LOCUS       NZ_CP099738            22565 bp    DNA     circular CON 27-AUG-2024
DEFINITION  Lentzea sp. HUAS12 chromosome.
ACCESSION   NZ_CP099738
VERSION     NZ_CP099738.1
KEYWORDS    RefSeq.
SOURCE      Lentzea sp. HUAS12
  ORGANISM  Lentzea sp. HUAS12
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 9676923)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_024125735.1-RS_2024_08_27
            Annotation Date                   :: 08/27/2024 06:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,161
            CDSs (total)                      :: 9,080
            Genes (coding)                    :: 8,988
            CDSs (with protein)               :: 8,988
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 21 of 92
            Pseudo Genes (incomplete)         :: 77 of 92
            Pseudo Genes (internal stop)      :: 3 of 92
            Pseudo Genes (multiple problems)  :: 8 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:47:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5195484
            Orig. end                         :: 5218049
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099738.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ping Mo.
FEATURES             Location/Qualifiers
     region          1..22565
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="27"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22565
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22565
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12565](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12565
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(789..803)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.73"
                     /tool="antismash"
     gene            complement(919..1689)
                     /locus_tag="ND450_RS23170"
                     /old_locus_tag="ND450_23170"
     CDS             complement(919..1689)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099014.1"
                     /locus_tag="ND450_RS23170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23170"
                     /product="hypothetical protein"
                     /protein_id="WP_253320831.1"
                     /transl_table=11
                     /translation="MGSQITEGLGQAWAMIATFVPKLLGFLVVLLIGWFIAKALAKGVQ
                     FLLKRVGFEKLVDRSGLNGAMRQSSMDASGLISKIVYYFVLLIALQLAFGVFGASNPVS
                     TLLNEVIAYLPRIVVALVLVIVASAIGTALKGLVTGALGQRSYTKLMGNITYGFVMALG
                     IIAALNQLGIAVSVTMPVLIAVLATVAGVIVIGVGGGLVRPMQQRWEGWLARAQDEAQA
                     QSPMPRASQEMPQNVGARMGDAPTPPSGMPMTDR"
     misc_feature    1700..1713
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    complement(1804..1817)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.83"
                     /tool="antismash"
     misc_feature    1866..1879
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            complement(1910..3466)
                     /locus_tag="ND450_RS23175"
                     /old_locus_tag="ND450_23175"
     CDS             complement(1910..3466)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (87-274). E-value:
                     2.2e-17. Score: 55.4. Matches aSDomain:
                     nrpspksdomains_ND450_RS23175_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099013.1"
                     /locus_tag="ND450_RS23175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23175"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_253320832.1"
                     /sec_met_domain="PF00561 (E-value: 7.7e-22, bitscore: 77.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRFPVLALSVVTLLTTTAIASADPPDPLAEFHAQPVKWAPCSGK
                     LAELECTTLVAPLDYAKPGGDRINLTVSRRKAAAADRRRGVLFTNPGGPGGSGLGLPLF
                     LMKSELAQVYDLIGIDPRGVGGSTALNCRSAPAIAAPESRPADGEFGKWAAEAREAEEA
                     CQTSGGGIRQFISTANTARDMDVVRAVLGEAKINYLGYSYGTYLGAVYGTMFPGRLDRS
                     VLDSAVHPEWIWHEQFRQQAIAYRQDVEAWAAWVGERAEKFGLGKSRDEVLAEVEKVAV
                     KLRATPVGEYDQSSFDGAVGVGARYRPLWSDLASIVTKLRSGEQPANAEGAKAGQVLTR
                     TGLQELRSGVFDTVTCESDWPTDLHVYYEDMRMFRERYPYGFGIVRAAPMTCTFRAFTP
                     PEAPVKLAREGYPIGVVVQSEGDTQTQYAGGPAMARRLGHNLITVTDEGKHGLYNGGNK
                     CVDDKVNRYLVDGALPGSSSECAGDPRPDVPKDGQGGSALTLSPEGIQAYLDGRGFSAR
                     P"
     aSDomain        complement(2645..3205)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS23175_Abhydrolase_1.1"
                     /evalue="2.20E-17"
                     /label="ND450_RS23175_Abhydrolase_1.1"
                     /locus_tag="ND450_RS23175"
                     /protein_end="274"
                     /protein_start="87"
                     /score="55.4"
                     /tool="antismash"
                     /translation="FTNPGGPGGSGLGLPLFLMKSELAQVYDLIGIDPRGVGGSTALNC
                     RSAPAIAAPESRPADGEFGKWAAEAREAEEACQTSGGGIRQFISTANTARDMDVVRAVL
                     GEAKINYLGYSYGTYLGAVYGTMFPGRLDRSVLDSAVHPEWIWHEQFRQQAIAYRQDVE
                     AWAAWVGERAEKFGLGKSRDEVLA"
     gene            3588..4787
                     /locus_tag="ND450_RS23180"
                     /old_locus_tag="ND450_23180"
     CDS             3588..4787
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005451668.1"
                     /locus_tag="ND450_RS23180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23180"
                     /product="CdaR family transcriptional regulator"
                     /protein_id="WP_089922406.1"
                     /transl_table=11
                     /translation="MTSSKAKEEHPPTLSARTMRKIERASGSLATASVSEMERRLPWFA
                     RMPADQRASVLLLIQNGVAGFCEWLHDRQQAIRLTADAFRSAPKDISRWVSLRQTVELV
                     RIALELFEGQLPEMAADDAERALLMEGVLRYGREIAFSAATSYAAAAEARGAWDARLEA
                     LVVDGIVRGDPEESLLSRAAALGWDPALEATVLVGNPGGEDPPAIIYSVRSKAARAGRP
                     VLLSVQGSRLVVVLGGPTETGEDVLGRIAEGFGEGPVVAGPTVASLSEAHRSASDALSG
                     LRAVVGWPAAPRPVRSLDLLPERALAGDPEAEWQLVDRVARPLEDAGGALLETVDAFLE
                     VGGVLETCAKRLFVHPNTVRYRLRRVQEMTGRNAHDARDALVLRVALSVGRLARSRGLW
                     "
     misc_feature    complement(4797..4812)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.6"
                     /tool="antismash"
     misc_feature    complement(4829..4843)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
     misc_feature    4897..4913
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.9"
                     /tool="antismash"
     gene            4982..5911
                     /locus_tag="ND450_RS23185"
                     /old_locus_tag="ND450_23185"
     CDS             4982..5911
                     /EC_number="2.3.1.39"
                     /GO_function="GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_AT (6-285). E-value: 2.3e-44. Score:
                     143.9. Matches aSDomain:
                     nrpspksdomains_ND450_RS23185_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010231567.1"
                     /locus_tag="ND450_RS23185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23185"
                     /product="ACP S-malonyltransferase"
                     /protein_id="WP_253320833.1"
                     /sec_met_domain="PKS_AT (E-value: 3.5e-42, bitscore: 143.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIALLAPGQGSQTPGMLTPWLELEGAEKQVRTWSEITGLDLVRLG
                     TTAEADEIVDTAITQPLVVALAVLAFGELRKRVELPSAVIVGGHSVGELAAAAVAGVIS
                     ADDAVALAAVRGAAMAQACALEPTGMAAVLGGDEPEVLARLEELGLVPANRNGAGQIVA
                     AGPHSALDALVENPPGPAKIRKLAVAGAFHTKYMAPAEDAVRARAAEVTTQDPSLPLVS
                     NKDGQLVTEGAEVLSRLVTQVTSPVRWDLCQATFVEKGVAGSLELPPAGVLTGLAKRAM
                     KGTATLALKTPDQLEKVSELIETVGADK"
     CDS_motif       5000..5032
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS23185_0001"
                     /evalue="3.70E-03"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="ND450_RS23185"
                     /protein_end="17"
                     /protein_start="6"
                     /score="10.4"
                     /tool="antismash"
                     /translation="PGQGSQTPGML"
     aSDomain        5000..5836
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS23185_PKS_AT.1"
                     /evalue="2.30E-44"
                     /label="ND450_RS23185_PKS_AT.1"
                     /locus_tag="ND450_RS23185"
                     /protein_end="285"
                     /protein_start="6"
                     /score="143.9"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="PGQGSQTPGMLTPWLELEGAEKQVRTWSEITGLDLVRLGTTAEAD
                     EIVDTAITQPLVVALAVLAFGELRKRVELPSAVIVGGHSVGELAAAAVAGVISADDAVA
                     LAAVRGAAMAQACALEPTGMAAVLGGDEPEVLARLEELGLVPANRNGAGQIVAAGPHSA
                     LDALVENPPGPAKIRKLAVAGAFHTKYMAPAEDAVRARAAEVTTQDPSLPLVSNKDGQL
                     VTEGAEVLSRLVTQVTSPVRWDLCQATFVEKGVAGSLELPPAGVLTGLAKRAMKGTA"
     CDS_motif       5240..5341
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ND450_RS23185_0002"
                     /evalue="9.00E-14"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ND450_RS23185"
                     /protein_end="120"
                     /protein_start="86"
                     /score="43.5"
                     /tool="antismash"
                     /translation="GGHSVGELAAAAVAGVISADDAVALAAVRGAAMA"
     gene            5908..6885
                     /locus_tag="ND450_RS23190"
                     /old_locus_tag="ND450_23190"
     CDS             5908..6885
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630476.1"
                     /locus_tag="ND450_RS23190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23190"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_253320834.1"
                     /sec_met_domain="fabH (E-value: 6.4e-102, bitscore: 340.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTFQAPQAAAGSRIIGLGSYQPETVVSNHDLAARMDTSDEWIRE
                     RVGIVNRRVAAKDEGVVDMSVLAGTKAIEDAGLTPEDIGGVIVATCTMPSTIPNAAAQV
                     ATRLGIKAAAAFDLNAACAGFCYAVATAADIVRAGTVKNFLVIGAEKLTDWTHQDDRST
                     AIIFADGAGAVVVGAGETNEIGPVAWGSDGSMSEVIRIDDRDSFIHQEGQTVFRWATTQ
                     IAPVALRAAELAGVELSDVDVFAPHQANLRIIEAIAKRLHKNGAREDLKIARDIVESGN
                     TSSASIPMALDHMRSAGEISSGDVVLMVGFGAGLSYAGQVVRCP"
     gene            6920..7156
                     /locus_tag="ND450_RS23195"
                     /old_locus_tag="ND450_23195"
     CDS             6920..7156
                     /NRPS_PKS="Domain: PP-binding (8-74). E-value: 4.7e-19.
