LOCUS       NZ_JAMTCR010000002     10804 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinokineospora globicatena strain DSM 44256
            LV79DRAFT_scaffold00001.1, whole genome shotgun sequence.
ACCESSION   NZ_JAMTCR010000002
VERSION     NZ_JAMTCR010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora globicatena
  ORGANISM  Actinokineospora globicatena
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 3058629)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3058629)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3058629)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2022) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
REFERENCE   4  (bases 1 to 3058629)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2022) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: AllPaths v. r46652
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 261.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024171945.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:43:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,731
            CDSs (total)                      :: 6,666
            Genes (coding)                    :: 6,609
            CDSs (with protein)               :: 6,609
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 8 of 57
            Pseudo Genes (incomplete)         :: 49 of 57
            Pseudo Genes (internal stop)      :: 2 of 57
            Pseudo Genes (multiple problems)  :: 1 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:43:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2673082
            Orig. end                         :: 2683886
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAMTCR010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10804
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="9"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10804
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10804
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5804](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5804)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(1881..1895)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     gene            3508..4266
                     /locus_tag="LV79_RS12105"
                     /old_locus_tag="LV79_002362"
     CDS             3508..4266
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037170.5"
                     /locus_tag="LV79_RS12105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002362"
                     /product="VOC family protein"
                     /protein_id="WP_253835089.1"
                     /transl_table=11
                     /translation="MVTRPTAWPVGTPCWIDLGADVERAAAFYSALFGWRVEIGPAEFG
                     GYANCYVGEHPVAGLGPLQEGQVSAWVTYLSTEDVETSAAAIGAAGGQVVVPPMPIGGL
                     GAMTAGVDPVGAFFALWQSGTHTGTNLTGEPGSIVWADHLSDDPEAAKAFYGSLLGHTH
                     REVRPDPHYSTVHLGDDDEPVAGLGTAAAGTPPRWTVYFEVEDADAAVAKVIELGGTVQ
                     EGLTDTPHGRQAVVTDDQGARFVVNTSPKS"
     gene            complement(4672..5004)
                     /locus_tag="LV79_RS12110"
                     /old_locus_tag="LV79_002364"
     CDS             complement(4672..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684641.1"
