LOCUS       NZ_JAMYDW010000017     14568 bp    DNA     linear   CON 24-SEP-2024
DEFINITION  Bacillus subtilis strain X0416 contig17, whole genome shotgun
            sequence.
ACCESSION   NZ_JAMYDW010000017
VERSION     NZ_JAMYDW010000017.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 14568)
  AUTHORS   Xue,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUN-2022) Food Academy, Sichuan Agricultural
            University, Xinkang Road No. 48, Ya'an, Sichuan 625000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.0.2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024128815.1-RS_2024_09_24
            Annotation Date                   :: 09/24/2024 05:23:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,267
            CDSs (total)                      :: 4,141
            Genes (coding)                    :: 4,000
            CDSs (with protein)               :: 4,000
            Genes (RNA)                       :: 126
            rRNAs                             :: 12, 14, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 9 (5S)
            partial rRNAs                     :: 3, 14, 10 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 141
            CDSs (without protein)            :: 141
            Pseudo Genes (ambiguous residues) :: 0 of 141
            Pseudo Genes (frameshifted)       :: 75 of 141
            Pseudo Genes (incomplete)         :: 74 of 141
            Pseudo Genes (internal stop)      :: 17 of 141
            Pseudo Genes (multiple problems)  :: 21 of 141
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:26:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 14568
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAMYDW010000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..14568
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     gene            complement(<1..2997)
                     /locus_tag="NHM07_RS20725"
                     /old_locus_tag="NHM07_20725"
     CDS             complement(<1..2997)
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (2-30). E-value: 2.4e-16.
                     Score: 50.7. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20725_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (7-305). E-value:
                     1.7e-119. Score: 390.3. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20725_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (469-870). E-value: 3e-112.
                     Score: 367.2. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20725_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389714.1"
                     /locus_tag="NHM07_RS20725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NHM07_20725"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_253137490.1"
                     /sec_met_domain="Condensation (E-value: 5.3e-94, bitscore:
                     302.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.9e-124, bitscore:
                     401.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTINGQL
                     DLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCHIHVEDISHLNEKDKEHC
                     TEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDFLHI
                     YQALGKGQFPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKASPLPKRTDQMSD
                     GTLQQITFTIPEKETSELQKIAAACGATLNTVFQALWGIMLQKFNRRDDAVFGSVISGR
                     PSELKDVENMVGLFINTIPIRVQSDFLSFSDLVSGMQKDMTEAEAYSYFPLYDIQAQSA
                     LKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYRCSVKVIPGRTLYV
                     RIHFHTGTYQPNMMSEIKDYLQHMISDVISDPSLPVSKMTLLDEDKTRKIVSQNNRTVS
                     VSPEAPTLHGLFERQAAVTPERPAIRFSGGSLTYAELDMYASRLAAHLAARGVTNESIV
                     GILSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSVPNF
                     SGETLEVDMTSLASEKAENHLFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAVSFLTG
                     MQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIVKAITQE
                     KVTTAHFIPAMLNSFLDQAEMLALGDGTNLKRVFAGGEPLAPRTAARFASVLPQVSLIH
                     GYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGELYIA
                     GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIRG
                     YRIEPGEIEAALRSIEGVREAAVTVRTDSSEPELCAYVEGLQRNEVRAQLESLLPGYMV
                     PAYMIEMEQWPVTPSGKLDRNALPAPDGAADAETYTAPRNVTEMKLSQLWEDVLKNGPV
                     GIHDNFFDRG"
     source          1..14568
                     /collection_date="2021-12-11T16:00:00Z"
                     /db_xref="taxon:1423"
                     /geo_loc_name="China: Yaan"
                     /isolation_source="spice"
                     /mol_type="genomic DNA"
                     /organism="Bacillus subtilis"
                     /strain="X0416"
                     /submitter_seqid="contig17"
     cand_cluster    1..14568
                     /SMILES="NC(CCCN)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14568
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:>14564](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..>14564)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS_motif       complement(358..423)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0010"
                     /evalue="5.40E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="880"
                     /protein_start="858"
                     /score="40.7"
                     /tool="antismash"
                     /translation="FLGRTDDQVKIRGYRIEPGEIE"
     aSDomain        complement(388..1590)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20725_AMP-binding.1"
                     /evalue="3.00E-112"
                     /label="NHM07_RS20725_AMP-binding.1"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="870"
                     /protein_start="469"
                     /score="367.2"
                     /specificity="substrate consensus: Glu"
                     /tool="antismash"
                     /translation="FERQAAVTPERPAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE
                     SIVGILSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSV
                     PNFSGETLEVDMTSLASEKAENHLFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAVSF
                     LTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIVKAI
                     TQEKVTTAHFIPAMLNSFLDQAEMLALGDGTNLKRVFAGGEPLAPRTAARFASVLPQVS
                     LIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGEL
                     YIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVK
                     IR"
     aSModule        complement(388..2976)
                     /domains="nrpspksdomains_NHM07_RS20725_Condensation_DCL.1"
                     /domains="nrpspksdomains_NHM07_RS20725_AMP-binding.1"
                     /incomplete
                     /locus_tags="NHM07_RS20725"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(505..594)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0009"
                     /evalue="6.00E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="831"
                     /protein_start="801"
                     /score="56.9"
                     /tool="antismash"
                     /translation="PSGVAGELYIAGAGVARGYLNRPALTEERF"
     CDS_motif       complement(1120..1179)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0008"
                     /evalue="4.20E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="626"
                     /protein_start="606"
                     /score="34.5"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVAVEH"
     CDS_motif       complement(1363..1404)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0007"
                     /evalue="6.20E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="545"
                     /protein_start="531"
                     /score="19.3"
                     /tool="antismash"
                     /translation="LAVLKAGGAYLPLD"
     CDS_motif       complement(1930..2046)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0006"
                     /evalue="1.20E-18"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="356"
                     /protein_start="317"
                     /score="59.5"
                     /tool="antismash"
                     /translation="QKDMTEAEAYSYFPLYDIQAQSALKQELIDHIIVFENTP"
     aSDomain        complement(2083..2976)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20725_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.70E-119"
                     /label="NHM07_RS20725_Condensation_DCL.1"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="305"
                     /protein_start="7"
                     /score="390.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHILMDG"
                     /tool="antismash"
                     /translation="QDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTINGQLDLERFQK
                     SMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCHIHVEDISHLNEKDKEHCTEAFKEQ
                     DKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDFLHIYQALGKG
                     QFPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKASPLPKRTDQMSDGTLQQIT
                     FTIPEKETSELQKIAAACGATLNTVFQALWGIMLQKFNRRDDAVFGSVISGRPSELKDV
                     ENMVGLFINTIPIRVQS"
     CDS_motif       complement(2092..2187)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0005"
                     /evalue="9.30E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="302"
                     /protein_start="270"
                     /score="63.1"
                     /tool="antismash"
                     /translation="DAVFGSVISGRPSELKDVENMVGLFINTIPIR"
     CDS_motif       complement(2422..2460)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0004"
                     /evalue="5.50E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="192"
                     /protein_start="179"
                     /score="9.6"
                     /tool="antismash"
                     /translation="PYGTYIKWLMQQD"
     CDS_motif       complement(2506..2571)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0003"
                     /evalue="6.50E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="164"
                     /protein_start="142"
                     /score="34.6"
                     /tool="antismash"
                     /translation="HHHILMDGWCLGIVIKDFLHIY"
     CDS_motif       complement(2788..2904)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0002"
                     /evalue="1.80E-17"
                     /label="C2_DCL_024-062"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="70"
                     /protein_start="31"
                     /score="55.6"
                     /tool="antismash"
                     /translation="AYFEQASFTINGQLDLERFQKSMDAVFDRYDIFRTAFIY"
     aSDomain        complement(2908..2991)
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20725_NRPS-COM_Nterm.1"
                     /evalue="2.40E-16"
                     /label="NHM07_RS20725_NRPS-COM_Nterm.1"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="30"
                     /protein_start="2"
                     /score="50.7"
                     /tool="antismash"
                     /translation="QQPEIQDIYPLSFMQEGMLFHSLYDEQS"
     CDS_motif       complement(2926..2967)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20725_0001"
                     /evalue="6.00E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="NHM07_RS20725"
                     /protein_end="24"
                     /protein_start="10"
                     /score="15.0"
                     /tool="antismash"
                     /translation="YPLSFMQEGMLFHS"
     gene            complement(3014..10696)
                     /gene="ppsB"
                     /locus_tag="NHM07_RS20730"
                     /old_locus_tag="NHM07_20730"
     CDS             complement(3014..10696)
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (0-29). E-value: 1.6e-15.