                     Score: 60.5. Matches aSDomain:
                     nrpspksdomains_ND450_RS23195_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657583.1"
                     /locus_tag="ND450_RS23195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23195"
                     /product="acyl carrier protein"
                     /protein_id="WP_030465146.1"
                     /sec_met_domain="PP-binding (E-value: 3.5e-17, bitscore:
                     61.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.013, bitscore:
                     14.8, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDNVLSGLAEIVEEVAGVAADDVTAEKSFVDDLDIDSLSMVEIA
                     VQAEDKFGVKIPDDELANLKTVGDAVNYITSNK"
     aSDomain        6944..7141
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS23195_PP-binding.1"
                     /evalue="4.70E-19"
                     /label="ND450_RS23195_PP-binding.1"
                     /locus_tag="ND450_RS23195"
                     /protein_end="74"
                     /protein_start="8"
                     /score="60.5"
                     /tool="antismash"
                     /translation="LAEIVEEVAGVAADDVTAEKSFVDDLDIDSLSMVEIAVQAEDKFG
                     VKIPDDELANLKTVGDAVNYI"
     gene            7153..8388
                     /gene="fabF"
                     /locus_tag="ND450_RS23200"
                     /old_locus_tag="ND450_23200"
     CDS             7153..8388
                     /EC_number="2.3.1.179"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (7-406). E-value:
                     3.9e-48. Score: 156.3. Matches aSDomain:
                     nrpspksdomains_ND450_RS23200_PKS_KS.1"
                     /codon_start=1
                     /gene="fabF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683048.1"
                     /locus_tag="ND450_RS23200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23200"
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="WP_253320835.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.1e-59, bitscore:
                     201.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="FabF (E-value: 5.3e-171, bitscore: 567.9,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSGIEVVITGLGATTPLGGDVTSTWDALLAGKSGVRPMTHDWVE
                     KYDLPVKIASQLVVDPTEVLPRVEARRLDRSEQVAIVASRQAWSDAGHDDDTVDRQRLA
                     VIIGTGIGGAITLLTQDDLLEQQGLRKVSPLTVPMLMPNGPAAHVGLELKAQAGVHAPV
                     SACASGAEAIAWAYRMIKSGEADVVVAGGAEACITAIPVAGFSQARTMSTRNDEPEKAS
                     RPFDTGRDGFVLGEGAGVMVLERREFAEARGAKIYGKLAGIGTSADGYHITAPDPEGVG
                     QSRAIAASLRSGGIDPADVGHVNCHATSTPVGDVAETVAIRKAIGDHPVLTAPKGALGH
                     LLGAAGAVEAIVTVLSIRDGIVPQTLNLENLDPAVTLDVVAGEPRKIKLEAAVNDSFGF
                     GGHNVALAFTPA"
     aSDomain        7174..8370
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ND450_RS23200_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.90E-48"
                     /label="ND450_RS23200_PKS_KS.1"
                     /locus_tag="ND450_RS23200"
                     /protein_end="406"
                     /protein_start="7"
                     /score="156.3"
                     /tool="antismash"
                     /translation="VITGLGATTPLGGDVTSTWDALLAGKSGVRPMTHDWVEKYDLPVK
                     IASQLVVDPTEVLPRVEARRLDRSEQVAIVASRQAWSDAGHDDDTVDRQRLAVIIGTGI
                     GGAITLLTQDDLLEQQGLRKVSPLTVPMLMPNGPAAHVGLELKAQAGVHAPVSACASGA
                     EAIAWAYRMIKSGEADVVVAGGAEACITAIPVAGFSQARTMSTRNDEPEKASRPFDTGR
                     DGFVLGEGAGVMVLERREFAEARGAKIYGKLAGIGTSADGYHITAPDPEGVGQSRAIAA
                     SLRSGGIDPADVGHVNCHATSTPVGDVAETVAIRKAIGDHPVLTAPKGALGHLLGAAGA
                     VEAIVTVLSIRDGIVPQTLNLENLDPAVTLDVVAGEPRKIKLEAAVNDSFGFGGHNVAL
                     "
     gene            complement(8826..9395)
                     /locus_tag="ND450_RS23205"
                     /old_locus_tag="ND450_23205"
     CDS             complement(8826..9395)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ND450_RS23205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ND450_23205"
                     /product="hypothetical protein"
                     /protein_id="WP_253320836.1"
                     /transl_table=11
                     /translation="MGSVASRWLVPAVVVITGAAVAAGMVGRTVYARPAEAKGTPAVES
                     SVVGTLPGSAEVRLSPDSFTHPDRTSVQRVLQEYFDAINAGDFVSWRGVVSARRVSGTP
                     EASWVSAYETTRDGGMVVQRIESDVVGRRLRVLLSFVSTQDVAKAPPALPEGCIRWRVV
                     YVLVWEGGELKVDEAAENRNPQMEKC"
     misc_feature    9455..9471
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.86"
                     /tool="antismash"
     misc_feature    complement(9463..9472)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    9473..9486
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.92"
                     /tool="antismash"
     misc_feature    9535..9548
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.19"
                     /tool="antismash"
     misc_feature    9794..9809
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    complement(9806..9815)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     gene            10001..12565
                     /gene="lanKC"
                     /locus_tag="ND450_RS23210"
                     /old_locus_tag="ND450_23210"
     CDS             10001..12565
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642932.1"
                     /locus_tag="ND450_RS23210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23210"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_253320837.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1058.2,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.5e-14, bitscore: 53.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 2.3e-06, bitscore: 26.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.5e-13, bitscore:
                     48.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYEAYCFADRQFYDLQSSTETTPADDFSLELPALPPGWTTVE
                     RNVWRHHHPNGVELPRQGWKIHVSAGLDNAGRVLKATFDHCVERRVPFKYLQTVSIVLA
                     RNSKYAPRDGSGKLITIYPADAEQLETLCTELAQVLDGEHGAYILSDLRVGKGPLYVRY
                     GGFAEQWLEIDGRQVLAIEGPDGELVADTRKPVFSLPEWIELPAFLEPHLAERNAGDAD
                     RFPYQIRSSLHFSNGGGVYLATRKSDGKEVVLKEARPHAGLDREGRDAVARLELEHEIL
                     TKLHGIDGVPEVYDRFTEWEHLFVAMEFMPGRSLGQWLGHNYPLTHKDTTPELLENYRT
                     RAQELITKIERLVEKVHERGVVFGDLHTMNILVDEDDTVSLIDFELSSTIEDVHRPTLG
