LOCUS       NZ_CP099738            22037 bp    DNA     circular CON 27-AUG-2024
DEFINITION  Lentzea sp. HUAS12 chromosome.
ACCESSION   NZ_CP099738
VERSION     NZ_CP099738.1
KEYWORDS    RefSeq.
SOURCE      Lentzea sp. HUAS12
  ORGANISM  Lentzea sp. HUAS12
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 9676923)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024125735.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 06:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,161
            CDSs (total)                      :: 9,080
            Genes (coding)                    :: 8,988
            CDSs (with protein)               :: 8,988
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 21 of 92
            Pseudo Genes (incomplete)         :: 77 of 92
            Pseudo Genes (internal stop)      :: 3 of 92
            Pseudo Genes (multiple problems)  :: 8 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:47:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6185739
            Orig. end                         :: 6207776
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099738.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ping Mo.
FEATURES             Location/Qualifiers
     region          1..22037
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="30"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22037
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22037
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12037](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12037
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            780..1652
                     /locus_tag="ND450_RS28145"
                     /old_locus_tag="ND450_28145"
     CDS             780..1652
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944149.1"
                     /locus_tag="ND450_RS28145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28145"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_253321564.1"
                     /transl_table=11
                     /translation="MIGLRTLRAVAMTAATLGGLSGALVGLLTEQGRRARVAIGVLEHL
                     WPAPDGVYLDDGGDPVRLAVLGDSMAVGVGVTHPSQMPGVLLAEALAEEAGRPVRLSTY
                     AVSGSTTRDLVPQVDAAVRDAPQVALIIIGANDVTSRMGTGESARLLAEQVRRLRAVGC
                     GVVVGTCPDLGTVRPIAQPLRAIGHRYSVRLAAAQTVAVRRAGGVPVSLGNLLAPEFMA
                     RHTDMFSSDRFHPSAAGYEAAAGVLLAPLCQVAGLWAGWTGPSTPIRSAAALAMRPSRV
                     PAWLQKRHV"
     gene            1744..2964
                     /locus_tag="ND450_RS28150"
                     /old_locus_tag="ND450_28150"
     CDS             1744..2964
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466189.1"
                     /locus_tag="ND450_RS28150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28150"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_253321565.1"
                     /transl_table=11
                     /translation="MPEAVIVSAARSPIGRAGKGSLKDVRPDDLVARMIRAALDKVPQL
                     DPAQIDDLMLGCGLPGGEQGFNMARVVSVLLGYDNLPGTTVTRYCASSLQTTRMALHAI
                     KAGEGDVFISAGVETVSRFAKGSSDSWPDTHNPLFAEAEARTAATKAAGAEEWVDPRTL
                     DVVPDVYIPMGETAENLALLKGISRQEMDEFGVRSQNLAEKAIADGFWAREITPVELPD
                     GTVVSADDGPRAGVTYEAVSQLKPVFRPNGRINAGNCCPLNDGAAALVIMSDTKARELG
                     LTPLARIVSTGVSGLSPEIMGLGPVEASKRALALAGLSVSDIDLVEINEAFAAQVIPSY
                     QDLGIDLDRLNVNGGAIAVGHPFGMTGARITTTLINSLQFHDKQFGLETMCVGGGQGMA
                     MVIERLS"
     gene            3126..3335
                     /locus_tag="ND450_RS28155"
                     /old_locus_tag="ND450_28155"
     CDS             3126..3335
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS28155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_28155"
                     /product="hypothetical protein"
                     /protein_id="WP_143091438.1"
                     /transl_table=11
                     /translation="MPYVWWQSEYDLQCHAFSLDQADGSRSFYEAVCEHSVPDERVSRA
                     QAGALCTDCLIKVGSDLPDVRWRV"
     misc_feature    3160..3170
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(3332..3742)
                     /locus_tag="ND450_RS28160"
                     /old_locus_tag="ND450_28160"
     CDS             complement(3332..3742)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336503.1"
                     /locus_tag="ND450_RS28160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28160"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_253321566.1"
                     /transl_table=11
                     /translation="MDTAYRLVLEPPSLDDYQRLRKESGLSERPREEAEKGLTGAWASA
                     SVIHVESGETAGMGRVVGDGGTYFVVIDMAVLPEHQRKGLGDAILTALLAKIHETAPGA
                     LVSLLADPPGRRLYARHGFVESAPDSVGMWRR"
     misc_feature    3880..3894
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(4035..4841)
                     /locus_tag="ND450_RS28165"
                     /old_locus_tag="ND450_28165"
     CDS             complement(4035..4841)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005155843.1"
                     /locus_tag="ND450_RS28165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28165"
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="WP_253321567.1"
                     /transl_table=11
                     /translation="MRSSSNPAFRNLPTGGGYGGYAGFGQPEQAGYQQAPPPLTSERPM
                     TIDDVVTKTGITLAVVAATAVVTYLMQAWFLLFPAAIIGLVLALIITFKRMPSPPLVIA
                     YAAVEGIFLGAFSGIIGNMIDGMTNKPGQGVVVIGQAIIGTIGVFAGMLVVYKTGAVRV
                     TPKFTKWIVGALIGVGVLMLFNLIMSFFTDGGLGLRNGGPLAIIFSLVCIGLAAFSFLI
                     DFDAADQAIRAGVPAKFAWQIAFGLTVTLVWLYTEILRLLSYFNSD"
     misc_feature    5021..5036
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.05"
                     /tool="antismash"
     gene            5160..6548
                     /locus_tag="ND450_RS28170"
                     /old_locus_tag="ND450_28170"
     CDS             5160..6548
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098213.1"
                     /locus_tag="ND450_RS28170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28170"
                     /product="collagen binding domain-containing protein"
                     /protein_id="WP_253321568.1"
                     /transl_table=11
                     /translation="MGWKRLAAVAMVSGLALLTVPATATAVGVKGIGHNASGLQPNATP
                     GSEWHGSYIWQDKQVWCVQYALPAPDSTVGYKEGDALRTKAGKDLAPDIAANISYLLLR
                     YSTTKSPDEAAALAHLLHSWTSAPDGEVTYDTTDAKRLAYNAEFYAARLPQSVMDTVAR
                     IKADAEANRGPWTLTATAPKEPLVIDAESSWTLSLVKANDKGVTNAPIAFTLTDAKLAD
                     GATSGTATTGADGSPAVVKLIATGPKPSIAAVADSPADRPVVHFPIQTENMQRMVTTGG
                     EKKLNAAANTTAKTAPGAVKITKIDSETKKSIAGVALRVTAKDQTSAAKKQDDTDLVGT
                     DGKPLVLQTGADGTVEVPDLRTPQEICLVEVAAPKGYEEFFDPKAPPSACGTLAAGQTL
                     ALELVNKPNKPVLPSTIPAGADGQTPVATASFDTQLRPGLMLAVGGLVLFGAALAGFLV
                     WRRQ"
     gene            6533..7243
                     /locus_tag="ND450_RS28175"
                     /old_locus_tag="ND450_28175"
     CDS             6533..7243
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641276.1"
                     /locus_tag="ND450_RS28175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28175"
                     /product="class F sortase"
                     /protein_id="WP_253321569.1"
                     /transl_table=11
                     /translation="MAEAVSGRAFLTGALVAGVAAASVLVGTSETAVVKGRAVADEIPV
                     VAPGPVADSLSTGRGPDLTGLVGGANTANAKPAEPAPQQQQPAPPKAGPGSVRLPAGGS
                     ATLVRKEVKDGVLPVPDGIGEATWWGTEISGAEGATVLAGHVDWKGAKGPFAELWQAQN
                     GREVVIADSAGKEFRFRIKQIETVRKEELPARAVEFFGPRGPHRLVLVTCGGTWIGGQQ
                     GYEANRVVIAEPVQ"
     gene            7314..8462
                     /locus_tag="ND450_RS28180"
                     /old_locus_tag="ND450_28180"
     CDS             7314..8462
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098211.1"
                     /locus_tag="ND450_RS28180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28180"
                     /product="polysaccharide deacetylase"
                     /protein_id="WP_253321570.1"
                     /transl_table=11
                     /translation="MTTGVALGLVLAMVWTLGSHDEQTPVSDSGPLPMAPRLPAPKDAG
                     PTPTVPAPTPEQLAKQPWMHKLAPGEKPPQFVLFSFDGAVSKQHWDKVLPIAKAKNAHV
                     TGLLSGVYMLADQDKLQYQPPAGLKRGVSDISFGGTRQDITARIGYLNQVIADGHEIGT
                     HYNGHFCSGGTQPSVDKWDTAAWNQELDQFKQLVDSSRAAGLNLPADAVRGGRTPCLEG
                     NWDQAFPAMAAHGLVYDTSKVALGVQWPTVQNGLYEFPMPEVRVPALGKQVVMMDFNLW
                     YSLNKAQDEPHRAADFAQIVLDTYKSVHQAALNGNRAPIVVGNHFNEWNGNAFSTAMEQ
                     FMEYVCDKPETVCATYTEVIQWMQLQDPAVLDQLRRMPAARN"
     gene            complement(8478..9512)
                     /locus_tag="ND450_RS28185"
                     /old_locus_tag="ND450_28185"