                     Score: 48.0. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (7-309). E-value:
                     1.1e-110. Score: 361.4. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (474-865). E-value:
                     1.9e-110. Score: 361.2. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (970-1036). E-value: 1.8e-23. Score:
                     74.5. Matches aSDomain: nrpspksdomains_NHM07_RS20730_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1054-1341). E-value:
                     2e-103. Score: 337.5. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1505-1903). E-value:
                     3.6e-118. Score: 386.6. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2011-2078). E-value: 1.8e-20.
                     Score: 64.9. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (2088-2392). E-value:
                     2.9e-157. Score: 516.6. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (2403-2553). E-value: 9e-54.
                     Score: 173.5. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20730_TIGR01720.1"
                     /codon_start=1
                     /gene="ppsB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389715.1"
                     /locus_tag="NHM07_RS20730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NHM07_20730"
                     /product="plipastatin non-ribosomal peptide synthetase
                     PpsB"
                     /protein_id="WP_253137491.1"
                     /sec_met_domain="Condensation (E-value: 5.1e-96, bitscore:
                     308.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.1e-126, bitscore:
                     408.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-17, bitscore:
                     51.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGNL
                     CVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQEQQ
                     TLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILKEFF
                     SMYDSLKNNSPIQIGSTVPYSRYIKWLGEQDQEETAAYWSEYLKEYGNTASIPRIRRRT
                     ADGDYKAAQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDAVFGSV
                     ISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGYYPLYEI
                     QNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNYDFNIVIV
                     PGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPPEEQQVIQS
                     FNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIAHALIEKGVG
                     SGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQAAQLLIEEDL
                     ISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKGVLVDHHGIANT
                     LQWRREEYGMTEQDITLHLFSYVFDGCVTSLFTPLLSGACVLLTTDDEAKDVLALKRKI
                     ARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLELSQMICPSAELAN
                     EYGPTENSVATTILRHLNEKERITIGHPIRNTKVFVLHGNQMQPIGAAGELCISGAGLA
                     RGYYKQPELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIGRFDDQVKIRGYRIEL
                     REIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLPDLYQHLAGTLPSYMIP
                     ASIINIGRMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEADLAHIWEDVLNKQQIGI
                     RDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVESMAVKLMSLKEHAFTQIE
                     PADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRGNLNRQRLRSVLTELVNRHE
                     ALRTVFVLDRDEPVQIIYPEIAFDLKELEMESEQMLESAIETFIKPFDLSSGPLFRACV
                     ITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGKELPALNLHYKDFAVWQQEKHP
                     KELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFSGGTIELNIDKDTADELHRLMAE
                     TGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRPHADLERVIGMFVNTLAMRSKPEG
                     HKTFSSYLQDIRHLALTAYEHQDYPFEELADKLFTNREVNRNPLFDAMLVLQSSEDFRF
                     EVPGLSISSVTPKHDISKFDLTLHAEEHPSGIRCRFEYSTALFEEETITQWASYFIELV
                     KGVTADTEMRISDMQLLPAAERRLLLEKMGQYAAYPRNENIVSLFEKQAAKYPEHIAVV
                     CGHSQLTYRDLNEKAERAAAMLIKQGVRTGDIVGLMLDRSPDMIIGILSILKAGGAYLP
                     IDPEYPQERISFMLNDSGAKRLLTERGQNKPADYTGHILYIDECENDLFPADVNIQEIV
                     TDQPAYVIYTSGTTGQPKGVIVEHRNVISLLKHQNLPFEFNHEDIWTLFHSYCFDFSVW
                     EMFGALLNGGTLVVVSKETARDPHAFRLLLKKERVTVLNQTPTAFYGLMLEDQNHTDHL
                     NIRYVIFGGEALQPGMLQSWNKKYPHTDLINMYGITETTVHVTFKKLSAADIVKNKSNI
                     GRPLSTLQAYVMDAHMNLQPIGVPGELYIGGEGVARGYLNRDELTADRFVSNPYLPGDR
                     LYRTGDLAKRLSNGELEYLGRIDEQVKVRGHRIELGEIQAALLQYPMIKEAAVITRADE
                     QGQTAIYAYMVIKDQQAANISDIRTYLKNALPDFMLPARMIQIDSIPVTVNGKLDQKAL
                     PEPEKHAYTADDISPRNEIETVMAEIWEELLNVDELGVSANFFELGGDSIKALQVCARL
                     KQRGFETTVREMFEHQTLGELSARVRKDVRAIDQGPVEGEITWTPIQQWFFSLSLESHH
                     FNQSVMIYRAERFDEAALRKVLKSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYA
                     LELFDVKDSLTEARYTIEEAASRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVD
                     AVSWRILFEDFSAAYKQAVSGESIKLPQKTDSYLTYSQRIVDYSKSRQVQREAAYWDEC
                     ESRHIQPIPKDNDAASNTFKDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGL
                     ALQKWTGNDQFKISMEGHGRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLG
                     HLIKQTKDMLHRIPHKGAGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVS
                     DIKPGNEISPNWERPYALDISGAVSSGCLNMHLIYNRVQFEEKTIQTFSRHFKQTLENI
                     IEHCTGKENREWSASDFTDEDLTLDELSEIMGAVNKL"
     aSDomain        complement(3038..3487)
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_TIGR01720.1"
                     /evalue="9.00E-54"
                     /label="NHM07_RS20730_TIGR01720.1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2553"
                     /protein_start="2403"
                     /score="173.5"
                     /tool="antismash"
                     /translation="LGHLIKQTKDMLHRIPHKGAGYGVLKYISKRWGSQKNSPEISFNY
                     LGQFDQDIQSNAFEVSDIKPGNEISPNWERPYALDISGAVSSGCLNMHLIYNRVQFEEK
                     TIQTFSRHFKQTLENIIEHCTGKENREWSASDFTDEDLTLDELSEI"
     aSModule        complement(3038..7534)
                     /complete
                     /domains="nrpspksdomains_NHM07_RS20730_Condensation_LCL.1"
                     /domains="nrpspksdomains_NHM07_RS20730_AMP-binding.2"
                     /domains="nrpspksdomains_NHM07_RS20730_PCP.2"
                     /domains="nrpspksdomains_NHM07_RS20730_Epimerization.1"
                     /domains="nrpspksdomains_NHM07_RS20730_TIGR01720.1"
                     /locus_tags="NHM07_RS20730"
                     /monomer_pairings="Thr -> D-Thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(3407..3466)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0025"
                     /evalue="4.90E-08"
                     /label="NRPS-E6"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2430"
                     /protein_start="2410"
                     /score="25.3"
                     /tool="antismash"
                     /translation="TKDMLHRIPHKGAGYGVLKY"
     aSDomain        complement(3521..4432)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_Epimerization.1"
                     /evalue="2.90E-157"
                     /label="NHM07_RS20730_Epimerization.1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2392"
                     /protein_start="2088"
                     /score="516.6"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDA"
                     /tool="antismash"
                     /translation="EGEITWTPIQQWFFSLSLESHHFNQSVMIYRAERFDEAALRKVLK
                     SLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARYTIEEAASR
                     MQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSAAYKQAVSGES
                     IKLPQKTDSYLTYSQRIVDYSKSRQVQREAAYWDECESRHIQPIPKDNDAASNTFKDTE
                     VIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNDQFKISMEGHGRESY
                     LEDIDISRTVGWFTSIYPVWLDM"
     CDS_motif       complement(3527..3577)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0024"
                     /evalue="5.10E-09"
                     /label="NRPS-E5"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2390"
                     /protein_start="2373"
                     /score="28.0"
                     /tool="antismash"
                     /translation="DISRTVGWFTSIYPVWL"
     CDS_motif       complement(3980..4045)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0023"
                     /evalue="1.60E-11"
                     /label="NRPS-E2"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2239"
                     /protein_start="2217"
                     /score="36.3"
                     /tool="antismash"
                     /translation="LFLTIHHLVVDAVSWRILFEDF"
     CDS_motif       complement(4268..4333)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0022"
                     /evalue="1.60E-03"
                     /label="C2_LCL_024-062"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2143"
                     /protein_start="2121"
                     /score="10.9"
                     /tool="antismash"
                     /translation="RFDEAALRKVLKSLVTHHDALR"
     CDS_motif       complement(4391..4417)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0021"
                     /evalue="2.90E-03"
                     /label="NRPS-E1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2102"
                     /protein_start="2093"
                     /score="10.8"
                     /tool="antismash"
                     /translation="WTPIQQWFF"
     aSDomain        complement(4463..4663)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_PCP.2"
                     /evalue="1.80E-20"
                     /label="NHM07_RS20730_PCP.2"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="2078"
                     /protein_start="2011"
                     /score="64.9"
                     /tool="antismash"
                     /translation="ETVMAEIWEELLNVDELGVSANFFELGGDSIKALQVCARLKQRGF
                     ETTVREMFEHQTLGELSARVRK"
     CDS_motif       complement(4958..5023)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0020"
                     /evalue="3.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1913"
                     /protein_start="1891"
                     /score="35.3"
                     /tool="antismash"
                     /translation="YLGRIDEQVKVRGHRIELGEIQ"
     aSDomain        complement(4988..6181)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_AMP-binding.2"
                     /evalue="3.60E-118"
                     /label="NHM07_RS20730_AMP-binding.2"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1903"
                     /protein_start="1505"
                     /score="386.6"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="FEKQAAKYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTG
                     DIVGLMLDRSPDMIIGILSILKAGGAYLPIDPEYPQERISFMLNDSGAKRLLTERGQNK
                     PADYTGHILYIDECENDLFPADVNIQEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL
                     LKHQNLPFEFNHEDIWTLFHSYCFDFSVWEMFGALLNGGTLVVVSKETARDPHAFRLLL
                     KKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGMLQSWNKKYPHTDLI
                     NMYGITETTVHVTFKKLSAADIVKNKSNIGRPLSTLQAYVMDAHMNLQPIGVPGELYIG
                     GEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQVKVR"
     CDS_motif       complement(5105..5194)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0019"
                     /evalue="3.10E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1864"
                     /protein_start="1834"
                     /score="57.8"
                     /tool="antismash"
                     /translation="PIGVPGELYIGGEGVARGYLNRDELTADRF"
     CDS_motif       complement(5309..5332)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0018"
                     /evalue="2.50E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1796"
                     /protein_start="1788"
                     /score="2.0"
                     /tool="antismash"
                     /translation="YGITETTV"
     CDS_motif       complement(5711..5770)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0017"
                     /evalue="4.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1662"
                     /protein_start="1642"
                     /score="31.4"
                     /tool="antismash"
                     /translation="AYVIYTSGTTGQPKGVIVEH"
     CDS_motif       complement(5954..5995)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0016"
                     /evalue="1.70E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1581"
                     /protein_start="1567"
                     /score="15.0"
                     /tool="antismash"
                     /translation="LSILKAGGAYLPID"
     CDS_motif       complement(6515..6628)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0015"
                     /evalue="3.90E-13"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1394"
                     /protein_start="1356"
                     /score="41.7"
                     /tool="antismash"
                     /translation="LALTAYEHQDYPFEELADKLFTNREVNRNPLFDAMLVL"
     aSDomain        complement(6674..7534)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.00E-103"
                     /label="NHM07_RS20730_Condensation_LCL.1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1341"
                     /protein_start="1054"
                     /score="337.5"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIIADG"
                     /tool="antismash"
                     /translation="VYPLSFSQKRLYALHQLADDSTGYNMPAVLELRGNLNRQRLRSVL
                     TELVNRHEALRTVFVLDRDEPVQIIYPEIAFDLKELEMESEQMLESAIETFIKPFDLSS
                     GPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGKELPALNLHYKDFA
                     VWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFSGGTIELNIDKDTAD
                     ELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRPHADLERVIGMFVNTL
                     AMRSKP"
     CDS_motif       complement(6683..6772)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0014"
                     /evalue="8.90E-17"
                     /label="C5_LCL_267-296"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1338"
                     /protein_start="1308"
                     /score="53.4"
                     /tool="antismash"
                     /translation="DIVVGSPAAGRPHADLERVIGMFVNTLAMR"
     CDS_motif       complement(7031..7063)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0013"
                     /evalue="3.60E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1222"
                     /protein_start="1211"
                     /score="13.2"
                     /tool="antismash"
                     /translation="HYKDFAVWQQE"
     CDS_motif       complement(7094..7159)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0012"
                     /evalue="1.90E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1201"
                     /protein_start="1179"
                     /score="30.0"
                     /tool="antismash"
                     /translation="MHHIIADGVSMSTLVQEFTDLY"
     CDS_motif       complement(7355..7465)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0011"