                     APGFQAPKDREGFDIDAYPLAALKLWIFLPLNAVLELAPAKLRQHVHVIADRFGLGDDY
                     QRQILDVLTPRVDPPADPAFTSFDDENPDWSVVRKEIAAAILHSATPHRTDRLFPGDIE
                     QFETGGLGFGHGAAGVLHALAESGEGRYPEHEEWLVEAVRTDPPQQPGFFAGAHGIAHV
                     LENFGHHDLATEIVERYAPLVRTTRDHGLGAGLSGIGLNLLHFANERGDQNFTTQAEEL
                     AERLAKQLSEAPPPGDTARAGLLHGWSGPALFFLRLFEQTGHERWLDLSEQALERDLAE
                     TMVALDGSLQVRDGTFRSLPYVGIGGAGIALVLTEFAKAAPERPCAARLPELLDGCTGE
                     FVIQPAFTLGRAGLMATLAHATRHRPDERLERSVQRHLKALGWHAVRYGGGLAFPGVQL
                     RRLSMDLNTGGAGVLLAIASTVDGRPPLPFLGRAQTPARSGR"
     gene            12600..12761
                     /locus_tag="ND450_RS23215"
                     /old_locus_tag="ND450_23215"
     CDS             12600..12761
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800163.1"
                     /locus_tag="ND450_RS23215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23215"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_089922401.1"
                     /transl_table=11
                     /translation="MGFILDLQDIETPEAPSNVLAGGGHGGGGGSTTASNASLLLPCSH
                     STVSLLAC"
     CDS_motif       12600..12665
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGFILDLQDIETPEAPSNVLAG"
                     /locus_tag="ND450_RS23215_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12666..12761
                     /prepeptide="core"
                     /locus_tag="ND450_RS23215_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="8.70"
                     /molecular_weight="2650.9"
                     /monoisotopic_mass="2649.3"
                     /core_sequence="GGHGGGGGSTTASNASLLLPCSHSTVSLLAC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGFILDLQDIETPEAPSNVLAG"
                     /leader_location="[12599:12665](+)"
                     /alternative_weights="2668.9"
                     /alternative_weights="2686.9"
                     /alternative_weights="2705.0"
                     /alternative_weights="2723.0"
                     /alternative_weights="2741.0"
                     /alternative_weights="2759.0"
                     /alternative_weights="2777.0"
     gene            12905..14521
                     /locus_tag="ND450_RS23220"
                     /old_locus_tag="ND450_23220"
     CDS             12905..14521
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163360.1"
                     /locus_tag="ND450_RS23220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23220"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_253320838.1"
                     /transl_table=11
                     /translation="MAKPGDALLFSVIRRDHRPWALLLNAAVTTTGGLLLPAALADAVD
                     MALSGTFVLVTIVWLLALAAVEIIGDAIGVVLAASTTSRATAFLRRKLSRRLLTLGHPS
                     PFAAGDAVSRVTGDCGNAGGIAVTMITLVVTAVSSAGAVVALALLDWRLAAVFVLSVPL
                     AGLLIRTHMRMTADDVLTYQEVSGEVSARLLDSVSGLRTIASAGIADREADRVLEPLPR
                     LAAAGAGMWRTQARMMWRAGLLLPAVEVAVLTAAGFGVMQGRLSTGDVLAALGYAALGM
                     GIVGQMTQLTVLERTRASATRIAEVLDTPVPKRPVAKASNGVIELRNVSVEGALHDVNL
                     MIPAGMFVAVVGSSGAGKSTLAAVLGGLSAVDSGEVRGHDAVGYAFERPALLGATIGRS
                     IGYGTDADEVQVRDAAVAAQVHNVLIRLPQGYETPVADAPLSGGEAQRIGLARAIVRDP
                     DVLVLDDATASLDTVTEAEVDKALTTALPDRTRIVVTHRPATAARADFVVWMENGRIRG
                     TGSHGALWHNEHYRAVFTGGE"
     gene            14521..16239
                     /locus_tag="ND450_RS23225"
                     /old_locus_tag="ND450_23225"
     CDS             14521..16239
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658748.1"
                     /locus_tag="ND450_RS23225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23225"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_253320839.1"
                     /transl_table=11
                     /translation="MRFYLSTLAGHRRGVLVLLGWSLLEGVPAFFGGRLVGTAVDKGFA
                     AGDPLAGVLWLLVFAALAVAGALGQRQVFARLGSVVEPMRDALVARVVRGVLNDPTHRR
                     TPDASAVAMITRHVEVVRDATAGVLVQARALLVTTVAALVGLATTAAALIWLVVLPIVA
                     ALVLFGLMLPSLAQRQRDAVIADERTAEASGAVLSGLRDVAACHASSEAYRDIATQVDL
                     QARAAVTVAWANSLRATVIALGGFAPVALLVAFAPPLVASGQLTTGAVLAAVVYLTTSV
                     NPALHGLASTTSTVVMRLMVALKRLQEAAPRTDVQTGSESPATSEFVLRDVTFGWSPDA
                     EPVVRGLSLDLRPGDHLAVVGPSGIGKSTMAGLLTGLMPPDHGHVLFGGAPVHRVTPAI
                     RHHAIALIPQETYLFTGTVRENLALLAPWATDDELVDAAKKVGAERLLDRIGGLDGTLG
                     HGGEGLSAGEAQLLALARVYVTSAGVVVLDEATSHLDPAAEARVERAFAERQGVLVVIA
                     HRLSSALRANRVLVMDGGRPLLGTHEHLLRTSALYGRLMLAWDPTHRVETPLPKR"
     gene            complement(16257..16760)
                     /locus_tag="ND450_RS23230"
                     /old_locus_tag="ND450_23230"
     CDS             complement(16257..16760)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074684.1"
                     /locus_tag="ND450_RS23230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23230"
                     /product="DUF3145 domain-containing protein"
                     /protein_id="WP_089922398.1"
                     /transl_table=11
                     /translation="MSTRGSTSGVVYVHSSPSAVCPHVEWAISGTLGVRVDLRWAAQPA
                     APGQLRAECAWTGDAGTGAKLVAALRAWPMLRFEVTEEPSSGQDGERFCFAPVLGLWHA
                     RTSANGDIVVNEDQLRALAVRARGGESFAHGVDELLGAAWDDALEPFRRAGDGAPVTWL
                     HRVG"
     gene            complement(16962..18302)
                     /locus_tag="ND450_RS23235"
                     /old_locus_tag="ND450_23235"
     CDS             complement(16962..18302)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009153078.1"
                     /locus_tag="ND450_RS23235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23235"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_253320840.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.4e-43, bitscore:
                     146.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKRAASLAVLLVAVASPVATAAPTSTVYVHGTDIAAAEQAVEAA
                     GLQKLTSFRKIGVVAARGDAARISSARAKSGVTRVEIQKPIKFLGSTSHTATRGLDARN
                     SLGLTGEGVSVAVIDSGVDPTHPSFGGRIVRNLKSLCLDGTTQTNCIVPVPNFLDTDTT
                     SLGGHGTHVTGIAIGGDVQTTGGPVIRGAAPGAKGVVISTGAAILILGADAALNWVLEN
                     HRAPCGAGVPAATCPPIKVINNSYGPSGGGAFDPESVTVKLQRQLVAEGVVVVWANGND
                     GGDGSANLSNPPGVDPTPGVISVASYNDQGTGTRNGALSDFSSRGLAADSATWPDISAP