                     /locus_tag="LV79_RS12110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002364"
                     /product="hypothetical protein"
                     /protein_id="WP_253835091.1"
                     /transl_table=11
                     /translation="MSREEVAAAQGELLRSLLAGGSPPAGFDPGAIRVEAAALLGKRRR
                     IVREIDPGTAEELGDRFAELFAEYALANPRRDGSRFREDAVAFAAWATERGHLRRARRR
                     WWRRSG"
     gene            complement(5001..5804)
                     /locus_tag="LV79_RS12115"
                     /old_locus_tag="LV79_002365"
     CDS             complement(5001..5804)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224517.1"
                     /locus_tag="LV79_RS12115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002365"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_253835093.1"
                     /sec_met_domain="DUF692 (E-value: 7.7e-82, bitscore: 271.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEHLGVGIGWRSEIDLTVERMQGVDFVEVVAENIHRDHLPESLR
                     VLRARGLPVLPHAVSLSLGGAEPLDTDRVEHLAAVADLLDAPLVSDHVCFVRAGGLDSG
                     HLMPVPRTRDALEVLVANVTQARSILGRPLALENIAALLEWPNAELTEARFLRELVERT
                     DCLLLVDVANMWANAKNLGADPVELLDGIPLERLAYVHVAGGVEVDGVYHDTHAHAVPQ
                     GVLDLLGELCSRVRPPGVLLERDDRYPSDAVLADELAAIRAVVAA"
     gene            complement(5854..6759)
                     /locus_tag="LV79_RS12120"
                     /old_locus_tag="LV79_002366"
     CDS             complement(5854..6759)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="LV79_RS12120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002366"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_253835095.1"
                     /transl_table=11
                     /translation="MDRAWGVAGPDFLRLYLVAIAFAALLAAAVRIKARGGRDSGGERL
                     SVEEVAYLAGGARRVVELAITRLLDKGKLRATRDGRLSVVAGGEGKGKGERDDEVDAAV
                     LRVIEQRAHRWPGVLISAVAGRGVVTAIGESLARRGLVVDQRRRWSRRSALPMAVVAVL
                     GVVRWASEVGGSGPGWLTAAVIAAMGLTALIAAAAVPERTYAGDRVLRETRQARREGSP
                     LADHYVFSGSVGVVVFAGLAGHPDETVARFATASRTHSTADGSSSAHSVGCAGGGGHGH
                     GCGGGGGCGGGGGCGGGGGA"
     misc_feature    complement(6852..6867)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            complement(7015..7443)
                     /gene="msrB"
                     /locus_tag="LV79_RS12125"
                     /old_locus_tag="LV79_002367"
     CDS             complement(7015..7443)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645129.1"
                     /locus_tag="LV79_RS12125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002367"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_253835097.1"
                     /transl_table=11
                     /translation="MGREPVVGATPRVVRSEQEWRAQLSAKEFAVLRDAGTEPAWTGEY
                     TDTKTVGVYRCRACDAELFRSDTKFESHCGWPSFFSPLAGESIVLREDRAHGMVRTEVL
                     CASCHSHLGHVFEGEGYPTPTDQRYCINSISLTLVPDA"
     gene            complement(7481..7816)
                     /locus_tag="LV79_RS12130"
                     /old_locus_tag="LV79_002368"
     CDS             complement(7481..7816)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684637.1"
