MIBiG Protein Description MIBiG Cluster MiBiG Product % ID % Coverage BLAST Score E-value
ABS75820.1 BacC BGC0001184.4 other:other 99.0 100.0 496.0 1.89e-180
ACX35428.1 BacC BGC0000888.5 other:other 97.0 100.0 488.0 2.12e-177
ACM68692.1 putative_oxidoreductase BGC0000298.5 NRPS:Type I 38.0 100.8 166.0 2.92e-50
ABS74183.1 YxjF BGC0001090.5 NRPS:Type I+PKS 36.0 104.0 156.0 1.24e-46
BAB69696.1 BGC0001098.5 NRPS:Type I+PKS 36.0 104.0 156.0 1.76e-46
ABX71095.1 Lct12 BGC0000238.5 PKS 36.0 100.0 154.0 7.07e-46
WP_035850920.1 glucose_1-dehydrogenase BGC0002536.3 NRPS:Type I 38.0 101.2 151.0 1.45e-44
BAF14087.1 BGC0000671.3 terpene 37.0 99.6 145.0 2.63e-42
BAW27709.1 dehydrogenase BGC0001764.4 NRPS:Type I 37.0 97.2 144.0 4.73e-42
ANY57970.1 Short_chain_dehydrogenase BGC0001369.3 PKS 34.0 101.2 144.0 7.21e-42
BAF14088.1 BGC0000671.3 terpene 37.0 99.2 143.0 2.05e-41
QBA57739.1 NAD(P)-dependent_oxidoreductase BGC0002377.2 NRPS:Type I 34.0 108.3 143.0 2.05e-41
CAP93735.1 BGC0001882.3 PKS 36.0 105.5 141.0 1.05e-40
EEF48747.1 short_chain_alcohol_dehydrogenase,_putative BGC0002393.2 terpene 33.0 100.8 141.0 1.42e-40
CAP12610.1 dehydrogenase BGC0000219.4 PKS:Type II+saccharide:hybrid/tailoring 36.0 101.6 140.0 2.22e-40
ALG65315.1 Cal21 BGC0001297.4 NRPS:Type I 34.0 108.3 140.0 3.24e-40
ABP73642.1 SalM BGC0000145.5 NRPS:Type I+PKS 37.0 100.0 139.0 3.87e-40
ABP53501.1 short-chain_dehydrogenase/reductase_SDR BGC0001041.4 NRPS:Type I+PKS 37.0 100.0 139.0 3.87e-40
ARF06204.1 short-chain_dehydrogenase/reductase_SDR BGC0001593.5 NRPS:Type I 34.0 96.4 138.0 1e-39
CBG67532.1 putative_oxidoreductase BGC0002367.2 NRPS:Type I 33.0 107.5 139.0 1.24e-39
AAN85505.1 short-chain_dehydrogenase/reductase BGC0001101.5 NRPS:Type I+PKS:Type I 31.0 109.5 138.0 1.83e-39
ADB23395.1 dehydrogenase BGC0001062.5 PKS 37.0 99.2 137.0 1.83e-39
ACO31295.1 PtmO8 BGC0001140.5 terpene:Diterpene 33.0 103.6 138.0 2.71e-39
CAI94720.1 putative_oxyacyl-(acyl_carrier_protein)_reductase BGC0000141.5 PKS 34.0 98.0 136.0 5.12e-39
ADD83006.1 PtnO8 BGC0001156.5 terpene:Diterpene 32.0 103.6 137.0 5.36e-39
BAE60009.1 BGC0001518.3 terpene 36.0 100.0 136.0 6.96e-39
AEG64681.1 2-deoxy-D-gluconate_3-dehydrogenase BGC0000379.5 NRPS:Type I 34.0 102.8 137.0 7.92e-39
SEG87404.1 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family BGC0002712.2 PKS 33.0 103.6 136.0 1.14e-38
QCX41951.1 Amc14 BGC0001957.4 PKS 34.0 97.6 135.0 1.26e-38
QHW08548.1 SDR_family_oxidoreductase BGC0002054.2 PKS+NRPS:Type I+saccharide 34.0 97.6 135.0 1.26e-38
ABW11827.1 short-chain_dehydrogenase/reductase_SDR BGC0001197.5 PKS 35.0 99.6 133.0 7.14e-38