                     GENITSSCRPYLPICATGLDPQNGPGLLDLGTFNTISGTSMAAPHIAGIVAQLFQAKPS
                     ATPADIERALKSTAHKYGTGYQPAGPYTSSFDKGTGLVDVVAAVNAL"
     misc_feature    18356..18371
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    18417..18434
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            18446..19675
                     /locus_tag="ND450_RS23240"
                     /old_locus_tag="ND450_23240"
     CDS             18446..19675
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800159.1"
                     /locus_tag="ND450_RS23240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23240"
                     /product="hypothetical protein"
                     /protein_id="WP_253320841.1"
                     /transl_table=11
                     /translation="MRLIRLGAEPSAIGADVRAALTAWGAGTGVLGGVALLGVQPPDCP
                     VPLDAIVVLPKGVLVIVGVDLPDPGVKLEAPLGGQWTIDGWPLVSQDGSPNPATEAVAA
                     ATAVAQRIQAMRAEPLPVSTVVAVGPFVSQVVQPTNDLNRGVRVLHPKPSTLLSAAREL
                     ATSTVPCTADHAMKLLAILQTTGTPPESRTLLSEGFSEVSDLAAETTMLIPQAHLRQAI
                     GRKRLPGKLTWPYLAAGALLALVLVVWLVAALPGDDKPADATPAPSSAQPTTVVVDGTA
                     FVPKEMKKDQDCKTQAFGDVKAWLTANDCGVLLRATYETTVQGKQATVLVADMDVYDAP
                     SAKALHSVVVLPGSGGVHGLDGKPLENAAFANNVKGSHVTLAFAVWEGGAGDPSLDPIA
                     KQALRLPVSR"
     gene            19688..20047
                     /locus_tag="ND450_RS23245"
                     /old_locus_tag="ND450_23245"
     CDS             19688..20047
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222358.1"
                     /locus_tag="ND450_RS23245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23245"
                     /product="VOC family protein"
                     /protein_id="WP_089922395.1"
                     /transl_table=11
                     /translation="MVGQLRSVVLDCPNTSELASFYEQLLGAERLAGGTEDWEVIVANG
                     TRVAFQLAPEYEPPTFPDPRGSQQFHLDVLVEDIEEAEPKVLALGAKLLQRDNDDTFRV
                     YADPVGHTFCLVWLS"
     gene            20064..20480
                     /locus_tag="ND450_RS23250"
                     /old_locus_tag="ND450_23250"
     CDS             20064..20480
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034937.1"
                     /locus_tag="ND450_RS23250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23250"
                     /product="hypothetical protein"
                     /protein_id="WP_253320842.1"
                     /transl_table=11
                     /translation="MSQPIPFADTNFKLAVVQELMYNQNLLPRFDLREHAAAQGFTYDE
                     GSFGAVPEALAYFEALEVPAELAGKITEIYMDGGNEIYLEIAPGWDGEDGLFDVDEFAD
                     VRHFPNLKSMTLLYTGNQEALEALRARGIEADWL"
     gene            20700..22052
                     /locus_tag="ND450_RS23255"
                     /old_locus_tag="ND450_23255"
     CDS             20700..22052
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800157.1"
                     /locus_tag="ND450_RS23255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ND450_23255"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_253320843.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.2e-39, bitscore:
                     132.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFDVIVIGGGPVGENVAWRTAAGGLSTAMIEKELVGGECSYWAC
                     MPSKALLRSGHALAAAQRVKGVVGGSLDPAAVLERRTGFTSNWDDTGQVKWAESENIHV
                     LRGDGEVTGEREVTVRGADGETVYRARQAVVVCTGSVPKMPPLDGIDDTPVWTSRDATS
                     AREVPDSLVVLGGGVVGVEMAQAWARLGSQVKIVVSGDRPLPKMEDFVGPLVVEGLEAD
                     GVEVLLNGRAAAIKPGELTLQDGRTVQGSHILVATGRVPATKDGKPLTIDDSGLVSGVD
                     GRWLYAAGDVTGRALLTHQGKYQGRAVGTAILERSRGFEPKERSAGQAWADHVAVPQVV
                     FTDPEVAFVGHTAEQARAAGRDVKVVDLDIAVAGSSLHADGYKGKTRMVVDERTRTLVG
                     VTFVGQDVAELLHSATVAIVGEVTVDRLWHAVPSYPTISEVWLRLLESYGL"
     misc_feature    22240..22254
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 gcgcgcgccc tcctcgacca cgacgtcccc gatgagggtg ctctcctcgt cgacgatgcc
       61 ctggacgtcg gtgcgcagcc gttgcagcac ctcgcggttg cactccagca cgtcctcgac
      121 cttcccggtg tccttccaga accccgagta gatccgcgcc cgcacgtcgc ggtcgttcgt
      181 caccagccac tgcaacgcgt cggtgatctc gagctcgccg cgccacgacg gctcgatcgc
      241 gtccacggcc tcgtggatgc gcggggtgaa gaagtacacg ccgatcatgg cgaggtcgct
      301 gcgcggctcc tgcggcttct cgaccagccg cgtcacccgc gagttctcgt ccacctcggc
      361 gacgccgaac gcgcgcgggt ccggcacctt gtagacgacg acctgagcgg acgtccggtt
      421 cgccgcgaac tcgtcggcga tctcggagat cccctcgacg agcatgttgt cgcccaggta
      481 catcacgaag tcgtcgtcgc cgaggaacgg ccgcgcgatc ttcacgcagt gcgcgagccc
      541 gagcggcgcg tcctgcggga tgtacgtgat cgccacgccc agggcggatc cgtcgcccag
      601 cacgtcggag atctcgtgag cgcggtcgcc gacgatgatg ccgatctcgg tgatcccgat
      661 ctcgcgcagg ttgtcgacca cgtactcgag gacgggcttg ttggcgatcg ggatcagttg
      721 tttcggcatc gagtagctga atggtcgcag gcgtgttccc gcgcctccgg acagcaccag
      781 ggctttcatg gaacgtctcc tccaccgtca cgtggaaccg aggttcgccg cccctggtag
      841 accgcaactg gagaacgacc taaaacgcga agaagggccc gcgctgctcc agcgcgggcc
      901 cttccgtcga gatcagacct accggtcggt catcggcatg cccgacggag gcgtcggcgc
      961 gtcacccatg cgggcaccga cgttctgcgg catctcctgc gacgcgcgcg gcatcgggga
     1021 ctgggcctgg gcctcgtcct gcgcgcgggc cagccagccc tcccagcgct gctgcatcgg
     1081 gcggaccagg ccgccgccga caccgatgac gatcacgccg gcgacggtcg cgagcaccgc
     1141 gatgagaacc ggcatggtca ccgagacggc gatgcccagc tggttgagcg ccgcgatgat
     1201 gccgagcgcc atcacgaagc cgtaggtgat gttgcccatg agcttcgtgt acgaccgctg
     1261 gccgagcgcg ccggtcacga gacccttgag ggcggtgccg atcgcggacg cgacgatcac
     1321 gagcaccagc gcgacgacga tgcgcggcag gtacgcgatg acctcgttga gcagcgtgct
     1381 gaccgggttc gaggcgccga agacgccgaa cgccagctgc agcgcgatga gcagcacgaa
     1441 atagtacacg atcttggaga tcagaccgga ggcgtccatc gacgactgcc gcatcgcgcc
     1501 gttgaggccc gacctgtcga ccagcttttc gaagccgacg cgcttgagca ggaactggac
     1561 gcccttggcc agtgccttgg cgatgaacca gccgatgagc agcacgacga ggaagccgag
     1621 cagcttcggc acgaacgtgg cgatcatcgc ccacgcctgg cccaggccct cggtgatttg
     1681 cgagcccacg ggccctccta gaacaaaagt tgcggtgagt gaagatccga ccgtctgatc
     1741 gtttcgcgga tcacaccgcc gttcaacttc gacactgcta cacgaaaggg tggctgacgt
     1801 ggatttttgt ctcaatacag tccagagtgg aaggaccggt ggggaccggg gagagggaag
     1861 ggcccgccac gctccgtggc gggcccttcc acattcctcc cgccggtcgc tagggccgcg
     1921 cggagaaccc gcggccgtcc aggtaggcct ggatgccctc cggtgacaac gtcagcgccg
     1981 agccgccctg cccgtccttc ggcacgtccg gccgcgggtc gccggcgcac tcggaactgc
