttccg gatggacgtc ccgtggcggc ggctgagcgc
     2761 gaaggcgcag aaggccgtgc tgcacggggt gagcgaccag gtgcacgtcc gctacaagaa
     2821 ccgctacggc cgcgagcgct cgtactacgc cgcctacgag ggcgtgatcc cgttccttga
     2881 gcggcgccag gagcagaccg actccgagta catgcgcgag aagtacgagg ggtacatgcg
     2941 ggaggtgccg tgccccgcgt gccgggggtc gcggctcaag cccgagatcc tggcggtcac
     3001 gctggcgcac ggcaccgagg gcgacaagtc catcgccgag gtgtccaaca tgtccatcgg
     3061 cgagtgctcg gcgttcctcg acggcctgaa gctgggcaag cgcgagacga tgatcgcggg
     3121 cgccgtgctc aaggagatcc aggcgcggct gcggttcctg ctcgacgtcg gcctcgacta
     3181 cctctccctg gaccgggcct ccggcacgct ctccggcggc gaggcgcagc gcatccggtt
     3241 ggcgacgcag atcgggtccg gcctggtcgg ggtgctctac gtgctcgacg agccgtcgat
     3301 cggcctgcac cagcgcgaca accaccggct catcgagacg ctgacccggc tgcgcgacct
     3361 gggcaacacg ctgatcgtgg tcgagcacga cgaggacacc atccgcgcct cggactgggt
     3421 ggtcgacatc ggacccggcg cgggcgagca cggcggcaag gtcgtgcaca gcggcacctt
     3481 caaggagctg ctcaagaaca aggagtcgct gaccggcgcg tacctgtcgg gccgcagcga
     3541 gatcccgatg cccgcgctcc gccgcgcgat cgacaagaag cggcagctga cggtggtcgg
     3601 tgcccgtgag cacaacctgc gcggtatcga cgtgtccttc ccgctgggcg cgctcgtgtc
     3661 ggtcaccggt gtctccgggt cgggcaagag cacgctggtg aacgacatcc tggccacggt
     3721 gctggcgaac aagctcaacg gcgcccgcca ggtgcccggc aggcacaccc ggatcaaggg
     3781 cctggagcac gtcgacaagc tggtgcaggt cgaccagtcg ccgatcggcc gcacgccgcg
     3841 ctccaacgcc gccacctaca ccggcgtgtt cgaccacatg cgcaagctgt tcgcgtccac
     3901 gaccgaggcg aaggtgcgcg gctaccagcc gggccggttc tccttcaacg tcaagggcgg
     3961 ccgctgcgag gcgtgcgcgg gcgacggcac catcaagatc gagatgaact tcctgccgga
     4021 cgtgtacgtg ccgtgcgagg tgtgcaaggg cgcccggtac aaccgggaga ccctggaggt
     4081 gcactacaag ggcaagacga tcgccgagat cctggacatg ccgatcgagg aggccgccgc
     4141 cttcttcgag ccgatcaagg cgatccaccg gcacctggcc accctggtcg acgtcggcct
     4201 cggctacgtc cggctgggcc agcccgcacc gacgttgtcc ggcggcgagg cgcagcgggt
     4261 gaagctggcc agcgagctgc agaagcgctc gaccggccgc accgtctaca tcctcgacga
     4321 gccgaccacc ggcctgcact tcgaggacat ccgcaagctg ctcggcgtga tcaacggcct
     4381 ggtcgacaag ggcaactcgg tgatcgtcat cgagcacaac ctggacgtca tcaagggctc
     4441 ggactggatc gtcgacatgg gacccgaggg cggctccggc ggcggcatgg tggtggcgga
     4501 gggcacaccg gaggacgtcg tcaaggccga cggcagctac accggggagt tcctcgcgca
     4561 cgtgatgtga ccggatgggg cgccgccggt ggcctgggtc accggcggcg actaccgccg
     4621 gagttcgctc ggagacgtgc ggtaaccagc ggaaacgaca tctggacatg gtgtatcccg
     4681 gtcgcggatg ctgactccta cctcgtagcc gcgacagttc gcgggtcgcg cgaggaggac
     4741 gtcagtgttc gagacaacgg aactcgaggc cagagtcgtg aagccgcacc gggtcaccgc
     4801 agcctcgctc gccctcatcg acggcggcgc gggcgtgcgc gcgtgggatg accgcaaggg
     4861 catcaccgcg cccgccgagt tccgcctgct cgagcgcggc cgccaccgcg cgcccgcggc
     4921 gggtctcggg cagggccgcg gcgagcagtg cctgcggatg gccccggtgc gggcgggggc
     4981 cgaccagcgg gggccagtgc gtgccgggtg acacgggcaa cggcgtcgac gaccccacgc
     5041 gtgtgacccc ggggcgggtc gcggcggggg ccgccgtcga cgaaccgacc caggtgacct
