LOCUS       NZ_CP099738            33738 bp    DNA     circular CON 27-AUG-2024
DEFINITION  Lentzea sp. HUAS12 chromosome.
ACCESSION   NZ_CP099738
VERSION     NZ_CP099738.1
KEYWORDS    RefSeq.
SOURCE      Lentzea sp. HUAS12
  ORGANISM  Lentzea sp. HUAS12
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 9676923)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024125735.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 06:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,161
            CDSs (total)                      :: 9,080
            Genes (coding)                    :: 8,988
            CDSs (with protein)               :: 8,988
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 21 of 92
            Pseudo Genes (incomplete)         :: 77 of 92
            Pseudo Genes (internal stop)      :: 3 of 92
            Pseudo Genes (multiple problems)  :: 8 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:47:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8117040
            Orig. end                         :: 8150778
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099738.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ping Mo.
FEATURES             Location/Qualifiers
     region          1..33738
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NAPAA"
                     /region_number="31"
                     /rules="(AMP-binding and TIGR02353)"
                     /tool="antismash"
     cand_cluster    1..33738
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(AMP-binding and TIGR02353)"
                     /kind="single"
                     /product="NAPAA"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..33738
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[15000:18738](-)"
                     /cutoff="5000"
                     /detection_rule="(AMP-binding and TIGR02353)"
                     /neighbourhood="15000"
                     /product="NAPAA"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(15001..18738)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(AMP-binding and TIGR02353)"
                     /neighbourhood="15000"
                     /product="NAPAA"
                     /protocluster_number="1"
     misc_feature    181..195
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.85"
                     /tool="antismash"
     misc_feature    complement(882..896)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.36"
                     /tool="antismash"
     misc_feature    complement(950..969)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.49"
                     /tool="antismash"
     misc_feature    1526..1541
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
     gene            1566..2009
                     /locus_tag="ND450_RS38090"
                     /old_locus_tag="ND450_38090"
     CDS             1566..2009
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102480.1"
                     /locus_tag="ND450_RS38090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38090"
                     /product="DUF6098 family protein"
                     /protein_id="WP_253322960.1"
                     /transl_table=11
                     /translation="MTARMPTITSLADLVGLIDDDIYVRWSKGPDADAASTSRDSLTGV
                     ELPGLSASPPRIEPWWDDRSHELWVARRLFDYRHLRDLRGPDVRAWVLRGEEVGRGPDN
                     EPLVRCREPLAWVDDEALRECVELVGAQHSDEWGPLDRSSSGR"
     gene            complement(1993..2679)
                     /locus_tag="ND450_RS38095"
                     /old_locus_tag="ND450_38095"
     CDS             complement(1993..2679)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS38095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_38095"
                     /product="hypothetical protein"
                     /protein_id="WP_253322961.1"
                     /transl_table=11
                     /translation="MDLKPVADELYGLPPKDFTAARNAAAKQAGDKDLAKAIADLRKPT
                     VGAWAVNKLVRDAPEGLEEALGLSTAKLTMRELGRRRKELVEALVYRTLELTGPLADDA
                     VTQVRNTLTAAMADPESAEQVRDGHLTKALEYSGFGFALPEPEPAQDGEDALARKRRER
                     EERKRAEAQQALDEAEQALGEAQADQLAAQRAFDRAAERLEDAKRVTSGAEKARKAAER
                     KLNDLS"
     gene            complement(2707..4083)
                     /locus_tag="ND450_RS38100"
                     /old_locus_tag="ND450_38100"
     CDS             complement(2707..4083)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS38100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_38100"
                     /product="hypothetical protein"
                     /protein_id="WP_253322962.1"
                     /transl_table=11
                     /translation="MITGQRGVGKTQLAAAYARQRVSDGWLVAWIGAENKEGIEAGMVE
                     LGDRLSLYRPEDGSKLTAARVRNHLRTRPGRSLLVFDNAVSLDAVREYLPVAGETQMVI
                     TSTARGSQLEHRGVLVEAFDEEISLRFLRAATGIAHDAGAAELAREVGGLPLALAQAAA
                     RIRTSGWDYQTYLARFRQFPAENHLRRRDGDDHPLSAAKAVLIALEPFEDSAVLETLAL
                     LAPEGVSRELLGEETDDHLALLYESSLIEYADRSSVRTHRLVQKIIRDCRQAAGTYDAA
                     LERVAGVLEASLDKAPSLREYRLDFNEILAGHSAALVRNTIGRSDSRATAAVTRAVVSI
                     HLWLTRRALQEELNLTEIVVTIRSEMSAGEVADAFERVFRRMRDALGATDPDTIKAAIA
                     LGRANDAAGRYQDVIAVLQEVHMAPGFGWNGGEASGEALRLYTHAERMLGAGHHDVRQD
                     "
     misc_feature    4163..4178
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.78"
                     /tool="antismash"
     gene            4298..4840
                     /locus_tag="ND450_RS38105"
                     /old_locus_tag="ND450_38105"
     CDS             4298..4840
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS38105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_38105"
                     /product="hypothetical protein"
                     /protein_id="WP_253322963.1"
                     /transl_table=11
                     /translation="MHTRWRWVLFGLGIAVAAVGPLAAKDGPWYAYLFGGLWFLMGATV
                     AWRTFNLGTKLTAEGLTSHGLDHQTTVEWCDVQGFEPKRSRNLVLFHTITPAAQLRRGT
                     HVLTELSLLSIKKDVVPRRTAQQVTELEQALAKHRKTCSVCGTQPKALAPPQGIVGRLR
                     ARLRELMGGNGDRSIVR"
     misc_feature    complement(4323..4338)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    4793..4795
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5091..8327
                     /locus_tag="ND450_RS38110"
                     /old_locus_tag="ND450_38110"
     CDS             5091..8327
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156426.1"
                     /locus_tag="ND450_RS38110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38110"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_253322964.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.3e-52, bitscore:
                     176.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNWRRRTGTVLLTAVLGTTGFGFAATPAIAQNASQQQQPAADKQ
                     LDKQDRALVEKAAQEGKPTVDLLVAAEDGKTDAAVNDLKALGATVQKTEKDVDYVKVTI
                     PRENAEKAAKLASVSTVDVDGLVALDNPRPEGMENPAPQKAPDAKTPRTNPYMPTQDTQ
                     AAQFATAHSKWDGRGTTIAVIDSGIDLDTPALQTTSTGERKIIDWYNANATNSGDGTWV
                     TMTKTGRTGTFVEGGKTYKAPATGGPYSFGLFSETAGDLNLSNSETGGDINRDGDRTDS
                     FGVIQDITTKEVFVDTDGDGDFTNNKRMIDYKVKQDVGFFGTDNPATPVVDRVAFVVQT
                     DRSIYDNAGTPFVNLGISGAAHGTHVAGITAAHKLFDGKMAGAAPGAKLMAIKACLSTP
                     SCTSSGLIDGVLYAARNGADVVNISIGGLPALNDGNNARAELYNRTINEYNVQLFISAG
                     NSGAGANTVGDPSVATDAVSVGSYITKETWLSNYGSKTAQKQNLHGFSSRGPREDGGFK
                     PNIVAPGSAISTTPRWQAGGPVAGTYALPAGYAMFNGTSMAAPQATGAAALLVSAYKAT
                     HNGQRPTSAELRYAIQRSANYVDTLGAYEQGAGLFNTNAAWKLLDKHAVPDQVTTSVPV
                     NTVLAGLLATPGVGVGIHDREGVTAGQEYTRTYTLTRTTGHQDETYNVSWKGNDGTFTA
                     AKKVKLPLNTPVQFPVKVKAKNSGAHSAVLQLDNPETPGVDVQTLNTVFAAENFSAANK
                     FSVTKSGKIARNQSTSLFVNVPKGTTALKVDLTGGGAEAGKGQVRFLRYTPQGVGFDVN
                     SSTNCYNPDAGAGCAGGSPTSRTVASPMAGVWEIVIEARRTSDAAEAPYSVTASVLGTT
                     ISPNPDVIPSAALGAPVERAYTVTNTQASFNGRLAAGAVGSAKTARPSIANLAQQQYPI
                     TVAPGSTRLTVTIGNPADQGADLDLLVYNCTSGSCVLAGQSADADSEESVTITNPAAGN
                     WVALVDGYAVPAGTTEYDYFDVFTSAGLGTLTVTDTNADRAAGATWNATGVITPLGQPG
                     AGRVLRGELEVRTADNTVVGTGAVIVQAVS"
     gene            complement(8379..8654)
                     /locus_tag="ND450_RS38115"
                     /old_locus_tag="ND450_38115"
     CDS             complement(8379..8654)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS38115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_38115"
                     /product="hypothetical protein"
                     /protein_id="WP_253322965.1"
                     /transl_table=11
                     /translation="MSSAKPDRNRIEQAKRDGHLTVPLMISVQPGRDEEVERALVVLGA
                     TVESRDPRIGYLRAEMPVDRVEDAYLITGVSKVDLDEPLNNRLPEP"
     gene            complement(8804..9886)
                     /locus_tag="ND450_RS38120"
                     /old_locus_tag="ND450_38120"
     CDS             complement(8804..9886)
                     /GO_function="GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987414.1"
                     /locus_tag="ND450_RS38120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38120"
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_253322966.1"
                     /transl_table=11
                     /translation="MLFVVMGCSVAFALLVVEVVHRLVRRFTHSGRMYRPGQVFGALLA
                     AQISLSVYPVDAPVVLHVLGIALILAGAWLLSALISTLVDISLSRIRTDVTDNRHARRV
                     HTQVTLVRRLVLVVIGVLAVGAILMTFPGARAVGSTVLASAAVIGAVAAFSAQSLLGNL
                     ISGLQIAFSDAVRLDDVVVVEGEWGRVEDITLTYVVLHLWDDRRLVLPTSYFLKTPFEN
                     WTRTQSALLGTVELDLDWTVPVEAMRQEMRSMLEGSDLWDGRVSVLQVTQATQGFVRVR
                     ALVSAADAGKLWDLRCLTREHLVDWVHRQHAGALPQIRTKAVTGVKKAQPTSDQHTDAR
                     VFGESVDGALREQAFAGPKQ"
     misc_feature    9973..9993
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.02"
                     /tool="antismash"
     gene            10034..11035
                     /locus_tag="ND450_RS38125"
                     /old_locus_tag="ND450_38125"
     CDS             10034..11035
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635064.1"
                     /locus_tag="ND450_RS38125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38125"
                     /product="adenylate cyclase"
                     /protein_id="WP_253322967.1"
                     /transl_table=11
                     /translation="MTTTEALELVERAGSAEALFGPRTTDPDKRRQAKRLYRALASVLH
                     PDVVGPGDTRAHAASAVLTRLHHEWTHSTTVELRTRTGVYRIGEPFAVGSIANLYESDG
                     PHVVKVVRNPALNPLLHGEWQALRRLERFTDRNQWLRPFYPRLLDTSGEVAKGSRAFTV
                     LDPLKDGFVTLKDVQNAYPHGLDGRDYAWMHRRLLKALAGAHQIGLVHGAVTAENVLVH
                     PEQHGIVLAGWSFAVEEGQRLLATSKAIAYPPEVAAQEPVTAATDVHMAHALMLETLAQ
                     NEKRQRSFANGCMQDRPSRRPDAQDLLNEYDELLEELYGPRVFRPFALPEGE"
     gene            11038..12018
                     /locus_tag="ND450_RS38130"
                     /old_locus_tag="ND450_38130"
     CDS             11038..12018
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101801.1"
                     /locus_tag="ND450_RS38130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38130"
                     /product="hypothetical protein"
                     /protein_id="WP_253322968.1"
                     /transl_table=11
                     /translation="MGHGKWDDNAYAAAKTFRAAKGIADFGYTASIRSQPASSWKAAPA
                     LDPFKVAYRECRDSPDHADSTPIAVLFDVTGSMGAVPRIMQGKLGKLHGLLQRKGYLAD
                     PQLMFGGIGDADSDRVPLQVGQFESDNRMDEQLRDIFLEGNGGGQKSESYELAAYFVAR
                     HVVTDAWQKRGRKGYLFIIGDELNKPRLEAKHIRRIIGDDVHQDIDPVSVYRELARKWN
                     VYFILPNQSSYFNDDAIGEHWRAILGQNFLKLDDPGAVCELIAATIGMEEQVVDLDQAL
                     VDLAEIGSVTESKAVGKALVAVGGSKRAVVAAPLGIDGPDDVALS"
     gene            12018..13232
                     /locus_tag="ND450_RS38135"
                     /old_locus_tag="ND450_38135"
     CDS             12018..13232
                     /EC_number="6.3.4.4"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004019 - adenylosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334068.1"
                     /locus_tag="ND450_RS38135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38135"
                     /product="adenylosuccinate synthetase"
                     /protein_id="WP_253322969.1"
                     /transl_table=11
                     /translation="MNDHVIVVGLGFGDEGKGATVDALCADGSVSAVVRFNGGAQAAHN
                     VVVDGRHHTFSQFGSGTLAGVPTWLSRFVLVEPIALATESRELEAVGVTDPLSLMSIDA
                     QALLTTPFHVAANRARERARGDDRHGSCGKGIGETVWYGLLAGAAEGDVVEGQRVLGEP
                     GPAPTVGDCLNPITLRRKLDALARFYEPLIGEGPGIGELVGLYRAFADAVRITAGHEGL
                     LDAGRVVFEGAQGVLLDETYGFHPHTTWSTVVPRNARELLQGRPARVIGVTRTYQTRHG
                     AGPLPTEDPAVLARFPERHNGTGEFQGAWRAGHLDANLLRYSVDCCGGIDGLAVTHLDA
                     QGLKVATGDSLEDLSDPVAYLEDLLGVDVLVTGTGPARSDYEVRENPPHDRVDVGLGGR
                     HSAPV"
     gene            13183..13827
                     /locus_tag="ND450_RS38140"
                     /old_locus_tag="ND450_38140"
     CDS             13183..13827
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101803.1"
                     /locus_tag="ND450_RS38140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38140"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_253322970.1"
                     /transl_table=11
                     /translation="MIESTLVSVDVIALRFDPDARTVLVGVAPRALEPFAGELALPGVL
                     LGRGERLRDATTRAVTGKLGLAEESVTATGQLATFDEPSRDPRGPTLSIALWATVTGPS
                     GDVAVWHRLDDVPALAFDHDRIVADCRPLLADKLWRDVAFTAGLLGREFTTAQALDVTE
                     SLTGDRPYPANLGRTMDRVPGLERTTEHASALPKGGRPPLVWKWSSEAVRA"
     gene            complement(13805..15004)
                     /locus_tag="ND450_RS38145"
                     /old_locus_tag="ND450_38145"
     CDS             complement(13805..15004)
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020502450.1"
                     /locus_tag="ND450_RS38145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38145"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_253322971.1"
                     /transl_table=11
                     /translation="MSFSVHHYALELDYKPHSARLSGRAVLQASCPAPLTSFSLSFGPL
                     RISKLLVNGRPARYGHAGGVLNVRAAVRGAFTVEVRYSGVPKPISTPEWGDLGWDELTD
                     GSIVASQPIGAPSWFPCLDEPSSKASYHLEVTAPSPYTVVCNGVLVDGKVSGSTTRWTY
                     SMAAPMATYLATVQIGQYVEALPGVWAPSRLKRLVAHDFGRQNAMIELFSSLFGPYPFA
                     RYAVVVTDDALDVPVEAQGLSTFGANHVDGRRGSERLVAHELAHQWFGNSVGLASWEHI
                     WLNEGFASYSEWLWSEASGGRSADACAAAARDLLRRLPQDIVIGRPTRSQWFDDRVYKR
                     GALTVHALRREMGDDSFFALLREWCARNRHGVVTTEDFIALAGHRDLLDRWLFKPELPR
                     "
     gene            complement(15001..18738)
                     /locus_tag="ND450_RS38150"
                     /old_locus_tag="ND450_38150"
     CDS             complement(15001..18738)
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (17-389). E-value: 4.4e-73.