                     /evalue="7.80E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1114"
                     /protein_start="1077"
                     /score="53.7"
                     /tool="antismash"
                     /translation="YNMPAVLELRGNLNRQRLRSVLTELVNRHEALRTVFV"
     aSDomain        complement(7589..7786)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_PCP.1"
                     /evalue="1.80E-23"
                     /label="NHM07_RS20730_PCP.1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="1036"
                     /protein_start="970"
                     /score="74.5"
                     /tool="antismash"
                     /translation="EADLAHIWEDVLNKQQIGIRDDFFQLGGQSLKAAALVSRIHKKLN
                     VELPLSEVFSYPTVESMAVKL"
     aSModule        complement(7589..10675)
                     /complete
                     /domains="nrpspksdomains_NHM07_RS20730_Condensation_DCL.1"
                     /domains="nrpspksdomains_NHM07_RS20730_AMP-binding.1"
                     /domains="nrpspksdomains_NHM07_RS20730_PCP.1"
                     /locus_tags="NHM07_RS20730"
                     /monomer_pairings="Tyr -> Tyr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(8072..8137)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0010"
                     /evalue="4.20E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="875"
                     /protein_start="853"
                     /score="34.8"
                     /tool="antismash"
                     /translation="YIGRFDDQVKIRGYRIELREIE"
     aSDomain        complement(8102..9274)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_AMP-binding.1"
                     /evalue="1.90E-110"
                     /label="NHM07_RS20730_AMP-binding.1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="865"
                     /protein_start="474"
                     /score="361.2"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="FEEQAHKTPEAAALKMGNECWTYRQLQVRANQIAHALIEKGVGSG
                     DIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQAAQLLIEEDLIS
                     LIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKGVLVDHHGIANTLQ
                     WRREEYGMTEQDITLHLFSYVFDGCVTSLFTPLLSGACVLLTTDDEAKDVLALKRKIAR
                     YKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLELSQMICPSAELANEY
                     GPTENSVATTILRHLNEKERITIGHPIRNTKVFVLHGNQMQPIGAAGELCISGAGLARG
                     YYKQPELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIGRFDDQVKIR"
     CDS_motif       complement(8219..8308)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0009"
                     /evalue="3.20E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="826"
                     /protein_start="796"
                     /score="48.2"
                     /tool="antismash"
                     /translation="PIGAAGELCISGAGLARGYYKQPELTQKAF"
     CDS_motif       complement(8405..8437)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0008"
                     /evalue="1.20E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="764"
                     /protein_start="753"
                     /score="5.7"
                     /tool="antismash"
                     /translation="EYGPTENSVAT"
     CDS_motif       complement(8810..8869)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0007"
                     /evalue="1.60E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="629"
                     /protein_start="609"
                     /score="29.8"
                     /tool="antismash"
                     /translation="AYLIYTSGTTGRPKGVLVDH"
     CDS_motif       complement(9047..9088)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0006"
                     /evalue="6.80E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="550"
                     /protein_start="536"
                     /score="16.1"
                     /tool="antismash"
                     /translation="LGIWKAGGAYMPLD"
     CDS_motif       complement(9614..9730)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0005"
                     /evalue="3.10E-19"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="361"
                     /protein_start="322"
                     /score="61.4"
                     /tool="antismash"
                     /translation="QEDILSSEQHGYYPLYEIQNHSPLKQGLIDHIFVFENYP"
     aSDomain        complement(9770..10675)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.10E-110"
                     /label="NHM07_RS20730_Condensation_DCL.1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="309"
                     /protein_start="7"
                     /score="361.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIIMDG"
                     /tool="antismash"
                     /translation="QDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGNLCVDSFQK
                     SLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQEQQTLIDAFM
                     TKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILKEFFSMYDSLK
                     NNSPIQIGSTVPYSRYIKWLGEQDQEETAAYWSEYLKEYGNTASIPRIRRRTADGDYKA
                     AQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDAVFGSVISGRPSA
                     IDGIESMVGLFINTVPVRIRS"
     CDS_motif       complement(9779..9874)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0004"
                     /evalue="2.40E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="306"
                     /protein_start="274"
                     /score="61.7"
                     /tool="antismash"
                     /translation="DAVFGSVISGRPSAIDGIESMVGLFINTVPVR"
     CDS_motif       complement(10199..10264)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0003"
                     /evalue="2.50E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="166"
                     /protein_start="144"
                     /score="35.9"
                     /tool="antismash"
                     /translation="HHHIIMDGWCLGIILKEFFSMY"
     CDS_motif       complement(10490..10603)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0002"
                     /evalue="2.10E-14"
                     /label="C2_DCL_024-062"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="69"
                     /protein_start="31"
                     /score="45.7"
                     /tool="antismash"
                     /translation="AYIEQTSFTITGNLCVDSFQKSLNLLVSRYDIFRTIFI"
     aSDomain        complement(10610..10696)
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20730_NRPS-COM_Nterm.1"
                     /evalue="1.60E-15"
                     /label="NHM07_RS20730_NRPS-COM_Nterm.1"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="29"
                     /protein_start="0"
                     /score="48.0"
                     /tool="antismash"
                     /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFS"
     CDS_motif       complement(10625..10666)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20730_0001"
                     /evalue="9.00E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="NHM07_RS20730"
                     /protein_end="24"
                     /protein_start="10"
                     /score="14.5"
                     /tool="antismash"
                     /translation="YPLSHMQEGMLFHS"
     CDS             complement(10721..>14564)
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (223-628). E-value: 8.3e-99.
                     Score: 322.9. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20735_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (733-797). E-value: 1.1e-21. Score:
                     68.8. Matches aSDomain: nrpspksdomains_NHM07_RS20735_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (809-1120). E-value:
                     6.2e-150. Score: 492.4. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20735_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1128-1273). E-value: 1.5e-46.
                     Score: 150.0. Matches aSDomain:
                     nrpspksdomains_NHM07_RS20735_TIGR01720.1"
                     /codon_start=3
                     /gene="ppsA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389716.2"
                     /locus_tag="NHM07_RS20735"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NHM07_20735"
                     /product="plipastatin non-ribosomal peptide synthetase
                     PpsA"
                     /pseudo=""
                     /sec_met_domain="AMP-binding (E-value: 2.2e-108, bitscore:
                     350.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6e-16, bitscore:
                     46.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.4e-88, bitscore:
                     284.4, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="NGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILG
                     MFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDMSRNPVF
                     DAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEFSTEVFLK
                     ATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFAQKDIPFHR
                     IFEAKAEEIPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAVLAKRSIDAI
                     VGVLAVMKAGGVYIPIDSHYPKARIEYILRDSGADILLSQQELKHLISNSPESEMSHIC
                     LDDESSYEESNCNLNLSPAPEEAVYIIYTSGTTGAPKGVIVTHQNFTHAALAWRQIYEL
                     DRKPVRLLQIASFSFDVFSGDLARTLSNGGTLIVCPDETRLEPAEIYKIMNSQRITVME
                     STPALIIPMMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFGQSMRIINSYGVTE
                     ATIDSSFYETSMSGECTGDNVPIGSPLPNVRMYVLSQTDQIQPIGVAGELCIGGAGVAK
                     GYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGRMDYQVKINGYRIETE
                     EIESVLLKTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNALRAALTKELPAYMIPAH
                     LIPLENMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDMQKTLAYIWEDVLSMSRVGIHD
                     SFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELCGHITPLASQADQGPAEGE
                     AELTPIQRRFFGQVHAFHYHYNQSVMLFSKKGFNANALHLALRKITEHHDAIRMIFQRD
                     QNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDEKLDAEETVIQSKMNVEKGPL
                     LQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAAYQQALEKKEIQLPPKTDSYLS
                     YADGLTQIAESKQLLSEKPYWQTILDAHTAFLPKDIENVPDRLQMNSDAAAFVLSGDWT
                     EKLLFETQQAYGTDANELLLTALGMALSEWTGHDQIVISTEGHGREGHVPNIDISRTVG
                     WFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRRVPNKGTGYGLLTHIGELRHKEPEV
                     SFNYLGQFSEEKEADTFELSYYKPRYEIAGEREREYELDINALITDGRLQVKAVYTQVF
                     SKHSIECFMDRFHRHLIETIEHCSQKKAREKTLSDFSNKELTLSALSSIEDLVKDL"
     gene            complement(10721..>14568)
                     /gene="ppsA"
                     /locus_tag="NHM07_RS20735"
                     /old_locus_tag="NHM07_20735"
                     /pseudo=""
     aSDomain        complement(10745..11179)
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20735_TIGR01720.1"
                     /evalue="1.50E-46"
                     /label="NHM07_RS20735_TIGR01720.1"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="1273"
                     /protein_start="1128"
                     /score="150.0"
                     /tool="antismash"
                     /translation="LAYRIKTTKDMLRRVPNKGTGYGLLTHIGELRHKEPEVSFNYLGQ
                     FSEEKEADTFELSYYKPRYEIAGEREREYELDINALITDGRLQVKAVYTQVFSKHSIEC
                     FMDRFHRHLIETIEHCSQKKAREKTLSDFSNKELTLSALSS"
     aSModule        complement(10745..13894)
                     /complete
                     /domains="nrpspksdomains_NHM07_RS20735_AMP-binding.1"
                     /domains="nrpspksdomains_NHM07_RS20735_PCP.1"
                     /domains="nrpspksdomains_NHM07_RS20735_Epimerization.1"
                     /domains="nrpspksdomains_NHM07_RS20735_TIGR01720.1"
                     /locus_tags="NHM07_RS20735"
                     /monomer_pairings="Orn -> D-Orn"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(11099..11158)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0014"
                     /evalue="9.50E-09"
                     /label="NRPS-E6"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="1155"
                     /protein_start="1135"
                     /score="27.5"
                     /tool="antismash"
                     /translation="TKDMLRRVPNKGTGYGLLTH"
     aSDomain        complement(11204..12136)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20735_Epimerization.1"
                     /evalue="6.20E-150"
                     /label="NHM07_RS20735_Epimerization.1"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="1120"
                     /protein_start="809"
                     /score="492.4"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVIDG"
                     /tool="antismash"
                     /translation="EGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSKKGFNANALHLAL
                     RKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDEKLD
                     AEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAAYQQA
                     LEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKPYWQTILDAHTAFLPKDIENVPDR
                     LQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQIVISTEG
                     HGREGHVPNIDISRTVGWFTSIYPILLDMG"
     CDS_motif       complement(11213..11263)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0013"
                     /evalue="4.60E-09"
                     /label="NRPS-E5"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="1117"
                     /protein_start="1100"
                     /score="28.2"
                     /tool="antismash"
                     /translation="DISRTVGWFTSIYPILL"
     CDS_motif       complement(11327..11368)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0012"
                     /evalue="2.40E+00"
                     /label="Cy4"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="1079"
                     /protein_start="1065"
                     /score="1.6"
                     /tool="antismash"
                     /translation="LLLTALGMALSEWT"
     CDS_motif       complement(11669..11734)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0011"
                     /evalue="2.60E-11"
                     /label="NRPS-E2"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="965"
                     /protein_start="943"
                     /score="35.7"
                     /tool="antismash"
                     /translation="LLIALHHLVIDGVSWRILLEDL"
     CDS_motif       complement(11960..12031)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0010"
                     /evalue="2.20E-02"
                     /label="C2_LCL_024-062"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="868"
                     /protein_start="844"
                     /score="7.2"
                     /tool="antismash"
                     /translation="FNANALHLALRKITEHHDAIRMIF"
     CDS_motif       complement(12095..12121)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0009"
                     /evalue="4.60E-03"
                     /label="NRPS-E1"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="823"
                     /protein_start="814"
                     /score="10.2"