     CDS             complement(8478..9512)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098210.1"
                     /locus_tag="ND450_RS28185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28185"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_253321571.1"
                     /transl_table=11
                     /translation="MRARRIAAAAACTALAATLCAVPASAQDYPSVLAERTLATKLDIP
                     WDIEFLPDGSGIFTERDTRKIKKISGTTVTELDTVEQAQTTGGEGGLLGLAVSKSFATD
                     NSVFIYYSTASDNRVAKLQLGGTPQPIVTGIPKNRYHNGGGLEWGPDGFLWATTGDGQN
                     TANAQNWNSLGGKVLRFDTAGQPAAGNPRAGSVVYSIGHRNVQGITWIGSTAYATEFGN
                     NTTDEVNRIEAGKNYGWPTCEGNCNVSGMTNPVKTWSTSQAGPTGIAFYKNALYVGAVT
                     GKRVWKIPVSGTTLGTPQAVFTGYGRVRAVTTAPDGTLWLGTSNQDANGSPGANDDRII
                     STDG"
     misc_feature    complement(9747..9758)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.83"
                     /tool="antismash"
     gene            9801..9923
                     /gene="pqqA"
                     /locus_tag="ND450_RS28190"
                     /old_locus_tag="ND450_28190"
     CDS             9801..9923
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005464294.1"
                     /locus_tag="ND450_RS28190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28190"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_063758378.1"
                     /transl_table=11
                     /translation="MNVAVTTTETKLPEVRREWVKPDFRDFETPMEVTAYAARS"
     gene            10001..10696
                     /gene="pqqC"
                     /locus_tag="ND450_RS28195"
                     /old_locus_tag="ND450_28195"
     CDS             10001..10696
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336983.1"
                     /locus_tag="ND450_RS28195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28195"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_089909443.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.6e-81, bitscore:
                     272.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVPPAEFVAELRALAPRYWDSHPFHLRMHAGQLGKHELQAWAA
                     NRWYYQRCIAQKDAAILSNCPLPEIRRQWRERIVWHDGTKPGEGGAENWIRLAEAVGLT
                     RDEVLDERHVLPGTRFAVDAYVNFARTKPWVEAIASGLTEMFSGALMRKRLTALREQYP
                     WIAEEGFAYFTNRIEAVAGEGRATVDIVVEHSRTREQQLAAVAALSFKCDVLRAVLDAV
                     DYYSGRGRP"
     gene            10693..10965
                     /gene="pqqD"
                     /locus_tag="ND450_RS28200"
                     /old_locus_tag="ND450_28200"
     CDS             10693..10965
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098207.1"
                     /locus_tag="ND450_RS28200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28200"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_253321572.1"
                     /sec_met_domain="PqqD_RRE (E-value: 6.6e-19, bitscore:
                     66.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.7e-10, bitscore: 39.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVALDAVPRIRRGVKCTYDQIREAHVVLFPEGVLVLNETAASVV
                     ALCDGVRSIGDIAVALADEYAGVEPGDVVSLVVRMVERRVVDVDG"
     aSDomain        10696..10953
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_ND450_RS28200_PqqD_RRE.1"
                     /evalue="2.00E-21"
                     /identifier="RREFam006.1"
                     /label="ND450_RS28200"
                     /locus_tag="ND450_RS28200"
                     /protein_end="87"
                     /protein_start="1"
                     /score="66.5"
                     /tool="antismash"
                     /translation="TVALDAVPRIRRGVKCTYDQIREAHVVLFPEGVLVLNETAASVVA
                     LCDGVRSIGDIAVALADEYAGVEPGDVVSLVVRMVERRVVD"
     gene            10958..12037
                     /gene="pqqE"
                     /locus_tag="ND450_RS28205"
                     /old_locus_tag="ND450_28205"
     CDS             10958..12037
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150538.1"
                     /locus_tag="ND450_RS28205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28205"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_253321573.1"
                     /sec_met_domain="PTHR43273 (E-value: 3.1e-31, bitscore:
                     107.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.1e-21, bitscore: 76.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.9e-12, bitscore: 45.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.6e-11, bitscore:
                     43.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEAPFGLLAELTHRCPLQCGYCSNPLELVRRDAELSTEDWRRVF
                     DQARALGALQIHLSGGEPLLRPDLPELVAHANSLGCYVNLVTSGVGLSRDRLRTLASLG
                     VDHVQLSLQDATRAGNDRIAGIKAFDRKVEAASHVLDEGLPLTVNTVLHRQNLDNVAGI
                     IAMAERMGAERLELANTQYYGWALRNRAVLLPTREQLAAADPVVAAAQERLRGRMEIVY
                     VIADYHEAHPKPCMYGWGARQLTVAPNGDVLPCPAATVISSLEIENVRDSSLHDIWHHS
                     PSFNAFRGFEWMKDPCRSCPRKEVDFGGCRCQAFQLTGDAAATDPVCSLSPDRSTVDLI
                     LETEMAPAEVPAMAMRKMR"
     gene            12034..12909
                     /gene="pqqB"
                     /locus_tag="ND450_RS28210"
                     /old_locus_tag="ND450_28210"
     CDS             12034..12909
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="ND450_RS28210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28210"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_253321574.1"
                     /transl_table=11
                     /translation="MKAVLLGTTAGGGFPQWNCACSLCVRARSGALPSRSQDCLAISGD
                     GADWWLVNASPDIRTQITSCSFLDPGPGARETPLRGALFTDAELDHTLGLLTLRGGKGV
                     TVWAPAPVLRALKDEFDLRTVIDGYAPVAWREAAGSFDLGGLRVTAIPISGKRPKYARS
                     STVDGDWVVAYRFEDPVSGGVLVYAPCLAAWPDGFDEVVAGADCLLLDGTFHAASEMGS
                     ATGSASGQAAMGHLPITASLPELRRFPGVRRLYTHLNNTNPVLDPSSPEAVELHEAGVE
                     VPLDGTVIEL"
     gene            12928..14076
                     /locus_tag="ND450_RS28215"
                     /old_locus_tag="ND450_28215"
     CDS             12928..14076
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333559.1"
                     /locus_tag="ND450_RS28215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28215"
                     /product="CdaR family transcriptional regulator"
                     /protein_id="WP_253321575.1"
                     /transl_table=11
                     /translation="MSYVIGGRPLAARLVAEMPSFVRQVIEALVERVPAYSQLPAEELA
                     GDIHRVTEHALRAFAQVLSTGELPSAAELAFLRESAARRAEEGVPIDVVLTAYHVGIQV
                     VWDVLVPEARPEEVQDVLALNALALRYLQLVTPVVSAGYLDERQTMFDDERSARATLLT
                     GLLAGTVEAPGPFVVFALHLPPHPDELLPGVDAAVASRRKLRRVRTELERHSREPVLSS
                     LTSDGGLALLPGEDLPCERIVADVTRAAGVPVTVAAVAAGASGVAAAAVLAREVLAVAV
                     RSGPGLYRLTDVLLEYQLSRPSAALEPLAAIVEPLTDELVQTLEVYLRRGSRRPAATEL
                     HVHPNTVDYRLRRVAELTGLDPTRIEHVTLLTAALAARRSRP"
     gene            complement(14030..14872)
                     /locus_tag="ND450_RS28220"
                     /old_locus_tag="ND450_28220"
     CDS             complement(14030..14872)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228716.1"
                     /locus_tag="ND450_RS28220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28220"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_253321576.1"
                     /transl_table=11
                     /translation="MRIVAGLAVVAMLVAGTSTAQADTLDYVALGDSAAAGPLIPNPDP
                     ALWCLRSDRNYPQVAAKLLGARLTDVTCSGAKTDDFAGRQFGFVAPQYDALKPTTDLVS
                     ITIGGNDVGLVQTALGCINLLPEPVGLSCEARLTAGGDQVAAAIRGWAPEFGAALDEVK
                     RRAPHAKVLVTGYGTYIRPGGCYPVQPIWGRDADFLQRSVDLLSATAKAEAEKRGATYV
                     DLAAVSVGHDTCAKPADRYLEGLVPTTVAAPLHPNAAGMAAFGATVANAVRPAQPSKA"
     gene            14989..15729
                     /locus_tag="ND450_RS28225"
                     /old_locus_tag="ND450_28225"
     CDS             14989..15729
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012673.5"
                     /locus_tag="ND450_RS28225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28225"
                     /product="inositol monophosphatase family protein"
                     /protein_id="WP_253321577.1"
                     /transl_table=11
                     /translation="MTPADLLSLATQSCVDAAKLLREIRVDVSAKGAYDQVSTADLELE
                     AFLRACLTEGAPGSAVVGEELGSASAEVTWFVDPIDGTRNFVRGLPLSCISVAAAVDGV
                     LVAGCVLDPFRDELFTAAAGVPFGVRSTGLVIPPGVSPRPLVLTDIPLPGSPYEGEVEF
                     LADLMERADVRRVYSTALSLAWVAAGRADAVTNIGIHPWDVAAGAVLVREAGGVFTGIG
                     HTAFAAGRGEIVGWLADRVEGIVS"
     gene            15726..16409
                     /locus_tag="ND450_RS28230"
                     /old_locus_tag="ND450_28230"
     CDS             15726..16409
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (46-147). E-value: 8.8e-08.