     5101 cgcgggccgt cgtgctgggc gcggacgacc cgacgcaggc cacctcgagc gcggtcgcgg
     5161 cgagtgtcgt cgccgcggtc gacgggcgcg ccgcggacgc tgggcgggtc ggggacgctg
     5221 gacgggccgg gggagacccg ttgccggggg atgagacgac caagatggtg gtcgtcccgg
     5281 tgctcgaacc cagggctgag ccgcgcgccc gcgcggtgcg gtcccgggag tgggaccggc
     5341 acctgcggga ctgcctgcgc cgggagttcg ggtcgaaggt cacggtgtcc ggtgagccat
     5401 tggttcaggg cgcgcggctc gcggtcgtgc ggggcgagga cccggggttc gaacgtagag
     5461 cgcggttggc gaagactcgc gcgttgaccg tgactgttgt ggacggtgtt atcgagctag
     5521 ggccgttggc ggtgccgggg gagccggggt gcgccgcgtg cgccagggct cgtcgggttg
     5581 gggctgccgc cgcgacggcg gatgagcgcg accccgacgc cacggaagtc gtgcgtgacc
     5641 gggagatccc ggccgaggcg gtcgccgcct tggaccagat ggtgcgggcc gccgtggagg
     5701 gtgacaaggc gctggccggg tacgtcgtgg agatcggcgc gggtgagccc ttgtggcaca
     5761 aggtgatccc catgcccgac tgcgacctgt gcggcggcgc ggacggtatc gccaccgtcg
     5821 gcatccccga agacgaagac gatcccgagg cgctactcca agcgctagcg ggctgggtcg
     5881 accctcttac cggtgtcatc ccgtgggtgt cggtaagcga accgctgaca ggtggcccct
     5941 tcgtgggcac ggcagctccg ccgcatctag tggtcggccg cgaggttcgc tctatgccga
     6001 tcgggtgggg taagggcatg acccgccacg cggcgatcgt ctccgcggta ggggaagcga
     6061 tcgagcggta ctcggcatcg ctaccggacc cgggcagggt ggtgtgggcg cgcgcggccg
     6121 acttagaggg cgaggtgctc gacccacgcg agttccccct ctatgagccc gagcagtacg
     6181 cgacccgcgg cttcccttac gtcccctacg accggcgcat cgaccacccg tgggtgcgcg
     6241 gcaactggct cggcacggac aagagcgtct gggtgcccgc cgtcttcagc tacttggcga
     6301 tgggcctcct gccagagcac ctgatcagcc aaggtacgtc taacggtctc gctgcgggcg
     6361 cggacgccga tagcgctgcc gtgtgcgcga ccctggaact ggtcgagcgc gacgccatga
     6421 tgtgcgcgtg gctctccggc gccaagggcc ggttcgtcga actggacgac acgctcgaca
     6481 tcgaggtcac cgacgtcgtc gacgcgctgc gcgaagcggg cccctcggtc gaggtgtacg
     6541 tgctgccgac ctccgcctac ggcaccaccg ccgtcgcgct cgcgatcggc gacggcaggc
     6601 gctggcccgc gatctccctc ggcctcggcg ccgaccgctc gccccgcgcc gccatccgcg
     6661 ccgccgtcct cgaactggcc cagaccgcgc cgcacctggc cgccctgctg cgcgacggcc
     6721 accgcgcgcc ccggcacgcc ggtgaggtca gggagatgct cgaccacgcc gcgttctact
     6781 tcccgctcgg ccgcatggag gccttcgacc ggctgcgctg cggcggcacc tcccggctgg
     6841 ccgacctgcc cgaacccgcc ttcgacacct cggtcgccga cctggcgggc cagctgggca
     6901 cggcgggcat ccgggtcgcg gtggtcgacg tgaccagcgc ggacgtggct accagcccgt
     6961 tccgggtggt ccgcgcggtc agccccgacc tgcagccgat cagctacggc cacggcgtgc
     7021 accgcgcccc ggtcgcccgg ttgcgccacc gcggcgtccc gatccgcagg ctggtgcacc
     7081 cgatctggtg acccggagtt caccgggtgg acagcgccgg tgggcaggat caccgcgtat
     7141 gcgcaccgcg gccgtcctcg gctccctggt cttgctcccc ctcctcgcct cacccgccgc
     7201 cgccgacctc ccgcaggtca gggcgacggt cgagacccag cccaactacg acgacgaggg
     7261 cgccgacgcc gacgacccgg ccatctgggt caaccacgcg cgctcggacc gcagccgcgt
     7321 cgtcggcacc ctcaagaacg gcgggctcgc cgtgttcgac ctgggcggca cccaggtcca
     7381 gcacttcccg accccaccgg cgcccacccc ggaggccgag gcgggccggt tcaacaacgt