     2041 tgcccggcag cgccccgtcg acgaggtacc ggttgacctt gtcgtccacg cacttgttgc
     2101 cgccgttgta gaggccgtgc ttgccctcgt cggtgacggt gatcaggttg tgcccgagcc
     2161 gccgcgccat cgccgggccg cccgcgtact gggtctgcgt gtcgccctcg gactgcacga
     2221 cgacgccgat cgggtagccc tcgcgcgcga gcttgaccgg cgcctccggc ggcgtgaacg
     2281 cgcggaacgt gcacgtcatg ggcgcggccc gcacgatccc gaagccgtac gggtagcgct
     2341 cgcggaacat ccgcatgtcc tcgtagtaga cgtgcaggtc cgtcggccag tccgactcgc
     2401 aggtgaccgt gtcgaacacg ccggagcgca gttcctgcaa cccggtcctc gtgagcacct
     2461 gcccggcctt ggcgccctcg gcgttcgcgg gctgctcccc cgaccgcagc ttggtcacga
     2521 tcgacgccag gtccgaccac agtggacggt agcgggcgcc gacgcccacc gcgccgtcga
     2581 aggaggactg gtcgtactcg ccgaccggcg tggcgcgcag cttcaccgcg accttctcga
     2641 cctcggcgag cacctcgtcc cgcgacttgc cgagcccgaa cttctcggcg cgctccccca
     2701 cccacgccgc ccacgcctcg acgtcctgcc ggtaggcgat ggcctgctgg cggaactgct
     2761 cgtgccagat ccactccggg tgcaccgcgg agtcgagcac gctgcggtcg agccggcccg
     2821 ggaacatcgt cccgtacacc gccccgaggt acgtgccgta ggagtagccc aggtagttga
     2881 tcttcgcttc gccgaggacg gcccgcacga cgtccatgtc ccgcgcggtg ttggcggtgc
     2941 tgatgaactg ccggatcccg ccgcccgagg tctggcaggc ctcctcggcc tcgcgggcct
     3001 cggccgccca cttgccgaac tcgccgtccg cgggccggga ctcgggcgcg gcgatcgcgg
     3061 gcgcgctgcg gcagttcagc gccgtcgagc cgccgacgcc gcgcgggtcg atgccgatca
     3121 ggtcgtagac ctgcgcgagc tcggacttca tcaggaacag cggcagcccg agccccgaac
     3181 cgccaggtcc acccggattg gtgaacagca caccgcgcct gcggtcggcg gccgcggcct
     3241 tcctgcggct gaccgtcagg ttgatcctgt ccccgcccgg tttcgcgtag tcgagcggcg
     3301 cgacgagcgt ggtgcactcc agttcggcga gttttccgct gcacggcgcc cacttgaccg
     3361 gttgcgcgtg gaactcggcg agggggtcgg gaggatcggc cgaggcgatc gcagtcgtcg
     3421 tcagcagggt caccacgctc agggcgagta ccgggaacct gtgcaagatc gaacctccgc
     3481 gccggaccga aagatctctg ctgcccgaag gtatgggggt tcacacgggt ccatgggttg
     3541 tgtcacccgt accggtgatg gggcccgact ggccctaagc tgcgggtatg accagcagca
     3601 aggcgaagga ggagcacccg ccgacgctct ccgcccgcac catgcgcaag atcgaacgcg
     3661 cgtcgggctc gctcgcgacc gccagcgtgt ccgagatgga gcggcggctg ccgtggttcg
     3721 cccggatgcc cgcggaccag cgggcgagcg tcctgctgct gatccagaac ggcgtcgcgg
     3781 ggttctgcga gtggctgcac gaccggcagc aggcgatccg gctgacggcg gacgcgttcc
     3841 gcagcgcccc caaggacatc tcccgctggg tcagcctgcg gcagaccgtc gagctggtca
     3901 ggatcgcgct ggagctgttc gaggggcagc tgccggagat ggcggccgac gacgccgagc
     3961 gcgcgctgct gatggagggc gtgctgcggt acgggcggga gatcgcgttc tccgccgcca
     4021 cctcctacgc ggcggccgcc gaggcgcgcg gcgcgtggga cgcccgcctg gaggcgctgg
     4081 tcgtcgacgg catcgtgcgt ggcgaccccg aggagtcgct gctctcccgc gcggcggcgc
     4141 tgggctggga ccccgcgctg gaggcgacgg tgctggtcgg caatcccggc ggcgaggacc
     4201 cgcccgcgat catctactcg gtgcgcagca aggcggcccg cgccgggcgg ccggtgctgc
     4261 tgtccgtgca gggctcgcgg ctggtcgtcg tgctcggcgg gccgacggag accggggagg
     4321 acgtgctggg gcgcatcgcc gagggcttcg gcgaggggcc ggtcgtcgcg ggcccgacgg
     4381 tggccagcct gtccgaggcc caccgcagcg ccagtgacgc gctgagcggc ctgcgcgccg
     4441 tggtcggctg gcccgccgcg ccccggcccg tccggtcgct cgacctgctg ccggaacggg
     4501 cgctggcagg cgacccggag gccgagtggc agctggtgga ccgggtcgcc cggccgctgg
     4561 aggacgcggg cggcgcgctg ctggagaccg tggacgcgtt cctggaggtc gggggcgtgc
     4621 tggagacgtg cgcgaaaaga ctgttcgtgc acccgaacac ggtcagatat cgccttcggc
     4681 gcgttcagga aatgacggga agaaatgcac atgacgctcg agacgcgctt gtgcttcgcg
     4741 tcgcattgtc tgtaggacgc ctagcgcgct cccggggcct gtggtagcga acggcctgtg
     4801 acggacttcg cacacagccg ttggggtgag ggccgaacga ccctgtatag cgctgagctg
     4861 gggttacgtc gcgcagcgtt cacctgggag tcacttttgt agggtctcta caaatacgat
     4921 cgccgtactt cgttcttcac gacatggggt accagtgggt tcaccggctt tagtaatcga
     4981 cgtgatcgca ctcctcgcgc ccggacaagg gtcccagacg cccggcatgc tcaccccctg
     5041 gctcgaactg gagggggcgg agaagcaggt ccggacgtgg tcggagatca cgggcctgga
     5101 cctggtgcgc ctcggcacca ccgcggaggc cgacgagatc gtcgacaccg cgatcaccca
     5161 gccgctggtc gtggctctcg ccgtgctcgc gttcggtgag ctgcgcaagc gcgtggaact
     5221 gccctccgcc gtgatcgtcg gcggccactc ggtcggcgag ctcgccgcgg ccgccgtcgc
     5281 gggcgtcatc agcgccgacg acgccgtcgc gctggccgcc gtgcgcggtg ccgcgatggc
     5341 gcaggcgtgc gccctggagc cgaccggcat ggccgcggtg ctcggcggtg acgagccgga
     5401 ggtgctcgcg cgcctcgagg agctcggtct cgtgcccgcg aaccgcaacg gcgcgggcca
     5461 gatcgtcgcg gccggtccgc actccgcgct cgacgcgctc gtcgagaacc cgcccggccc
     5521 ggcgaagatc cgcaagctgg ccgtcgcggg cgcgttccac accaagtaca tggcgcccgc
     5581 ggaagacgcc gtgcgcgcgc gtgccgccga agtgaccacg caggacccgt cgctgccgct
     5641 ggtgtccaac aaggacggtc agctcgtcac cgagggcgcc gaggtgctgt cgcgcctggt
     5701 cacccaggtc acgagccccg tccgctggga cctctgccag gccaccttcg tcgagaaggg
     5761 tgtcgcgggc tcgctcgaac tgccgcccgc cggcgtgctg acgggtctcg ccaagcgtgc
     5821 gatgaagggc accgcgaccc tcgccctgaa gacccccgac cagctggaga aggtctcgga
     5881 gctcatcgag accgttggag ccgataagtg acgaccttcc aggccccgca ggcagccgcg
     5941 ggtagccgca tcatcgggct cggcagctac cagcccgaga ccgtcgtgag caaccacgac
     6001 ctcgccgcgc gcatggacac ctcggacgag tggatccgcg agcgcgtcgg catcgtgaac
     6061 cgccgcgtgg ccgcgaagga cgagggtgtc gtcgacatgt ccgtcctcgc gggcaccaag
     6121 gcgatcgagg acgcgggcct caccccggag gacatcggcg gcgtgatcgt ggcgacgtgc
     6181 accatgccgt cgaccatccc gaacgccgcc gcgcaggtcg ccacccgcct cggcatcaag
     6241 gccgcggccg cgttcgacct gaacgccgcg tgcgcgggct tctgctacgc cgtcgcgacg
     6301 gccgcggaca tcgtccgcgc cggcaccgtg aagaacttcc tcgtcatcgg tgccgagaag
     6361 ctcaccgact ggacccacca ggacgaccgc tcgaccgcga tcatcttcgc ggacggcgcg
     6421 ggtgccgtcg tggtcggcgc cggtgagacg aacgagatcg gccccgtcgc gtggggctcg
     6481 gacggcagca tgtccgaggt catccgcatc gacgaccgcg actcgttcat ccaccaggag
     6541 ggccagacgg tcttccggtg ggccacgacc cagatcgccc cggtggcgct gcgcgccgcc
     6601 gagctcgcgg gtgtcgaact gtccgacgtg gacgtgttcg ccccgcacca ggccaacctc
     6661 aggatcatcg aggccatcgc caagcgcctg cacaagaatg gtgcgcgcga ggacctgaag
     6721 atcgctcgag acatcgtcga atccggcaac acctcctcgg cctcgatccc catggcactg
     6781 gaccacatga ggtcggcagg cgagatctcc tcgggagatg tcgtgctgat ggtcggtttc
     6841 ggcgcgggcc tgtcctacgc gggacaggtg gtccggtgcc catgagttct tccaccgttt
     6901 caatcgaaag ggaacttcag tgagcgacaa cgtcctgtcc ggtcttgccg agatcgtcga
     6961 agaggtcgcc ggcgttgccg ccgacgacgt caccgctgag aagtccttcg tggacgacct
     7021 cgacatcgac tcgctgtcga tggtcgagat cgccgtccag gctgaggaca agttcggcgt
     7081 gaagatcccg gacgacgagc tggccaacct caagaccgtt ggtgacgcgg tgaactacat