                     Score: 24.2. Matches aSDomain:
                     nrpspksdomains_ND450_RS28230_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034196.1"
                     /locus_tag="ND450_RS28230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28230"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_253321578.1"
                     /transl_table=11
                     /translation="MIDLSGKVVLVTGAGGTIGAGIAARFEAAGALVVRHLGREDGDLR
                     TEAERVVGEAAARHGRLDAVVNNAGAQPVDPLPGMTSERWRSVLDTNLTGPFSVTQAAV
                     AHLPAGGSVTHIASIEGTHPAPGHAHYAASKAGLIMHARAAALEYGPRGIRVNTVSPGL
                     IARPGIEEQWPEGVARWREAAPLTRLGTPEDVGDACVFLASDLAKWITGHDLVVDGGVT
                     ARPTW"
     aSDomain        15864..16166
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS28230_PKS_KR.1"
                     /evalue="8.80E-08"
                     /label="ND450_RS28230_PKS_KR.1"
                     /locus_tag="ND450_RS28230"
                     /protein_end="147"
                     /protein_start="46"
                     /score="24.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="EAERVVGEAAARHGRLDAVVNNAGAQPVDPLPGMTSERWRSVLDT
                     NLTGPFSVTQAAVAHLPAGGSVTHIASIEGTHPAPGHAHYAASKAGLIMHARAAAL"
     misc_feature    16440..16455
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            16715..17764
                     /locus_tag="ND450_RS28235"
                     /old_locus_tag="ND450_28235"
     CDS             16715..17764
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS28235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_28235"
                     /product="YncE family protein"
                     /protein_id="WP_253321579.1"
                     /transl_table=11
                     /translation="MTSEYRPISRRTLLTAALGGAAVGVVGQGLFAGAAGAAPKAGRQK
                     LLIGSVDRLGNGVVQLTDPSLTGEQTLVPVNGQPNGIVGSPDGLRAYVGTVFGPGLSVV
                     DVDGGRVTGEVAVGGFANELLVSPDGRTVYVATGSAGAGGSSGHVAVVDTASGEVRARI
                     KAGLLPRSLALSPDGKQLFVGDERAKGVTIVDTAKNAVSGRFETDGTPLLIAIDPKGKN
                     LYVAQSRELATFGLRGGKSGATALDGVPCGLAVHPNGTFAAVSLYAGRNSDSQLVTVNI
                     NSNKVRTKESNGKANGPLAMSKDGGRAFVLDEKNRKVTSADTNSGKPDSSLPTPNSNTP
                     TSVAFVETA"
     gene            17784..19151
                     /locus_tag="ND450_RS28240"
                     /old_locus_tag="ND450_28240"
     CDS             17784..19151
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS28240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_28240"
                     /product="hypothetical protein"
                     /protein_id="WP_253321580.1"
                     /transl_table=11
                     /translation="MPISMSVKTLDYTPTWPPYPSLWMGGYGGAPRGNQGAVDRRLRAQ
                     CIVIDDGAGPKVMLRIDVVSIPRYVHQSIRSQVLPLVNNENGNFLIICSHTHSGPFIGT
                     TRPHPYVMMSLTPADISAIEDTTNVFISQMVTLVQQTLAMARTQVTLWYKEGNASIGYN
                     RAGEPNVLTTVNALIARRTSDNALQTVLFGYACHAVARGNDKTFCSDFPGAATDVISNA
                     LGVQALFFQGAAGDQEPNDPHSPSQVTNLGTILGNAVVSMVNSGGWTAVTAPITTYYQE
                     LSLPFTVDFGDPAAVIRARNSYNARLDNLAPGDYAYRHAEVMLEQIAGPGLPRVFPMPI
                     QRWKLGGLNIFAMSHEVLSEYAVNLRNQIPGNLWVMAYANETEGYVAANGILQDGGAVR
                     WGYEAGWVDDPEISGEATWTTFYPWPAPLKFSPSGPAAPGTTERIVMDASTAMLNL"
     gene            19168..20028
                     /locus_tag="ND450_RS28245"
                     /old_locus_tag="ND450_28245"
     CDS             19168..20028
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025870.5"
                     /locus_tag="ND450_RS28245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28245"
                     /product="tachylectin-related carbohydrate-binding protein"
                     /protein_id="WP_253321581.1"
                     /transl_table=11
                     /translation="MPGPSTTLSSRYGLAPVYPCGTTGNLFLFEHSTPATGTFAWGQSY
                     QIGAGWQGRVIAGPSGWMFSITTGGELRVLHYNGTGWDLLNGSQYLVLGQGWNYTAANT
                     RNRITVDEDGVIYTLDAAGNLKAHYFNFTTQQWAVQGALLETGLTQYNAIVATSRGVIY
                     ARNAGGAMYRYYIDFWSGATATWVKPVSTVTTGWQNLKHLSSAGGETFYAVNQNNGNLL
                     WYSYNPVTKVWKNAKIIGSGWNSEQDVVVQSNICSRFPWETACNSFGMQDGGAVITRLN
                     QVKKN"
     gene            complement(20083..21171)
                     /locus_tag="ND450_RS28250"
                     /old_locus_tag="ND450_28250"
     CDS             complement(20083..21171)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023524.5"
                     /locus_tag="ND450_RS28250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_28250"
                     /product="MrcB family domain-containing protein"
                     /protein_id="WP_253321582.1"
                     /transl_table=11
                     /translation="MRELLRDVMVLQAEWTSESTSEMQERGRLIRHDISNWLRERLPDL
                     RRAAPVEITDWRVGSSDGAGNRAEIPWARVHSSSRSPSATKGWYVVYLFAAPGDRVYLS
                     LMQAASRKKNREYKGLPGSGLRQRAHEMREALSASLRARPDLVDAIELKATRSELGRAY
                     EDGTVVAFEYPLRDLPSDEVLADDLTFLVSVLSELYELLDHGTTAPEIADAEVEAERSA
                     GKARSGQGLRQSAPERIAIERRAVAVATEYLEEQGYDVEDVGTKESYDLDARRADERVY
                     VEVKGTTTTWTDASEIILTRKEVELHLREYPNNMLLVVSGIVLDRSVSPPEASGGTLRV
                     IRPWAVKEPNLTPVSYRYLVGE"
     misc_feature    complement(21300..21315)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    21619..21633
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.13"
                     /tool="antismash"
     misc_feature    complement(21643..21657)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.73"
                     /tool="antismash"