                     /locus_tag="LV79_RS12130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002368"
                     /product="hypothetical protein"
                     /protein_id="WP_253835099.1"
                     /transl_table=11
                     /translation="MAATGTFGDSEESDDAVRRARADRFHEDLVGLDPADPEAREFAEH
                     LDRVEQVRPSYTVEGYLGGVRDFAESANRLGGHYRLTAGILAGLILLGVVVAAWDALVF
                     IVGVLFG"
     gene            complement(7852..9105)
                     /gene="hisS"
                     /locus_tag="LV79_RS12135"
                     /old_locus_tag="LV79_002369"
     CDS             complement(7852..9105)
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684636.1"
                     /locus_tag="LV79_RS12135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002369"
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_253836029.1"
                     /transl_table=11
                     /translation="MDNSPARGTRDLLPATVAVRDHVLARITEVYHRYGYQRVETPALE
                     GIDRLTGGQGGENEKMIYRVLRRGLDETVAADTALADLVDLGLRYDLTVPLTRFYGANQ
                     ASLPQPFRSFQFGPVWRAERPQKGRYRQFNQCDIDMLGEESVLAEVELIEATTEALAAA
                     GLSGATVRVSDRRFLSALAASVGLPEEAWTGLFITLDKLDKIGWDGVRAELPSRGLDDA
                     AIDRLQESITGLQGGDPATLDKRLLEAVPGLPDEVVADLAETATALAAVAGLAWEFDPT
                     LVRGMGYYTGQIFEITHPASTSAIAGGGRYDKLIGRSLGRDVPACGFSIGFERIVDLVD
                     GAKTTDAVAVLYEADVPLPVVTATARELRQGGRTASPVRRRGKFGAQLGKLEEWGFTAV
                     VHVKDAAAAPEERPLGGR"
     gene            9194..10234
                     /locus_tag="LV79_RS12140"
                     /old_locus_tag="LV79_002370"
     CDS             9194..10234
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684635.1"
                     /locus_tag="LV79_RS12140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LV79_002370"
                     /product="DNA polymerase domain-containing protein"
                     /protein_id="WP_253835101.1"
                     /transl_table=11
                     /translation="MAPAVEIEVDGRSVRVSNPDKPYFAELGVVKRQVVEYFLAVGPGI
                     LGALRERPTTLERWPGGVFEGAKLSTRADHTGDAFYQKRLPKGAPDYVESARITFPSGR
                     PADEVCPTELAVVAWAANLGTLTFHPWPVSRADVDHPDQLRVDLDPQPGTDFTDAVAIA
                     HEARDLLRALDMDAFPKTSGGRGVHLYIPIEPRWTFVEARRAVIALARELERRMPERVT
                     VNWWKEERGSRVFIDYNQMARDRTIASAYSIRPTPRALVSAPVTWDELSSVHPEDFSVL
                     TMPARFAEVGDLHAAVAHHAYSLDALLEMSARDERDHDLGDLPYPPEYPKMAGEPKRVQ
                     PSKARD"
ORIGIN
        1 gcgcttggag atcaggtagg cgcggatgat ggtttgggtg gtggtgccgc ctcggccgtc
       61 ggtggcttgg gcttggaggg agactgaggt ggcgttgcgg gggtggtcca ggaggaggtc
      121 tgtgccgcgg aggtgggcct tgcgccaggt tttgccctcg tcgtacgaga cgttgacgga
      181 caggttgcgg ggggtgatgt gggtgccgtt ctccagttgg agggataccg ggatggtgaa
      241 cttgcctgcg ggggcggagt tgtcgtcgcg caggggggcg ttgaagcgca ctgtggacag
      301 tgggatcgcc tgctggcgcg ggtcggagcg gaaggtccac gcggcggcga tcttggtgct
      361 gacgccgaag gcggggtcgc gggtggcttc ggtttccagg cggtagtcgg cggccgcctc
      421 ggggacgggg aagatgccgc cgcccggggt gggggattcg ccgatcttct tgccgttgcg
      481 gaagagcgtg gtcttcgcgg aggtcgtgtt gctgaagccc gcgttgccgc cgctgtcgcc