     7141 caccagcaac aagtgacttc gggcatcgag gtcgtcatca ccgggctggg tgccaccacc
     7201 ccgctcggtg gtgatgtcac gtccacctgg gacgcgctgc tggccggcaa gagcggggtt
     7261 cgccccatga cccacgactg ggtcgagaag tacgacctgc cggtcaagat cgcgtcgcag
     7321 ctcgtggtgg acccgaccga ggtgctcccc cgagtcgagg cacgccgcct ggaccgctcc
     7381 gagcaggtcg ccatcgtggc gtcccgccag gcgtggtccg acgcgggcca cgacgacgac
     7441 accgtcgacc gccagcgcct cgccgtcatc atcggcaccg gcatcggcgg cgcgatcacc
     7501 ctcctgaccc aggacgacct cctggagcag cagggcctgc gcaaggtgtc gccgctgacc
     7561 gtcccgatgc tgatgccgaa cggcccggcc gcccacgtcg gcctggagct caaggcacag
     7621 gcgggcgtgc acgccccggt ctccgcctgc gcgtcgggcg ccgaggccat cgcctgggcc
     7681 taccgcatga tcaagtccgg cgaagccgac gtggtcgtag cgggcggcgc cgaagcgtgc
     7741 atcacggcca tcccggtggc gggcttctcg caggcccgca ccatgagcac ccgcaacgac
     7801 gagccggaga aggcctcacg cccgttcgac acgggccgcg acggcttcgt cctcggcgag
     7861 ggcgcgggcg tcatggtcct ggaacgccgg gagttcgccg aggcccgcgg cgcgaagatc
     7921 tacggcaagc tcgccggcat cggcacctcg gccgacggct accacatcac cgccccggac
     7981 cccgagggcg tgggccagtc ccgtgccatc gcggcgtccc tgcgctcggg cggcatcgac
     8041 ccggccgacg tgggccacgt gaactgccac gcgacctcca ccccggtggg cgacgtcgcg
     8101 gagaccgtgg cgatccgcaa ggcgatcggc gaccacccgg tcctgaccgc gccgaagggc
     8161 gcactgggcc acctgctggg cgcagcggga gcggtagagg ccatcgtcac cgtcctctcg
     8221 atccgcgacg gcatcgttcc ccagacgctc aacctggaga acctcgaccc ggccgtcacg
     8281 ctggacgtgg tggcgggcga accccgcaag atcaagctgg aggccgccgt gaacgactcg
     8341 ttcggcttcg gcggccacaa cgtggcgctg gccttcaccc cggcctagcc cacacgctcc
     8401 accgcacgcc ccggtctgct ccgcagaccg gggcgttgtg ctgtgcgggg aaaggcggcg
     8461 gggcgcgggg ccgggaggcg ggagaggcac ggcaggcgag cggtgggatc ggtgcgatgc
     8521 cggaggcgag ccgtctttgg caaagaggaa ccggcggtgg ggtcccatca cgagtcgcgc
     8581 cacagctctt gctgcacctg aggcccgctc ttggtgcggc ttgggatggg accccaccgc
     8641 caccgcaacc aaaccaagca acaggcagcc gctctaagtg gcaggcgtgc catctacctg
     8701 cccgcggcgc taccccctga tcagattgcc ggggtctggg gcagagcccc aggggaagca
     8761 cgcaacagca acaggccgcc cgcaacccca accacccgca caagccgcga acccgcgacc
     8821 aaagctcagc acttctccat ctgggggttc cggttctccg cagcctcgtc caccttcaac
     8881 tccccaccct cccacaccag cacgtacacc acccgccacc gaatgcaccc ctccggcaac
     8941 gcgggcggcg ccttcgcaac gtcctgagtg gacacaaaag acaacagcac ccgaagccgc
     9001 cgccccacca cgtccgactc gatccgctgc accaccatcc cgccgtcacg agtggtctcg
     9061 tacgccgaca cccagctcgc ctcgggcgtc ccggacaccc gccgggccga caccacccca
     9121 cgccacgaga cgaagtcccc ggcgttgatc gcgtcgaagt actcctgcag cacccgctgc
     9181 accgaggtcc ggtccgggtg ggtgaaggag tccgggctca gccgcacctc cgcggacccc
     9241 ggcagcgtgc ccacgaccga cgactcgacc gccggtgtgc ccttggcctc ggccgggcgg
     9301 gcgtacacgg tccggcccac cattccggcc gccaccgcgg ctccggtgat caccaccacg
     9361 gccggcacca gccagcggct cgccacgctc cccacggccg ccagcctagt cgcacgacac
     9421 gccgagcagc agagggccac tcacgaaaca ggtcgcgtta catcaaaaca caatttttca
     9481 ctcgaacgat tacatcacac cggaatttac tcagttgcat gtagtaagac aatgtttggt
     9541 acataaaagt caatgggcaa tctcctccta cgaatgggtt ccaacggggc actcaatacc
     9601 gccattcggc cgcatcaaac acgcaattgc agccaatcaa ggcttcaccc ggagagagca
     9661 gtcgccactg cgcgtgcacg acacatcacc gcatccacct atacgtcgga cacgatttgg
     9721 aatagcgcag ctcagaggcg cctcagaagc gagacgtcag agttccgttt agcggcgacc
     9781 ccgacaaaac ccgtccaccg gctggtcaac aaacatctca accgggtgag atggacccaa
     9841 acctcatcac gacgcgtcac atacgcatcg gtaaccgaca ctctttcagc cacgaacagg
     9901 ggacccatat gactctaacg gcggattccc catagctgcg gatttgtgcg ggaatatgcc
     9961 gcgtcaaaca aaacgcaaac gagtcggaga ggggaattcg gtggacctca gatacgaggc
    10021 gtactgcttc gcggaccggc agttctacga tctgcagagc agcaccgaaa ccactcccgc
    10081 ggacgacttc tcgctcgaac tccccgcact tccgcccggc tggacgaccg tcgagcgcaa
    10141 cgtgtggagg caccaccacc cgaacggtgt ggagctcccc cggcaggggt ggaagatcca
    10201 cgtctccgcc ggtctcgaca acgccggccg ggtgctgaag gcgaccttcg accactgcgt
    10261 cgagcggcgc gtccccttca agtacctgca gaccgtctcg atcgtgctgg cccgcaactc
    10321 gaagtacgcc ccgcgcgacg gcagcggcaa gctcatcacg atctacccgg cggacgccga
    10381 gcagctcgag accctctgca ccgagctcgc gcaggtcctc gacggtgagc acggggccta
    10441 catcctgagc gacctccgcg tcggcaaggg tccgctctac gtccgctacg gcgggttcgc
    10501 cgagcagtgg ctggagatcg acggccggca ggtgctcgcg atcgagggcc cggacggcga
    10561 actggtggcg gacacgcgca agccggtgtt cagcctcccc gagtggatcg agctgcccgc
    10621 cttcctcgag ccgcacctcg ccgagcgcaa cgcgggcgac gcggacaggt tcccgtacca
    10681 gatcaggagt tcgctgcact tctccaacgg cggcggcgtc tacctcgcga ctcgcaagag
    10741 cgacggcaag gaggtcgtgc tcaaggaggc gcggccgcac gccgggctcg accgcgaggg
    10801 ccgcgacgcg gtggctcgtc tcgaactcga gcacgagatc ctcacgaagc tgcacggcat
    10861 cgacggcgtt cccgaggtgt acgaccgctt caccgagtgg gagcacctgt tcgtggccat
    10921 ggagttcatg ccggggcgtt cgctcgggca gtggctcggc cacaactacc cgttgacgca
    10981 caaggacacc acgcccgaac tcctcgagaa ctaccgcacc agggcacagg agctcatcac
    11041 caagatcgag cgcctcgtcg agaaggtgca cgagcgcggc gtcgtcttcg gcgacctgca
    11101 cacgatgaac atcctggtcg acgaggacga caccgtctcg ctcatcgact tcgagctctc
    11161 ctcgaccatc gaggacgtgc accgcccgac gctcggcgcg cccggtttcc aggcgcccaa
    11221 ggaccgcgag ggcttcgaca tcgacgccta cccgctggcc gcgctcaagt tgtggatctt
    11281 cctgccgctc aacgcggtgc tggagctcgc gccggccaag ctgcgccagc acgtccacgt
    11341 catcgcggac cggttcggcc tgggcgacga ctaccagcgg cagatcctcg acgtgctcac
    11401 cccgcgcgtc gacccgccgg ccgatcccgc gttcacctcg ttcgacgacg agaacccgga
    11461 ctggtcggtg gtgcgcaagg agatcgccgc cgcgatcctg cacagcgcga cgccgcaccg
    11521 caccgaccgc ctgttccccg gcgacatcga gcagttcgag accggcggcc tcggcttcgg
    11581 ccacggtgcc gcgggtgtgc tgcacgcgct cgcggagagc ggcgagggcc gctaccccga
    11641 gcacgaggag tggctcgtcg aggcggtccg caccgacccg ccccagcagc ccggcttctt
    11701 cgccggcgcc cacggcatcg cgcacgtgct ggagaacttc ggccaccacg acctcgcgac
    11761 cgagatcgtc gagcgctacg ccccgctcgt ccgcaccacg agggaccacg ggctcggcgc
    11821 cggcctgtcc ggcatcggcc tcaacctgct gcacttcgcg aacgagcgcg gcgaccagaa
    11881 cttcaccacc caggccgagg agctggccga acggctcgcg aagcagctct ccgaagcccc
    11941 accgcccggc gacacggcga gggcgggcct gctgcacggc tggtccggtc ccgcgctgtt
    12001 cttcctgcgc ctgttcgagc agaccggaca cgagcgctgg ctcgacctgt ccgaacaggc
    12061 tctcgaacgc gacctggccg agacgatggt cgcactggac ggttcactgc aggtccgcga
    12121 cgggacgttc cgaagcctgc cctacgtcgg catcggcggc gcgggaatcg cgctggtgct
    12181 cacggagttc gcgaaggcgg caccggaacg tccctgcgcg gcaaggcttc ccgagctgct
    12241 cgacggctgc accggcgagt tcgtcatcca gcccgcgttc acgctcggca gggcaggcct