     misc_feature    complement(21645..21658)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.47"
                     /tool="antismash"
     misc_feature    complement(21647..21662)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.21"
                     /tool="antismash"
     misc_feature    21830..21846
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.98"
                     /tool="antismash"
     misc_feature    complement(21832..21847)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
ORIGIN
        1 tacgggcggc cggtgccgcc ggagtagacg gagccctccg ggtcggcgcc gacgaccgtc
       61 acggcgccgt tcgagatctc cttgaggtag cggccggtgc cggagatcgt gccgccggtg
      121 ccgacgccgg cgacgaagtg cgtgatcctg ccttcggtct ggcgccagat ctcggggccg
      181 gtctggtggt agtggctcgc cgggttctcc gggttggagt actggtcggg cttccacgcg
      241 ccggggatct cgcggaccag ccggtcggag acgttgtagt aggagtccgg gtgctcgggc
      301 gcgacggcgg tcgggcacac cacgacctcg gcgccgtagg ccttgaggac gttgcgcttg
      361 tcctcgctga ccttgtccgg gcagacgaac acgcacttgt agcccttgcg ctgggcgacg
      421 agggcgagtc cgacgccggt gttgccggac gtgggctcga cgatcgtgcc gccgggcttg
      481 agctcaccgg agcgctcggc cgcctcgacc atgcgcagcg cgatgcggtc cttcacgctg
      541 ccgccggggt tcaggtactc gaccttcgcc agcaccgtgg ccttgatgcc cgtcgtcagc
      601 gagttgagct tgaccagcgg cgtgttgccg accagatcga cgacgtgttc gacgtactcc
      661 accggtatct actcccctgc tcccactctc cgagatagcg ggacgaagcg tagctctagt
      721 ggctgcggag gttgattcga acagcgcggc cgacgattcc ggggaaggag gtggcgcgga
      781 tgatcgggct gagaacgctg cgcgcggtgg cgatgaccgc cgcgacgctc ggagggctgt
      841 ccggtgcgct ggtcggcctg ctgacggagc agggaagacg tgctcgggtg gccatcggcg
      901 tgctggagca cctgtggccg gcgccggacg gcgtgtacct cgacgacggc ggcgacccgg
      961 tgcggctggc ggtgctcggc gactcgatgg cggtgggggt cggtgtgacc catccctcgc
     1021 agatgccggg cgtgttgctg gcggaggcgc tggcggagga ggcggggcgg ccggtgcgcc
     1081 tgtcgacgta cgccgtgagc gggtcgacca cgcgtgacct ggtgccgcag gtcgacgcgg
     1141 ccgtgcggga cgcgccgcag gtcgcgttga tcatcatcgg cgcgaacgac gtgacgtcgc
     1201 ggatggggac cggcgagtcg gcgcgactgc tggccgagca ggtgcgcagg ctgcgcgcgg
     1261 tcgggtgcgg cgtggtcgtc ggcacgtgcc cggacctcgg gaccgtgcgg ccgatcgcgc
     1321 agccgttgcg ggcgatcggg caccgctaca gcgtgcgtct cgcggccgcg cagacggtcg
     1381 ccgtgcgccg ggcgggtggt gttccggtgt cgctggggaa cctgctggcg ccggagttca
     1441 tggcgcggca caccgacatg ttcagctcgg accggttcca ccccagtgcg gcgggctacg
     1501 aggcggctgc gggcgtgctg ctggcgccgt tgtgccaggt cgccggcctg tgggcggggt
     1561 ggaccgggcc gagcacgccg atccggtccg cggcggcgct ggcgatgcgg ccgtcacgcg
     1621 tgccggcgtg gctgcagaag cggcacgtgt gagtttcgga atgctcgtca ctcgcgctgg
     1681 ccggggtgag cggccgttaa ctaggctcga cggcgacttt gactctcaac gaggagttcc
     1741 gtgatgcctg aggccgtgat cgtctccgct gcccgctccc ccatcggccg cgcgggcaag
     1801 ggctcgctga aggacgtccg tcccgacgac ctggtggcac ggatgatccg cgcggcactg
     1861 gacaaggtgc cgcagctcga ccccgcgcag atcgacgacc tgatgctcgg ctgcggcctc
     1921 cccggcggcg agcagggctt caacatggcg cgcgtcgtgt ccgtgctgct gggctacgac
     1981 aacctgcccg gcacgaccgt cacccggtac tgcgcctcgt cgctgcagac cacccgcatg
     2041 gccctgcacg ccatcaaggc gggcgagggc gacgtgttca tctcggccgg tgtcgagacc
     2101 gtgtcgcggt tcgccaaggg cagctccgac tcgtggcccg acacgcacaa cccgctgttc
     2161 gccgaggccg aggcgcgcac cgccgccacg aaggccgccg gcgccgagga gtgggtcgac
     2221 ccgcgcacgc tggacgtcgt cccggacgtc tacatcccca tgggcgagac cgccgagaac
     2281 ctggctctgc tcaaggggat ctcgcgccag gagatggacg agttcggcgt ccgctcgcag
     2341 aacctcgccg agaaggccat cgcggacggc ttctgggccc gcgagatcac gccggtcgaa
     2401 ctgcccgacg gcaccgtggt ctccgccgac gacggcccgc gcgccggcgt cacctacgag
     2461 gccgtctccc agctgaagcc ggtcttccgc ccgaacggcc ggatcaacgc gggcaactgc
     2521 tgccctctca acgacggcgc cgcggccctc gtgatcatgt ccgacacgaa ggcccgcgaa
     2581 ctcggcctca ctccgctcgc ccgcatcgtg tcgaccggcg tctcgggcct gtcgccggag
     2641 atcatgggcc tcggcccggt cgaggcctcg aagcgcgcgc tggcgctcgc gggcctgtcg
     2701 gtctccgaca tcgacctcgt ggagatcaac gaggcgttcg ccgcccaggt catcccgtcc
     2761 taccaggacc tcggcatcga cctggaccgc ctgaacgtca acggtggcgc catcgccgtc
     2821 ggccacccgt tcggcatgac cggtgcccgc atcaccacga ccctgatcaa ctcgctgcag
     2881 ttccacgaca agcagttcgg tctcgagacc atgtgcgtcg gcggcggcca gggcatggcg
     2941 atggtcatcg agcgcctgag ctgaccattc gtcaagatct gcaaattgac gcctgcaagt
     3001 agctccgctt cacccgaacg gagctacttg cctgccccct ttccgccgat gagacaaaca
     3061 tcgctcaatg gcgtcatcag gcgaggggaa gtccgtccct accgatgagc aaggaggggc
     3121 cggacatgcc gtacgtgtgg tggcaaagcg aatacgacct gcaatgccac gctttctctc
     3181 tcgatcaagc cgatgggtcg cgcagctttt acgaggccgt gtgcgaacat tcggttcccg
     3241 acgaacgcgt ctcgcgcgcc caggccggtg cgttgtgcac cgactgcctg atcaaggtgg
     3301 gcagcgacct gccggacgtg cgctggcggg tctagcgccg ccacatcccg actgagtccg
     3361 gtgcgctctc cacgaagccg tgtcgtgcgt agagacgacg gccgggcggg tcggcgagca
     3421 ggctcacgag cgcgcctggt gctgtctcgt ggatcttcgc gagcagcgcg gtcaggatcg
     3481 cgtcacccag gcctttgcgc tggtgctcgg gcagcaccgc catgtcgatg acgacgaagt
     3541 acgtgcctcc gtcaccgacc acgcggccca tgcccgcggt ttcgcctgat tccacgtgaa
     3601 tgacacttgc gctggcccat gcgccggtga ggcccttttc ggcttcttcg cgagggcgtt
     3661 cgctcagtcc tgattctttg cgcaggcgct ggtagtcgtc gagcgacggt ggttccagga
     3721 caagccgata tgcggtgtcc acgcattccc cctcagttgt gcgcgttgtt cgtgcgatga
     3781 cggtagaggg cgattcgcgc ctccttggtc cgcaagggcg accggatcga cggcacacca
     3841 cccgctcacc gtcgattcgg aacatctcag tcagttcctc gacaagctcg gccacaggcg
     3901 gtcgcagcag agcggaaccg tcctcggatc atgccgatca cggcggcgtc acgaggttcg
     3961 gcgggcctcg tccccgccga acgccgaagg ggcgccccgc cgcagcggaa cgcccctcca
     4021 gcacacccga agcgtcagtc cgagttgaag tacgacagca ggcgcaggat ctcggtgtac