                     Score: 238.1. Matches aSDomain:
                     nrpspksdomains_ND450_RS38150_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (493-558). E-value: 3.7e-13. Score:
                     41.5. Matches aSDomain: nrpspksdomains_ND450_RS38150_PCP.1"
                     /NRPS_PKS="Domain: TIGR02353 (577-1241). E-value: 3e-225.
                     Score: 741.5. Matches aSDomain:
                     nrpspksdomains_ND450_RS38150_TIGR02353.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NAPAA:
                     TIGR02353"
                     /gene_functions="biosynthetic (rule-based-clusters) NAPAA:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005153488.1"
                     /locus_tag="ND450_RS38150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38150"
                     /product="Pls/PosA family non-ribosomal peptide synthetase"
                     /protein_id="WP_253322972.1"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-61, bitscore:
                     207.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.8e-09, bitscore:
                     35.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR02353 (E-value: 4.5e-223, bitscore:
                     741.5, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFTAGEAPSPRTLLDILRASAETHPNALAVDDGTTALTYRALITE
                     VLELKDKLAAEGVGVGDRVGIRVPSGTVDLYVSILATLAAGAAYVPVDFEDPDERAELV
                     FGEAQVGAVLGEGRSLVRHGSTLGVTGEPGLDDDAWIIFTSGSTGRPKGVAVTHRSAAA
                     FVDAEARLFLRDEPIGPEDRVLAGLSVAFDASCEEMWLAWRYGACLVPAPRSLVRTGMD
                     LGPWLVEQEITVVSTVPTLAALWPVEALDDVRLLIFGGEACPPELAERLAVPGREVWNT
                     YGPTEATVVACAAQMTGQGPVRIGLPLDGWDLVVVDAQGEVVPMGESGELVIGGVGLAR
                     YLDAEKDAQKYAPLPSMGWDRAYRSGDVVRAEPEGLVFLGRADEQIKLGGRRIELGEVD
                     AALGALPGVAGAAAAVRTTRGGNQILVGYVVTDGEFDQDAAVEQLRTELPAALVPLIAV
                     VETLPTRTSGKVDRAALPWPLESMDTAGVVFSGLEGWLAERWAEVLGSGPASEDANFFA
                     SGGSSLGAAQLVSMIRTRYPSTSVQDIYQNPTLYKLARKLESYGETAEVREVAPTPRWT
                     GVVQTLLMVPLLTIAGARWVVALTALSNVLGWTSVSWWWVAAGFVVFLSPAGRLAISAG
                     GARLLLRGVKPGTYPRGGSVHLRLWTAEMLAQMSRATELSGSWVTHYARALGAKIGEGA
                     DLHSLPPVTGMLKVGRGAAVEPEVDLSGWWIDGDRLRIGRVRIGAGATVGARSTLFPGA
                     RIGKKAEVAPGSGVRGSVPTGQRWAGVPAIREGKAARSFPSRRPERSRFWNLMYGLSSG
                     LLAALPLLAAAPALLYVLRRPVTLTSALWDVPVASAIWFGSYALIVLVAVRLLGIGMRE
                     GYYPVHSRVAWAAWTTERLMNNARSALFPLYASLFTPVWLRLLGMKVGRGVEASTVVAL
                     PKMTRVGDGAFLADDTMVASYELGGGWLRIATARVGKRAFLGNSGMTAPGRAVPKGGLV
                     GVLSAAPKRAKAGSSYLGMPPMKLPRAAEVSDQSRTFDPPKHLMWARALVELCRFVPVM
                     LNVALVVGVLFALKEFGLWASGLVLLGAGVAACLVAVVAKWTLVGRFKTREYPLWSAFV
                     WRNELADTFVEVLAVPWLIGFSGGTPIMNLWLRSLGASVGRGVWCESYWLPEADLVELG
                     AGATVNRGCVVQTHLFHDRILRMDRVELGAGSTLGPHGIVLPGASVGDHTTIGPASLVM
                     RGEDVPSGTRWLGNPISAWT"
     aSDomain        complement(15016..17007)
                     /aSDomain="TIGR02353"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS38150_TIGR02353.1"
                     /evalue="3.00E-225"
                     /label="ND450_RS38150_TIGR02353.1"
                     /locus_tag="ND450_RS38150"
                     /protein_end="1241"
                     /protein_start="577"
                     /score="741.5"
                     /tool="antismash"
                     /translation="VVQTLLMVPLLTIAGARWVVALTALSNVLGWTSVSWWWVAAGFVV
                     FLSPAGRLAISAGGARLLLRGVKPGTYPRGGSVHLRLWTAEMLAQMSRATELSGSWVTH
                     YARALGAKIGEGADLHSLPPVTGMLKVGRGAAVEPEVDLSGWWIDGDRLRIGRVRIGAG
                     ATVGARSTLFPGARIGKKAEVAPGSGVRGSVPTGQRWAGVPAIREGKAARSFPSRRPER
                     SRFWNLMYGLSSGLLAALPLLAAAPALLYVLRRPVTLTSALWDVPVASAIWFGSYALIV
                     LVAVRLLGIGMREGYYPVHSRVAWAAWTTERLMNNARSALFPLYASLFTPVWLRLLGMK
                     VGRGVEASTVVALPKMTRVGDGAFLADDTMVASYELGGGWLRIATARVGKRAFLGNSGM
                     TAPGRAVPKGGLVGVLSAAPKRAKAGSSYLGMPPMKLPRAAEVSDQSRTFDPPKHLMWA
                     RALVELCRFVPVMLNVALVVGVLFALKEFGLWASGLVLLGAGVAACLVAVVAKWTLVGR
                     FKTREYPLWSAFVWRNELADTFVEVLAVPWLIGFSGGTPIMNLWLRSLGASVGRGVWCE
                     SYWLPEADLVELGAGATVNRGCVVQTHLFHDRILRMDRVELGAGSTLGPHGIVLPGASV
                     GDHTTIGPASLVMRGEDVPSGTRWLGNPI"
     aSModule        complement(15016..18687)
                     /complete
                     /domains="nrpspksdomains_ND450_RS38150_AMP-binding.1"
                     /domains="nrpspksdomains_ND450_RS38150_PCP.1"
                     /domains="nrpspksdomains_ND450_RS38150_TIGR02353.1"
                     /locus_tags="ND450_RS38150"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(15118..15150)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS38150_0006"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="ND450_RS38150"
                     /protein_end="1207"
                     /protein_start="1196"
                     /score="-3.1"
                     /tool="antismash"
                     /translation="GSTLGPHGIVL"
     aSDomain        complement(17065..17259)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS38150_PCP.1"
                     /evalue="3.70E-13"
                     /label="ND450_RS38150_PCP.1"
                     /locus_tag="ND450_RS38150"
                     /protein_end="558"
                     /protein_start="493"
                     /score="41.5"
                     /tool="antismash"
                     /translation="GWLAERWAEVLGSGPASEDANFFASGGSSLGAAQLVSMIRTRYPS
                     TSVQDIYQNPTLYKLARKLE"
     CDS_motif       complement(17545..17607)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS38150_0005"
                     /evalue="6.00E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="ND450_RS38150"
                     /protein_end="398"
                     /protein_start="377"
                     /score="28.2"
                     /tool="antismash"
                     /translation="FLGRADEQIKLGGRRIELGEV"
     aSDomain        complement(17572..18687)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS38150_AMP-binding.1"
                     /evalue="4.40E-73"
                     /label="ND450_RS38150_AMP-binding.1"
                     /locus_tag="ND450_RS38150"
                     /protein_end="389"
                     /protein_start="17"
                     /score="238.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RASAETHPNALAVDDGTTALTYRALITEVLELKDKLAAEGVGVGD
                     RVGIRVPSGTVDLYVSILATLAAGAAYVPVDFEDPDERAELVFGEAQVGAVLGEGRSLV
                     RHGSTLGVTGEPGLDDDAWIIFTSGSTGRPKGVAVTHRSAAAFVDAEARLFLRDEPIGP
                     EDRVLAGLSVAFDASCEEMWLAWRYGACLVPAPRSLVRTGMDLGPWLVEQEITVVSTVP
                     TLAALWPVEALDDVRLLIFGGEACPPELAERLAVPGREVWNTYGPTEATVVACAAQMTG
                     QGPVRIGLPLDGWDLVVVDAQGEVVPMGESGELVIGGVGLARYLDAEKDAQKYAPLPSM
                     GWDRAYRSGDVVRAEPEGLVFLGRADEQIKLG"
     CDS_motif       complement(17719..17769)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS38150_0004"
                     /evalue="2.40E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="ND450_RS38150"
                     /protein_end="340"
                     /protein_start="323"
                     /score="16.7"
                     /tool="antismash"
                     /translation="PMGESGELVIGGVGLAR"
     CDS_motif       complement(18106..18132)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS38150_0003"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="ND450_RS38150"
                     /protein_end="211"
                     /protein_start="202"
                     /score="-3.0"
                     /tool="antismash"
                     /translation="WRYGACLVP"
     CDS_motif       complement(18265..18324)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS38150_0002"
                     /evalue="2.00E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="ND450_RS38150"
                     /protein_end="158"
                     /protein_start="138"
                     /score="29.4"
                     /tool="antismash"
                     /translation="AWIIFTSGSTGRPKGVAVTH"
     CDS_motif       complement(18460..18501)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS38150_0001"
                     /evalue="5.20E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="ND450_RS38150"
                     /protein_end="93"
                     /protein_start="79"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LATLAAGAAYVPVD"
     misc_feature    18770..18785
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    complement(18820..18837)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.43"
                     /tool="antismash"
     gene            complement(18839..20572)
                     /locus_tag="ND450_RS38155"
                     /old_locus_tag="ND450_38155"
     CDS             complement(18839..20572)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025067.5"