CAA74346.1 oxidoreductase BGC0000507.5 ribosomal:RiPP:Lanthipeptide 34.0 99.2 133.0 7.51e-38
EYE95337.1 NAD(P)-binding_protein BGC0002234.3 PKS 37.0 108.3 138.0 8.49e-38
CAM34370.1 putative_3-oxoacyl-ACP_reductase BGC0000242.5 PKS 34.0 98.8 131.0 3.94e-37
QBG38776.1 Atr15 BGC0001975.4 NRPS:Type I 31.0 100.8 131.0 4.26e-37
WP_029025960.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0000198.5 PKS:Type II+saccharide:hybrid/tailoring 34.0 98.4 131.0 5.01e-37
AMK51287.1 Hex30 BGC0001376.5 PKS 34.0 99.6 129.0 2.18e-36
AAQ08926.1 putative_3-ketoacyl-ACP_reductase BGC0000224.4 PKS:Type II 34.0 100.0 129.0 3.39e-36
AHX24706.1 3-oxoacyl-ACP_reductase BGC0000200.5 PKS:Type II+saccharide:hybrid/tailoring 32.0 100.0 128.0 1.01e-35
QNH67547.1 Cip19 BGC0002108.3 NRPS:Type I 31.0 100.8 127.0 1.82e-35
AMX23331.1 putative_acyl_carrier_protein BGC0001500.3 PKS 32.0 100.4 127.0 2.37e-35
ACZ87047.1 short-chain_dehydrogenase/reductase_SDR BGC0002732.3 PKS 34.0 99.6 127.0 2.37e-35
QCX41922.1 Mhr16 BGC0001956.3 PKS 34.0 101.2 125.0 6.43e-35
QHD26308.1 SDR_family_oxidoreductase BGC0002479.3 PKS+NRPS:Type I+saccharide 34.0 101.2 125.0 6.43e-35
CAM34340.1 putative_3-oxoacyl-ACP_reductase BGC0000242.5 PKS 33.0 99.6 125.0 7.46e-35
QBQ12474.1 SDR_family_oxidoreductase BGC0002693.2 NRPS:Type I 33.0 102.8 126.0 7.8e-35
WP_099111428.1 SDR_family_oxidoreductase BGC0001826.3 NRPS:Type I 35.0 99.6 125.0 9.97e-35
CEO59270.1 Putative_2-deoxy-D-gluconate_3-dehydrogenase BGC0002278.3 other:other+NRPS:Type I 33.0 104.7 124.0 4.16e-34
ABS75236.1 DhbA BGC0001185.5 NRPS:Type I 30.0 101.6 124.0 4.73e-34
ATJ00769.1 C-7_ketoreductase BGC0001568.5 PKS 34.0 99.2 123.0 5.48e-34
PVC99863.1 3-oxoacyl-ACP_reductase_FabG BGC0002100.2 NRPS:Type I+other:other 31.0 100.0 123.0 5.48e-34
ABY83162.1 Azi24 BGC0000960.5 NRPS:Type I+PKS 31.0 107.5 123.0 9.65e-34
CAM58804.1 BenL_protein BGC0000204.5 PKS:Type II 32.0 101.6 122.0 1.11e-33
ADE22321.1 3-oxoacyl-ACP_reductase BGC0000279.5 PKS 31.0 99.2 122.0 2.29e-33
KAA1470690.1 acetoin_reductase_family_protein BGC0002218.2 terpene 35.0 101.2 122.0 2.41e-33
ADB23387.1 dehydrogenase BGC0001062.5 PKS 35.0 101.2 121.0 2.79e-33
AWM95785.1 short_chain_dehydrogenase BGC0001827.3 PKS 33.0 98.4 121.0 3.07e-33
AMK51286.1 Hex29 BGC0001376.5 PKS 32.0 97.6 121.0 4.01e-33
AHL46681.1 ketoreductase BGC0001177.4 PKS:Type II 32.0 98.4 121.0 4.21e-33
ADE22311.1 putative_3-oxoacyl-ACP_reductase BGC0000279.5 PKS 31.0 100.8 120.0 6.2e-33
QED93108.1 short-chain_dehydrogenase/reductase_SDR BGC0002556.2 other:other 33.0 100.8 120.0 6.2e-33