     7441 cgacatcgtg cagggcgccc gcgtcggccg ccgcacgctc gacctcgccg tcgtctccga
     7501 ccggggccgc gaccgcatcc gggtctacgc gatcgaccgc gccggtgtgc tcaccgatgt
     7561 caccaccgcc acgccgccgc gcgcgttcag cgccaccgag acggaggtcg acgagcagcg
     7621 caccgcctac ggcctcaccg tggtgccgga cccggacggt ggcgcgccct gggtcgtggt
     7681 gagcaggagg cacgagaccc gcctcggcgt gttccggctc gccgacgacg gtgctggccg
     7741 tatcacctac cgccgtgtcg acacagttga cctacctgcg acgtttgccg tgccgggcgg
     7801 caactggtcg ccgtgtgcgg agccggggga ggggccgcag gtcgaaggca tggtcttcga
     7861 cccgaccgac ggcacgctct atgccgctca ggaagacgtg ggcatctggc gaatctcgct
     7921 gcgccacggc cgattcggca agcccgcttt ggtcgacaag gtgcgcgagt tcggtaggcc
     7981 tgccgtgtac gacgacgcta ccgaggagtg cagcttcact ggcccgcctt cgcccgccgc
     8041 aggccgctac ctcaccgccg acgccgaggg tctcaccatc gcctacggca agaggggcga
     8101 aaaacagcta ctggcctcta gccaggggga cagcaccttc gtcacctacg acatcacgcg
     8161 cggcaaccct aagcacaccg gtggcttcac cgtcgcctct agctccacag tggacggcgt
     8221 ccagcacagc gacggcgccg cagtggtcac caccccgctt ggccgcgact acccccacgg
     8281 cctcttggtc ctccacgacg gtgagaacac cccgggagac cgcgagagca ccaacttcaa
     8341 gttcgtccgc tgggaccgag tgcccggctc gatccgctag acctcgattg cctctagtcg
     8401 tgacctcccg cgcgggaggt cgcgactagg cgctcagttc ggcggtgatc ggcgaacgcg
     8461 tgccgtagcg ctccatcgcc gcgccggtag cgacaagtgc ggcggcagca actagggcca
     8521 gggtcaccca ccacgtgggg tggttgttgt cgagtaagac cccgttgccc aggcccagat
     8581 ctcccaacgg tcctgctgag gccccggcca acccgagcac gaccaccacc agcggtgagt
     8641 cgccgcatcg ctcagcgaca acgctgcctg cgaggaccac tagtcctgcg ccaactccga
     8701 gtagtgccat cgcatacccg ctgccatcgt cgacgaacac cggtagcacc aaccccgccg
     8761 cggtagccgt gacggtgaat agcagcgcgc gcaccgcagt cagcgcaaac gcggcgaaca
     8821 ccaacacgcc gcccaccaat gccaaccacg ccaacacgct cggccgcgct cccaccgggt
     8881 ggccatcgag ccgaatcccc gcccgcacca acgcgatccc caccaccgcg acgaccacca
     8941 gcgccgtagt ctcaagggtc gcccgcaccg ctgttagcgc tgccagtccg accagcgcga
     9001 tcaccgatac cagtcgcaga cggtcatcca gctcaggtag tgcgctagcg gccacagcga
     9061 gcacgccagc cgcgagcacc cacggcgggc ctgccgtcgt ccgggaatcc cgcctgctca
     9121 ccagcacggc ggcagcgcca cccgccaccg cgagaccggc ggccacgaac ggcaccaggt
     9181 cccagatcga gggctcgaac cgggacctgg ccagcggccc gctcgcggtg aacgcgccga
     9241 ccgcgatccc ggccagcgcc gcgccatgcg cccggtgctc caccgcgagc agccgcccgg
     9301 cacccccgag ggcaccgagg agcagcagca ccgcggcgac cgaggtgatc accgacacca
     9361 cctggagccg gaccgccgcg ctggtctccg gcggcagcgg ccagttgtcc acccacaaca
     9421 ccgcgtccgc cgtgctcaac gcgccaccga cgacgagcac ccacggccac gcgcggccgg
     9481 ggaaccgcca cagcgcgacc agcgcggcgg tcgcggcgac caggaccaac cagccccagc
     9541 cgcccacggc ccccggcggc gcggggtggc gcagcagcag cgcgccggtg gtggcgaggg
     9601 cggcgacgaa ggcccaccga gaggtcatga tcgccaccgt acagcgcacg acggaggtcg
     9661 ggggccgcta cgccgaaccg cccgcaccgg gggcatcggt cgcgggcggc tcacgcggta
     9721 caacgaacga cagcgcggcc aggctacgcc tcacgagcgc tttcccgtgc gttcgcccgt