                     /tool="antismash"
                     /translation="LTPIQRRFF"
     aSDomain        complement(12173..12364)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20735_PCP.1"
                     /evalue="1.10E-21"
                     /label="NHM07_RS20735_PCP.1"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="797"
                     /protein_start="733"
                     /score="68.8"
                     /tool="antismash"
                     /translation="KTLAYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWS
                     MTIRDLFRYSTIQELCGHI"
     CDS_motif       complement(12422..12553)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0008"
                     /evalue="1.30E+00"
                     /label="C2_LCL_024-062"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="714"
                     /protein_start="670"
                     /score="1.6"
                     /tool="antismash"
                     /translation="SDVNTNALRAALTKELPAYMIPAHLIPLENMPLTLNGKLDRNAL"
     CDS_motif       complement(12650..12712)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0007"
                     /evalue="2.50E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="638"
                     /protein_start="617"
                     /score="29.3"
                     /tool="antismash"
                     /translation="LGRMDYQVKINGYRIETEEIE"
     aSDomain        complement(12680..13894)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NHM07_RS20735_AMP-binding.1"
                     /evalue="8.30E-99"
                     /label="NHM07_RS20735_AMP-binding.1"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="628"
                     /protein_start="223"
                     /score="322.9"
                     /specificity="substrate consensus: Orn"
                     /tool="antismash"
                     /translation="FEAKAEEIPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKP
                     TVAVLAKRSIDAIVGVLAVMKAGGVYIPIDSHYPKARIEYILRDSGADILLSQQELKHL
                     ISNSPESEMSHICLDDESSYEESNCNLNLSPAPEEAVYIIYTSGTTGAPKGVIVTHQNF
                     THAALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLSNGGTLIVCPDETRLEPAEI
                     YKIMNSQRITVMESTPALIIPMMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG
                     QSMRIINSYGVTEATIDSSFYETSMSGECTGDNVPIGSPLPNVRMYVLSQTDQIQPIGV
                     AGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGRMD
                     YQVKIN"
     CDS_motif       complement(12797..12886)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0006"
                     /evalue="1.30E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="589"
                     /protein_start="559"
                     /score="46.3"
                     /tool="antismash"
                     /translation="PIGVAGELCIGGAGVAKGYHHKPDLTQMKF"
     CDS_motif       complement(13415..13471)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0005"
                     /evalue="7.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="383"
                     /protein_start="364"
                     /score="27.7"
                     /tool="antismash"
                     /translation="YIIYTSGTTGAPKGVIVTH"
     CDS_motif       complement(13670..13711)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0004"
                     /evalue="7.70E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="298"
                     /protein_start="284"
                     /score="16.0"
                     /tool="antismash"
                     /translation="LAVMKAGGVYIPID"
     CDS_motif       complement(14234..14353)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0003"
                     /evalue="6.00E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="110"
                     /protein_start="70"
                     /score="66.9"
                     /tool="antismash"
                     /translation="RETALEAFEHQDYPFEELVDKLELTRDMSRNPVFDAMFIL"
     CDS_motif       complement(14402..14491)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0002"
                     /evalue="1.40E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="54"
                     /protein_start="24"
                     /score="49.5"
                     /tool="antismash"
                     /translation="DIIVGSPIAGRPHKDLEPILGMFVNTLALR"
     CDS_motif       complement(14501..14554)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NHM07_RS20735_0001"
                     /evalue="3.50E-02"
                     /label="Cy4"
                     /locus_tag="NHM07_RS20735"
                     /protein_end="21"
                     /protein_start="3"
                     /score="7.3"
                     /tool="antismash"
                     /translation="TLYMVLLAAYTAFLSRLS"
ORIGIN
        1 cccgcggtca aaaaagttgt cgtgaatccc gacagggcca tttttcagca cgtcctccca
       61 cagctgagaa agcttcatct cagtcacgtt tctcggcgct gtgtaggtct ccgcatctgc
      121 cgctccgtca ggagctggca gggcgtttcg gtcgagcttt ccgcttggtg taaccggcca
      181 ctgttccatt tctatcatat aggctgggac catgtagccc ggcaacaggc tctcaagctg
      241 cgctcggact tcgtttcttt ggagcccttc tacataagcg cataattccg gctcgctgct
      301 gtctgtccgt acggtaacgg ccgcctccct tacgccttct atgcttctta gtgccgcttc
      361 aatctctccc ggctcaatcc ggtagccgcg aattttcacc tgatcatccg tacgcccgag
      421 gaattcaaca ttcccgtcag ggagccagcg cgcaacatcc cctgttttgt acatgcgttc
      481 ccccgggtaa aacgggtctt caagaaaacg ctcctccgtt aatgccggcc gattcaaata
      541 acctctggca acacccgctc cggcaatgta tagttcgccg gcgacaccgg aaggctgtac
      601 ggctaaatgc ggatctaaaa catacaaacg cgcaccaggt acgggcttcc caatcggaat
      661 ccgcaaacgg tctctgtccc gttctggatc caatacgtaa aatgccgcgt ctaccgttgc
      721 ttctgtcggc ccgtagccat ggattaatga tacctgcggc aatacagaag caaaacgggc
      781 tgccgtacgc ggcgcaagcg gttcacctcc ggcgaataca cgctttaggt ttgtcccgtc
      841 accaagcgct aacatttctg cttgatccag aaagctgttc agcatagccg gaataaaatg
      901 agccgttgtc actttttcct gagtaatggc ttttacgatc aatgcggagt ctttttccca
      961 gccgggcgga agcagatacg ccgaagcgcc ggaaagcgac caccaaaaca gctgccacac
     1021 agacgcatca aaggaaaaag aggttttcac catgacaatg tcatcttctg aaagcggaaa
     1081 ctggtgctgc atgccggtca gaaaggaaac agcctgacgg tgctcaacgg ccactccttt
     1141 cggctgcccg gtagagcccg atgtatagat gacataggcg agagaaccgc cgtcagcagg
     1201 agtaaacaga tggttttctg ctttttcgct cgcaagagat gtcatgtcca cttcaagcgt
     1261 ctctccggaa aagttcggta cggagcatcc cggctgcgtc agcaagagcg atgccccgct
     1321 gtctttcagc atgtagctca gccgctcctt tggatacgca ggatcaagcg gcaaatacgc
     1381 ccctccggcc ttcaatacag caaggacagc gatcagcatg tcaggtgagc gttcagacag
     1441 gatcccgacg atactttcgt ttgtgacgcc gcgtgccgca aggtgagcag ccagccggct
     1501 ggcgtacata tcaagctcag cgtatgtcag cgaaccgcct gaaaagcgaa tcgctggccg
     1561 ctccggtgtg actgccgcct gtcgttcaaa cagcccatgc aaggttgggg cttcaggtga
     1621 aacagatact gtcctgttat tttgagaaac gattttccgt gttttgtcct catctagcaa
     1681 tgtcatcttt gacacaggaa gagatggatc agagatgacg tcagagatca tgtgctgtaa
     1741 ataatctttt atctcagaca tcatatttgg ttgataagtg cctgtatgaa aatgaatccg
     1801 aacgtacaaa gtacgccctg ggatcacttt gacactgcat ctataattag ttacctcttc
     1861 catctcaaaa tctttcacgg agaaatcaaa tgatccagct tgattcagct cttcaatctc
     1921 ttgttgagta ggtgtatttt caaagacgat aatatgatca atcagctctt gtttaagagc
     1981 gctctgcgcc tgaatgtcat ataaagggaa gtaactatac gcttctgctt cagtcatgtc
     2041 cttttgcatt ccgctgacta ggtcagaaaa agacagaaaa tcactttgga ctcgaatagg
     2101 aatggtattg ataaaaagtc cgaccatgtt ttccacatct tttagctcag aaggtctgcc
     2161 tgatataact gatccgaata cagcatcgtc gcgacgattg aacttttgga gcatgattcc
     2221 ccataaagct tggaaaacag tgttaagtgt cgcaccacat gctgcagcga ttttctgtaa