EAU36095.1 predicted_protein BGC0002273.2 NRPS:Type I 32.0 108.3 121.0 6.28e-33
BAC16760.1 probable_2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase_protein BGC0002474.2 NRPS:Type I 32.0 99.2 120.0 6.35e-33
ABM21753.1 PdmG BGC0000256.3 PKS 30.0 99.6 119.0 1.56e-32
ADE34491.1 SsfU BGC0000269.5 PKS:Type II+saccharide:hybrid/tailoring 31.0 101.6 119.0 2.22e-32
CBK62720.1 BGC0001115.5 NRPS:Type I+PKS 32.0 99.2 119.0 2.73e-32
ACZ87049.1 short-chain_dehydrogenase/reductase_SDR BGC0002732.3 PKS 31.0 97.6 119.0 3.08e-32
AAL15603.1 SimJ1 BGC0000270.5 PKS 31.0 97.6 118.0 8.02e-32
AAK06807.1 putative_3-keto-acyl-reductase_SimD2 BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 31.0 97.6 118.0 8.02e-32
AQW35050.1 2,3-dihydroxybenzoate-2,3-dehydrogenase BGC0001675.5 PKS 29.0 98.0 118.0 8.4e-32
OKI81342.1 ketoacyl_reductase BGC0002478.3 PKS 32.0 103.2 117.0 2.37e-31
AHX24712.1 3-oxoacyl-ACP_reductase BGC0000200.5 PKS:Type II+saccharide:hybrid/tailoring 33.0 99.6 115.0 4.53e-31
ACN38371.1 short-chain_dehydrogenase/reductase BGC0000714.5 saccharide 31.0 103.6 115.0 6.36e-31
WP_037817190.1 3-oxoacyl-ACP_reductase_FabG BGC0002137.3 PKS 33.0 98.4 115.0 9.16e-31
ABL09970.1 oxidoreductase BGC0000197.5 PKS:Type II+saccharide:hybrid/tailoring 30.0 101.6 115.0 2.64e-30
WP_040253449.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0001596.3 PKS:Type II aromatic 31.0 100.8 113.0 5.29e-30
CBH32818.1 putative_ketoreductase BGC0000263.5 PKS 31.0 101.2 112.0 9.72e-30
BCJ07579.1 3-oxoacyl-ACP_reductase BGC0002379.3 NRPS:Type I 32.0 98.8 112.0 1.02e-29
AAA65202.1 daunorubicin-doxorubicin_polyketide_synthase BGC0000218.5 PKS 32.0 100.4 112.0 1.53e-29
CUX79054.1 3-oxoacyl-[acyl-carrier-protein]_reductase_FabG BGC0001715.4 NRPS:Type I 35.0 102.8 112.0 1.67e-29
BAB72043.1 AknA BGC0000191.5 PKS 31.0 100.8 112.0 1.91e-29
EDY42534.1 monensin_polyketide_synthase_ketoacyl_reductase BGC0000212.5 PKS:Type II 30.0 100.4 112.0 1.91e-29
BAO98807.1 putative_ketoreductase BGC0001002.5 NRPS:Type I+PKS 30.0 100.0 111.0 2.29e-29
BCP96887.1 short-chain_dehydrogenase BGC0002614.2 NRPS:Type I+PKS 31.0 101.2 111.0 2.34e-29
AAA65204.1 daunorubicin-doxorubicin_polyketide_synthase BGC0000218.5 PKS 31.0 100.8 111.0 2.67e-29
ACU36662.1 short-chain_dehydrogenase/reductase_SDR BGC0000392.5 NRPS:Type I 30.0 100.0 110.0 4.7e-29
CCH32748.1 Ketoreductase BGC0002070.3 PKS 31.0 100.0 110.0 5.01e-29
BAV17002.1 putative_ketoreductase BGC0001384.5 PKS 31.0 100.4 110.0 5.24e-29
WP_051892705.1 SDR_family_oxidoreductase BGC0001851.4 PKS:Type II aromatic 31.0 98.0 110.0 5.47e-29