      541 ccagaggccg atgttgatcc cgaaggtgtt gttccagcgc tcggcccacg ggatcacgct
      601 gcggggcagg gcggggccga acacgccgtg gttcgtgcgc gtgcggtagg tctgcccggc
      661 cttggtgcgc accggttcgc tggtgaacac cgtgtcgacc gactcctggt cggggcggcc
      721 gatgaacacg tcgccctgcc actggacgcc gcccgcgttg acgtactcga cgacctcgcc
      781 gccctcgaag gcgcggccgg tgctgacggt gatgccccgc ccgtccagcg agtacgggta
      841 cagcgcccgc ccggcgttcg acccgggcag ccccggtccg accttggtgc gcagcgtggc
      901 cacgtcaccg cgccgcacga cccgggtgaa cccggtgggc acggacttct cctggtacca
      961 ggcgaagttg tagaagtcgc ccgtgttggt cacgtcgtcg tagtagaccg ccgccagcgc
     1021 ccagatgagc acgttcgcgg gcagctccgg cccgatctgg ccgatgccga acccatcgaa
     1081 cagcggtccg gcgatcccga gcccgaagcg ccgaccgccg atcggggaca gctcgtagcc
     1141 cgaggacgcc acccacagcg ggacccgcgg gtccggcggc gtgacccgca ccggcttggt
     1201 cttgcgggcg tcgaccacga cctcggtcgc gcccttcacc tcgaaggccg ggtacggcag
     1261 gctccgcacg tcgggcttct cgccggtcgt cgcgtacacg ctgtcgagca cgtacgcgcc
     1321 cttgggcagg cgcaccgtcg ccacgcccga ggcgtccggc gtcgcgccgc cgaagtagtc
     1381 ggagtacagg ccgatggcca gcgtccgcca gtcagtgctc ggcttgccgt ccgggcccag
     1441 gtaccgcagc cgcacgtcgt agctctccac ctcgcggtcg agcgcgaccg gggtgctcag
     1501 cgactgcccg ccgccggtgg cggtgacggc gccggagtag ccgccgtcga gggtgccgag
     1561 ccgggagtca ccggtgacct tggccgtggc ggtcccgccc gcgggcacgg tcagcttggc
     1621 gggggtgacg ctgaagaacc cggcgggcgc gggcttgccg tccggtccgg tgccggtgac
     1681 cgcgaggtcc agcgccaccg gtgccgacga ggtgttgcgg taggtcaggt ccttggtgac
     1741 cgcggtgtcg tcgttgtgcg gccactgcag ggtgccgagg ctgaccgagg tgggctgggt
     1801 ggtcagcgcc tgggtgagcg ccttggccac gtcgacccgg ccggagccct gggcgaacac
     1861 cgactcgccc gcggtgggtt tggccgaggc ggtcaggacc gccttgagct gcgccccggt
     1921 ccactccggg tgctgctggg ccagcagcgc ggctgccccg gcgacgtgcg gcgcggccat
     1981 cgaggtgccc gagagcccca cgtaaccggg ctcgaccggg tcgccgatga ccccgttggc
     2041 ggccttcgcg gccacgatgc cggacccggg cgcggtgacg tccggtttga tcgcgccgtc
     2101 gccgacccgc gggccgcggc tggagaagaa cgacaccgtg tcgtcgcgct cgaccgagcc
     2161 gacggtcagc gccgcgtccg cgcttccggg ggtgccgacc gattggctgg acggcccgga
     2221 gttgcccgcg gagacgacga acagcgtccc gcgctcggcg gtgagccggt tgacggtctc
     2281 ctccagcggg tcgacctcgg gggtgtcgct cgcgccgagg ctgaggttca ccaccttcgc
     2341 cccggagtcc accgcccact cgacgcccgc gatgatccac gacagctgcc cgccgtcgcg
     2401 gctgagcgcc ttggcgtcga gcaccttcgc gccgttggcg acaccccggt acttggcgcc
     2461 gccgcccgcg acgatcgagg cgacgtgcgt gccgtgcccg acgacgtcct cggcgctcgg
     2521 gtcgtcggtg aagttgcgct cgccgacctc ccggcccgcc aggtccgggt gcgtctggtc
     2581 gatgccggtg tcgacgacgc cgaccgtgac gcccgcgccg gtgagcccgg cctgccacgc
     2641 cgccggggcg ccgatctgcg ctgtgctgcg gtccagggag gcttccacct tgcggtcgag
     2701 ccacaccttg ccgcccgcgg ctgtcaacgc gcgccacgag tccggtagcg ctgccttgtc
     2761 ggcggagagc gcgcgggcgc ccgcgaccgg cagttctcgc accgaacgca cgcctgccgc
     2821 gcgggtgctc gggccggtct ggatcagcgg caggtccgcg cgcctgtcgt cgtagcccgc
     2881 cttggcgagg cccgcgacgt cgaacaggtc gcggtccagc ctgccggaga gcaccagcgg
     2941 catcgcgtcg gacgggaaga cgtagttgtg ctcgccgcgg gtgtaggtct ggaagacgat
     3001 cccggcgcgg cgcttgtccg gcaggatcgc cgttctcgtc ccgccgcgcg cgtcggcgct
     3061 gacgcgcacc ttgtcgccgg tcaggagcgt gacggtggtg gccggtccgg tctgccgcag