                     /locus_tag="ND450_RS38155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38155"
                     /product="DUF4153 domain-containing protein"
                     /protein_id="WP_256557371.1"
                     /transl_table=11
                     /translation="MEGAATAGDKPQPAQPEAAAESKPAADTPDTAEAKPTADKRVAQA
                     KPTTEAKPVAEPAPAAQPTPAVQPAAVVTATLPPPSPWQGPPRYPAATPAMAAPGVPFM
                     PWWRPPTTGAPGKALIAGLAAGLAGAFLAVPNNGIGWFLAGLVGVGAVLFYSGRPTVER
                     ALWLAAALAFLAMAFLRAAEWVFPLSLLASMLCGSIAMAGGKTVRGLVFGAVGVGLGAF
                     RSIPWVAKGVKKRGPIGIRPFVSVGVALVLLLVFGSLLAGADKGFNDFLEALVPDLNLD
                     DWVQQAFFGVVAAFGALGACYLVAAPPEIDEDAEQKPGSLRLKDYGLPVGVLVLLFTGF
                     VGTQLAVLFGGEAYVMKTAGVTFAEYARSGFWQLLWVTILTLGVIAGVARFAVKKTQKD
                     QLWLRVLLGSLAVLTLVIVASALSRMWFYQQAYGWTVLRLLVASCEVWLAVVYVMVIAS
                     GISLRANWLPKAIVATGAAFFLVVVAMNPERVVADYNVSRFEATQKIDTYYLSQLSEDA
                     APALVRLPEHERSCALRWLKNRTPEKDWREWNLARHNAKKSLESVVVTEVTCEGAYSGE
                     R"
     gene            complement(20823..21821)
                     /locus_tag="ND450_RS38160"
                     /old_locus_tag="ND450_38160"
     CDS             complement(20823..21821)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015804898.1"
                     /locus_tag="ND450_RS38160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38160"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_253322973.1"
                     /transl_table=11
                     /translation="MRRVLELIDMLPRPLDSVRSIKLKLGIVIVVSGCVSFAYFRYVTG
                     WLPPRTTLIALVLGLLTSQLLAHGMTSPLREMTSAARSMASGDYSRSVRATSSDEVGQL
                     AEAFTVMAADLAAADQQRRELIANVSHELRTPISALQAVLENVVDGVASPDAATMRTAL
                     AQTERLGRLVTELLDLSKIDAGVLSLNRETLSVSSLVADVVAEAAVAAPAASFSIDVPG
                     DLTVLADGERLHQVLVNLVDNAARHGPTGGLVSVSGYASGSCVVLEVRDEGPGIAVADR
                     SRIFERFTRGERAGGGGTGLGLAIARWVVDLHGGTIAVVDPGSCIRVTLPR"
     gene            complement(21818..22492)
                     /locus_tag="ND450_RS38165"
                     /old_locus_tag="ND450_38165"
     CDS             complement(21818..22492)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104789.1"
                     /locus_tag="ND450_RS38165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38165"
                     /product="response regulator transcription factor"
                     /protein_id="WP_253322974.1"
                     /transl_table=11
                     /translation="MTGQRRVLVVEDDITIAESVAARLRAEGFEVAVAHDGPSGVAVAA
                     AFGPDLVVLDVMLPGYDGLEVCRRIQASRSVPVLMLTARGDETDLLVGLAVGADDYLTK
                     PFSMRELAARVHVLLRRVSRAVSSRSLELGDLLIDLSSRRVSRSGVEAHLTPTEYDLLV
                     FLAERPSAVQARERLLAEACGWHEGASSRTVDSHVKALRRKLGADLIRTVHGVGYALEV
                     PR"
     misc_feature    22539..22553
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            22577..24748
                     /locus_tag="ND450_RS38170"
                     /old_locus_tag="ND450_38170"
     CDS             22577..24748
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0043139 - 5'-3' DNA helicase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032508 - DNA duplex unwinding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009946223.1"
                     /locus_tag="ND450_RS38170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38170"
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="WP_253322975.1"
                     /transl_table=11
                     /translation="MNVLEAVLERITYANEDNGYTVAKVDTGRGDLVTVVGALLGAQPG
                     ESIRMRGTWGSHPQYGKQFHVDDYTTILPATIQGIRRYLGSGLIKGIGPVLADKIVTHF
                     GVSALDVIENEPERLIEVPKLGPKRTKLIADAWEEQKAIKEVMVFLQGVGVSTSLAVRV
                     YKQYADKSIDVVRDEPYRLAADVWGIGFKTADVIAKAVGIPHDSPQRVKAGLQFTLSEA
                     TTDGNCYLPEQALIADAIKILQVDTGLVIDCLAELVEEEGVVREELPDDEIAIYLVPFH
                     RAEISMAAQLKRLLHADTDRMPSFATVDWDKAFAWLGTDLEEHQAAAVKLALTQKVAVL
                     TGGPGCGKSFTVRSIVRLAQAKRAKIVLAAPTGRAAKRLTELTGHEARTVHRLLELKPG
                     GDAAYDRDHPLDADLVVVDEASMLDLLLANKLVKAVPPGAHLLLVGDVDQLPSVGAGEV
                     LRDVLAQGSPVPNVRLTHIFRQAQESGVVTNAHRINSGDYPIVQGMPDFFLFSTDEAEE
                     AANLTVDVVANRIPRKFRLDPRKDIQVLAPMHRGPAGAGALNTVLQEALTPSRDNLPEK
                     RFGGRVFKLGDKVTQIRNNYDKGKNGVFNGTLGVVIALDTVEQKLTVRTDEDEEVDYEF
                     SELDELSHAYAMTIHRSQGSEYPCVVIPITTSAWMMLQRNLLYTAVTRAKKLVVLVGSK
                     RAIGQAVRTVGAGRRHTALAHRLRTAQAF"
     misc_feature    24969..24984
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.73"
                     /tool="antismash"
     misc_feature    24971..24985
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.19"
                     /tool="antismash"
     misc_feature    complement(24972..24987)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            25095..26375
                     /locus_tag="ND450_RS38175"
                     /old_locus_tag="ND450_38175"
     CDS             25095..26375
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018685052.1"
                     /locus_tag="ND450_RS38175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38175"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_253322976.1"
                     /transl_table=11
                     /translation="MRTAVALLACLALLLSPAAAPAEGPQATHLLRVPAPMGDAAQRLL
                     ALGYDVLEQRDGDDLFVVGDPRTADELRADGFASTAEKVMAPSHRQPRSLADTTYYGGY
                     RTITAHLAHLDEVAKAHPGLATVVDYGASWRKTQGSGGYDLKAICITRKSPGDCALTPT
                     APKPRLFVMGQLHAREITTGDMAWRYVDDLVGSPDLTAMLSELEVWVVPIANPDGVEIV
                     ESGGDTPVLHRKNANGTCSSGPRGVDLNRNAGSHWGEVGSSRNKCAETYQGPRADSEVE
                     VQALESLWRKLYRDTRAPGDTAAASADTTGAVISMHSYGDYVLFPWGWSTQKTGNDAAL
                     RKMANDMAARSGFTAGQPGEVLYNSSGVTDDWVYDDLGVPSFVWEIGASSGRCGGFLPP
                     FSCQADVHWPKVRPMLVSAMNAAKRPY"
     gene            26382..27470
                     /locus_tag="ND450_RS38180"
                     /old_locus_tag="ND450_38180"
     CDS             26382..27470
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.5"
                     /locus_tag="ND450_RS38180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38180"
                     /product="serine hydrolase"
                     /protein_id="WP_253322977.1"
                     /transl_table=11
                     /translation="MGAWGNACSPPSPPSACSSPGPRSPTTPESTAGPSRKASTNWSRS
                     GSPRAPRPGSPTAGPASPRSGTAERNDPRPVPLNGRFRAGSITKSFTSTTVLHLAGEGR
                     ISLDAPVDRYLPGLVDRRITVRHLLQMTGGLYNYTDALAFDPQGFEEIRYRQWQPRELV
                     EISTSRPLDFEPGTKWNYSNTNYVVLGLLIEQVTRRPYERVVEQRILKPLRLNDTTFPG
                     GDTEIRGPHAHSYGIVNGRTIDTTRWNPSVFWAAGDVITTTRDLDTFYTALLTGKLLEP
                     AQQSELTKTTAVSTDYGLGVFVEKAPCGTTIIGHPGGVPGFSTYAYSTPDLQRRVELSL
                     SAGVGTGDPASAYGKLINEIFC"
     misc_feature    complement(26416..26425)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            27585..28682
                     /locus_tag="ND450_RS38185"
                     /old_locus_tag="ND450_38185"
     CDS             27585..28682
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225511.1"
                     /locus_tag="ND450_RS38185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38185"
                     /product="serine hydrolase"
                     /protein_id="WP_253322978.1"
                     /transl_table=11
                     /translation="MGIRLAATATATAASLLVLTTGGVASADTSSADRAVVQQALDEIT
                     RSGAALGVQARVVDGRQRFTATSGKADLNSTRPVPDNGRFRVGSITKTFVSTVLLQLAG
                     EGKVDLDAPVVRYLPGLVDQRITVRQVLQHTSGLFNYTNALPLSPEEFEKIRYKHWTPQ
                     ELLALSTAQPLDFEPGTQWNYSNTNYVVAGLLVEKLTGKPYEKAVEQRILKPLRLRDTE
                     VPGDDPNIRGPHARGYWTVAGKPSDITRINPSVAWAAGEMISTTRDLDTFITALSRGEL
                     LKPAQQAEMSRTTAVSPQYGLGLQVETLPCGTKVWGHGGGIPGYSSQLLSTPDSKKRFE
                     LNATSGPTEGNPGEAFNKLLTEVFC"
     gene            complement(28745..30364)
                     /locus_tag="ND450_RS38190"
                     /old_locus_tag="ND450_38190"
     CDS             complement(28745..30364)
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003078139.1"
                     /locus_tag="ND450_RS38190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38190"
                     /product="glycosyl hydrolase family 18 protein"
                     /protein_id="WP_253322979.1"
                     /transl_table=11
                     /translation="MSKFRWHLAALFAAVAAMVLGIVVVPAASGAGGVSATFSKGSDWG
                     TGFEGKYTITNNSTAALTSWTVEFTLPANHRVTSLWDGSYTTSGQTVTVKNTWNGNIGV
                     GGSVSFGFNGAYSGTFGAPTNCKLNGGSCEAGGTNPTTTTTTSTTTSTTTTTTTTTTTG
                     PPPPPGKINLGYFAEWGVYPARNYQVKNIDTSGSASKLTHINYSFGNVVGGKCTIGETF
                     PAIEKSMTAAESVDGVADTWDAPVRGNFNQLLKLKKKYPHLKVLYSFGGWTWSGGFGEA
                     SRNLPAFVDSCYNLLKDPRWAGLFDGIDIDWEYPNACGLSCDTSGPAAFANMAQALRNK