     4081 agccacacca gggtgaccgt gagaccgaac gcgatctgcc acgcgaactt ggccggcacg
     4141 ccggcgcgga tcgcctggtc ggcggcgtcg aagtcgatca ggaagctgaa cgccgcgagg
     4201 ccgatgcaga cgaggctgaa gatgatcgcg agcggaccac cgttgcgcag gccgaggccg
     4261 ccgtcggtga agaagctcat gatcaggttg aagagcatga ggacaccgac gccgatgagc
     4321 gcgccgacga tccacttggt gaacttcggc gtgacgcgga cggcgcccgt cttgtagacg
     4381 acgagcatgc cggcgaagac accgatcgtg ccgatgatcg cctgaccgat gaccaccacg
     4441 ccctgtccgg gcttgttggt catgccgtcg atcatgttgc cgatgatgcc gctgaacgcg
     4501 ccgaggaaga tgccctcgac ggccgcgtag gcgatgacca gcggcgggct cggcatgcgc
     4561 ttgaacgtga tgatcagcgc gagcacgagg ccgatgatcg cggccgggaa cagcaggaac
     4621 cacgcctgca tgaggtaggt gacgacggcg gtcgcggcca ccacggcgag cgtgatgccc
     4681 gtcttggtaa cgacgtcgtc gatcgtcatc ggccgctcgc tggtcagcgg cggcggggcc
     4741 tgctggtagc cagcctgttc tggctggccg aagcctgcgt agcctccgta cccgccgccg
     4801 gtcggcaggt tacggaaagc cgggttgctg ctcgagcgca cctggtcctc ctggggcgtt
     4861 gctttacgcc gtcacggggt acaacgagca cgctcggtgc catgttcccc gtcggtaaag
     4921 gcgactttac ccccgacgac gatcacacgt gcgcaaatac tgcggtaact ccggagcgtt
     4981 atgagactgc ggcgtgtcgc ggcgtgtctt ccaccgcaga cgtaagccca gtcacattcc
     5041 attcacagtc acaccctcag tgacgacaca cttccccctc gtggcggctt gtccccggtg
     5101 tgggggaacg agaagctcgc acgcgggatc tcacaggtca gaggggatga cgattcacca
     5161 tgggctggaa acgtctggcc gccgtggcga tggtttcggg gctcgcgctc ctgaccgtcc
     5221 ccgcgacggc gaccgctgtc ggcgtcaagg gcatcggcca caacgcgtca gggctccagc
     5281 ccaacgccac accgggtagc gagtggcacg gctcatacat ctggcaggac aagcaggtgt
     5341 ggtgcgtgca gtacgcgctg cccgcgccgg acagcaccgt cggctacaag gaaggcgacg
     5401 cgctgcgcac caaggcgggc aaggacctcg cccccgacat cgcggcgaac atctcctacc
     5461 tgctgctgcg ctactcgacg accaagtccc cggacgaggc cgcagcgctc gcgcacctgc
     5521 tgcacagctg gacgtcggct cccgacggcg aggtcacgta cgacacgacc gacgccaagc
     5581 gcctcgccta caacgcggag ttctacgccg cgcgcctgcc gcagtccgtc atggacaccg
     5641 tcgcgcgcat caaggccgac gccgaggcca accgcggccc gtggacgctc accgcgaccg
     5701 cgccgaagga accgctggtc atcgacgccg agtccagctg gacgctgtcg ctggtcaagg
     5761 ccaacgacaa gggcgtcacg aacgccccga tcgccttcac cctgaccgac gcgaagctcg
     5821 ccgacggcgc caccagcggc acggcgacca cgggtgcgga cggcagcccc gccgtggtca
     5881 agctcatcgc caccggcccg aagccgtcga tcgcggccgt cgcggactcc cccgccgacc
     5941 gcccggtcgt gcacttcccc atccagaccg agaacatgca gcgcatggtg acgaccggtg
     6001 gcgagaagaa gctgaacgcc gccgcgaaca ccaccgcgaa gaccgcgccc ggcgccgtga
     6061 agatcacgaa gatcgactcc gagacgaaga agtcgatcgc gggcgtcgcg ctgcgcgtca
     6121 cggccaagga ccagacgtcc gcggcgaaga agcaggacga caccgacctc gtcggcacgg
     6181 acggcaagcc gctggtgctg cagaccggcg ccgacggcac ggtcgaggtg ccggacctgc
     6241 gcaccccgca ggagatctgc ctcgtcgagg tggccgcccc caaggggtac gaggagttct
     6301 tcgacccgaa ggcgccgccg tccgcgtgcg gcacgctcgc ggcgggtcag acgctcgcgc
     6361 tggaactggt gaacaagccg aacaagccgg tcttgcccag cacgatcccg gcgggcgcgg
     6421 acgggcagac gccggtcgcg acggcgtcgt tcgacacgca gctgcgtccg ggcctgatgc
     6481 tggcggtggg cggcctcgtg ctgttcggtg cggcactggc aggcttcctg gtgtggcgga
     6541 ggcagtgagt ggcagggctt ttctgaccgg ggcgctggtg gcgggtgtgg ccgccgccag
     6601 cgttctggtc ggcacgtccg agaccgcggt cgtcaaggga cgcgcggtcg cggacgagat
     6661 cccggtggtc gcgccggggc cggtcgcgga cagcctgagc accggccgcg gtcccgacct
     6721 caccggcctg gtcggtggtg cgaacacggc caacgccaag cccgccgagc cggctccgca
     6781 gcaacagcag cccgcgccgc ccaaggcggg tccggggtcc gtgcggctgc ctgcgggcgg
     6841 ttcggcgacg ctggtgcgca aagaggtgaa ggacggcgtg ctgcccgtgc ccgacggcat
     6901 cggcgaggcg acgtggtggg gcaccgagat cagtggcgcc gagggcgcga cggtgctggc
     6961 cgggcacgtc gactggaagg gcgcgaaggg cccgttcgcg gagctgtggc aggcgcagaa
     7021 cggccgtgag gtcgtgatcg ccgacagcgc gggcaaggag ttccggttcc gcatcaagca
     7081 gatcgagacc gtgcgcaagg aggagctccc ggcgcgcgcg gtcgagttct tcggcccgcg
     7141 cggcccgcac cggctggtcc tcgtcacctg cggcggcacc tggatcggtg gtcagcaggg
     7201 gtacgaggcg aacagagtgg tcatcgccga acccgttcag tgaccaatcc tgtacctcac
     7261 gcaacccgtt cgggtaacta gtcgtctcct ttagtgtgaa acggtgggga tggttgacca
     7321 cgggtgtggc gctgggtctg gtactggcaa tggtgtggac cctcgggtcg cacgacgaac
     7381 agaccccggt gtcggactcg ggtcccctgc cgatggcgcc gagactgccc gctccgaagg
     7441 acgcggggcc gacgccgacg gtgcccgccc ccacccccga gcagctcgcc aagcagccgt
     7501 ggatgcacaa gctcgcaccc ggtgagaagc ccccgcagtt cgtgctcttc tccttcgacg
     7561 gcgcggtgtc gaagcagcac tgggacaagg tcctgccgat cgcgaaggcc aagaacgcgc
     7621 acgtcaccgg tctgctgtcc ggcgtgtaca tgctggccga ccaggacaag ctgcagtacc
     7681 agccaccggc gggcctcaag cgcggcgtct ccgacatctc gttcggcggc accaggcagg
     7741 acatcaccgc ccgcatcggc tacctgaacc aggtgatcgc cgacggccac gagatcggca
     7801 cccactacaa cggccacttc tgctccggcg gcacgcagcc gtcggtcgac aagtgggaca
     7861 ccgcggcctg gaaccaggag ctcgaccagt tcaagcagct cgtcgactcc tcccgagccg
     7921 cgggcctcaa cctgcccgcc gacgccgtcc ggggtggacg gacgccgtgc ctggagggca
     7981 actgggacca ggccttcccg gcgatggccg cgcacgggct cgtctacgac acgagcaagg
     8041 tcgcgctcgg cgtgcagtgg ccgaccgtcc agaacggact gtacgagttc ccgatgcccg
     8101 aggtacgcgt tcctgcgctg ggcaagcagg tcgtgatgat ggacttcaac ctctggtact
     8161 cgctcaacaa ggcgcaggac gaaccgcacc gcgccgccga cttcgcccag atcgtcctcg
     8221 acacctacaa gtcggtgcac caggccgcgc tgaacggcaa ccgcgcgccg atcgtcgtcg
     8281 gcaaccactt caacgagtgg aacggcaacg cgttctcgac ggccatggag cagttcatgg
     8341 agtacgtgtg cgacaagccg gagacggtgt gcgccaccta caccgaggtg atccagtgga
     8401 tgcagctgca ggacccggcg gtgctcgacc agctccgccg gatgcccgca gcccgcaact
     8461 gacagcgacc cgggtcgcta gccgtcggtc gagatgatcc ggtcgtcgtt cgctcccggc
     8521 gagccgttcg cgtcctggtt ggacgtgccc agccacagcg tgccgtccgg cgccgtcgtc