     3121 gccttgcccg gcgggagcgg ccgccgcctg cggtgcgacc gcgagcgcca agccgaggac
     3181 gagcgttgtc gaggtgaatg ctgctgtggt gcggattcgc atggagtacc ccggtccttg
     3241 ctcggagaag gggaacactg aagggccgtc gacacggctg tggaaaagga atgtcgaacg
     3301 aaaggcccca gtgcggaaga agctatccag ccccgctcgg cgatcgcaat ccgccaagtg
     3361 actgatcgat ccgaccgcgc ggcgcaccag gggttcccac ccctcgggaa cggtccacag
     3421 gcgacagcgt ggtgcgccac cggtccccgg ggttagcgtt gcgccatccg cacgtcccgg
     3481 cggagcgcga ctaccaggag gtatcccatg gtcacccgtc ccaccgcatg gccggtaggc
     3541 accccgtgct ggatcgacct cggcgccgac gtcgagcggg cagccgcgtt ctactcggcg
     3601 ctgttcggct ggcgggtcga gatcgggcct gcggagttcg gcgggtacgc gaactgctac
     3661 gtcggcgaac acccggtcgc aggcctcggt ccgctgcagg agggccaggt cagcgcctgg
     3721 gtcacctatc tgtccactga ggacgtcgag acgagcgcgg cggccatcgg ggcggcgggc
     3781 ggccaggtgg tcgtcccacc gatgcccatc ggcggcctcg gtgcgatgac cgccggggtc
     3841 gacccggtcg gggcgttctt cgcgctctgg cagtcgggca cgcacaccgg caccaacctc
     3901 accggcgagc cgggctcgat cgtctgggcc gaccacctca gcgacgaccc cgaggccgcg
     3961 aaagccttct acggcagcct tctcggccac acccaccgcg aggtccggcc cgatccgcac
     4021 tacagcaccg tgcacctggg cgacgacgac gagccggtcg ccggactcgg taccgccgcc
     4081 gcgggaaccc caccgcgctg gacggtgtac ttcgaggtgg aggacgccga cgcggccgtg
     4141 gccaaggtca tcgagctggg cggcaccgtg caagaggggt tgaccgacac ccctcacggc
     4201 aggcaggcgg tggtgaccga cgaccagggt gcgcgtttcg tggtgaacac ctcgcccaag
     4261 tcctgaccgg gacgcgggag cgggtggcgg ccgttccccc agtagcggtg gcctccgcct
     4321 ccccagtcca ggaccggcgg tggcgcggtg tcaccgggtg cccgagtcgg tccaggggag
     4381 ggggctcgat gagcaggtgg atcggttgcc gtataacggt ttccgggcag gcggtgccac
     4441 gaagacaagt ggtctggtcc agctcggcga tgttgccgcg gcgcgacccg ctgccgtggg
     4501 cgttcgccgt ggtcgtctgc accacgttct ccgggcggtc ccggtgatcg gaccgccccg
     4561 ctcgaccacc ccgtggtggg ggagcgcgtc accacaccgc tgggcggcag gggtccggcg
     4621 gctgcggtga cccgcccggc ctggtggcgc ccccgagcac caccaggccg gtcacccgga
     4681 ccgccgccac cagcggcggc gcgcgcggcg caggtgcccg cgctcggtcg cccaggccgc
     4741 gaacgcgacc gcgtcctcgc ggaatcgcga cccgtcccgg cgcggattgg ccagcgcgta
     4801 ttcggcgaac agctcagcga accgatcacc gagttcctcg gccgttcccg gatcgatttc
     4861 ccgcacgatc cgccgccttt tccccaaaag cgcggcggcc tccacccgaa tggcaccggg
     4921 gtcgaacccg gcgggtggac tgccaccggc caacaaggac cgcagcaatt cgccctgggc
     4981 ggcggccacc tcttcgcggc tcacgcggcc accacggcgc ggatcgcggc gagctcgtcg
     5041 gccagcaccg cgtccgacgg gtaccggtcg tcgcgctcca gcagcacccc cggcggccgg
     5101 acccgcgaac acagctcccc gagcaggtcg agcacgccct ggggcaccgc gtgggcgtgc
     5161 gtgtcgtggt agaccccgtc gacctcgacc ccgcccgcca cgtgcacgta ggccaggcgc
     5221 tccagcggga tcccgtcgag cagctcgacc gggtcggcgc ccaggttctt cgcgttggcc
     5281 cacatgttcg ccacgtcgac cagcagcagg cagtcggtgc gctcgaccag ctcccgcagg
     5341 aaccgcgcct cggtcagctc cgcgttcggc cactccagca gcgcggcgat gttctccagc
     5401 gccagcggcc tgcccaggat cgaccgcgcc tgggtcacgt tggccaccag cacctccagc
     5461 gcgtcgcggg tgcgcggcac cggcatcagg tgcccggagt cgagcccgcc cgcccgcacg
     5521 aagcacacgt ggtcgctcac cagcggcgcg tccagcaggt cggccaccgc ggccaggtgc
     5581 tcgacccggt cggtgtcgag cggctcggcg ccgcccaacg acaaggagac ggcatggggg
     5641 agcaccggga gccccctcgc gcgcagcacg cgcagtgact ccgggaggtg gtcgcggtgg