     2281 ttcggaggtt tctttttcag gaatggtaaa cgtgatctgc tgtaatgtcc catccgacat
     2341 ttgatctgtt cttttaggca gaggtgaagc tttttcgaaa tgctgaagcc tctttttcca
     2401 atactcagct gcttcttccc ggtcttgctg catcagccat ttaatatacg tcccgtacgg
     2461 ctgtacggga ggcaaatcag gaaactgccc ttttccaagc gcttgataaa tatggagaaa
     2521 gtctttaatg acgatgccta aacaccagcc atccattaaa atatgatggt ggctccagat
     2581 acagacataa tgatcaggcg cccattttaa aatagatatt ctcatcagta catccgtttg
     2641 gagatcaaag ccttttgatt tatcctgttc tttgaatgcc tctgtacaat gttctttatc
     2701 tttttcattg agatgagaaa tatcttcaac atgaatatgg caatgacgtt gcttgagcac
     2761 gacttgacga ggtttggcta catttttata gatgaatgct gttcgaaaga tatcgtacct
     2821 gtcaaaaaca gcatccatac ttttctggaa acgctccaag tcgagctgtc cattgatcgt
     2881 aaaagaagcc tgttcaaaat aagctctcga ctgttcatca tacaatgagt gaaaaagcat
     2941 cccttcctgc ataaatgaca aagggtatat atcctgtatt tcaggttgct gcggcatcag
     3001 tgaatctcct ctcctatagt ttgttgacgg ctcccatgat ctcactcaat tcatcaagcg
     3061 ttaagtcttc atcagtgaaa tcagatgcgc tccactctcg gttttctttg ccggtacaat
     3121 gctcaatgat gttttccaga gtctgtttaa aatgcctgga aaatgtttgg attgtttttt
     3181 cctcaaattg aaccctgtta tagatgaggt gcatgttcag gcaccccgaa gaaacggcgc
     3241 cgctgatatc cagtgcataa ggacgctccc agttcgggct gatctcattt cctggcttga
     3301 tgtcagacac ctcaaaggca tttgattgaa tatcctgatc aaactggcct aaataattaa
     3361 agctgatttc tggactgttt ttctgagagc cccatctttt gctgatatat ttcagcacgc
     3421 cgtagcccgc gcctttatgc ggtatacggt gcagcatatc ttttgtctgt ttaataaggt
     3481 ggcccagccg ctcttctttg tccttatgat cggaatctct catatcaagc cacacaggat
     3541 aaatagaggt gaaccagcca acagttctgc taatatcgat gtcctcaaga tatgattccc
     3601 ttccgtggcc ctccatgctg attttaaatt ggtcatttcc cgtccatttc tgcaaagcaa
     3661 gacctaaagc tgtcagaagg atatcattca tctccgtgct gtaagcttta tgtgcagccg
     3721 ttagtagtaa ttctgtgtga tggcgagata gctcaaaatc aatcacttct gtatctttga
     3781 atgtgttaga tgctgcgtca ttgtcttttg gaataggctg gatgtgacgg ctctcgcact
     3841 catcccagta cgctgcttcg cgctgcacct ggcggctttt agagtagtca actattcttt
     3901 gtgaatacgt taaatatgaa tctgtttttt gcggcagttt aatagattct cctgagactg
     3961 cctgtttgta agcagctgaa aaatcctcga acaaaatgcg ccaggaaacc gcatcaacaa
     4021 ctaagtgatg aatcgtcaga aataaatggt caccattctc ggttctaaac aatccagcgt
     4081 gaagtaaggg gccggtttcc aaacgaatat gttcttgcat ccggctggct gcttcctcaa
     4141 tcgtgtaccg tgcttctgtt aggctatcct ttacatcaaa cagttcaagt gcatatagct
     4201 cctcatctga aagatctatc cctctgttta tctgcacctg cctgccatct tcatgccggc
     4261 atacgattct cagtgcatca tgatgagtca caaggctttt tagtactttt ctaagcgcag
     4321 cctcatcaaa tcgttcagcc cggtagatca taacggactg gttaaaatga tggctttcca
     4381 gagatagcga gaaaaaccac tgctggatag gtgtccaagt aatctcgcct tcgaccgggc
     4441 cttggtcaat ggcgcgtacg tcttttcgaa cccgggcgga cagttcacca agagtctgat
     4501 gttcaaacat ctcacgtact gtcgtttcaa atccgcgctg cttcagtctg gcacaaacct
     4561 gcagcgcttt aatagagtct ccgccaagct caaagaaatt ggcgcttaca cccagctcat
     4621 ctacattaag aagctcctcc caaatttcag ccatcaccgt ttcaatctca tttctaggac
     4681 tgatatcatc agctgtataa gcgtgttttt caggctctgg cagggctttc tgatcgagct
     4741 ttccattaac agtcaccggg atgctgtcaa tttgtatcat acgggcaggc agcataaagt
     4801 caggcaaggc gttttttagg taagttcgga tgtctgatat attcgcagcc tgttgatctt
     4861 ttatcaccat atatgcatat atagctgttt gcccttgctc gtctgctctg gtaatgacag
     4921 ccgcctcttt aatcattgga tactgaagaa gtgccgcttg gatttcgcct aactcaatac
     4981 ggtgccctct gactttcacc tgctcatcaa tgcggcctaa gtattccagc tcgccatttg
     5041 acaggcgctt agcaagatct cctgttcggt ataatctgtc tcccggaaga taaggattgg
     5101 atacaaaacg gtcagcggtc agctcatctc tgttgagata tccccgtgcc acaccttcgc
     5161 cgcctatata cagctcccct ggaactccga tcggctgcag attcatatga gcatccatca
     5221 cataagcctg cagagttgaa agcggccgtc cgatattgct tttatttttt acaatgtctg
     5281 ctgcggacaa ttttttgaat gttacatgga ccgttgtttc tgtaataccg tacatattaa
     5341 tcaaatcagt atgaggatat tttttattcc agctttgaag catgccgggc tgtaaggctt
     5401 cgccgccaaa aatcacgtag cggatgttta aatgatctgt atgattttga tcttcaagca
     5461 tcaagccgta aaaagcagtc ggggtctgat tgagtacagt gacgcgctct ttttttaata
     5521 ataaacggaa tgcatggggg tcacgggctg tttctttaga gaccacgact aatgtacctc
     5581 cgttcaataa cgcaccgaac atctcccata cagagaaatc aaagcaataa gaatgaaata
     5641 acgtccagat gtcttcatgg ttaaattcaa aaggcaggtt ttgatgcttc aagagactga
     5701 tcacattgcg gtgctcgaca atgactccct ttggctggcc agtcgttccg gatgtgtata
     5761 tcacgtatgc gggctgatct gttactattt cttgaatgtt tacatcagcc ggaaataagt
     5821 cgttttcaca ttcatcgata tacaaaatat gcccggtgta gtctgcaggt ttgttttgac
     5881 cgcgctctgt cagcagccgt tttgctccgc tgtcattgag cataaagcta atacgctcct
     5941 gaggatattc aggatcaatc ggcaagtagg ccccgccagc ttttaaaatc gataaaatgc
     6001 caatgatcat atcaggtgac cgatcgagca tcagaccgac gatatcgcca gttctgaccc
     6061 cttgtttgat cagcatagca gctgcccgct cggctttttc attcaggtct cgatacgtaa
     6121 gctgagaatg gccgcacacc actgcgatat gctccggata tttagcggct tgcttttcaa
     6181 ataagcttac tatgttttca tttctcggat aagccgcata ctgtcccatt ttttcaagga
     6241 gcaacctacg ctctgcagca ggaagcaatt gcatgtccga aattctcatc tcggtatccg
     6301 ccgttacccc tttcaccaat tcaataaaat aggatgccca ctgcgtaatg gtttcttctt
     6361 caaaaagagc agtgctgtat tcaaaacggc agcgtattcc actcggatgc tcctcagcgt
     6421 gtaatgttaa atcgaattta gatatatcat gtttaggagt gacagacgaa atcgacagac
     6481 caggcacttc gaaccggaaa tcttcactgc tttgaagcac aagcatcgca tcgaacagcg
     6541 ggttgcgatt tacctctcga tttgtaaaga gcttatctgc cagctcctca aaaggataat
     6601 cctgatgctc gtaagctgtc agagccaggt ggcgaatgtc ctgcaaatag gagctgaacg
     6661 ttttgtggcc ctcgggcttg ctgcgcatcg ccaatgtatt gacgaacatc ccgatgacgc
     6721 gctccagatc agcgtgcggt cttccggcag caggcgaacc gacaacaata tcctcttgcc
     6781 cgcttagctt agataacaaa atagaataga cagccagaag aatcatatac aatgttgttc
     6841 ccgtttcagc cattaaacgg tgcagctcat cagccgtgtc tttatcaatg ttgagttcaa
     6901 ttgttccacc gctgaaatca gggagacgcg gccttgtttt atcaagcggt aattctagtg
     6961 taggaagact cccgccaagc tgaccgagcc agtaggcctc ctgttttttg tatagctctt
     7021 tcgggtgctt ctcttgctgc caaacagcaa aatccttata atgcaggttt aaagctggca
     7081 actcttttcc gcaatataag tcagtaaatt cttggacaag agtgctcatc gagacaccgt
     7141 cggcaataat atggtgcata tcgagcagca aaaagccgcg attattgccc attgtaatga
     7201 cacatgctct aaaaagcgga ccggatgata gatcaaacgg tttgataaag gtctcgattg
     7261 cagactcaag catttgttct gattccattt caagctcttt tagatcaaaa gctatctctg
     7321 gataaatgat ctgcacaggc tcgtctctgt caagcacaaa aacagtccgt aatgcttcat
     7381 gccgattcac aagttctgtg agaacgcttc tcaaccgctg gcgattcaga tttccgcgta
     7441 attcaagtac agctggcatg ttgtagcctg tgctgtcatc tgccagctga tgaagagcat
     7501 ataatcgttt ttgcgagaaa gacagcggat agacatctct ttgatccgca ggttcaatct
     7561 gtgtaaaagc gtgttctttt aagctcatca atttgaccgc catgctttca accgtcggat
     7621 atgaaaacac ctcactgagc ggcagctcga cattaagctt tttatgtatt cttgatacca
     7681 gtgcggccgc ttttaaggac tgtccgccta actgaaagaa atcatcacga atgccgattt
     7741 gctgtttatt cagcacatct tcccaaatat gtgcgagatc agcttcgatt aaggttcggg
     7801 gcgccatata tgtgacactc gtattgtttt ctggttcagg aagcgcaaac ctgtcaagct
     7861 tgccgctgga tgttaatggc atccggccga tgttgataat acttgctggg atcatatagg
     7921 acggcaatgt cccggcaaga tgctgataca aatctgggag gctgtttccc ttttctggaa
     7981 cgatataagc aacaagctcc ttttcctcag cagaaacatc acgggccagt accgcggctt
     8041 cttttacccc gggtgcttgt cgaagaactg tttcaatctc tctcagttca atacggtaac
     8101 ccctaatttt tacttgatca tcaaaacgtc caatatattc aatcgttcca tcaggcaaaa
     8161 agcggcctgc atcacctgtt cggtataaac gctccccttc aaggaatgga tgatcggaga
     8221 atgctttctg tgtcagctct ggctgtttgt agtatcctct cgcaagaccc gcgccggaaa
     8281 tacacagttc acccgccgcg ccgatcggct gcatttgatt tccgtgcaaa acaaatactt
     8341 ttgtgtttct gatcgggtgt ccgatcgtga tcctctcttt ttcattcaga tgccgcaata
     8401 ttgttgttgc cacactgttt tctgtgggcc cgtattcatt tgccagttct gcagaaggac