BBG28485.1 short-chain_dehydrogenase/reductase_CdmF BGC0001926.3 PKS 31.0 100.8 110.0 6.58e-29
ABQ04140.1 short-chain_dehydrogenase/reductase_SDR BGC0000838.3 PKS 33.0 100.8 109.0 9.67e-29
ACM68688.1 AerF BGC0000298.5 NRPS:Type I 28.0 102.4 110.0 1.14e-28
WP_031147019.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0001851.4 PKS:Type II aromatic 31.0 101.2 109.0 1.44e-28
AAK57528.1 PgaD BGC0000262.5 PKS:Type II+saccharide:hybrid/tailoring 31.0 102.0 109.0 2.01e-28
BAX64254.1 ketoreductase BGC0001623.4 NRPS:Type I+PKS 31.0 97.6 108.0 2.6e-28
AVO00812.1 May13 BGC0001661.5 PKS 30.0 101.6 108.0 2.87e-28
CAC37883.1 putative_3-oxoacyl-[acyl-carrier_protein]_reductase BGC0000038.5 PKS:Type I 35.0 101.6 108.0 3.06e-28
OWA25242.1 ketoacyl_reductase BGC0001438.5 PKS+saccharide:hybrid/tailoring 32.0 100.4 108.0 3.85e-28
CAH10114.1 putative_ketoreducatse BGC0000268.5 PKS 31.0 102.4 108.0 4.37e-28
CCM44333.1 putative_3-oxoacyl-ACP_reductase BGC0001056.5 NRPS:Type I+PKS:Type I 33.0 98.8 108.0 4.85e-28
AAL15583.1 Sim5 BGC0000270.5 PKS 31.0 102.8 108.0 5.51e-28
AAK06787.1 putative_ketoreductase_SimA6 BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 31.0 102.8 108.0 5.51e-28
ABK36600.1 2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase BGC0001502.4 NRPS:Type I 33.0 100.0 107.0 5.96e-28
ACR12253.1 2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase BGC0000451.5 NRPS:Type I 31.0 100.4 107.0 6.78e-28
UPN68084.1 reductase BGC0002672.2 PKS 32.0 101.6 107.0 7.54e-28
ABP54645.1 short-chain_dehydrogenase/reductase_SDR BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 31.0 102.0 107.0 7.7e-28
AAO65349.1 putative_ketoreductase BGC0000236.5 PKS 29.0 104.3 107.0 1.08e-27
AQW35064.1 Polyketide_C-9_ketoreductase BGC0001675.5 PKS 31.0 99.6 107.0 1.1e-27
BCB17007.1 putative_3-hydroxybutyrate_dehydrogenase BGC0002523.2 NRPS:Type I 29.0 102.0 107.0 1.15e-27
ADC45556.1 2-hydroxycyclohexanecarboxyl-CoA_dehyrogenase BGC0000093.5 PKS:Type I 32.0 102.0 107.0 1.6e-27
TRO56980.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0002361.3 PKS+saccharide 31.0 100.8 107.0 1.67e-27
AEE65465.1 ketoreductase BGC0000223.5 PKS:Type II 32.0 102.8 106.0 2.06e-27
QTA30588.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0002143.2 PKS 30.0 104.0 106.0 2.11e-27
AAB36565.1 ketoreductase BGC0000234.5 PKS 29.0 100.4 106.0 2.24e-27
AAL24452.1 RdmJ BGC0000265.5 PKS 30.0 100.8 106.0 2.24e-27
AAK95835.1 putative_2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase_PhbA BGC0002495.2 NRPS:Type I 31.0 101.6 105.0 3.41e-27