     9781 gcggacgagt ccggcgccgc aggcggcggt gacccccgcg tagcgtcacc gccgcctgcg
     9841 tccagttggg tctcctcgtc aaacggttgg cggccggaga gcaccgcgac ggcccgatcg
     9901 tgatcaagct cccgggtcca cgcgccgatc accacggtcg ccaccgcgtt gcccgcgaag
     9961 ttggtcagcg cccgggcttc cgacatgaac cggtcgatgc ccacgatcaa cccgacgccg
    10021 tccaccaggt ccggccggtg cgactgcagc ccgcccgcca gcgtcgccag cccggccccg
    10081 ctcaccccgg cggcgccctt cgcggccacg accatgaaca ccagcaagga gaactgctcg
    10141 ccgagcgaca gcggcgaccc ggtcgcgttg gccacgaaca acgtcgccat cgtcaggtag
    10201 atcgcggtcc cgtcgaggtt gaacgagtac cccgtgggca cggcgatgcc cacaaccggc
    10261 ttgctgacac caagatgctc catctttgcg atcagccgag gcagcgctac ctccgacgac
    10321 gacgtcgaca ggatcaagag gaactccctg cctaggtagc gcagcaagga gaagacgttg
    10381 agccgcgtca ccgcccacaa gagcaaaccc agcaccacta cgacgaacag cacgcatgtg
    10441 gcgtagaaac ccaacatgat gacggcgagg ctcttgagcg caccggcccc ggtagcgcca
    10501 accaccgcgg ctatcgcccc gaacgcgccg atcggcgcgg cccacatgat catggccagg
    10561 atccggaaca ccaaccgctg cacgtgcccc accccgcgca gcaccggctc gccggagggc
    10621 cccatcagct gcagcgcgaa cccgaccagc agcgccacca gcagggtttg cagcacctgc
    10681 ccctcggtga gcgacgacag cagcgacgtc gggatgagcc ccagcaggaa ctccgtcgtc
    10741 gactcgccgc ccttggccgc ctgcgcctcg ccgctggccc gcagcgcctc ggtcagccgc
    10801 agcccgtccc cggggtgcag caggttgccc accagcagcc cgatggccag cgccaccgtc
    10861 gacatcacca ggaagtagcc cagcgccagc ccgccgaccc ggccgacgcg gctcgccctg
    10921 gccacggacc cgacgccgag cacgatcgtg cagaagatga tcggactgat catcatcttc
    10981 accagcccca cgaacgccgt tccgagcggc gccaagccct tcgcggcgcc cgggaacagc
    11041 agaccgactg cgacgccgag cacgaccgcc acgatcaccg ctacatagag caggtgcgtg
    11101 cggtcgcgtc ggcgcggcgg gttagcgctg tctgtctcgg gtggtggtgg ggaaccgggc
    11161 atcgctgcct cccaggggat cgggtcgttc caccttcctc cccggtgtgg ccgcggtcac
    11221 gcttgtggtc gtaaagttcg cgatcagtag accggtccgg tgaacttctc accggggccc
    11281 tggcccggct cgtccgggaa cgcggagtac tcgcggaagg ccttctgcag cgactgcagg
    11341 ccgtcgcgga tcggcgcggc gtgcgggccg aggtactcga ccgaggcggt caccagcccg
    11401 gcgagcgcgg tgatcagcct gcgggcctcg tccaggtcgc ggcgcgggct ggtggtcggg
    11461 tcctcgtcgg cgaggccgag gcgctcggcg gcggcggaca tcagcatgac ggcggctcgg
    11521 ctgatcacct cgacgctggg aatgtcagcc agctcgcgca ggttgtccag ggtgtcgtcc
    11581 gaggtggcgg ggccgggtgt ggcggaagcg tcgttcacgg tctgctaccc ttgcacgtgc
    11641 gaccagcccc cgtcagcgcg ggggcggcaa agtggagccc ccgctcccac ccaggccacc
    11701 gcgaggtgtc cgggtccggt tgccgcggac catcgggttc tcacctggtg gtcctgtggt
    11761 gtgtcctgac gcctgtcgtc gggcaatcgg ttggaagcgg gccccggcgt gccacctggc
    11821 accacggggt ccgagctgtt tttggggacc tcacgtgccg tgcacgtcgc gagacggacg
    11881 tgccgcgtcc gcccacccgg gcgggcgggg aacgcaaccg gcagggtgcc ccgaggtgat
    11941 cgggtggccc cgccggacag cattaccgga ccaaggaggc cccatcagca cggagacacg
    12001 catcaacgac cgcatccgcg tgccggaggt ccgactcgtc ggacccaacg gcgaacaggt
    12061 cgggatcgtc cgcatcgagg acgcgctccg c
//