                     FGQNFLVTAAITADGSAGGKIDAADYGPASQYLNWYNVMTYDYFGAWAAQGPTAPHSPL
                     TSYNGIPTAGFNSEAAISKLRSKGVPASKLLLGIGFYGRGWTGVTQAAPGGTATGPAPG
                     TFEQGIEDYKVLKTKCPATGTIAGTAYAFCNGQWWSYDTPQTITSKIQWARSQGLGGAF
                     FWELTGDTANGELITAMKNALG"
     misc_feature    complement(30398..30413)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.74"
                     /tool="antismash"
     misc_feature    30421..30436
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.49"
                     /tool="antismash"
     misc_feature    30461..30472
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.26"
                     /tool="antismash"
     gene            30601..31431
                     /locus_tag="ND450_RS38195"
                     /old_locus_tag="ND450_38195"
     CDS             30601..31431
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="ND450_RS38195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38195"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_253322980.1"
                     /transl_table=11
                     /translation="MPKRFSTARGREFGDAVRAALSATGMTAREICEKIDWDPGKLSDL
                     VNGKGGSSEVDLAVLLGFCRTPPDEREHLLRIHRQTDTKDWWQNHADQRPFEMRTFLEH
                     LWKAKEYVCWMPLLVPGLLQLPEYRRPLCIASATFPKDQVEVRLAAHAAMQEVFRQRLA
                     CTFYIHEQALLLPIGGEDVLRAQLHHLLQMLVRPYIEIRILPTSVGAHAGLSGGFELMR
                     FDRFEPVVFLESENANFIIERKDSVDDYEEVLKALDRVALDAGESQRRISEIAT"
     gene            31441..31620
                     /locus_tag="ND450_RS38200"
                     /old_locus_tag="ND450_38200"
     CDS             31441..31620
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="ND450_RS38200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38200"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_253322981.1"
                     /transl_table=11
                     /translation="MWRKSSYSANLNNCVEVGRGVGIRDTKAPATHLAVAPGSWSAFLL
                     FVKAGKFAPSGQTP"
     gene            31663..32310
                     /locus_tag="ND450_RS38205"
                     /old_locus_tag="ND450_38205"
     CDS             31663..32310
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.5"
                     /locus_tag="ND450_RS38205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_38205"
                     /product="HAD family phosphatase"
                     /protein_id="WP_253322982.1"
                     /sec_met_domain="HAD_2 (E-value: 4.7e-21, bitscore: 74.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLATVFNLDGTLVDSTATWNQVISAVAARHDRSWTRADWAAIE
                     GRTTWGAYLADRCDGLTPERAVSECVDGMVDAIARGTFGLQPGAAELVALAAELGPVGL
                     VSAAPRRYVRAAASASGILRHVQVIVSGEDVQNGKPAPDPYLVAARKLGLEPGQCLAVE
                     DSEPGVRSAHAAGMTVLAITSAHTEAAQHVPDAKLAAKAMCRLWVDVYALNR"
ORIGIN
        1 cgttcatgcc gcgggccagg tccgcgaccg tgccggcctg gatgaactcc ttggacttct
       61 gggcgaacgc ctcgaccggc gcgaccgcac ccggcagcgc gcgcttgagc acggccctgg
      121 tgtccttgcc cgtgaggtcg gggttctgct cggagcccga cagcgcgaac tccttgccga
      181 tgatcctctt gttcagcacg aaccacgagt gctcgtggcc gtgcgtggtg atgtgctgca
      241 acgcacccag cgcgtcgaag cccgggaaca gcgggatcgg cagccgcttg ccgtccgcgt
      301 cgagccacag cggcgacggg ccgggcagga tgcggatgcc gtgccgcgac cacaccgggg
      361 cgtagttcgc gatgccctcg gggtagtgcc acatgcggtc ggcgttgatg atcgcgccgc
      421 cggccttctg cgtgatctcc atcatcgagc cgtccacgaa gtccggcaca ccggagagca
      481 tgaacttcgg cggcgtgccc atccgctcgg gccagttcct gcgcaccagg tcgtggttcc
      541 cgccgatgcc accggacgtg acgacgacgg cctgggcgct cagcgagaac tcgccgacgg
      601 cggtgcgcga gctcggttcc gcgcgagcga ccgaggacgg ctccagcacc tcgccggaca
      661 cgccgtcgca cacgccgttg gtgacgttga tgcccgtgac cttgtggcgg aacttcagcg
      721 tcacgagccc cttcgccacg ccctcgcgga cccggcgctc gaacggctcg acgatgccgg
      781 gtccggtgcc ccacgtgacg tggaagcgcg gcaccgagtt gccgtgcccg tccgccaggt
      841 agccgccgcg ctccgcccac tgcacgagcg ggaaccagcg cacccccatg ttgtgcaacc
      901 aggagcgctt ctcgccggcg gcgaagtcca cataggcctg tgcccacaac cggggccagt
      961 ggtcctcgtc ccggtcgaac gcggccgagc ccatccagtc ctgcaacgcc aggtcgtgcg
     1021 agtccttgac ccgaagcctg cgctgctctg gggtgtcgac caggaacagc ccgccgaacg
     1081 accaccacgc ctggccgccg atcgacgcct ccggctcctg gtcgaggagg atgaccttgc
     1141 gacccgcgtc ggcgagttct gcggtcgcga cgagacctgc gaggcccgcg ccgacgacga
     1201 tgacatccgc gtcatgtgcc atcgggtgag tctagagcgg cccctggtca cgcacgagac
     1261 ctgagtcaat ttcacttttg gggagggatg cgtacccctg agggtgccgc cgaccgccac
     1321 taccggtgag gggggttacc ggagtgccgg ccgacggcgg gtcgaccgct gcgcgagcac
     1381 gcgacgcctg cggaaggact gatccgacct gggggtgtcg gacagtcccg gcgtgcagct
     1441 ccagcgcgag cggccaacca cttgttgaac gtacaaccgg accgtcgtgt tccggtcgcc
     1501 tttcgctgtg accaggctca attccttcag gtttccttca ggttcggccg ggtggctcac
     1561 cacgtgtgac agcccgcatg ccgacgatca cgagtctcgc cgacctggtg gggctcatcg
     1621 acgacgacat ctacgtgcgc tggtccaagg ggccggacgc cgacgccgcc tccacctcgc
     1681 gcgactcgct gaccggtgtg gagctgccgg gcctgtcggc gagcccgccg cgcatcgagc
     1741 cgtggtggga cgaccgctcg cacgagctgt gggtggcgcg ccgcctgttc gactaccgcc
     1801 acctgcgcga cctgcgcggc ccggacgtcc gcgcctgggt gctgcgcggc gaggaggtgg
     1861 gccgcggccc cgacaacgag ccgctggtcc ggtgccggga accactcgcc tgggtggacg
     1921 acgaggcgtt gcgggagtgc gtcgagctgg tcggcgccca gcactccgac gagtgggggc
     1981 cgttggaccg gtctagctca ggtcgttgag cttgcgttcc gccgccttgc gggccttctc
     2041 cgcgccggac gtgacccgct tggcgtcctc cagccgttcc gcggcccggt cgaacgcccg
     2101 ttgcgccgcc agctggtccg cctgcgcctc cccgagggcc tgttcggcct cgtccagcgc
     2161 ctgctgcgcc tcggcccgct tgcgctcctc ccgctcccgc cgcttgcggg cgagcgcgtc
     2221 ctcaccgtcc tgcgcgggct cgggctccgg cagcgcgaac ccgaacccgg agtactcgag
     2281 cgccttcgtg aggtggccgt cgcgcacctg ctcggcggac tcggggtcgg ccatcgcggc
     2341 cgtcagcgtg ttgcggacct gcgtgacggc gtcgtccgcc aacggccccg tcagttccag
     2401 cgtgcggtag accagggcct ccacgagctc cttgcgccgc cggccgagtt cccgcatggt
     2461 cagcttcgcc gtggagaggc ccagcgcctc ctccaggccc tcgggggcgt cccggacgag
     2521 cttgttgacg gcccaggcgc ccacggtggg cttgcggagg tcggcgatgg ccttcgcgag
     2581 gtccttgtcg ccggcctgct tggccgcggc gttgcgggcc gcggtgaagt ccttcggggg
     2641 cagcccgtag agctcgtcgg cgaccggctt caggtccatg ggcgcaaggt agcgcctgac
     2701 cggccctcag tcctgccgaa cgtcgtgatg accggctccg agcatgcgct cggcgtgggt
     2761 gtacagacgt agggcttcgc cactggcttc accgccgttc catccgaagc ccggagccat
     2821 gtgcacctcc tgcaagactg cgatgacgtc ctgataccgg ccggccgcgt cgttcgcgcg
     2881 acccaacgcg atcgccgcct tgatcgtgtc cgggtcggtc gcgcccagcg cgtctctcat
     2941 gcggcggaaa actcgctcga acgcgtccgc gacctccccg gctgacatct cagacctgat
     3001 ggtgaccacg atctcggtca ggttcagctc ctcctggagc gccctgcggg tcagccagag
     3061 gtggatcgag accaccgccc tcgtgacggc ggccgtcgct ctggagtcac ttcgtccgat
     3121 cgtgttgcgg accagcgcgg cggagtgacc ggccagtatc tcgttgaagt ccaggcggta
     3181 ctcacgaagg ctcggagcct tgtcgaggct ggcttcgaga acgcccgcca ctctctccaa
     3241 ggcggcgtcg taagtgccgg ccgcctgacg gcagtcacgg atgatcttct ggaccagacg
     3301 atgcgttcgc acggaggaac ggtcggcgta ctcgatgagt gaagactcgt agagcagcgc
     3361 cagatgatcg tcggtctcct cgccgagcag ttcgcgcgac acaccttctg gcgccagcag
     3421 tgccagcgtt tcgaggactg cactgtcctc gaacggctca agcgcgatca ggactgcctt
     3481 cgctgcgctg agtggatgat cgtcaccgtc gcgccggcgt aggtggttct ccgcaggaaa
     3541 ttgccggaaa cgcgccagat aggtttggta gtcccatccg gatgtccgaa tccgggccgc
     3601 cgcctgagcc agcgccaagg gcaggccacc gacctcgcgt gcgagttcag cggcaccggc
     3661 gtcgtgggcg atcccggtgg cggctcgaag gaaccgcaac gagatctcct cgtcgaatgc
     3721 ctccaccagc accccgcgat gctccagctg tgatccgcga gcagtgctgg tgatcaccat
     3781 ctgggtctct cccgccaccg gtaggtactc gcggactgcg tccagcgaca cggcattgtc
     3841 gaacaccagc aaggaccggc ctggcctcgt ccgtaggtgg ttgcgtacgc gtgctgcggt
     3901 cagcttggag ccgtcctcgg gccggtagag gctgagccgg tcgcccagct cgaccattcc
     3961 ggcttcgatc ccttccttgt tctcggcccc gatccaagcc accaaccaac cgtcggacac
     4021 ccgctgacgt gcgtaagccg cagccagctg agttttcccc accccgcgtt gaccggtgat
     4081 cacgcagaca ggtccaggtt cgtgcaacac agcgagcccg ggaggcgttt ggaagtggag
     4141 cggctcgtga ggaatcaggc cggtgacgac ctggtccgca cgaacggcgg tcacaacgga
     4201 gggcaggcct cggaactccg cgcgtaccag cggaccgtca tgttgatttg gcaccaacca
     4261 atgctaggcc cgcggatcgg gtacacagga gggagacatg cacaccaggt ggagatgggt
     4321 cctgttcggc ctcggcatcg ccgtggccgc cgtcggtccg ctcgcggcca aggacggccc
     4381 ctggtacgcg tacctcttcg gcggcctgtg gttcctcatg ggcgcgacgg tcgcgtggcg
     4441 gaccttcaac ctcggcacga agctcacggc cgagggcctc acgtcgcacg ggctcgacca
     4501 ccagaccacc gtcgagtggt gcgacgtcca ggggttcgaa ccgaagcgca gccggaacct
     4561 ggtgctgttc cacacgatca cgccggcggc gcagttgcgg cgcggaacgc acgtgctgac
     4621 cgagctgagc ctgctctcga tcaaaaagga cgtcgtgccg cggcggaccg cgcagcaggt
     4681 gacggaactc gagcaggcgc tcgcgaagca ccgcaaaacc tgctcggtgt gcgggaccca
     4741 gcccaaagcg ctcgcgccgc cgcaggggat cgtcggacgg ctgcgcgcga gattacgcga
     4801 gctaatgggc ggaaatggtg accggtccat cgtccgttga cgggattcgt tacacggcaa
     4861 cgacgttcac cgttgacgca gccttgacat tcccctccat cagctcttga ctggagggcg