     8581 accgcgcgca cgcggccgta gcccgtgaac acggcctgcg gggtgccgag ggtggtgccg
     8641 ctgaccggga tcttccacac gcgcttgccg gtgacggcgc cgacgtacag ggcgttcttg
     8701 tagaacgcga tgccggtcgg gcccgcctga ctcgtcgacc aggtcttgac cgggttcgtc
     8761 atgcccgaga cgttgcagtt gccctcacac gtgggccaac cgtagttctt gccggcctcg
     8821 atgcggttga cctcgtcggt cgtgttgttg ccgaactccg tggcgtacgc ggtgctgccg
     8881 atccacgtga tgccctggac gttgcggtgg ccgatcgagt agacgacgct gcccgcgcgg
     8941 gggttgcccg ccgcgggctg ccccgcggtg tcgaagcgga ggaccttgcc tcccagcgag
     9001 ttccagttct gggcgttcgc ggtgttctgc ccgtcgcccg tggtggccca caggaagccg
     9061 tccggacccc attcgagccc gccgccgttg tggtagcggt tcttggggat gcctgtcacg
     9121 atcggctgcg gcgtaccgcc gagctgcaac ttggcgacgc ggttgtcgct cgccgtcgag
     9181 tagtagatga agaccgagtt gtcggtcgcg aagctcttcg agaccgcgag gccgagcagt
     9241 ccgccctcgc cgcccgtggt ctgggcctgt tccaccgtgt ccagttcggt cacggtcgtg
     9301 ccggagatct tcttgatctt gcgggtgtcc cgctcggtga agatgccgct gccgtccggc
     9361 aggaactcga tgtcccacgg gatgtccagc ttcgtggcga gggtccgctc ggccaggacg
     9421 gagggatagt cctgggccga cgcgggcacc gcgcagaggg tcgcggccag ggcagtgcag
     9481 gctgccgccg ctgcgattcg acgagcacgc atgtgctctc cttctcgtcc gctcgaggtg
     9541 tggctgcggc ggcggtgttg cagggcgtgt tcacgcaatc acacatcgcg aagcgccgca
     9601 acagtcgtcg gaggtcccgg tattcccggt cgtcgtctga gtgaaaccgg cggcgatccc
     9661 tccgatgact tcaggtcact ttctgtacgg tctagaccgt ggtggcccgc accacctacc
     9721 gtgtggtgcg ccgccgcgcc ctcacggaaa gcgcttgcac gcccggccgg gcctgcgggc
     9781 aggagaccga ggagttgcgc atgaacgttg ccgtcaccac gaccgagacc aagctccccg
     9841 aggtcaggcg cgagtgggtc aagcccgact tccgcgactt cgagacgccg atggaggtca
     9901 ccgcctacgc ggcgcgcagc tgacgtcagg tggtgggccg gggttccgcg ccggagcccc
     9961 ggcctctcgc gcgccctccc ctgccgaccg aggagttccc atgtccgccg ttcctcccgc
    10021 ggagttcgtc gccgaactgc gcgccctcgc accccggtac tgggacagcc acccgttcca
    10081 cctgcgcatg cacgcgggac aactgggcaa gcacgagctg caggcgtggg ccgcgaaccg
    10141 gtggtactac cagcgctgca tcgcgcagaa ggacgccgcg atcctctcca actgcccgtt
    10201 gcccgagatc cgccgccagt ggcgcgagcg gatcgtctgg cacgacggca cgaagcccgg
    10261 tgagggcggt gcggagaact ggatccgcct cgccgaggcc gtggggctga ccagggacga
    10321 ggtgctcgac gaacggcacg tgctgcccgg cacgcgcttc gccgtcgacg cctacgtgaa
    10381 cttcgcgcgc accaagccgt gggtcgaggc catcgcgtcc ggactcaccg agatgttctc
    10441 gggggcgttg atgcgcaagc gtttgacggc tctgcgggag cagtacccgt ggatcgccga
    10501 ggaggggttc gcctacttca cgaaccgcat cgaggccgtc gcgggtgaag gccgggccac
    10561 tgtggacatc gtggtcgagc actcgcggac ccgtgaacag caactggccg ccgtcgccgc
    10621 gctgtcgttc aagtgcgatg tgctgcgggc cgtgctggac gccgtcgact actactcggg
    10681 caggggcagg ccgtgaccgt ggcgctggac gccgtgccgc ggatccggcg cggggtgaag
    10741 tgcacctacg accagatccg ggaggcgcac gtcgtgctgt tccccgaggg tgtgctggtg
    10801 ctgaacgaga ccgcggcttc cgttgtggcg ctgtgcgacg gtgtccggtc catcggggac
    10861 atcgcggtcg cgctggccga cgagtacgcc ggggtcgagc ccggcgacgt ggtctccctg
    10921 gtcgtccgca tggtcgaacg gagggtggtg gacgtggatg gctgaggcgc ccttcgggct
    10981 gctggccgag ctgacgcacc ggtgcccgtt gcagtgcggc tactgctcga acccgctgga
    11041 gctggtgcgc cgcgacgccg agctgtcgac cgaggactgg cggcgcgtct tcgaccaggc
    11101 ccgcgcgctc ggcgcgttgc agatccacct gtccggcggg gaaccgctgc tgcgccccga
    11161 tctccccgaa ctggtggcgc acgcgaacag cctcggctgc tacgtcaacc tcgtcacgtc
    11221 cggcgtggga ctctcgcgcg accggttgcg aacgctggca tctctcggcg tcgaccacgt
    11281 gcagctctcg ttgcaggacg cgactcgcgc cggcaacgac cggatcgcgg gcatcaaggc
    11341 gttcgaccgc aaggtggaag cggcctccca cgtgctggac gagggccttc cgctgacggt
    11401 gaacaccgtg ctgcaccggc agaacctcga caacgtcgcc ggcatcatcg cgatggccga
    11461 gcggatgggc gccgagcgtc tggagctcgc gaacacccag tactacggct gggcgctgcg
    11521 caaccgcgcg gtactcctgc cgacgcggga gcaactcgcc gccgccgatc cggtcgtcgc
    11581 cgcggcgcag gaacggctgc gcgggcgcat ggagatcgtc tacgtcatcg cggactacca
    11641 cgaggcccac ccgaaaccgt gcatgtacgg gtggggtgcg cggcagctga cggtggcgcc
    11701 gaacggggac gtgctgccct gccctgccgc cacggtgatc tcgtcgctcg agatcgagaa
    11761 cgtgcgcgac tcgtcgttgc acgacatctg gcaccactcg ccgtcgttca acgccttccg
    11821 cggcttcgag tggatgaagg acccgtgccg gtcgtgcccg cgcaaggagg tcgacttcgg
    11881 cggctgccgc tgccaggcgt tccagctgac cggcgacgcc gccgccaccg accccgtctg
    11941 ctcgctgtcg cctgatcggt ccactgtgga cctgatcctg gagaccgaga tggcgcccgc
    12001 cgaagtgccc gcgatggcga tgaggaagat gcggtgaagg cggttctgct cggcacgacg
    12061 gccggtggtg gtttcccgca gtggaactgc gcgtgctcgt tgtgcgtgcg tgcccgttcg
    12121 ggggcgttgc cgtcgcggtc tcaggactgt ctggcgatca gcggcgacgg cgcggactgg
    12181 tggctggtca acgcctcccc ggacatccgc acgcagatca cctcgtgctc gttcctcgac
    12241 cccggtcccg gcgcgcgcga gaccccgttg cgcggcgccc tgttcaccga cgcggagctc
    12301 gaccacaccc tcgggctgct gacgttgcgg ggtggcaagg gtgtgacggt gtgggcgccg
    12361 gctccggtcc tgcgcgcgct gaaggacgag ttcgacctgc gcacggtgat cgacgggtac
    12421 gcgccggtgg cgtggcggga ggcggccggc tcgttcgacc tcggcggcct gcgcgtgacg
    12481 gcgatcccga tcagcggcaa gcggccgaag tacgcgcggt cgtccactgt ggacggtgac
    12541 tgggtggtcg cctaccggtt cgaggacccg gtctccggtg gtgtgctggt ctacgcgccc
    12601 tgcctggcgg cgtggccgga cgggttcgac gaggtggtcg cgggggcgga ctgcctgctg
    12661 ctcgacggca cgttccacgc ggcctcggag atgggatcgg cgaccggcag cgcgtccggg
    12721 caggccgcga tgggccacct cccgatcacc gcgagcctgc ccgagctgcg gcggttcccc
    12781 ggcgtgcgcc gcctctacac gcacctcaac aacaccaacc cggtgctcga cccgtcgtcc
    12841 ccggaagcgg tggaactgca cgaggcgggt gtggaggttc cgctcgacgg cacggtgatc
    12901 gagctgtaga tcggccacaa tcacgggatg tcctacgtga tcggcggccg gccgctggcg
    12961 gcgcgactcg tcgcggagat gccgtcgttc gtgcggcagg tgatcgaggc gctggtggag
    13021 cgcgtaccgg cgtactccca gctgcccgcc gaagaactcg ccggcgacat ccaccgcgtc