CBJ82074.1 3-oxoacyl-[acyl-carrier-protein]_reductase_(3-ketoacyl-acyl_carrier_protein_reductase) BGC0001872.3 PKS 32.0 100.4 105.0 5.08e-27
QDQ37901.1 NADP+-dependent_oxidoreductase BGC0001979.4 PKS 32.0 96.4 105.0 5.64e-27
ADC45589.1 short-chain_dehydrogenase/reductase_SDR BGC0000093.5 PKS:Type I 31.0 76.3 105.0 5.76e-27
ATJ00771.1 ketoacyl_reductase BGC0001568.5 PKS 30.0 100.0 105.0 8.05e-27
ACI88864.1 AlnP_ketoreductase BGC0000195.5 PKS:Type II 32.0 99.6 105.0 8.39e-27
WP_030957358.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0001852.4 PKS:Type II+saccharide:hybrid/tailoring 30.0 101.2 104.0 1.13e-26
AXM42926.1 ketoacyl_reductase BGC0001940.3 PKS 31.0 100.0 104.0 1.22e-26
KGA48900.1 2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase BGC0002413.3 NRPS:Type I 29.0 101.6 104.0 1.28e-26
WP_018891732.1 3-oxoacyl-ACP_reductase_FabG BGC0001558.5 PKS 29.0 100.0 104.0 1.57e-26
CAC44199.1 ketoacyl_reductase BGC0000194.5 PKS:Type II aromatic 28.0 100.4 103.0 2.2e-26
QDG00823.1 polyketide_ketoreductase BGC0002028.4 PKS 28.0 102.4 103.0 3.01e-26
AGO50613.1 ketoreductase BGC0000229.5 PKS:Type II+saccharide:hybrid/tailoring 31.0 101.2 103.0 3.07e-26
AYU66237.1 TjhC3 BGC0002461.2 PKS 28.0 102.4 103.0 4.29e-26
AAX57194.1 auricin_polyketide_ketoreductase BGC0000201.5 PKS+saccharide:hybrid/tailoring 31.0 103.2 102.0 5.99e-26
ARO44671.1 ketoreductase BGC0001769.5 PKS 31.0 101.6 102.0 5.99e-26
MBW8699686.1 putative_ketoacyl_reductase BGC0002140.2 PKS 31.0 101.6 102.0 5.99e-26
BAL90266.1 putative_short-chain_dehydrogenase BGC0002021.3 PKS 29.0 98.4 102.0 6.15e-26
AAO39097.1 AdmC BGC0000956.5 NRPS:Type I+PKS:Type II 27.0 100.4 102.0 6.55e-26
BBA97253.1 putative_ketoreductase BGC0002383.3 PKS 28.0 100.8 101.0 1.63e-25
CBH32080.1 putative_polyketide_ketoreductase BGC0000211.5 PKS 30.0 102.8 101.0 2.28e-25
CAQ64702.1 probable_glucose_dehydrogenase BGC0000087.5 PKS 32.0 98.0 100.0 2.44e-25
CAA54861.1 ketoreductase BGC0000231.5 PKS 29.0 102.0 100.0 3.18e-25
QNL10616.1 Ketoacyl_reductase BGC0002514.3 PKS 29.0 100.0 100.0 4.43e-25
AAC73697.1 2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase BGC0002476.2 NRPS:Type I 30.0 100.4 100.0 4.77e-25
CAG14968.1 ketoreductase BGC0000253.4 PKS:Type II 30.0 101.6 100.0 6.07e-25
ARK36158.1 ketoacyl_reductase BGC0001723.5 PKS 30.0 101.6 100.0 6.07e-25
BAF98625.1 putative_2,3-dihydro-2,3-dihydroxy_benzoate_dehydrogenase BGC0000651.5 terpene 30.0 102.4 99.0 2.21e-24
AAD13539.1 reductase_homolog BGC0000239.5 PKS:Type II+saccharide:hybrid/tailoring 29.0 102.4 98.0 4.55e-24
AAZ23052.1 probable_dehydrogenase BGC0000291.5 NRPS:Type I 31.0 103.2 101.0 5.05e-24