     4921 gttgctcgtt ccacggcgta aatgaaacgc gcagcactaa aagtgcgccc tttcaagcct
     4981 ctgaacagtc caatgtggaa ccaacaattg ctctgttccg acgattgccc ctcgcgaggc
     5041 gaagagatgt gcttcggagc actctttacc ccacgaaggg cacatgcgcc gtgaagaact
     5101 ggagacgccg caccggcacg gtcttgctga ccgcggtgct gggcactacc gggttcggct
     5161 tcgccgccac ccctgccatc gcgcagaacg catctcagca acagcagccg gccgctgaca
     5221 agcagctgga caagcaggac cgcgcactcg tcgagaaggc cgcccaggag ggcaagccga
     5281 ccgtcgacct gctggtcgcc gccgaggacg gcaagaccga cgccgcggtc aacgacctca
     5341 aggcgctcgg cgccacggtc cagaagaccg agaaggacgt cgactacgtc aaggtgacca
     5401 tcccgcgcga gaacgcggag aaggccgcca agctggcctc ggtcagcacc gtggacgtcg
     5461 acgggctcgt cgcgctcgac aacccgcgcc ccgagggcat ggagaacccg gccccgcaga
     5521 aggcgccgga cgcgaagacg ccgcgcacga acccgtacat gccgacgcag gacacgcagg
     5581 cggcgcagtt cgccaccgcg cactcgaagt gggacggccg cggcaccacc atcgcggtga
     5641 tcgactccgg catcgacctc gacacgccgg ccctgcagac gaccagcacc ggtgagcgca
     5701 agatcatcga ctggtacaac gcgaacgcca cgaactccgg cgacggcacc tgggtcacga
     5761 tgaccaagac cggccgcacc ggcacgttcg tcgagggcgg caagacctac aaggcgcccg
     5821 ccaccggcgg tccctactcg ttcggcctct tcagcgagac cgcgggcgac ctgaacctct
     5881 ccaacagcga gaccggcggt gacatcaacc gcgacggcga ccgcacggac tcgttcggtg
     5941 tcatccagga catcacgacg aaggaagtct tcgtcgacac cgatggtgac ggcgacttca
     6001 ccaacaacaa gcgcatgatc gactacaagg tcaagcagga cgtcggcttc ttcggcaccg
     6061 acaaccccgc gacccccgtc gtcgaccgcg tcgcgttcgt cgtgcagacc gaccgctcga
     6121 tctacgacaa cgcgggcacg ccgttcgtca acctgggcat ctcgggcgcc gcgcacggca
     6181 cgcacgtcgc cggcatcacc gccgcccaca agctgttcga cggcaagatg gccggtgcgg
     6241 cgccgggcgc gaagctcatg gccatcaagg cctgcctctc cacgccgtcc tgcacgagct
     6301 ccggtctcat cgacggtgtc ctctacgccg cgcgcaacgg cgccgacgtc gtgaacatct
     6361 ccatcggtgg cctcccggcc ctcaacgacg gcaacaacgc ccgtgcggag ctctacaacc
     6421 gcacgatcaa cgagtacaac gtccagctgt tcatctcggc gggcaactcg ggcgcgggcg
     6481 ccaacaccgt cggtgacccg tcggtcgcca cggacgcggt gagcgtcggc tcgtacatca
     6541 ccaaggagac ctggctctcc aactacggct cgaagaccgc gcagaagcag aacctgcacg
     6601 gcttctcgtc gcgcggcccg cgtgaggacg gcggcttcaa gccgaacatc gtggcgcccg
     6661 gctcggcgat ctccaccacg ccgcgctggc aggccggtgg cccggtggcg ggcacctacg
     6721 ccctcccggc cggctacgcg atgttcaacg gcacgtcgat ggccgccccg caggcgaccg
     6781 gtgccgccgc gctgctcgtg agcgcgtaca aggccacgca caacggccag cgcccgacca
     6841 gcgccgagct gcgctacgcg atccagcgca gcgcgaacta cgtggacacc ctcggtgcct
     6901 acgagcaggg cgcaggtctg ttcaacacca acgccgcgtg gaagctgctg gacaagcacg
     6961 ccgtgccgga ccaggtcacc acgtccgtcc cggtcaacac cgtcctcgcc ggcctgctgg
     7021 ccaccccggg cgtcggtgtc ggcatccacg accgcgaagg cgtgaccgcg ggccaggagt
     7081 acacccgcac ctacacgctg acccgcacca cgggtcacca ggacgagacc tacaacgtgt
     7141 cctggaaggg caacgacggc acgttcaccg cggccaagaa ggtcaagctg ccgctgaaca
     7201 cgccggtcca gttcccggtc aaggtcaagg cgaagaactc gggcgcgcac agcgccgtcc
     7261 tgcagctcga caacccggag acgcccggcg tcgacgtgca gaccctgaac acggtgttcg
     7321 cggcggagaa cttcagcgcc gccaacaagt tctcggtcac gaagtccggc aagatcgcgc
     7381 gcaaccagtc gaccagcctc ttcgtgaacg tgcccaaggg cacgaccgcg ctgaaggtcg
     7441 acctgaccgg cggcggcgcc gaggccggca agggccaggt ccgcttcctg cgctacaccc
     7501 cgcagggcgt cggcttcgac gtcaactcgt cgaccaactg ctacaacccc gacgcgggtg
     7561 ccggttgcgc cggtggctcg ccgaccagcc gcacggtggc cagcccgatg gccggtgtgt
     7621 gggagatcgt gatcgaggcc cgtcgcacct ccgacgccgc cgaggcgccg tactcggtga
     7681 ccgcgtcggt gctcggcacg accatcagcc cgaacccgga cgtcatcccg tccgcggcgc
     7741 tgggtgcccc ggtcgagcgc gcgtacaccg tcacgaacac gcaggccagc ttcaacggcc
     7801 ggctcgcggc gggtgcggtc ggcagtgcca agacggcccg tccgagcatc gcgaacctcg
     7861 cgcagcagca gtacccgatc accgtcgcgc ccggctcgac gaggctcacc gtcacgatcg
     7921 gcaaccccgc cgaccaaggc gccgacctcg acctgctggt ctacaactgc acgtcgggca
     7981 gctgcgtgct cgccggtcag tcggcggacg cggactccga ggagtccgtg accatcacca
     8041 acccggccgc gggcaactgg gtcgcactgg tggacggcta cgcggtgccc gcgggcacca
     8101 cggagtacga ctacttcgac gtattcacct cggccggtct cggcacgctc accgtgaccg
     8161 acaccaacgc cgaccgcgcc gccggtgcga cgtggaacgc gacgggcgtc atcacgccgc
     8221 tgggccagcc cggtgccggc cgcgtgctgc gcggtgagct cgaggtccgc acggccgaca
     8281 acaccgtcgt cggtaccggc gcggtgatcg tccaggcggt cagctagcag tccggtagta
     8341 cgtagaaagc cccaggaccc acgacgtcct ggggctttct acggttctgg cagcctgttg
     8401 ttcaggggct cgtccaagtc caccttggac acacccgtga tcagatatgc gtcttccacc
     8461 ctgtcgaccg gcatctcggc gcgcaggtag ccgattctgg gatcccgcga ctcgacggtc
     8521 gcgcccagca ccaccagtgc ccgctcgacc tcctcgtcgc gtcccggctg cacggagatc
     8581 atgagtggca ctgtgaggtg gccgtcgcgc ttcgcctgct cgatccggtt cctgtccggt
     8641 ttcgccgatg acacgacggg gacctccgcg ttgggcacgg ctggggaccc gttcgtacca
     8701 cagctaccga gagccagcgc gcaaaacgcg acggcgagcg gtcttctcat ggtgggagga
     8761 cggagcgggc cgcgcgggcg gttgcaccga ctttccccgc gccctactgc ttgggccccg
     8821 caaacgcttg ctcgcgcagt gcgccgtcga cgctctcccc gaacacccgc gcgtccgtgt
     8881 gctggtcaga ggtcggttgc gccttcttga cgccggtgac cgccttcgtg cggatctgcg
     8941 gcaacgcacc ggcatgctgg cggtgcaccc agtccaccag gtgctcgcgc gtcaggcacc
     9001 gcaggtccca caacttgccg gcgtcggccg cgctcacgag cgcacgcacc cgcacgaacc
     9061 cctgcgtcgc ctgagtcacc tgcaacacgg acacccgccc gtcccacagg tcgctgccct
     9121 ccaacatgga ccgcatctcc tgtcgcatcg cctcgaccgg caccgtccag tcgagatcga
     9181 gctcgacggt cccgagcaac gccgactgcg tgcgagtcca gttctcgaac ggcgtcttca
     9241 ggaagtacga cgtcggcagc accagccgcc ggtcgtccca caggtgcagc accacgtacg
     9301 tcagcgtgat gtcctcgacc cgcccccact caccttcgac gacgaccacg tcgtcgagcc
     9361 gcaccgcgtc gctgaacgcg atctgcagcc ccgagatcag gttgcccagc aacgactgcg
     9421 ccgagaacgc cgccaccgcg ccgatcaccg cggccgacgc cagcaccgtc gacccgaccg
     9481 cccgcgcacc ggggaaggtc atcaggatcg cgcccaccgc cagcacgccg atgaccacca
     9541 ggaccagtcg ccgcaccagc gtgacctgcg tgtggacccg ccgcgcgtgc cggttgtccg
     9601 tgacgtccgt gcggatccgc gacagcgata tgtccaccag ggtgctgatc agcgccgaca
     9661 gcagccacgc cccggcgagg atcagcgcga tgcccagcac gtgcagcacg accggcgcgt
     9721 ccaccgggta cacgctgagg cttatctggg cggccaggag cgctccgaac acctggcccg
     9781 gccggtacat cctcccgctg tgggtgaagc ggcggaccag tcggtggacc acctccacca
     9841 ccagcagtgc gaaggccacg gagcagccca tgacgacgaa cagcacgttt cctcctcccg
     9901 tgtcgggatc gggtacccga cgtccgaacg ggtgaacacc atgagccaac tcacgacggt
     9961 cggccggagc ggtttgagtc acacagacca gaacatgctt gcgttcgggg tttgagtttg
    10021 taagactcaa accatgacca caacggaggc gctggaactg gtggagcggg ccggctcggc
    10081 cgaagccctg ttcgggccgc gcaccaccga cccggacaag cgcaggcagg cgaagcgcct
    10141 gtaccgcgca ctggcctcgg tcctgcaccc cgacgtggtc ggaccgggcg acaccagggc
    10201 gcacgcggcc tcggcggtcc tgacccgcct gcaccacgag tggacgcaca gcacgaccgt
    10261 cgagctgcgc acgaggaccg gcgtctaccg catcggcgag ccgttcgcgg tcggcagcat
    10321 cgccaacctc tacgagtccg acggtccgca cgtcgtcaag gtggtgcgca acccggcgct
    10381 caacccgttg ctgcacggcg agtggcaggc gctgcgcagg ctcgaacgct tcaccgaccg
    10441 caaccagtgg ctgcgcccct tctacccgcg cctgctcgac acctccggcg aggtggccaa
    10501 gggcagcagg gccttcacgg tcctggaccc gctgaaagac ggcttcgtga cgctgaagga
    10561 cgtgcagaac gcgtacccgc acgggctgga cggccgcgac tacgcgtgga tgcaccgcag
    10621 gctgctcaag gcgttggccg gcgcgcacca gatcgggttg gtccacgggg ccgtcaccgc
    10681 cgagaacgtc ctggtgcacc cggagcagca cggcatcgtg ctggccggct ggtccttcgc
    10741 cgtggaggag ggccagcgac tccttgccac cagcaaggcc atcgcctacc cgcctgaggt
    10801 cgcggcgcag gaaccggtca ccgccgcgac ggacgtccac atggcacacg cgctgatgct
    10861 cgaaacgttg gcgcaaaacg agaagcgcca acggtcgttc gcaaacggct gtatgcagga
    10921 ccggccatcg cgcaggccgg acgcgcaaga cctgctgaac gagtacgacg aactgctcga
    10981 agaactgtac ggaccaaggg ttttccgccc gttcgccctt ccagaaggag aatgaccatg
    11041 ggacacggca agtgggacga caacgcgtac gccgcggcca agaccttccg cgcggccaag
    11101 gggatcgccg acttcggcta caccgcctcg atcaggtcgc agcccgcgtc gagctggaag
    11161 gccgcgccgg cgctggaccc gttcaaggtc gcctaccgcg agtgccgcga ctcgcccgac
    11221 cacgccgact cgacaccgat cgccgtgctg ttcgacgtga ccgggtcgat gggcgcggtg
    11281 ccgcggatca tgcagggcaa gctcggcaag ttgcacggac tgttgcagcg caagggatat
    11341 ctcgccgacc cgcagctgat gttcggcggg atcggggacg cggacagcga ccgggtgccg
    11401 ttgcaggtcg gccagttcga gtcggacaac cgcatggacg agcagctgcg cgacatcttc
    11461 ctcgagggca acggcggcgg ccagaagagc gagtcgtacg agctggccgc gtacttcgtc
    11521 gcgcggcacg tcgtcaccga cgcgtggcag aagcgcggcc gcaagggcta cctgttcatc
    11581 atcggtgacg agctgaacaa gccgcggctg gaggcgaagc acatccggcg gatcatcggc
    11641 gacgacgtcc accaggacat cgaccccgtg tcggtctacc gcgagctggc gcgcaagtgg
    11701 aacgtctact tcatcctccc caatcagtcg tcgtacttca acgacgacgc catcggtgag
    11761 cactggcggg cgatcctcgg gcagaacttc ctcaagctcg acgaccccgg cgccgtgtgc
    11821 gagctgatcg ccgcgacgat cggcatggag gagcaggtgg tcgacctcga ccaggccctc
    11881 gtggacctcg ccgagatcgg ctcggtcacc gagagcaagg ccgtcggcaa ggcgctggtc
    11941 gccgtcggtg gcagcaagcg cgcggtcgtg gcggccccgc tcggcatcga cggtcccgac
    12001 gacgtggcgc tgagctgatg aacgaccacg tgatcgtcgt cgggctgggg ttcggcgacg
    12061 agggcaaggg tgccaccgtc gacgcgttgt gcgcggacgg gtcggtgtcg gccgtcgtgc