     8461 aaatcatttg actcaactca agcagatcag gcgtgaccgc ttcacccgca aatgtcacaa
     8521 tacgaagact ttttgcatcg tcagcagtca tcacttccaa taacaccctg tacagggaag
     8581 gaacaatgat catgtggctg accttataac gggctatttt tcgcttaagg gccagcacat
     8641 ccttcgcttc gtcatctgtt gtcagcagta cgcacgcacc agataaaagc ggggtaaata
     8701 agctcgttac acagccgtca aacacgtacg aaaacaaatg gagggttata tcctgttcgg
     8761 tcatgccata ctcttcccgt ctccattgca atgtattggc aataccgtga tgatctacta
     8821 aaaccccttt agggcgcccc gtcgttcccg acgtatatat caagtaggct agatcacctg
     8881 gcggcatatt tggcgcttct gtttggtaac tttctgtatg ttctatcgtt atcgtatttc
     8941 cttcatagga cggagggatc aaagaaataa ggtcttcttc tatcagcaat tgagccgctt
     9001 gactgtcctt cagcaggaaa gaaagacgtt ctgctggaaa atgtggatca agcggcatat
     9061 aagcgccgcc tgctttccaa atcccaagca gagctgcagg catttccatt gaccggccca
     9121 tcattacagc aacgatatct ccagatccaa cgcctttttc tatcagagcg tgcgcaatct
     9181 gattggctct tacttgtaac tggcgatagg tccagcattc gtttcccatt ttcaatgcag
     9241 cagcttcagg tgttttgtga gcttgttcct cgaacaattg aggtattgtt ttgttcacat
     9301 aaggacgctc agtttcgtta aacgattgga taacctgttg ctcctccggc ggcacgatat
     9361 tgatgtcact gacggcaaca tcgggatttg tcaaaatgca atccagtgct tgctttagat
     9421 gcccctgaat tctcagcatc tcctcccgct cgtaaacgtc tgcgttgtag ctgaatttga
     9481 tataaaatga ttctcccgga acgataacga tattaaagtc gtaattggtt tgttccgaca
     9541 ttgaaatgtc actcagcttc agagcgcctt cgtcattttc actctccacg cttaatgcct
     9601 gatgaagctg tacagggtaa ttttcaaaaa caaaaatatg atcgatcaac ccttgcttca
     9661 atggactatg gttttgaatc tcataaagcg gataatagcc atgctgttca gatgataaaa
     9721 tatcctcctg tacggctttg accagcgaag aaaacgttat gccttccgca gatcggattc
     9781 gcactggaac agtattgata aacaagccga ccattgattc aatcccgtca atcgctgacg
     9841 ggcgtcccga aatgacggag ccaaaaacgg catcatctgc agcattatat cgatggagca
     9901 gcacgcccca aatactcata aacagcgtgt ttaatgtcac tccccagttt tgggcagcct
     9961 ctgtcagttt ctcaaccata tccggcgcta atgaaaagct gacctgggcg gctttataat
    10021 ccccgtctgc cgtgcggcgc cttattcggg gaatagaagc agtattgccg tactccttca
    10081 aatattcgct ccagtaggca gcagtctctt cttgatcttg ttctccgagc catttaatat
    10141 aacggctgta cggcaccgtg ctgccaatct gtataggtga gttatttttg agcgaatcat
    10201 acatgctgaa aaactcttta agaataatgc cgagacacca cccatccatg atgatatggt
    10261 gatgtgtcca gacacatgta tattggctgt ctcctctatc aaaaagggca agacgcatta
    10321 aaggatcttt ttgcaaatca aatccttttt cccgatcctt agtcataaaa gcatcaatca
    10381 gcgtctgctg ttcttgatca gccaggcgag aaatatcttc tctatatact gtcaattccc
    10441 ggtttgataa gactacctgc tgcggacctg taagatctgg tacttcttta atgaaaatcg
    10501 ttctgaaaat atcatatcta gaaacaagaa ggtttaagct cttttgaaac gagtcgacgc
    10561 atagattccc tgtgatcgta aacgaggtct gttcgatata tgctttcgag ctgaaatcca
    10621 ttaatgaatg aaacagcatt ccttcctgca tgtgcgataa cggataaata tcttgaattt
    10681 gtgccgattg tgccatcaat tccacacacc ttttcaaaag ttaaagatct ttcacgagat
    10741 cttcgatgct agataatgca gacaacgtta attccttatt gctgaaatcg ctcaatgttt
    10801 tttcgcgtgc ttttttctgc gaacaatgct caatcgtctc gataagatgc ctgtgaaaac
    10861 gatccataaa gcactcaatt gagtgtttgc tgaacacctg ggtgtatacc gcttttactt
    10921 gaagccgtcc gtccgtaatg agagcgttga tgtccagctc atactctcgt tctctctcac
    10981 ccgctatttc gtaacggggc ttgtaatatg ataattcaaa cgtatcagct tccttctctt
    11041 cgctaaattg gccgagataa ttaaagctga cctcaggctc tttatgccgc agttctccta
    11101 tgtgtgttaa caatccgtat ccagttcctt tgttcggtac tcttctcagc atatcttttg
    11161 tcgtcttaat tcggtatgcg agctgatcct cgaaaggctc gggaataccc atgtctagca
    11221 gaataggata aatggaagta aaccatccaa ctgtccttga aatatcaatg tttggcacat
    11281 gcccttctct gccgtgtccc tcagtgctga tcacgatttg gtcatgccca gtccattcag
    11341 aaagcgccat tcctaaagcc gtaagcaaaa gttcgttggc atcagtacca taggcttgct
    11401 gggtttcaaa cagcaatttt tcagtccagt ccccggatag tacaaacgca gctgcgtcgc
    11461 tgttcatttg gagtctgtcc ggcacatttt ctatgtcctt aggaagaaaa gcagtgtgag
    11521 cgtctaaaat cgtttgccaa tacggtttct ctgaaagcaa ttgtttactt tcagctattt
    11581 gggtaagacc atcggcgtag gataaataag aatccgtttt tggcggtaat tggatttctt
    11641 tcttttctaa agcctgttga tatgctgcag ctaaatcctc aagcagaatt ctccaagaaa
    11701 cgccatctat cacaagatga tgaagtgcaa tcagcaaatg atccccttct gccgttttaa
    11761 acaaacctgc ttgcagcaaa ggaccttttt ctacattcat tttgctttga atgacggttt
    11821 cctcagcgtc aagtttttca tcaagatgag ccctttccag cgatgctttt gtccaatctg
    11881 aaatataaag gccaaacagt tcatgatcct tgtgattgat tccacgatta aactgaatga
    11941 catggccgtt ttggtcacgt tggaaaatca tgcgaatggc atcatgatgc tcggttattt
    12001 tacgcagcgc tagatgaagc gcgttagcat tgaatccttt tttactgaaa agcatgacgg
    12061 actggttgta atgatagtga aaagcatgta cctgtccgaa aaatcttcgc tgaatcgggg
    12121 tgagttcagc ttcaccttcc gcaggtccct ggtccgcttg agatgccaat ggtgtgatat
    12181 gtccgcatag ttcctgaatc gttgaataac ggaataagtc gcgtattgtc atgctccagc
    12241 cttcagctgc cagacgtgct gctacttgta atgctttaat tgagtctccg ccaagctcaa
    12301 aaaaggaatc gtgaatgccg actcgtgaca tgctcagtac atcttcccat atatacgcca
    12361 acgttttttg catgtcgtta actggtgcgg tatatggacg cgataacaca ttatttggag
    12421 ccggcaaggc atttctgtcc agctttccgt ttagggttag cggcatgttt tctaaaggaa
    12481 tcagatgtgc aggaatcata tacgctggca gctcctttgt taaagcagca cggagagcat
    12541 tcgtattgac gtctgaaggc acaatatatg ctgccaaacc agcctgtcca ttcttatcat
    12601 gctgaacggc aacagcagct tctctgacaa gccccgtttt aagcagaaca ctttcaattt
    12661 cttctgtttc aattctgtat ccatttatct tcacttgata atccattcgg ccaagaagcc
    12721 ggatcgttcc gtttggaagc cagcatgctc gatcaccggt tctgtacagc ctttctccag
    12781 agacaaatgg attttctgta aatttcattt gcgttaagtc aggtttatga tgatagcctt
    12841 tcgcaacacc tgccccgccg atgcacagct cgccggcaac gccgatcggc tgaatttgat
    12901 cagtctggct gagtacgtac atgcgtacat tcggcagcgg gctgccgatt ggtacgttat
    12961 cgcccgtaca ctctccactc atacttgttt cataaaagct cgaatcaatg gttgcctctg
    13021 tgacaccata gctattgatg atgcgcatgc tttgaccaaa gcggtctgtc aatgttttga
    13081 aatcttgagc tttcaccatg tcggaaccaa gaatcagtat gtctaagtca gggagcttga
    13141 actggttacg gtatacatac tccatcatcg ggataatgag agccggtgtc gactccatca
    13201 ccgtaattct ctgagagttc atgatcttat atatttcagc aggttccagc cgtgtttcat
    13261 ctgggcaaac gattagagtc ccgccgttgg acaatgttct cgccaaatct cctgagaaga
    13321 catcgaatga aaagctcgcg atttgaagca gtctgacagg cttccgatcc agttcataaa
    13381 tttgacgcca agcaagagca gcatgagtaa agttctgatg ggtgacaata acacctttag
    13441 gcgcacccgt cgttcctgac gtataaatga tatataccgc ctcttcagga gcaggagata
    13501 agttaaggtt gcaattactt tcttcataag agctttcatc gtcaaggcag atatgagaca
    13561 tctcagattc aggcgagttc gaaatcaaat gcttcaattc ctgctgtgaa agtagaatat
    13621 ctgctccgct atcacgaaga atatattcaa tacgggcttt tggataatgt gaatcgattg
    13681 ggatatacac tccgccagct ttcatcactg ccagcactcc aacaattgca tcaatggacc
    13741 gcttggctaa aacagccaca gttggcttcg gtccttttct gttttgcaat gttcgtgcca
    13801 gacgattggc tctttcattt agaaggcgat agctaatctc tgtttcgtta tcaataacag
    13861 ctatatgttc tggaatttct tcagctttcg cttcaaatat gcgatgaaaa ggaatatctt
    13921 tttgagcaaa ttcaacttga gttttgttaa attcaaagac tattttttgt ttttctttat
    13981 cactaagtat gtttatttgt gcaaggcttg tttcaggagt tgaaagtgcc tcatgcagaa
    14041 attcgataaa atgatcagcc cagcgttcaa tcgtagcttt caggaatact tctgtactaa
    14101 attccatttc gcagcaaata gatccactta tttccgtagc tattaatgtg atatcaaata
    14161 aggaaatgtg atgtgcgaaa ttggcaggcc ggacttttat ttctctcaga tctatgtctt
    14221 gtttttccac attttgaagg ataaacatcg catcaaacac tgggttccgg ctcatgtccc
    14281 gtgtcaattc aagcttatcg acaagctctt cgaacgggta atcttggtgc tcaaaggctt
    14341 ccaatgctgt ctcacgcact tcctgcaaat actgtacgaa tggcttcccg ccctccgggc
    14401 gtgtccgaag cgccagcgtg ttcacaaaca tgccgagtat cggctcaaga tccttgtgcg
    14461 gccggccggc aattggcgag ccgacgatga tatcttcctg tccgcttaag cgtgacaaga
    14521 acgcggtgta agccgcaagg agcaccatgt acagtgtgct tccgtttt
//