    13081 accgagcacg ccctgcgcgc gttcgcccag gtgctctcga ccggtgagct gccgtccgcc
    13141 gcagagctcg cgttcctgcg cgagtcggcg gcgcggcggg ccgaggaggg cgtgccgatc
    13201 gacgtggtgc tcaccgcgta ccacgtgggg atccaggtcg tgtgggacgt gctggtgccc
    13261 gaggcgcgtc ccgaggaggt ccaggacgtg ctggcgctga acgcgctggc gttgcggtac
    13321 ctgcagctcg tgacgcccgt ggtgagcgcc gggtacctcg acgagcgcca gacgatgttc
    13381 gacgacgagc gctcggcccg tgccacgctg ctgaccggcc tgctcgccgg aaccgtggag
    13441 gcgccgggac ctttcgtcgt gttcgccctg cacctgccgc cccaccccga cgagctgctg
    13501 cccggggtgg acgccgccgt cgcgtcccgg cggaagctgc ggcgggtgcg cacggaactg
    13561 gagcggcaca gccgcgaacc ggtgctgtcg tcgctcacgt ccgacggcgg cctcgccctg
    13621 ctgccgggcg aggacctgcc gtgcgaacgg atcgtggcgg acgtgacgcg ggccgccggt
    13681 gtgccggtga cggtggcggc ggtcgcggcc ggtgcgtccg gcgtcgcggc cgccgccgtg
    13741 ctggcacggg aggtgctggc cgtcgcggtg cggtcgggtc cgggcctgta ccggctcacg
    13801 gacgtgctgc tggagtacca gctctcccgc cccagcgccg cattggagcc gttggccgcc
    13861 atcgtcgagc cgctgaccga cgagctggtg cagaccctgg aggtctacct ccggcgcggc
    13921 tcacggcgcc cggccgccac cgagctgcac gtgcacccga acaccgtcga ctaccggctg
    13981 cggcgcgtcg cggagctgac cgggctggac ccgacgcgga tcgagcacgt cacgcttttg
    14041 acggctgcgc tggccgcacg gcgttcgcga ccgtagcgcc gaaggccgcc atgcccgccg
    14101 cgttggggtg cagcggcgcc gcgaccgtcg tcgggaccag gccctccagg taccggtcgg
    14161 cgggcttggc gcacgtgtcg tgcccgacgc tgacggctgc gaggtccacg taggtcgcgc
    14221 cgcgcttctc cgcctcagcc ttggccgtgg cgctgagcag gtccaccgac ctctgcagga
    14281 agtcggcgtc gcggccccag atcggctgga ccgggtagca gccgccggga cggatgtagg
    14341 tgccgtagcc ggtgacgagg accttggcgt gcggtgcgcg gcgcttgacc tcgtcgaggg
    14401 cggccccgaa ctcgggcgcc cacccgcgga tggccgcggc gacctggtca ccgcccgcgg
    14461 tcagccgggc ctcgcacgag agaccgacgg gttcggggag caggttgatg cagcccagcg
    14521 cggtctgcac gagcccgacg tcgttgccgc cgatggtgat cgacaccagg tcggtggtgg
    14581 gcttcagcgc gtcgtactgc ggcgcgacga acccgaactg gcggccggcg aagtcgtcgg
    14641 tcttggcgcc ggagcaggtg acgtcggtca gcctcgcgcc gagcagcttc gcggcgacct
    14701 gcgggtagtt gcggtcgctg cgcaggcacc acagcgccgg gtccgggttc gggatcagcg
    14761 gtcccgccgc cgccgagtcg cccagggcga cgtagtcgag ggtgtccgcc tgcgcggtgc
    14821 ttgttccggc gaccaacatc gccacgacag ccagcccggc cacgattcgc atcccgatcc
    14881 tccaacgtcg ttgtcaggtc agctcatcgt ggtggctctg gtcaccggtg cgggtaggac
    14941 gttgcccaga gtcatccggt cgtgtttgtg accgatcaca atgggagtgt gactcctgcg
    15001 gatctcctgt cgttggccac ccagtcctgc gtggacgccg cgaagctgtt gcgcgagatc
    15061 cgcgtggacg tgtccgcgaa gggcgcctac gaccaggtca gcaccgccga cctcgaactg
    15121 gaggcgttcc tgcgggcgtg cctgaccgag ggcgctcccg gctctgcggt cgtcggcgag
    15181 gagctcggca gcgcgtccgc cgaggtcacg tggttcgtcg acccgatcga cggcacgcgg
    15241 aacttcgtgc gcggcctccc gttgtcgtgc atctccgtgg ccgccgccgt cgacggcgtg
    15301 ctggtcgcgg gctgcgtgct cgacccgttc cgcgacgagc tgttcacggc ggcggcgggc
    15361 gtgccgttcg gcgttcgctc gaccggcctg gtgattccgc cgggggtgag cccgcggccg
    15421 ctcgtgctga ccgacatccc gttgcccggc agcccgtacg agggcgaggt ggagttcctg
    15481 gccgacctga tggaacgggc ggacgtgcgg cgcgtctact cgactgcgct gtcgctcgcg
    15541 tgggtggcgg cgggcagggc ggacgcggtg acgaacatcg gcatccaccc gtgggacgtc
    15601 gcggcgggcg cggtgctcgt gcgcgaggcc ggcggggtgt tcaccgggat cggccacacc
    15661 gcgttcgccg cgggcagggg tgagatcgtc ggctggctgg cggaccgggt ggagggcatc
    15721 gtctcgtgat cgatctcagc ggcaaggtcg tgctggtcac cggagcgggc ggcaccatcg
    15781 gcgcggggat cgccgcccgg ttcgaggccg cgggcgcact ggtcgtccgc cacctgggcc
    15841 gcgaggacgg cgacctgcgc acggaggcgg agcgcgtggt cggtgaggcg gccgcacggc
    15901 acggcaggct ggacgccgtc gtgaacaacg cgggcgcgca gcccgtggac ccgttgccgg
    15961 gcatgacctc cgagcggtgg cggtccgtcc tggacacgaa cctgaccggt ccgttctccg
    16021 tcacccaggc cgccgtcgca cacctgccgg cgggaggctc ggtcacgcac atcgcgtcga
    16081 tcgagggcac gcaccccgct cccgggcacg cccactacgc ggcctccaag gccgggctga
    16141 tcatgcacgc gcgggcggcc gcgctggagt acgggccgcg cgggatccgg gtcaacacgg
    16201 tctcccccgg cctcatcgcg cggcccggca tcgaggagca gtggcccgaa ggcgtcgcgc
    16261 ggtggcggga ggccgcgccg ctgacccgcc tcggcacgcc cgaggacgtc ggcgacgcgt
    16321 gcgtgttcct ggcgagcgac ctcgcgaagt ggatcaccgg gcacgacctc gtggtggacg
    16381 gcggagtgac ggctcggccg acgtggtgat cccgttgcgg cggctgccac tacacagttg
    16441 acacctttcc gtcacgttca gtagtcaatc acaccactac cccaattcgt acagaaccga
    16501 cagggtccga cggcctgtcg gcggctttac ttatcacctg gcataagacc aggttagacg
    16561 cggtacgtga cgtcccctct accgtgcgta tcaatcgact atggaatgtc tcaactgggt
    16621 cacaggatgg atttgagcta cccagagtga taacacccgc gtctcttccg tcgaaaggtc
    16681 aacagtcgac ttggaccgga gggggacgga cgacatgaca tccgagtacc gaccgatttc
    16741 ccgacgcacg ctcctgaccg ccgcactcgg cggggctgct gtgggcgtcg tcggacaagg
    16801 cctgttcgcg ggagccgccg gcgcggcacc caaggcgggc cgccagaagc ttctgatcgg
    16861 cagcgtggac cgcctcggca acggcgtggt gcagctgacc gacccgagcc tgaccggcga
    16921 gcagacgctc gtgccggtca acggacagcc gaacgggatc gtgggctcgc ccgacggtct
    16981 gcgcgcttac gtggggacgg tcttcgggcc gggtctgagc gtcgtggacg tcgacggcgg
    17041 ccgcgtgacc ggcgaggtcg ccgtcggcgg gttcgccaac gagctgctcg tctcgcccga
    17101 cggcaggacg gtgtacgtgg cgaccggctc cgccggtgcc ggtggctcca gcgggcacgt
    17161 ggccgtggtg gacacggcga gcggcgaggt ccgggcgagg atcaaggcag gcctgctgcc
    17221 gcgctcgctc gcactcagcc cggacggcaa gcagctgttc gtcggtgacg agcgggccaa
    17281 gggcgtcacg atcgtcgaca ccgcgaagaa cgccgtgtcg ggcaggttcg agaccgacgg
    17341 cacgccgctg ctgatcgcca tcgatcccaa gggcaagaac ctgtacgtgg cgcagtcgcg
    17401 tgagctggcc acgttcggcc tgcgcggcgg caagtccggg gcgaccgcac tcgacggcgt
    17461 cccgtgcggc ctggcggtgc acccgaacgg cacgttcgcg gccgtgagcc tttacgcggg
    17521 ccgcaactcc gactcgcagc tggtcacggt gaacatcaac tcgaacaagg tcaggacgaa