     5701 atgttctccg cgacgacctc gacgaagtcg accccctgca tccgctcgac ggtcagatcg
     5761 atctccgacc gccagccgat gcccactccc aagtgctcac ccatgccgcc atcctccccc
     5821 ctgtccccct cttatctccc caccccgggg cgtctaggca cctccaccac ccccgcagcc
     5881 cccgccgcct ccgcagcccc cgccgccacc gcagccgtgc ccgtggccgc cgccgcccgc
     5941 gcagcccacc gagtgcgctg acgaggagcc gtccgcggtg ctgtgcgtgc gggacgccgt
     6001 cgcgaagcgg gcgaccgtct cgtccgggtg cccggccaga cccgcgaaca cgaccacccc
     6061 gacggacccg ctgaacacgt agtggtcggc cagcgggctc ccctcccgcc tggcctgcct
     6121 ggtctcccgc aggacccggt caccggcgta ggtccgctcc ggcaccgccg ccgccgcgat
     6181 gagcgcggtc agccccatcg ccgcgatgac cgccgcggtg agccagccag ggccggagcc
     6241 accgacctcg ctcgcccagc gcaccacccc gagcacggcc acgaccgcca tcggcagcgc
     6301 cgagcgccgc gaccaccgcc gccgctggtc gacgacgagc cccctgcggg ccaggctctc
     6361 gccgatcgcg gtcaccacgc cccgacccgc gaccgccgag atcagcactc ccggccaccg
     6421 gtgcgcgcgc tgctcgatca cccgcagcac cgcggcgtcg acctcgtcat cgcgctcgcc
     6481 cttgcccttg ccctcgccgc ccgcgacgac cgacaaccgc ccgtcgcggg tggcccgcag
     6541 cttccccttg tccagcaacc tggtgatggc gagttcgacc acccgccggg caccgcccgc
     6601 gaggtaggcc acctcctcca cgctcagccg ctccccaccg ctgtccctgc cgccgcgggc
     6661 cttgatccgc acggccgcgg cgagcagcgc cgcgaacgcg atcgcgacca ggtacaaccg
     6721 aaggaagtca ggtcccgcga caccccatgc tcgatccatc tctccccctg ccccagagga
     6781 gcgcccaccc gcggctttcc cctgtgtccc accgggtttc cgctcccggt cgagacccat
     6841 gctcggggtg ctgtgaccgg gcgcacaagc gggcttgagc aagatttagg ggtaccgggg
     6901 gctggattta ggcttcttga cgtggccttg atgtgacccg gcggtagggg taggacgact
     6961 ccgccccgcc gggcaggact acctgcgcga cggggcggag tcgaacggcc gacctcaggc
     7021 gtcgggcacc agggtcagcg agatcgagtt gatgcagtag cgctggtcgg tcggcgtcgg
     7081 gtagccctca ccctcgaaga cgtgccccag gtggctgtgg cagctcgcgc acagcacctc
     7141 ggtgcgcacc atcccgtgcg cgcggtcctc gcgcagcacg atgctctccc cggccagcgg
     7201 tgagaagaac gacggccacc cgcagtgcga ctcgaacttg gtgtcactgc ggaacaactc
     7261 cgcgtcgcac gcccggcacc ggtacacccc gacggtcttg gtgtcggtgt actcaccggt
     7321 ccacgccggt tcggtgcccg cgtcgcgcag caccgcgaac tccttggcgg agagctgcgc
     7381 gcgccactcc tgctcggacc tgaccacgcg cggtgtcgcg ccgaccaccg gttccctacc
     7441 cacgtccgcg ttcactcctc ggttctgcgg ctgatggtgc tcagccgaac aggacgccca
     7501 cgatgaacac cagcgcgtcc cacgcggcca ccaccactcc caacaagatg aggcccgcga
     7561 gtatgcccgc ggtgagccgg tagtgaccgc cgagccggtt ggccgactcg gcgaagtcac
     7621 gcaccccgcc caggtacccc tcgacggtgt agctcggccg cacctgctcc acccggtcca
     7681 ggtgctcggc gaactcgcgc gcctccggat cggccgggtc cagcccgacc aggtcctcgt
     7741 ggaaccggtc cgcacgggcg cggcggaccg cgtcatcgga ctcctccgag tccccgaacg
     7801 ttcctgtcgc ggccatgcgt ccacggtaac ccggaggtcc agtgatccgg cttacctccc
     7861 gccgagcgga cgctcctccg gtgccgccgc cgcgtccttg acgtgcacga cggccgtgaa
     7921 gccccactcc tccagcttgc ccagctgcgc gccgaacttg ccccgcctgc gcaccggcga
     7981 cgctgtgcgg ccgccctggc gcagctcgcg ggctgtcgcg gtgaccacgg gcagtggcac
     8041 gtcggcttcg tagagcaccg ccacggcgtc ggtggtcttg gcgccgtcga ccaggtcgac
     8101 gatccgctcg aagccgatcg agaacccgca ggcgggcacg tcgcggccga gggagcggcc
     8161 gatgagcttg tcgtagcggc cgccgcccgc gatggcgctc gtgctcgccg ggtgggtgat