AGH68923.1 oxidoreductase BGC0001083.5 PKS:Type III+terpene:Sesquiterpene 29.0 101.2 96.0 2.1e-23
AGC83587.1 short_chain_dehydrogenase BGC0000818.5 NRPS:Type I 29.0 106.3 96.0 4.11e-23
AUI41032.1 3-oxoacyl-(acyl-carrier_protein)_reductase BGC0001512.5 PKS 28.0 101.6 95.0 4.23e-23
AIG62141.1 isoepoxydon_dehydrogenase BGC0000120.5 PKS:Iterative type I 31.0 100.8 95.0 4.47e-23
QVQ68802.1 mmyTIII BGC0002129.4 PKS 31.0 96.8 95.0 5.26e-23
AMX23339.1 3-oxoacyl-acyl-carrier-protein_reductase_FabG BGC0001500.3 PKS 31.0 100.8 93.0 2.17e-22
AET79189.1 chanoclavine-I_dehydrogenase BGC0001241.4 terpene 32.0 79.4 93.0 2.43e-22
CCE30232.1 related_to_D-arabinitol_2-dehydrogenase BGC0002232.2 other:other 32.0 79.4 93.0 2.43e-22
EHK18437.1 hypothetical_protein BGC0002233.3 PKS 28.0 104.3 93.0 2.71e-22
AKT74300.1 TxnC4 BGC0002141.3 PKS 32.0 79.8 90.0 2.32e-21
ACH85578.1 CetF1 BGC0000283.4 other:cyclitol 29.0 104.0 89.0 6.32e-21
ABV57822.1 oxidoreductase BGC0001267.3 terpene 32.0 104.0 89.0 1.26e-20
ATJ34011.1 short-chain_dehydrogenase BGC0001442.5 NRPS:Type I 32.0 71.9 91.0 1.88e-20
BAC70704.1 1-deoxy-11beta-hydroxypentalenic_acid_dehydrogenase BGC0000678.5 terpene 30.0 76.7 87.0 3.9e-20
AXI91535.1 FunA5 BGC0001944.2 PKS 30.0 99.2 87.0 4.85e-20
MBE3200470.1 SDR_family_oxidoreductase BGC0002409.3 NRPS:Type I 35.0 67.2 87.0 4.94e-20
AAK57530.1 PgaM BGC0000262.5 PKS:Type II+saccharide:hybrid/tailoring 31.0 101.6 89.0 6.59e-20
CAG44632.1 SriL03.9 BGC0000712.5 saccharide 30.0 71.9 85.0 4.75e-19
QDG00821.1 oxygenase-reductase BGC0002028.4 PKS 29.0 102.4 83.0 1.13e-17
AAL15586.1 Sim8 BGC0000270.5 PKS 29.0 102.4 80.0 2.04e-17
AAK06790.1 putative_reductase_SimA9 BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 29.0 102.4 79.0 2.82e-17
MBW8699688.1 Anhydrotetracycline_monooxygenase BGC0002140.2 PKS 30.0 101.2 78.0 4.01e-16
AAX57196.2 auricin_polyketide_oxygenase-reductase BGC0000201.5 PKS+saccharide:hybrid/tailoring 29.0 101.2 78.0 4.2e-16
BAJ07846.1 putative_oxygenase-reductase BGC0000232.5 PKS 28.0 104.0 77.0 9.96e-16
ARO44645.1 monooxygenase BGC0001769.5 PKS 30.0 101.2 77.0 1.34e-15
QXL90830.1 3-oxoacyl-(acyl-carrier_protein)_reductase BGC0002426.3 NRPS:Type I 29.0 77.1 74.0 2.57e-15
AGO50615.1 oxygenase-reductase BGC0000229.5 PKS:Type II+saccharide:hybrid/tailoring 30.0 101.2 75.0 6e-15
ABP54641.1 short-chain_dehydrogenase/reductase_SDR BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 27.0 79.1 66.0 1.59e-12
CAP93751.1 BGC0001882.3 PKS 28.0 81.8 61.0 9.43e-11
PKX92295.1 putative_NADP(+)-dependent_dehydrogenase BGC0001988.3 PKS 27.0 83.8 49.0 1.2e-06