    12121 ggttcaacgg gggagcgcag gccgcgcaca acgtggtcgt cgacggccgg caccacacct
    12181 tcagccagtt cgggtcgggc acgctcgcgg gcgtgccgac ctggctgtcg cggttcgtgc
    12241 tggtcgagcc gatcgcgctg gcgaccgagt cgcgcgagct ggaggccgtc ggcgtcacgg
    12301 acccgctgtc gttgatgtcg atcgacgccc aggcgctgct cacgacaccg ttccacgtcg
    12361 ccgccaaccg ggccagggag agggccaggg gcgacgaccg gcacgggtcg tgcggcaagg
    12421 ggatcggcga gacggtctgg tacggcctgc tcgccggggc ggccgagggg gacgtggtgg
    12481 aggggcagcg ggtgctcggc gagccgggcc ccgccccgac cgtgggcgac tgcctgaacc
    12541 cgatcacgtt gcggcgcaag ctcgacgcgc tcgcccggtt ctacgagccg ttgatcggcg
    12601 aaggcccggg catcggcgaa ctggtcgggc tctaccgcgc gttcgccgac gccgtgcgga
    12661 tcaccgcggg ccacgaaggg ctgctcgacg cgggccgagt cgtcttcgag ggcgcccagg
    12721 gcgttctcct ggacgagacg tacggcttcc acccgcacac cacgtggtcg acggtcgtgc
    12781 cgcgcaacgc ccgcgagctg ctccagggac gtccggcccg ggtgatcggc gtgaccagga
    12841 cctaccagac gcggcacggc gcgggcccgt tgccgacgga ggaccccgcc gtgctcgcga
    12901 ggttcccgga gcgtcacaac ggcacggggg agttccaggg cgcctggcga gccgggcacc
    12961 tggacgcgaa cctgctccgc tactccgtcg attgctgtgg gggtatcgac ggcctcgcgg
    13021 tgacgcacct ggacgctcag ggcttgaagg tcgccactgg tgattcgctg gaggacctgt
    13081 ccgatcccgt cgcctacctg gaggacctgc tcggcgtgga cgtgctcgtc acgggcacgg
    13141 ggccggccag gtccgactac gaggtgcggg agaatccacc acatgatcga gtcgacgttg
    13201 gtctcggtgg acgtcatagc gctccggttt gacccggacg cgcgcacggt gctcgtgggg
    13261 gtcgcaccgc gcgcactgga gccgttcgcg ggggagctgg cgctgcccgg cgtcctgctg
    13321 ggccgcggcg aacggctgcg cgacgcgacc accagggccg tcacgggcaa gctcggcctc
    13381 gccgaggagt ccgtgacggc gacgggccag ctcgccacgt tcgacgagcc gtcgcgtgac
    13441 ccgcgcggcc ccactctgtc gatcgcgctg tgggccaccg tgacgggccc gtccggggac
    13501 gtggccgtct ggcaccggct cgacgacgtg cccgcgctgg cgttcgacca cgaccggatc
    13561 gtcgccgact gccggccgtt gctcgcggac aagctctggc gcgacgtggc gttcacggcg
    13621 ggcctgctcg gacgcgagtt cacgacggcg caggcgctcg acgtcaccga gtcgctgacc
    13681 ggcgaccggc cctacccggc caacctgggc cgcacgatgg accgcgtgcc gggtctcgaa
    13741 cgcaccaccg agcacgcgtc ggcgttgccc aagggcggcc gtccgccgct ggtctggaag
    13801 tggtctagcg aggcagttcg ggcttgaaca gccagcggtc gagcaggtcg cggtgcccgg
    13861 ccagcgcgat gaagtcctcg gtcgtcacga cgccgtgccg gttgcgcgca caccactccc
    13921 gcagcagcgc gaagaacgag tcgtcgccca tctcgcggcg cagcgcgtgc acggtcaacg
    13981 ccccgcgctt gtagacgcgg tcgtcgaacc actgcgaccg cgtgggccgg ccgatcacga
    14041 tgtcctgcgg caggcgcctc aggaggtccc gcgccgccgc ggcgcacgcg tccgccgacc
    14101 ggccgccgga cgcctcggac cacaaccact ccgaatagct ggcgaaaccc tcgttcagcc
    14161 agatgtgctc ccacgaggcg agcccgaccg agttgccgaa ccactggtgc gccagctcgt
    14221 gcgccaccag ccgttccgac ccgcgccgcc cgtccacgtg gttcgcgccg aacgtcgaca
    14281 gcccttgcgc ctcaacggga acgtcgagcg cgtcgtcggt caccacgacc gcgtacctgg
    14341 cgaacgggta cggcccgaac agcgacgaga acagctctat catcgcgttc tgccggccga
    14401 agtcgtgggc caccaggcgc ttgagccgcg acggtgccca gacgccgggc agcgcctcga
    14461 cgtactgtcc gatctggacg gtcgcgaggt aggtcgccat cggcgcggcc atcgagtacg
    14521 tccaccgggt ggtgctgccg gagaccttgc cgtcgaccag caccccgttg cacaccacgg
    14581 tgtacggcga cggcgcggtg acctccaggt ggtacgaggc cttggacgac ggttcgtcga
    14641 ggcacgggaa ccacgacggc gccccgatgg gctgcgaggc cacgatcgaa ccgtccgtca
    14701 gctcgtccca gccgaggtcg ccccactcgg gcgtcgagat cggcttcggg acgcccgagt
    14761 accggacctc gacggtgaag gcgccgcgca cggcggcgcg gacgttcagc acgccacccg
    14821 cgtgcccgta gcgggccggt ctgccgttga ccagcagctt cgagatccgc agcggtccga
    14881 aggacagcga gaacgacgtc aggggagcag gacaggaagc ctgcagcacc gcgcgccccg
    14941 agaggcgcgc ggagtgcggc ttgtagtcaa gctctagcgc gtaatggtgt acggagaaac
    15001 tcatgtccac gcggagatcg ggttgcccag ccaacgggtt cccgacggta catcctctcc
    15061 gcgcatgacc agcgaggcgg gtccgatcgt cgtgtggtcg ccgacggacg cgccgggcag
    15121 cacgatgccg tgcgggccca aagtggaacc ggcgcccagc tccacccggt ccatgcgcag
    15181 gatccggtcg tggaacaggt gcgtctgcac gacgcagccc cggttcacgg tcgctccggc
    15241 accgagctcc accaggtcgg cctcgggcag ccagtacgac tcgcaccaca cgcctcggcc
    15301 gacggacgcg cccagcgagc gcagccacag gttcatgatc ggcgtgccgc cggagaaccc
    15361 gatcagccac ggcacggcga gcacctcgac gaacgtgtcc gccagctcgt tgcgccacac
    15421 gaacgccgac cacagcgggt actcgcgggt cttgaagcgg cccacgagcg tccacttggc
    15481 gaccacggcg accaggcacg cggccacgcc ggcacccagc agcacgaggc cggaggccca
    15541 gaggccgaac tccttcagcg cgaacagcac gcccacgacg agagcgacgt tcagcatcac
    15601 cggcacgaac cggcacagct cgaccagcgc ccgcgcccac atcaggtgct tcggcgggtc
    15661 gaacgtgcgc gactggtccg agacctcggc ggcgcgcggc agcttcatcg gcggcatgcc
    15721 gaggtacgac gacccggcct tggcccgctt cggcgctgcc gacagcacgc cgacgagccc
    15781 gcccttcggc accgcgcgac cgggcgcggt catgcccgag ttgcccagga acgcccgctt
    15841 gccgacgcgc gcggtggcga tgcgcagcca gccgccgccg agctcgtagg acgcgaccat
    15901 cgtgtcgtcg gccaggaacg cgccgtcgcc cactctggtc atcttcggca gcgcgaccac
    15961 cgtggacgcc tcgacgccgc ggccgacctt catgcccagc aggcgcagcc acacgggcgt
    16021 gaacagcgac gcgtacagcg ggaacagggc cgagcgcgcg ttgttcatca gacgctcggt
    16081 cgtccacgcg gcccacgcca cccggctgtg cacggggtag tacccctcgc gcatgccgat
    16141 gcccagcagg cgcacggcga ccagcacgat cagcgcgtac gagccgaacc agatcgcgga
    16201 ggcgaccggg acgtcccaca gcgccgacgt cagcgtcacg gggcggcgca gcacgtacag
    16261 cagggccgga gcggccgcca gcagcggcag cgcggccagc aggccggacg agaggccgta
    16321 catgaggttc cagaagcgcg agcgctccgg gcggcgcgac gggaacgacc gcgcggcctt
    16381 gccctcgcgg atcgccggga cgcccgccca gcgctggccg gtcggtaccg agccgcgcac
    16441 tccggaaccg ggcgccacct cggccttctt gccgatccgc gcgccgggga acagcgtgct
    16501 gcgcgcaccg acggtcgcgc ccgcgccgat ccggacgcgg ccgatgcgca gcctgtcgcc
    16561 gtcgatccac cagccggaca ggtcgacctc gggctcgacg gcggcgccgc gcccgacctt
    16621 gagcatgccc gtgacgggcg gcaacgagtg caggtcggcg ccttcgccga tcttcgcgcc
    16681 cagcgcccgc gcgtagtgcg tgacccagga accggaaagc tcggtggcgc gggacatctg
    16741 cgccagcatc tcggccgtcc acagtcgcaa gtggacggaa ccgccgcgcg ggtacgtgcc
    16801 cggcttcacg ccgcgcagca gcaaccgcgc gccgcccgcg gagatcgcga gacgtccggc
    16861 ggggctgagg aacaccacga acccggccgc gacccaccac cacgacaccg acgtccagcc
    16921 cagcacgttc gacaacgccg tcagcgccac gacccagcgc gcaccggcga tcgtgagcag
    16981 cgggaccatc agcagcgtct ggacgacacc ggtccagcgc ggcgtcggcg cgacctcgcg
    17041 cacctcggcc gtctcgccgt acgactccag cttgcgcgcg agcttgtaga gcgtggggtt
    17101 ctgatagatg tcctgcaccg acgtgctcgg gtagcgcgtg cggatcatcg acacgagctg
    17161 cgcggcaccg agcgaactgc cgccggacgc gaagaagttc gcgtcctcgg aggcagggcc
    17221 ggagccgagc acctcggccc accgctccgc gagccagccc tcgagcccgc tgaacaccac
    17281 accggcggtg tccatcgact cgagcggcca cggcagggcg gcgcggtcga ccttgccgga
    17341 cgtgcgcgtc ggcagcgtct cgaccaccgc gatcaagggg acgagggcgg ccggcagttc
    17401 ggtgcgcagc tgctcgacgg ccgcgtcctg gtcgaactcg ccgtccgtga cgacgtagcc
    17461 gacgaggatc tggttgccgc cgcgagtcgt gcgcacggcc gcggcggctc cggcgacacc
    17521 gggcagcgcg ccgagcgccg cgtcgacctc gccgagctcg atgcggcggc caccgagctt
    17581 gatctgctcg tccgcgcggc cgaggaagac gaggccttcc ggctcggcgc gaaccacgtc
    17641 accgctgcgg tacgcgcggt cccagcccat cgagggcagc ggcgcgtact tctgcgcgtc
    17701 cttctcggcg tccaggtagc gcgccaggcc gacgccgccg atgaccagtt cgccggactc
    17761 gcccatgggc acgacctcgc cctgggcgtc cacgacgacg aggtcccagc cgtcgagcgg
    17821 caggccgatg cgcacggggc cctggccggt catctgcgcg gcgcaggcga cgacggtggc
    17881 ctccgtcggc ccgtaggtgt tccagacctc gcggccgggg acggcgagcc gctcggcgag
    17941 ttcgggaggg caggcctcgc cgccgaagat cagcagccgc acgtcgtcga gtgcctcgac
    18001 gggccacagc gcggccagcg tcggcaccgt ggagacgacg gtgatctcct gctcgaccag
    18061 ccacggaccc aggtccatgc ccgtgcgcac cagcgaccgc ggcgcgggca cgaggcaggc
    18121 gccgtaacgc cacgcgagcc acatctcctc gcaggaggcg tcgaacgcga ccgagagacc
    18181 cgcgagcacg cggtcctcgg gcccgatcgg ctcgtcccgc aggaacagcc gcgcctcggc
    18241 gtcgacgaac gcggcggcgc tgcggtgcgt cacggcgacg cccttgggcc tgccggtcga
    18301 accggacgtg aagatgatcc acgcgtcgtc gtccagcccg ggttccccgg tgacgccgag
    18361 cgtggagccg tgccgcacaa gggatcggcc ctcgcccagc acggcaccca cctgtgcctc
    18421 accgaaaacg agctcggcgc gctcgtccgg atcttcgaag tcgacgggca cgtaggccgc
    18481 gccggccgcg agggtcgcga ggatcgagac gtagaggtcg accgtcccgg acggcacgcg
    18541 gatgccgacc cgatcgccga ccccgacgcc ctcggcggcg agcttgtcct tgagttccag
    18601 tacttccgtg atcagtgcgc ggtacgtcag cgcggtggtg ccgtcgtcga cggccagcgc
    18661 gttcgggtgc gtctcggcac tcgcgcgcag gatgtccagg agggtgcgcg gtgaaggcgc
    18721 ctcgcctgcg gtgaacatcg atgggaggac aacgggttca gccgcgatcg tcacttgtgc
    18781 gtcacttctc accctctcgg caactggtag ccgaccaact ttacagccac gtaacggctt
    18841 acctctcgcc cgagtacgcg ccttcacagg tgacctcagt caccacaaca ctttcgagtg
    18901 acttcttcgc gttgtggcgc gcgaggttcc actcccgcca gtccttctcg ggcgtgcggt
    18961 tcttcagcca ccgcaacgca cacgagcgtt cgtgctcggg aagcctgacg agcgcgggcg
    19021 ccgcgtcctc cgacaactgc gacaggtagt acgtgtcgat cttctgcgtc gcctcgaacc
    19081 gcgacacgtt gtagtcggcg accacccgtt cggggttcat cgccaccaca acgaggaaga
    19141 acgcggcacc cgtagcgacg atcgccttcg gcaaccagtt ggcgcgcaac gagatcccgc
    19201 tcgcgatcac catcacgtac accacggcca gccacacctc gcacgacgcg acgagcagcc
    19261 gcagcaccgt ccacccgtac gcctgctggt agaaccacat gcggctcaag gcactcgcga