     8221 ctcgaagatc tggccggtgt agtagcccat gccgcgcacc agggtcgggt cgaactccca
     8281 ggccagcccg gccacggcgg ccagcgcggt cgcggtctcg gccaggtcgg cgacgacctc
     8341 gtccggcagc ccggggacgg cctcgagcag ccgcttgtcc agcgtcgccg ggtcgccgcc
     8401 ctgcaggccg gtgatgctct cctgcagccg gtcgatcgcg gcgtcgtcga ggccccggct
     8461 gggcagctcg gcgcgcaccc cgtcccagcc gatcttgtcg agcttgtcca gggtgatgaa
     8521 caggccggtc cacgcctctt cgggcagccc gaccgaggcg gccagcgcgg acaggaaccg
     8581 ccggtccgac acccgcacgg tcgcgccgct caggcccgcc gcggccagcg cctcggtggt
     8641 cgcctcgatc agctcgacct cggcgagcac gctctcctcg ccgagcatgt cgatgtcgca
     8701 ctggttgaac tggcggtagc ggcccttctg cggccgctcc gcgcgccaga ccgggccgaa
     8761 ctggaacgac cggaacggct gcggcaggct cgcctggttc gcgccgtaga accgggtcag
     8821 cgggacggtc aggtcgtagc gcaggcccag gtccaccagg tcggccagcg cggtgtcggc
     8881 ggcgacggtc tcgtcgaggc cgcggcgcag cacccggtag atcatcttct cgttctcgcc
     8941 gccctggccg ccggtgagcc ggtcgatgcc ctccagggcc ggggtctcca cgcgctggta
     9001 gccgtaccgg tggtagacct cggtgatcct cgccagcacg tggtcgcgca ccgcgacggt
     9061 cgcgggcagc aggtcacggg tgcccctggc ggggctgttg tccatcttca ccgggtgcgg
     9121 tccttcgctg tcgtggtgcg accacggtac cgagccgcgc gcgcggtttt ccggccgccc
     9181 gtaggctggc gccatggcgc cagcggtgga gatcgaggtc gacggccgga gcgtgcgggt
     9241 gtccaatccg gacaagccgt acttcgccga gctgggcgtc gtcaagcggc aggtggtcga
     9301 gtacttcctc gcggtcggcc ccggcatcct cggtgcgctg cgcgagcggc cgaccacgct
     9361 ggagcgctgg cccggcgggg tgttcgaggg cgccaagctc tccacccgcg ccgaccacac
     9421 cggcgacgcg ttctaccaga agcggctgcc caagggcgcc cccgactacg tcgagtccgc
     9481 caggatcacc ttccccagcg gccgccccgc cgacgaggtc tgcccgacgg aactggcggt
     9541 cgtcgcctgg gccgccaacc tgggcacgct gaccttccac ccgtggccgg tctcccgcgc
     9601 cgacgtcgac caccccgacc agttgcgcgt cgacctcgac ccccagcccg gcaccgactt
     9661 caccgacgcc gtcgccatcg cgcacgaggc cagggacctg ctgcgcgcac tggacatgga
     9721 cgccttcccc aagacctccg gcggccgcgg cgtgcacctc tacatcccga tcgaaccgcg
     9781 ctggaccttc gtcgaggccc gccgcgcggt gatcgccctg gcccgcgaac tggagcgccg
     9841 catgccggag cgggtcacgg tgaactggtg gaaggaggaa cgcggcagcc gggtgttcat
     9901 cgactacaac cagatggccc gcgaccgcac catcgcctcc gcctactcga tccgccccac
     9961 tccgcgcgcc ctcgtctccg ccccggtgac ctgggacgaa ctcagctcgg tgcaccccga
    10021 ggacttcagc gtcctcacca tgcccgcccg cttcgccgag gtcggcgacc tgcacgccgc
    10081 cgtcgcccac cacgcctact ccctggacgc gctcctggag atgtcggccc gcgacgaacg
    10141 cgaccacgac ctgggcgacc tcccttatcc ccctgagtac cccaaaatgg caggcgaacc
    10201 caagcgcgtc caaccctcca aagcccgcga ctgacccagc ccgcgactga cccagcccgc
    10261 gactgaccca gcccgcgact gacccagccc gcgactgacc cagcccgcga ctgacccggc
    10321 ccgcgatcga cccggcccgc gatcgacccg gcgaagatcg actggcccgc cttgcggtca
    10381 cccccagccg cgatcgactg acctcgcgat cacgtcggcc cggctgctga ccgacctcgc
    10441 ggttggcccg cctcgcgagc tgatccgcac ccggctgacc tggcccacgc ccgatccgct
    10501 cgcgggtggg ctgcctcgcg gtcaccccag ccgcttccag cccggttcgc ggctggaacc
    10561 ggggcggtgg cccgagtccc gtcccgtggt cgacgcgcgg cgggggcggt cggttcggtc
    10621 gcgatcggcg taacggcggt agcggtcgtg gcgacctctc ccgtgacctc gctggttccg
    10681 gacacgtcgg taccgggggt cggcgcggct ggatcggttc cagcggcggc gatgcggcgg
    10741 tcgtggcggc ggtcgcgcgg gtcgggtggt gtcggtcgct gacggggcgt tccactgtgg
    10801 ccgt
//