    12301 gatggccacc ctcgcccacg cgacgaggca ccggcccgac gagcgcctcg aacgctccgt
    12361 ccagcggcac ctcaaggccc tcggctggca cgccgtgcgc tacggcggcg ggctcgcgtt
    12421 ccccggggtg cagctgcgcc ggctctccat ggacctcaac accggcggtg cgggcgtgct
    12481 gctcgccatc gcctccacag tggacggacg tccaccactc cccttcctcg gaagggccca
    12541 gaccccggcc cgctcgggcc ggtagcaaga agatcgattc ctcgaattag gagacagtca
    12601 tgggcttcat cctcgacctg caggacatcg agacccccga ggcgccgagc aacgtgctcg
    12661 cgggcggcgg ccacggtggc ggcggcggct ccacgaccgc gtccaacgcg tcgctgctgc
    12721 tcccctgctc gcacagcacc gtcagcctgc tggcctgctg acctgcgctt caactgcaac
    12781 accgcggtga gtgagcggca taggcgaagt atgccgctca ccctccgact gcagggcccg
    12841 gcagccggcc agctgtcggg ccctcgctca tgatgcgccc tgaacacccc cggaggaaca
    12901 gccgatggcc aaaccaggtg acgccctcct gttctccgtg atccgccgcg accaccgccc
    12961 gtgggcgctg ctgctcaacg ccgcggtcac cacgaccggc ggcctgctgc tccccgcagc
    13021 gctcgccgac gccgtcgaca tggccctgag cggaacgttc gtgctggtca cgatcgtgtg
    13081 gctgctcgcg ctggcggccg tcgagatcat cggtgacgcc atcggcgtcg tgctcgccgc
    13141 gagcaccacg agccgggcga cggccttcct gcgccgcaag ctgtcccggc gactcctcac
    13201 cctcggccat ccctcgccgt tcgccgccgg tgacgcggtg agccgggtga cgggcgactg
    13261 cggcaacgcg ggcggcatcg ccgtcacgat gatcaccctc gtcgtcaccg ccgtgtcctc
    13321 ggcgggcgcc gtcgtcgcgc tggcgttgct ggactggcgg ctcgcggccg tgttcgtgct
    13381 gagcgtcccg ctggcggggt tgctgatccg cacgcacatg cgcatgaccg ccgacgacgt
    13441 gctgacctac caggaggtct ccggtgaggt ctcggcacga ctgctcgact ccgtgtccgg
    13501 tctgcgcacg atcgcgtccg ccggcatcgc cgaccgggag gcggaccgcg tgctggagcc
    13561 gctgccccgg ctcgccgcgg ccggtgccgg catgtggcgc acccaggcga ggatgatgtg
    13621 gcgggccggg ctgctgctgc ccgccgtcga ggtcgcggtg ctcaccgcgg ccggtttcgg
    13681 cgtgatgcag ggcaggctga gcaccggtga cgtgctcgcc gccctcggct acgcggcact
    13741 gggcatgggg atcgtcggtc agatgaccca gctgaccgtg ctcgaacgga cccgcgccag
    13801 cgccaccagg atcgccgagg tcctcgacac cccggtgccg aagcggcctg tcgcgaaggc
    13861 gtccaacggc gtcatcgagc tgcggaacgt cagcgtcgaa ggcgcgctgc acgacgtgaa
    13921 cctgatgatc ccggccggca tgttcgtcgc ggtcgtcggc agttccggcg cgggcaagtc
    13981 gacgctggcg gcggtgctcg gcggactgtc cgctgtggac tccggcgagg tgcgcggcca
    14041 cgacgcggtc ggctacgcct tcgaacgtcc cgcgttgctg ggcgcgacga tcggccgttc
    14101 gatcggctac ggaacggacg ccgacgaggt ccaggtcagg gacgccgccg tcgccgccca
    14161 ggtgcacaac gtgctcatcc ggctgcccca gggctacgag acgccagtcg ccgacgcccc
    14221 tctgtccggc ggtgaggcgc agcggatagg cctcgcccgc gcgatcgtcc gcgatccgga
    14281 cgtgctcgtg ctcgacgacg cgaccgcgag tctggacacc gtgaccgagg ccgaagtgga
    14341 caaggcgctc accacggccc tgcccgacag gacgcggata gtggtgacgc accgcccggc
    14401 cacagccgcg agggcggatt tcgtggtgtg gatggagaac ggccggatca ggggcaccgg
    14461 cagccacggg gccctgtggc acaacgagca ctaccgagcc gtgttcaccg ggggcgagtg
    14521 atgcgcttct acctctccac gctggcagga caccgccgag gcgtgctggt cctgctcggc
    14581 tggtcgctgc tcgagggcgt tcccgcgttc ttcggcggca ggctcgtcgg caccgccgtc
    14641 gacaagggct tcgcggcggg agatccgctg gccggcgtgc tgtggctgct cgtgttcgct
    14701 gccctcgcgg tggccggcgc gctgggccag cggcaggtgt tcgcccggct cggctccgtc
    14761 gtcgaaccga tgcgcgacgc cctggtcgcg cgggtcgtgc ggggcgtgct gaacgacccg
    14821 acgcaccgcc gcaccccgga cgccagcgcg gtcgccatga tcacccggca cgtcgaggtg
    14881 gtccgcgacg ccaccgcggg cgtgctggtg caggcccgtg cgctcctggt cacgacggtg
    14941 gccgcgctgg tcggcctcgc gacgacggcc gccgcgctga tctggctggt cgtgctcccg
    15001 atcgtggccg cgctggtgct cttcgggttg atgctcccgt cgctcgccca acggcaacgc
    15061 gacgccgtga tcgccgacga acgcacggcg gaggcgtccg gcgcggtgct gagcggactg
    15121 cgcgacgtgg ccgcctgcca cgcttcctcc gaggcctacc gggacatcgc gacgcaggtc
    15181 gacctgcagg ccagggccgc ggtcaccgtc gcgtgggcca actcgttgcg cgccacggtg
    15241 atcgcgctgg gcggcttcgc gcccgtcgcg ctgctggtgg cgttcgctcc cccgctggtc
    15301 gcgtccgggc agctcacgac gggtgcggtc ctggccgcgg tcgtctacct caccaccagc
    15361 gtgaaccccg cgctgcacgg cctggccagc acgaccagca cggtcgtgat gcggctgatg
    15421 gtcgcactca aacgacttca ggaagcggca ccgcgcacgg acgtgcagac gggctcggag
    15481 agcccggcga ccagcgagtt cgtcctgcgg gacgtgacgt tcggctggag cccggacgcg
    15541 gaaccggtgg tgcgcggcct gtcgctcgac ctgcgtcccg gcgaccacct ggcggtcgtc
    15601 ggcccgtccg gcatcggcaa gtccacaatg gccggtctgc tcaccgggct gatgccaccg
    15661 gaccacggcc acgtgctgtt cggcggagcg ccggtccacc gggtgacgcc ggcgatccgg
    15721 caccacgcga tcgcgctgat cccgcaggag acgtacctgt tcaccggcac cgtgcgggag
    15781 aacctcgcgc tactcgcgcc gtgggcgacc gacgacgaac tggtcgacgc ggcgaagaag
    15841 gttggcgccg aacgacttct ggacaggatc ggcggcctgg acgggacact cggccacggc
    15901 ggcgaaggac tttccgctgg tgaggcacag cttctcgcgc tcgcacgggt ctacgtgacg
    15961 tctgcgggcg tcgtcgtcct cgacgaggcg acctcccacc tcgaccccgc cgccgaagcc
    16021 agggtcgaac gggctttcgc ggaacggcaa ggggttctcg tggtgatcgc gcaccggctg
    16081 agctcggcgc tgcgggcgaa ccgcgtgctg gtcatggacg gcggcaggcc gttgctcggc
    16141 acgcacgagc acctgctcag gacgtccgcg ctctacgggc ggctcatgct ggcctgggat
    16201 cccacgcacc gggtggaaac cccgctgccc aaacggtgag cggggtccac tcaggactag
    16261 ccgacgcggt gcagccaggt gaccggcgcg ccgtctcccg cacggcggaa cggttccagg
    16321 gcgtcgtccc acgccgcgcc gagcagctcg tcgacgccgt gcgcgaagga ctcaccgcca
    16381 cgagcccgga ccgcgagtgc acgcagctgg tcctcgttca cgacgatgtc accgttggcc
    16441 gaggttctgg catgccagag ccccagcacg ggcgcgaagc agaagcgctc cccgtcctga
    16501 ccggaggaag gttcctcggt cacctcgaac cggagcatcg gccacgcgcg cagcgcagca
    16561 acgagcttgg cgccggtgcc ggcgtctccg gtccacgcgc attcagcgcg caactggcct
    16621 ggtgctgcgg gttgcgctgc ccacctgagg tctacccgga caccgagggt gcccgagatc
    16681 gcccactcga cgtgcggaca gaccgcagac ggcgacgagt ggacgtaaac cacgccactg
    16741 gtgctgccac gggtgctcac tgctgacctc cgctactcga cgagggacgt cttcccctac
    16801 gcctttgccg agtgtgaggt gatcaccgcg aaacccgttc gctgcattct gcctcgactt
    16861 gaggcatgtc cgccataaga accagctcga tcatcacccg accggggcag atacaggtct
    16921 taagtcccga tctccccggc cgagcgatgc ctgatcgtga tctagagcgc gtttaccgcg
    16981 gccacgacgt cgaccaggcc ggttcccttg tcgaacgacg aggtgtacgg cccggccggc
    17041 tggtagcccg tgccgtactt gtgggcggtc gacttcagcg cccgctcgat gtcggcgggg
    17101 gtcgcggaag gcttggcctg gaacagctgt gcgacgatcc cggcgatgtg cggcgccgcc
    17161 atcgacgtgc cgctgatcgt gttgaacgtg ccgaggtcga gcagtcccgg cccgttctgc
    17221 gggtccaggc cggtggcgca gatcggcagg taggggcggc acgacgaggt gatgttctcc
    17281 cccggcgccg agatgtccgg ccacgtcgcg gagtccgcgg cgagaccgcg cgaggagaag
    17341 tcggacaggg cgccgttgcg ggtgccggtg ccctggtcgt tgtaggaggc gaccgagatc
    17401 acgccggggg tcgggtcgac accgggcggg ttggacaggt tcgcggaccc gtcaccaccg