    19321 cgatgacgag tgtgagaaca gccagtgaac cgaggagaac ccgcagccac aactggtcct
    19381 tctgcgtctt cttcaccgcg aaccgcgcca caccggcgat cacgccgagc gtcaggatcg
    19441 tgacccacag cagctgccag aacccggacc gcgcgtactc ggcgaacgtc accccggccg
    19501 tcttcatcac gtacgcctcg ccaccgaaca acacggcgag ctgcgtcccc acgaatccgg
    19561 tgaacagcaa cacaagcaca cccacgggca acccgtagtc cttgagccgc aacgaccccg
    19621 gcttctgctc ggcgtcctcg tcgatctccg gcggcgccgc caccagataa caggcgccga
    19681 gcgccccgaa agccgccacc accccgaaga acgcctgctg cacccagtcg tccaggttca
    19741 ggtcaggcac caacgcctcg aggaagtcgt tgaacccctt gtccgccccg gccagcaacg
    19801 acccgaagac caacaacaac accaacgcca caccaacgga gacgaacggc ctgatgccga
    19861 tcggcccgcg cttcttgacc cccttggcga cccacgggat cgaccggaac gcacccagcc
    19921 cgaccccgac cgccccgaac acgagccccc gcaccgtctt gccgccggcc atcgcgatcg
    19981 acccgcagag catcgacgcc agcaggctga gcgggaacac ccactccgcg gcccgcagga
    20041 aggccatcgc gaggaacgcc agggcggccg ccagccacaa cgcccgctcg accgtgggcc
    20101 tgccgctgta gaacagcacc gcgccgacgc cgacgagccc ggccaggaac cagccgatgc
    20161 cgttgttcgg cacggcgagg aaggcaccgg ccaggcctgc ggcgaggccc gcgatcaggg
    20221 ccttgccggg ggcgccggtc gtgggtgggc gccaccaggg catgaacggg acgcccgggg
    20281 cggccatggc gggggtggcg gcggggtagc ggggtgggcc ctgccacggg gagggcgggg
    20341 ggagggtggc ggtgacgacc gcggcgggct ggacggccgg ggtgggctgg gcagcgggtg
    20401 cgggctcggc gacgggcttc gcctcggtgg tgggcttcgc ctgtgccact cgcttgtcgg
    20461 cggtcggctt ggcctctgcc gtgtcaggcg tgtcagccgc gggcttggac tccgcggctg
    20521 cctcgggctg cgcgggctgg ggcttgtccc cggcggtggc ggccccctcc accgtgactt
    20581 ccttcggggc cgtggcgtcc tcgggctcag gcgagcccga ggccaccggc cggtacccca
    20641 ccctccggaa atcccggtac cgcgaccgcc cgaccccctt ccccaccgcc ttccgcgcag
    20701 gcttcccagg cgtcccggac gtctcaccag agtcagtcat gtctctctcc caagcccgaa
    20761 aacgggcgcg cttcaccgcc acaccagcac aaacgggtgc ggacgagaac gaacaagaaa
    20821 agtcagcggg gcaacgtcac ccggatgcac gacccggggt ccaccacggc gatcgtgccg
    20881 ccgtgcagat ccaccaccca ccgggcgatg gcgagcccga gcccggtccc gccaccgccc
    20941 gccctctccc ctcgggtgaa cctctcgaag atccgggacc ggtcggcgac cgcgatcccc
    21001 ggcccctcgt cccggacctc cagcaccacg cacgacccgg acgcgtaccc ggacacggac
    21061 accaaccccc cggtgggtcc gtgccgggcc gcgttgtcca ccaggttcac gagcacctgg
    21121 tggagccgtt ccccgtcggc gaggacggtc aggtcgcccg ggacgtcgat cgagaacgag
    21181 gcggcgggcg cggccaccgc tgcctccgcc accacatccg ccaccagcga cgacaccgac
    21241 agcgtctccc ggttcaggga cagcaccccg gcgtcgatct tcgacaggtc gagcagttcg
    21301 gtgaccagcc gccccagccg ctcggtctgg gcgagggccg tccgcatcgt cgcggcatcc
    21361 ggcgaggcca ccccgtccac cacgttctcc agcaccgcct gcaacgcgga gatcggagtc
    21421 cgcagctcgt gcgacacgtt cgcgatcagc tcacgccgct gctggtcggc ggcggcgagg
    21481 tcggcggcca tcaccgtgaa cgcctccgcg agctgcccga cctcgtcgga cgacgtggcc
    21541 cgcaccgagc gcgagtagtc cccggaggcc atcgaccgcg ccgcggaggt catctcccgc
    21601 aacggcgagg tcatgccgtg cgcgagcagc tgcgaggtca gcagccccag caccagcgcg
    21661 atcaaagtcg tccggggcgg cagccacccc gtcacgtagc ggaagtacgc gaacgacacg
    21721 cacccggaca ccacgatcac gatgccgagc ttgagcttga tcgaccgcac cgagtccagc
    21781 ggacgcggca gcatgtcgat cagctcgagc acgcgtctca tcgcggtacc tccagcgcgt
    21841 acccgacgcc gtgcacggtc cggatgaggt cggcgccgag cttgcggcgc agcgccttca
    21901 cgtgcgagtc gaccgtccgc gacgacgccc cctcgtgcca cccgcacgcc tccgccagca
    21961 ggcgctcccg tgcctgcacg gcggaggggc gttcggccag gaacaccaga aggtcgtact
    22021 cggtcggcgt caggtgcgcc tcgacgcccg agcgcgacac ccgccgcgac gacaggtcga
    22081 tgagcaggtc gcccagctcc agcgaccgcg acgacaccgc acgggacacg cggcgcagca
    22141 gcacgtgcac acgtgcggcc agttcgcgca tcgagaacgg cttcgtcagg tagtcgtcgg
    22201 cccccacggc gagcccgacc agcaggtcgg tctcgtcccc ccgcgcggta agcatcagca
    22261 cgggcaccga ccgcgacgcc tggatccgcc ggcacacctc gagcccgtcg taccccggca
    22321 gcatcacgtc gagaaccacc aggtcaggcc cgaaggcggc cgccacggcc accccggacg
    22381 gaccgtcgtg cgcgaccgcc acctcgaacc cctccgcccg cagccgcgcg gccacggact
    22441 cggcgatcgt gatgtcgtcc tccacgacga gcaccctgcg ctgacctgtc atggcggcga
    22501 ctttatgggt atgtcgtgga ggacgccggg acaagttgtg aagatcgtgt gcagacctgc
    22561 gaggtaggtt cgcaccatga acgtcctcga agcggtcctg gagaggatca cctacgccaa
    22621 cgaggacaac ggctacaccg tcgccaaggt cgacacgggc cgtggtgacc tggtcacggt
    22681 cgtcggcgcg ctgctcgggg cgcagccggg cgagtccatc cgcatgcgcg gcacgtgggg
    22741 ctcgcacccg cagtacggca agcagttcca cgtcgacgac tacacgacga tcctgcccgc
    22801 gacgatccag ggcatccgcc gctacctcgg gtccggcctg atcaagggca tcgggccggt
    22861 gctcgcggac aagatcgtca cccacttcgg cgtcagcgcc ctcgacgtca tcgagaacga
    22921 acccgagcgc ctgatcgagg tccccaagct cggcccgaag cgcaccaagc tcatcgccga
    22981 cgcgtgggag gagcagaagg ccatcaagga ggtcatggtc ttcctccagg gcgtcggcgt
    23041 ctccacgagc ctcgccgtcc gcgtctacaa gcagtacgcg gacaagtcca tcgacgtcgt
    23101 ccgggacgag ccgtaccggc tggccgcgga cgtctggggc atcggcttca agaccgccga
    23161 cgtcatcgcg aaggccgtcg gcatcccgca cgacagcccg cagcgcgtca aggccggcct
    23221 gcagttcacg ctctccgagg ccaccaccga cgggaactgc tacctgcccg aacaggccct
    23281 catcgcggac gccatcaaga tcctccaggt cgacacgggc ctcgtcatcg actgcctcgc
    23341 ggaactcgtc gaggaggagg gcgtggtccg cgaggagctc ccggacgacg agatcgccat
    23401 ctacctggtc ccgttccacc gcgccgagat ctcgatggcg gcccagctca aacgcctgct
    23461 gcacgccgac accgaccgca tgccgagctt cgccaccgtc gactgggaca aggccttcgc
    23521 ctggctcggc accgacctgg aggaacacca ggccgcggcg gtcaagctgg ccctcacgca
    23581 gaaggtcgcc gtgctcaccg gcggccccgg ctgcggcaag agcttcacgg tccgctcgat
    23641 cgtgcggctc gcccaggcga aacgcgccaa gatcgtcctg gccgccccga ccggacgtgc
    23701 cgcgaagcgc ctcaccgagc tgaccggcca cgaggcccgc acggtccacc gcctgctcga
    23761 actcaagccc ggcggcgacg cggcctacga ccgcgaccac ccgctcgacg ccgacctcgt
    23821 ggtcgtggac gaggcctcga tgctggacct gctgctggcc aacaagctcg tgaaggccgt
    23881 cccgcccggc gcgcacctgc tgctcgtcgg cgacgtcgac cagctgccgt ccgtcggcgc
    23941 gggggaggtg ctgcgggacg tgctggcgca gggcagcccg gtcccgaacg tccggctcac
    24001 gcacatcttc cgccaggccc aggagtccgg cgtcgtcacg aacgcccacc gcatcaacag
    24061 cggcgactac ccgatcgtcc agggcatgcc ggacttcttc ctcttcagca ccgacgaggc
    24121 ggaggaggcg gcgaacctga ccgtcgacgt cgtcgcgaac cgcatcccgc gcaagttccg
    24181 gctcgacccg cgcaaggaca tccaggtcct cgccccgatg caccgcggcc cggcgggtgc
    24241 cggcgcgctc aacaccgtgc tccaggaagc cctcacgccg tcgcgcgaca acctgcccga
    24301 gaagcggttc ggcggcaggg tgttcaagct cggcgacaag gtcacgcaga tccgcaacaa
    24361 ctacgacaag ggcaagaacg gcgtcttcaa cggcacgctg ggcgtcgtca tcgccctcga
    24421 caccgtcgag cagaagctga cggtccgcac cgacgaggac gaagaggtcg actacgagtt
    24481 ctccgagctg gacgagctca gccacgccta cgccatgacc atccaccggt cacagggcag
    24541 cgagtacccg tgcgtggtca tcccgatcac gaccagcgcg tggatgatgc tgcagcgcaa
    24601 cctgctctac accgccgtca cgcgcgcgaa gaagctcgtc gtgctggtcg gcagcaagcg
    24661 ggccatcggc caggccgtgc gcacggtcgg ggcgggccgc cgccacacgg cgctggccca
    24721 ccgcctgagg accgcgcagg cgttctgacg tttcgtcagt ccatgctgcg cacgatggtc
    24781 ggctccagcc cctcgtcgtc gtccgtgaga gaaccgcgcc aggggaagga gatctcagcg
    24841 acaccgtcgt tgtagagatg gtccatggct tgcgctccca cttcttccgg gtctggtgtg
    24901 tgcgaacctc gctgtccgtc gagtcggttt cggcttcact gcgcaataac cgctgcggtg
    24961 ctgacccaaa tggtattgat tttcgtcaca tcgcgccaag tggacccgat cggcgtctca
    25021 aggaccggac ggtaatcatc cggtcggtcg aacggagtgg cggcgatcgg ccgaacggcc
    25081 catcatcgtc gatcatgcgg accgccgtcg ccctgctcgc ctgcctggcc ctcctcctca
    25141 gccccgcagc ggctccggcg gaaggtccac aagcgacaca cttgctgcgc gtccccgcgc
    25201 cgatgggcga tgccgcgcaa cggttgctgg ccctcgggta cgacgtgctg gaacagcgcg
    25261 acggcgacga cctgttcgtg gtcggcgacc cgcggaccgc ggacgagctc cgcgccgacg
    25321 ggttcgcgtc caccgcggag aaggtgatgg ccccgtcgca ccggcagccg cgttccctcg
    25381 cggacacgac ctactacggc ggctaccgca cgatcaccgc gcacctggcc cacctcgacg
    25441 aggtggcgaa ggcgcacccc ggcctcgcga ccgtcgtcga ctacggcgcc tcctggcgca
    25501 agacgcaggg cagcggcggg tacgacctca aagccatctg catcaccagg aaaagtccag
    25561 gtgactgcgc actcacgccc accgcgccga agccgcgcct gttcgtgatg ggccagctgc
    25621 acgccaggga gatcacgaca ggcgacatgg cgtggcgcta cgtcgacgac ctggtcggct
    25681 cgcctgacct caccgcgatg ctgtctgaac tggaggtctg ggtcgtcccg atcgccaacc
    25741 cggacggcgt cgagatcgtc gagtccggcg gtgacacccc cgtcctgcac cgcaagaacg
    25801 ccaacggcac ctgcagctcg ggtccacgcg gcgtcgacct caaccgcaac gccggctcgc
    25861 actggggcga ggtcggctcg tccaggaaca agtgcgccga gacctaccag ggcccgcgcg
    25921 ccgactccga ggtcgaggtg caggcgctgg agtcgttgtg gcgcaagctc taccgcgaca
    25981 cccgcgcgcc cggcgacacg gcggcggcct ccgccgacac gaccggcgcc gtgatctcca
    26041 tgcacagcta cggcgactac gtgctcttcc cgtggggctg gagcacgcag aagacgggca
    26101 acgacgccgc gttgcgcaag atggcgaacg acatggccgc gcggtccggg ttcaccgccg
    26161 gccagccggg cgaggtgctc tacaactcgt cgggtgtcac cgacgactgg gtgtacgacg
    26221 acctgggcgt gcccagcttc gtctgggaga tcggtgcgag ctccggccgg tgcggtggct
    26281 tcctgccgcc gttctcgtgc caggcggacg tgcattggcc gaaagtgcgc cccatgctcg
    26341 tttcggccat gaatgcagca aagcgcccgt actgacgcgt tgtgggggca tggggaaacg
    26401 cttgctcgcc accgtcgccg ccttcagcct gctcttcacc gggaccgcgg tcgccgacga
    26461 caccggagtc gaccgcggga ccgtccagga aggcctcgac gaactggtcg cggtcggggt