    17581 ggagtccaac ggcaaggcga acggtcctct cgcgatgagc aaggacggtg gccgggcgtt
    17641 cgtgctggac gagaagaacc gcaaggtcac gtccgcggac acgaactccg gcaagccgga
    17701 cagctctttg ccgaccccca actcgaacac gccgacctcc gtcgcgttcg tcgagaccgc
    17761 ctgagcgccg gagggaactc gcgatgccca tctccatgtc cgtgaagacc ctggactaca
    17821 ccccgacctg gccgccgtac cccagtctgt ggatgggcgg ctacggcggt gcgccgcgcg
    17881 gcaaccaggg cgcggtcgac cgcaggctgc gcgcccagtg catcgtcatc gacgacggag
    17941 ccggccccaa ggtcatgctc cgcatcgacg tcgtcagcat tcccagatac gtgcaccagt
    18001 cgatcagatc ccaggtgctg ccgttggtga acaacgagaa cggcaacttc ctgatcatct
    18061 gcagccacac gcactccggc ccgttcatcg gcaccacgcg cccgcacccg tacgtgatga
    18121 tgagcctcac cccggcggac atcagcgcga tcgaggacac gaccaacgtg ttcatctcgc
    18181 agatggtcac cctcgtgcag cagaccctcg cgatggcccg cacgcaggtc acgttgtggt
    18241 acaaggaagg caacgcgtcg atcggctaca accgcgccgg tgagcccaac gtcctcacca
    18301 cggtcaacgc gctgatcgcc cgccgcacga gtgacaacgc cctgcagacc gtcctcttcg
    18361 gatacgcctg ccacgccgtc gcgcgcggca acgacaagac gttctgcagc gacttccccg
    18421 gcgccgccac cgacgtgatc agcaacgcgc tcggcgtgca ggcgctgttc ttccagggcg
    18481 cggccggcga ccaggagccc aacgatcccc acagcccgag ccaggtcacg aacctcggca
    18541 cgatcctcgg caacgcggtc gtgtcgatgg tgaactcggg cggctggacc gccgtcaccg
    18601 ccccgatcac cacgtactac caggaactca gcctcccgtt caccgtggac ttcggcgacc
    18661 cggccgcggt gatccgcgcc cgcaacagct acaacgcccg gctcgacaac ctcgcaccgg
    18721 gcgactacgc ctaccgccac gccgaggtca tgctcgagca gatcgcgggc ccgggcctgc
    18781 cgcgcgtgtt cccgatgccc atccagcgct ggaagctggg cggcctcaac atcttcgcga
    18841 tgtcgcacga ggtcctgtcg gagtacgccg tgaacctgcg caaccagatc ccgggcaacc
    18901 tctgggtcat ggcctacgcc aacgagaccg agggttacgt ggcggccaac ggcatcctgc
    18961 aggacggcgg cgccgtgcgc tggggctacg aggccggctg ggtcgacgac cccgagatct
    19021 ccggcgaagc cacgtggacg acgttctacc cctggcccgc accgctcaag ttcagcccga
    19081 gcgggcccgc agcgccggga acgaccgagc gcatcgtcat ggacgccagc acagcaatgc
    19141 tgaacctctg aggggtggat cgaagaaatg ccaggaccaa gcaccacttt gtcgtcccgc
    19201 tacggcctcg caccggtcta cccgtgcggc acgaccggta acctcttcct gttcgagcac
    19261 tcgacaccgg ccaccggaac cttcgcctgg ggccagagct accagatcgg cgcgggctgg
    19321 cagggccgcg tcatcgccgg cccgagcggc tggatgttca gcatcaccac cggcggcgag
    19381 ctcagagtcc tgcactacaa cggaaccggc tgggacctgc tcaacggcag ccagtacctc
    19441 gttctcggcc agggctggaa ctacaccgcg gcgaacaccc gcaaccggat cacggtggac
    19501 gaggacggcg tcatctacac cctcgacgcc gcaggcaacc tcaaagcgca ctacttcaac
    19561 ttcacgaccc agcagtgggc cgtgcagggt gcgctgctcg agacgggcct gacccagtac
    19621 aacgcgatcg ttgccaccag ccgaggcgtc atctacgcgc gcaacgcggg cggcgcgatg
    19681 taccgctact acatcgactt ctggtccggc gccacggcga cctgggtcaa gccggtgtcg
    19741 acggtcacca cgggctggca gaacctgaag cacctcagct cggccggcgg cgagacgttc
    19801 tacgccgtga accagaacaa cggcaacctg ctctggtaca gctacaaccc ggtcaccaag
    19861 gtgtggaaga acgccaagat catcggttcg ggctggaaca gcgagcagga cgtcgtcgtg
    19921 cagtccaaca tctgttcgcg cttcccctgg gagaccgcgt gcaactcgtt cgggatgcag
    19981 gacggcgggg ccgtgatcac gcggctcaac caggtgaaga agaactgatc tccgcttttg
    20041 gggcccgctc tcggcattcg tgccgggagc gggcccttcg cgtcactcgc cgacgaggta
    20101 ccggtaggac accggcgtga ggttgggctc cttgaccgcc cacgggcgga tcacgcgcag
    20161 ggtgccgccc gacgcctccg gcggtgacac cgagcggtcg agcacgatgc cgctgacgac
    20221 caacagcatg ttgttcgggt actcgcgcag gtgcagctcg acctccttgc gcgtcaggat
    20281 gatctcggag gcgtccgtcc acgtcgtggt ggtgcctttg acctcgacgt agacgcgctc
    20341 gtccgcacga cgggcatcga ggtcgtagga ctccttcgtc ccgacgtcct ccacgtcgta
    20401 cccctgctcc tccaggtact ccgtcgccac cgcgaccgcg cgtcgttcga tcgcgatccg
    20461 ttccggcgca ctctgacgaa gtccctgccc actgcgggcc ttgcccgccg accgctccgc
    20521 ctcgacctcc gcgtcggcga tctcgggagc cgtcgtaccg tggtcgagga gctcgtacag
    20581 ctcgctgagg acggagacga ggaaggtcag gtcgtcggca agtacctcgt cagaaggcaa
    20641 gtcccgcaac gggtactcga acgcgacgac ggtgccgtcc tcgtacgccc gccccaactc
    20701 ggaccgggtg gccttgagtt cgatcgcgtc gacgaggtcc ggccgcgccc gcagactcgc
    20761 cgacagcgcc tcccgcatct cgtgcgcccg ttgccgcagt ccactccccg gcaacccctt
    20821 gtactcgcgg ttcttcttgc ggctggcggc ctgcatcagc gacaggtaga cccgatcgcc
    20881 cggtgccgcg aacaggtaga cgacgtacca gcccttcgtc gcggaaggcg aacggctgct
    20941 cgaatgcact cgcgcccaag ggatctcggc cctgttgccg gcgccgtcac tgctcccgac
    21001 ccgccagtcg gtgatctcga ccggagccgc acgtcggagg tcgggcaacc gctcccgcag
    21061 ccagttcgag atgtcgtggc ggatcagtcg gccgcgttcc tgcatctcag acgtgctttc
    21121 ggaagtccac tcggcctgga ggaccatgac gtcacggaga agctcacgca tcgggaacgg
    21181 gccaccacct tcacagcacg atcagtaatc tcaagatcgc acatggaccg ttcgggtgtt
    21241 actcgatcgt ggcggttgca cacccagcgc acccggtgat ctgcgggccg ccagagagct
    21301 gtgatcacca acacaaggcg gcggcagtgg tacgcgggca ccacttcggc acgggacggg
    21361 gcgcgcggag cgggagccga gccggtgtca ccgggagtta catgatcatc gcctgacggc
    21421 gtctgcgctg gtcaggcgat gatccataca ggtgaacgga agtacccccg acacggtacg
    21481 cactagtccc tccccttcgc gcacctgccg tgaactgcag atatccgcca ccgtcccaat
    21541 cacgcaccat agccaacggc gtggcagtaa atcttcccga acgatggcgc cagccgattc
    21601 agaacccgaa aatcccgcat cctcctgaaa atgcccagga aacattgtca taaatatctc
    21661 aacggcgcga gcggcatgtg caataaagtg gcccagcaac agtgttccaa cagatttccg
    21721 cagactcgct tgcctgaaac ggcgaacctt ccgaacagaa agactccgga ttaaagtgct
    21781 gaatggttac caaattctcc cttgacgcgc cccgtaacgc tccgaaggcg cgtgataaaa
    21841 tcgcgtacga ataaccctac ccttgctatc gcgaggctca ttaacgacaa aaatccgctc
    21901 ccgcacatcc ggaaatgccg ccaacttctc aacgagacga acattgtcag tcacgatttg
    21961 atattgacct gcagttaatg tcttttcatc aaacacgtct tccatgccac gaatatcgag
    22021 cagcctaagg ttcggca
//