    17461 tcgttgccgt tcgcccacac gacgacgaca ccttccgcga cgagctggcg ctgcagcttg
    17521 accgtcaccg actcggggtc gaacgcgccc ccgccggacg ggccgtagga gttgttgatc
    17581 accttgatcg gcgggcaggt cgccgcgggc accccggcgc cgcacggggc ccggtggttc
    17641 tccagcaccc agttcagcgc ggcgtccgcg ccgaggatga ggatcgccgc gccggtcgag
    17701 atcacgacgc ccttcgcgcc cggagcggca ccgcggatca ccgggccgcc ggtggtctgc
    17761 acgtcaccgc cgatcgcgat gccggtgacg tgggtgccgt gaccgcccaa cgacgtcgtg
    17821 tcggtgtcca ggaagttcgg caccggcacg atgcagttcg tctgcgtcgt gccgtccagg
    17881 cacaggctct tcaggttgcg gacgatccga ccgccgaacg acgggtgggt cgggtcgacg
    17941 ccggagtcga tcacggcgac ggacacgccc tcgccggtca gcccgaggct gttgcgggcg
    18001 tcgaggccgc gggtcgcggt gtgcgaggtc gatcccagga acttgatcgg cttctggatc
    18061 tcgacgcgcg tgacgccgga tttcgccctg gcggaggaga tccgcgcggc gtcacccctc
    18121 gcggcgacca cgccgatctt gcggaagctc gtgagcttct gcaggccggc cgcctcgacc
    18181 gcctgttcgg cggcggcgat gtcggtgccg tggacgtaga ccgtggaggt cggtgcagcc
    18241 gtcgcgacag gggaagcgac ggccaccagc agtacggcga gcgatgcagc gcgtttgtac
    18301 atggaccctc cgtgaacatt ggcaggcaat ccttctaacg agtgatccac ataacggtga
    18361 cggccatcac gcaatgtctc gaccgagtgc ggtgggacga ccccggagcg ctaccgtgtc
    18421 cccccgtgcg gaaaggtggg gactcgtgcg gctgatccgt ctgggcgctg aaccctcggc
    18481 cattggggcg gacgtccgtg ccgccctcac ggcgtggggt gcgggcaccg gagtcctggg
    18541 tggtgtggcg ctgctcggcg tccagccccc cgactgcccc gtgccgctcg acgcgatcgt
    18601 cgtgctgccc aagggcgttc tcgtgatcgt cggcgtcgac ctgcccgacc ccggcgtgaa
    18661 gctcgaggcc ccgctcggcg gccagtggac gatcgacggc tggccgctcg tctcccagga
    18721 cggctcgccc aaccccgcga ccgaggccgt ggccgcggcg acggcggtgg cgcagcggat
    18781 ccaggcgatg cgcgcggaac cgctcccggt cagcacggtc gtggcggtcg gcccgttcgt
    18841 cagccaggtc gtgcagccga cgaacgacct caaccgcggc gtgcgggtgc tgcaccccaa
    18901 accgtccact ttgctcagtg cggcccgcga gctcgcgacg tcgacggtgc cgtgcacggc
    18961 cgaccacgcc atgaagctcc tcgcgatcct gcagacgacc ggcacgccac cggagtcgcg
    19021 aacgctgctg tccgagggct tcagcgaggt gtccgacctc gcggccgaga ccacgatgct
    19081 gatcccccag gcccacctgc ggcaggccat cgggcgcaaa cgcttgccag gcaagctgac
    19141 ctggccgtac ctcgcggcgg gcgcactgct cgccctggtg ctcgtggtgt ggctggtggc
    19201 cgcgctgccc ggcgacgaca agccggccga cgcgacgccc gcgccgtcgt ccgcgcagcc
    19261 gacgacggtg gtcgtggacg gcacggcgtt cgtgccgaag gagatgaaga aggaccagga
    19321 ctgcaagacg caggcgttcg gtgacgtcaa ggcgtggctg acggcgaacg actgcggcgt
    19381 gctgctgcgc gccacctacg agacgacggt gcagggcaag caggcgaccg tgctggtggc
    19441 ggacatggac gtgtacgacg cgccgagcgc gaaggcgttg cactcggtcg tcgtgctgcc
    19501 gggatcgggc ggtgtgcacg gtctcgacgg caagccgctg gagaacgcgg cgttcgccaa
    19561 caacgtcaag ggaagccacg tcacgctggc gttcgcggtg tgggagggcg gtgcgggcga
    19621 cccgtcgctc gacccgatcg ccaagcaggc gttgcggctc cccgtcagcc ggtagaggct
    19681 tgagggcatg gtcggacaac ttcgctctgt cgtgctcgac tgcccgaaca cctccgagct
    19741 cgcctcgttc tacgagcagc tgctcggggc cgaacgcctg gccggcggga ccgaggactg
    19801 ggaggtgatc gtcgcgaacg gcacgcgcgt cgcgttccag ctcgcccccg agtacgagcc
    19861 gcccacgttc cccgacccgc gcggctcgca gcagttccac ctcgacgtgc tggtggagga
    19921 catcgaagag gccgaaccga aggtgctggc gctcggggcc aagctgctgc agcgcgacaa
    19981 cgacgacacg ttccgggtct acgcggaccc ggtgggacac acgttctgcc tcgtgtggct
    20041 ctcctgatcc atacgatgcg ggcatgagcc agccgatccc gttcgccgac accaacttca
    20101 agctcgccgt cgtccaggag ctgatgtaca accagaacct gctgccgagg ttcgacctgc
    20161 gcgaacacgc cgccgcgcag ggcttcacct acgacgaggg gagcttcggg gcggtacccg
    20221 aggcgctggc ctacttcgag gcactcgagg tccccgccga gctcgccggg aagatcaccg
    20281 agatctacat ggacggcggc aacgagatct acctcgagat cgcgccgggc tgggacggcg
    20341 aggacggcct gttcgacgtc gacgagttcg ccgacgtgcg gcacttcccc aacctgaagt
    20401 ccatgacgct gctctacacg ggcaaccagg aggcgctgga ggcgctgcgc gcccgcggga
    20461 tcgaggcgga ctggctctga ggcaccccct ctgcctcgtg tggctttctt gatccaggcc
    20521 cggccctgcg ccgcgggtct cgttcgatga aagtcgcggc tgaggtggtt tctggtggtg
    20581 cgggcggctg acctgcatac cggtgttgta ttcgggtcgg ccgcccgtgc cgccagggac
    20641 cgcctccgcc ccggctttcg cggacacgga cccgcggcgc agggcctact gtggcggcca
    20701 tggacttcga cgtcatcgtc atcggtggtg gacccgtagg tgagaacgtg gcctggcgga
    20761 cggccgcggg aggcctgtcc accgccatga tcgagaagga actggtcggc ggcgagtgct
    20821 cgtactgggc ctgcatgccc tccaaggcgt tgctgcgctc cgggcacgcg ctcgccgccg
    20881 cccagcgggt caagggcgtg gtcggcgggt cgctcgatcc ggccgcggtg ctggagcggc
    20941 gcaccggctt cacctccaac tgggacgaca ccggtcaggt caagtgggcc gagtccgaga
    21001 acatccacgt cctgcgcggc gacggtgagg tcaccggcga gcgcgaggtc accgtgcgcg
    21061 gggcggacgg cgagacggtg taccgcgcgc gccaggccgt cgtggtgtgc accggcagcg
    21121 tgccgaagat gccgccgctg gacggcatcg acgacactcc cgtgtggact tcgcgcgacg
    21181 ccacgtcggc ccgcgaggtg ccggactcgc tggtcgtgct cggcggtggt gtcgtcggcg
    21241 tcgagatggc gcaggcgtgg gcgcggctgg ggtcgcaggt caagatcgtc gtgtccggcg
    21301 accggccgct gccgaagatg gaggacttcg tcggcccgct ggtcgtcgag ggcctggagg
    21361 cggacggcgt cgaggtgttg ctcaacgggc gtgcggcggc gatcaagccg ggtgagctga
    21421 cgttgcagga cggccggacg gtgcagggct cgcacatcct cgtcgcgacg ggccgggtgc
    21481 ccgccaccaa ggacggcaag ccgctgacca tcgacgactc cgggctcgtg tccggtgtgg
    21541 acggccggtg gctgtacgcg gccggcgacg tcaccgggcg cgcgttgctg acgcaccagg
    21601 gcaagtacca ggggcgcgcg gtcggcacgg cgatcctgga gcgctcccgc gggttcgagc
    21661 cgaaggagcg gtcggcgggg caggcgtggg ccgaccacgt ggcggtgccg caggtcgtgt
    21721 tcaccgaccc cgaggtggcg ttcgtcggcc acaccgccga gcaggcgcgg gccgccgggc
    21781 gcgacgtcaa ggtcgtcgac ctcgacatcg cggtcgccgg gtcgtcgctg cacgccgacg
    21841 gctacaaggg caagacccgc atggtcgtgg acgagcggac gcggacgctg gtcggtgtca
    21901 cgttcgtcgg ccaggacgtg gccgagctgc tgcactcggc caccgtcgcg atcgtcggcg
    21961 aggtcaccgt cgaccggttg tggcacgcgg tgccctcgta cccgacgatc agcgaggtct
    22021 ggctgcggct gctcgagtcc tacggcctct gaggctccag cacggagccg agcatgccgg
    22081 tgagcagctc gtccgccgtg ccgaccacgt gcgcgcgatc gtcctcgtcg acccgttcgg
    22141 cgagcttgaa cagcgcgtcc gcggtctgca cggcgatccg gaacgtcagc acgaccgggg
    22201 cgtcgccgtg ggcgccgaac cggccgacga acatctcggc gagccgttcg gccatcaact
    22261 cgtactggtc gacgctggag tccagacggt ggctgtccag catgtcgctg aaccggacgc
    22321 gcccgaagcc gggcacgtcc gccagcatgc gcgtgtagat cgcgacgacc tgccgggtgg
    22381 cctcgcgcca cgtgtccgcg atcaggtcct cggtgaacag ctcctcgact tcgcggaggt
    22441 agttctccat acctcgaagt gccagagcgt gcacgacaga tcgtttgtcc gggaagtact
    22501 gatagaaaga accaatgggc actccggcca cgtcgacgat gcgagccgtc gtgatgtcgt
    22561 cgtag
//