    26521 cgcccagggc acccaggccc ggatcaccga cggccggacc cgcttcaccg cggtccggca
    26581 ccgccgagag gaacgacccg cgcccggtcc cgctgaacgg ccgcttccgc gcggggagca
    26641 tcaccaagtc cttcacctcg accaccgtgc tgcacctggc cggcgagggg aggatctcgc
    26701 tggacgcgcc cgtcgaccgc tacctgcccg gcctggtcga ccgccggatc accgtccgcc
    26761 acctgctcca gatgaccggg gggctctaca actacaccga cgcgctcgcg ttcgaccccc
    26821 agggcttcga ggagatccgc taccggcagt ggcagccgcg ggagctcgtc gagatctcca
    26881 cgagcaggcc gctcgacttc gaacccggca cgaagtggaa ctactccaac accaactacg
    26941 tcgtcctcgg cctgctcatc gagcaggtga cgcgccggcc gtacgagagg gtcgtcgagc
    27001 agcgcatcct gaagccgttg cgcctcaacg acaccacgtt cccgggcggc gacacggaga
    27061 tccgcggccc gcacgcccac tcgtacggca tcgtgaacgg acgcacgatc gacaccaccc
    27121 gctggaaccc gtccgtcttc tgggccgctg gtgacgtcat cacgaccacc cgcgacctcg
    27181 acaccttcta caccgccctg ctcaccggca agctgctcga gcccgcccag cagagcgaac
    27241 tcacgaagac caccgccgtc agcacggact acggcctggg cgtcttcgtg gagaaggccc
    27301 cgtgcggcac cacgatcatc ggccaccccg gtggcgtgcc gggcttctcg acctacgcct
    27361 actcgacccc ggacctccag cgccgcgtgg agctctccct ctccgcgggc gtcggcaccg
    27421 gcgacccggc gagcgcctac ggcaagctga tcaacgagat cttctgctga tcggaccagg
    27481 ggtcatcccc ccggtgcctg ccgtcttccc ggcaagaccc ctagggacag cgtgcgactc
    27541 caggtggatg cggagccgtg ccccgcctcg atttgctgtg gggcatgggg attcgattgg
    27601 cagcaacagc aacagcaacc gcggcgagcc tgctggtcct gaccaccggg ggcgtcgcgt
    27661 cggccgacac gtcgagcgcg gaccgcgcgg tcgtccagca ggccctggac gagatcacgc
    27721 ggagcggcgc cgcactcggt gtgcaggcga gagtcgtgga cgggcggcag cgcttcaccg
    27781 ccacgtccgg caaggccgac ctgaacagca cccgcccggt gccggacaac ggcaggttcc
    27841 gcgtcggcag catcaccaag acgttcgtgt cgacggtgct gctgcaactg gcgggggagg
    27901 ggaaggtcga cctggacgcg ccggtcgtcc gctacctgcc cggcctggtc gaccagcgga
    27961 tcaccgtccg ccaggtcctg cagcacacga gcgggctctt caactacacc aacgcgttgc
    28021 cgctcagtcc ggaggagttc gagaagatcc gctacaagca ctggacgccg caggagctcc
    28081 tcgcgctctc cacggcccag ccgctcgact tcgaacccgg cacgcagtgg aactactcca
    28141 acaccaacta cgtcgtcgcc ggcctgctgg tcgagaagct caccggcaag ccgtacgaga
    28201 aggccgtcga gcagcggatc ctgaagccgt tgcggctcag ggacaccgag gtgcccggtg
    28261 acgacccgaa catccgcggc ccgcacgccc gcggctactg gaccgtggcg ggcaagccgt
    28321 ccgacatcac ccgcatcaac ccgtcggtcg cctgggccgc cggcgagatg atctccacga
    28381 cccgtgacct cgacacgttc atcaccgcgt tgtcgagggg tgagctgctc aagcccgcgc
    28441 aacaggccga gatgagcagg accacggccg tgagcccgca gtacggcctg ggcctgcagg
    28501 tcgagaccct gccgtgcggc acgaaggtgt ggggccacgg cggcggcatc cccggctact
    28561 cgtcgcagct gctgtcgacg ccggacagca agaagcgctt cgagctcaac gccaccagcg
    28621 gacccaccga gggcaacccg ggagaagcgt tcaacaagct gctcaccgag gtcttctgct
    28681 gattttccgg gaaaacgaaa ggggagctgg gttgacccag ctcccctccc ggcgtttaga
    28741 agaactaccc gagggcgttc ttcatcgcgg tgatcaactc tccgttcgcg gtgtcacccg
    28801 tgagctccca gaagaacgct ccacccagac cctggctgcg ggcccactgg atcttgctgg
    28861 tgatcgtctg cggggtgtcg tagctccacc actggccgtt gcagaacgcg taggccgtgc
    28921 cggcgatggt gccggtggcg gggcacttcg tcttgaggac cttgtagtcc tcgatgccct
    28981 gctcgaacgt gcccggagcc ggaccggtcg ccgtgccacc gggggccgcc tgcgtcacgc
    29041 ccgtccagcc gcggccgtag aagccgatgc cgagcaggag cttgctggcg ggaacgccct
    29101 tcgaacgcag cttcgagatc gcggcctcgg agttgaagcc ggcggtcggg atgccgttgt
    29161 acgacgtcag cggggagtgc ggagccgtcg ggccctgcgc cgcccacgca ccgaagtagt
    29221 cgtacgtcat gacgttgtac cagttgaggt actgcgacgc ggggccgtag tcggcagcgt
    29281 cgatcttgcc gccggcggag ccgtcagccg tgatcgccgc ggtgacgagg aagttctggc
    29341 cgaacttgtt gcgcagcgcc tgagccatgt tcgcgaacgc ggccgggccg ctcgtgtcgc
    29401 aggacaggcc acacgcgttc gggtactccc agtcgatgtc gatgccgtcg aacagaccgg
    29461 cccagcgcgg gtccttcagc aggttgtagc aggagtcgac gaacgcgggc aggttgcgcg
    29521 acgcctcacc gaagccaccg gaccaggtcc agccgccgaa ggagtacagg accttgaggt
    29581 gcgggtactt cttcttcagc ttgagcagct ggttgaagtt gccgcgcacc ggcgcgtccc
    29641 acgtgtcggc gacgccgtcg acgctctccg ccgccgtcat cgacttctcg atggcgggga
    29701 aggtctcgcc gatggtgcac ttgccgccga ccacgttgcc gaacgagtag ttgatgtgcg
    29761 tgagcttcga cgccgaaccc gaggtgtcga tgttcttcac ctggtagttg cgcgccgggt
    29821 agacacccca ctccgcgaag tagcccaggt tgatcttccc cggaggcggg ggcgggccgg
    29881 tcgtcgtcgt ggtggtcgta gtggtggtgg tcgacgtcgt ggtcgacgtc gtcgtggtgg
    29941 tcgtcgggtt cgtcccgccg gcctcacacg aaccaccgtt gagcttgcag ttggtcggcg
    30001 caccgaacgt gccggagtag gcgccgttga agccgaagct caccgacccg cccacgccga
    30061 tgttgccgtt ccaggtgttc ttgaccgtga cggtctggcc gctcgtcgtg tacgagccgt
    30121 cccacagcga cgtgacgcgg tggttggccg gcagcgtgaa ctcgacggtc cacgacgtca
    30181 gggccgccgt gctgttgttc gtgatcgtgt acttgccctc gaagcccgtt ccccagtccg
    30241 aacccttgga gaacgtggcg gaaacgccac cggcaccgct cgcggcgggc acgacgacga
    30301 ttccgaggac catcgcggcg actgccgcga agagagcagc tagatgccat cggaacttgg
    30361 acatcggtct cctcagtcgc agggggtacc ggaacgatgt ggtttagacc actcgaaggt
    30421 caaggtctag acctctgccg tcactcgaat ggagcagttc gaaaacggtt tagtagggct
    30481 cggatgtccg gttccggtct acttggttaa ccattggagg ggttccgaga cgacagccct
    30541 tcgggtcgag ttctggcgcg gtgactgcgc aaagaggacg gtcggcccta acttcgttcc
    30601 atgccaaagc gtttctccac ggcgcgcggc cgcgagttcg gcgacgcggt acgggccgcg
    30661 ctctccgcca cgggcatgac cgcgcgcgag atctgcgaga agatcgactg ggacccggga
    30721 aagctgtccg acctcgtcaa cggcaagggc ggcagctccg aggtcgacct ggccgtgctg
    30781 ctcggcttct gccgcacacc gccggacgag cgcgagcacc tgctgcggat ccaccgccag
    30841 acagacacca aggactggtg gcagaaccac gccgaccagc gcccgttcga aatgcggacc
    30901 ttcctcgaac acctgtggaa ggccaaggag tacgtgtgct ggatgccgct gctggttcca
    30961 ggccttctcc agctccccga gtaccggcgg ccgctgtgca tcgcctccgc caccttcccc
    31021 aaggaccagg tcgaggtgcg cctggccgca cacgcggcga tgcaagaggt cttccgccag
    31081 cgactcgcct gcaccttcta catccacgag caggccctcc tgctgcccat cggtggtgag
    31141 gacgtgttgc gcgcccaact gcaccacctg cttcagatgc tggtgcgtcc gtacatcgaa
    31201 atccgcatcc tccccacatc tgtgggcgcg cacgcaggcc tcagcggggg cttcgagctg
    31261 atgaggttcg acaggttcga gcccgtcgtg ttcctggaga gcgagaacgc gaacttcatc
    31321 atcgagagga aggactccgt cgatgactac gaagaggtgc tgaaggcgct cgatcgagtc
    31381 gcgttggatg cgggagaatc gcagcggagg atctccgaga tcgcgacctg aggagccacc
    31441 atgtggcgta agagcagcta cagcgcaaac ctcaacaact gtgtcgaggt cggtcgtggc
    31501 gtcggcatcc gtgacaccaa ggctcccgcc acccacctcg ccgtcgcccc aggctcgtgg
    31561 tccgcgttcc ttctattcgt gaaggccggc aagttcgcac catcgggtca aaccccctag
    31621 tccgccgcgc gtccccgccc ccgccgcccc aaccatgatc aggtgacgct cctcgccacc
    31681 gtcttcaacc tcgacggcac cctcgtggac agcaccgcga cctggaacca ggtcatcagc
    31741 gccgtagccg cccgccacga ccgctcctgg acccgcgccg actgggccgc tatcgagggc
    31801 aggaccacct ggggcgccta cctcgccgac cggtgcgacg gcctgacgcc ggaacgagcg
    31861 gtctcggagt gcgtcgacgg catggtcgac gcgatcgcgc gcggcacgtt cgggctgcag
    31921 ccgggggctg cggaactggt cgccctcgcg gcggagctgg gaccggtggg cctggtgtcg
    31981 gcggcgccgc gccggtacgt gcgggccgcc gcgtcggcgt ccgggatcct gcggcacgtg
    32041 caggtgatcg tgagcggcga ggacgtccag aacggcaagc ccgcgcccga tccctacctc
    32101 gtggcggcgc gcaagctggg gctggagccc gggcagtgcc tcgcggtcga ggactcggag
    32161 ccgggcgtcc ggtcggcgca cgcggccggg atgaccgtgc tcgcgatcac gagcgcgcac
    32221 accgaggcgg cgcagcacgt tccggacgcc aagctggccg ccaaggcgat gtgccggctg
    32281 tgggtcgacg tctacgcgct caaccgatag cccgctccgc accccacgcg gcgacgtcct
    32341 cgcggctctg caggcccagc ttctcgcgca gccgcagcag tcgcgaggcc acggtgcgca
    32401 cggagacgtt caggcggttc gcgatctgct ggttggtcag gcccgtcgcg agcagcgcga
    32461 tcacgcgccg ttcgtggtcg tccagcgcgt cgaacgcggc ctccgtgcgg tccagccaca
    32521 cctcgtcctg gatgaacgcc tcggtctccg cggcggtcaa cggcgtgctg acggcctccg
    32581 cgcgcgcaac ggggagcatc agccgtgcgg cgcgcatagc ccctgcgacc ttttccgccc
    32641 aaaacgggtt cggcaccaca ccgacagagc ggcgcatcgc ccgtccggtt gcttccagcc
    32701 gtagcgcgcg ctcggcctga ccgcgcatca acgcgaccac ggccaaaccc tccagcgcgt
    32761 cgggcgcggt caacgggttg atgccgtcca tgcgcaacgc ctcctggaac gcgtgcgccg
    32821 actcgtccag gtcgccctgc accaacgcga cggcgccgcg tgtgttcaga gcagaggcga
    32881 tgcgcgcggg gacgcccgac gcgcgggaga tgggcaacgc ggacatgacg ttcgcctcgg
    32941 cgcgttcgtg cttgccgagg aacaaggccg tacgcgctga atcgaccagc acctgcgcac
    33001 gcgcgagggg ctcgcccaac aactcggcga ccctcaagca ctccgtgttg ttcttgtccg
    33061 aggcctccca ctcgcccgaa taccgctgca cggccgctaa cgtgctgcgg cagctcatcg
    33121 ccagtgccgt cgagctcgcg ggcacgagcc gtgacgcctc accggacagt tccacggcct
    33181 cgtcgtggtc gccctgctcg gccgcgaacc gggccgcgtg gttcagggcc acgcaccggt
    33241 agtcgtcgcg cgtggacggc cgccgcagcg cgtcccgcag cagcacgcgc gcctggccga
    33301 gccgtccgcg ccgggcggtg cagtcggcca gcgccgccgt gagcagcagc aggcgttcgt
    33361 cagcgcggtc ggccgcccat tcgaccgtgc cgagcaggct gtcgacgtgg tcgtcgagtt
    33421 tgcgctgcac gtccgcgggc atcgacagcg gcgtggtgag cagcgcgtcc gacaggtcgg
    33481 tgaaccagcg ggccagcgcc tcgtaggcgg tgtcgagctc gcccgccgcc agcagcttct
    33541 ccctggcgtg caaccggatc gtctccagct gccggaaccg ggtcgtgccg ggtacggccg
    33601 tcatcaacga cttcgcctgc agccgggaca gcacgtccag cacgggttcc accgagcgtt
    33661 ccgacgtgca gacctcgttg gccgccgcca ggtcgaagcc gccgtcgaac accgacagcc
    33721 gccgcagcgc gaactgct
//
